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Aliases for MATN2 Gene

Aliases for MATN2 Gene

  • Matrilin 2 2 3 5

External Ids for MATN2 Gene

Previous GeneCards Identifiers for MATN2 Gene

  • GC08P098955
  • GC08P098550
  • GC08P098837
  • GC08P098950
  • GC08P098881
  • GC08P094085

Summaries for MATN2 Gene

Entrez Gene Summary for MATN2 Gene

  • This gene encodes a member of the von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains five von Willebrand factor A domains. The specific function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MATN2 Gene

MATN2 (Matrilin 2) is a Protein Coding gene. Diseases associated with MATN2 include Pilocytic Astrocytoma. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is MATN1.

UniProtKB/Swiss-Prot for MATN2 Gene

  • Involved in matrix assembly.

Gene Wiki entry for MATN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MATN2 Gene

Genomics for MATN2 Gene

Regulatory Elements for MATN2 Gene

Enhancers for MATN2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MATN2 on UCSC Golden Path with GeneCards custom track

Promoters for MATN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MATN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MATN2 Gene

97,868,840 bp from pter
98,036,720 bp from pter
167,881 bases
Plus strand

Genomic View for MATN2 Gene

Genes around MATN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MATN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MATN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MATN2 Gene

Proteins for MATN2 Gene

  • Protein details for MATN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K106
    • E7EW74
    • E9PD48
    • E9PGL2
    • Q6UWA5
    • Q7Z5X1
    • Q8NDE6
    • Q96FT5
    • Q9NSZ1

    Protein attributes for MATN2 Gene

    956 amino acids
    Molecular mass:
    106837 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAD38787.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MATN2 Gene


neXtProt entry for MATN2 Gene

Proteomics data for MATN2 Gene at MOPED

Post-translational modifications for MATN2 Gene

  • Glycosylation at Thr 40, Asn 221, Thr 902, and Ser 905
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for MATN2 Gene

Domains & Families for MATN2 Gene

Suggested Antigen Peptide Sequences for MATN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 10 EGF-like domains.
  • Contains 10 EGF-like domains.
  • Contains 2 VWFA domains.
genes like me logo Genes that share domains with MATN2: view

No data available for Gene Families for MATN2 Gene

Function for MATN2 Gene

Molecular function for MATN2 Gene

UniProtKB/Swiss-Prot Function:
Involved in matrix assembly.

Gene Ontology (GO) - Molecular Function for MATN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MATN2: view
genes like me logo Genes that share phenotypes with MATN2: view

Animal Models for MATN2 Gene

MGI Knock Outs for MATN2:

Animal Model Products

  • Taconic Biosciences Mouse Models for MATN2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MATN2 Gene

Localization for MATN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MATN2 Gene


Subcellular locations from

Jensen Localization Image for MATN2 Gene COMPARTMENTS Subcellular localization image for MATN2 gene
Compartment Confidence
extracellular 5
plasma membrane 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for MATN2 Gene

Pathways & Interactions for MATN2 Gene

SuperPathways for MATN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MATN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007411 axon guidance IEA --
GO:0008150 biological_process ND --
GO:0031104 dendrite regeneration IEA --
GO:0048678 response to axon injury IEA --
genes like me logo Genes that share ontologies with MATN2: view

No data available for Pathways by source and SIGNOR curated interactions for MATN2 Gene

Drugs & Compounds for MATN2 Gene

No Compound Related Data Available

Transcripts for MATN2 Gene

Unigene Clusters for MATN2 Gene

Matrilin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MATN2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d ^ 16 ^
SP1: -
SP3: - -
SP8: - -

ExUns: 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
SP2: -

Relevant External Links for MATN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MATN2 Gene

mRNA expression in normal human tissues for MATN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MATN2 Gene

This gene is overexpressed in Cervix - Ectocervix (x4.9).

Protein differential expression in normal tissues from HIPED for MATN2 Gene

This gene is overexpressed in Amniocyte (27.3) and Gallbladder (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MATN2 Gene

SOURCE GeneReport for Unigene cluster for MATN2 Gene Hs.189445

genes like me logo Genes that share expression patterns with MATN2: view

Protein tissue co-expression partners for MATN2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MATN2 Gene

Orthologs for MATN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MATN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MATN2 35
  • 89.61 (n)
  • 90.59 (a)
MATN2 36
  • 90 (a)
(Canis familiaris)
Mammalia MATN2 35
  • 89.12 (n)
  • 89.02 (a)
MATN2 36
  • 89 (a)
(Mus musculus)
Mammalia Matn2 35
  • 86.18 (n)
  • 87.61 (a)
Matn2 16
Matn2 36
  • 87 (a)
(Pan troglodytes)
Mammalia MATN2 35
  • 99.27 (n)
  • 99.27 (a)
MATN2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Matn2 35
  • 87.87 (n)
  • 89.31 (a)
(Monodelphis domestica)
Mammalia MATN2 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia MATN2 36
  • 65 (a)
(Gallus gallus)
Aves MATN2 36
  • 68 (a)
(Anolis carolinensis)
Reptilia MATN2 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia matn2 35
  • 66.59 (n)
  • 64.86 (a)
MGC76198 35
African clawed frog
(Xenopus laevis)
Amphibia matn2-prov 35
(Danio rerio)
Actinopterygii matn4 35
  • 57.22 (n)
  • 48.99 (a)
(Caenorhabditis elegans)
Secernentea mup-4 37
  • 27 (a)
mup-4 36
  • 12 (a)
Species with no ortholog for MATN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MATN2 Gene

Gene Tree for MATN2 (if available)
Gene Tree for MATN2 (if available)

Paralogs for MATN2 Gene

genes like me logo Genes that share paralogs with MATN2: view

Variants for MATN2 Gene

Sequence variations from dbSNP and Humsavar for MATN2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1869609 - 97,978,993(-) TTTTT(C/T)ATCTG reference, missense
rs35804177 - 97,888,141(+) CCTCG(C/G)ACAGA reference, missense
rs2290472 - 97,931,370(+) GGACA(C/T)GGGCA reference, missense
rs35120814 - 98,018,092(+) GGCTC(A/G)CTGAG reference, missense
rs2255317 - 98,032,300(-) GGACC(A/G/T)TTTTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MATN2 Gene

Variant ID Type Subtype PubMed ID
nsv891214 CNV Gain 21882294
nsv891215 CNV Gain 21882294
nsv528695 CNV Gain 19592680
esv26559 CNV Gain 19812545

Variation tolerance for MATN2 Gene

Residual Variation Intolerance Score: 98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.18; 92.39% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MATN2 Gene

Disorders for MATN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MATN2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pilocytic astrocytoma
  • grade i astrocytic tumor
- elite association - COSMIC cancer census association via MalaCards
Search MATN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MATN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MATN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MATN2 Gene

Publications for MATN2 Gene

  1. Primary structure and expression of matrilin-2, the closest relative of cartilage matrix protein within the von Willebrand factor type A- like module superfamily. (PMID: 9083061) Deak F. … Kiss I. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. Comparative analysis of the mouse and human genes (Matn2 and MATN2) for matrilin-2, a filament-forming protein widely distributed in extracellular matrices. (PMID: 11852232) MA!tAcs L. … Kiss I. (Matrix Biol. 2002) 2 3 23
  3. DeltaNp63/BMP-7-dependent expression of matrilin-2 is involved in keratinocyte migration in response to wounding. (PMID: 18328806) Ichikawa T. … Nakagawara A. (Biochem. Biophys. Res. Commun. 2008) 3 23
  4. Expression of matrilin-2 in liver cirrhosis and hepatocellular carcinoma. (PMID: 18386166) SzabA^ E. … Kiss A. (Pathol. Oncol. Res. 2008) 3 23
  5. Matrilin-2 expression distinguishes clinically relevant subsets of pilocytic astrocytoma. (PMID: 16401863) Sharma M.K. … Gutmann D.H. (Neurology 2006) 3 23

Products for MATN2 Gene

Sources for MATN2 Gene