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Aliases for MATN2 Gene

Aliases for MATN2 Gene

  • Matrilin 2 2 3
  • Matrilin-2 3

External Ids for MATN2 Gene

Summaries for MATN2 Gene

Entrez Gene Summary for MATN2 Gene

  • This gene encodes a member of the von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains five von Willebrand factor A domains. The specific function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MATN2 Gene

MATN2 (Matrilin 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is MATN1.

UniProtKB/Swiss-Prot for MATN2 Gene

  • Involved in matrix assembly.

Gene Wiki entry for MATN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MATN2 Gene

Genomics for MATN2 Gene

Genomic Location for MATN2 Gene

Start:
97,868,840 bp from pter
End:
98,036,720 bp from pter
Size:
167,881 bases
Orientation:
Plus strand

Genomic View for MATN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MATN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MATN2 Gene

Regulatory Elements for MATN2 Gene

Proteins for MATN2 Gene

  • Protein details for MATN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00339-MATN2_HUMAN
    Recommended name:
    Matrilin-2
    Protein Accession:
    O00339
    Secondary Accessions:
    • A8K106
    • E7EW74
    • E9PD48
    • E9PGL2
    • Q6UWA5
    • Q7Z5X1
    • Q8NDE6
    • Q96FT5
    • Q9NSZ1

    Protein attributes for MATN2 Gene

    Size:
    956 amino acids
    Molecular mass:
    106837 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD38787.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MATN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MATN2 Gene

Proteomics data for MATN2 Gene at MOPED

Post-translational modifications for MATN2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr40, Asn221, Ser901, Thr902, and Ser905

No data available for DME Specific Peptides for MATN2 Gene

Domains for MATN2 Gene

UniProtKB/Swiss-Prot:

MATN2_HUMAN
Domain:
  • Contains 10 EGF-like domains.:
    • O00339
  • Contains 2 VWFA domains.:
    • O00339
genes like me logo Genes that share domains with MATN2: view

No data available for Gene Families for MATN2 Gene

Function for MATN2 Gene

Molecular function for MATN2 Gene

UniProtKB/Swiss-Prot Function: Involved in matrix assembly.

Gene Ontology (GO) - Molecular Function for MATN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 21078624
genes like me logo Genes that share ontologies with MATN2: view

Phenotypes for MATN2 Gene

genes like me logo Genes that share phenotypes with MATN2: view

Animal Models for MATN2 Gene

MGI Knock Outs for MATN2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for MATN2 Gene

Localization for MATN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MATN2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MATN2 Gene COMPARTMENTS Subcellular localization image for MATN2 gene
Compartment Confidence
extracellular 5
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MATN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix NAS 11124542
GO:0005604 basement membrane IEA --
GO:0031012 colocalizes_with extracellular matrix ISS 22261194
genes like me logo Genes that share ontologies with MATN2: view

Pathways for MATN2 Gene

SuperPathways for MATN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MATN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0007411 axon guidance IEA --
GO:0008150 biological_process ND --
GO:0008347 glial cell migration IEA --
GO:0031104 dendrite regeneration IEA --
genes like me logo Genes that share ontologies with MATN2: view

No data available for Pathways by source for MATN2 Gene

Transcripts for MATN2 Gene

Unigene Clusters for MATN2 Gene

Matrilin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MATN2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d ^ 16 ^
SP1: -
SP2:
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:

ExUns: 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for MATN2 Gene

GeneLoc Exon Structure for
MATN2
ECgene alternative splicing isoforms for
MATN2

Expression for MATN2 Gene

mRNA expression in normal human tissues for MATN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MATN2 Gene

This gene is overexpressed in Cervix - Ectocervix (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MATN2 Gene

SOURCE GeneReport for Unigene cluster for MATN2 Gene Hs.189445

genes like me logo Genes that share expressions with MATN2: view

Orthologs for MATN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MATN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MATN2 36
  • 99.27 (n)
  • 99.27 (a)
MATN2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MATN2 36
  • 89.61 (n)
  • 90.59 (a)
MATN2 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MATN2 36
  • 89.12 (n)
  • 89.02 (a)
MATN2 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Matn2 36
  • 86.18 (n)
  • 87.61 (a)
Matn2 16
Matn2 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MATN2 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MATN2 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Matn2 36
  • 87.87 (n)
  • 89.31 (a)
chicken
(Gallus gallus)
Aves MATN2 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MATN2 37
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia matn2-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia matn2 36
  • 66.59 (n)
  • 64.86 (a)
MGC76198 36
zebrafish
(Danio rerio)
Actinopterygii matn4 36
  • 57.22 (n)
  • 48.99 (a)
worm
(Caenorhabditis elegans)
Secernentea mup-4 37
  • 12 (a)
OneToMany
mup-4 38
  • 27 (a)
Species with no ortholog for MATN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MATN2 Gene

ENSEMBL:
Gene Tree for MATN2 (if available)
TreeFam:
Gene Tree for MATN2 (if available)

Paralogs for MATN2 Gene

Paralogs for MATN2 Gene

genes like me logo Genes that share paralogs with MATN2: view

Variants for MATN2 Gene

Sequence variations from dbSNP and Humsavar for MATN2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2615 -- 98,036,101(-) GTCCA(A/G)TACAA utr-variant-3-prime
rs748324 -- 98,011,851(+) ACTTA(C/T)GTGAC intron-variant
rs753799 -- 97,918,484(-) ATGTC(A/G)CCCCA intron-variant
rs753800 -- 97,918,474(-) ACAAA(C/T)ACTTA intron-variant
rs764568 -- 97,931,756(+) GTAGT(G/T)CAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MATN2 Gene

Variant ID Type Subtype PubMed ID
nsv891214 CNV Gain 21882294
nsv891215 CNV Gain 21882294
nsv528695 CNV Gain 19592680
esv26559 CNV Gain 19812545

Relevant External Links for MATN2 Gene

HapMap Linkage Disequilibrium report
MATN2

Disorders for MATN2 Gene

Relevant External Links for MATN2

Genetic Association Database (GAD)
MATN2
Human Genome Epidemiology (HuGE) Navigator
MATN2
genes like me logo Genes that share disorders with MATN2: view

No data available for UniProtKB/Swiss-Prot for MATN2 Gene

Publications for MATN2 Gene

  1. Primary structure and expression of matrilin-2, the closest relative of cartilage matrix protein within the von Willebrand factor type A- like module superfamily. (PMID: 9083061) Deak F. … Kiss I. (J. Biol. Chem. 1997) 2 3 4 23
  2. Primary structure of human matrilin-2, chromosome location of the MATN2 gene and conservation of an AT-AC intron in matrilin genes. (PMID: 11124542) Muratoglu S. … Deak F. (Cytogenet. Cell Genet. 2000) 3 4 23
  3. Comparative analysis of the mouse and human genes (Matn2 and MATN2) for matrilin-2, a filament-forming protein widely distributed in extracellular matrices. (PMID: 11852232) MA!tAcs L. … Kiss I. (Matrix Biol. 2002) 2 3 23
  4. Characterization of the matrilin coiled-coil domains reveals seven novel isoforms. (PMID: 11896063) Frank S. … Kammerer R.A. (J. Biol. Chem. 2002) 3 23
  5. Expression of matrilin-2 in human skin. (PMID: 12164922) Piecha D. … Paulsson M. (J. Invest. Dermatol. 2002) 3 23

Products for MATN2 Gene

Sources for MATN2 Gene

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