MATN1 Gene

Aliases
for MATN1 gene

Previous GC identifers: GC01M030980 GC01M030170 GC01M030612 GC01M030688 GC01M030855 GC01M029288

Summaries
for MATN1 gene

Genomic Views
for MATN1 gene

RefSeq DNA sequence:

NC_000001.10  NC_018912.1  NT_032977.9  

SwitchGear Promoter luciferase reporter plasmids (see all 2): MATN1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MATN1

MATN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M031184:  view genomic region     (about GC identifiers)

Proteins
for MATN1 gene

Explore the universe of human proteins at neXtProt for MATN1: NX_P21941

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: MATN1 OriGene Custom Protein Services for MATN1
	GenScript Custom Purified and Recombinant Proteins Services for MATN1
	Novus Biologicals MATN1 Proteins Novus Biologicals MATN1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MATN1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for MATN1 (Matrilin-1)
	OriGene Antibodies (see all 2): MATN1 OriGene Custom Antibody Services for MATN1
	GenScript Custom Superior Antibodies Services for MATN1
	Novus Biologicals MATN1 Antibodies
	Search for Antibodies for MATN1 at Abcam
	Uscn Antibodies for MATN1
	ThermoFisher Antibodies for MATN1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MATN1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MATN1

Protein Domains /
Families
for MATN1 gene

ProtoNet protein and cluster: P21941

Function
for MATN1 gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MATN1
		8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate MATN1 (see all 36):
		hsa-miR-548j hsa-miR-100* hsa-miR-136 hsa-miR-513a-5p hsa-miR-342-3p hsa-miR-29b-1* hsa-miR-3613-3p hsa-miR-548d-5p
		SwitchGear 3'UTR luciferase reporter plasmid: MATN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MATN1 (see all 7) OriGene shRNA RFP: MATN1 OriGene siRNA: MATN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MATN1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for MATN1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MATN1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MATN1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MATN1 (NM_002379)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MATN1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MATN1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MATN1
		Search LifeMap BioReagents cell lines for MATN1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MATN1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Matn1)

Pathways & Interactions
for MATN1 gene

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for MATN1 gene

Transcripts
for MATN1 gene

Expression
for MATN1 gene

MATN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAAGAGCA

10/26 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 26)
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BoneCaudal Endochondral BonesPrehypertrophic Chondrocytes			Bone, Cartilage
	BoneEndochondral Facial BonesPrehypertrophic Chondrocytes			Bone, Cartilage
	BoneRostral Endochondral Facial BonesPrehypertrophic Chondrocytes			Bone, Cartilage
	CartilageRostral SynchondrosesChondrocytes			Bone, Cartilage
	CartilageSynchondrosesChondrocytes			Bone, Cartilage
	Head MesenchymeBranchial Arch 2Chondrocytes			Bone, Cartilage
	LimbStylopod Synovial JointInterzone Cells			Cartilage
	LimbZeugopodMesenchymal Condensate Cells			Bone, Cartilage
	BoneCaudal Endochondral Bones			Bone
	BoneEndochondral Facial Bones			Bone
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MATN1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MATN1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MATN1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MATN1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MATN1

Orthologs
for MATN1 gene

Paralogs
for MATN1 gene

Paralogs for MATN1 gene

VWA1²  MATN4²  COL14A1²  COL9A1²  MATN3²  MATN2²  VIT²  COL12A1²  

COL9A3²  COCH²  COL9A2²  COL20A1²  VWA2²  COL21A1²  

5 SIMAP similar genes for MATN1 using alignment to 2 protein entries:     MATN1_HUMAN (see all proteins):

MATN3    MATN2    COL21A1    MATN4    COL6A5

MATN1 for paralogs           About GeneDecksing

Genomic Variants
for MATN1 gene

10/291 NCBI SNPs in MATN1 are shown (see all 291)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs583295811,2		--	29287931(+)	TGCGAC/TGCCCC	1	--	ds5001		0	--	--	--	--
rs572335711,2	F,	--	29287972(+)	ACATAC/ACTTGA	1	--	ds5001		1		WA	118
rs75557151,2	C,F,A,H,	--	29288073(+)	AGTCCC/ATGAGC	1	--	ds5001		20		NS EA NA WA	2346
rs345585951,2	C,	--	29288810(+)	ATGGCG/ATCCGC	1	--	ut31		5		WA NA EA	362
rs792674521,2	F,	--	29289107(+)	AAGTCG/ACGCTT	1	--	ut31		1		WA	118
rs591098681,2	C,	--	29289497(+)	ATCTGC/TGTTGG	1	--	ut31		1		WA	2
rs800085231,2	F,	--	29289689(+)	CCCTGG/ATACGA	1	--	ut31		1		WA	118
rs740633761,2	C	--	29289820(+)	CCCCCC/ACCGCC	1	--	ut31		1		WA	2
rs1125738411,2	F	--	29290226(+)	CTGGTC/ACCCAA	1	--	ut31		2		CSA	4
rs1121131841,2	F	--	29290478(+)	CAGGCG/ACACGT	1	--	ut31		2		CSA	4

HapMap Linkage Disequilibrium report for MATN1 (31184124 - 31196434 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for MATN1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MATN1

DNA2.0 Custom Variant and Variant Library Synthesis for MATN1

Disorders / Diseases
for MATN1 gene

17 diseases for MATN1

9 Novoseek disease relationships for MATN1 gene    About this table

Publications
for MATN1 gene

PubMed articles for MATN1 gene, integrated from 9 sources (see all 117): (articles sorted by number of sources associating them with MATN1)

Utopia: connect your pdf to the dynamic world of online information

1. Structure and chromosomal location of the human gene encoding cartilage matrix protein. (PubMed id 2246248)^{1, 2, 3, 9} Jenkins R.N.... Duby A.D. (1990)
2. Association analysis of genotypic frequencies of matrilin-1 gene in patients with osteoarthritis. (PubMed id 12175111)^{1, 4, 9} Strusberg I....Barral J.M. (2002)
3. Primary structure and expression of matrilin-2, the closest relative of cartilage matrix protein within the von Willebrand factor type A- like module superfamily. (PubMed id 9083061)^{1, 3, 9} Deak F.... Kiss I. (1997)
4. Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias. (PubMed id 15075323)^{1, 2, 9} Mann H.H....Wagener R. (2004)
5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
6. [Decreased circulating matrilin-1 levels in adolescen t idiopathic scoliosis.] (PubMed id 20137399)^{1, 9} Wang B....Liu W.J. (2009)
7. Evidence of a linkage between matrilin-1 gene (MATN1) and idiopathic scoliosis. (PubMed id 17176459)^{1, 9} Montanaro L....Arciola C.R. (2006)
8. Enhancement of cell adhesion and spreading by a cartilage-specific noncollagenous protein, cartilage matrix protein (CMP/Matrilin-1), via integrin alpha1beta1. (PubMed id 10196235)^{1, 9} Makihira S....Kato Y. (1999)
9. Promoter polymorphism of matrilin-1 gene predisposes to adolescent idiopathic scoliosis in a Chinese population. (PubMed id 18985072)^{1, 9} Chen Z....Qiu Y. (2008)
10. Characterization of the matrilin coiled-coil domains reveals seven novel isoforms. (PubMed id 11896063)^{1, 9} Frank S....Kammerer R.A. (2002)

External Searches for MATN1 gene

Genome Databases showing MATN1 gene

Other Databases showing MATN1 gene

Specialized Databases showing MATN1 gene

Products
for MATN1 gene