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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MATK Gene

protein-coding   GIFtS: 65
GCID: GC19M003777

Megakaryocyte-Associated Tyrosine Kinase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Megakaryocyte-Associated Tyrosine Kinase1 2     Tyrosine Kinase MATK1 2
Hematopoietic Consensus Tyrosine-Lacking Kinase1 2 3     Tyrosylprotein Kinase1 2
Protein Kinase HYL1 2 3     CHK2 3
Tyrosine-Protein Kinase CTK1 2 3     CSK Homologous Kinase2 3
CTK2 3 5     EC 2.7.10.23 8
HYL2 3 5     HHYLTK2
Csk-Homologous Kinase1 2     HYLTK2
Csk-Type Protein Tyrosine Kinase1 2     Lsk2
Hydroxyaryl-Protein Kinase1 2     Megakaryocyte-Associated Tyrosine-Protein Kinase2
HYL Tyrosine Kinase1 2     EC 2.7.108
Leukocyte Carboxyl-Terminal Src Kinase Related1 2     

External Ids:    HGNC: 69061   Entrez Gene: 41452   Ensembl: ENSG000000072647   OMIM: 6000385   UniProtKB: P426793   

Export aliases for MATK gene to outside databases

Previous GC identifers: GC19M003870 GC19M003717 GC19M003728 GC19M003542


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MATK Gene:
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural
features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of
myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation
site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is
able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell
proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively
spliced transcript variants that encode different isoforms have been described for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for MATK Gene: 
MATK (megakaryocyte-associated tyrosine kinase) is a protein-coding gene. Diseases associated with MATK include preretinal fibrosis, and spondylolisthesis, and among its related super-pathways are Kit Receptor Signaling Pathway and Downstream signaling of activated FGFR. GO annotations related to this gene include non-membrane spanning protein tyrosine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is DSTYK.

UniProtKB/Swiss-Prot: MATK_HUMAN, P42679
Function: Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine
kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory
tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of
T-cell proliferation

Gene Wiki entry for MATK (Megakaryocyte-associated tyrosine kinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MATK gene promoter:
         TBP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MATK promoter sequence
   Search SABiosciences Chromatin IP Primers for MATK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MATK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

MATK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MATK gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M003777:  view genomic region     (about GC identifiers)

Start:
3,777,967 bp from pter      End:
3,802,127 bp from pter
Size:
24,161 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MATK_HUMAN, P42679 (See protein sequence)
Recommended Name: Megakaryocyte-associated tyrosine-protein kinase  
Size: 507 amino acids; 56469 Da
Subunit: Interacts with KIT
Subcellular location: Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and
translocates to the cytoskeleton upon thrombin stimulation
3 PDB 3D structures from and Proteopedia for MATK:
1JWO (3D)        1X6G (3D)        3US4 (3D)    
Secondary accessions: B3KNZ9 Q9NST8
Alternative splicing: 3 isoforms:  P42679-1   P42679-2   P42679-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MATK: NX_P42679

Explore proteomics data for MATK at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P42679

  • 4/5 DME Specific Peptides for MATK (P42679) (see all 5)
     KWTAPEA  RDLAARN  TSKSDVW  KSDVWSFG 

    MATK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MATK Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_002369.2  NP_647611.1  NP_647612.1  

    ENSEMBL proteins: 
     ENSP00000378481   ENSP00000308734   ENSP00000468030   ENSP00000378485   ENSP00000468576  
     ENSP00000465761   ENSP00000468465   ENSP00000467006   ENSP00000467992   ENSP00000465556  
     ENSP00000467472  
    Reactome Protein details: P42679
    Human Recombinant Protein Products for MATK: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for MATK
    OriGene Protein Over-expression Lysate for MATK
    OriGene MassSpec for MATK 
    OriGene Custom Protein Services for MATK
    GenScript Custom Purified and Recombinant Proteins Services for MATK
    Novus Biologicals MATK Proteins
    Novus Biologicals MATK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MATK 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0016020membrane IEA--

    MATK for ontologies           About GeneDecksing



    MATK Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals MATK Antibodies
    Abcam antibodies for MATK
    Cloud-Clone Corp. Antibodies for MATK 
    ThermoFisher Antibodies for MATK
    LSBio Antibodies in human, mouse, rat for MATK 

    Assay Products for MATK: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MATK
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MATK 
    Cloud-Clone Corp. CLIAs for MATK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: megakaryocyte-associated tyrosine kinase 
    Csk family

    5/8 InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR001452 SH3_domain
     IPR000719 Prot_kinase_cat_dom
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P42679

    ProtoNet protein and cluster: P42679

    4 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: MATK_HUMAN, P42679
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    MATK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MATK_HUMAN, P42679
    Function: Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine
    kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory
    tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of
    T-cell proliferation
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for MATK:
    megakaryocyte-associated tyrosine kinase

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS7530249
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI12122014
    GO:0005524ATP binding IEA--
         
    MATK for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MATK:
     Decreased Salmonella enterica   Decreased substrate adherent c 

         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Matk):
     hematopoietic system  normal 

    MATK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MATK: Matktm1Suda Matktm1Hua Matktm1Sor

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MATK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MATK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MATK 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MATK 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MATK
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MATK
    SwitchGear 3'UTR luciferase reporter plasmidMATK 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MATK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MATK

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of MATK

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MATK (see all 18)
    OriGene ORF clones in mouse, rat for MATK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MATK (NM_139354)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MATK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MATK
    Sirion Biotech Customized lentivirus for stable overexpression of MATK 
                         Customized lentivirus expression plasmids for stable overexpression of MATK 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MATK
    Search LifeMap BioReagents cell lines for MATK
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MATK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MATK About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling events mediated by Stem cell factor receptor (c-Kit)
    Signaling events mediated by Stem cell factor receptor (c-Kit)0.37
    Kit Receptor Signaling Pathway0.37
    2Signaling by FGFR
    Signaling by ERBB20.90
    3Signaling by GPCR
    Signal Transduction0.55
    4Development HGF signaling pathway
    Neurotrophin signaling pathway0.36
    5Neurotrophic factor-mediated Trk receptor signaling
    Neurotrophic factor-mediated Trk receptor signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for MATK
        Kit Receptor Signaling Pathway
    IL-3 Signaling Pathway
    Signaling events mediated by Stem cell factor receptor (c-Kit)
    Neurotrophic factor-mediated Trk receptor signaling

    2        Reactome Pathways for MATK
        Signaling by ERBB2
    Signal Transduction


    1         Kegg Pathway  (Kegg details for MATK):
        Neurotrophin signaling pathway


    MATK for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MATK

    5/14 Interacting proteins for MATK (P426791, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262, 3MINT-8038609 MINT-74582 I2D: score=4 
    PTK2BQ142892, 3MINT-8037577 MINT-8037562 I2D: score=3 
    EWSR1Q018443I2D: score=3 
    PXNP490233I2D: score=3 
    SRCP129313I2D: score=3 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS7530249
    GO:0007498mesoderm development TAS8288563
    GO:0008283cell proliferation TAS8288563
    GO:0008284positive regulation of cell proliferation TAS8999872

    MATK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MATK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MATK

    3 Novoseek inferred chemical compound relationships for MATK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 63.5 83 16707123 (5), 10080957 (4), 11309195 (4), 8134117 (3) (see all 25)
    phosphotyrosine 58.6 2 10080957 (1), 8995444 (1)
    atp 0 2 15805285 (1)

    Search CenterWatch for drugs/clinical trials and news about MATK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MATK gene (3 alternative transcripts): 
    NM_002378.3  NM_139354.2  NM_139355.2  

    Unigene Cluster for MATK:

    Megakaryocyte-associated tyrosine kinase
    Hs.631845  [show with all ESTs]
    Unigene Representative Sequence: BC000114
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395040(uc002lyu.3) ENST00000310132(uc002lyt.3 uc010dtq.3)
    ENST00000585778 ENST00000395045(uc002lyv.3) ENST00000590493 ENST00000588983
    ENST00000587180 ENST00000590028 ENST00000590849 ENST00000591059 ENST00000590980
    ENST00000590821 ENST00000592612 ENST00000592300
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MATK
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MATK
    SwitchGear 3'UTR luciferase reporter plasmidMATK 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MATK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MATK
    Clone
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    OriGene clones in human, mouse for MATK (see all 18)
    OriGene ORF clones in mouse, rat for MATK
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    GenScript: all cDNA clones in your preferred vector (see all 3): MATK (NM_139354)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MATK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MATK
    Sirion Biotech Customized lentivirus for stable overexpression of MATK 
                         Customized lentivirus expression plasmids for stable overexpression of MATK 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MATK
    OriGene qSTAR qPCR primer pairs in human, mouse for MATK
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MATK
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MATK

    Additional mRNA sequence: 

    AB593100.1 AK055395.1 AK225834.1 AK315646.1 AL137754.1 BC000114.1 BC003109.1 L18974.1 
    S71669.1 X77278.1 

    10 DOTS entries:

    DT.207287  DT.100751532  DT.92427625  DT.100751530  DT.92427626  DT.121463252  DT.121463261  DT.121463265 
    DT.40275271  DT.91855610 

    24/113 AceView cDNA sequences (see all 113):

    BU073359 BQ549211 BQ054024 CR614369 X77278 BU617908 BX283424 NM_139354 
    BI768288 AL137754 CR619542 BU070968 BE791829 BU077688 BC003109 BC000114 
    BM313978 AI357047 NM_139355 CR610757 BM726725 AL538511 BI769001 BM701130 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MATK (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^
    SP1:                          -     -                       -                                         -           -                                             
    SP2:                          -     -                       -                                         -           -                                             
    SP3:        -     -     -     -     -     -     -           -                                         -           -                                             
    SP4:                          -     -     -     -           -                                         -           -                                             
    SP5:                                                                                                                                            -               

    ExUns: 17 ^ 18 ^ 19a · 19b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for MATK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MATK expression in normal human tissues (normalized intensities)      MATK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCAGCTGCT
    MATK Expression
    About this image


    MATK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Cerebral Cortex
             Septum   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Fetal Liver CD36+ Cells   
             monocyte-derived macrophage   
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Liver (Hepatobiliary System)
             Fetal Liver CD36+ Cells   
     
     Umbilical Cord (Extraembryonic Tissues)
             Cord Blood Natural Killer Cells (CD56+)   

    See MATK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MATK

    SOURCE GeneReport for Unigene cluster: Hs.631845

    UniProtKB/Swiss-Prot: MATK_HUMAN, P42679
    Tissue specificity: Expressed in various myeloid cell lines, detected in brain and lung

        SABiosciences Custom PCR Arrays for MATK
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MATK
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MATK
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MATK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MATK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MATK gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Matk1 , 5 megakaryocyte-associated tyrosine kinase1, 5 83.56(n)1
    87.72(a)1
      10 (39.72 cM)5
    171791  NM_010768.11  NP_034898.11 
     812529355 
    chicken
    (Gallus gallus)
    Aves MATK6
    megakaryocyte-associated tyrosine kinase
    71(a)
    1 ↔ 1
    28(961655-965629)
    zebrafish
    (Danio rerio)
    Actinopterygii matk6
    megakaryocyte-associated tyrosine kinase
    63(a)
    1 ↔ 1
    22(4677390-4692900)
    fruit fly
    (Drosophila melanogaster)
    Insecta Csk3 protein amino acid phosphorylation
    protein tyrosine more
    48(a)   86E17   --
    worm
    (Caenorhabditis elegans)
    Secernentea T25B9.53 Src homology domain 2, protein tyrosine
    kinase more
    31(a)
    (best of 3)
      IV(10752605-10754764)   --


    ENSEMBL Gene Tree for MATK (if available)
    TreeFam Gene Tree for MATK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MATK gene
    DSTYK2  FER2  CSK2  FES2  
    18/42 SIMAP similar genes for MATK using alignment to 10 protein entries:     MATK_HUMAN (see all proteins) (see all similar genes):
    lsk    CSK    EGFR    ABL1    BTK kinase deficient isoform 6    BTK kinase deficient isoform 2
    MARK2    BTK kinase deficient isoform 4    EPHA2    tec    DKFZp564L2416    TIE1
    DKFZp686M05208    BMX    FGFR2    FES    GRB2    BRSK2

    MATK for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MATK
    PGOHUM00000234119


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/657 SNPs in MATK are shown (see all 657)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0416794
    An ovarian mucinous carcinoma sample4--see VAR_0416792 A T mis40--------
    VAR_0416814
    A colorectal adenocarcinoma sample4--see VAR_0416812 R Q mis40--------
    rs351526051,2
    C,F--3777623(+) CAGTGG/ACCAGC 3 -- ds50019Minor allele frequency- A:0.34NA WA EA 370
    rs1866203081,2
    --3777669(+) AAGATA/GGGGAG 3 -- ds50010--------
    rs1425731381,2
    C--3777706(+) AGGAGG/TCAGGG 3 -- ds50010--------
    rs1912956431,2
    --3777941(+) GGGCAC/TGGGGA 3 -- ds50010--------
    rs1821911391,2
    --3777959(+) ACACAC/GAGGCG 3 -- ds50010--------
    rs1465467631,2
    C--3778065(+) CTGCTC/GTGGGC 3 -- ut310--------
    rs1867946671,2
    --3778091(+) TGCCCA/GCCTGG 3 -- ut310--------
    rs1996108551,2
    --3778184(+) GGTCAC/GGGCTC 6 P syn10--------

    HapMap Linkage Disequilibrium report for MATK (3777967 - 3802127 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for MATK (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662849CNV Deletion23128226
    esv1011184CNV Deletion20482838
    nsv509718CNV Insertion20534489
    nsv910780CNV Loss21882294
    dgv3651n71CNV Loss21882294
    nsv910722CNV Loss21882294
    nsv910775CNV Loss21882294
    dgv3663n71CNV Loss21882294
    dgv3664n71CNV Loss21882294
    nsv470114CNV Loss18288195

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600038    OMIM disorders: --

    13 diseases for MATK:    About MalaCards
    preretinal fibrosis    spondylolisthesis    astigmatism    hyperopia
    endocarditis    breast cancer    myopia    macular degeneration
    neuroblastoma    ataxia    pancreatic cancer    colon cancer
    pancreatitis

    5 diseases from the University of Copenhagen DISEASES database for MATK:
    Astigmatism     Preretinal fibrosis     Hyperopia     Spondylolisthesis
    Myopia

    MATK for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for MATK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 22.1 23 9461599 (5), 11445575 (4), 12122014 (3), 8999872 (3) (see all 6)
    tumors 0 5 15104145 (1), 11445575 (1), 15329911 (1)
    cancer 0 4 16243715 (2), 12429987 (1)

    Tumor Gene Database (TGDB): MATK

    Export disorders for MATK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MATK gene, integrated from 9 sources (see all 73):
    (articles sorted by number of sources associating them with MATK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel tyrosine kinase from megakaryocytes. (PubMed id 8288563)1, 2, 3, 9 Bennett B.D.... Avraham H. (1994)
    2. Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product. (PubMed id 7530249)1, 2, 3, 9 Avraham S....Avraham H. (1995)
    3. Characterization of mouse non-receptor tyrosine kinase gene, HYL. (PubMed id 7936664)1, 2, 9 Hamaguchi I.... Suda T. (1994)
    4. Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase). (PubMed id 8134117)1, 2, 9 Sakano S.... Suda T. (1994)
    5. Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. (PubMed id 9038210)1, 2, 9 Price D.J....Avraham H. (1997)
    6. Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets. (PubMed id 9171348)1, 2, 9 Hirao A....Yamaguchi N. (1997)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The Csk-like proteins Lsk, Hyl, and Matk represent the same Csk homologous kinase (Chk) and are regulated by stem cell factor in the megakaryoblastic cell line MO7e. (PubMed id 9255603)1, 9 Grgurevich S....McVicar D.W. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4145 HGNC: 6906 AceView: MATK Ensembl:ENSG00000007264 euGenes: HUgn4145
    ECgene: MATK Kegg: 4145 H-InvDB: MATK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MATK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MATK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MATK gene:
    Search GeneIP for patents involving MATK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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