Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MATK Gene

protein-coding   GIFtS: 64
GCID: GC19M003777

megakaryocyte-associated tyrosine kinase
 Explore 14 diseases affiliated with
MATK via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MATK    

Aliases
for MATK gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Megakaryocyte-Associated Tyrosine Kinase1 2     DKFZp434N12121
CTK1 2 3 5     MGC17081
HYL1 2 3 5     MGC21011
CHK1 2 3     Csk-Homologous Kinase2
HHYLTK1 2     Csk-Type Protein Tyrosine Kinase2
HYLTK1 2     Hydroxyaryl-Protein Kinase2
Lsk1 2     HYL Tyrosine Kinase2
Hematopoietic Consensus Tyrosine-Lacking Kinase2 3     Leukocyte Carboxyl-Terminal Src Kinase Related2
Protein Kinase HYL2 3     Megakaryocyte-Associated Tyrosine-Protein Kinase2
Tyrosine-Protein Kinase CTK2 3     Tyrosine Kinase MATK2
CSK Homologous Kinase2 3     Tyrosylprotein Kinase2
EC 2.7.10.23 8     EC 2.7.108

External Ids:    HGNC: 69061   Entrez Gene: 41452   Ensembl: ENSG000000072647   OMIM: 6000385   UniProtKB: P426793   

Export aliases for MATK gene to outside databases

Previous GC identifers: GC19M003870 GC19M003717 GC19M003728 GC19M003542


Summaries
for MATK gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MATK:
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural
features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of
myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site.
This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to
phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell
proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced
transcript variants that encode different isoforms have been described for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MATK_HUMAN, P42679
Function: Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase
activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue
which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation

Gene Wiki entry for MATK (Megakaryocyte-associated tyrosine kinase)


Genomic Views
for MATK gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MATK gene promoter:
         TBP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MATK promoter sequence
   Search SABiosciences Chromatin IP Primers for MATK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MATK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

MATK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MATK gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M003777:  view genomic region     (about GC identifiers)

Start:
 3,777,967 bp from pter      End:
 3,802,127 bp from pter
Size:
 24,161 bases      Orientation:
 minus strand

Proteins
for MATK gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MATK_HUMAN, P42679 (See protein sequence)
Recommended Name: Megakaryocyte-associated tyrosine-protein kinase  
Size: 507 amino acids; 56469 Da
Subunit: Interacts with KIT
Subcellular location: Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and
translocates to the cytoskeleton upon thrombin stimulation
3 PDB 3D structures from and Proteopedia for MATK:
1JWO (3D)        1X6G (3D)        3US4 (3D)    
Secondary accessions: B3KNZ9 Q9NST8
Alternative splicing: 3 isoforms:  P42679-1   P42679-2   P42679-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MATK: NX_P42679

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P42679

    • 4/5 DME Specific Peptides for MATK (P42679) (see all 5)
     KWTAPEA  RDLAARN  TSKSDVW  KSDVWSFG 

    MATK Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_002369.2  NP_647611.1  NP_647612.1  

    ENSEMBL proteins: 
     ENSP00000378481   ENSP00000308734   ENSP00000468030   ENSP00000378485   ENSP00000468576  
     ENSP00000465761   ENSP00000468465   ENSP00000467006   ENSP00000467992   ENSP00000465556  
     ENSP00000467472  
    Reactome Protein details: P42679
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): MATK
    OriGene Protein Over-expression Lysate (see all 2): MATK
    OriGene Custom Protein Services for MATK 
    GenScript Custom Purified and Recombinant Proteins Services for MATK
    Novus Biologicals MATK Proteins
    Novus Biologicals MATK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MATK

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0016020membrane IEA--


    MATK for ontologies           About GeneDecksing



    MATK Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MATK 
    GenScript Custom Superior Antibodies Services for MATK
    Novus Biologicals MATK Antibodies
    Abcam antibodies for MATK 
    Uscn Antibodies for MATK
    ThermoFisher Antibodies for MATK

    Assay Products for MATK: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MATK
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MATK

    Protein Domains /
    Families
    for MATK gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MATK for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR001452 SH3_domain
     IPR000719 Prot_kinase_cat_dom
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P42679

    ProtoNet protein and cluster: P42679

    4 Blocks protein families:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: MATK_HUMAN, P42679
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    Function
    for MATK gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MATK_HUMAN, P42679
    Function: Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase
    activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue
    which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for MATK:
    megakaryocyte-associated tyrosine kinase

    Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): MATK
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MATK
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MATK
    SwitchGear 3'UTR luciferase reporter plasmid: MATK 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MATK (see all 7)
    OriGene shRNA RFP: MATK
    OriGene siRNA: MATK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MATK

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MATK

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MATK (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MATK (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): MATK (NM_139354)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MATK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MATK 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MATK
    Search LifeMap BioReagents cell lines for MATK

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MATK

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004713protein tyrosine kinase activity TAS7530249
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--


    MATK for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MATK:
     Decreased Salmonella enterica   Decreased substrate adherent c 

    Animal Models:
         Mouse knock-outs for MATK: Matktm1Suda Matktm1Hua Matktm1Sor
         2 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Matk):
     hematopoietic system  normal 

    MATK for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MATK gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling events mediated by Stem cell factor receptor (c-Kit)
    		Signaling events mediated by Stem cell factor receptor (c-Kit)1.00
    		Kit Receptor Signaling Pathway0.37
    2IL-3 Signaling Pathway
    		IL-3 Signaling Pathway1.00
    3Neurotrophic factor-mediated Trk receptor signaling
    		Neurotrophic factor-mediated Trk receptor signaling1.00
    4Signaling by FGFR
    		Signaling by ERBB20.89
    5Signaling by GPCR
    		Signal Transduction0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4 BioSystems Pathways for MATK 
        Kit Receptor Signaling Pathway
    IL-3 Signaling Pathway
    Neurotrophic factor-mediated Trk receptor signaling
    Signaling events mediated by Stem cell factor receptor (c-Kit)

    2        Reactome Pathways for MATK
        Signaling by ERBB2
    Signal Transduction


    1         Kegg Pathway  (Kegg details for MATK):
        Neurotrophin signaling pathway


    MATK for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MATK

    5/14 Interacting proteins for MATK (P426791, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262, 3MINT-8038609 MINT-74582 I2D: score=4 
    PTK2BQ142892, 3MINT-8037577 MINT-8037562 I2D: score=3 
    EWSR1Q018443I2D: score=3 
    PXNP490233I2D: score=3 
    SRCP129313I2D: score=3 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS7530249
    GO:0007498mesoderm development TAS8288563
    GO:0008283cell proliferation TAS8288563
    GO:0008284positive regulation of cell proliferation TAS8999872


    MATK for ontologies           About GeneDecksing



    Drugs & Compounds
    for MATK gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MATK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MATK
    3 Novoseek chemical compound relationships for MATK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 63.5 83 16707123 (5), 10080957 (4), 11309195 (4), 8134117 (3) (see all 25)
    phosphotyrosine 58.6 2 10080957 (1), 8995444 (1)
    atp 0 2 15805285 (1)

    Search CenterWatch for drugs/clinical trials and news about MATK 

    Transcripts
    for MATK gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MATK gene (3 alternative transcripts): 
    NM_002378.3  NM_139354.2  NM_139355.2  

    Unigene Cluster for MATK:

    Megakaryocyte-associated tyrosine kinase
    Hs.631845  [show with all ESTs]
    Unigene Representative Sequence: BC000114
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395040(uc002lyu.3) ENST00000310132(uc002lyt.3 uc010dtq.3)
    ENST00000585778 ENST00000395045(uc002lyv.3) ENST00000590493 ENST00000588983
    ENST00000587180 ENST00000590028 ENST00000590849 ENST00000591059 ENST00000590980
    ENST00000590821 ENST00000592612 ENST00000592300

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): MATK
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MATK
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MATK
    SwitchGear 3'UTR luciferase reporter plasmid: MATK 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MATK (see all 7)
    OriGene shRNA RFP: MATK
    OriGene siRNA: MATK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MATK
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MATK (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MATK (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): MATK (NM_139354)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MATK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MATK 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MATK
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MATK
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MATK
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MATK

    Additional cDNA sequence: 

    AB593100.1 AK055395.1 AK225834.1 AK315646.1 AL137754.1 BC000114.1 BC003109.1 L18974.1 
    S71669.1 X77278.1 

    10 DOTS entries:

    DT.207287  DT.100751532  DT.92427625  DT.100751530  DT.92427626  DT.121463252  DT.121463261  DT.121463265 
    DT.40275271  DT.91855610 

    24/113 AceView cDNA sequences (see all 113):

    BM726725 X77278 CR614369 CR619542 BM313978 NM_139355 BC003109 BQ054024 
    BX283424 AL137754 BU070968 BQ549211 BU073359 AI357047 BU617908 CR610757 
    BE791829 BU077688 BI768288 NM_139354 BC000114 BI819535 BE783096 BI911599 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MATK (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^
    SP1:                          -     -                       -                                         -           -                                             
    SP2:                          -     -                       -                                         -           -                                             
    SP3:        -     -     -     -     -     -     -           -                                         -           -                                             
    SP4:                          -     -     -     -           -                                         -           -                                             
    SP5:                                                                                                                                            -               

    ExUns: 17 ^ 18 ^ 19a · 19b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for MATK

    Expression
    for MATK gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MATK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCAGCTGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MATK expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MATK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MATK

    SOURCE GeneReport for Unigene cluster: Hs.631845

    UniProtKB/Swiss-Prot: MATK_HUMAN, P42679
    Tissue specificity: Expressed in various myeloid cell lines, detected in brain and lung

        SABiosciences Custom PCR Arrays for MATK
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MATK
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MATK
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MATK
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MATK
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MATK

    Orthologs
    for MATK gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MATK gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MATK6
    		 Uncharacterized protein
    		 75(a)
    		 1 ↔ 1
    		 28(933358-938209)
    zebrafish
    (Danio rerio)    		 Actinopterygii matk6
    		 megakaryocyte-associated tyrosine kinase
    		 63(a)
    		 1 ↔ 1
    		 22(4677390-4692900)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Csk3 protein amino acid phosphorylation protein
    tyrosine more    		 48(a)   86E17   --
    worm
    (Caenorhabditis elegans)    		 Secernentea T25B9.53 Src homology domain 2, protein tyrosine
    kinase more    		 31(a)
    (best of 3)    		   IV(10752605-10754764)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G426406
    AT3G586406
    (see all 3)    		 Mitogen activated protein kinase kinase kinase-lik...
    Mitogen activated protein kinase kinase kinase-lik...
    (see all 3)    		 9(a)
    9(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 2(17758532-17764111)
    3(21686741-21693841)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 protein kinase domain containing protein, expresse...
    protein kinase domain containing protein, expresse...
    (see all 3)    		 9(a)
    9(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 1(27691513-27701432)
    2(8004980-8017343)


    ENSEMBL Gene Tree for MATK (if available)
    TreeFam Gene Tree for MATK (if available) 

    Paralogs
    for MATK gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MATK gene
    DSTYK2  FER2  CSK2  FES2  
    18/42 SIMAP similar genes for MATK using alignment to 10 protein entries:     MATK_HUMAN (see all proteins) (see all similar genes):
    lsk    CSK    EGFR    ABL1    BTK kinase deficient isoform 6    BTK kinase deficient isoform 2
    MARK2    BTK kinase deficient isoform 4    EPHA2    tec    DKFZp564L2416    TIE1
    DKFZp686M05208    BMX    FGFR2    FES    GRB2    BRSK2

    MATK for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MATK
    PGOHUM00000234119


    Genomic Variants
    for MATK gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/530 NCBI SNPs in MATK are shown (see all 530)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs351526051,2
    		C,F,--3777623(+) CAGTGG/ACCAGC 3 -- ds50019Minor allele frequency- A:0.34NA WA EA 370
    rs1866203081,2
    		--3777669(+) AAGATA/GGGGAG 3 -- ds50010--------
    rs1425731381,2
    		--3777706(+) AGGAGG/TCAGGG 3 -- ds50010--------
    rs1912956431,2
    		--3777941(+) GGGCAC/TGGGGA 3 -- ds50010--------
    rs1821911391,2
    		--3777959(+) ACACAC/GAGGCG 3 -- ds50010--------
    rs1465467631,2
    		--3778065(+) CTGCTC/GTGGGC 3 -- ut310--------
    rs1867946671,2
    		--3778091(+) TGCCCA/GCCTGG 3 -- ut310--------
    rs1996108551,2
    		--3778184(+) GGTCAC/GGGCTC 6 P syn10--------
    rs2020480021,2
    		--3778213(+) GGAGCC/TGTCGG 6 S G mis10--------
    rs353516801,2
    		C,F,--3778219(-) AGGACG/ACCGAC 6 /T /A mis14Minor allele frequency- A:0.04NA 200

    HapMap Linkage Disequilibrium report for MATK (3777967 - 3802127 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MATK
         1 CNV: 30067

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MATK
    DNA2.0 Custom Variant and Variant Library Synthesis for MATK

    Disorders / Diseases
    for MATK gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MATK for disorders           About GeneDecksing

    OMIM gene information: 600038    OMIM disorders: --

    14 diseases for MATK:    About MalaCards
    breast cancer    preretinal fibrosis    spondylolisthesis    macular degeneration
    hyperopia    astigmatism    myopia    endocarditis
    colon cancer    pharyngitis    pancreatic cancer    pancreatitis
    ataxia    neuroblastoma

    5 diseases from the University of Copenhagen DISEASES database for MATK:
    Astigmatism     Hyperopia     Preretinal fibrosis     Spondylolisthesis
    Myopia

    3 Novoseek disease relationships for MATK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 22.1 23 9461599 (5), 11445575 (4), 12122014 (3), 8999872 (3) (see all 6)
    tumors 0 5 15104145 (1), 11445575 (1), 15329911 (1)
    cancer 0 4 16243715 (2), 12429987 (1)

    Tumor Gene Database (TGDB): MATK

    Export disorders for MATK gene to outside databases

    Publications
    for MATK gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MATK gene, integrated from 9 sources (see all 68):
    (articles sorted by number of sources associating them with MATK)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel tyrosine kinase from megakaryocytes. (PubMed id 8288563)1, 2, 3, 9 Bennett B.D.... Avraham H. (1994)
    2. Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product. (PubMed id 7530249)1, 2, 3, 9 Avraham S....Avraham H. (1995)
    3. Characterization of mouse non-receptor tyrosine kinase gene, HYL. (PubMed id 7936664)1, 2, 9 Hamaguchi I.... Suda T. (1994)
    4. Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase). (PubMed id 8134117)1, 2, 9 Sakano S.... Suda T. (1994)
    5. Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. (PubMed id 9038210)1, 2, 9 Price D.J....Avraham H. (1997)
    6. Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets. (PubMed id 9171348)1, 2, 9 Hirao A....Yamaguchi N. (1997)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The Csk-like proteins Lsk, Hyl, and Matk represent the same Csk homologous kinase (Chk) and are regulated by stem cell factor in the megakaryoblastic cell line MO7e. (PubMed id 9255603)1, 9 Grgurevich S....McVicar D.W. (1997)

    External Searches for MATK gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MATK gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4145 HGNC: 6906 AceView: MATK Ensembl:ENSG00000007264 euGenes: HUgn4145
    ECgene: MATK Kegg: 4145 H-InvDB: MATK

    Other Databases showing MATK gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MATK gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MATK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MATK Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MATK gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MATK gene:
    Search GeneIP for patents involving MATK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MATK gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for MATK  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MATK   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MATK  
     OriGene Protein Over-expression Lysate for MATK   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for MATK   OriGene 3'-UTR Clone for MATK  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MATK   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MATK  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for MATK   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MATK   OriGene Custom Protein Services for MATK  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MATK
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MATK
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MATK
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MATK
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MATK
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MATK
     GenScript Custom Purified and Recombinant Proteins Services for MATK GenScript cDNA clones with any tag delivered in your preferred vector for MATK
     GenScript Custom Assay Services for MATK GenScript Custom Superior Antibodies Services for MATK
     GenScript Custom overexpressing Cell Line Services for MATK CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MATK promoter
     Search Chromatin IP Primers for MATK
     RT2 qPCR Primer Assay in human, mouse, rat MATK
     GNC Network for MATK
     SABiosciences Custom PCR Arrays for MATK
     Search Tocris compounds for MATK
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MATK antibodies
     MATK proteins
     MATK lysates
     Antibodies for MATK
     See all of Abcam's Antibodies, Kits and Proteins for MATK
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     MATK Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for MATK
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MATK
     SwitchGear 3'UTR luciferase reporter plasmids for MATK
     SwitchGear Promoter luciferase reporter plasmids for MATK
     ThermoFisher Antibodies for MATK
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MATK
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      MATK gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4