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Aliases for MAT2B Gene

Aliases for MAT2B Gene

  • Methionine Adenosyltransferase 2B 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 23E, Member 1 2 3
  • Putative DTDP-4-Keto-6-Deoxy-D-Glucose 4-Reductase 3 4
  • Methionine Adenosyltransferase II, Beta 2 3
  • MAT II Beta 3 4
  • TGR 3 4
  • Beta Regulatory Subunit Of Methionine Adenosyltransferase 3
  • Methionine Adenosyltransferase 2 Subunit Beta 3
  • DTDP-4-Keto-6-Deoxy-D-Glucose 4-Reductase 3
  • Methionine Adenosyltransferase II Beta 4
  • Putative Protein Product Of Nbla02999 3
  • Testicular Tissue Protein Li 118 3
  • MATIIbeta 3
  • Nbla02999 3
  • SDR23E1 3
  • MAT-II 3

External Ids for MAT2B Gene

Previous GeneCards Identifiers for MAT2B Gene

  • GC05P163135
  • GC05P162865
  • GC05P162911
  • GC05P162862
  • GC05P162930
  • GC05P158029

Summaries for MAT2B Gene

Entrez Gene Summary for MAT2B Gene

  • The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

GeneCards Summary for MAT2B Gene

MAT2B (Methionine Adenosyltransferase 2B) is a Protein Coding gene. Among its related pathways are Deubiquitination and Methylation Pathways. GO annotations related to this gene include enzyme binding and coenzyme binding.

UniProtKB/Swiss-Prot for MAT2B Gene

  • Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAT2B Gene

Genomics for MAT2B Gene

Regulatory Elements for MAT2B Gene

Enhancers for MAT2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G163457 1.4 ENCODE dbSUPER 17.2 -42.4 -42412 6.0 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CCNG1 MAT2B HMMR-AS1 LOC105377700 NUDCD2 HMMR
GH05G163502 1.4 ENCODE dbSUPER 7.4 +3.4 3431 8.7 HDGF HNRNPUL1 PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 MAT2B HMMR CCNG1 NUDCD2 GC05P163619
GH05G163773 0.4 dbSUPER 5.7 +271.9 271916 2.1 NFE2 MAT2B RNU6-168P GC05M163722 GC05M163721
GH05G163533 0.9 Ensembl ENCODE 0.3 +31.4 31443 2.3 MAX FEZF1 RBBP5 CHD7 ZNF316 HDAC2 POU5F1 KDM1A EMSY EZH2 MAT2B GC05P163619
GH05G163565 1.1 Ensembl ENCODE 0.2 +63.2 63169 1.3 ELF3 FOXA2 ARID4B ZNF48 RARA GATA2 FOS RELB IKZF2 CREM GC05P163619 MAT2B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAT2B on UCSC Golden Path with GeneCards custom track

Genomic Location for MAT2B Gene

Chromosome:
5
Start:
163,503,064 bp from pter
End:
163,519,353 bp from pter
Size:
16,290 bases
Orientation:
Plus strand

Genomic View for MAT2B Gene

Genes around MAT2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAT2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAT2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAT2B Gene

Proteins for MAT2B Gene

  • Protein details for MAT2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZL9-MAT2B_HUMAN
    Recommended name:
    Methionine adenosyltransferase 2 subunit beta
    Protein Accession:
    Q9NZL9
    Secondary Accessions:
    • B2R5Y6
    • Q1WAI7
    • Q27J92
    • Q3LIE8
    • Q567T7
    • Q6NYC7
    • Q9BS89
    • Q9H3E1
    • Q9UJ54

    Protein attributes for MAT2B Gene

    Size:
    334 amino acids
    Molecular mass:
    37552 Da
    Quaternary structure:
    • Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain (PubMed:10644686, PubMed:23189196). Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain (PubMed:25075345). NADP binding increases the affinity for MAT2A (PubMed:23189196).
    Miscellaneous:
    • Its expression in hepatoma cell lines may lead to increase DNA synthesis and thereby participate in cell proliferation.
    SequenceCaution:
    • Sequence=AAG39296.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAT2B Gene

    Alternative splice isoforms for MAT2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAT2B Gene

Post-translational modifications for MAT2B Gene

  • Ubiquitination at Lys209, posLast=245245, Lys316, and posLast=326326
  • Modification sites at PhosphoSitePlus

Other Protein References for MAT2B Gene

No data available for DME Specific Peptides for MAT2B Gene

Domains & Families for MAT2B Gene

Gene Families for MAT2B Gene

Protein Domains for MAT2B Gene

Graphical View of Domain Structure for InterPro Entry

Q9NZL9

UniProtKB/Swiss-Prot:

MAT2B_HUMAN :
  • Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
Family:
  • Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
genes like me logo Genes that share domains with MAT2B: view

Function for MAT2B Gene

Molecular function for MAT2B Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511).

Gene Ontology (GO) - Molecular Function for MAT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25075345
GO:0019899 enzyme binding IPI 10644686
GO:0048270 methionine adenosyltransferase regulator activity IDA 10644686
genes like me logo Genes that share ontologies with MAT2B: view
genes like me logo Genes that share phenotypes with MAT2B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MAT2B

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAT2B Gene

Localization for MAT2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAT2B gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 3
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MAT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IC 10644686
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0048269 methionine adenosyltransferase complex IDA 10644686
genes like me logo Genes that share ontologies with MAT2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAT2B Gene

Pathways & Interactions for MAT2B Gene

genes like me logo Genes that share pathways with MAT2B: view

UniProtKB/Swiss-Prot Q9NZL9-MAT2B_HUMAN

  • Pathway: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.

Gene Ontology (GO) - Biological Process for MAT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006556 S-adenosylmethionine biosynthetic process IEA --
GO:0006730 one-carbon metabolic process IEA --
GO:0032259 methylation TAS --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with MAT2B: view

No data available for SIGNOR curated interactions for MAT2B Gene

Drugs & Compounds for MAT2B Gene

(5) Drugs for MAT2B Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Methionine Approved Nutra Enzyme, substrate 0
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
S-Adenosylmethionine Approved Nutra 0

(4) Additional Compounds for MAT2B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
Se-Adenosylselenomethionine
selenomethionine
  • (+-)-Selenomethionine
  • (2S)-2-amino-4-(methylseleno)butanoate
  • (2S)-2-amino-4-(methylseleno)butanoic acid
  • (S)-2-amino-4-(methylseleno)-Butanoate
  • (S)-2-amino-4-(methylseleno)-Butanoic acid
3211-76-5
genes like me logo Genes that share compounds with MAT2B: view

Transcripts for MAT2B Gene

Unigene Clusters for MAT2B Gene

Methionine adenosyltransferase II, beta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MAT2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAT2B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - - -
SP2: -
SP3:
SP4: -
SP5: - -
SP6: - - -

Relevant External Links for MAT2B Gene

GeneLoc Exon Structure for
MAT2B
ECgene alternative splicing isoforms for
MAT2B

Expression for MAT2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAT2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAT2B Gene

This gene is overexpressed in Lavage (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAT2B Gene



Protein tissue co-expression partners for MAT2B Gene

NURSA nuclear receptor signaling pathways regulating expression of MAT2B Gene:

MAT2B

SOURCE GeneReport for Unigene cluster for MAT2B Gene:

Hs.54642

mRNA Expression by UniProt/SwissProt for MAT2B Gene:

Q9NZL9-MAT2B_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for MAT2B Gene

  • Nervous system(4.9)
  • Heart(4.3)
  • Skin(4.3)
  • Pancreas(4.2)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with MAT2B: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAT2B Gene

Orthologs for MAT2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAT2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAT2B 34 35
  • 99.36 (n)
dog
(Canis familiaris)
Mammalia MAT2B 34 35
  • 93.11 (n)
cow
(Bos Taurus)
Mammalia MAT2B 34 35
  • 92.81 (n)
oppossum
(Monodelphis domestica)
Mammalia MAT2B 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAT2B 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mat2b 34 16 35
  • 88.72 (n)
rat
(Rattus norvegicus)
Mammalia Mat2b 34
  • 88.62 (n)
chicken
(Gallus gallus)
Aves MAT2B 34 35
  • 79.83 (n)
lizard
(Anolis carolinensis)
Reptilia MAT2B 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mat2b 34
  • 72.85 (n)
Str.19105 34
zebrafish
(Danio rerio)
Actinopterygii mat2b 34 35
  • 63.68 (n)
wufb48h02 34
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G00560 34
  • 42.25 (n)
rice
(Oryza sativa)
Liliopsida Os02g0826200 34
  • 42.82 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01177 34
  • 50.76 (n)
Species where no ortholog for MAT2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAT2B Gene

ENSEMBL:
Gene Tree for MAT2B (if available)
TreeFam:
Gene Tree for MAT2B (if available)

Paralogs for MAT2B Gene

No data available for Paralogs for MAT2B Gene

Variants for MAT2B Gene

Sequence variations from dbSNP and Humsavar for MAT2B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000078228 -- 163,509,954(+) ACTAT(C/G)TTTCC intron-variant
rs1000091216 -- 163,501,838(+) TCTAC(C/T)AAAAA upstream-variant-2KB
rs1000183993 -- 163,501,092(+) TTCTG(A/T)CTAAT upstream-variant-2KB
rs1000314529 -- 163,519,175(+) TTACT(A/T)CTTTT utr-variant-3-prime
rs1000324252 -- 163,507,773(+) AGAGT(A/G)TTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAT2B Gene

Variant ID Type Subtype PubMed ID
nsv1017056 CNV gain 25217958
nsv1029437 CNV gain 25217958
nsv830538 CNV gain+loss 17160897

Variation tolerance for MAT2B Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAT2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAT2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAT2B Gene

Disorders for MAT2B Gene

Relevant External Links for MAT2B

Genetic Association Database (GAD)
MAT2B
Human Genome Epidemiology (HuGE) Navigator
MAT2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAT2B

No disorders were found for MAT2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAT2B Gene

Publications for MAT2B Gene

  1. Regulation of the human MAT2B gene encoding the regulatory beta subunit of methionine adenosyltransferase, MAT II. (PMID: 11337507) LeGros L. … Kotb M. (J. Biol. Chem. 2001) 3 4 22 25 64
  2. Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma. (PMID: 12671891) Martinez-Chantar M.L. … Mato J.M. (Gastroenterology 2003) 3 4 22 64
  3. Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II). (PMID: 10644686) LeGros H.L. … Kotb M. (J. Biol. Chem. 2000) 2 3 4 64
  4. Structure and function study of the complex that synthesizes S- adenosylmethionine. (PMID: 25075345) Murray B. … Rojas A.L. (IUCrJ 2014) 3 4 64
  5. Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits. (PMID: 23425511) Shafqat N. … Yue W.W. (Biochem. J. 2013) 3 4 64

Products for MAT2B Gene

Sources for MAT2B Gene

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