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MAT2B Gene

protein-coding   GIFtS: 57
GCID: GC05P162930

Methionine Adenosyltransferase II, Beta

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Methionine Adenosyltransferase II, Beta1 2     Nbla029992
Putative DTDP-4-Keto-6-Deoxy-D-Glucose 4-Reductase2 3     SDR23E12
TGR2 3     Beta Regulatory Subunit Of Methionine Adenosyltransferase2
MAT II Beta2 3     DTDP-4-Keto-6-Deoxy-D-Glucose 4-Reductase2
Member 11     Methionine Adenosyltransferase 2 Subunit Beta2
Short Chain Dehydrogenase/Reductase Family 23E1     Putative Protein Product Of Nbla029992
MAT-II2     Short Chain Dehydrogenase/Reductase Family 23E, Member 12
MATIIbeta2     Methionine Adenosyltransferase II Beta3

External Ids:    HGNC: 69051   Entrez Gene: 274302   Ensembl: ENSG000000382747   OMIM: 6055275   UniProtKB: Q9NZL93   

Export aliases for MAT2B gene to outside databases

Previous GC identifers: GC05P163135 GC05P163523 GC05P162865 GC05P162911 GC05P162862 GC05P158029


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAT2B Gene:
The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the
biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT.
Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq,
Nov 2012)

GeneCards Summary for MAT2B Gene:
MAT2B (methionine adenosyltransferase II, beta) is a protein-coding gene. GO annotations related to this gene include dTDP-4-dehydrorhamnose reductase activity and methionine adenosyltransferase regulator activity.

UniProtKB/Swiss-Prot: MAT2B_HUMAN, Q9NZL9
Function: Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes
the formation of S-adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine
synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S-adenosylmethionine
inhibition




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAT2B gene promoter:
         RP58   Tal-1   FOXO4   c-Myb   Evi-1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAT2B promoter sequence
   Search Chromatin IP Primers for MAT2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAT2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q34-q35   Ensembl cytogenetic band:  5q34   HGNC cytogenetic band: 5q34-q35

MAT2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAT2B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P162930:  view genomic region     (about GC identifiers)

Start:
162,930,120 bp from pter      End:
162,946,342 bp from pter
Size:
16,223 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MAT2B_HUMAN, Q9NZL9 (See protein sequence)
Recommended Name: Methionine adenosyltransferase 2 subunit beta  
Size: 334 amino acids; 37552 Da
Subunit: Heterotetramer composed of 2 catalytic alpha subunits (alpha and alpha') (MAT2A) and 1 copy of beta
subunit (MAT2B)
Miscellaneous: Its expression in hepatoma cell lines may lead to increase DNA synthesis and thereby participate in
cell proliferation
Sequence caution: Sequence=AAG39296.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for MAT2B:
2YDX (3D)        2YDY (3D)    
Secondary accessions: B2R5Y6 Q1WAI7 Q27J92 Q3LIE8 Q567T7 Q6NYC7 Q9BS89 Q9H3E1 Q9UJ54
Alternative splicing: 5 isoforms:  Q9NZL9-1   Q9NZL9-2   Q9NZL9-3   Q9NZL9-4   Q9NZL9-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAT2B: NX_Q9NZL9

Explore proteomics data for MAT2B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys209, Lys245, Lys316, Lys326
  • Modification sites at PhosphoSitePlus

  • See MAT2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_037415.1  NP_877725.1  

    ENSEMBL proteins: 
     ENSP00000280969   ENSP00000325425   ENSP00000397371   ENSP00000428046   ENSP00000431071  
    Reactome Protein details: Q9NZL9

    MAT2B Human Recombinant Protein Products:

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    Novus Biologicals MAT2B Lysates
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MAT2B
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for MAT2B (20 products) 

     
    antibodies-online peptides for MAT2B

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    antibodies-online antibodies for MAT2B (24 products) 

    MAT2B Assay Products:

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    antibodies-online kits for MAT2B (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SDRE: Short chain dehydrogenase/reductase superfamily / Extended SDR fold

    2 InterPro protein domains:
     IPR005913 dTDP_dehydrorham_reduct
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9NZL9

    ProtoNet protein and cluster: Q9NZL9

    1 Blocks protein domain: IPB005913 dTDP-4-dehydrorhamnose reductase

    UniProtKB/Swiss-Prot: MAT2B_HUMAN, Q9NZL9
    Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily


    Find genes that share domains with MAT2B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAT2B_HUMAN, Q9NZL9
    Function: Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes
    the formation of S-adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine
    synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S-adenosylmethionine
    inhibition

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:00038543-beta-hydroxy-delta5-steroid dehydrogenase activity ----
    GO:0008831dTDP-4-dehydrorhamnose reductase activity IEA--
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ----
    GO:0019899enzyme binding IPI10644686
         
    Find genes that share ontologies with MAT2B           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MAT2B

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAT2B:
    hsa-mir-26b-5p (MIRT029818), hsa-mir-375 (MIRT019945), hsa-mir-155-5p (MIRT020796), hsa-let-7b-5p (MIRT032407)

    Block miRNA regulation of human, mouse, rat MAT2B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAT2B (see all 33):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-485-3p hsa-miR-301a hsa-miR-138-2* hsa-miR-93 hsa-miR-330-3p hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidMAT2B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MAT2B

    Gene Editing
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    Sino Biological Human cDNA Clone for MAT2B
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    Addgene plasmids for MAT2B 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAT2B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    mitochondrion2
    cytoskeleton1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IC10644686
    GO:0005634nucleus IDA--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0048269methionine adenosyltransferase complex IDA10644686

    Find genes that share ontologies with MAT2B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAT2B About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    2Sulfur amino acid metabolism
    Sulfur amino acid metabolism0.35
    Cysteine and methionine metabolism0.35
    3Biological oxidations
    Biological oxidations0.56
    Methylation0.00
    Phase II conjugation0.56
    4One carbon pool by folate
    One Carbon Metabolism0.53
    Trans-sulfuration and one carbon metabolism0.43
    5superpathway of methionine degradation
    superpathway of methionine degradation
    cysteine biosynthesis III (mammalia)0.00


    Find genes that share SuperPaths with MAT2B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for MAT2B (see all 7)
        One Carbon Metabolism
    Trans-sulfuration pathway
    methionine degradation I (to homocysteine)
    Trans-sulfuration and one carbon metabolism
    superpathway of methionine degradation


    2 Reactome Pathways for MAT2B
        Sulfur amino acid metabolism
    Methylation


    3 Kegg Pathways  (Kegg details for MAT2B):
        Cysteine and methionine metabolism
    Metabolic pathways
    Biosynthesis of amino acids

    UniProtKB/Swiss-Prot: MAT2B_HUMAN, Q9NZL9
    Pathway: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine:
    step 1/1

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAT2B
    Interactions:

        Search GeneGlobe Interaction Network for MAT2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAT2B (Q9NZL93 ENSP000003254254) via UniProtKB, MINT, STRING, and/or I2D (see all 42)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAT2AP311533, ENSP000003031474I2D: score=2 STRING: ENSP00000303147
    CAMKK2Q96RR43I2D: score=1 
    WDR45Q9Y4843I2D: score=1 
    BHMTENSP000002743534STRING: ENSP00000274353
    BHMT2ENSP000002551924STRING: ENSP00000255192
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0006556S-adenosylmethionine biosynthetic process IEA--
    GO:0006694steroid biosynthetic process ----
    GO:0006730one-carbon metabolic process IEA--
    GO:0006805xenobiotic metabolic process TAS--

    Find genes that share ontologies with MAT2B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAT2B

    9 HMDB Compounds for MAT2B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Methionine(2S)-2-amino-4-(methylsulfanyl)butanoic acid (see all 54)63-68-3--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    Se-Adenosylselenomethionine ----
    Selenomethionine(+-)-Selenomethionine (see all 26)3211-76-5--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for MAT2B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Methionine(S)-2-amino-4-(methylthio)butanoic acid (see all 6)63-68-3enzymesubstrate17139284 11337507 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAT2B gene (2 alternative transcripts): 
    NM_013283.4  NM_182796.2  

    Unigene Cluster for MAT2B:

    Methionine adenosyltransferase II, beta
    Hs.54642  [show with all ESTs]
    Unigene Representative Sequence: AB073390
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280969(uc003lzj.3) ENST00000519719 ENST00000321757(uc003lzk.3)
    ENST00000421814 ENST00000518095(uc003lzl.1) ENST00000523606 ENST00000520449
    ENST00000521838(uc003lzm.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MAT2B (see all 33):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-485-3p hsa-miR-301a hsa-miR-138-2* hsa-miR-93 hsa-miR-330-3p hsa-miR-526b*
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      QuantiFast Probe-based Assays in human, mouse, rat MAT2B

    Additional mRNA sequence: 

    AB073390.1 AF113225.1 AF182814.1 AJ243721.1 AK096178.1 AK291919.1 AK294069.1 AK312365.1 
    AL136664.1 AY358695.1 BC005218.1 BC066645.1 BC093030.1 DQ395260.1 DQ413182.1 DQ413183.1 

    12 DOTS entries:

    DT.453613  DT.40121770  DT.91759828  DT.100817406  DT.100817405  DT.100832330  DT.100036937  DT.95116883 
    DT.120841320  DT.95116862  DT.95116886  DT.97795674 

    Selected AceView cDNA sequences (see all 316):

    AI358182 AJ430429 BM128105 F02683 BM807060 AA779556 BE671097 AA748545 
    AA576719 CA397433 BF941653 AA634119 W20302 BM980940 AA811454 AI022959 
    AA541267 BP343302 AA552601 CB126825 AI637725 CB121804 BQ574443 BI818689 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAT2B (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:              -     -     -           -                                             
    SP2:                                      -                                             
    SP3:                                                                                    
    SP4:                                      -                                             
    SP5:                                      -     -                                       


    ECgene alternative splicing isoforms for MAT2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAT2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATACATAC
    MAT2B Expression
    About this image

    MAT2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAT2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.54642

    UniProtKB/Swiss-Prot: MAT2B_HUMAN, Q9NZL9
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAT2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAT2B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mat2b1 , 5 methionine adenosyltransferase II, beta1, 5 88.72(n)1
    94.31(a)1
      11 (24.40 cM)5
    1086451  NM_134017.21  NP_598778.11 
     406793145 
    chicken
    (Gallus gallus)
    Aves MAT2B1 methionine adenosyltransferase II, beta 79.83(n)
    88.22(a)
      416165  XM_414497.4  XP_414497.4 
    lizard
    (Anolis carolinensis)
    Reptilia MAT2B6
    methionine adenosyltransferase II, beta
    81(a)
    1 ↔ 1
    1(108114491-108127388)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.191052 Transcribed sequence with moderate similarity to protein more 78.31(n)    BX773905.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb48h022 wufb48h02 73.73(n)   322067  BI708448.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G005601 AT4G00560 42.25(n)
    29.17(a)
      827978  NM_116280.3  NP_191965.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g08262001 Os02g0826200 42.82(n)
    30.21(a)
      4331215  NM_001055120.1  NP_001048585.1 


    ENSEMBL Gene Tree for MAT2B (if available)
    TreeFam Gene Tree for MAT2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for MAT2B (see all 487)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs600095831,2
    C--158038143(+) TTTTT-/TT/TTT
            
    GGAAG
    2 -- int11NA 2
    rs1460960911,2
    --162928144(+) GTCTTC/TACTTC 1 -- us2k10--------
    rs1843671711,2
    --162928317(+) ATTCTC/GTTAGG 1 -- us2k10--------
    rs77226241,2
    C,A--162928463(+) CCCAGC/GACCTT 1 -- us2k10--------
    rs77085221,2
    C,A--162928471(+) CTTGGG/TAGGCT 1 -- us2k10--------
    rs1891600351,2
    --162928486(+) CAGGCA/GGATCA 1 -- us2k10--------
    rs1924068131,2
    --162928614(+) GCTGAG/TGAAGG 1 -- us2k10--------
    rs1856951041,2
    --162928679(+) ACATTA/CCAGCC 1 -- us2k10--------
    rs1445925131,2
    --162928722(+) AATAAA/TTAAGG 1 -- us2k10--------
    rs1112885861,2
    C,F--162928809(+) CGAGAC/TCATCC 1 -- us2k12Minor allele frequency- T:0.50WA NA 4

    HapMap Linkage Disequilibrium report for MAT2B (162930120 - 162946342 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MAT2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830538CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAT2B
    DNA2.0 Custom Variant and Variant Library Synthesis for MAT2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605527    OMIM disorders: --


    Find genes that share disorders with MAT2B           About GenesLikeMe

    Genetic Association Database (GAD): MAT2B
    Human Genome Epidemiology (HuGE) Navigator: MAT2B (7 documents)

    Export disorders for MAT2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAT2B gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with MAT2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of the human MAT2B gene encoding the regulatory beta subunit of methionine adenosyltransferase, MAT II. (PubMed id 11337507)1, 2, 7, 9 LeGros L.... Kotb M. (J. Biol. Chem. 2001)
    2. Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II). (PubMed id 10644686)1, 2, 3 LeGros H.L.... Kotb M. (J. Biol. Chem. 2000)
    3. Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma. (PubMed id 12671891)1, 2, 9 Martinez-Chantar M.L.... Mato J.M. (Gastroenterology 2003)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Genetic association study of putative functional single nucleotide polymorphisms of genes in folate metabolism and spina bifida. (PubMed id 19683694)1, 4 Martinez C.A....Au K.S. (Am. J. Obstet. Gynecol. 2009)
    8. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
    9. Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study. (PubMed id 19048631)1, 4 Boyles A.L....Lie R.T. (Genet. Epidemiol. 2009)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27430 HGNC: 6905 AceView: MAT2B Ensembl:ENSG00000038274 euGenes: HUgn27430
    ECgene: MAT2B Kegg: 27430 H-InvDB: MAT2B

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAT2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MAT2B gene:
    Search GeneIP for patents involving MAT2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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