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Aliases for MAT2A Gene

Aliases for MAT2A Gene

  • Methionine Adenosyltransferase 2A 2 3
  • Methionine Adenosyltransferase II, Alpha 2 3 5
  • Methionine Adenosyltransferase 2 3 4
  • AdoMet Synthase 2 3 4
  • EC 4 63
  • MAT-II 3 4
  • MAT 2 3 4
  • MATA2 3 4
  • Methionine Adenosyltransferase II 4
  • Testicular Tissue Protein Li 121 3
  • AdoMet Synthetase 2 3
  • MATII 3
  • SAMS2 3
  • AMS2 4

External Ids for MAT2A Gene

Previous GeneCards Identifiers for MAT2A Gene

  • GC02P085661
  • GC02P086060
  • GC02P085740
  • GC02P085677
  • GC02P085619
  • GC02P085766
  • GC02P085663

Summaries for MAT2A Gene

Entrez Gene Summary for MAT2A Gene

  • The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]

GeneCards Summary for MAT2A Gene

MAT2A (Methionine Adenosyltransferase 2A) is a Protein Coding gene. Diseases associated with MAT2A include Acute Maxillary Sinusitis and Glycine N-Methyltransferase Deficiency. Among its related pathways are Phase II conjugation and S-adenosyl-L-methionine biosynthesis. GO annotations related to this gene include methionine adenosyltransferase activity. An important paralog of this gene is MAT1A.

UniProtKB/Swiss-Prot for MAT2A Gene

  • Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAT2A Gene

Genomics for MAT2A Gene

Regulatory Elements for MAT2A Gene

Enhancers for MAT2A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAT2A on UCSC Golden Path with GeneCards custom track

Promoters for MAT2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAT2A on UCSC Golden Path with GeneCards custom track

Genomic Location for MAT2A Gene

85,538,978 bp from pter
85,545,280 bp from pter
6,303 bases
Plus strand

Genomic View for MAT2A Gene

Genes around MAT2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAT2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAT2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAT2A Gene

Proteins for MAT2A Gene

  • Protein details for MAT2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    S-adenosylmethionine synthase isoform type-2
    Protein Accession:
    Secondary Accessions:
    • A8K511
    • B4DN45
    • D6W5L1
    • Q53SP5

    Protein attributes for MAT2A Gene

    395 amino acids
    Molecular mass:
    43661 Da
    Name=K(+); Xref=ChEBI:CHEBI:29103;
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Co(2+); Xref=ChEBI:CHEBI:48828;
    Quaternary structure:
    • Heterotetramer composed of 2 catalytic alpha subunits (alpha and alpha) (MAT2A) and 1 copy of beta subunit (MAT2B).

    Three dimensional structures from OCA and Proteopedia for MAT2A Gene

    Alternative splice isoforms for MAT2A Gene


neXtProt entry for MAT2A Gene

Proteomics data for MAT2A Gene at MOPED

Post-translational modifications for MAT2A Gene

  • The alpha subunit is a post-translationally modified version of MAT2A.
  • Ubiquitination at Lys 61, Lys 81, Lys 97, Lys 228, Lys 234, Lys 350, and Lys 367
  • Modification sites at PhosphoSitePlus

Other Protein References for MAT2A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MAT2A Gene

Suggested Antigen Peptide Sequences for MAT2A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AdoMet synthase family.
  • Belongs to the AdoMet synthase family.
genes like me logo Genes that share domains with MAT2A: view

No data available for Gene Families for MAT2A Gene

Function for MAT2A Gene

Molecular function for MAT2A Gene

GENATLAS Biochemistry:
methionine adenosyltransferase,extrahepatic isoform,catalytic specific,subunit alpha,expressed in fetal liver,brain,testis,kidney,lymphocytes,sulfur aminoacid metabolism
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine.
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

Enzyme Numbers (IUBMB) for MAT2A Gene

genes like me logo Genes that share phenotypes with MAT2A: view

Animal Models for MAT2A Gene

MGI Knock Outs for MAT2A:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAT2A

miRNA for MAT2A Gene

miRTarBase miRNAs that target MAT2A

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAT2A Gene

Localization for MAT2A Gene

Subcellular locations from

Jensen Localization Image for MAT2A Gene COMPARTMENTS Subcellular localization image for MAT2A gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAT2A Gene

Pathways & Interactions for MAT2A Gene

genes like me logo Genes that share pathways with MAT2A: view

UniProtKB/Swiss-Prot P31153-METK2_HUMAN

  • Pathway: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.

Gene Ontology (GO) - Biological Process for MAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
genes like me logo Genes that share ontologies with MAT2A: view

No data available for SIGNOR curated interactions for MAT2A Gene

Drugs & Compounds for MAT2A Gene

(8) Drugs for MAT2A Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra Target, cofactor 0
L-Methionine Approved Nutra Enzyme, substrate 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0
Potassium Experimental Pharma 0

(5) Additional Compounds for MAT2A Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • (+-)-Selenomethionine
  • (2S)-2-amino-4-(methylseleno)butanoate
  • (2S)-2-amino-4-(methylseleno)butanoic acid
  • (S)-2-amino-4-(methylseleno)-Butanoate
  • (S)-2-amino-4-(methylseleno)-Butanoic acid
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with MAT2A: view

Transcripts for MAT2A Gene

Unigene Clusters for MAT2A Gene

Methionine adenosyltransferase II, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAT2A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1: - - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: -
SP8: -

Relevant External Links for MAT2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAT2A Gene

mRNA expression in normal human tissues for MAT2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAT2A Gene

SOURCE GeneReport for Unigene cluster for MAT2A Gene Hs.516157

genes like me logo Genes that share expression patterns with MAT2A: view

Protein tissue co-expression partners for MAT2A Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MAT2A Gene

Orthologs for MAT2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAT2A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MAT2A 35
  • 94.6 (n)
  • 99.24 (a)
MAT2A 36
  • 99 (a)
(Canis familiaris)
Mammalia MAT2A 35
  • 95.02 (n)
  • 99.75 (a)
MAT2A 36
  • 100 (a)
(Mus musculus)
Mammalia Mat2a 35
  • 93.16 (n)
  • 99.49 (a)
Mat2a 16
Mat2a 36
  • 99 (a)
(Pan troglodytes)
Mammalia MAT2A 35
  • 99.49 (n)
  • 100 (a)
MAT2A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mat2a 35
  • 93.5 (n)
  • 98.48 (a)
(Monodelphis domestica)
Mammalia MAT2A 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia MAT2A 36
  • 98 (a)
(Gallus gallus)
Aves -- 36
  • 72 (a)
(Anolis carolinensis)
Reptilia MAT2A 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mat2a 35
  • 79.92 (n)
  • 92.91 (a)
MGC76253 35
African clawed frog
(Xenopus laevis)
Amphibia m(2)21ab-prov 35
(Danio rerio)
Actinopterygii mat2ab 35
  • 75.51 (n)
  • 90.06 (a)
mat2aa 36
  • 92 (a)
mat2ab 36
  • 90 (a)
fruit fly
(Drosophila melanogaster)
Insecta M(2)21AB 37
  • 74 (a)
Sam-S 35
  • 67.71 (n)
  • 74.61 (a)
Sam-S 36
  • 69 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009447 35
  • 65.56 (n)
  • 74.1 (a)
(Caenorhabditis elegans)
Secernentea C06E7.1a 37
  • 74 (a)
C49F5.1 37
  • 67 (a)
sams-3 35
  • 66.67 (n)
  • 74.27 (a)
sams-1 36
  • 63 (a)
sams-3 36
  • 69 (a)
sams-4 36
  • 68 (a)
sams-5 36
  • 67 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR692C 35
  • 60.67 (n)
  • 67.72 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C01782g 35
  • 64.46 (n)
  • 68.25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAM1 35
  • 63.51 (n)
  • 68.16 (a)
SAM1 36
  • 67 (a)
SAM2 36
  • 66 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MAT3 35
  • 63.23 (n)
  • 66.93 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02657 35
  • 64.79 (n)
  • 69.74 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sam1 35
  • 65.26 (n)
  • 69.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10263 36
  • 63 (a)
Species with no ortholog for MAT2A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAT2A Gene

Gene Tree for MAT2A (if available)
Gene Tree for MAT2A (if available)

Paralogs for MAT2A Gene

Paralogs for MAT2A Gene

(1) SIMAP similar genes for MAT2A Gene using alignment to 3 proteins: Pseudogenes for MAT2A Gene

genes like me logo Genes that share paralogs with MAT2A: view

Variants for MAT2A Gene

Sequence variations from dbSNP and Humsavar for MAT2A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1078004 -- 85,542,588(-) ATTTT(C/G)CGTCC reference, synonymous-codon
rs1078005 -- 85,542,123(-) CATCA(C/T)ACCAA intron-variant
rs2043675 -- 85,542,852(-) CCATA(C/G/T)ACTTG intron-variant
rs1348817 -- 85,541,595(-) TCCTA(A/G/T)AAATA intron-variant
rs6711750 -- 85,544,174(+) ACTTA(C/T)AGCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MAT2A Gene

Variant ID Type Subtype PubMed ID
nsv2811 CNV Insertion 18451855

Variation tolerance for MAT2A Gene

Residual Variation Intolerance Score: 22.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAT2A Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAT2A Gene

Disorders for MAT2A Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAT2A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acute maxillary sinusitis
  • acute antritis
glycine n-methyltransferase deficiency
  • hypermethioninemia
- elite association - COSMIC cancer census association via MalaCards
Search MAT2A in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAT2A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MAT2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAT2A Gene

Publications for MAT2A Gene

  1. Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. (PMID: 17631143) Chen H. … Lu S.C. (Gastroenterology 2007) 3 23 25 26
  2. Molecular cloning and developmental expression of a human kidney S- adenosylmethionine synthetase. (PMID: 1426236) Horikawa S. … Tsukada K. (FEBS Lett. 1992) 2 3 4 67
  3. Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells. (PMID: 17154373) Yang H. … Lu S.C. (J. Cell. Physiol. 2007) 23 25 26
  4. L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine. (PMID: 12660248) MartA-nez-Chantar M.L. … Avila M.A. (J. Biol. Chem. 2003) 3 23 25
  5. Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma. (PMID: 12671891) Martinez-Chantar M.L. … Mato J.M. (Gastroenterology 2003) 3 23 25

Products for MAT2A Gene

Sources for MAT2A Gene