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Aliases for MAT2A Gene

Aliases for MAT2A Gene

  • Methionine Adenosyltransferase II, Alpha 2 3
  • MATA2 3 4 6
  • Methionine Adenosyltransferase 2 3 4
  • AdoMet Synthase 2 3 4
  • EC 2.5.1.6 4 63
  • MAT-II 3 4
  • MAT 2 3 4
  • SAMS2 3 6
  • S-Adenosylmethionine Synthase Isoform Type-2 3
  • Methionine Adenosyltransferase II 4
  • AdoMet Synthetase 2 3
  • MATII 3
  • AMS2 4

External Ids for MAT2A Gene

Previous GeneCards Identifiers for MAT2A Gene

  • GC02P085661
  • GC02P086060
  • GC02P085740
  • GC02P085677
  • GC02P085619
  • GC02P085766
  • GC02P085663

Summaries for MAT2A Gene

Entrez Gene Summary for MAT2A Gene

  • The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]

GeneCards Summary for MAT2A Gene

MAT2A (Methionine Adenosyltransferase II, Alpha) is a Protein Coding gene. Diseases associated with MAT2A include glycine n-methyltransferase deficiency and hypermethioninemia. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include methionine adenosyltransferase activity. An important paralog of this gene is MAT1A.

UniProtKB/Swiss-Prot for MAT2A Gene

  • Catalyzes the formation of S-adenosylmethionine from methionine and ATP

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAT2A Gene

Genomics for MAT2A Gene

Regulatory Elements for MAT2A Gene

Genomic Location for MAT2A Gene

Start:
85,538,978 bp from pter
End:
85,545,280 bp from pter
Size:
6,303 bases
Orientation:
Plus strand

Genomic View for MAT2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAT2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAT2A Gene

Proteins for MAT2A Gene

  • Protein details for MAT2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31153-METK2_HUMAN
    Recommended name:
    S-adenosylmethionine synthase isoform type-2
    Protein Accession:
    P31153
    Secondary Accessions:
    • A8K511
    • B4DN45
    • D6W5L1
    • Q53SP5

    Protein attributes for MAT2A Gene

    Size:
    395 amino acids
    Molecular mass:
    43661 Da
    Cofactor:
    Name=K(+); Xref=ChEBI:CHEBI:29103; Note=Binds 1 potassium ion per subunit.;
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Note=Binds 2 divalent ions per subunit. Magnesium or cobalt.;
    Quaternary structure:
    • Heterotetramer composed of 2 catalytic alpha subunits (alpha and alpha) (MAT2A) and 1 copy of beta subunit (MAT2B).

    Three dimensional structures from OCA and Proteopedia for MAT2A Gene

    Alternative splice isoforms for MAT2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAT2A Gene

Proteomics data for MAT2A Gene at MOPED

Post-translational modifications for MAT2A Gene

  • The alpha subunit is a post-translationally modified version of MAT2A
  • Ubiquitination at Lys61, Lys81, Lys97, Lys228, Lys234, Lys350, Lys351, and Lys367
  • Modification sites at PhosphoSitePlus

Other Protein References for MAT2A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for MAT2A Gene

Suggested Antigen Peptide Sequences for MAT2A Gene

Graphical View of Domain Structure for InterPro Entry

P31153

UniProtKB/Swiss-Prot:

METK2_HUMAN :
  • P31153
Family:
  • Belongs to the AdoMet synthase family.
genes like me logo Genes that share domains with MAT2A: view

No data available for Gene Families for MAT2A Gene

Function for MAT2A Gene

Molecular function for MAT2A Gene

GENATLAS Biochemistry: methionine adenosyltransferase,extrahepatic isoform,catalytic specific,subunit alpha,expressed in fetal liver,brain,testis,kidney,lymphocytes,sulfur aminoacid metabolism
UniProtKB/Swiss-Prot CatalyticActivity: ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine
UniProtKB/Swiss-Prot Function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP

Enzyme Numbers (IUBMB) for MAT2A Gene

Gene Ontology (GO) - Molecular Function for MAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004478 methionine adenosyltransferase activity IDA 10644686
GO:0005515 protein binding IPI 10644686
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MAT2A: view
genes like me logo Genes that share phenotypes with MAT2A: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MAT2A Gene

Localization for MAT2A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAT2A Gene COMPARTMENTS Subcellular localization image for MAT2A gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0048269 methionine adenosyltransferase complex IDA 10644686
genes like me logo Genes that share ontologies with MAT2A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAT2A Gene

Pathways for MAT2A Gene

genes like me logo Genes that share pathways with MAT2A: view

UniProtKB/Swiss-Prot P31153-METK2_HUMAN

  • Pathway: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1

Gene Ontology (GO) - Biological Process for MAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000096 sulfur amino acid metabolic process --
GO:0006556 S-adenosylmethionine biosynthetic process IEA --
GO:0006730 one-carbon metabolic process IEA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0032259 methylation TAS --
genes like me logo Genes that share ontologies with MAT2A: view

Compounds for MAT2A Gene

(5) HMDB Compounds for MAT2A Gene

Compound Synonyms Cas Number PubMed IDs
Cobalt
  • Co
7440-48-4
L-Methionine
  • (2S)-2-amino-4-(methylsulfanyl)butanoic acid
63-68-3
Magnesium
  • Magnesium
7439-95-4
Potassium
  • K+
7440-09-7
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0

(2) Drugbank Compounds for MAT2A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Methionine
  • (S)-2-amino-4-(methylthio)butanoic acid
63-68-3 enzyme substrate
S-Adenosylmethionine
  • Acylcarnitine
29908-03-0 target cofactor

(3) Novoseek inferred chemical compound relationships for MAT2A Gene

Compound -log(P) Hits PubMed IDs
s-adenosylmethionine 89.3 45
methionine 84 34
5-methylthioadenosine 79.4 7
genes like me logo Genes that share compounds with MAT2A: view

Transcripts for MAT2A Gene

Unigene Clusters for MAT2A Gene

Methionine adenosyltransferase II, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAT2A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1: - - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: -
SP6:
SP7:
SP8: -

Relevant External Links for MAT2A Gene

GeneLoc Exon Structure for
MAT2A
ECgene alternative splicing isoforms for
MAT2A

Expression for MAT2A Gene

mRNA expression in normal human tissues for MAT2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAT2A Gene

SOURCE GeneReport for Unigene cluster for MAT2A Gene Hs.516157

genes like me logo Genes that share expressions with MAT2A: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MAT2A Gene

Orthologs for MAT2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAT2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAT2A 35
  • 99.49 (n)
  • 100 (a)
MAT2A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAT2A 35
  • 94.6 (n)
  • 99.24 (a)
MAT2A 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAT2A 35
  • 95.02 (n)
  • 99.75 (a)
MAT2A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mat2a 35
  • 93.16 (n)
  • 99.49 (a)
Mat2a 16
Mat2a 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAT2A 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAT2A 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mat2a 35
  • 93.5 (n)
  • 98.48 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 72 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia MAT2A 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia m(2)21ab-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mat2a 35
  • 79.92 (n)
  • 92.91 (a)
MGC76253 35
zebrafish
(Danio rerio)
Actinopterygii mat2aa 36
  • 92 (a)
OneToMany
mat2ab 35
  • 75.51 (n)
  • 90.06 (a)
mat2ab 36
  • 90 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009447 35
  • 65.56 (n)
  • 74.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sam-S 35
  • 67.71 (n)
  • 74.61 (a)
Sam-S 36
  • 69 (a)
OneToMany
M(2)21AB 37
  • 74 (a)
worm
(Caenorhabditis elegans)
Secernentea sams-1 36
  • 63 (a)
ManyToMany
sams-3 35
  • 66.67 (n)
  • 74.27 (a)
sams-3 36
  • 69 (a)
ManyToMany
sams-4 36
  • 68 (a)
ManyToMany
sams-5 36
  • 67 (a)
ManyToMany
C06E7.1a 37
  • 74 (a)
C49F5.1 37
  • 67 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR692C 35
  • 60.67 (n)
  • 67.72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAM1 35
  • 63.51 (n)
  • 68.16 (a)
SAM1 36
  • 67 (a)
ManyToMany
SAM2 36
  • 66 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C01782g 35
  • 64.46 (n)
  • 68.25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MAT3 35
  • 63.23 (n)
  • 66.93 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02657 35
  • 64.79 (n)
  • 69.74 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sam1 35
  • 65.26 (n)
  • 69.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10263 36
  • 63 (a)
OneToMany
Species with no ortholog for MAT2A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAT2A Gene

ENSEMBL:
Gene Tree for MAT2A (if available)
TreeFam:
Gene Tree for MAT2A (if available)

Paralogs for MAT2A Gene

Paralogs for MAT2A Gene

Selected SIMAP similar genes for MAT2A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for MAT2A Gene

genes like me logo Genes that share paralogs with MAT2A: view

Variants for MAT2A Gene

Sequence variations from dbSNP and Humsavar for MAT2A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1078004 -- 85,542,588(-) ATTTT(C/G)CGTCC reference, synonymous-codon
rs1078005 -- 85,542,123(-) CATCA(C/T)ACCAA intron-variant
rs1348817 -- 85,541,595(-) TCCTA(A/G/T)AAATA intron-variant
rs2043675 -- 85,542,852(-) CCATA(C/T)ACTTG intron-variant
rs6711750 -- 85,544,174(+) ACTTA(C/T)AGCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MAT2A Gene

Variant ID Type Subtype PubMed ID
nsv2811 CNV Insertion 18451855

Relevant External Links for MAT2A Gene

HapMap Linkage Disequilibrium report
MAT2A
Human Gene Mutation Database (HGMD)
MAT2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAT2A Gene

Disorders for MAT2A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MAT2A Gene including...

Search for MAT2A Gene in MalaCards »

(2) University of Copenhagen DISEASES for MAT2A Gene

(3) Novoseek inferred disease relationships for MAT2A Gene

Disease -log(P) Hits PubMed IDs
hepatocellular carcinoma 52.1 6
tumors 0 3
cancer 0 7

Relevant External Links for MAT2A

Genetic Association Database (GAD)
MAT2A
Human Genome Epidemiology (HuGE) Navigator
MAT2A
genes like me logo Genes that share disorders with MAT2A: view

No data available for UniProtKB/Swiss-Prot for MAT2A Gene

Publications for MAT2A Gene

  1. Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II). (PMID: 10644686) LeGros H.L. … Kotb M. (J. Biol. Chem. 2000) 3 4 23
  2. Cloning and functional characterization of the 5'-flanking region of human methionine adenosyltransferase 2A gene. (PMID: 9703951) Mao Z. … Lu S.C. (Biochem. Biophys. Res. Commun. 1998) 2 3 23
  3. Molecular cloning and developmental expression of a human kidney S- adenosylmethionine synthetase. (PMID: 1426236) Horikawa S. … Tsukada K. (FEBS Lett. 1992) 2 3 4
  4. Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. (PMID: 17631143) Chen H. … Lu S.C. (Gastroenterology 2007) 3 23 25
  5. L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine. (PMID: 12660248) MartA-nez-Chantar M.L. … Avila M.A. (J. Biol. Chem. 2003) 3 23 25

Products for MAT2A Gene

Sources for MAT2A Gene

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