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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAT2A Gene

protein-coding   GIFtS: 67
GCID: GC02P085766

Methionine Adenosyltransferase II, Alpha

Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Methionine Adenosyltransferase II, Alpha1 2     SAMS22 5
MATA22 3 5     MATII2
AdoMet Synthase 22 3     AdoMet Synthetase 22
Methionine Adenosyltransferase 22 3     S-Adenosylmethionine Synthase Isoform Type-22
MAT-II2 3     AMS23
MAT 22 3     Methionine Adenosyltransferase II3
EC 2.5.1.63 8     

External Ids:    HGNC: 69041   Entrez Gene: 41442   Ensembl: ENSG000001689067   OMIM: 6014685   UniProtKB: P311533   

Export aliases for MAT2A gene to outside databases

Previous GC identifers: GC02P085661 GC02P086060 GC02P085740 GC02P085677 GC02P085619 GC02P085663


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAT2A Gene:
The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and
ATP. AdoMet is the key methyl donor in cellular processes. (provided by RefSeq, Jun 2011)

GeneCards Summary for MAT2A Gene: 
MAT2A (methionine adenosyltransferase II, alpha) is a protein-coding gene. Diseases associated with MAT2A include glycine n-methyltransferase deficiency, and hypermethioninemia, and among its related super-pathways are Cysteine and methionine metabolism and methionine degradation I (to homocysteine). GO annotations related to this gene include methionine adenosyltransferase activity and metal ion binding. An important paralog of this gene is MAT1A.

UniProtKB/Swiss-Prot: METK2_HUMAN, P31153
Function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAT2A gene promoter:
         GR   Sox5   GR-beta   RelA   Evi-1   AREB6   PPAR-alpha   PPAR-gamma1   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAT2A promoter sequence
   Search SABiosciences Chromatin IP Primers for MAT2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAT2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

MAT2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAT2A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P085766:  view genomic region     (about GC identifiers)

Start:
85,766,101 bp from pter      End:
85,772,403 bp from pter
Size:
6,303 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: METK2_HUMAN, P31153 (See protein sequence)
Recommended Name: S-adenosylmethionine synthase isoform type-2  
Size: 395 amino acids; 43661 Da
Cofactor: Binds 2 divalent ions per subunit. Magnesium or cobalt (By similarity)
Cofactor: Binds 1 potassium ion per subunit (By similarity)
Subunit: Heterotetramer composed of 2 catalytic alpha subunits (alpha and alpha') (MAT2A) and 1 copy of beta
subunit (MAT2B)
1 PDB 3D structure from and Proteopedia for MAT2A:
2P02 (3D)    
Secondary accessions: A8K511 D6W5L1 Q53SP5

Explore the universe of human proteins at neXtProt for MAT2A: NX_P31153

Explore proteomics data for MAT2A at MOPED 

Post-translational modifications:

  • UniProtKB: The alpha' subunit is a post-translationally modified version of MAT2A
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P31153

  • 4/34 DME Specific Peptides for MAT2A (P31153) (see all 34)
     TKVDRSA  IGAGDQG  DYQKVVR  PLSISIF 

    MAT2A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAT2A Protein Expression
    REFSEQ proteins: NP_005902.1  
    ENSEMBL proteins: 
     ENSP00000303147   ENSP00000386353  
    Reactome Protein details: P31153
    Human Recombinant Protein Products for MAT2A: 
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    Novus Biologicals MAT2A Proteins
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MAT2A
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    MAT2A for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR022636 S-AdoMet_synthetase_sfam
     IPR022628 S-AdoMet_synt_N
     IPR022631 ADOMET_SYNTHASE_CS
     IPR022630 S-AdoMet_synt_C
     IPR002133 S-AdoMet_synthetase

    Graphical View of Domain Structure for InterPro Entry P31153

    ProtoNet protein and cluster: P31153

    1 Blocks protein domain: IPB002133 S-adenosylmethionine synthetase

    UniProtKB/Swiss-Prot: METK2_HUMAN, P31153
    Similarity: Belongs to the AdoMet synthase family


    MAT2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: METK2_HUMAN, P31153
    Function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP
    Catalytic activity: ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine

         Genatlas biochemistry entry for MAT2A:
    methionine adenosyltransferase,extrahepatic isoform,catalytic specific,subunit alpha,expressed in fetal
    liver,brain,testis,kidney,lymphocytes,sulfur aminoacid metabolism

         Enzyme Number (IUBMB): EC 2.5.1.61 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004478methionine adenosyltransferase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0046872metal ion binding IEA--
         
    MAT2A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MAT2A:
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mat2a):
     behavior/neurological  nervous system 

    MAT2A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAT2A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAT2A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAT2A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAT2A 

    miRNA
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    miRTarBase miRNAs that target MAT2A:
    hsa-mir-30a (MIRT005213)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAT2A
    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate MAT2A (see all 50):
    hsa-miR-21* hsa-miR-3164 hsa-miR-122* hsa-miR-1197 hsa-miR-631 hsa-miR-488 hsa-miR-30d hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidMAT2A 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAT2A About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cysteine and methionine metabolism
    Cysteine and methionine metabolism0.37
    Methionine metabolism0.32
    Sulfur amino acid metabolism0.37
    2methionine degradation I (to homocysteine)
    methionine degradation I (to homocysteine)0.83
    S-adenosyl-L-methionine biosynthesis0.60
    cysteine biosynthesis III (mammalia)0.83
    Methylation0.30
    3Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    4Biological oxidations
    Biological oxidations0.55
    Phase II conjugation0.55
    5Carbon metabolism
    Biosynthesis of amino acids0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MAT2A
        Methionine metabolism


    1 GeneGo (Thomson Reuters) Pathway for MAT2A
        Methionine metabolism

    5 BioSystems Pathways for MAT2A
        C-MYB transcription factor network
    S-adenosyl-L-methionine biosynthesis
    methionine degradation I (to homocysteine)
    superpathway of methionine degradation
    cysteine biosynthesis III (mammalia)


    5/6        Reactome Pathways for MAT2A (see all 6)
        Metabolism
    Sulfur amino acid metabolism
    Biological oxidations
    Metabolism of amino acids and derivatives
    Phase II conjugation


    3         Kegg Pathways  (Kegg details for MAT2A):
        Cysteine and methionine metabolism
    Metabolic pathways
    Biosynthesis of amino acids

    UniProtKB/Swiss-Prot: METK2_HUMAN, P31153
    Pathway: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine:
    step 1/1


    MAT2A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAT2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/94 Interacting proteins for MAT2A (P311533 ENSP000003031474) via UniProtKB, MINT, STRING, and/or I2D (see all 94)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=1 STRING: ENSP00000363970
    SAP18O004223, ENSP000003719734I2D: score=1 STRING: ENSP00000371973
    MAT2BQ9NZL93, ENSP000003254254I2D: score=2 STRING: ENSP00000325425
    HGSO149643, ENSP000003312014I2D: score=1 STRING: ENSP00000331201
    ACTR6Q9GZN13, ENSP000001883124I2D: score=1 STRING: ENSP00000188312
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0006556S-adenosylmethionine biosynthetic process IEA--
    GO:0006730one-carbon metabolic process IEA--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0032259methylation TAS--

    MAT2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAT2A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAT2A (METK2)

    5 HMDB Compounds for MAT2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CobaltCo (see all 6)7440-48-4--
    L-Methionine(2S)-2-amino-4-(methylsulfanyl)butanoic acid (see all 54)63-68-3--
    MagnesiumMagnesium (see all 2)7439-95-4--
    PotassiumK+ (see all 16)7440-09-7--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    2 DrugBank Compounds for MAT2A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Methionine(S)-2-amino-4-(methylthio)butanoic acid (see all 6)63-68-3enzymesubstrate17154373 17317269 17631143 16482628
    S-AdenosylmethionineAcylcarnitine (see all 6)29908-03-0targetcofactor12023972 12671891 12660248 11596649

    3 Novoseek inferred chemical compound relationships for MAT2A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    s-adenosylmethionine 89.3 77 17869084 (6), 17631143 (5), 18041713 (3), 19048023 (3) (see all 23)
    methionine 84 53 12660248 (8), 19048023 (2), 17869084 (2), 9188509 (2) (see all 21)
    5-methylthioadenosine 79.4 11 17631143 (4), 18041713 (2), 12660248 (1)

    Search CenterWatch for drugs/clinical trials and news about MAT2A / METK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAT2A gene: 
    NM_005911.5  

    Unigene Cluster for MAT2A:

    Methionine adenosyltransferase II, alpha
    Hs.516157  [show with all ESTs]
    Unigene Representative Sequence: NM_005911
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306434(uc002spr.3) ENST00000465151 ENST00000469221 ENST00000481412(uc010fgm.1)
    ENST00000409017(uc010ysr.2 uc010fgl.2) ENST00000490878
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate MAT2A (see all 50):
    hsa-miR-21* hsa-miR-3164 hsa-miR-122* hsa-miR-1197 hsa-miR-631 hsa-miR-488 hsa-miR-30d hsa-miR-29b-1*
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAT2A

    Additional mRNA sequence: 

    AK291126.1 AK293841.1 AK294208.1 AK297758.1 AK297797.1 AK303877.1 AK308591.1 AK308758.1 
    AK309338.1 AK311142.1 AK311612.1 AK316411.1 BC001686.2 BC001854.2 DQ083239.1 X68836.1 

    24/45 DOTS entries (see all 45):

    DT.40295726  DT.85101185  DT.97862448  DT.75171568  DT.85101167  DT.100878478  DT.95375821  DT.97862445 
    DT.100031631  DT.121022881  DT.95139354  DT.121023010  DT.120865169  DT.100878485  DT.91842399  DT.121022873 
    DT.95375815  DT.121022946  DT.121022885  DT.121022889  DT.75147741  DT.95375824  DT.100878459  DT.120865165 

    24/828 AceView cDNA sequences (see all 828):

    BM760872 BM765941 N53625 AU131996 AA988381 BM784201 AI282528 CB043961 
    CA434772 CB133891 X68836 BP350460 AW083602 AU131292 AA704797 CB152957 
    AA703212 BM766133 AL041029 AU129982 BE312793 AW473222 BE327005 BM789319 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MAT2A (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
    SP1:                                -     -           -                 -                             -         
    SP2:                                -     -           -                                                         
    SP3:                                -     -                                                                     
    SP4:                                -     -                             -                                       
    SP5:                                                                    -                                       


    ECgene alternative splicing isoforms for MAT2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAT2A expression in normal human tissues (normalized intensities)      MAT2A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGCTTGCC
    MAT2A Expression
    About this image


    MAT2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus

    See MAT2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAT2A

    SOURCE GeneReport for Unigene cluster: Hs.516157
        SABiosciences Expression via Pathway-Focused PCR Array including MAT2A: 
              Circadian Rhythms in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAT2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAT2A gene from 9/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mat2a1 , 5 methionine adenosyltransferase II, alpha1, 5 93.16(n)1
    99.49(a)1
      6 (32.27 cM)5
    2320871  NM_145569.41  NP_663544.11 
     724327995 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    73(a)
    possible ortholog
    Z(53262872-53287724)
    lizard
    (Anolis carolinensis)
    Reptilia MAT2A6
    S-adenosylmethionine synthase
    90(a)
    1 ↔ 1
    GL343545.1(383347-397095)
    African clawed frog
    (Xenopus laevis)
    Amphibia m(2)21ab-prov2 methionine adenosyltransferase II 79.12(n)    BC043970.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mat2ab1 methionine adenosyltransferase II, alpha b 75.51(n)
    90.06(a)
      791612  NM_001014296.1  NP_001014318.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta M(2)21AB3
    Sam-S1
    S-adenosylmethionine biosynthesis
    methionine adenosyltransferase3
    S-adenosylmethionine Synthetase1
    74(a)3
    67.36(n)1
    74.87(a)1
      485521  NM_205880.11  NP_995602.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C06E7.1a3
    sams-31
    S-adenosylmethionine synthetase3
    Protein SAMS-31
    74(a)
    (best of 2)3
    66.67(n)1
    74.27(a)1
      IV(5848877-5850786)3
    1773551  NM_068471.41  NP_500872.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SAM11 Sam1p 63.51(n)
    68.16(a)
      850877   NP_013281.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MAT31 S-adenosylmethionine synthase 3 63.23(n)
    66.93(a)
      818260  NM_129243.3  NP_181225.1 


    ENSEMBL Gene Tree for MAT2A (if available)
    TreeFam Gene Tree for MAT2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAT2A gene
    MAT1A2  
    1 SIMAP similar gene for MAT2A using alignment to 3 protein entries:     METK2_HUMAN (see all proteins):
    MAT1A

    MAT2A for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MAT2A
    PGOHUM00000239890 PGOHUM00000237723


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/213 SNPs in MAT2A are shown (see all 213)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1504074251,2
    --85628200(+) TATCCC/TGACAG 1 -- us2k10--------
    rs1153204981,2
    C,F--85628264(+) AGCTTA/CCATTA 1 -- us2k12Minor allele frequency- C:0.01WA 694
    rs1143423561,2
    C,F--85628296(+) CTGTGC/TTAAAG 1 -- us2k12Minor allele frequency- T:0.01WA 694
    rs1896621721,2
    --85628301(+) CTAAAA/GACTCT 1 -- us2k10--------
    rs1822988921,2
    --85628337(+) CAATCC/TTATGA 1 -- us2k10--------
    rs130200281,2
    C,F--85628525(+) GTTGGT/CAGCAC 1 -- us2k13Minor allele frequency- C:0.02NA 580
    rs729405561,2
    C,F--85628596(+) ATAAAA/TTAACC 1 -- us2k13Minor allele frequency- T:0.05WA 696
    rs1141795781,2
    C,F--85628672(+) CACACG/ACATTT 1 -- us2k12Minor allele frequency- A:0.01NA 696
    rs751919711,2
    C,F--85628785(+) ATGAAG/AGGTTA 1 -- us2k12Minor allele frequency- A:0.01WA 694
    rs1854634381,2
    --85628829(+) CATCAC/TCTATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAT2A (85766101 - 85772403 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MAT2A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2811CNV Insertion18451855

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601468    OMIM disorders: --

    14 diseases for MAT2A:    About MalaCards
    glycine n-methyltransferase deficiency    hypermethioninemia    ependymoma    spina bifida
    hepatocellular carcinoma    pneumonia    alcoholism    colon cancer
    tuberculosis    hepatitis b    hypoxia    colorectal cancer
    hepatitis    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for MAT2A:
    Hypermethioninemia     Hepatocellular carcinoma

    MAT2A for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for MAT2A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 52.1 6 11208539 (1), 11427482 (1), 17154373 (1), 14530285 (1) (see all 6)
    tumors 0 6 14530285 (1), 18045590 (1), 14578171 (1)
    cancer 0 8 11208539 (1), 11427482 (1), 14530285 (1), 18095270 (1) (see all 7)

    Genetic Association Database (GAD): MAT2A
    Human Genome Epidemiology (HuGE) Navigator: MAT2A (10 documents)

    Export disorders for MAT2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAT2A gene, integrated from 9 sources (see all 87):
    (articles sorted by number of sources associating them with MAT2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and developmental expression of a human kidney S- adenosylmethionine synthetase. (PubMed id 1426236)1, 2, 3 Horikawa S. and Tsukada K. (1992)
    2. Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. (PubMed id 17631143)1, 7, 9 Chen H....Lu S.C. (2007)
    3. L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine. (PubMed id 12660248)1, 7, 9 Martinez-Chantar M.L....Avila M.A. (2003)
    4. Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma. (PubMed id 12671891)1, 7, 9 Martinez-Chantar M.L.... Mato J.M. (2003)
    5. Cloning and functional characterization of the 5'-fla nking region of human methionine adenosyltransferase 2A gene. (PubMed id 9703951)1, 3, 9 Mao Z....Lu S.C. (1998)
    6. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    7. A candidate gene study of folate-associated one carbo n metabolism genes and colorectal cancer risk. (PubMed id 20615890)1, 4 Levine A.J....Haile R.W. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Genetic association study of putative functional sing le nucleotide polymorphisms of genes in folate metabolism and spina bifida. (PubMed id 19683694)1, 4 Martinez C.A....Au K.S. (2009)
    10. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PubMed id 19161160)1, 4 Franke B....Blom H.J. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4144 HGNC: 6904 AceView: MAT2A Ensembl:ENSG00000168906 euGenes: HUgn4144
    ECgene: MAT2A Kegg: 4144 H-InvDB: MAT2A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAT2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAT2A gene:
    Search GeneIP for patents involving MAT2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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