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Aliases for MAT2A Gene

Aliases for MAT2A Gene

  • Methionine Adenosyltransferase 2A 2 3 5
  • Methionine Adenosyltransferase II, Alpha 2 3
  • Methionine Adenosyltransferase 2 3 4
  • AdoMet Synthase 2 3 4
  • EC 2.5.1.6 4 61
  • MAT-II 3 4
  • MAT 2 3 4
  • MATA2 3 4
  • S-Adenosylmethionine Synthase Isoform Type-2 3
  • Methionine Adenosyltransferase II 4
  • Testicular Tissue Protein Li 121 3
  • AdoMet Synthetase 2 3
  • MATII 3
  • SAMS2 3
  • AMS2 4

External Ids for MAT2A Gene

Previous GeneCards Identifiers for MAT2A Gene

  • GC02P085661
  • GC02P086060
  • GC02P085740
  • GC02P085677
  • GC02P085619
  • GC02P085766
  • GC02P085663

Summaries for MAT2A Gene

Entrez Gene Summary for MAT2A Gene

  • The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]

GeneCards Summary for MAT2A Gene

MAT2A (Methionine Adenosyltransferase 2A) is a Protein Coding gene. Diseases associated with MAT2A include Acute Maxillary Sinusitis and Glycine N-Methyltransferase Deficiency. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include methionine adenosyltransferase activity. An important paralog of this gene is MAT1A.

UniProtKB/Swiss-Prot for MAT2A Gene

  • Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAT2A Gene

Genomics for MAT2A Gene

Regulatory Elements for MAT2A Gene

Enhancers for MAT2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F085497 1 FANTOM5 Ensembl ENCODE 18.9 -36.2 -36204 10.5 HDGF ARNT MLX ARID4B SIN3A DMAP1 YY1 ZNF143 FOS KLF13 USP39 TMEM150A TCF7L1 MAT2A SNORD94 LOC100996506 RN7SL251P RNU7-64P CAPG C2orf68
GH02F086371 0.5 Ensembl 18.1 +833.0 833023 1.2 ZFP64 ZNF138 GATA2 FOS ZNF202 ZNF680 ZNF654 ZBTB11 REST ZNF623 SNORD94 LOC102724642 LOC105374845 ENSG00000231259 LOC100420889 CHMP3 MAT2A C2orf68 ENSG00000202537 REEP1
GH02F085432 1.3 FANTOM5 ENCODE 12 -102.6 -102568 7.7 SIN3A ELK1 ZNF207 FOS KLF13 ZNF263 SP3 JUNB REST MAFF SH2D6 MAT2A CAPG TGOLN2 KCMF1 ENSG00000207207 RNU7-64P
GH02F085516 0.8 Ensembl ENCODE 11.7 -21.9 -21885 1.8 ELF3 ZFP64 RAD21 RARA KAT2B ZNF23 FOS EGR2 THAP11 GLIS1 GGCX RN7SL251P RNU7-64P MAT2A ELMOD3 RETSAT GC02M085532 RPSAP22
GH02F085563 0.6 Ensembl ENCODE 11.6 +25.2 25223 1.2 ATF1 NFRKB PTRF IRF9 STAT2 PRDM10 TRIM24 CREM STAT1 RNF2 VAMP5 C2orf68 TMEM150A USP39 MAT2A CAPG SH2D6 ELMOD3 RETSAT VAMP8
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MAT2A on UCSC Golden Path with GeneCards custom track

Promoters for MAT2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000676786 522 4201 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for MAT2A Gene

Chromosome:
2
Start:
85,538,978 bp from pter
End:
85,545,280 bp from pter
Size:
6,303 bases
Orientation:
Plus strand

Genomic View for MAT2A Gene

Genes around MAT2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAT2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAT2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAT2A Gene

Proteins for MAT2A Gene

  • Protein details for MAT2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31153-METK2_HUMAN
    Recommended name:
    S-adenosylmethionine synthase isoform type-2
    Protein Accession:
    P31153
    Secondary Accessions:
    • A8K511
    • B4DN45
    • D6W5L1
    • Q53SP5

    Protein attributes for MAT2A Gene

    Size:
    395 amino acids
    Molecular mass:
    43661 Da
    Cofactor:
    Name=K(+); Xref=ChEBI:CHEBI:29103;
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain (PubMed:10644686, PubMed:23189196). Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain (PubMed:25075345).

    Three dimensional structures from OCA and Proteopedia for MAT2A Gene

    Alternative splice isoforms for MAT2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAT2A Gene

Selected DME Specific Peptides for MAT2A Gene

P31153:
  • GHPDKICD
  • AKVACETV
  • TGRKIIVDTYGG
  • IGAGDQG
  • PLSISIF
  • HGGGAFSGKD
  • FVIGGPQGD
  • AAYGHFGR
  • GRFVIGGP
  • DLDLKKPIY
  • LPWLRPD
  • QVSYAIG
  • GAGDQGLMFGYA
  • HIGYDDS
  • PIRVHTIVISVQHDEEVCLDEMRDALKEK
  • GLTGRKI
  • SYAIGVSHPLS
  • KGFDYKTCNVLVA
  • LFTSESV
  • QSPDIAQG
  • KTQVTVQY
  • VHLDRNEED
  • FTSESVGEGHPDK
  • DQISDAVLD
  • TKVDRSA
  • DYQKVVR
  • PAKYLDE
  • KTCNVLVALEQQSP
  • SDAVLDA
  • NFDLRPGVIV
  • MFGYATDET
  • LCRRVLVQVSY
  • CDQISDA
  • KVDRSAAY

Post-translational modifications for MAT2A Gene

  • Ubiquitination at Lys 61, Lys 81, Lys 97, Lys 228, Lys 234, Lys 350, and Lys 367
  • Modification sites at PhosphoSitePlus

Other Protein References for MAT2A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MAT2A Gene

Suggested Antigen Peptide Sequences for MAT2A Gene

Graphical View of Domain Structure for InterPro Entry

P31153

UniProtKB/Swiss-Prot:

METK2_HUMAN :
  • Belongs to the AdoMet synthase family.
Family:
  • Belongs to the AdoMet synthase family.
genes like me logo Genes that share domains with MAT2A: view

No data available for Gene Families for MAT2A Gene

Function for MAT2A Gene

Molecular function for MAT2A Gene

GENATLAS Biochemistry:
methionine adenosyltransferase,extrahepatic isoform,catalytic specific,subunit alpha,expressed in fetal liver,brain,testis,kidney,lymphocytes,sulfur aminoacid metabolism
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine.
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.

Enzyme Numbers (IUBMB) for MAT2A Gene

Gene Ontology (GO) - Molecular Function for MAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004478 methionine adenosyltransferase activity IDA 7665609
GO:0005515 protein binding IPI 10644686
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with MAT2A: view
genes like me logo Genes that share phenotypes with MAT2A: view

Animal Models for MAT2A Gene

MGI Knock Outs for MAT2A:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAT2A

miRNA for MAT2A Gene

miRTarBase miRNAs that target MAT2A

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAT2A Gene

Localization for MAT2A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAT2A Gene COMPARTMENTS Subcellular localization image for MAT2A gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0048269 methionine adenosyltransferase complex IDA 10644686
genes like me logo Genes that share ontologies with MAT2A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAT2A Gene

Pathways & Interactions for MAT2A Gene

genes like me logo Genes that share pathways with MAT2A: view

Pathways by source for MAT2A Gene

UniProtKB/Swiss-Prot P31153-METK2_HUMAN

  • Pathway: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.

Gene Ontology (GO) - Biological Process for MAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006556 S-adenosylmethionine biosynthetic process IEA,IDA --
GO:0006730 one-carbon metabolic process IEA --
GO:0032259 methylation TAS --
GO:0034214 protein hexamerization IDA 25075345
GO:0051291 protein heterooligomerization IDA 25075345
genes like me logo Genes that share ontologies with MAT2A: view

No data available for SIGNOR curated interactions for MAT2A Gene

Drugs & Compounds for MAT2A Gene

(9) Drugs for MAT2A Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra Target, cofactor 0
L-Methionine Approved Nutra Enzyme, substrate 0
Phosphoric acid Approved Pharma 0
Potassium Approved Pharma 0
Water Approved Pharma 0

(4) Additional Compounds for MAT2A Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
Se-Adenosylselenomethionine
selenomethionine
  • (+-)-Selenomethionine
  • (2S)-2-amino-4-(methylseleno)butanoate
  • (2S)-2-amino-4-(methylseleno)butanoic acid
  • (S)-2-amino-4-(methylseleno)-Butanoate
  • (S)-2-amino-4-(methylseleno)-Butanoic acid
3211-76-5
genes like me logo Genes that share compounds with MAT2A: view

Transcripts for MAT2A Gene

Unigene Clusters for MAT2A Gene

Methionine adenosyltransferase II, alpha:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAT2A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1: - - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: -
SP6:
SP7:
SP8: -

Relevant External Links for MAT2A Gene

GeneLoc Exon Structure for
MAT2A
ECgene alternative splicing isoforms for
MAT2A

Expression for MAT2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAT2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAT2A Gene



Protein tissue co-expression partners for MAT2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAT2A Gene:

MAT2A

SOURCE GeneReport for Unigene cluster for MAT2A Gene:

Hs.516157

mRNA Expression by UniProt/SwissProt for MAT2A Gene:

P31153-METK2_HUMAN
Tissue specificity: Detected in kidney.
genes like me logo Genes that share expression patterns with MAT2A: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for MAT2A Gene

Orthologs for MAT2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAT2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAT2A 34 35
  • 99.49 (n)
oppossum
(Monodelphis domestica)
Mammalia MAT2A 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAT2A 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAT2A 34 35
  • 95.02 (n)
cow
(Bos Taurus)
Mammalia MAT2A 34 35
  • 94.6 (n)
rat
(Rattus norvegicus)
Mammalia Mat2a 34
  • 93.5 (n)
mouse
(Mus musculus)
Mammalia Mat2a 34 16 35
  • 93.16 (n)
chicken
(Gallus gallus)
Aves -- 35
  • 72 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia MAT2A 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mat2a 34
  • 79.92 (n)
MGC76253 34
African clawed frog
(Xenopus laevis)
Amphibia m(2)21ab-prov 34
zebrafish
(Danio rerio)
Actinopterygii mat2aa 35
  • 92 (a)
OneToMany
mat2ab 34 35
  • 75.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta M(2)21AB 36
  • 74 (a)
Sam-S 34 35
  • 67.71 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009447 34
  • 65.56 (n)
worm
(Caenorhabditis elegans)
Secernentea C06E7.1a 36
  • 74 (a)
sams-4 35
  • 68 (a)
ManyToMany
C49F5.1 36
  • 67 (a)
sams-5 35
  • 67 (a)
ManyToMany
sams-3 34 35
  • 66.67 (n)
sams-1 35
  • 63 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAM2 35
  • 66 (a)
ManyToMany
SAM1 34 35
  • 63.51 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C01782g 34
  • 64.46 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR692C 34
  • 60.67 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MAT3 34
  • 63.23 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sam1 34
  • 65.26 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02657 34
  • 64.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10263 35
  • 63 (a)
OneToMany
Species where no ortholog for MAT2A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAT2A Gene

ENSEMBL:
Gene Tree for MAT2A (if available)
TreeFam:
Gene Tree for MAT2A (if available)

Paralogs for MAT2A Gene

Paralogs for MAT2A Gene

(1) SIMAP similar genes for MAT2A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for MAT2A Gene

genes like me logo Genes that share paralogs with MAT2A: view

Variants for MAT2A Gene

Sequence variations from dbSNP and Humsavar for MAT2A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1048739 -- 85,537,845(-) TGCCT(A/C)CTGCT nc-transcript-variant, upstream-variant-2KB
rs1048740 -- 85,537,843(-) CCTAC(A/T)GCTGG nc-transcript-variant, upstream-variant-2KB
rs1050108 -- 85,544,616(+) ACAGG(G/T)CAGTA downstream-variant-500B, utr-variant-3-prime
rs1063503 -- 85,545,075(+) AGGGC(A/G)GAGCT utr-variant-3-prime
rs1078004 -- 85,542,588(-) ATTTT(C/G)CGTCC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MAT2A Gene

Variant ID Type Subtype PubMed ID
nsv2811 CNV insertion 18451855
nsv961801 CNV duplication 23825009

Variation tolerance for MAT2A Gene

Residual Variation Intolerance Score: 22.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAT2A Gene

Human Gene Mutation Database (HGMD)
MAT2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAT2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAT2A Gene

Disorders for MAT2A Gene

MalaCards: The human disease database

(3) MalaCards diseases for MAT2A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acute maxillary sinusitis
  • acute antritis
glycine n-methyltransferase deficiency
  • hypermethioninemia
hypermethioninemia with deficiency of s-adenosylhomocysteine hydrolase
  • hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency
- elite association - COSMIC cancer census association via MalaCards
Search MAT2A in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAT2A

Genetic Association Database (GAD)
MAT2A
Human Genome Epidemiology (HuGE) Navigator
MAT2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAT2A
genes like me logo Genes that share disorders with MAT2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAT2A Gene

Publications for MAT2A Gene

  1. Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. (PMID: 17631143) Chen H. … Lu S.C. (Gastroenterology 2007) 3 22 25 64
  2. Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II). (PMID: 10644686) LeGros H.L. … Kotb M. (J. Biol. Chem. 2000) 3 4 22 64
  3. Cloning and functional characterization of the 5'-flanking region of human methionine adenosyltransferase 2A gene. (PMID: 9703951) Mao Z. … Lu S.C. (Biochem. Biophys. Res. Commun. 1998) 2 3 22 64
  4. Molecular cloning and developmental expression of a human kidney S- adenosylmethionine synthetase. (PMID: 1426236) Horikawa S. … Tsukada K. (FEBS Lett. 1992) 2 3 4 64
  5. Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes. (PMID: 26858410) Murray B. … Rojas A.L. (Proc. Natl. Acad. Sci. U.S.A. 2016) 3 4 64

Products for MAT2A Gene

  • Cloud-Clone Corp. Antibodies for MAT2A
  • Cloud-Clone Corp. Proteins for MAT2A
  • Cloud-Clone Corp Assay Kits for MAT2A

Sources for MAT2A Gene

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