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MAT2A Gene

protein-coding   GIFtS: 68
GCID: GC02P085766

Methionine Adenosyltransferase II, Alpha

  See MAT2A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Methionine Adenosyltransferase II, Alpha1 2     SAMS22 5
MATA22 3 5     MATII2
AdoMet Synthase 22 3     AdoMet Synthetase 22
Methionine Adenosyltransferase 22 3     S-Adenosylmethionine Synthase Isoform Type-22
MAT-II2 3     AMS23
MAT 22 3     Methionine Adenosyltransferase II3
EC 2.5.1.63 8     

External Ids:    HGNC: 69041   Entrez Gene: 41442   Ensembl: ENSG000001689067   OMIM: 6014685   UniProtKB: P311533   

Export aliases for MAT2A gene to outside databases

Previous GC identifers: GC02P085661 GC02P086060 GC02P085740 GC02P085677 GC02P085619 GC02P085663


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAT2A Gene:
The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and
ATP. AdoMet is the key methyl donor in cellular processes. (provided by RefSeq, Jun 2011)

GeneCards Summary for MAT2A Gene:
MAT2A (methionine adenosyltransferase II, alpha) is a protein-coding gene. Diseases associated with MAT2A include glycine n-methyltransferase deficiency, and hypermethioninemia. GO annotations related to this gene include methionine adenosyltransferase activity. An important paralog of this gene is MAT1A.

UniProtKB/Swiss-Prot: METK2_HUMAN, P31153
Function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAT2A gene promoter:
         GR   Sox5   GR-beta   RelA   Evi-1   AREB6   PPAR-alpha   PPAR-gamma1   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAT2A promoter sequence
   Search Chromatin IP Primers for MAT2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAT2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

MAT2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAT2A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P085766:  view genomic region     (about GC identifiers)

Start:
85,766,101 bp from pter      End:
85,772,403 bp from pter
Size:
6,303 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: METK2_HUMAN, P31153 (See protein sequence)
Recommended Name: S-adenosylmethionine synthase isoform type-2  
Size: 395 amino acids; 43661 Da
Cofactor: Binds 2 divalent ions per subunit. Magnesium or cobalt (By similarity)
Cofactor: Binds 1 potassium ion per subunit (By similarity)
Subunit: Heterotetramer composed of 2 catalytic alpha subunits (alpha and alpha') (MAT2A) and 1 copy of beta
subunit (MAT2B)
1 PDB 3D structure from and Proteopedia for MAT2A:
2P02 (3D)    
Secondary accessions: A8K511 D6W5L1 Q53SP5

Explore the universe of human proteins at neXtProt for MAT2A: NX_P31153

Explore proteomics data for MAT2A at MOPED

Post-translational modifications: 

  • The alpha' subunit is a post-translationally modified version of MAT2A1
  • Ubiquitination2 at Lys61, Lys81, Lys97, Lys228, Lys234, Lys350, Lys351, Lys367
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAT2A (P31153) (see all 34)
     TKVDRSA  IGAGDQG  DYQKVVR  PLSISIF 


    See MAT2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005902.1  
    ENSEMBL proteins: 
     ENSP00000303147   ENSP00000386353  
    Reactome Protein details: P31153

    MAT2A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MAT2A
    OriGene Protein Over-expression Lysate for MAT2A
    OriGene MassSpec for MAT2A
    OriGene Custom Protein Services for MAT2A
    GenScript Custom Purified and Recombinant Proteins Services for MAT2A
    Novus Biologicals MAT2A Proteins
    Novus Biologicals MAT2A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MAT2A
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MAT2A 

    MAT2A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MAT2A
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    Novus Biologicals MAT2A Antibodies
    Abcam antibodies for MAT2A
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for MAT2A
    LSBio Antibodies in human, mouse, rat for MAT2A

    MAT2A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAT2A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAT2A
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for MAT2A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR022636 S-AdoMet_synthetase_sfam
     IPR022628 S-AdoMet_synt_N
     IPR022631 ADOMET_SYNTHASE_CS
     IPR022630 S-AdoMet_synt_C
     IPR002133 S-AdoMet_synthetase

    Graphical View of Domain Structure for InterPro Entry P31153

    ProtoNet protein and cluster: P31153

    1 Blocks protein domain: IPB002133 S-adenosylmethionine synthetase

    UniProtKB/Swiss-Prot: METK2_HUMAN, P31153
    Similarity: Belongs to the AdoMet synthase family


    Find genes that share domains with MAT2A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: METK2_HUMAN, P31153
    Function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP
    Catalytic activity: ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine

         Genatlas biochemistry entry for MAT2A:
    methionine adenosyltransferase,extrahepatic isoform,catalytic specific,subunit alpha,expressed in fetal
    liver,brain,testis,kidney,lymphocytes,sulfur aminoacid metabolism

         Enzyme Number (IUBMB): EC 2.5.1.61 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004478methionine adenosyltransferase activity IDA10644686
    GO:0005515protein binding IPI10644686
    GO:0005524ATP binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with MAT2A           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MAT2A:
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mat2a):
     behavior/neurological  nervous system 

    Find genes that share phenotypes with MAT2A           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAT2A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAT2A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAT2A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAT2A

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAT2A:
    hsa-mir-125a-5p (MIRT045753), hsa-mir-324-3p (MIRT042847), hsa-mir-30a-5p (MIRT005213), hsa-mir-26b-5p (MIRT029216), hsa-mir-186-5p (MIRT044919), hsa-mir-106b-5p (MIRT044305), hsa-mir-193b-3p (MIRT016409), hsa-mir-196b-5p (MIRT042675), hsa-mir-326 (MIRT043644)

    Block miRNA regulation of human, mouse, rat MAT2A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAT2A (see all 50):
    hsa-miR-21* hsa-miR-3164 hsa-miR-122* hsa-miR-1197 hsa-miR-631 hsa-miR-488 hsa-miR-30d hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidMAT2A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAT2A
    Predesigned siRNA for gene silencing in human, mouse, rat MAT2A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAT2A

    Clone
    Products:
         
    OriGene clones in human, mouse for MAT2A (see all 8)
    OriGene ORF clones in mouse, rat for MAT2A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAT2A (NM_005911)
    Sino Biological Human cDNA Clone for MAT2A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAT2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAT2A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAT2A
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAT2A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAT2A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0048269methionine adenosyltransferase complex IDA10644686

    Find genes that share ontologies with MAT2A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAT2A About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1One carbon pool by folate
    Trans-sulfuration and one carbon metabolism0.43
    Methionine metabolism0.35
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Sulfur amino acid metabolism
    Sulfur amino acid metabolism0.35
    Cysteine and methionine metabolism0.35
    4Biological oxidations
    Biological oxidations0.56
    Methylation0.00
    Phase II conjugation0.56
    5superpathway of methionine degradation
    superpathway of methionine degradation
    cysteine biosynthesis III (mammalia)0.00


    Find genes that share SuperPaths with MAT2A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for MAT2A
        Methionine metabolism

    Selected BioSystems Pathways for MAT2A (see all 6)
        C-MYB transcription factor network
    methionine degradation I (to homocysteine)
    Trans-sulfuration and one carbon metabolism
    superpathway of methionine degradation
    S-adenosyl-L-methionine biosynthesis


    2 Reactome Pathways for MAT2A
        Sulfur amino acid metabolism
    Methylation


    3 Kegg Pathways  (Kegg details for MAT2A):
        Cysteine and methionine metabolism
    Metabolic pathways
    Biosynthesis of amino acids

    UniProtKB/Swiss-Prot: METK2_HUMAN, P31153
    Pathway: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine:
    step 1/1

        Pathway & Disease-focused RT2 Profiler PCR Array including MAT2A: 

              Circadian Rhythms in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MAT2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAT2A (P311533 ENSP000003031474) via UniProtKB, MINT, STRING, and/or I2D (see all 162)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=1 STRING: ENSP00000363970
    SAP18O004223, ENSP000003719734I2D: score=1 STRING: ENSP00000371973
    MAT2BQ9NZL93, ENSP000003254254I2D: score=2 STRING: ENSP00000325425
    HGSO149643, ENSP000003312014I2D: score=1 STRING: ENSP00000331201
    CBX8Q9HC523, ENSP000002693854I2D: score=1 STRING: ENSP00000269385
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0006556S-adenosylmethionine biosynthetic process IEA--
    GO:0006730one-carbon metabolic process IEA--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0032259methylation TAS--

    Find genes that share ontologies with MAT2A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAT2A (METK2)

    5 HMDB Compounds for MAT2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CobaltCo (see all 6)7440-48-4--
    L-Methionine(2S)-2-amino-4-(methylsulfanyl)butanoic acid (see all 54)63-68-3--
    MagnesiumMagnesium (see all 2)7439-95-4--
    PotassiumK+ (see all 16)7440-09-7--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    2 DrugBank Compounds for MAT2A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Methionine(S)-2-amino-4-(methylthio)butanoic acid (see all 6)63-68-3enzymesubstrate17154373 17317269 17631143 16482628
    S-AdenosylmethionineAcylcarnitine (see all 6)29908-03-0targetcofactor12023972 12671891 12660248 11596649

    3 Novoseek inferred chemical compound relationships for MAT2A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    s-adenosylmethionine 89.3 77 17869084 (6), 17631143 (5), 18041713 (3), 19048023 (3) (see all 23)
    methionine 84 53 12660248 (8), 19048023 (2), 17869084 (2), 9188509 (2) (see all 21)
    5-methylthioadenosine 79.4 11 17631143 (4), 18041713 (2), 12660248 (1)



    Find genes that share compounds with MAT2A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAT2A gene: 
    NM_005911.5  

    Unigene Cluster for MAT2A:

    Methionine adenosyltransferase II, alpha
    Hs.516157  [show with all ESTs]
    Unigene Representative Sequence: NM_005911
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306434(uc002spr.3) ENST00000465151 ENST00000469221 ENST00000481412(uc010fgm.1)
    ENST00000409017(uc010ysr.2 uc010fgl.2) ENST00000490878
    miRNA
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    Block miRNA regulation of human, mouse, rat MAT2A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAT2A (see all 50):
    hsa-miR-21* hsa-miR-3164 hsa-miR-122* hsa-miR-1197 hsa-miR-631 hsa-miR-488 hsa-miR-30d hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidMAT2A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MAT2A
    Predesigned siRNA for gene silencing in human, mouse, rat MAT2A
    Clone
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    OriGene clones in human, mouse for MAT2A (see all 8)
    OriGene ORF clones in mouse, rat for MAT2A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAT2A (NM_005911)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAT2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAT2A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAT2A
    OriGene qSTAR qPCR primer pairs in human, mouse for MAT2A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAT2A
      QuantiTect SYBR Green Assays in human, mouse, rat MAT2A
      QuantiFast Probe-based Assays in human, mouse, rat MAT2A

    Additional mRNA sequence: 

    AK291126.1 AK293841.1 AK294208.1 AK297758.1 AK297797.1 AK303877.1 AK308591.1 AK308758.1 
    AK309338.1 AK311142.1 AK311612.1 AK316411.1 BC001686.2 BC001854.2 DQ083239.1 X68836.1 

    Selected DOTS entries (see all 45):

    DT.40295726  DT.85101185  DT.97862448  DT.75171568  DT.85101167  DT.100878478  DT.95375821  DT.97862445 
    DT.100031631  DT.121022881  DT.95139354  DT.121023010  DT.120865169  DT.100878485  DT.91842399  DT.121022873 
    DT.95375815  DT.121022946  DT.121022885  DT.121022889  DT.75147741  DT.95375824  DT.100878459  DT.120865165 

    Selected AceView cDNA sequences (see all 828):

    AW473222 BE301157 AI784568 BM759806 BM784201 BE312793 AI912460 AI695793 
    F07982 CD109105 BF446234 CB267758 BM765941 BM822241 BM459514 BM835595 
    BP375808 BQ881266 BP357720 BM760872 AI626096 AL041029 CA426219 AW516900 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAT2A (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
    SP1:                                -     -           -                 -                             -         
    SP2:                                -     -           -                                                         
    SP3:                                -     -                                                                     
    SP4:                                -     -                             -                                       
    SP5:                                                                    -                                       


    ECgene alternative splicing isoforms for MAT2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAT2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGCTTGCC
    MAT2A Expression
    About this image


    MAT2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    MAT2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAT2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516157
        Pathway & Disease-focused RT2 Profiler PCR Array including MAT2A: 
              Circadian Rhythms in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MAT2A
    OriGene qSTAR qPCR primer pairs in human, mouse for MAT2A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAT2A
    QuantiTect SYBR Green Assays in human, mouse, rat MAT2A
    QuantiFast Probe-based Assays in human, mouse, rat MAT2A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAT2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAT2A gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mat2a1 , 5 methionine adenosyltransferase II, alpha1, 5 93.16(n)1
    99.49(a)1
      6 (32.27 cM)5
    2320871  NM_145569.41  NP_663544.11 
     724327995 
    chicken
    (Gallus gallus)
    Aves --
    S-adenosylmethionine synthase
    72(a)
    many ↔ many
    Z(53262872-53287724) ENSGALG00000015366
    lizard
    (Anolis carolinensis)
    Reptilia MAT2A6
    methionine adenosyltransferase II, alpha
    91(a)
    1 ↔ 1
    GL343545.1(383347-397095)
    African clawed frog
    (Xenopus laevis)
    Amphibia m(2)21ab-prov2 methionine adenosyltransferase II 79.12(n)    BC043970.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mat2ab1 methionine adenosyltransferase II, alpha b 75.51(n)
    90.06(a)
      791612  NM_001014296.1  NP_001014318.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta M(2)21AB3
    Sam-S1
    S-adenosylmethionine biosynthesis
    methionine adenosyltransferase3
    S-adenosylmethionine Synthetase1
    74(a)3
    67.71(n)1
    74.61(a)1
      485521  NM_080184.21  NP_524923.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C06E7.1a3
    sams-31
    S-adenosylmethionine synthetase3
    sams-31
    74(a)
    (best of 2)3
    66.67(n)1
    74.27(a)1
      IV(5848877-5850786)3
    1773551  NM_068471.51  NP_500872.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SAM11 SAM1 63.51(n)
    68.16(a)
      850877   NP_013281.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MAT31 MAT3 63.23(n)
    66.93(a)
      818260  NM_001124986.1  NP_001118458.1 


    ENSEMBL Gene Tree for MAT2A (if available)
    TreeFam Gene Tree for MAT2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAT2A gene
    MAT1A2  
    1 SIMAP similar gene for MAT2A using alignment to 3 protein entries:     METK2_HUMAN (see all proteins):
    MAT1A

    Find genes that share paralogs with MAT2A           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for MAT2A
    PGOHUM00000239890 PGOHUM00000237723


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAT2A (see all 213)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1504074251,2
    --85628200(+) TATCCC/TGACAG 1 -- us2k10--------
    rs1153204981,2
    C,F--85628264(+) AGCTTA/CCATTA 1 -- us2k12Minor allele frequency- C:0.01WA 694
    rs1143423561,2
    C,F--85628296(+) CTGTGC/TTAAAG 1 -- us2k12Minor allele frequency- T:0.01WA 694
    rs1896621721,2
    --85628301(+) CTAAAA/GACTCT 1 -- us2k10--------
    rs1822988921,2
    --85628337(+) CAATCC/TTATGA 1 -- us2k10--------
    rs130200281,2
    C,F--85628525(+) GTTGGT/CAGCAC 1 -- us2k13Minor allele frequency- C:0.02NA 580
    rs729405561,2
    C,F--85628596(+) ATAAAA/TTAACC 1 -- us2k13Minor allele frequency- T:0.05WA 696
    rs1141795781,2
    C,F--85628672(+) CACACG/ACATTT 1 -- us2k12Minor allele frequency- A:0.01NA 696
    rs751919711,2
    C,F--85628785(+) ATGAAG/AGGTTA 1 -- us2k12Minor allele frequency- A:0.01WA 694
    rs1854634381,2
    --85628829(+) CATCAC/TCTATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAT2A (85766101 - 85772403 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MAT2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2811CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAT2A
    DNA2.0 Custom Variant and Variant Library Synthesis for MAT2A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601468    OMIM disorders: --

    2 diseases for MAT2A:    
    About MalaCards
    glycine n-methyltransferase deficiency    hypermethioninemia

    2 diseases from the University of Copenhagen DISEASES database for MAT2A:
    Hypermethioninemia     Hepatocellular carcinoma

    Find genes that share disorders with MAT2A           About GenesLikeMe

    3 Novoseek inferred disease relationships for MAT2A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 52.1 6 11208539 (1), 11427482 (1), 17154373 (1), 14530285 (1) (see all 6)
    tumors 0 6 14530285 (1), 18045590 (1), 14578171 (1)
    cancer 0 8 11208539 (1), 11427482 (1), 14530285 (1), 18095270 (1) (see all 7)

    Genetic Association Database (GAD): MAT2A
    Human Genome Epidemiology (HuGE) Navigator: MAT2A (10 documents)

    Export disorders for MAT2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAT2A gene, integrated from 10 sources (see all 89):
    (articles sorted by number of sources associating them with MAT2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and developmental expression of a human kidney S- adenosylmethionine synthetase. (PubMed id 1426236)1, 2, 3 Horikawa S. and Tsukada K. (FEBS Lett. 1992)
    2. Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. (PubMed id 17631143)1, 7, 9 Chen H....Lu S.C. (Gastroenterology 2007)
    3. L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine. (PubMed id 12660248)1, 7, 9 MartA-nez-Chantar M.L....Avila M.A. (J. Biol. Chem. 2003)
    4. Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II). (PubMed id 10644686)1, 2, 9 LeGros H.L.... Kotb M. (J. Biol. Chem. 2000)
    5. Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma. (PubMed id 12671891)1, 7, 9 Martinez-Chantar M.L.... Mato J.M. (Gastroenterology 2003)
    6. Cloning and functional characterization of the 5'-flanking region of human methionine adenosyltransferase 2A gene. (PubMed id 9703951)1, 3, 9 Mao Z....Lu S.C. (Biochem. Biophys. Res. Commun. 1998)
    7. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    8. A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk. (PubMed id 20615890)1, 4 Levine A.J....Haile R.W. (amp 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Genetic association study of putative functional single nucleotide polymorphisms of genes in folate metabolism and spina bifida. (PubMed id 19683694)1, 4 Martinez C.A....Au K.S. (Am. J. Obstet. Gynecol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4144 HGNC: 6904 AceView: MAT2A Ensembl:ENSG00000168906 euGenes: HUgn4144
    ECgene: MAT2A Kegg: 4144 H-InvDB: MAT2A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAT2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAT2A gene:
    Search GeneIP for patents involving MAT2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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