MAT1A Gene
protein-coding GIFtS: 65
GCID: GC10M082021
|
|
methionine adenosyltransferase I, alpha
| |
Aliases
for MAT1A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Methionine Adenosyltransferase I, Alpha1 2 | | MAT-I/III2 3 | | MATA11 2 3 5 | | MAT 12 3 | | SAMS11 2 5 | | EC 2.5.1.63 8 | | MAT1 2 | | AdoMet Synthetase 12 | | SAMS1 2 | | S-Adenosylmethionine Synthase Isoform Type-12 | | AdoMet Synthase 12 3 | | S-Adenosylmethionine Synthetase Isoform Type-12 | | Methionine Adenosyltransferase 12 3 | | AMS13 | | Methionine Adenosyltransferase I/III2 3 | | |
Export aliases for MAT1A gene to outside databasesPrevious GC identifers: GC10M080988 GC10M081253 GC10M082162 GC10M081696 GC10M075874 |
Summaries
for MAT1A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAT1A:
This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to formS-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is thesource of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or ahomodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene areassociated with methionine adenosyltransferase deficiency. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: METK1_HUMAN, Q00266Function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP
|
Genomic Views
for MAT1A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAT1A gene promoter:
LHX3b/Lhx3b AML1a Nkx2-2 Brachyury C/EBPalpha FOXO1a LHX3a/Lhx3a Zic3 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAT1A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAT1A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q22 Ensembl cytogenetic band: 10q23.1 HGNC cytogenetic band: 10q22MAT1A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M082021: view genomic region
(about GC identifiers)
Start:
|
82,031,576 bp from pter |
End:
|
82,049,440 bp from pter |
Size:
|
17,865 bases |
Orientation:
|
minus strand |
|
Proteins
for MAT1A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: METK1_HUMAN, Q00266 (See
protein sequence)Recommended Name: S-adenosylmethionine synthase isoform type-1 Size: 395 amino acids; 43648 Da
Cofactor: Binds 2 divalent ions per subunit. Magnesium or cobalt (By similarity)
Cofactor: Binds 1 potassium ion per subunit (By similarity)
Subunit: Homotetramer (MAT-I) or homodimer (MAT-III)
1 PDB 3D structure from  and Proteopedia  for MAT1A:2OBV (3D)
Secondary accessions: D3DWD5 Q5QP09Explore the universe of human proteins at neXtProt for MAT1A: NX_Q00266
Post-translational modifications:
S-nitrosylation of Cys-120 inactivates the enzyme (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q00266
4/32 DME Specific Peptides for MAT1A (Q00266) (see all 32)
MAT1A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000420.1
ENSEMBL proteins: ENSP00000361287 ENSP00000414961 ENSP00000361280 Reactome Protein details: Q00266
Human Recombinant Protein Products for MAT1A:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- |
MAT1A for ontologies About GeneDecksing
MAT1A Antibody Products:
Assay Products for MAT1A: |
Protein
Domains /
Families
for MAT1A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAT1A for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q00266ProtoNet protein and cluster: Q00266 1 Blocks protein family: IPB002133 S-adenosylmethionine synthetase
UniProtKB/Swiss-Prot: METK1_HUMAN, Q00266Similarity: Belongs to the AdoMet synthase family |
Function
for MAT1A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: METK1_HUMAN, Q00266Function: Catalyzes the formation of S-adenosylmethionine from methionine and ATPCatalytic activity: ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine Genatlas biochemistry entry for MAT1A:methionine adenosyltransferase,specifically expressed in liver,sulfur aminoacid metabolism
Enzyme Number (IUBMB): EC 2.5.1.61 2
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004478 | methionine adenosyltransferase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
MAT1A for ontologies About GeneDecksing
Phenotypes:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Mat1a):
MAT1A for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Mat1atm1Jmm for MAT1A
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAT1A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAT1A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MAT1A (NM_000429) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAT1A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAT1A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAT1A |
|
Pathways & Interactions
for MAT1A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Methionine metabolism | | | 2 | Sulfur amino acid metabolism | | | 3 | Metabolism | | | 4 | Biological oxidations | | | 5 | Metabolism of amino acids and derivatives | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for MAT1A
1  GeneGo (Thomson Reuters) Pathway for MAT1A
5  BioSystems Pathways for MAT1A
5/6 
Reactome Pathways for MAT1A (see all 6)
2 
Kegg Pathways (Kegg details for MAT1A):
UniProtKB/Swiss-Prot: METK1_HUMAN, Q00266Pathway: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step1/1
MAT1A for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAT1A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/130 Interacting proteins for MAT1A (Q002663 ENSP000003612874) via UniProtKB, MINT, STRING, and/or I2D (see all 130)
About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000096 | sulfur amino acid metabolic process |
TAS | -- | | GO:0006520 | cellular amino acid metabolic process |
TAS | 1772450 | | GO:0006556 | S-adenosylmethionine biosynthetic process |
IEA | -- | | GO:0006730 | one-carbon metabolic process |
IEA | -- | | GO:0006805 | xenobiotic metabolic process |
TAS | -- |
MAT1A for ontologies About GeneDecksing
|
Drugs & Compounds
for MAT1A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MAT1A for compounds About GeneDecksing
 Browse Tocris compounds for MAT1A
10/12 HMDB Compounds for MAT1A (see all 12) About this table
5 DrugBank Compounds for MAT1A About this table
10/18 Novoseek chemical compound relationships for MAT1A gene (see all 18) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| s-adenosylmethionine |
92.9 |
136 |
16054984 (4), 11520127 (3), 16958675 (3), 9537246 (2) (see all 60) |
| methionine |
88.8 |
133 |
10677294 (3), 10514445 (3), 11278456 (3), 10415148 (2) (see all 75) |
| cystathionine |
77.2 |
2 |
11131452 (1), 15963701 (1) |
| 5-methylthioadenosine |
75.9 |
2 |
18041713 (1) |
| s-adenosylhomocysteine |
75.9 |
8 |
11520127 (1), 9217094 (1), 9537246 (1), 15122759 (1) (see all 5) |
| ethionine |
69.1 |
4 |
8903381 (1), 17441811 (1) |
| homocysteine |
47.7 |
4 |
20335551 (2), 10677294 (1), 12145770 (1) |
| atp |
38.7 |
15 |
10567242 (2), 9337154 (1), 8903381 (1), 18793149 (1) (see all 11) |
| levodopa |
21.6 |
11 |
8479601 (5), 11520127 (2), 16340382 (1) |
| cysteine |
16.6 |
3 |
9337154 (1), 18752204 (1) |
Search CenterWatch for drugs/clinical trials and news about MAT1A / METK1
|
Transcripts
for MAT1A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAT1A gene: NM_000429.2 Unigene Cluster for MAT1A: Methionine adenosyltransferase I, alpha Hs.282670 [show with all ESTs]Unigene Representative Sequence: NM_0004295 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000485270 ENST00000372213(uc001kbw.3) ENST00000480845 ENST00000455001
ENST00000372206
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAT1A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAT1A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MAT1A (NM_000429) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAT1A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAT1A |
Additional cDNA sequence: AK026931.1 AK290820.1 BC018359.1 D49357.1 X69078.1 8 DOTS entries: DT.449162 DT.100785276 DT.100785275 DT.100649954 DT.100785277 DT.92421482 DT.95155219 DT.97806543 24/109 AceView cDNA sequences (see all 109): BG031941 BM905307 BU188637 AI184830 BX448255 CR600407 W73594 BU165924 T28566 BX496326 BF796302 BG617167 H78095 AI040981 AI144381 BM738684 BX365507 BX507407 AA001252 BX495906 BI836692 N99511 AK026931 BV185727
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for MAT1A About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MAT1A
|
Expression
for MAT1A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAT1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAATTCAGA
About this image
See MAT1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAT1A
SOURCE GeneReport for Unigene cluster: Hs.282670
UniProtKB/Swiss-Prot: METK1_HUMAN, Q00266Tissue specificity: Expressed in liver
SABiosciences Expression via Pathway-Focused PCR Array including MAT1A:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAT1A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAT1A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAT1A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAT1A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAT1A |
Orthologs
for MAT1A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MAT1A gene from 9/37 species (see all 37) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mat1a1 , 5 |
methionine adenosyltransferase I, alpha1, 5 |
88.52(n)1
96.46(a)1 |
|
14 (22.36 cM)5
117201 NM_133653.21 NP_598414.11
411053815 |
chicken
(Gallus gallus) |
Aves |
MAT1A1 |
methionine adenosyltransferase I, alpha |
78.31(n)
91.14(a) |
|
423628 NM_001199519.1 NP_001186448.1 |
lizard
(Anolis carolinensis) |
Reptilia |
MAT1A6 |
-- |
85(a) |
1 ↔ 1 |
GL343233.1(1714507-1735685) |
zebrafish
(Danio rerio) |
Actinopterygii |
wufi35e012 |
wufi35e01 |
78.27(n) |
|
334195 BC045343.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
M(2)21AB3 |
S-adenosylmethionine biosynthesis methionine
adenosyltransferase less |
72(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
C06E7.1a3 |
S-adenosylmethionine synthetase |
72(a)
(best of 2) |
|
IV(5848877-5850786) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
MTO31 |
S-adenosylmethionine synthase 4 |
60.9(n)
63.03(a) |
|
821003 NM_112618.3 NP_188365.1 |
rice
(Oryza sativa) |
Liliopsida |
AK103157.12 |
-- |
75.48(n) |
|
AK103157.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
metK6 |
S-adenosylmethionine synthetase |
56(a) |
possible ortholog |
Chromosome(3084728-3085882) |
ENSEMBL Gene Tree for MAT1A (if available)
TreeFam Gene Tree for MAT1A (if available) |
Paralogs
for MAT1A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAT1A gene
- MAT2A2
1 SIMAP similar gene for MAT1A using alignment to 2 protein entries: METK1_HUMAN (see all proteins):MAT2A
MAT1A for paralogs About GeneDecksing
|
Genomic Variants
for MAT1A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAT1A (82031576 - 82049440 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MAT1A: --
Human Gene Mutation Database (HGMD): MAT1A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAT1A |
|
Disorders
/ Diseases
for MAT1A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAT1A for disorders About GeneDecksing
OMIM gene information: 610550
OMIM disorders: 250850
UniProtKB/Swiss-Prot: METK1_HUMAN, Q00266
Defects in MAT1A are the cause of methionine adenosyltransferase deficiency (MATD) [MIM:250850]; also calledMAT I/III deficiency. MATD is an inborn error of metabolism resulting in isolated hypermethioninemia. Most patientshave no clinical abnormalities, although some neurologic symptoms may be present in rare cases with severe loss ofmethionine adenosyltransferase activity
20/35  diseases for MAT1A (see all 35): About MalaCardsmethionine adenosyltransferase deficiency hypermethioninemia, persistent, autosomal dominant, due to methionine adenosyltransferase i/iii deficiency methionine adenosyltransferase deficiency, autosomal recessive glycine n-methyltransferase deficiency
beta-ketothiolase deficiency superior mesenteric artery syndrome isolated persistent hypermethioninemia hypermethioninemia
ketothiolase deficiency myofibrillar myopathy spina bifida amyotrophic lateral sclerosis
homocystinuria liver cirrhosis lateral sclerosis liver disease
parkinson's disease hepatocellular carcinoma myopathy liver cancer
4 diseases from the University of Copenhagen DISEASES database for MAT1A:Hypermethioninemia Homocystinuria Superior mesenteric artery syndrome Hepatocellular carcinoma 10/12 Novoseek disease relationships for MAT1A gene (see all 12) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hypermethioninemia |
96 |
12 |
9482646 (2), 11278456 (2), 9363660 (2), 10677294 (1) (see all 7) |
| beta-ketothiolase deficiency |
83.6 |
5 |
10674710 (2), 7573050 (1), 7560086 (1) |
| homocystinuria |
68.9 |
2 |
11278456 (1) |
| hepatocellular carcinoma |
61.4 |
9 |
20363925 (2), 11427482 (1), 17154373 (1), 8903381 (1) (see all 8) |
| liver diseases alcoholic |
49.3 |
6 |
16958675 (2), 9337154 (1), 16054984 (1) |
| chronic liver disease |
43.9 |
2 |
15067322 (1), 16054984 (1) |
| demyelination |
41.7 |
8 |
10677294 (2), 9482646 (2), 8770875 (2), 10674710 (1) |
| cirrhosis |
34.4 |
2 |
11131452 (1), 18336669 (1) |
| liver cirrhosis |
18.3 |
1 |
11131452 (1) |
| parkinson disease |
8.9 |
1 |
9217094 (1) |
Genatlas disease: MAT1A hypermethioninemia,persistent with brain demyelination in homozygote
Human Genome Epidemiology (HuGE) Navigator: MAT1A (11 documents)
Export disorders for MAT1A gene to outside databases
|
Publications
for MAT1A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAT1A gene, integrated from 9 sources (see all 130):
(articles sorted by number of sources associating them with MAT1A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of a full-length cDNA encoding human liver S- adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies. (PubMed id 8393662)1, 2, 3 Alvarez L.... Mato J.M. (1993)
- Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency. (PubMed id 8770875)1, 2, 9 Chamberlin M.E....Chou J.Y. (1996)
- Methionine adenosyltransferase I/III deficiency: novel mutations and clinical variations. (PubMed id 10677294)1, 2, 9 Chamberlin M.E.... Chou J.Y. (2000)
- Molecular mechanisms of an inborn error of methionine pathway. Methionine adenosyltransferase deficiency. (PubMed id 7560086)1, 2, 9 Ubagai T.... Chou J.Y. (1995)
- Dominant inheritance of isolated hypermethioninemia is associated with a mutation in the human methionine adenosyltransferase 1A gene. (PubMed id 9042912)1, 2, 9 Chamberlin M.E.... Chou J.Y. (1997)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Molecular cloning and nucleotide sequence of cDNA encoding the human liver S-adenosylmethionine synthetase. (PubMed id 1772450)1, 2 Horikawa S. and Tsukada K. (1991)
- MAT1A variants are associated with hypertension, stro ke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folat e. (PubMed id 20335551)1, 9 Lai C.Q....OrdovA!s J.M. (2010)
- Thyroid hormone receptor-mediated regulation of the m ethionine adenosyltransferase 1 gene is associated with cell invasion in hepato ma cell lines. (PubMed id 20146079)1, 9 Wu S.M....Lin K.H. (2010)
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External Searches for MAT1A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing MAT1A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing MAT1A gene
(According to HUGE)
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Specialized Databases showing MAT1A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for MAT1A | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MAT1A |
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| Patent Information for MAT1A gene:
Search GeneIP for patents involving MAT1A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MAT1A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for MAT1A | | OriGene shRNA RFP for MAT1A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAT1A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAT1A | | | OriGene Protein Over-expression Lysate for MAT1A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAT1A | | OriGene 3'-UTR Clone for MAT1A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAT1A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAT1A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MAT1A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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