Aliases for MAT1A Gene
External Ids for MAT1A Gene
Previous GeneCards Identifiers for MAT1A Gene
This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAT1A Gene
MAT1A (Methionine Adenosyltransferase 1A) is a Protein Coding gene. Diseases associated with MAT1A include hypermethioninemia, persistent, autosomal dominant, due to methionine adenosyltransferase i/iii deficiency and brain demyelination due to methionine adenosyltransferase deficiency. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include methionine adenosyltransferase activity. An important paralog of this gene is MAT2A.
UniProtKB/Swiss-Prot for MAT1A Gene
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.