Aliases for MAT1A Gene
External Ids for MAT1A Gene
Previous GeneCards Identifiers for MAT1A Gene
This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAT1A Gene
MAT1A (Methionine Adenosyltransferase I, Alpha) is a Protein Coding gene. Diseases associated with MAT1A include brain demyelination due to methionine adenosyltransferase deficiency and hypermethioninemia, persistent, autosomal dominant, due to methionine adenosyltransferase i/iii deficiency. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include methionine adenosyltransferase activity. An important paralog of this gene is MAT2A.
UniProtKB/Swiss-Prot for MAT1A Gene
Catalyzes the formation of S-adenosylmethionine from methionine and ATP