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Aliases for MAT1A Gene

Aliases for MAT1A Gene

  • Methionine Adenosyltransferase 1A 2 3
  • Methionine Adenosyltransferase I, Alpha 2 3 5
  • Methionine Adenosyltransferase I/III 3 4
  • Methionine Adenosyltransferase 1 3 4
  • AdoMet Synthase 1 3 4
  • EC 4 63
  • MAT-I/III 3 4
  • MAT 1 3 4
  • MATA1 3 4
  • S-Adenosylmethionine Synthetase Isoform Type-1 3
  • S-Adenosylmethionine Synthetase 2
  • AdoMet Synthetase 1 3
  • SAMS1 3
  • SAMS 3
  • AMS1 4
  • MAT 3

External Ids for MAT1A Gene

Previous GeneCards Identifiers for MAT1A Gene

  • GC10M080988
  • GC10M081253
  • GC10M082162
  • GC10M081696
  • GC10M082021
  • GC10M075874

Summaries for MAT1A Gene

Entrez Gene Summary for MAT1A Gene

  • This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAT1A Gene

MAT1A (Methionine Adenosyltransferase 1A) is a Protein Coding gene. Diseases associated with MAT1A include Hypermethioninemia, Persistent, Autosomal Dominant, Due To Methionine Adenosyltransferase I/Iii Deficiency and Brain Demyelination Due To Methionine Adenosyltransferase Deficiency. Among its related pathways are Phase II conjugation and S-adenosyl-L-methionine biosynthesis. GO annotations related to this gene include methionine adenosyltransferase activity. An important paralog of this gene is MAT2A.

UniProtKB/Swiss-Prot for MAT1A Gene

  • Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAT1A Gene

Genomics for MAT1A Gene

Regulatory Elements for MAT1A Gene

Enhancers for MAT1A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAT1A on UCSC Golden Path with GeneCards custom track

Genomic Location for MAT1A Gene

80,271,820 bp from pter
80,289,979 bp from pter
18,160 bases
Minus strand

Genomic View for MAT1A Gene

Genes around MAT1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAT1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAT1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAT1A Gene

Proteins for MAT1A Gene

  • Protein details for MAT1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    S-adenosylmethionine synthase isoform type-1
    Protein Accession:
    Secondary Accessions:
    • D3DWD5
    • Q5QP09

    Protein attributes for MAT1A Gene

    395 amino acids
    Molecular mass:
    43648 Da
    Name=K(+); Xref=ChEBI:CHEBI:29103;
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Co(2+); Xref=ChEBI:CHEBI:48828;
    Quaternary structure:
    • Homotetramer (MAT-I) or homodimer (MAT-III).

    Three dimensional structures from OCA and Proteopedia for MAT1A Gene

neXtProt entry for MAT1A Gene

Proteomics data for MAT1A Gene at MOPED

Post-translational modifications for MAT1A Gene

Other Protein References for MAT1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MAT1A Gene

Suggested Antigen Peptide Sequences for MAT1A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AdoMet synthase family.
  • Belongs to the AdoMet synthase family.
genes like me logo Genes that share domains with MAT1A: view

No data available for Gene Families for MAT1A Gene

Function for MAT1A Gene

Molecular function for MAT1A Gene

GENATLAS Biochemistry:
methionine adenosyltransferase,specifically expressed in liver,sulfur aminoacid metabolism
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine.
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

Enzyme Numbers (IUBMB) for MAT1A Gene

genes like me logo Genes that share phenotypes with MAT1A: view

Human Phenotype Ontology for MAT1A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MAT1A Gene

MGI Knock Outs for MAT1A:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for MAT1A Gene

Localization for MAT1A Gene

Subcellular locations from

Jensen Localization Image for MAT1A Gene COMPARTMENTS Subcellular localization image for MAT1A gene
Compartment Confidence
cytosol 5
nucleus 2
cytoskeleton 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAT1A Gene

Pathways & Interactions for MAT1A Gene

genes like me logo Genes that share pathways with MAT1A: view

UniProtKB/Swiss-Prot Q00266-METK1_HUMAN

  • Pathway: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.

Interacting Proteins for MAT1A Gene

Selected Interacting proteins: Q00266-METK1_HUMAN for MAT1A Gene via I2D

Gene Ontology (GO) - Biological Process for MAT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000096 sulfur amino acid metabolic process TAS --
GO:0006730 one-carbon metabolic process IEA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0032259 methylation TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with MAT1A: view

No data available for SIGNOR curated interactions for MAT1A Gene

Drugs & Compounds for MAT1A Gene

(20) Drugs for MAT1A Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra Target, cofactor 0
L-Methionine Approved Nutra Enzyme, substrate 0
Adenosine triphosphate Approved Nutra 0
3-Oxiran-2ylalanine Experimental Pharma Target 0
L-2-Amino-4-Methoxy-Cis-but-3-Enoic Acid Experimental Pharma Target 0

(11) Additional Compounds for MAT1A Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • (+-)-Selenomethionine
  • (2S)-2-amino-4-(methylseleno)butanoate
  • (2S)-2-amino-4-(methylseleno)butanoic acid
  • (S)-2-amino-4-(methylseleno)-Butanoate
  • (S)-2-amino-4-(methylseleno)-Butanoic acid
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with MAT1A: view

Transcripts for MAT1A Gene

Unigene Clusters for MAT1A Gene

Methionine adenosyltransferase I, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAT1A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP1: -
SP2: -

Relevant External Links for MAT1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAT1A Gene

mRNA expression in normal human tissues for MAT1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAT1A Gene

This gene is overexpressed in Liver (x50.1).

Protein differential expression in normal tissues from HIPED for MAT1A Gene

This gene is overexpressed in Gallbladder (33.2), Liver (16.4), and Liver, secretome (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MAT1A Gene

SOURCE GeneReport for Unigene cluster for MAT1A Gene Hs.282670

mRNA Expression by UniProt/SwissProt for MAT1A Gene

Tissue specificity: Expressed in liver.
genes like me logo Genes that share expression patterns with MAT1A: view

Protein tissue co-expression partners for MAT1A Gene

Primer Products

Orthologs for MAT1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAT1A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MAT1A 35
  • 89.2 (n)
  • 95.7 (a)
MAT1A 36
  • 96 (a)
(Canis familiaris)
Mammalia MAT1A 35
  • 90.38 (n)
  • 96.2 (a)
MAT1A 36
  • 96 (a)
(Mus musculus)
Mammalia Mat1a 35
  • 88.52 (n)
  • 96.46 (a)
Mat1a 16
Mat1a 36
  • 96 (a)
(Pan troglodytes)
Mammalia MAT1A 35
  • 99.16 (n)
  • 100 (a)
MAT1A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mat1a 35
  • 89.37 (n)
  • 96.2 (a)
(Monodelphis domestica)
Mammalia MAT1A 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia MAT1A 36
  • 80 (a)
(Gallus gallus)
Aves MAT1A 35
  • 78.31 (n)
  • 91.14 (a)
MAT1A 36
  • 91 (a)
(Anolis carolinensis)
Reptilia MAT1A 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mat1a 35
  • 74.51 (n)
  • 85.06 (a)
(Danio rerio)
Actinopterygii mat1a 35
  • 76.87 (n)
  • 84.96 (a)
wufi35e01 35
mat1a 36
  • 83 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.296 35
fruit fly
(Drosophila melanogaster)
Insecta M(2)21AB 37
  • 72 (a)
Sam-S 36
  • 66 (a)
(Caenorhabditis elegans)
Secernentea C06E7.1a 37
  • 72 (a)
C49F5.1 37
  • 69 (a)
sams-1 36
  • 65 (a)
sams-3 36
  • 67 (a)
sams-4 36
  • 67 (a)
sams-5 36
  • 67 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAM1 36
  • 68 (a)
SAM2 36
  • 67 (a)
SAM1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons SAM-2 35
  • 62.07 (n)
  • 62.86 (a)
(Glycine max)
eudicotyledons Gma.1681 35
(Hordeum vulgare)
Liliopsida Hv.2038 35
(Oryza sativa)
Liliopsida Os01g0293000 35
  • 63.84 (n)
  • 63.4 (a)
(Zea mays)
Liliopsida Zm.5785 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4392 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10263 36
  • 61 (a)
Species with no ortholog for MAT1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAT1A Gene

Gene Tree for MAT1A (if available)
Gene Tree for MAT1A (if available)

Paralogs for MAT1A Gene

Paralogs for MAT1A Gene

(1) SIMAP similar genes for MAT1A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MAT1A: view

Variants for MAT1A Gene

Sequence variations from dbSNP and Humsavar for MAT1A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_006935 Methionine adenosyltransferase deficiency (MATD)
VAR_006936 Methionine adenosyltransferase deficiency (MATD)
VAR_006937 Methionine adenosyltransferase deficiency (MATD)
VAR_006938 Methionine adenosyltransferase deficiency (MATD)
VAR_006939 Methionine adenosyltransferase deficiency (MATD)

Variation tolerance for MAT1A Gene

Residual Variation Intolerance Score: 16.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAT1A Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAT1A Gene

Disorders for MAT1A Gene

MalaCards: The human disease database

(10) MalaCards diseases for MAT1A Gene - From: OMIM, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypermethioninemia, persistent, autosomal dominant, due to methionine adenosyltransferase i/iii deficiency
  • methionine adenosyltransferase deficiency, autosomal recessive
brain demyelination due to methionine adenosyltransferase deficiency
  • methionine adenosyltransferase deficiency
  • glycine n-methyltransferase deficiency
superior mesenteric artery syndrome
  • arteriomesenteric duodenal compression syndrome
alpha-methylacetoacetic aciduria
  • beta-ketothiolase deficiency
- elite association - COSMIC cancer census association via MalaCards
Search MAT1A in MalaCards View complete list of genes associated with diseases


  • Methionine adenosyltransferase deficiency (MATD) [MIM:250850]: An inborn error of metabolism resulting in isolated hypermethioninemia. Most patients have no clinical abnormalities, although some neurologic symptoms may be present in rare cases with severe loss of methionine adenosyltransferase activity. {ECO:0000269 PubMed:10677294, ECO:0000269 PubMed:7560086, ECO:0000269 PubMed:8770875, ECO:0000269 PubMed:9042912}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for MAT1A Gene

hypermethioninemia,persistent with brain demyelination in homozygote

Relevant External Links for MAT1A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MAT1A: view

Publications for MAT1A Gene

  1. Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency. (PMID: 8770875) Chamberlin M.E. … Chou J.Y. (J. Clin. Invest. 1996) 3 4 23 48 67
  2. Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells. (PMID: 17154373) Yang H. … Lu S.C. (J. Cell. Physiol. 2007) 23 25 26
  3. Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. (PMID: 17631143) Chen H. … Lu S.C. (Gastroenterology 2007) 23 25 26
  4. S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. (PMID: 16614071) Prudova A. … Banerjee R. (Proc. Natl. Acad. Sci. U.S.A. 2006) 23 25 26
  5. Thyroid hormone receptor-mediated regulation of the methionine adenosyltransferase 1 gene is associated with cell invasion in hepatoma cell lines. (PMID: 20146079) Wu S.M. … Lin K.H. (Cell. Mol. Life Sci. 2010) 3 23

Products for MAT1A Gene

Sources for MAT1A Gene