MASTL Gene
protein-coding GIFtS: 56
GCID: GC10P027484
|
|
microtubule associated serine/threonine kinase-like
| |
Aliases
for MASTL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Microtubule Associated Serine/Threonine Kinase-Like1 2 | | FLJ148131 5 | | THC21 2 3 5 | | GREATWALL2 | | Microtubule-Associated Serine/Threonine-Protein Kinase-Like2 3 | | RP11-85G18.22 | | GW2 3 | | Greatwall Protein Kinase2 | | GWL2 3 | | Serine/Threonine-Protein Kinase Greatwall2 | | MAST-L2 3 | | EC 2.7.11.13 | | HGWL1 | | |
Export aliases for MASTL gene to outside databasesPrevious GC identifers: GC10P027448 GC10P027112 |
Summaries
for MASTL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MASTL:
This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated withautosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants havebeen described for this locus. (provided by RefSeq, Feb 2010)
UniProtKB/Swiss-Prot: GWL_HUMAN, Q96GX5Function: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry andmaintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directlyinhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta)subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNAdamage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro;however such activity is unsure in vivo. May be involved in megakaryocyte differentiation
Gene Wiki entry for MASTL
|
Genomic Views
for MASTL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MASTL gene promoter:
ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for MASTL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MASTL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p12.1 Ensembl cytogenetic band: 10p12.1 HGNC cytogenetic band: 10p12.1MASTL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P027484: view genomic region
(about GC identifiers)
Start:
|
27,443,753 bp from pter |
End:
|
27,475,848 bp from pter |
Size:
|
32,096 bases |
Orientation:
|
plus strand |
|
Proteins
for MASTL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GWL_HUMAN, Q96GX5 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase greatwall Size: 879 amino acids; 97319 Da
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Nucleus. Cleavage furrow. Note=During interphase is mainlynuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes. Uponmitotic exit moves to the cleavage furrow
Miscellaneous: Reduced levels of MASTL by RNAi causes mitotic abnormalities that consist of delay in G(2) phase andslow chromosome condensation. Cells that enter and progress through mitosis often fail to completely separate theirsister chromatids in anaphase leading to the formation of 4N G(1) cells subsequent to failure of cytokinesis(PubMed:20818157 and PubMed:20538976)
Secondary accessions: Q5T8D5 Q5T8D7 Q8NCD6 Q96SJ5Alternative splicing: 3 isoforms: Q96GX5-1 Q96GX5-2 Q96GX5-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MASTL: NX_Q96GX5
Post-translational modifications:
Phosphorylation at Thr-741 by CDK1 during M phase activates its kinase activity (By similarity). Maximumphosphorylation occurs in prometaphase1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96GX5
MASTL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001165774.1 NP_001165775.1 NP_116233.2
ENSEMBL proteins: ENSP00000365113 ENSP00000343446 ENSP00000365107 Reactome Protein details: Q96GX5
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
MASTL for ontologies About GeneDecksing
MASTL Antibody Products:
Assay Products for MASTL: |
Protein
Domains /
Families
for MASTL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MASTL for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96GX5ProtoNet protein and cluster: Q96GX5 1 Blocks protein family: IPB000961 Protein kinase C-terminal domain
UniProtKB/Swiss-Prot: GWL_HUMAN, Q96GX5Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase familySimilarity: Contains 1 AGC-kinase C-terminal domainSimilarity: Contains 1 protein kinase domain |
Function
for MASTL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GWL_HUMAN, Q96GX5Function: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry andmaintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directlyinhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta)subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNAdamage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro;however such activity is unsure in vivo. May be involved in megakaryocyte differentiationCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.11
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MASTL (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MASTL (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): MASTL (NM_032844) | |  | Sino Biological Human cDNA Clone for MASTL | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MASTL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MASTL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MASTL |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004674 | protein serine/threonine kinase activity |
IDA | -- | | GO:0005524 | ATP binding |
IEA | -- | | GO:0016301 | kinase activity |
IDA | -- | | GO:0051721 | protein phosphatase 2A binding |
ISS | -- |
MASTL for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for MASTL:
|
Pathways & Interactions
for MASTL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | M Phase | | | 2 | Cell Cycle | | | 3 | Clearance of Nuclear Envelope Membranes from Chromatin | | | 4 | ERK/MAPK targets | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6 
Reactome Pathways for MASTL (see all 6)
MASTL for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MASTL
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for MASTL (ENSP000003651134) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000086 | G2/M transition of mitotic cell cycle |
IMP | -- | | GO:0006974 | response to DNA damage stimulus |
ISS | -- | | GO:0007067 | mitosis |
IMP | -- | | GO:0016310 | phosphorylation |
-- | -- | | GO:0034048 | negative regulation of protein phosphatase type 2A activity |
IMP | -- |
MASTL for ontologies About GeneDecksing
|
Drugs & Compounds
for MASTL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MASTL
2 HMDB Compounds for MASTL About this table
Search CenterWatch for drugs/clinical trials and news about MASTL / GWL
|
Transcripts
for MASTL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MASTL gene (3 alternative transcripts): NM_001172303.1 NM_001172304.1 NM_032844.3 Unigene Cluster for MASTL: Microtubule associated serine/threonine kinase-like Hs.276905 [show with all ESTs]Unigene Representative Sequence: AK1230044 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000375946(uc001itl.3 uc001itm.3 uc009xkw.2 uc009xkx.2)
ENST00000342386 ENST00000375940 ENST00000477034
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MASTL (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MASTL (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): MASTL (NM_032844) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MASTL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MASTL |
Additional cDNA sequence: AK027719.1 AK074804.1 AK123004.1 AK225319.1 BC009107.1 BC013704.1 14 DOTS entries: DT.109365 DT.101980847 DT.91659769 DT.121215863 DT.100673576 DT.121215847 DT.416839 DT.75111939 DT.99939762 DT.425443 DT.100833006 DT.91929548 DT.102843323 DT.100840954 24/83 AceView cDNA sequences (see all 83): BM679574 CB131307 BU629060 CR592673 BU620318 BU430288 CA944973 BM721150 BU521118 AW675108 CA777146 BF062066 BX338380 CA429284 NM_032844 BG114230 BP339470 BM550518 AI368025 BQ441178 CB215683 BQ224736 BU507765 BU167799
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MASTL (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MASTL
|
Expression
for MASTL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MASTL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCCTGCGGT
About this image
See MASTL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MASTL
SOURCE GeneReport for Unigene cluster: Hs.276905
SABiosciences Custom PCR Arrays for MASTL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MASTL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MASTL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MASTL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MASTL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MASTL |
Orthologs
for MASTL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MASTL gene from 7/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MASTL1 |
microtubule associated serine/threonine kinase-like |
66.63(n)
61.88(a) |
|
420487 XM_418589.3 XP_418589.2 |
lizard
(Anolis carolinensis) |
Reptilia |
MASTL6 |
-- |
57(a) |
1 ↔ 1 |
6(14493010-14510928) |
African clawed frog
(Xenopus laevis) |
Amphibia |
480603222 |
-- |
71.7(n) |
|
48060322 |
zebrafish
(Danio rerio) |
Actinopterygii |
BI886460.12 |
-- |
75.07(n) |
|
334737 BI886460.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
gwl6 |
greatwall |
33(a) |
1 ↔ 1 |
3R(14572092-14576082) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G451606IRE6(see all 4) |
protein kinase-like proteinAGC (cAMP-dependent, cGMP-dependent and protein ki...(see all 4) |
15(a)15(a)(see all 4) |
1 ↔ many1 ↔ many(see all 4) |
1(17083546-17090545) 5(25023355-25028414) |
rice
(Oryza sativa) |
Liliopsida |
Os.319062 |
Oryza sativa (japonica cultivar-group) cDNA clone0 more |
68.31(n) |
|
AK122108.1 |
ENSEMBL Gene Tree for MASTL (if available)
TreeFam Gene Tree for MASTL (if available) |
Paralogs
for MASTL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MASTL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MASTL (27443753 - 27475848 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MASTL
2 CNVs: 5589 5416
Human Gene Mutation Database (HGMD): MASTL
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MASTL |
|
Disorders
/ Diseases
for MASTL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MASTL for disorders About GeneDecksing
OMIM gene information: 608221
OMIM disorders: 188000
UniProtKB/Swiss-Prot: GWL_HUMAN, Q96GX5
Defects in MASTL are the cause of thrombocytopenia type 2 (THC2) [MIM:188000]. Thrombocytopenia is defined bya decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding anddecreased ability for clotting
4  diseases for MASTL: About MalaCardsthrombocytopenia 2 thrombocytopenia gray platelet syndrome alzheimer's disease
Human Genome Epidemiology (HuGE) Navigator: MASTL (1 document)
Export disorders for MASTL gene to outside databases
|
Publications
for MASTL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MASTL gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with MASTL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MASTL is the human orthologue of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis. (PubMed id 20818157)1, 2 Voets E. and Wolthuis R.M.F. (2010)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10. (PubMed id 12890928)1, 2 Gandhi M.J.... Drachman J.G. (2003)
- Thrombocytopenias due to gray platelet syndrome or TH C2 mutations. (PubMed id 22102272)1 Di Paola J. and Johnson J. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Characterization of the mechanisms controlling Greatw all activity. (PubMed id 21444715)1 Vigneron S....Castro A. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for MASTL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MASTL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MASTL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MASTL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MASTL | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MASTL |
|
| | |
About This Section
| Patent Information for MASTL gene:
Search GeneIP for patents involving MASTL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MASTL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MASTL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MASTL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MASTL | | | OriGene Protein Over-expression Lysate for MASTL | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MASTL | | OriGene 3'-UTR Clone for MASTL | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MASTL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MASTL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MASTL | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MASTL | | OriGene Custom Protein Services for MASTL | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MASTL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MASTL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MASTL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MASTL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MASTL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MASTL |
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| | | | Search Tocris compounds for MASTL |
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 | | | MASTL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MASTL |
|  |  |  | | | | ThermoFisher Antibody for MASTL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MASTL |
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