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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MAST4 Gene

protein-coding GIFtS: 55
GCID: GC05P065892

microtubule associated serine/threonine kinase family member...

Explore 3 diseases affiliated with
MAST4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Microtubule Associated Serine/Threonine Kinase Family Member 4¹ ²
KIAA0303¹ ³
EC 2.7.11.1³ ⁸
Microtubule-Associated Serine/Threonine-Protein Kinase 4²
EC 2.7.11⁸

External Ids:	HGNC: 19037¹	Entrez Gene: 375449²	Ensembl: ENSG00000069020⁷	UniProtKB: O15021³

Export aliases for MAST4 gene to outside databases

Previous GC identifers: GC05P066291 GC05P065929 GC05P062849

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006713.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MAST4 gene promoter:
HOXA9B HOXA9 Pbx1a FOXD3 Nkx2-5 NF-kappaB LCR-F1 Meis-1b NF-kappaB1 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAST4 promoter sequence

Search SABiosciences Chromatin IP Primers for MAST4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAST4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.3 Ensembl cytogenetic band: 5q12.3 HGNC cytogenetic band: 5q12.3

MAST4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAST4 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P065892: view genomic region (about GC identifiers)

Start:	65,892,176 bp from pter	End:	66,465,423 bp from pter
Size:	573,248 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MAST4_HUMAN, O15021 (See protein sequence)

Recommended Name: Microtubule-associated serine/threonine-protein kinase 4

Size: 2626 amino acids; 284378 Da

Cofactor: Magnesium (By similarity)

Subcellular location: Cytoplasm (Potential)

1 PDB 3D structure from and Proteopedia for MAST4:

2W7R (3D)

Secondary accessions: A6NL49 B5ME48 Q05EE6 Q6ZN07 Q8N4X4 Q96LY3

Alternative splicing: 5 isoforms: O15021-5 O15021-2 O15021-4 O15021-1 O15021-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAST4: NX_O15021

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O15021

4/34 DME Specific Peptides for MAST4 (O15021) (see all 34)

FFRSLDW

RPRSRSL

KLTDFGL

SYRSTPD

MAST4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001158136.1 NP_055998.1 NP_942123.1

ENSEMBL proteins:

ENSP00000385727 ENSP00000385088 ENSP00000384547 ENSP00000407977 ENSP00000413573

ENSP00000396765 ENSP00000398417 ENSP00000421739 ENSP00000384313 ENSP00000404801

ENSP00000384099 ENSP00000385260 ENSP00000413854 ENSP00000261569 ENSP00000392478

ENSP00000398694 ENSP00000400551 ENSP00000385048

Human Recombinant Protein Products for MAST4:

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	Novus Biologicals MAST4 Proteins Novus Biologicals MAST4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MAST4

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

MAST4 for ontologies About GeneDecksing

MAST4 Antibody Products:

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	Search ThermoFisher Antibodies for MAST4

Assay Products for MAST4:

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	Uscn ELISAs and CLIAs for MAST4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MAST4 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

IPR015022 MA_Ser/Thr_Kinase_dom

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry O15021

ProtoNet protein and cluster: O15021

1 Blocks protein family: IPB000961 Protein kinase C-terminal domain

UniProtKB/Swiss-Prot: MAST4_HUMAN, O15021

Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family

Similarity: Contains 1 AGC-kinase C-terminal domain

Similarity: Contains 1 PDZ (DHR) domain

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MAST4_HUMAN, O15021

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB): EC 2.7.11.1¹ ² EC 2.7.11²

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0005524	ATP binding	IEA	--

MAST4 for ontologies About GeneDecksing

Phenotypes:
5 GenomeRNAi human phenotypes for MAST4:

Cells with protrusions	Decreased Salmonella enterica	Decreased nuclei size in G2M	Decreased substrate adherent c
Synthetic lethal with c-Myc af

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MAST4

miRNA Products:		OriGene 3'-UTR Clone (see all 3): MAST4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAST4
		8/69 QIAGEN miScript miRNA Assays for microRNAs that regulate MAST4 (see all 69):
		hsa-miR-548j hsa-miR-128 hsa-miR-30d hsa-miR-877* hsa-miR-30a hsa-miR-548a-5p hsa-miR-92b hsa-miR-761

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAST4 OriGene shRNA RFP: MAST4 OriGene siRNA: MAST4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAST4
		Sirion Biotech Custom design and validation of potent shRNA sequences against MAST4

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MAST4
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAST4 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAST4 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAST4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MAST4

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for MAST4 (O15021^{2, 3} ENSP00000384313⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMAD1	Q15797²^,³	MINT-62023 I2D: score=2
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MAST4

2 HMDB Compounds for MAST4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

Search CenterWatch for drugs/clinical trials and news about MAST4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MAST4 gene (3 alternative transcripts):

NM_001164664.1 NM_015183.2 NM_198828.2

Unigene Cluster for MAST4:

Microtubule associated serine/threonine kinase family member 4

Hs.595458 [show with all ESTs]

Unigene Representative Sequence: NM_001164664

18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):

ENST00000403625(uc003jut.2 uc003juw.3) ENST00000406374(uc010iwz.3 uc003jur.4)

ENST00000406039 ENST00000478569 ENST00000452953 ENST00000432817 ENST00000451144

ENST00000434115 ENST00000411628 ENST00000490016(uc003jus.3) ENST00000470421

ENST00000403666 ENST00000450827 ENST00000405643(uc003juu.1 uc011cra.1)

ENST00000407621 ENST00000432426 ENST00000261569(uc010ixa.2 uc003juv.2)

ENST00000436277

miRNA Products:		OriGene 3'-UTR Clone (see all 3): MAST4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAST4
		8/69 QIAGEN miScript miRNA Assays for microRNAs that regulate MAST4 (see all 69):
		hsa-miR-548j hsa-miR-128 hsa-miR-30d hsa-miR-877* hsa-miR-30a hsa-miR-548a-5p hsa-miR-92b hsa-miR-761

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAST4 OriGene shRNA RFP: MAST4 OriGene siRNA: MAST4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAST4
		Sirion Biotech Custom design and validation of potent shRNA sequences against MAST4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAST4 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAST4 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): MAST4 (NM_198828)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAST4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAST4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAST4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MAST4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAST4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAST4

Additional cDNA sequence:

AB002301.1 AK057601.1 AK131421.1 AK296707.1 AK299538.1 AK299706.1 AK303578.1 AK309559.1

AY439222.1 AY830839.1 BC003646.2 BC018692.1 BC033215.1 BC068073.1 BC080587.1 BX648796.1

BX648980.1

18 DOTS entries:

DT.452744 DT.91733520 DT.101975463 DT.97783724 DT.91733526 DT.101983320 DT.120800341 DT.425215

DT.100693443 DT.205206 DT.120800347 DT.91694369 DT.92405468 DT.91654527 DT.91805430 DT.97820106

DT.40267949 DT.91698962

1 AceView cDNA sequence:

BG929085

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for MAST4 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17a	·	17b	^	18a	·	18b	·	18c	^	19	^	20	^	21	^	22	^
SP1:																																											-
SP2:
SP3:																																											-						-
SP4:

ExUns:	23	^	24	^	25	^	26
SP1:
SP2:
SP3:
SP4:

ECgene alternative splicing isoforms for MAST4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MAST4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCGGGGCCA

About this image

MAST4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Adipose

Interscapular Brown Adipose Depot

Adipose

Brain

Brain

Neural Tube

Neural Tube

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MAST4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAST4

SOURCE GeneReport for Unigene cluster: Hs.595458

UniProtKB/Swiss-Prot: MAST4_HUMAN, O15021

Tissue specificity: Highly expressed in most normal human tissues, with an exception of in testis, small intestine,

colon and peripheral blood leukocyte

SABiosciences Custom PCR Arrays for MAST4

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAST4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAST4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MAST4 gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mast4^{1 , 5}	microtubule associated serine/threonine kinase family more^{1, 5}	81.94(n)¹ 82.66(a)¹		13 (54.94 cM)⁵ 328329¹ NM_175171.3¹ NP_780380.2¹ 102732486⁵
chicken (Gallus gallus)	Aves	MAST4¹	microtubule associated serine/threonine kinase family more	68.28(n) 69.41(a)		427169 XM_424757.3 XP_424757.3
lizard (Anolis carolinensis)	Reptilia	MAST4⁶	--	66(a)	1 ↔ 1	2(11394163-11467206)
zebrafish (Danio rerio)	Actinopterygii	mast4¹	microtubule associated serine/threonine kinase family more	67.55(n) 72.58(a)		100149322 XM_001922561.2 XP_001922596.2
fruit fly (Drosophila melanogaster)	Insecta	CG6498⁶	--	27(a)	possible ortholog	3L(15559113-15569413)
worm (Caenorhabditis elegans)	Secernentea	kin-4¹	Protein KIN-4	47.88(n) 44.67(a)		178068 NM_069760.3 NP_502161.2

ENSEMBL Gene Tree for MAST4 (if available)
TreeFam Gene Tree for MAST4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MAST4 gene

MAST2² MAST3² MAST1²

18/62 SIMAP similar genes for MAST4 using alignment to 16 protein entries: MAST4_HUMAN (see all proteins) (see all similar genes):

MAST1 MAST3 RPS6KA1 RPS6KA5 SGK3 STK32A

RPS6KA3 RPS6KA2 ARHGAP23 MAST2 PRKACB KIN27

PRKACA MAP4K5 PRKY MAPK8 PRKACG PRKX

MAST4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs180763263^1,2		--	65890241(+)	`TCAGGC/TGATAA`	2	--	us2k¹		0	--	--	--	--
rs150220523^1,2		--	65890249(+)	`TAATAA/GCTATT`	2	--	us2k¹		0	--	--	--	--
rs186020435^1,2		--	65890306(+)	`TCCCTA/GTGTAC`	2	--	us2k¹		0	--	--	--	--
rs12523194^1,2	C,H	--	65890344(+)	`TGTGCA/TTGGCT`	2	--	us2k¹		5		WA NA EA	362
rs6877176^1,2	C,F,A,H	--	65890467(+)	`CCCACT/CGTGCT`	2	--	us2k¹		19		NS EA NA WA CSA	2340
rs191343859^1,2		--	65890519(+)	`TTGACC/TTTTTG`	2	--	us2k¹		0	--	--	--	--
rs182667646^1,2		--	65890565(+)	`GAAGCA/GTCACA`	2	--	us2k¹		0	--	--	--	--
rs75788646^1,2	F	--	65890641(+)	`ATTTCC/TTTCCC`	2	--	us2k¹		1		WA	118
rs138871641^1,2		--	65890665(+)	`GGAGGA/CAACTG`	2	--	us2k¹		0	--	--	--	--
rs73764381^1,2	C,F	--	65890697(+)	`CAATAT/CGATGA`	2	--	us2k¹		4		WA CSA	123

HapMap Linkage Disequilibrium report for MAST4 (65892176 - 66142176 bp, first 250kb of MAST4)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for MAST4
8 CNVs: 47881 99166 99165 64225 51726 47938 3556 99164
2 Indels: 93085 46912
Human Gene Mutation Database (HGMD): MAST4

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAST4

DNA2.0 Custom Variant and Variant Library Synthesis for MAST4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MAST4 for disorders About GeneDecksing

3 diseases for MAST4: About MalaCards

cystic lymphangioma lymphangioma down syndrome

2 diseases from the University of Copenhagen DISEASES database for MAST4:

Down syndrome Cystic lymphangioma

Human Genome Epidemiology (HuGE) Navigator: MAST4 (1 document)

Export disorders for MAST4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MAST4 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with MAST4)

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Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)^{1, 2, 3} Nagase T.... Ohara O. (1997)
Identification of a novel human MAST4 gene, a new member of the microtubule associated serine-threonine kinase family. (PubMed id 17086981)^{1, 2} Sun L....Mao Y. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)¹ Martins-de-Souza D....Bahn S. (2012)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
A genome-wide association study of carotid atheroscle rosis in HIV-infected men. (PubMed id 20009918)¹ Shrestha S....Grunfeld C. (2010)
Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)² Greenman C.... Stratton M.R. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)² Schmutz J.... Rubin E.M. (2004)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 375449	HGNC: 19037	AceView: LOC375449.1	Ensembl:ENSG00000069020	euGenes: HUgn375449
ECgene: MAST4	H-InvDB: MAST4

(According to HUGE)
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HUGE: KIAA0303

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MAST4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MAST4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MAST4 gene:
Search GeneIP for patents involving MAST4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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