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Aliases for MAST4 Gene

Aliases for MAST4 Gene

  • Microtubule Associated Serine/Threonine Kinase Family Member 4 2 3
  • EC 2.7.11.1 4 63
  • EC 2.7.11 63
  • KIAA0303 4

External Ids for MAST4 Gene

Previous GeneCards Identifiers for MAST4 Gene

  • GC05P066291
  • GC05P065929
  • GC05P065892
  • GC05P062849

Summaries for MAST4 Gene

Entrez Gene Summary for MAST4 Gene

  • This gene encodes a member of the microtubule-associated serine/threonine protein kinases. The proteins in this family contain a domain that gives the kinase the ability to determine its own scaffold to control the effects of their kinase activities. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

GeneCards Summary for MAST4 Gene

MAST4 (Microtubule Associated Serine/Threonine Kinase Family Member 4) is a Protein Coding gene. Diseases associated with MAST4 include cystic lymphangioma. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is MAST3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAST4 Gene

Genomics for MAST4 Gene

Regulatory Elements for MAST4 Gene

Genomic Location for MAST4 Gene

Start:
66,596,348 bp from pter
End:
67,169,598 bp from pter
Size:
573,251 bases
Orientation:
Plus strand

Genomic View for MAST4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAST4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAST4 Gene

Proteins for MAST4 Gene

  • Protein details for MAST4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15021-MAST4_HUMAN
    Recommended name:
    Microtubule-associated serine/threonine-protein kinase 4
    Protein Accession:
    O15021
    Secondary Accessions:
    • A6NL49
    • B5ME48
    • Q05EE6
    • Q6ZN07
    • Q8N4X4
    • Q96LY3

    Protein attributes for MAST4 Gene

    Size:
    2626 amino acids
    Molecular mass:
    284378 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MAST4 Gene

    Alternative splice isoforms for MAST4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAST4 Gene

Proteomics data for MAST4 Gene at MOPED

Post-translational modifications for MAST4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for MAST4 Gene

Graphical View of Domain Structure for InterPro Entry

O15021

UniProtKB/Swiss-Prot:

MAST4_HUMAN :
  • O15021
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MAST4: view

Function for MAST4 Gene

Molecular function for MAST4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for MAST4 Gene

Gene Ontology (GO) - Molecular Function for MAST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with MAST4: view
genes like me logo Genes that share phenotypes with MAST4: view

miRNA for MAST4 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MAST4 Gene

Localization for MAST4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAST4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAST4 Gene COMPARTMENTS Subcellular localization image for MAST4 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MAST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MAST4: view

Pathways for MAST4 Gene

SuperPathways for MAST4 Gene

No Data Available

Interacting Proteins for MAST4 Gene

Gene Ontology (GO) - Biological Process for MAST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with MAST4: view

No data available for Pathways by source for MAST4 Gene

Compounds for MAST4 Gene

(2) HMDB Compounds for MAST4 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with MAST4: view

Transcripts for MAST4 Gene

mRNA/cDNA for MAST4 Gene

(15) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(21) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAST4 Gene

Microtubule associated serine/threonine kinase family member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAST4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: -
SP2:
SP3: - -
SP4:

ExUns: 23 ^ 24 ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:

Relevant External Links for MAST4 Gene

GeneLoc Exon Structure for
MAST4
ECgene alternative splicing isoforms for
MAST4

Expression for MAST4 Gene

mRNA expression in normal human tissues for MAST4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAST4 Gene

SOURCE GeneReport for Unigene cluster for MAST4 Gene Hs.595458

mRNA Expression by UniProt/SwissProt for MAST4 Gene

O15021-MAST4_HUMAN
Tissue specificity: Highly expressed in most normal human tissues, with an exception of in testis, small intestine, colon and peripheral blood leukocyte.
genes like me logo Genes that share expressions with MAST4: view

No data available for mRNA differential expression in normal tissues for MAST4 Gene

Orthologs for MAST4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAST4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAST4 35
  • 99.22 (n)
  • 98.83 (a)
MAST4 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAST4 35
  • 84.35 (n)
  • 82.67 (a)
MAST4 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAST4 35
  • 86.7 (n)
  • 87.97 (a)
MAST4 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mast4 35
  • 81.94 (n)
  • 82.66 (a)
Mast4 16
Mast4 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAST4 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAST4 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mast4 35
  • 81.29 (n)
  • 82.1 (a)
chicken
(Gallus gallus)
Aves MAST4 35
  • 68.18 (n)
  • 69.38 (a)
MAST4 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAST4 36
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mast4 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6498 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea kin-4 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPK1 36
  • 24 (a)
ManyToMany
KIN82 36
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for MAST4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MAST4 Gene

ENSEMBL:
Gene Tree for MAST4 (if available)
TreeFam:
Gene Tree for MAST4 (if available)

Paralogs for MAST4 Gene

Paralogs for MAST4 Gene

genes like me logo Genes that share paralogs with MAST4: view

Variants for MAST4 Gene

Sequence variations from dbSNP and Humsavar for MAST4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs4102 -- 66,935,075(+) CAATC(C/T)GAGGC intron-variant
rs25832 -- 66,879,854(-) gttgt(C/T)ctaac intron-variant
rs25833 -- 66,879,347(-) tgtgt(A/G)tatat intron-variant
rs25834 -- 66,878,041(+) AAGTG(A/G)AAAAA intron-variant
rs25835 -- 66,877,990(-) GAAGC(A/T)ACTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAST4 Gene

Variant ID Type Subtype PubMed ID
esv34119 CNV Loss 18971310
nsv508365 CNV Loss 20534489
esv24501 CNV Loss 19812545
nsv881760 CNV Loss 21882294
esv2439275 CNV Deletion 19546169
esv2676830 CNV Deletion 23128226
nsv522181 CNV Loss 19592680
esv273910 CNV Insertion 20981092
esv268762 CNV Insertion 20981092
esv2676812 CNV Deletion 23128226
esv2656889 CNV Deletion 23128226
nsv516753 CNV Loss 19592680
esv2580346 CNV Deletion 19546169
esv2662343 CNV Deletion 23128226
esv2730281 CNV Deletion 23290073
nsv509970 CNV Loss 20534489
esv34053 CNV Loss 18971310
esv2496676 CNV Deletion 19546169
esv2079875 CNV Deletion 18987734
esv2662158 CNV Deletion 23128226
esv2028067 CNV Deletion 18987734
nsv507257 CNV Insertion 20534489
dgv6085n71 CNV Gain 21882294
esv2666110 CNV Deletion 23128226
dgv1803e1 CNV Complex 17122850

Relevant External Links for MAST4 Gene

HapMap Linkage Disequilibrium report
MAST4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAST4 Gene

Disorders for MAST4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MAST4 Gene including...

Search for MAST4 Gene in MalaCards »

(2) University of Copenhagen DISEASES for MAST4 Gene

Relevant External Links for MAST4

Genetic Association Database (GAD)
MAST4
Human Genome Epidemiology (HuGE) Navigator
MAST4
genes like me logo Genes that share disorders with MAST4: view

No data available for UniProtKB/Swiss-Prot for MAST4 Gene

Publications for MAST4 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Identification of a novel human MAST4 gene, a new member of the microtubule associated serine-threonine kinase family. (PMID: 17086981) Sun L. … Mao Y. (Mol. Biol. (Mosk.) 2006) 3 4
  4. A genome-wide association study of carotid atherosclerosis in HIV-infected men. (PMID: 20009918) Shrestha S. … Grunfeld C. (AIDS 2010) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for MAST4 Gene

Sources for MAST4 Gene

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