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MAST4 Gene

protein-coding   GIFtS: 58
GCID: GC05P065892

Microtubule Associated Serine/Threonine Kinase Family Member...

  See MAST4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microtubule Associated Serine/Threonine Kinase Family Member 41 2
EC 2.7.11.13 8
Microtubule-Associated Serine/Threonine-Protein Kinase 42
KIAA03033
EC 2.7.118

External Ids:    HGNC: 190371   Entrez Gene: 3754492   Ensembl: ENSG000000690207   UniProtKB: O150213   

Export aliases for MAST4 gene to outside databases

Previous GC identifers: GC05P066291 GC05P065929 GC05P062849


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAST4 Gene:
This gene encodes a member of the microtubule-associated serine/threonine protein kinases. The proteins in this
family contain a domain that gives the kinase the ability to determine its own scaffold to control the effects of
their kinase activities. Alternative splicing results in multiple transcript variants encoding different
isoforms. (provided by RefSeq, Mar 2014)

GeneCards Summary for MAST4 Gene:
MAST4 (microtubule associated serine/threonine kinase family member 4) is a protein-coding gene. Diseases associated with MAST4 include cystic lymphangioma. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is MAST2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAST4 gene promoter:
         HOXA9B   HOXA9   Pbx1a   FOXD3   Nkx2-5   NF-kappaB   LCR-F1   Meis-1b   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAST4 promoter sequence
   Search Chromatin IP Primers for MAST4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAST4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.3   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q12.3

MAST4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAST4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P065892:  view genomic region     (about GC identifiers)

Start:
65,892,176 bp from pter      End:
66,465,423 bp from pter
Size:
573,248 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MAST4_HUMAN, O15021 (See protein sequence)
Recommended Name: Microtubule-associated serine/threonine-protein kinase 4  
Size: 2626 amino acids; 284378 Da
Cofactor: Magnesium (By similarity)
1 PDB 3D structure from and Proteopedia for MAST4:
2W7R (3D)    
Secondary accessions: A6NL49 B5ME48 Q05EE6 Q6ZN07 Q8N4X4 Q96LY3
Alternative splicing: 5 isoforms:  O15021-5   O15021-2   O15021-4   O15021-1   O15021-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAST4: NX_O15021

Explore proteomics data for MAST4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAST4 (O15021) (see all 34)
     FFRSLDW  RPRSRSL  KLTDFGL  SYRSTPD 


    See MAST4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001158136.1  NP_001277155.1  NP_001277156.1  NP_001277157.1  NP_055998.1  NP_942123.1  

    ENSEMBL proteins: 
     ENSP00000385727   ENSP00000385088   ENSP00000384547   ENSP00000407977   ENSP00000413573  
     ENSP00000396765   ENSP00000398417   ENSP00000421739   ENSP00000384313   ENSP00000404801  
     ENSP00000384099   ENSP00000385260   ENSP00000413854   ENSP00000261569   ENSP00000392478  
     ENSP00000398694   ENSP00000400551   ENSP00000385048  

    MAST4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MAST4
    OriGene Protein Over-expression Lysate for MAST4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MAST4
    GenScript Custom Purified and Recombinant Proteins Services for MAST4
    Novus Biologicals MAST4 Proteins
    Novus Biologicals MAST4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAST4

     
    Search eBioscience for Proteins for MAST4 

    MAST4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for MAST4
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    Search ThermoFisher Antibodies for MAST4
    LSBio Antibodies in human, mouse, rat for MAST4

    MAST4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAST4
    Cloud-Clone Corp. CLIAs for MAST4
    Search eBioscience for ELISAs for MAST4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Microtubule associated serine/threonine kinase 4
    MAST family
    Other AGC kinases

    Selected InterPro protein domains (see all 8):
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR015022 MA_Ser/Thr_Kinase_dom
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry O15021

    ProtoNet protein and cluster: O15021

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: MAST4_HUMAN, O15021
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with MAST4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAST4_HUMAN, O15021
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
         
    Find genes that share ontologies with MAST4           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for MAST4:
     Cells with protrusions  Decreased Salmonella enterica   Decreased nuclei size in G2M  Decreased substrate adherent c 
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAST4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAST4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAST4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAST4

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAST4:
    hsa-mir-1 (MIRT024003), hsa-mir-324-3p (MIRT042944), hsa-mir-26b-5p (MIRT030238), hsa-mir-98-5p (MIRT027795)

    Block miRNA regulation of human, mouse, rat MAST4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAST4 (see all 69):
    hsa-miR-548j hsa-miR-128 hsa-miR-30d hsa-miR-877* hsa-miR-30a hsa-miR-548a-5p hsa-miR-92b hsa-miR-761
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MAST4
    Predesigned siRNA for gene silencing in human, mouse, rat MAST4

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MAST4

    Clone
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    OriGene clones in human, mouse for MAST4 (see all 15)
    OriGene ORF clones in mouse, rat for MAST4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MAST4 (NM_198828)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAST4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAST4
    Addgene plasmids for MAST4 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MAST4
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAST4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAST4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAST4_HUMAN, O15021: Cytoplasm (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with MAST4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAST4
    Interactions:

        Search GeneGlobe Interaction Network for MAST4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAST4 (O150212, 3 ENSP000003843134) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD1Q157972, 3MINT-62023 I2D: score=2 
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    CSNK2A1ENSP000002172444STRING: ENSP00000217244
    CSNK2A2ENSP000002625064STRING: ENSP00000262506
    KLF10ENSP000002854074STRING: ENSP00000285407
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    Find genes that share ontologies with MAST4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAST4

    2 HMDB Compounds for MAST4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAST4 gene (6 alternative transcripts): 
    NM_001164664.1  NM_001290226.1  NM_001290227.1  NM_001290228.1  NM_015183.2  NM_198828.2  

    Unigene Cluster for MAST4:

    Microtubule associated serine/threonine kinase family member 4
    Hs.595458  [show with all ESTs]
    Unigene Representative Sequence: NM_001164664
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000403625(uc003jut.2 uc003juw.3) ENST00000406374(uc010iwz.3 uc003jur.4)
    ENST00000406039 ENST00000478569 ENST00000452953 ENST00000432817 ENST00000451144
    ENST00000434115 ENST00000411628 ENST00000490016(uc003jus.3) ENST00000470421
    ENST00000403666 ENST00000450827 ENST00000405643(uc003juu.1 uc011cra.1)
    ENST00000407621 ENST00000432426 ENST00000261569(uc010ixa.2 uc003juv.2)
    ENST00000436277
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MAST4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAST4 (see all 69):
    hsa-miR-548j hsa-miR-128 hsa-miR-30d hsa-miR-877* hsa-miR-30a hsa-miR-548a-5p hsa-miR-92b hsa-miR-761
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MAST4
    Predesigned siRNA for gene silencing in human, mouse, rat MAST4
    Clone
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    OriGene clones in human, mouse for MAST4 (see all 15)
    OriGene ORF clones in mouse, rat for MAST4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MAST4 (NM_198828)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAST4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAST4
    Addgene plasmids for MAST4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAST4
    OriGene qSTAR qPCR primer pairs in human, mouse for MAST4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAST4
      QuantiTect SYBR Green Assays in human, mouse, rat MAST4
      QuantiFast Probe-based Assays in human, mouse, rat MAST4

    Additional mRNA sequence: 

    AB002301.1 AK057601.1 AK131421.1 AK296707.1 AK299538.1 AK299706.1 AK303578.1 AK309559.1 
    AY439222.1 AY830839.1 BC003646.2 BC018692.1 BC033215.1 BC068073.1 BC080587.1 BX648796.1 
    BX648980.1 

    18 DOTS entries:

    DT.452744  DT.91733520  DT.101975463  DT.97783724  DT.91733526  DT.101983320  DT.425215  DT.100693443 
    DT.120800341  DT.205206  DT.120800347  DT.91694369  DT.92405468  DT.91654527  DT.91805430  DT.97820106 
    DT.40267949  DT.91698962 

    1 AceView cDNA sequence:

    BG929085 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MAST4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                                                                                -                           
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                -                 -         
    SP4:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25 ^ 26
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        


    ECgene alternative splicing isoforms for MAST4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAST4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCGGGGCCA
    MAST4 Expression
    About this image


    MAST4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
     
     Thymus (Hematopoietic System)
             Thymus
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Neurons
             Glycinergic Amacrine Cells Inner Nuclear Layer
    MAST4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAST4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.595458

    UniProtKB/Swiss-Prot: MAST4_HUMAN, O15021
    Tissue specificity: Highly expressed in most normal human tissues, with an exception of in testis, small
    intestine, colon and peripheral blood leukocyte

        Custom PCR Arrays for MAST4
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    QuantiTect SYBR Green Assays in human, mouse, rat MAST4
    QuantiFast Probe-based Assays in human, mouse, rat MAST4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAST4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAST4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mast41 , 5 microtubule associated serine/threonine kinase family more1, 5 81.94(n)1
    82.66(a)1
      13 (54.94 cM)5
    3283291  NM_175171.31  NP_780380.21 
     1027324865 
    chicken
    (Gallus gallus)
    Aves MAST41 microtubule associated serine/threonine kinase family more 68.18(n)
    69.38(a)
      427169  XM_004937302.1  XP_004937359.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAST46
    microtubule associated serine/threonine kinase fam...
    63(a)
    1 ↔ 1
    2(11186512-11467206)
    zebrafish
    (Danio rerio)
    Actinopterygii mast46
    microtubule associated serine/threonine kinase fam...
    76(a)
    1 ↔ 1
    5(55521773-55566876) ENSDARG00000078270
    fruit fly
    (Drosophila melanogaster)
    Insecta CG64986
    --
    33(a)
    1 → many
    3L(15559113-15569413)
    worm
    (Caenorhabditis elegans)
    Secernentea kin-46
    Protein KIN-4, isoform g
    31(a)
    1 → many
    IV(11425742-11447065) WBGene00002192
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIN826
    FPK16
    Putative serine/threonine protein kinase implicate...
    Ser/Thr protein kinase that regulates the putative...
    26(a)
    24(a)
    many ↔ many
    many ↔ many
    III(274404-276566) YCR091W
    XIV(708523-711204) YNR047W


    ENSEMBL Gene Tree for MAST4 (if available)
    TreeFam Gene Tree for MAST4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAST4 gene
    MAST22  MAST32  MAST12  
    Selected SIMAP similar genes for MAST4 using alignment to 16 protein entries:     MAST4_HUMAN (see all proteins) (see all similar genes):
    MAST1    MAST3    RPS6KA1    RPS6KA5    SGK3    STK32A
    RPS6KA3    RPS6KA2    ARHGAP23    MAST2    PRKACB    KIN27
    PRKACA    MAP4K5    PRKY    AKT2    MAPK8    PRKACG

    Find genes that share paralogs with MAST4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAST4 (see all 11882)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0407914
    A lung squamous cell carcinoma sample4--see VAR_0407912 E D mis40--------
    rs715768731,2
    C--62888737(-) AAAAA-/A/    
       AAAAA
    CAGTC
    2 -- int11NA 2
    rs709871451,2
    C--63158095(-) TATCC-/CATTT 
            
    TTTTT
    3 -- int11Minor allele frequency- CATTT:0.00NA 2
    rs1807632631,2
    --65890241(+) TCAGGC/TGATAA 2 -- us2k10--------
    rs1502205231,2
    --65890249(+) TAATAA/GCTATT 2 -- us2k10--------
    rs1860204351,2
    --65890306(+) TCCCTA/GTGTAC 2 -- us2k10--------
    rs125231941,2
    C,H--65890344(+) TGTGCA/TTGGCT 2 -- us2k15Minor allele frequency- T:0.18WA NA EA 362
    rs68771761,2
    C,F,A,H--65890467(+) CCCACT/CGTGCT 2 -- us2k119Minor allele frequency- C:0.26NS EA NA WA CSA 2340
    rs1913438591,2
    --65890519(+) TTGACC/TTTTTG 2 -- us2k10--------
    rs1826676461,2
    --65890565(+) GAAGCA/GTCACA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAST4 (65892176 - 66142176 bp, first 250kb of MAST4)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAST4 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662343CNV Deletion23128226
    esv2676812CNV Deletion23128226
    esv2079875CNV Deletion18987734
    esv2662158CNV Deletion23128226
    esv2496676CNV Deletion19546169
    esv2676830CNV Deletion23128226
    esv2028067CNV Deletion18987734
    esv2730281CNV Deletion23290073
    esv2666110CNV Deletion23128226
    esv2439275CNV Deletion19546169

    Human Gene Mutation Database (HGMD): MAST4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAST4
    DNA2.0 Custom Variant and Variant Library Synthesis for MAST4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for MAST4:    
    About MalaCards
    cystic lymphangioma

    2 diseases from the University of Copenhagen DISEASES database for MAST4:
    Down syndrome     Cystic lymphangioma

    Find genes that share disorders with MAST4           About GenesLikeMe

    Genetic Association Database (GAD): MAST4
    Human Genome Epidemiology (HuGE) Navigator: MAST4 (1 document)

    Export disorders for MAST4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAST4 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with MAST4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. A genome-wide association study of carotid atherosclerosis in HIV-infected men. (PubMed id 20009918)1, 4 Shrestha S....Grunfeld C. (AIDS 2010)
    4. Identification of a novel human MAST4 gene, a new member of the microtubule associated serine-threonine kinase family. (PubMed id 17086981)1, 2 Sun L....Mao Y. (Mol. Biol. (Mosk.) 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32. (PubMed id 22949513)1  ....Sander T. (Hum. Mol. Genet. 2012)
    7. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)1 Martins-de-Souza D....Bahn S. (J. Proteome Res. 2012)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 375449 HGNC: 19037 AceView: LOC375449.1 Ensembl:ENSG00000069020 euGenes: HUgn375449
    ECgene: MAST4 H-InvDB: MAST4

    (According to HUGE)
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    HUGE: KIAA0303

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAST4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MAST4 gene:
    Search GeneIP for patents involving MAST4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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