Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MAST3 Gene

Aliases for MAST3 Gene

  • Microtubule Associated Serine/Threonine Kinase 3 2 3
  • EC 4 63
  • KIAA0561 4 6
  • EC 2.7.11 63

External Ids for MAST3 Gene

Previous GeneCards Identifiers for MAST3 Gene

  • GC19P018069
  • GC19P018208
  • GC19P017772

Summaries for MAST3 Gene

GeneCards Summary for MAST3 Gene

MAST3 (Microtubule Associated Serine/Threonine Kinase 3) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is MAST4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAST3 Gene

Genomics for MAST3 Gene

Regulatory Elements for MAST3 Gene

Genomic Location for MAST3 Gene

18,097,775 bp from pter
18,151,692 bp from pter
53,918 bases
Plus strand

Genomic View for MAST3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAST3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAST3 Gene

Proteins for MAST3 Gene

  • Protein details for MAST3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Microtubule-associated serine/threonine-protein kinase 3
    Protein Accession:
    Secondary Accessions:
    • Q7LDZ8
    • Q9UPI0

    Protein attributes for MAST3 Gene

    1309 amino acids
    Molecular mass:
    143137 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PTEN.
    • Sequence=AAC62830.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAST3 Gene

neXtProt entry for MAST3 Gene

Proteomics data for MAST3 Gene at MOPED

Post-translational modifications for MAST3 Gene

  • Ubiquitination at Lys652
  • Modification sites at PhosphoSitePlus

Other Protein References for MAST3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for MAST3 Gene

Suggested Antigen Peptide Sequences for MAST3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MAST3: view

Function for MAST3 Gene

Molecular function for MAST3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for MAST3 Gene

Gene Ontology (GO) - Molecular Function for MAST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 15951562
genes like me logo Genes that share ontologies with MAST3: view
genes like me logo Genes that share phenotypes with MAST3: view

Animal Model Products

miRNA for MAST3 Gene

miRTarBase miRNAs that target MAST3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAST3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for MAST3 Gene

Localization for MAST3 Gene

Subcellular locations from

Jensen Localization Image for MAST3 Gene COMPARTMENTS Subcellular localization image for MAST3 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAST3 Gene

Pathways for MAST3 Gene

SuperPathways for MAST3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with MAST3: view

No data available for Pathways by source for MAST3 Gene

Drugs for MAST3 Gene

(3) HMDB Compounds for MAST3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • Adenosindiphosphorsaeure
  • Magnesium
genes like me logo Genes that share compounds with MAST3: view

Transcripts for MAST3 Gene

Unigene Clusters for MAST3 Gene

Microtubule associated serine/threonine kinase 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAST3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAST3 Gene

No ASD Table

Relevant External Links for MAST3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAST3 Gene

mRNA expression in normal human tissues for MAST3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAST3 Gene

This gene is overexpressed in Whole Blood (6.4) and Brain - Cortex (4.9).

Protein differential expression in normal tissues for MAST3 Gene

This gene is overexpressed in Saliva (25.1), Blymphocyte (12.9), and Peripheral blood mononuclear cells (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAST3 Gene

SOURCE GeneReport for Unigene cluster for MAST3 Gene Hs.466184

genes like me logo Genes that share expressions with MAST3: view

Expression partners for MAST3 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MAST3 Gene

Orthologs for MAST3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAST3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MAST3 35
  • 86.64 (n)
  • 92.14 (a)
MAST3 36
  • 91 (a)
(Canis familiaris)
Mammalia MAST3 35
  • 88.26 (n)
  • 94.15 (a)
MAST3 36
  • 92 (a)
(Mus musculus)
Mammalia Mast3 35
  • 82.41 (n)
  • 89.77 (a)
Mast3 16
Mast3 36
  • 89 (a)
(Pan troglodytes)
Mammalia MAST3 35
  • 97.35 (n)
  • 96.71 (a)
MAST3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mast3 35
  • 82.42 (n)
  • 89.77 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
-- 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia MAST3 36
  • 79 (a)
(Gallus gallus)
Aves MAST3 35
  • 75.18 (n)
  • 77.98 (a)
MAST3 36
  • 69 (a)
(Anolis carolinensis)
Reptilia MAST3 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mast3 35
  • 69 (n)
  • 77.04 (a)
(Danio rerio)
Actinopterygii LOC100535762 35
  • 66.48 (n)
  • 70.66 (a)
BX004890.2 36
  • 61 (a)
MAST3 (1 of 2) 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6498 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea kin-4 36
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPK1 36
  • 23 (a)
KIN82 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
Species with no ortholog for MAST3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAST3 Gene

Gene Tree for MAST3 (if available)
Gene Tree for MAST3 (if available)

Paralogs for MAST3 Gene

Paralogs for MAST3 Gene

(18) SIMAP similar genes for MAST3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MAST3: view

Variants for MAST3 Gene

Sequence variations from dbSNP and Humsavar for MAST3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs82554 -- 18,122,799(+) GGTTG(G/T)GGGGG intron-variant
rs82555 -- 18,122,849(+) TGTGC(A/G)GTCAG intron-variant
rs123201 -- 18,123,809(+) CCTGC(A/G)CCAGC intron-variant
rs123202 -- 18,124,542(+) CCCAG(G/T)GGGTG intron-variant
rs123203 -- 18,124,614(+) AGCCC(C/T)GGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAST3 Gene

Variant ID Type Subtype PubMed ID
nsv470130 CNV Loss 18288195
nsv833773 CNV Loss 17160897
dgv3771n71 CNV Loss 21882294
dgv3772n71 CNV Loss 21882294
nsv911244 CNV Gain 21882294
dgv3773n71 CNV Loss 21882294
nsv833774 CNV Loss 17160897
nsv833775 CNV Loss 17160897
dgv3774n71 CNV Loss 21882294
nsv2429 CNV Loss 18451855
esv2718285 CNV Deletion 23290073
esv2658066 CNV Deletion 23128226
nsv911254 CNV Loss 21882294
dgv3775n71 CNV Loss 21882294
nsv911256 CNV Loss 21882294
dgv3776n71 CNV Loss 21882294

Relevant External Links for MAST3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAST3 Gene

Disorders for MAST3 Gene

No disorders were found for MAST3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MAST3 Gene

Publications for MAST3 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  2. Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. (PMID: 15951562) Valiente M. … Pulido R. (J. Biol. Chem. 2005) 3 4
  3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  4. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3
  5. Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. (PMID: 12421765) Nakayama M. … Ohara O. (Genome Res. 2002) 3

Products for MAST3 Gene

Sources for MAST3 Gene

Back to Top