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MAST3 Gene

protein-coding   GIFtS: 50
GCID: GC19P018208

Microtubule Associated Serine/Threonine Kinase 3

  Search for MAST3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microtubule Associated Serine/Threonine Kinase 31 2
EC 2.7.11.13 8
KIAA05613 5
Microtubule-Associated Serine/Threonine-Protein Kinase 32
EC 2.7.118

External Ids:    HGNC: 190361   Entrez Gene: 230312   Ensembl: ENSG000000993087   OMIM: 6122585   UniProtKB: O603073   

Export aliases for MAST3 gene to outside databases

Previous GC identifers: GC19P018069 GC19P017772


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MAST3 Gene:
MAST3 (microtubule associated serine/threonine kinase 3) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is MAST2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAST3 gene promoter:
         Bach1   STAT1   STAT5A   XBP-1   HEN1   HSF2   STAT3   ATF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MAST3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAST3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13

MAST3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAST3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P018208:  view genomic region     (about GC identifiers)

Start:
18,208,603 bp from pter      End:
18,262,502 bp from pter
Size:
53,900 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MAST3_HUMAN, O60307 (See protein sequence)
Recommended Name: Microtubule-associated serine/threonine-protein kinase 3  
Size: 1309 amino acids; 143137 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with PTEN
Caution: It is uncertain whether Met-1, Met-171 or Met-172 is the initiator
Sequence caution: Sequence=AAC62830.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for MAST3:
1V9V (3D)        3KHF (3D)    
Secondary accessions: Q7LDZ8 Q9UPI0

Explore the universe of human proteins at neXtProt for MAST3: NX_O60307

Explore proteomics data for MAST3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys652
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAST3 (O60307) (see all 27)
     RSLSPGR  GHIKLTD  MFCSFET  RPRSRSL 


    See MAST3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055831.1  
    ENSEMBL proteins: 
     ENSP00000262811   ENSP00000477109  

    MAST3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
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    GenScript Custom Purified and Recombinant Proteins Services for MAST3
    Novus Biologicals MAST3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAST3

    MAST3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MAST3
    OriGene Custom Antibody Services for MAST3
    Novus Biologicals MAST3 Antibodies
    Search for Antibodies for MAST3 at Abcam
    Cloud-Clone Corp. Antibodies for MAST3
    Search ThermoFisher Antibodies for MAST3
    LSBio Antibodies in human, mouse, rat for MAST3

    MAST3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAST3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAST3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAST3
    Cloud-Clone Corp. CLIAs for MAST3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Microtubule associated serine/threonine kinase 3
    MAST family
    Other AGC kinases

    Selected InterPro protein domains (see all 8):
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR015022 MA_Ser/Thr_Kinase_dom
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry O60307

    ProtoNet protein and cluster: O60307

    2 Blocks protein domains:
    IPB000961 Protein kinase C-terminal domain
    IPB001478 PDZ/DHR/GLGF domain


    UniProtKB/Swiss-Prot: MAST3_HUMAN, O60307
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 protein kinase domain


    MAST3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAST3_HUMAN, O60307
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI15951562
         
    MAST3 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for MAST3:
     Decreased BPV1 E2 protein expr  Decreased mitotic index  Increased HPV18 LCR reporter a  Increased cell death HMECs cel 
     Increased colony dispersion (i  Paclitaxel antagonistic effect 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAST3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAST3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAST3

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAST3:
    hsa-mir-484 (MIRT042385)

    Block miRNA regulation of human, mouse, rat MAST3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAST3 (see all 39):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-106a hsa-miR-30d hsa-miR-759 hsa-miR-30a hsa-miR-93 hsa-miR-520g
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAST3
    Predesigned siRNA for gene silencing in human, mouse, rat MAST3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAST3

    Clone
    Products:
         
    OriGene clones in human, mouse for MAST3 (see all 8)
    OriGene ORF clones in mouse, rat for MAST3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAST3 (NM_015016)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAST3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAST3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MAST3
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAST3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAST3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1
    mitochondrion1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAST3
    Interactions:

        GeneGlobe Interaction Network for MAST3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAST3 (O603071, 3 ENSP000002628114) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTENP604841, 3, ENSP000003610214EBI-311420,EBI-696162 I2D: score=3 STRING: ENSP00000361021
    PRKAB2O437413, ENSP000002541014I2D: score=3 STRING: ENSP00000254101
    PRKAA2P546463, ENSP000003602904I2D: score=3 STRING: ENSP00000360290
    CNTNAP4Q9C0A03, ENSP000004176284I2D: score=1 STRING: ENSP00000417628
    YWHAHQ049173, ENSP000002489754I2D: score=1 STRING: ENSP00000248975
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    MAST3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAST3

    3 HMDB Compounds for MAST3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAST3 gene: 
    NM_015016.1  

    Unigene Cluster for MAST3:

    Microtubule associated serine/threonine kinase 3
    Hs.466184  [show with all ESTs]
    Unigene Representative Sequence: NM_015016
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262811(uc002nhz.4) ENST00000608648 ENST00000601226 ENST00000609494
    ENST00000609076
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MAST3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAST3 (see all 39):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-106a hsa-miR-30d hsa-miR-759 hsa-miR-30a hsa-miR-93 hsa-miR-520g
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MAST3
    Predesigned siRNA for gene silencing in human, mouse, rat MAST3
    Clone
    Products:
         
    OriGene clones in human, mouse for MAST3 (see all 8)
    OriGene ORF clones in mouse, rat for MAST3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAST3 (NM_015016)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAST3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAST3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MAST3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAST3
      QuantiTect SYBR Green Assays in human, mouse, rat MAST3
      QuantiFast Probe-based Assays in human, mouse, rat MAST3

    Additional mRNA sequence: AB011133.1 

    5 DOTS entries:

    DT.95369402  DT.92419725  DT.95369403  DT.414154  DT.92419722 

    Selected AceView cDNA sequences (see all 121):

    BM692853 BU428696 BM766477 AW015938 CB156677 BF740251 AA662737 BM463652 
    BM671428 BQ775218 AA633262 BM823292 CA308743 AA576023 BX956138 CB146127 
    T33494 AB011133 Z39983 AW071776 BM893556 BX109029 CB134352 BM966751 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAST3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTCACCCCC
    MAST3 Expression
    About this image


    MAST3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Pons
    MAST3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAST3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466184
        Custom PCR Arrays for MAST3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MAST3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAST3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAST3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mast31 , 5 microtubule associated serine/threonine kinase 31, 5 82.41(n)1
    89.77(a)1
      8 (34.15 cM)5
    5460711  NM_199308.21  NP_955012.21 
     707781175 
    chicken
    (Gallus gallus)
    Aves MAST31 microtubule associated serine/threonine kinase 3 75.18(n)
    77.98(a)
      420130  XM_418247.4  XP_418247.3 
    lizard
    (Anolis carolinensis)
    Reptilia MAST36
    microtubule associated serine/threonine kinase 3
    70(a)
    1 ↔ 1
    GL344274.1(13468-46215)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ617163.12   -- 76.99(n)    BJ617163.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005357621 microtubule-associated serine/threonine-protein kinase more 66.48(n)
    70.66(a)
      100535762  XM_003199469.2  XP_003199517.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG64986
    --
    28(a)
    1 → many
    3L(15559113-15569413)
    worm
    (Caenorhabditis elegans)
    Secernentea kin-46
    Protein KIN-4, isoform g
    29(a)
    1 → many
    IV(11425742-11447065) WBGene00002192
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIN826
    FPK16
    Putative serine/threonine protein kinase implicate...
    Ser/Thr protein kinase that regulates the putative...
    26(a)
    23(a)
    many ↔ many
    many ↔ many
    III(274404-276566) YCR091W
    XIV(708523-711204) YNR047W
    rice
    (Oryza sativa)
    Liliopsida AK062282.12   -- 73.65(n)    AK062282.1 


    ENSEMBL Gene Tree for MAST3 (if available)
    TreeFam Gene Tree for MAST3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAST3 gene
    MAST22  MAST12  MAST42  
    18 SIMAP similar genes for MAST3 using alignment to 2 protein entries:     MAST3_HUMAN (see all proteins):
    MAST1    MAST4    MAST2    PRKACA    STK38L    ARHGAP23
    PRKACB    PRKACG    PRKY    STK38    AKT3    SGK2
    PRKX    RPS6KB1    SGK1    AKT2    PRKAA1    TSSK3

    MAST3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAST3 (see all 1256)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1451697591,2
    C--18206633(+) TCCTA-/GGGGTC 1 -- us2k10--------
    rs4261321,2
    C,F,H--18206681(+) TACAGT/CGGGGC 1 -- us2k118Minor allele frequency- C:0.21NS EA NA WA CSA 2073
    rs776994131,2
    F--18206703(+) ACTGCG/AGCTGC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1415116001,2
    --18206745(+) ATGCAA/GGTGCT 1 -- us2k10--------
    rs1155672761,2
    F--18206968(+) GATCGC/TTTGAG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1462211471,2
    --18206979(+) CCCGGA/GAGGTA 1 -- us2k10--------
    rs746610111,2
    C--18207062(+) AAAAAA/TTTTTT 1 -- us2k10--------
    rs745588711,2
    C,F--18207206(+) CAATCA/GTCCTC 1 -- us2k13Minor allele frequency- G:0.16WA CSA 122
    rs347031871,2
    C--18207211(+) AAAAA-/AGAAAC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs557145391,2
    C,F--18207397(+) CCCAGA/CACTTT 1 -- us2k18Minor allele frequency- C:0.33NA WA CSA EA 368

    HapMap Linkage Disequilibrium report for MAST3 (18208603 - 18262502 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAST3 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658066CNV Deletion23128226
    esv2718285CNV Deletion23290073
    nsv911254CNV Loss21882294
    dgv3773n71CNV Loss21882294
    dgv3772n71CNV Loss21882294
    nsv2429CNV Loss18451855
    dgv3774n71CNV Loss21882294
    dgv3775n71CNV Loss21882294
    nsv911256CNV Loss21882294
    nsv833773CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAST3
    DNA2.0 Custom Variant and Variant Library Synthesis for MAST3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612258    OMIM disorders: --


    MAST3 for disorders           About GeneDecksing


    Export disorders for MAST3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAST3 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with MAST3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. (PubMed id 15951562)1, 2 Valiente M.... Pulido R. (J. Biol. Chem. 2005)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (DNA Res. 1998)
    4. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (Nature 2010)
    5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    6. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (Mol. Cell. Proteomics 2009)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    8. MAST3: a novel IBD risk factor that modulates TLR4 signaling. (PubMed id 18650832)1 LabbAc C....Rioux J.D. (Genes Immun. 2008)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23031 HGNC: 19036 AceView: MAST3 Ensembl:ENSG00000099308 euGenes: HUgn23031
    ECgene: MAST3 H-InvDB: MAST3

    (According to HUGE)
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    HUGE: KIAA0561

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAST3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAST3 gene:
    Search GeneIP for patents involving MAST3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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