MAST3 Gene
protein-coding GIFtS: 47
GCID: GC19P018208
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|
microtubule associated serine/threonine kinase 3
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Aliases
for MAST3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Microtubule Associated Serine/Threonine Kinase 31 2 | | KIAA05611 3 5 | | EC 2.7.11.13 8 | | Microtubule-Associated Serine/Threonine-Protein Kinase 32 | | EC 2.7.118 |
Export aliases for MAST3 gene to outside databasesPrevious GC identifers: GC19P018069 GC19P017772 |
Summaries
for MAST3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for MAST3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAST3 gene promoter:
Bach1 STAT1 STAT5A XBP-1 HEN1 HSF2 STAT3 ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAST3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAST3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13MAST3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P018208: view genomic region
(about GC identifiers)
Start:
|
18,208,603 bp from pter |
End:
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18,262,499 bp from pter |
Size:
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53,897 bases |
Orientation:
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plus strand |
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Proteins
for MAST3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAST3_HUMAN, O60307 (See
protein sequence)Recommended Name: Microtubule-associated serine/threonine-protein kinase 3 Size: 1309 amino acids; 143137 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with PTEN
Caution: It is uncertain whether Met-1, Met-171 or Met-172 is the initiator
Sequence caution: Sequence=AAC62830.1; Type=Erroneous initiation;
2 PDB 3D structures from  and Proteopedia  for MAST3:1V9V (3D)
3KHF (3D)
Secondary accessions: Q7LDZ8 Q9UPI0Explore the universe of human proteins at neXtProt for MAST3: NX_O60307
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60307
4/27 DME Specific Peptides for MAST3 (O60307) (see all 27)
MAST3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055831.1
ENSEMBL proteins: ENSP00000262811
Human Recombinant Protein Products:
MAST3 Antibody Products:
Assay Products for MAST3: |
Protein
Domains /
Families
for MAST3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAST3 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry O60307ProtoNet protein and cluster: O60307 2 Blocks protein families: IPB000961 Protein kinase C-terminal domain IPB001478 PDZ/DHR/GLGF domain
UniProtKB/Swiss-Prot: MAST3_HUMAN, O60307Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase familySimilarity: Contains 1 AGC-kinase C-terminal domainSimilarity: Contains 1 PDZ (DHR) domainSimilarity: Contains 1 protein kinase domain |
Function
for MAST3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MAST3_HUMAN, O60307Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAST3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAST3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MAST3 (NM_015016) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAST3 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAST3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAST3 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
MAST3 for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for MAST3:
|
Pathways & Interactions
for MAST3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAST3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/7 Interacting proteins for MAST3 (O603071, 3 ENSP000002628114) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
|
Drugs & Compounds
for MAST3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAST3
3 HMDB Compounds for MAST3 About this table
Search CenterWatch for drugs/clinical trials and news about MAST3
|
Transcripts
for MAST3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAST3 gene: NM_015016.1 Unigene Cluster for MAST3: Microtubule associated serine/threonine kinase 3 Hs.466184 [show with all ESTs]Unigene Representative Sequence: NM_0150161 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000262811(uc002nhz.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAST3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAST3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MAST3 (NM_015016) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAST3 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAST3 |
Additional cDNA sequence: AB011133.1 5 DOTS entries: DT.95369402 DT.92419725 DT.95369403 DT.414154 DT.92419722 24/121 AceView cDNA sequences (see all 121): AW015938 AA662737 CB156677 BM823292 AA576023 BX956138 BU428696 BM893556 BG149225 Z39983 CB146127 BM692853 BQ775218 BX109029 AW071776 CB134352 BM766477 BM463652 T33494 BM671428 AA633262 AB011133 BM966751 AI359959
GeneLoc Exon Structure
|
Expression
for MAST3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAST3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTCACCCCC
About this image
See MAST3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAST3
SOURCE GeneReport for Unigene cluster: Hs.466184
SABiosciences Custom PCR Arrays for MAST3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAST3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAST3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAST3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAST3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAST3 |
Orthologs
for MAST3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MAST3 gene from 7/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MAST31 |
microtubule associated serine/threonine kinase 3 |
75.73(n)
79.21(a) |
|
420130 XM_418247.3 XP_418247.3 |
lizard
(Anolis carolinensis) |
Reptilia |
MAST36 |
-- |
72(a) |
1 ↔ 1 |
GL344274.1(13462-46215) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ617163.12 |
-- |
76.99(n) |
|
BJ617163.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1005357621 |
microtubule-associated serine/threonine-protein kinase more |
67.16(n)
71.81(a) |
|
100535762 XM_003199469.1 XP_003199517.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG64986 |
-- |
26(a) |
possible ortholog |
3L(15559113-15569413) |
worm
(Caenorhabditis elegans) |
Secernentea |
kin-46 |
protein KINase family member (kin-4) |
27(a) |
1 → many |
IV(11425720-11447043) |
rice
(Oryza sativa) |
Liliopsida |
AK062282.12 |
-- |
73.65(n) |
|
AK062282.1 |
ENSEMBL Gene Tree for MAST3 (if available)
TreeFam Gene Tree for MAST3 (if available) |
Paralogs
for MAST3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAST3 gene
- MAST22 MAST12 MAST42
18/19 SIMAP similar genes for MAST3 using alignment to 1 protein entry: MAST3_HUMAN(see all similar genes):MAST1 MAST4 MAST2 PRKACA STK38L ARHGAP23
PRKACB PRKACG PRKY STK38 AKT3 SGK2
PRKX RPS6KB1 SGK1 AKT2 PRKAA1 TSSK3
MAST3 for paralogs About GeneDecksing
|
Genomic Variants
for MAST3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAST3 (18208603 - 18262499 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MAST3
2 CNVs: 5093 5092 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAST3 |
|
Disorders
/ Diseases
for MAST3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MAST3 for disorders About MalaCards
MAST3 for disorders About GeneDecksing
OMIM gene information: 612258
OMIM disorders: --
Export disorders for MAST3 gene to outside databases
|
Publications
for MAST3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAST3 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with MAST3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. (PubMed id 15951562)1, 2 Valiente M.... Pulido R. (2005)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (1998)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
- Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- MAST3: a novel IBD risk factor that modulates TLR4 si gnaling. (PubMed id 18650832)1 LabbAc C....Rioux J.D. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for MAST3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAST3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAST3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing MAST3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MAST3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MAST3 gene:
Search GeneIP for patents involving MAST3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAST3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MAST3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAST3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAST3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAST3 | | OriGene 3'-UTR Clone for MAST3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAST3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAST3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MAST3 | | OriGene Custom Protein Services for MAST3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAST3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAST3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAST3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAST3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAST3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAST3 |
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 |  |  |  | |
| | | | Search Tocris compounds for MAST3 |
| |  |  |  |  | | | | |
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 | | | MAST3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAST3 |
|  |  |  | | | | Search ThermoFisher Antibodies for MAST3 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAST3 |
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