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Aliases for MAST3 Gene

Aliases for MAST3 Gene

  • Microtubule Associated Serine/Threonine Kinase 3 2 3 5
  • EC 2.7.11.1 4 63
  • EC 2.7.11 63
  • KIAA0561 4

External Ids for MAST3 Gene

Previous GeneCards Identifiers for MAST3 Gene

  • GC19P018069
  • GC19P018208
  • GC19P017772
  • GC19P018137
  • GC19P018196

Summaries for MAST3 Gene

GeneCards Summary for MAST3 Gene

MAST3 (Microtubule Associated Serine/Threonine Kinase 3) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAST4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAST3 Gene

Genomics for MAST3 Gene

Regulatory Elements for MAST3 Gene

Enhancers for MAST3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAST3 on UCSC Golden Path with GeneCards custom track

Promoters for MAST3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAST3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAST3 Gene

Chromosome:
19
Start:
18,097,764 bp from pter
End:
18,151,692 bp from pter
Size:
53,929 bases
Orientation:
Plus strand

Genomic View for MAST3 Gene

Genes around MAST3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAST3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAST3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAST3 Gene

Proteins for MAST3 Gene

  • Protein details for MAST3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60307-MAST3_HUMAN
    Recommended name:
    Microtubule-associated serine/threonine-protein kinase 3
    Protein Accession:
    O60307
    Secondary Accessions:
    • Q7LDZ8
    • Q9UPI0

    Protein attributes for MAST3 Gene

    Size:
    1309 amino acids
    Molecular mass:
    143137 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PTEN.
    SequenceCaution:
    • Sequence=AAC62830.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAST3 Gene

neXtProt entry for MAST3 Gene

Proteomics data for MAST3 Gene at MOPED

Post-translational modifications for MAST3 Gene

  • Ubiquitination at Lys 652
  • Modification sites at PhosphoSitePlus

Other Protein References for MAST3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MAST3 Gene

Suggested Antigen Peptide Sequences for MAST3 Gene

Graphical View of Domain Structure for InterPro Entry

O60307

UniProtKB/Swiss-Prot:

MAST3_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MAST3: view

Function for MAST3 Gene

Molecular function for MAST3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for MAST3 Gene

Gene Ontology (GO) - Molecular Function for MAST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MAST3: view
genes like me logo Genes that share phenotypes with MAST3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MAST3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAST3 Gene

Localization for MAST3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAST3 Gene COMPARTMENTS Subcellular localization image for MAST3 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 1
extracellular 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAST3 Gene

Pathways & Interactions for MAST3 Gene

SuperPathways for MAST3 Gene

No Data Available

SIGNOR curated interactions for MAST3 Gene

Activates:
Other effect:

Gene Ontology (GO) - Biological Process for MAST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with MAST3: view

No data available for Pathways by source for MAST3 Gene

Drugs & Compounds for MAST3 Gene

(2) Drugs for MAST3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for MAST3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MAST3: view

Transcripts for MAST3 Gene

Unigene Clusters for MAST3 Gene

Microtubule associated serine/threonine kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAST3 Gene

No ASD Table

Relevant External Links for MAST3 Gene

GeneLoc Exon Structure for
MAST3
ECgene alternative splicing isoforms for
MAST3

Expression for MAST3 Gene

mRNA expression in normal human tissues for MAST3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAST3 Gene

This gene is overexpressed in Whole Blood (x6.4) and Brain - Cortex (x4.9).

Protein differential expression in normal tissues from HIPED for MAST3 Gene

This gene is overexpressed in Saliva (25.1), Blymphocyte (12.9), and Peripheral blood mononuclear cells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAST3 Gene



SOURCE GeneReport for Unigene cluster for MAST3 Gene Hs.466184

genes like me logo Genes that share expression patterns with MAST3: view

Protein tissue co-expression partners for MAST3 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MAST3 Gene

Orthologs for MAST3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAST3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAST3 35
  • 86.64 (n)
  • 92.14 (a)
MAST3 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAST3 35
  • 88.26 (n)
  • 94.15 (a)
MAST3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mast3 35
  • 82.41 (n)
  • 89.77 (a)
Mast3 16
Mast3 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAST3 35
  • 97.35 (n)
  • 96.71 (a)
MAST3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mast3 35
  • 82.42 (n)
  • 89.77 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MAST3 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAST3 35
  • 75.18 (n)
  • 77.98 (a)
MAST3 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAST3 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mast3 35
  • 69 (n)
  • 77.04 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100535762 35
  • 66.48 (n)
  • 70.66 (a)
BX004890.2 36
  • 61 (a)
OneToMany
MAST3 (1 of 2) 36
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6498 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea kin-4 36
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPK1 36
  • 23 (a)
ManyToMany
KIN82 36
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for MAST3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAST3 Gene

ENSEMBL:
Gene Tree for MAST3 (if available)
TreeFam:
Gene Tree for MAST3 (if available)

Paralogs for MAST3 Gene

Paralogs for MAST3 Gene

(18) SIMAP similar genes for MAST3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MAST3: view

Variants for MAST3 Gene

Sequence variations from dbSNP and Humsavar for MAST3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_040786 -
rs35945810 - 18,124,000(+) CGCCC(A/G)GCTGG reference, missense
rs8108738 - 18,144,549(+) ATGCC(A/G)GCCGG reference, missense
rs12978339 -- 18,120,571(+) CACTC(A/G)TGTCG intron-variant
rs12978981 -- 18,104,457(+) CGACC(C/T)TTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAST3 Gene

Variant ID Type Subtype PubMed ID
nsv470130 CNV Loss 18288195
nsv833773 CNV Loss 17160897
dgv3771n71 CNV Loss 21882294
dgv3772n71 CNV Loss 21882294
nsv911244 CNV Gain 21882294
dgv3773n71 CNV Loss 21882294
nsv833774 CNV Loss 17160897
nsv833775 CNV Loss 17160897
dgv3774n71 CNV Loss 21882294
nsv2429 CNV Loss 18451855
esv2718285 CNV Deletion 23290073
esv2658066 CNV Deletion 23128226
nsv911254 CNV Loss 21882294
dgv3775n71 CNV Loss 21882294
nsv911256 CNV Loss 21882294
dgv3776n71 CNV Loss 21882294

Variation tolerance for MAST3 Gene

Residual Variation Intolerance Score: 4.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.65; 65.72% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MAST3 Gene

Disorders for MAST3 Gene

Relevant External Links for MAST3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAST3

No disorders were found for MAST3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAST3 Gene

Publications for MAST3 Gene

  1. Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. (PMID: 15951562) Valiente M. … Pulido R. (J. Biol. Chem. 2005) 3 4 67
  2. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  3. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for MAST3 Gene

Sources for MAST3 Gene

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