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Aliases for MAST3 Gene

Aliases for MAST3 Gene

  • Microtubule Associated Serine/Threonine Kinase 3 2 3 5
  • EC 2.7.11.1 4 61
  • EC 2.7.11 61
  • KIAA0561 4

External Ids for MAST3 Gene

Previous GeneCards Identifiers for MAST3 Gene

  • GC19P018069
  • GC19P018208
  • GC19P017772
  • GC19P018137
  • GC19P018196
  • GC19P018364
  • GC19P018384
  • GC19P018716

Summaries for MAST3 Gene

GeneCards Summary for MAST3 Gene

MAST3 (Microtubule Associated Serine/Threonine Kinase 3) is a Protein Coding gene. Diseases associated with MAST3 include Inflammatory Bowel Disease 6. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAST2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAST3 Gene

Genomics for MAST3 Gene

Regulatory Elements for MAST3 Gene

Enhancers for MAST3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G018086 1.7 FANTOM5 ENCODE dbSUPER 6.5 -8.4 -8449 5.9 HDGF PKNOX1 ZFP64 ARID4B ZNF766 ZNF207 ZNF263 JUNB REST TBX21 IL12RB1 ENSG00000268030 UPF1 FKBP8 ENSG00000268938 ELL ENSG00000269191 ENSG00000269815 ENSG00000269439 FCHO1
GH19G018107 1.3 ENCODE dbSUPER 6.1 +11.6 11599 4.2 ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF121 GLIS2 ZNF143 PDE4C MAST3 KIAA1683 PIR61285 IL12RB1
GH19G018057 1.5 Ensembl ENCODE dbSUPER 5.2 -39.4 -39431 1.5 HDGF ARID4B ZNF2 ZNF48 ZBTB7B ZNF766 GLIS2 ZNF207 ZNF143 KLF7 KIAA1683 MAST3 RPS18P13
GH19G017845 1.3 FANTOM5 ENCODE 5.5 -248.9 -248889 6.2 HDGF PKNOX1 WRNIP1 ARID4B DMAP1 ZBTB7B SLC30A9 GTF3C2 ELK1 ZNF207 UPF1 ENSG00000268030 FCHO1 JAK3 B3GNT3 INSL3 MVB12A UNC13A ENSG00000268938 RPL18A
GH19G018082 1 dbSUPER 5.2 -15.1 -15136 0.7 HDGF PKNOX1 ATF1 AGO1 ARID4B SIN3A ZNF48 ZNF2 YY1 TCF12 IL12RB1 MAST3 RPS18P13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAST3 on UCSC Golden Path with GeneCards custom track

Promoters for MAST3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108010 36 401 HDGF PKNOX1 ARNT WRNIP1 SIN3A ZNF2 ZNF143 REST GLIS1 RCOR2

Genomic Location for MAST3 Gene

Chromosome:
19
Start:
18,097,764 bp from pter
End:
18,151,692 bp from pter
Size:
53,929 bases
Orientation:
Plus strand

Genomic View for MAST3 Gene

Genes around MAST3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAST3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAST3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAST3 Gene

Proteins for MAST3 Gene

  • Protein details for MAST3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60307-MAST3_HUMAN
    Recommended name:
    Microtubule-associated serine/threonine-protein kinase 3
    Protein Accession:
    O60307
    Secondary Accessions:
    • Q7LDZ8
    • Q9UPI0

    Protein attributes for MAST3 Gene

    Size:
    1309 amino acids
    Molecular mass:
    143137 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PTEN.
    SequenceCaution:
    • Sequence=AAC62830.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAST3 Gene

neXtProt entry for MAST3 Gene

Selected DME Specific Peptides for MAST3 Gene

O60307:
  • RFSKVYSS
  • MFCSFET
  • AETVLALEYLH
  • LYEFLVGCVPFFGDTPEELFGQV
  • LTDFGLSK
  • RPRSRSL
  • CSFETRRHLCMVMEYVEGGDCATL
  • CGTPEYIAPE
  • KLTDFGL
  • TIKLISNGAYGAVYLVRHRDTRQRFA
  • ELARDCL
  • SSTLSSSSS
  • ESDFETIKLISNGAYGAVY
  • DNEIVMMNHVY
  • DELHFLSKHF
  • RSLSPGR
  • GHIKLTD
  • GKPVDWWA
  • RPARLLECLEF
  • GHIKLTDFGLSK
  • KELSLPRRG
  • IKLTDFG
  • WPEGDEALP
  • GIVHRDLKPDN
  • FVERDILTFAENPFVV
  • VHRDLKP
  • IVHRDLK

Post-translational modifications for MAST3 Gene

  • Ubiquitination at Lys652
  • Modification sites at PhosphoSitePlus

Domains & Families for MAST3 Gene

Suggested Antigen Peptide Sequences for MAST3 Gene

Graphical View of Domain Structure for InterPro Entry

O60307

UniProtKB/Swiss-Prot:

MAST3_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MAST3: view

Function for MAST3 Gene

Molecular function for MAST3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for MAST3 Gene

Gene Ontology (GO) - Molecular Function for MAST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005515 protein binding IPI 15951562
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MAST3: view
genes like me logo Genes that share phenotypes with MAST3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MAST3

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAST3 Gene

Localization for MAST3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAST3 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
genes like me logo Genes that share ontologies with MAST3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAST3 Gene

Pathways & Interactions for MAST3 Gene

SuperPathways for MAST3 Gene

No Data Available

SIGNOR curated interactions for MAST3 Gene

Activates:
Other effect:

Gene Ontology (GO) - Biological Process for MAST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007010 cytoskeleton organization IBA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with MAST3: view

No data available for Pathways by source for MAST3 Gene

Drugs & Compounds for MAST3 Gene

(2) Drugs for MAST3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for MAST3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MAST3: view

Transcripts for MAST3 Gene

Unigene Clusters for MAST3 Gene

Microtubule associated serine/threonine kinase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAST3 Gene

No ASD Table

Relevant External Links for MAST3 Gene

GeneLoc Exon Structure for
MAST3
ECgene alternative splicing isoforms for
MAST3

Expression for MAST3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAST3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAST3 Gene

This gene is overexpressed in Whole Blood (x6.4) and Brain - Cortex (x4.9).

Protein differential expression in normal tissues from HIPED for MAST3 Gene

This gene is overexpressed in Saliva (25.1), Blymphocyte (12.9), and Peripheral blood mononuclear cells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAST3 Gene



Protein tissue co-expression partners for MAST3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAST3 Gene:

MAST3

SOURCE GeneReport for Unigene cluster for MAST3 Gene:

Hs.466184

Evidence on tissue expression from TISSUES for MAST3 Gene

  • Nervous system(4.5)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with MAST3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAST3 Gene

Orthologs for MAST3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAST3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAST3 34 35
  • 97.35 (n)
dog
(Canis familiaris)
Mammalia MAST3 34 35
  • 88.26 (n)
cow
(Bos Taurus)
Mammalia MAST3 34 35
  • 86.64 (n)
rat
(Rattus norvegicus)
Mammalia Mast3 34
  • 82.42 (n)
mouse
(Mus musculus)
Mammalia Mast3 34 16 35
  • 82.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAST3 35
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 68 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves MAST3 34 35
  • 75.18 (n)
lizard
(Anolis carolinensis)
Reptilia MAST3 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mast3 34
  • 69 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100535762 34
  • 66.48 (n)
BX004890.2 35
  • 61 (a)
OneToMany
MAST3 (1 of 2) 35
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6498 35
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea kin-4 35
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN82 35
  • 26 (a)
ManyToMany
FPK1 35
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToMany
Species where no ortholog for MAST3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAST3 Gene

ENSEMBL:
Gene Tree for MAST3 (if available)
TreeFam:
Gene Tree for MAST3 (if available)

Paralogs for MAST3 Gene

Paralogs for MAST3 Gene

(18) SIMAP similar genes for MAST3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MAST3: view

Variants for MAST3 Gene

Sequence variations from dbSNP and Humsavar for MAST3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000005947 -- 18,145,477(+) TGGGC(A/G)TGTTA intron-variant
rs1000093999 -- 18,096,425(+) TGCAG(C/T)GGCTA intron-variant, upstream-variant-2KB
rs1000108044 -- 18,097,237(+) CAGCG(A/G)CGCTA intron-variant, upstream-variant-2KB
rs1000191428 -- 18,122,404(+) GGTCA(A/G)TGTGT intron-variant
rs1000204935 -- 18,120,325(+) AGCCC(A/C)TATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAST3 Gene

Variant ID Type Subtype PubMed ID
esv2658066 CNV deletion 23128226
esv2718285 CNV deletion 23290073
esv3556132 CNV deletion 23714750
nsv1130730 CNV deletion 24896259
nsv1138675 CNV deletion 24896259
nsv1151018 CNV deletion 26484159
nsv1160591 CNV deletion 26073780
nsv1160592 CNV deletion 26073780
nsv2429 CNV deletion 18451855
nsv470130 CNV loss 18288195
nsv833773 CNV loss 17160897
nsv833774 CNV loss 17160897
nsv833775 CNV loss 17160897
nsv952420 CNV deletion 24416366

Variation tolerance for MAST3 Gene

Residual Variation Intolerance Score: 4.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.65; 65.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAST3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAST3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAST3 Gene

Disorders for MAST3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAST3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
inflammatory bowel disease 6
  • ibd6
- elite association - COSMIC cancer census association via MalaCards
Search MAST3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAST3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAST3
genes like me logo Genes that share disorders with MAST3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAST3 Gene

Publications for MAST3 Gene

  1. Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. (PMID: 15951562) Valiente M. … Pulido R. (J. Biol. Chem. 2005) 3 4 64
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4 64
  4. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3 64
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3 64

Products for MAST3 Gene

Sources for MAST3 Gene

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