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MAST2 Gene

protein-coding   GIFtS: 59
GCID: GC01P046252

Microtubule Associated Serine/Threonine Kinase 2

  Search for MAST2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Microtubule Associated Serine/Threonine Kinase 21 2     MTSSK2
MAST2052 3 5     Microtubule Associated Testis Specific Serine/Threonine Protein Kinase2
EC 2.7.11.13 8     Microtubule-Associated Serine/Threonine-Protein Kinase 22
KIAA08073 5     EC 2.7.118

External Ids:    HGNC: 190351   Entrez Gene: 231392   Ensembl: ENSG000000860157   OMIM: 6122575   UniProtKB: Q6P0Q83   
ORGUL members:         

Export aliases for MAST2 gene to outside databases

Previous GC identifers: GC01P045639 GC01P045981 GC01P046041 GC01P044384


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MAST2 Gene:
MAST2 (microtubule associated serine/threonine kinase 2) is a protein-coding gene. GO annotations related to this gene include microtubule binding and protein serine/threonine kinase activity. An important paralog of this gene is MAST3.

UniProtKB/Swiss-Prot: MAST2_HUMAN, Q6P0Q8
Function: Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins.
Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a
multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in
macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By
similarity)

Gene Wiki entry for MAST2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAST2 gene promoter:
         AP-2rep   USF1   Bach2   NRSF form 1   HSF1 (long)   NRSF form 2   HSF2   FOXJ2 (long isoform)   HSF1short   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAST2 promoter sequence
   Search Chromatin IP Primers for MAST2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAST2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34.1

MAST2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAST2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P046252:  view genomic region     (about GC identifiers)

Start:
46,252,659 bp from pter      End:
46,501,796 bp from pter
Size:
249,138 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MAST2_HUMAN, Q6P0Q8 (See protein sequence)
Recommended Name: Microtubule-associated serine/threonine-protein kinase 2  
Size: 1798 amino acids; 196436 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with CDHR2
Sequence caution: Sequence=AAH15816.2; Type=Erroneous initiation; Sequence=AAH15816.2; Type=Frameshift;
Positions=1114, 1387; Sequence=BAB40778.1; Type=Frameshift; Positions=1688; Sequence=CAH73245.1; Type=Erroneous
gene model prediction; Sequence=CAI16563.1; Type=Erroneous gene model prediction; Sequence=CAI21706.1;
Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for MAST2:
2KQF (3D)        2KYL (3D)    
Secondary accessions: O94899 Q5VT07 Q5VT08 Q7LGC4 Q8NDG1 Q96B94 Q9BYE8
Alternative splicing: 2 isoforms:  Q6P0Q8-1   Q6P0Q8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAST2: NX_Q6P0Q8

Explore proteomics data for MAST2 at MOPED

Post-translational modifications: 

  • Phosphorylated and ubiquitinated. N-terminal ubiquitination leads to degradation of MAST2 by proteasome-mediated
    proteolysis. N-terminal phosphorylation appears to be a prerequisite for ubiquitination (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAST2 (Q6P0Q8) (see all 36)
     RPRSRSL  KLTDFGL  LSFIHHQ  RSLSPGR 


    See MAST2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055927.2  
    ENSEMBL proteins: 
     ENSP00000354671   ENSP00000361078   ENSP00000361079  

    MAST2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for MAST2
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    Novus Biologicals MAST2 Proteins
    Novus Biologicals MAST2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAST2

     
    Search eBioscience for Proteins for MAST2 

    MAST2 Antibody Products:

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    Abcam antibodies for MAST2
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    LSBio Antibodies in human, mouse, rat for MAST2

    MAST2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAST2
    Cloud-Clone Corp. CLIAs for MAST2
    Search eBioscience for ELISAs for MAST2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Microtubule associated serine/threonine kinase 2
    MAST family
    Other AGC kinases

    Selected InterPro protein domains (see all 9):
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR015022 MA_Ser/Thr_Kinase_dom
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q6P0Q8

    ProtoNet protein and cluster: Q6P0Q8

    2 Blocks protein domains:
    IPB000961 Protein kinase C-terminal domain
    IPB001478 PDZ/DHR/GLGF domain


    UniProtKB/Swiss-Prot: MAST2_HUMAN, Q6P0Q8
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with MAST2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAST2_HUMAN, Q6P0Q8
    Function: Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins.
    Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a
    multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in
    macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By
    similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding ISS--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI12117771
         
    Find genes that share ontologies with MAST2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MAST2:
     Decreased substrate adherent c  Increased G2M DNA content 

         1 MGI phenotypic allele for Mast2 (no phenotypes)

    Find genes that share phenotypes with MAST2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAST2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAST2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAST2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAST2

    miRNA
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    miRTarBase miRNAs that target MAST2:
    hsa-mir-18a-3p (MIRT040977)

    Block miRNA regulation of human, mouse, rat MAST2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAST2 (see all 9):
    hsa-miR-301b hsa-miR-301a hsa-miR-3666 hsa-miR-454 hsa-miR-4295 hsa-miR-466 hsa-miR-130a hsa-miR-3941
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MAST2

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    GenScript: all cDNA clones in your preferred vector: MAST2 (NM_015112)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAST2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAST2
    Addgene plasmids for MAST2 

    Cell Line
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAST2_HUMAN, Q6P0Q8: Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side
    (Potential). Note=Recruited to the sub-membranous area on interaction with CDHR2
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol3
    nucleus2
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IEA--
    GO:0015630microtubule cytoskeleton IEA--

    Find genes that share ontologies with MAST2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAST2
    Interactions:

        GeneGlobe Interaction Network for MAST2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAST2 (Q6P0Q81, 2, 3 ENSP000003546714) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A3P487641, 2, 3, ENSP000002649384EBI-493777,EBI-7816923 MINT-1892413 MINT-1892385 I2D: score=2 STRING: ENSP00000264938
    CDHR2Q9BYE91, 3, ENSP000002619444EBI-493777,EBI-493793 I2D: score=2 STRING: ENSP00000261944
    SMN1Q166372, 3MINT-8271267 I2D: score=2 
    SMN2Q166372, 3MINT-8271267 I2D: score=2 
    SH3GL2Q999622, 3MINT-8270528 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ISS--
    GO:0045075regulation of interleukin-12 biosynthetic process ISS--
    GO:0048515spermatid differentiation ISS--

    Find genes that share ontologies with MAST2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAST2

    3 HMDB Compounds for MAST2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAST2 gene: 
    NM_015112.2  

    Unigene Cluster for MAST2:

    Microtubule associated serine/threonine kinase 2
    Hs.319481  [show with all ESTs]
    Unigene Representative Sequence: NM_015112
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470809 ENST00000361297(uc001coy.1 uc001cpa.3 uc001cov.3 uc001cow.3)
    ENST00000372008(uc009vya.3 uc001coz.1) ENST00000482881 ENST00000488619
    ENST00000467367 ENST00000498668 ENST00000477968 ENST00000492813 ENST00000372009

    miRNA
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    Block miRNA regulation of human, mouse, rat MAST2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAST2 (see all 9):
    hsa-miR-301b hsa-miR-301a hsa-miR-3666 hsa-miR-454 hsa-miR-4295 hsa-miR-466 hsa-miR-130a hsa-miR-3941
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector: MAST2 (NM_015112)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAST2
    Addgene plasmids for MAST2 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAST2
      QuantiTect SYBR Green Assays in human, mouse, rat MAST2
      QuantiFast Probe-based Assays in human, mouse, rat MAST2

    Additional mRNA sequence: 

    AB018350.2 AB047005.1 AK027123.1 AK055291.1 AK096519.1 AK309510.1 AL137594.1 AL833919.1 
    BC006166.1 BC015816.2 BC065499.1 

    12 DOTS entries:

    DT.314520  DT.100780290  DT.92043189  DT.91741129  DT.91708985  DT.40202305  DT.408119  DT.92013364 
    DT.95244976  DT.91811124  DT.95355684  DT.97818154 

    Selected AceView cDNA sequences (see all 213):

    CN480167 BC065499 F26720 BC015816 BM715505 AK027123 BU175336 BM673970 
    AK096519 BQ070626 AB018350 AL137594 BQ050660 BQ719207 AA884014 BQ677278 
    BC006166 BM713140 BM471504 BE394196 CA488352 BI771067 AW576573 BQ016827 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAST2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^
    SP1:                                      -     -     -                                         -                       -                       -               
    SP2:                                                                                            -                       -                       -               
    SP3:                                      -                                                                                                                     
    SP4:                                                  -                                                                                                         
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
    SP1:                                      -         
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for MAST2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAST2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGAGGCTGC
    MAST2 Expression
    About this image

    MAST2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAST2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.319481

    UniProtKB/Swiss-Prot: MAST2_HUMAN, Q6P0Q8
    Tissue specificity: Abundant in the testis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAST2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAST2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mast21 , 5 microtubule associated serine/threonine kinase 21, 5 86.09(n)1
    88.16(a)1
      4 (53.10 cM)5
    177761  NM_001042743.21  NP_001036208.11 
     1163067625 
    chicken
    (Gallus gallus)
    Aves MAST21 microtubule associated serine/threonine kinase 2 73.66(n)
    82.24(a)
      424606  XM_004936758.1  XP_004936815.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAST26
    microtubule associated serine/threonine kinase 2
    81(a)
    1 ↔ 1
    4(111167444-111372399)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mast21 microtubule associated serine/threonine kinase 2 71.39(n)
    81.4(a)
      779595  NM_001128649.1  NP_001122121.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mast21 microtubule associated serine/threonine kinase 2 71.35(n)
    79.25(a)
      100001267  XM_001341269.5  XP_001341305.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG64986
    --
    33(a)
    1 → many
    3L(15559113-15569413)
    worm
    (Caenorhabditis elegans)
    Secernentea kin-46
    Protein KIN-4, isoform g
    32(a)
    1 → many
    IV(11425742-11447065) WBGene00002192
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIN826
    FPK16
    Putative serine/threonine protein kinase implicate...
    Ser/Thr protein kinase that regulates the putative...
    27(a)
    25(a)
    many ↔ many
    many ↔ many
    III(274404-276566) YCR091W
    XIV(708523-711204) YNR047W


    ENSEMBL Gene Tree for MAST2 (if available)
    TreeFam Gene Tree for MAST2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAST2 gene
    MAST32  MAST12  MAST42  
    Selected SIMAP similar genes for MAST2 using alignment to 4 protein entries:     MAST2_HUMAN (see all proteins) (see all similar genes):
    DKFZp434N0810    MAST3    MAST4    MAST1    RPS6KA3    PRKACB
    KIN27    RPS6KA2    ARHGAP23    PRKACA    STK38L    PRKACG
    RPS6KB2    CDC42BPB    STK38    DKFZp564L2416    PDPK2    PRKCH

    Find genes that share paralogs with MAST2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAST2 (see all 4532)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0407724
    An ovarian mucinous carcinoma sample4--see VAR_0407722 K E mis40--------
    VAR_0407744
    A breast mucinous carcinoma sample4--see VAR_0407742 G A mis40--------
    rs1887381761,2
    --46267512(+) TGAGAC/TGGAGT 1 -- us2k10--------
    rs1923051321,2
    --46267531(+) GTCACC/TCAGGC 1 -- us2k10--------
    rs1847475441,2
    --46267778(+) GCACCC/TGGTCC 1 -- us2k10--------
    rs1894923191,2
    --46267883(+) GAACCC/TGTTGA 1 -- us2k10--------
    rs75252811,2
    C,F,H--46267923(+) GATGAG/AACTTG 1 -- us2k122Minor allele frequency- A:0.12NS EA NA WA CSA 2011
    rs1808354971,2
    --46268533(+) AGAGGA/GAGGCC 1 -- us2k10--------
    rs1509177661,2
    --46268535(+) AGGGAG/TGCCAG 1 -- us2k10--------
    rs1389893411,2
    --46268612(+) GCCACA/GGCAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAST2 (46252659 - 46501796 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAST2 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv5205CNV Deletion18987735
    esv2663245CNV Deletion23128226
    esv1000231CNV Deletion20482838
    esv2747885CNV Deletion23290073
    esv1778390CNV Deletion17803354
    esv2583928CNV Deletion19546169
    esv2662133CNV Deletion23128226
    esv271472CNV Insertion20981092
    nsv522438CNV Loss19592680
    nsv437479CNV Loss16327808

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAST2
    DNA2.0 Custom Variant and Variant Library Synthesis for MAST2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612257    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for MAST2:
    Mastitis

    Find genes that share disorders with MAST2           About GenesLikeMe

    Genetic Association Database (GAD): MAST2

    Export disorders for MAST2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAST2 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with MAST2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation. (PubMed id 12117771)1, 2 Okazaki N.... Koga H. (Carcinogenesis 2002)
    5. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    6. Increased activity associated with the MAST205 protein kinase complex during mammalian spermiogenesis. (PubMed id 8902215)1, 2 Walden P.D. and Millette C.F. (Biol. Reprod. 1996)
    7. Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability. (PubMed id 15308666)1, 9 Xiong H....Unkeless J.C. (J. Biol. Chem. 2004)
    8. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. MAST205 competes with cystic fibrosis transmembrane conductance regulator (CFTR)-associated ligand for binding to CFTR to regulate CFTR-mediated fluid transport. (PubMed id 23504457)1 Ren A....Naren A.P. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23139 HGNC: 19035 AceView: MAST2 Ensembl:ENSG00000086015 euGenes: HUgn23139
    ECgene: MAST2 H-InvDB: MAST2

    (According to HUGE)
    About This Section

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    HUGE: KIAA0807

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAST2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAST2 gene:
    Search GeneIP for patents involving MAST2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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