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MAST1 Gene(Protein Coding)

Microtubule Associated Serine/Threonine Kinase 1

GCID:
GC19P012834
GIFtS:
53
Genes Participants
UDN Logo

Aliases for MAST1 Gene

Aliases for MAST1 Gene

  • Microtubule Associated Serine/Threonine Kinase 1 2 3 5
  • Syntrophin-Associated Serine/Threonine-Protein Kinase 3 4
  • EC 2.7.11.1 4 63
  • SAST 3 4
  • Syntrophin Associated Serine/Threonine Kinase 3
  • EC 2.7.11 63
  • KIAA0973 4
  • SAST170 3

External Ids for MAST1 Gene

Previous GeneCards Identifiers for MAST1 Gene

  • GC19U900423
  • GC19P012811
  • GC19P012949
  • GC19P012520

Summaries for MAST1 Gene

GeneCards Summary for MAST1 Gene

MAST1 (Microtubule Associated Serine/Threonine Kinase 1) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAST4.

UniProtKB/Swiss-Prot for MAST1 Gene

  • Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity).

Gene Wiki entry for MAST1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAST1 Gene

Genomics for MAST1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for MAST1 Gene

Enhancers for MAST1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAST1 on UCSC Golden Path with GeneCards custom track

Promoters for MAST1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAST1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MAST1 gene promoter:

Genomic Location for MAST1 Gene

Chromosome:
19
Start:
12,833,934 bp from pter
End:
12,874,953 bp from pter
Size:
41,020 bases
Orientation:
Plus strand

Genomic View for MAST1 Gene

Genes around MAST1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAST1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAST1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAST1 Gene

Proteins for MAST1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MAST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2H9-MAST1_HUMAN
    Recommended name:
    Microtubule-associated serine/threonine-protein kinase 1
    Protein Accession:
    Q9Y2H9
    Secondary Accessions:
    • O00114
    • Q8N6X0

    Protein attributes for MAST1 Gene

    Size:
    1570 amino acids
    Molecular mass:
    170677 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Part of a low affinity complex that associates with, but is distinct from, the postsynaptic density. Interacts with SNTB2 (By similarity).
    SequenceCaution:
    • Sequence=AAB51171.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH27985.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA76817.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAST1 Gene

neXtProt entry for MAST1 Gene

Proteomics data for MAST1 Gene at MOPED

Protein Expression for MAST1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MAST1 Gene

Q9Y2H9:

Post-translational modifications for MAST1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAST1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MAST1 Gene

Gene Families for MAST1 Gene

HGNC:
IUPHAR :

Protein Domains for MAST1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAST1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2H9

UniProtKB/Swiss-Prot:

MAST1_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MAST1: view

Function for MAST1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for MAST1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity).

Enzyme Numbers (IUBMB) for MAST1 Gene

Gene Ontology (GO) - Molecular Function for MAST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
genes like me logo Genes that share ontologies with MAST1: view

Phenotypes for MAST1 Gene

GenomeRNAi human phenotypes for MAST1:
genes like me logo Genes that share phenotypes with MAST1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MAST1

miRNA for MAST1 Gene

miRTarBase miRNAs that target MAST1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAST1 Gene

Localization for MAST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAST1 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Colocalizes with syntrophins at the cell membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAST1 Gene COMPARTMENTS Subcellular localization image for MAST1 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 3
cytosol 3
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for MAST1 Gene

Pathways & Interactions for MAST1 Gene

SuperPathways for MAST1 Gene

PathCards logoMore details on SuperPathways for MAST1
No Data Available

SIGNOR curated interactions for MAST1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for MAST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,ISS --
genes like me logo Genes that share ontologies with MAST1: view

No data available for Pathways by source for MAST1 Gene

Drugs & Compounds for MAST1 Gene

Products:

  1. Drug

(2) Drugs for MAST1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for MAST1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MAST1: view

Transcripts for MAST1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for MAST1 Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(89) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAST1 Gene

Microtubule associated serine/threonine kinase 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAST1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - -
SP2:
SP3:
SP4: -
SP5: -
SP6: -
SP7:
SP8:

ExUns: 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for MAST1 Gene

GeneLoc Exon Structure for
MAST1
ECgene alternative splicing isoforms for
MAST1

Expression for MAST1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for MAST1 Gene

mRNA expression in normal human tissues for MAST1 Gene
mRNA expression by BioGPS for MAST1 GenemRNA expression by GTEx for MAST1 Gene

mRNA differential expression in normal tissues according to GTEx for MAST1 Gene

This gene is overexpressed in Brain - Cerebellum (x9.6), Brain - Cerebellar Hemisphere (x9.0), Brain - Cortex (x6.4), and Brain - Frontal Cortex (BA9) (x4.5).

Protein differential expression in normal tissues from HIPED for MAST1 Gene

This gene is overexpressed in Serum (47.6), Fetal Brain (11.1), and Frontal cortex (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAST1 Gene



SOURCE GeneReport for Unigene cluster for MAST1 Gene Hs.227489

genes like me logo Genes that share expression patterns with MAST1: view

Protein tissue co-expression partners for MAST1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MAST1 Gene

Orthologs for MAST1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAST1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia MAST1 35
  • 89.32 (n)
  • 95.21 (a)
MAST1 36
  • 94 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia MAST1 35
  • 88.81 (n)
  • 95.42 (a)
-- 36
  • 95 (a)
 OneToMany
-- 36
  • 94 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Mast1 35
  • 85.99 (n)
  • 94.52 (a)
Mast1 16
Mast1 36
  • 94 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia MAST1 35
  • 98.68 (n)
  • 98.88 (a)
MAST1 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia MAST1 35
  • 85.57 (n)
  • 94.13 (a)
oppossum
(Monodelphis domestica)
 Mammalia MAST1 36
  • 88 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia MAST1 36
  • 88 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia MAST1 36
  • 77 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia mast1 35
  • 67.75 (n)
  • 74.17 (a)
zebrafish
(Danio rerio)
 Actinopterygii mast1a 35
  • 71 (n)
  • 79.84 (a)
mast1a 36
  • 64 (a)
 OneToMany
mast1b 36
  • 65 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta CG6498 36
  • 30 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea kin-4 36
  • 30 (a)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes FPK1 36
  • 24 (a)
 ManyToMany
KIN82 36
  • 27 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 43 (a)
 OneToMany
Species with no ortholog for MAST1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAST1 Gene

ENSEMBL:
Gene Tree for MAST1 (if available)
TreeFam:
Gene Tree for MAST1 (if available)

Paralogs for MAST1 Gene

Paralogs for MAST1 Gene

(27) SIMAP similar genes for MAST1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MAST1: view

Variants for MAST1 Gene

Sequence variations from dbSNP and Humsavar for MAST1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_040768 A metastatic melanoma sample
VAR_040769 An ovarian serous carcinoma sample
rs35071862 - 12,874,031(+) GCCAC(C/T)CGGAT reference, missense
rs35052801 - 12,871,051(+) AGGTA(G/T)CAGTG reference, missense
rs7256794 -- 12,864,794(+) GCCCA(C/T)TTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAST1 Gene

Variant ID Type Subtype PubMed ID
dgv3733n71 CNV Loss 21882294
nsv911082 CNV Loss 21882294
nsv2420 CNV Insertion 18451855
nsv911083 CNV Loss 21882294
nsv911084 CNV Loss 21882294
esv2663622 CNV Deletion 23128226

Variation tolerance for MAST1 Gene

Residual Variation Intolerance Score: 1.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAST1 Gene

Human Gene Mutation Database (HGMD)
MAST1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAST1 Gene

Disorders for MAST1 Gene

Relevant External Links for MAST1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAST1

No disorders were found for MAST1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAST1 Gene

Publications for MAST1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Sast124, a novel splice variant of syntrophin-associated serine/threonine kinase (SAST), is specifically localized in the restricted brain regions. (PMID: 12614677) Yano R. … Hashikawa T. (Neuroscience 2003) 3 23
  3. Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases. (PMID: 10404183) Lumeng C. … Chamberlain J.S. (Nat. Neurosci. 1999) 3 23
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  5. Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. (PMID: 21163940) Soler-LA^pez M. … Aloy P. (Genome Res. 2011) 3

Products for MAST1 Gene

  • Addgene plasmids for MAST1

Sources for MAST1 Gene

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