MAST1 Gene

Aliases
for MAST1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC19U900423 GC19P012811 GC19P012520

Summaries
for MAST1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for MAST1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000019.9  NT_011295.12  NC_018930.2  

SwitchGear Promoter luciferase reporter plasmid: MAST1 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAST1

MAST1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P012949:  view genomic region     (about GC identifiers)

Proteins
for MAST1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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2 PDB 3D structures from and Proteopedia for MAST1:

2M9X (3D)        3PS4 (3D)    

Explore the universe of human proteins at neXtProt for MAST1: NX_Q9Y2H9

Explore proteomics data for MAST1 at MOPED

Post-translational modifications: 

MAST1 Human Recombinant Protein Products:

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	Cloud-Clone Corp. Proteins for MAST1
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	Search GeneTex for Proteins for MAST1
	antibodies-online proteins for MAST1 (2 products)
	antibodies-online peptides for MAST1

MAST1 Antibody Products:

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	antibodies-online antibodies for MAST1 (11 products)

MAST1 Assay Products:

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	Cloud-Clone Corp. ELISAs for MAST1 Cloud-Clone Corp. CLIAs for MAST1
	Search eBioscience for ELISAs for MAST1
	antibodies-online kits for MAST1 (6 products)

Domains /
Families
for MAST1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9Y2H9

Find genes that share domains with MAST1           About GenesLikeMe

Function
for MAST1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Enzyme Numbers (IUBMB): EC 2.7.11.1^{1 2} EC 2.7.11²

     Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

genOway: Develop your customized and physiologically relevant rodent model for MAST1

miRNA Products:		miRTarBase miRNAs that target MAST1: hsa-mir-148b-3p (MIRT019332), hsa-mir-335-5p (MIRT017887)
		Block miRNA regulation of human, mouse, rat MAST1 using miScript Target Protectors
		4 qRT-PCR Assays for microRNAs that regulate MAST1:
		hsa-miR-493* hsa-let-7g* hsa-let-7a-2* hsa-miR-3924
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MAST1
		Predesigned siRNA for gene silencing in human, mouse, rat MAST1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for MAST1

Clone Products:		OriGene clones in human, mouse for MAST1 (see all 6) OriGene ORF clones in mouse, rat for MAST1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MAST1 (NM_014975)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAST1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAST1
		Addgene plasmids for MAST1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MAST1
		Browse ESI BIO Cell Lines and PureStem Progenitors for MAST1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAST1

Localization
for MAST1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	5
cytosol	3
cytoskeleton	2
nucleus	2
endoplasmic reticulum	1
mitochondrion	1
peroxisome	1

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Gene Ontology (GO): 4 cellular component terms:    About this table

Pathways & Interactions
for MAST1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 3 biological process terms:    About this table

Drugs & Compounds
for MAST1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for MAST1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for MAST1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MAST1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for MAST1
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAST1
		QuantiTect SYBR Green Assays in human, mouse, rat MAST1
		QuantiFast Probe-based Assays in human, mouse, rat MAST1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAST1

Orthologs
for MAST1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for MAST1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for MAST1 gene

MAST2²  MAST3²  MAST4²  

Selected SIMAP similar genes for MAST1 using alignment to 4 protein entries:     MAST1_HUMAN (see all proteins) (see all similar genes):

MAST4    MAST3    STK38L    RPS6KA2    RPS6KA3    MAST2

PRKACA    SGK3    KIN27    PRKACB    PRKACG    PRKY

PRKX    STK38    AKT1    AKT2    CIT    AKT3

Find genes that share paralogs with MAST1           About GenesLikeMe

Genomic Variants
for MAST1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MAST1 (see all 780)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
VAR_0407694		An ovarian serous carcinoma sample4	--	see VAR_040769	2	H Y	mis4		0	--	--	--	--
VAR_0407684		A metastatic melanoma sample4	--	see VAR_040768	2	A T	mis4		0	--	--	--	--
rs104240011,2	C,F,H	--	12948462(+)	tgtttG/Aattta	1	--	us2k1		24		NS EA NA WA CSA	2351
rs358586681,2	C	--	12948572(+)	GAAAC-/TTTTTT	1	--	us2k1		1		CSA	2
rs2007096951,2	C	--	12948572(+)	GAAACC/TTTTTT	1	--	us2k1		0	--	--	--	--
rs1476819301,2		--	12948661(+)	CAACCC/TCCCAA	1	--	us2k1		0	--	--	--	--
rs1820610321,2		--	12948815(+)	ACACAC/TGCTGA	1	--	us2k1		0	--	--	--	--
rs118832031,2	H	--	12948820(+)	CGCTGA/GTATGC	1	--	us2k1		0	--	--	--	--
rs1407208791,2		--	12948825(+)	ATATGC/TCAACT	1	--	us2k1		0	--	--	--	--
rs773073031,2	C	--	12948837(+)	ACTTGA/CCTTTA	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for MAST1 (12944765 - 12985766 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for MAST1:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2663622	CNV	Deletion	23128226
nsv2420	CNV	Insertion	18451855
nsv911082	CNV	Loss	21882294
nsv911084	CNV	Loss	21882294
nsv911083	CNV	Loss	21882294
dgv3733n71	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MAST1

DNA2.0 Custom Variant and Variant Library Synthesis for MAST1

Disorders / Diseases
for MAST1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for MAST1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (Nature 2004)
3. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)^{1, 2} Nagase T.... Ohara O. (DNA Res. 1999)
4. Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases. (PubMed id 10404183)^{1, 9} Lumeng C....Chamberlain J.S. (Nat. Neurosci. 1999)
5. Sast124, a novel splice variant of syntrophin-associated serine/threonine kinase (SAST), is specifically localized in the restricted brain regions. (PubMed id 12614677)^{1, 9} Yano R....Hashikawa T. (Neuroscience 2003)
6. Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. (PubMed id 21163940)¹ Soler-LA^pez M....Aloy P. (Genome Res. 2011)
7. Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer. (PubMed id 22101766)¹ Robinson D.R....Chinnaiyan A.M. (Nat. Med. 2011)
8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (amp 2011)
9. Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. (PubMed id 20029029)¹ Deribe Y.L....Dikic I. (Sci Signal 2009)
10. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)² Greenman C.... Stratton M.R. (Nature 2007)

External Searches for MAST1 gene

Genome Databases showing MAST1 gene

Other Databases showing MAST1 gene

Specialized Databases showing MAST1 gene

Products
for MAST1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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