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Aliases for MAST1 Gene

Aliases for MAST1 Gene

  • Microtubule Associated Serine/Threonine Kinase 1 2 3
  • SAST 3 4 6
  • Syntrophin-Associated Serine/Threonine-Protein Kinase 3 4
  • EC 4 63
  • KIAA0973 4 6
  • Microtubule-Associated Serine/Threonine-Protein Kinase 1 3
  • Syntrophin Associated Serine/Threonine Kinase 3
  • EC 2.7.11 63
  • SAST170 3

External Ids for MAST1 Gene

Previous GeneCards Identifiers for MAST1 Gene

  • GC19U900423
  • GC19P012811
  • GC19P012949
  • GC19P012520

Summaries for MAST1 Gene

GeneCards Summary for MAST1 Gene

MAST1 (Microtubule Associated Serine/Threonine Kinase 1) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is MAST4.

UniProtKB/Swiss-Prot for MAST1 Gene

  • Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity).

Gene Wiki entry for MAST1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAST1 Gene

Genomics for MAST1 Gene

Regulatory Elements for MAST1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAST1 Gene

12,833,951 bp from pter
12,874,952 bp from pter
41,002 bases
Plus strand

Genomic View for MAST1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAST1 Gene

Proteins for MAST1 Gene

  • Protein details for MAST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Microtubule-associated serine/threonine-protein kinase 1
    Protein Accession:
    Secondary Accessions:
    • O00114
    • Q8N6X0

    Protein attributes for MAST1 Gene

    1570 amino acids
    Molecular mass:
    170677 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Part of a low affinity complex that associates with, but is distinct from, the postsynaptic density. Interacts with SNTB2 (By similarity).
    • Sequence=AAB51171.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH27985.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA76817.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAST1 Gene

neXtProt entry for MAST1 Gene

Proteomics data for MAST1 Gene at MOPED

Post-translational modifications for MAST1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAST1 Gene

Domains for MAST1 Gene

Suggested Antigen Peptide Sequences for MAST1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9Y2H9
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MAST1: view

Function for MAST1 Gene

Molecular function for MAST1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function: Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity).

Enzyme Numbers (IUBMB) for MAST1 Gene

Gene Ontology (GO) - Molecular Function for MAST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity ISS --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 20029029
genes like me logo Genes that share ontologies with MAST1: view

Phenotypes for MAST1 Gene

GenomeRNAi human phenotypes for MAST1:
genes like me logo Genes that share phenotypes with MAST1: view

Animal Model Products

CRISPR Products

miRNA for MAST1 Gene

miRTarBase miRNAs that target MAST1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAST1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MAST1 Gene

Localization for MAST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAST1 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Colocalizes with syntrophins at the cell membrane. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for MAST1 Gene COMPARTMENTS Subcellular localization image for MAST1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MAST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with MAST1: view

Pathways for MAST1 Gene

SuperPathways for MAST1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation ISS --
GO:0007010 cytoskeleton organization ISS --
GO:0035556 intracellular signal transduction ISS --
genes like me logo Genes that share ontologies with MAST1: view

No data available for Pathways by source for MAST1 Gene

Compounds for MAST1 Gene

(3) HMDB Compounds for MAST1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • Magnesium
genes like me logo Genes that share compounds with MAST1: view

Transcripts for MAST1 Gene

Unigene Clusters for MAST1 Gene

Microtubule associated serine/threonine kinase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAST1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MAST1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAST1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - -
SP4: -
SP5: -
SP6: -

ExUns: 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b
SP1: - -

Relevant External Links for MAST1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAST1 Gene

mRNA expression in normal human tissues for MAST1 Gene

mRNA differential expression in normal tissues according to GTEx for MAST1 Gene

This gene is overexpressed in Brain - Cerebellum (9.6), Brain - Cerebellar Hemisphere (9.0), Brain - Cortex (6.4), and Brain - Frontal Cortex (BA9) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAST1 Gene

SOURCE GeneReport for Unigene cluster for MAST1 Gene Hs.227489

genes like me logo Genes that share expressions with MAST1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MAST1 Gene

Orthologs for MAST1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAST1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAST1 35
  • 98.68 (n)
  • 98.88 (a)
MAST1 36
  • 100 (a)
(Bos Taurus)
Mammalia MAST1 35
  • 89.32 (n)
  • 95.21 (a)
MAST1 36
  • 94 (a)
(Canis familiaris)
Mammalia -- 36
  • 95 (a)
-- 36
  • 94 (a)
MAST1 35
  • 88.81 (n)
  • 95.42 (a)
(Mus musculus)
Mammalia Mast1 35
  • 85.99 (n)
  • 94.52 (a)
Mast1 16
Mast1 36
  • 94 (a)
(Monodelphis domestica)
Mammalia MAST1 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia MAST1 36
  • 88 (a)
(Rattus norvegicus)
Mammalia MAST1 35
  • 85.57 (n)
  • 94.13 (a)
(Anolis carolinensis)
Reptilia MAST1 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mast1 35
  • 67.75 (n)
  • 74.17 (a)
(Danio rerio)
Actinopterygii mast1a 35
  • 71 (n)
  • 79.84 (a)
mast1a 36
  • 64 (a)
mast1b 36
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6498 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea kin-4 36
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPK1 36
  • 24 (a)
KIN82 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for MAST1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAST1 Gene

Gene Tree for MAST1 (if available)
Gene Tree for MAST1 (if available)

Paralogs for MAST1 Gene

Paralogs for MAST1 Gene

genes like me logo Genes that share paralogs with MAST1: view

Variants for MAST1 Gene

Sequence variations from dbSNP and Humsavar for MAST1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1065199 -- 12,874,564(+) CTTTC(C/T)GTGCC reference, synonymous-codon
rs1124820 -- 12,846,300(-) gaagg(C/T)gggag intron-variant
rs1210385 -- 12,863,080(-) ctcac(C/T)gcccc intron-variant
rs1468045 -- 12,865,528(+) ACGGA(A/G)AGATG intron-variant
rs1468046 -- 12,865,639(+) tccag(C/T)tgggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAST1 Gene

Variant ID Type Subtype PubMed ID
dgv3733n71 CNV Loss 21882294
nsv911082 CNV Loss 21882294
nsv2420 CNV Insertion 18451855
nsv911083 CNV Loss 21882294
nsv911084 CNV Loss 21882294
esv2663622 CNV Deletion 23128226

Relevant External Links for MAST1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAST1 Gene

Disorders for MAST1 Gene

No disorders were found for MAST1 Gene.

No data available for UniProtKB/Swiss-Prot for MAST1 Gene

Publications for MAST1 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases. (PMID: 10404183) Lumeng C. … Chamberlain J.S. (Nat. Neurosci. 1999) 3 23
  4. Sast124, a novel splice variant of syntrophin-associated serine/threonine kinase (SAST), is specifically localized in the restricted brain regions. (PMID: 12614677) Yano R. … Hashikawa T. (Neuroscience 2003) 3 23
  5. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4

Products for MAST1 Gene

Sources for MAST1 Gene

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