MASP2 Gene
protein-coding GIFtS: 66
GCID: GC01M011086
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|
mannan-binding lectin serine peptidase 2(Previous names: mannan-binding lectin serine protease 2, mannan-binding...)
(Previous symbol: MASP1P1)
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Aliases
for MASP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mannan-Binding Lectin Serine Peptidase 21 2 | | MBL-Associated Serine Protease 22 3 | | MASP1P11 2 | | MAP192 | | Mannan-Binding Lectin Serine Peptidase 1 Pseudogene 11 2 | | MBL-Associated Plasma Protein Of 19 KD2 | | Mannan-Binding Lectin Serine Protease 1 Pseudogene 11 2 | | SMAP1 | | Mannan-Binding Lectin Serine Protease 21 2 | | Small MBL-Associated Protein2 | | Mannose-Binding Protein-Associated Serine Protease 22 3 | | EC 3.4.21.1043 | | MASP-22 3 | | EC 3.4.218 |
Export aliases for MASP2 gene to outside databasesPrevious GC identifers: GC01M011047 GC01M010930 GC01M010695 GC01M010796 GC01M011020 GC01M011009 GC01M010238 |
Summaries
for MASP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MASP2:
The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharidesexpressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding twoRARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform iscleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of thetrypsin family of peptidases. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MASP2_HUMAN, O00187Function: Serum protease that plays an important role in the activation of the complement system via mannose-bindinglectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to theformation of C3 convertase
Gene Wiki entry for MASP2
|
Genomic Views
for MASP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MASP2 gene promoter:
Max1 Max NRSF form 1 NRSF form 2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for MASP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MASP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.3-p36.2 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36.3-p36.2MASP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M011086: view genomic region
(about GC identifiers)
Start:
|
11,086,580 bp from pter |
End:
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11,107,290 bp from pter |
Size:
|
20,711 bases |
Orientation:
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minus strand |
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Proteins
for MASP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MASP2_HUMAN, O00187 (See
protein sequence)Recommended Name: Mannan-binding lectin serine protease 2 precursor Size: 686 amino acids; 75702 Da
Subunit: Homodimer; disulfide-linked. Binds MBL2. Isoform 2 binds to MASP1. Binds SERPING1. Dimerization and MBL2binding requires calcium ions
Subcellular location: Secreted
5 PDB 3D structures from  and Proteopedia  for MASP2:1Q3X (3D)
1SZB (3D)
1ZJK (3D)
3TVJ (3D)
4FXG (3D)
Secondary accessions: A8K458 A8MWJ2 O75754 Q5TEQ5 Q5TER0 Q96QG4 Q9BZH0 Q9H498 Q9H499 Q9UBP3 Q9UC48Q9ULC7 Q9UMV3 Q9Y270Alternative splicing: 2 isoforms: O00187-1 O00187-2 Explore the universe of human proteins at neXtProt for MASP2: NX_O00187
Post-translational modifications:
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGFdomains (By similarity)1
Activated by cleavage after Arg-444. The uncleaved zymogen is inactive towards synthetic substrates, but has sufficientactivity to effect autocatalytic cleavage1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00187
3 DME Specific Peptides for MASP2 (O00187)
MASP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_006601.2 NP_631947.1
ENSEMBL proteins: ENSP00000383690 ENSP00000383691 Reactome Protein details: O00187
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- |
MASP2 for ontologies About GeneDecksing
MASP2 Antibody Products:
Assay Products for MASP2: |
Protein
Domains /
Families
for MASP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MASP2 for domains About GeneDecksing
5/11 InterPro domains/families (see all 11):Graphical View of Domain Structure for InterPro Entry O00187ProtoNet protein and cluster: O00187 5 Blocks protein families: IPB000436 Sushi domain/SCR domain/CCP module IPB000859 CUB domain IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature IPB001881 EGF-like calcium-binding
UniProtKB/Swiss-Prot: MASP2_HUMAN, O00187Similarity: Belongs to the peptidase S1 familySimilarity: Contains 2 CUB domainsSimilarity: Contains 1 EGF-like domainSimilarity: Contains 1 peptidase S1 domainSimilarity: Contains 2 Sushi (CCP/SCR) domains |
Function
for MASP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MASP2_HUMAN, O00187Function: Serum protease that plays an important role in the activation of the complement system via mannose-bindinglectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to theformation of C3 convertaseCatalytic activity: Selective cleavage after Arg-223 in complement component C2 (-Ser-Leu-Gly-Arg- -Lys-Ile-Gln-Ile)and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg- -Ala-Leu-Glu-Ile) Genatlas biochemistry entry for MASP2:mannan-binding lectin serine protease 2,including an alternatively spliced (truncated) isoform of 19kDa (Map19),alsoincluded in the complex formed with MBL2 and MASP1 to form the antibody independent activator of the classical pathwayof complement
Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.1041
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MASP2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MASP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MASP2 (NM_139208) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MASP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MASP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MASP2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
MASP2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for MASP2:
Animal Models:
Mouse knock-out Masp2tm1Wjsc for MASP2
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Masp2):
MASP2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MASP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cleavage of Alpha-1-Microglobulin | | | 2 | Immune System | | | 3 | Complement and coagulation cascades | | | 4 | Classical Complement Pathway | | | 5 | Immune response_Alternative complement pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for MASP2
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MASP2
1  GeneGo (Thomson Reuters) Pathway for MASP2
1  BioSystems Pathway for MASP2
5/6 
Reactome Pathways for MASP2 (see all 6)
2 
Kegg Pathways (Kegg details for MASP2):
MASP2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MASP2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/13 Interacting proteins for MASP2 (O001872, 3 ENSP000003836904) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001867 | complement activation, lectin pathway |
TAS | -- | | GO:0006508 | proteolysis |
IEA | -- | | GO:0006956 | complement activation |
TAS | -- | | GO:0006958 | complement activation, classical pathway |
IEA | -- | | GO:0045087 | innate immune response |
TAS | -- |
MASP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for MASP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MASP2 for compounds About GeneDecksing
 Browse Tocris compounds for MASP2
1 HMDB Compound for MASP2 About this table
1 DrugBank Compound for MASP2 About this table
6 Novoseek chemical compound relationships for MASP2 gene About this table
Search CenterWatch for drugs/clinical trials and news about MASP2
|
Transcripts
for MASP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MASP2 gene (2 alternative transcripts): NM_006610.3 NM_139208.2 Unigene Cluster for MASP2: Mannan-binding lectin serine peptidase 2 Hs.655645 [show with all ESTs]Unigene Representative Sequence: NM_0066104 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000400897(uc001aru.3) ENST00000478645 ENST00000480221(uc001arw.3 uc001arx.2)
ENST00000400898(uc001arv.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MASP2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MASP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MASP2 (NM_139208) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MASP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MASP2 |
Additional cDNA sequence: AB008047.1 AK290823.1 BC052299.1 BC067359.1 BC080556.1 X98400.1 Y09926.1 Y18281.1 Y18282.1 Y18283.1 Y18284.1 4 DOTS entries: DT.75143502 DT.100019857 DT.101122 DT.100729932 24/38 AceView cDNA sequences (see all 38): BC067359 BQ648719 AB008047 BQ646367 NM_139208 BE673751 BQ644570 BC052299 BC080556 NM_006610 AI288745 X98400 AA033700 AW137730 BQ654231 BQ653181 AI914242 Y18281 BV184156 AW827159 BQ648641 Y09926 Y18283 BQ650766
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MASP2 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
|---|
|
| SP1: | | | | | | | - | | | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MASP2
|
Expression
for MASP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MASP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACCCAATAA
About this image
See MASP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MASP2
SOURCE GeneReport for Unigene cluster: Hs.655645
UniProtKB/Swiss-Prot: MASP2_HUMAN, O00187Tissue specificity: Plasma
SABiosciences Custom PCR Arrays for MASP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MASP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MASP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MASP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MASP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MASP2 |
Orthologs
for MASP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MASP2 gene from 3/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MASP21 |
mannan-binding lectin serine peptidase 2 |
64.01(n)
56.19(a) |
|
407089 NM_213587.1 NP_998752.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
AB009072.12 |
-- |
74.56(n) |
|
AB009072.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.173912 |
Danio rerio, Similar to MASP-2 protein, clone IMAGE56 more |
77.04(n) |
|
BC046065.1 |
ENSEMBL Gene Tree for MASP2 (if available)
TreeFam Gene Tree for MASP2 (if available) |
Paralogs
for MASP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MASP2 gene
- PROZ2 PAMR12 C1S2 C1R2 C1RL2 F92 MASP12 F102
- F22 HPR2 HP2 PROC2 F72
15 SIMAP similar genes for MASP2 using alignment to 1 protein entry: MASP2_HUMAN:MASP1 DKFZp686O1553 C1R C1S KLK9 PRSS2
TRY8 CELA2A CTRB1 PRSS27 TRY6 CTRB2
CTRL KLK12 KLK8
MASP2 for paralogs About GeneDecksing
|
Genomic Variants
for MASP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MASP2 (11086580 - 11107290 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MASP2
2 CNVs: 67054 67053
Human Gene Mutation Database (HGMD): MASP2
Locus Specific Mutation Databases (LSDB): MASP2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MASP2 |
|
Disorders
/ Diseases
for MASP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MASP2 for disorders About GeneDecksing
OMIM gene information: 605102
OMIM disorders: --
UniProtKB/Swiss-Prot: MASP2_HUMAN, O00187
Defects in MASP2 are the cause of MASP2 deficiency (MASPD) [MIM:613791]. MASPD is a disorder that results inautoimmune manifestations, recurrent severe infections, and chronic inflammatory disease
20/36  diseases for MASP2 (see all 36): About MalaCardsage related macular degeneration pemphigus foliaceus non-hodgkin lymphoma macular degeneration
hereditary angioedema frontotemporal dementia chronic fatigue syndrome angioedema
esophageal squamous cell carcinoma cystic fibrosis squamous cell carcinoma hodgkin's lymphoma
rheumatic fever pemphigus chagas disease hepatitis c
dementia neutropenia fibrosis genetic disease
10 Novoseek disease relationships for MASP2 gene About this table
Genetic Association Database (GAD): MASP2
Human Genome Epidemiology (HuGE) Navigator: MASP2 (31 documents)
Export disorders for MASP2 gene to outside databases
|
Publications
for MASP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MASP2 gene, integrated from 9 sources (see all 164):
(articles sorted by number of sources associating them with MASP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Novel MASP2 variants detected among North African and Sub-Saharan individuals. (PubMed id 16029433)1, 2, 4, 9 Lozano F....Horcajada J.P. (2005)
- A second serine protease associated with mannan-binding lectin that activates complement. (PubMed id 9087411)1, 2, 3, 9 Thiel S.... Jensenius J.C. (1997)
- Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms. (PubMed id 17252003)1, 2, 9 Thiel S....Jensenius J.C. (2007)
- The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3. (PubMed id 11426320)1, 2, 9 Stover C.... Schwaeble W. (2001)
- Proteolytic activities of two types of mannose-binding lectin- associated serine protease. (PubMed id 10946292)1, 2, 9 Matsushita M.... Fujita T. (2000)
- The X-ray structure of human mannan-binding lectin-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L- ficolin. (PubMed id 15117939)1, 2, 9 Gregory L.A.... Gaboriaud C. (2004)
- A truncated form of mannose-binding lectin-associated serine protease (MASP)-2 expressed by alternative polyadenylation is a component of the lectin complement pathway. (PubMed id 10330290)1, 2, 9 Takahashi M.... Matsushita M. (1999)
- The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions. (PubMed id 15364579)1, 2, 9 Harmat V.... Zavodszky P. (2004)
- MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway. (PubMed id 9777418)1, 3, 9 Vorup-Jensen T....Thiel S. (1998)
- A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations. (PubMed id 16040602)1, 2, 9 Gal P.... Zavodszky P. (2005)
|
External Searches for MASP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MASP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MASP2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MASP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MASP2 | Pharmacogenomics, SNPs, Pathways | | MASP2base | http://bioinf.uta.fi/MASP2base/ |
|
| | |
About This Section
| Patent Information for MASP2 gene:
Search GeneIP for patents involving MASP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MASP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MASP2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MASP2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MASP2 | | | OriGene Protein Over-expression Lysate for MASP2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MASP2 | | OriGene 3'-UTR Clone for MASP2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MASP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MASP2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MASP2 | | OriGene Custom Protein Services for MASP2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MASP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MASP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MASP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MASP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MASP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MASP2 |
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| | | | Search Tocris compounds for MASP2 |
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 | | | MASP2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MASP2 |
|  |  |  | | | | Search ThermoFisher Antibodies for MASP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MASP2 |
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