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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAS1L Gene

protein-coding   GIFtS: 52
GCID: GC06M029454

MAS1 Oncogene-Like

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MAS1 Oncogene-Like1 2     MAS-L2
MRG2 3 5     dJ994E9.22
MAS-R2 3     Mas-Related G Protein-Coupled MRG2
MAS1-like2 3     Mas-Related G-Protein Coupled Receptor MRG2

External Ids:    HGNC: 139611   Entrez Gene: 1165112   Ensembl: ENSG000002046877   OMIM: 6072355   UniProtKB: P354103   

Export aliases for MAS1L gene to outside databases

Previous GC identifers: GC06M029511 GC06M029225 GC06M029562 GC06M029261


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MAS1L Gene: 
MAS1L (MAS1 oncogene-like) is a protein-coding gene. Diseases associated with MAS1L include median rhomboid glossitis, and glossitis, and among its related super-pathways are Peptide GPCRs and Class A/1 (Rhodopsin-like receptors). GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX3.

Gene Wiki entry for MAS1L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  
NT_167248.1  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAS1L gene promoter:
         GATA-3   Tal-1   C/EBPalpha   Evi-1   GATA-1   E47   POU2F1   POU2F1a   c-Myb   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAS1L promoter sequence
   Search SABiosciences Chromatin IP Primers for MAS1L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAS1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21

MAS1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAS1L gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M029454:  view genomic region     (about GC identifiers)

Start:
29,454,474 bp from pter      End:
29,455,738 bp from pter
Size:
1,265 bases      Orientation:
minus strand

6/7 alternative locations (see all 7):
Chr6-,NT_167248 757,828-758,964      Chr6-,NT_113891.2 973,324-974,460      Chr6-,NT_167244 758,021-759,157     
Chr6-,NT_167249 795,075-796,211      Chr6-,NT_167245 757,874-759,010      Chr6-,NT_167247 757,725-758,861     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MAS1L_HUMAN, P35410 (See protein sequence)
Recommended Name: Mas-related G-protein coupled receptor MRG  
Size: 378 amino acids; 42411 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q5SUN5

Explore the universe of human proteins at neXtProt for MAS1L: NX_P35410

Explore proteomics data for MAS1L at MOPED 

MAS1L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

MAS1L Protein Expression

REFSEQ proteins: NP_443199.1  
ENSEMBL proteins: 
 ENSP00000366331  

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Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA--
GO:0005730NOT nucleolus IDA--
GO:0005737cytoplasm IDA--
GO:0005886plasma membrane IDA--
GO:0016021integral to membrane NAS1723144

MAS1L for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
GPCRAO: GPCR / Class A : Orphans

IUPHAR Guide to PHARMACOLOGY protein family classification: MAS1L 
Class A Orphans

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR026234 MRGPCRFAMILY
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P35410

ProtoNet protein and cluster: P35410

UniProtKB/Swiss-Prot: MAS1L_HUMAN, P35410
Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily


MAS1L for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity NAS1723144
     
MAS1L for ontologies           About GeneDecksing


Phenotypes:
     4 GenomeRNAi human phenotypes for MAS1L:
 Decreased Salmonella enterica   Decreased cilium length after   Decreased nuclei size in G2M  Increased gamma-H2AX phosphory 

Animal Models:
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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAS1L 

miRNA
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Gene Editing
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAS1L


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for MAS1L About                                                                                                See pathways by source

SuperPathContained pathways About
1Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46
2Class A/1 (Rhodopsin-like receptors)
GPCRs, Class A Rhodopsin-like0.41

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for MAS1L
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


1 BioSystems Pathway for MAS1L
    GPCRs, Class A Rhodopsin-like



MAS1L for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAS1L

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway NAS1723144

MAS1L for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MAS1L

Search CenterWatch for drugs/clinical trials and news about MAS1L

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MAS1L gene: 
NM_052967.1  

Unigene Cluster for MAS1L:

MAS1 oncogene-like
Hs.533297  [show with all ESTs]
Unigene Representative Sequence: BC095511
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000377127(uc011dlq.2)
miRNA
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Inhib. RNA
Products:
     
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GenScript: all cDNA clones in your preferred vector: MAS1L (NM_052967)
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Sirion Biotech Customized lentivirus for stable overexpression of MAS1L 
                     Customized lentivirus expression plasmids for stable overexpression of MAS1L 
Primer
Products:
    
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAS1L
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAS1L

Additional mRNA sequence: 

BC069127.1 BC069345.1 BC095511.1 BC101176.2 BC101177.1 

1 DOTS entry:

DT.99949745 

4 AceView cDNA sequences:

BC069127 BC069345 NM_052967 CN842138 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MAS1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGGAGAACCT
MAS1L Expression
About this image


See MAS1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAS1L

SOURCE GeneReport for Unigene cluster: Hs.533297
    SABiosciences Custom PCR Arrays for MAS1L
Primer
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SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MAS1L
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAS1L
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAS1L

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MAS1L gene from 3/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia MAS1L6
MAS1 oncogene-like
28(a)
1 ↔ 1
18(47211313-47213754)
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
19(a)
1 → many
JH376180.1(56001-57008)
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 19)
--
31(a)
29(a)
(see all 19)
many ↔ many
many ↔ many
(see all 19)
4(16488532-16489341)
4(16394563-16395360)


ENSEMBL Gene Tree for MAS1L (if available)
TreeFam Gene Tree for MAS1L (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MAS1L gene
MRGPRX32  MRGPRD2  MRGPRG2  MAS12  MRGPRF2  MRGPRX42  MRGPRX12  MRGPRE2  
MRGPRX22  
7 SIMAP similar genes for MAS1L using alignment to 2 protein entries:     MAS1L_HUMAN (see all proteins):
MRGPRX4    MRGPRX1    MRGPRX3    MRGPRX2    MRGPRD    MAS1
MRGPRE

MAS1L for paralogs           About GeneDecksing


5/9 Pseudogenes.org Pseudogenes for MAS1L (see all 9)
PGOHUM00000243120 PGOHUM00000243122 PGOHUM00000235889 PGOHUM00000245329 PGOHUM00000236811


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/131 SNPs in MAS1L are shown (see all 131)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1493623561,2
C--29454062(+) TGCCCA/GCAATA 1 -- ds50010--------
rs119657331,2
C,F,H--29454150(+) TGATGC/TCTCTT 1 -- ds50017Minor allele frequency- T:0.11NS WA 1182
rs1160176331,2
C,F--29454161(+) GGTAAT/CTCCGA 1 -- ds50011Minor allele frequency- C:0.05WA 118
rs1830736401,2
--29454230(+) TTTGGA/TGGATG 1 -- ds50010--------
rs94685361,2
C,F,H--29454365(+) ACTGGG/ACTTAC 1 -- ds50015Minor allele frequency- A:0.01NS EA WA 538
rs1456666081,2
--29454369(+) GGCTTA/TCTGCC 1 -- ds50010--------
rs1383291871,2
--29454371(+) CTTACA/TGCCTA 1 -- ds50010--------
rs1429200801,2
C--29454453(+) TGATTA/TGAATA 1 -- ds50010--------
rs20669511,2
C,F,A,H--29454489(-) TCTGCA/CTCATA 1 -- ds500129Minor allele frequency- C:0.16EA NS MN NA WA CSA EU 5391
rs1461292091,2
C--29454515(+) ATGTGC/TACAAT 1 -- ds50010--------

HapMap Linkage Disequilibrium report for MAS1L (29454474 - 29455738 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for MAS1L:    About this table     
Variant IDTypeSubtypePubMed ID
nsv883528CNV Loss21882294

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 607235    OMIM disorders: --

5 diseases for MAS1L:    About MalaCards
median rhomboid glossitis    glossitis    systemic lupus erythematosus    lupus erythematosus
neuronitis


MAS1L for disorders           About GeneDecksing

Genetic Association Database (GAD): MAS1L
Human Genome Epidemiology (HuGE) Navigator: MAS1L (1 document)

Export disorders for MAS1L gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MAS1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with MAS1L)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and functional characterization of a novel mas-related gene, modulating intracellular angiotensin II actions. (PubMed id 1723144)1, 2, 9 Monnot C....Clauser E. (1991)
  2. High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (2009)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
  5. Angiotensin metabolites can stimulate receptors of the Mas-related genes family. (PubMed id 18636314)1, 9 Gembardt F....Walther T. (2008)
  6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  8. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PubMed id 11551509)1 Dong X.... Anderson D.J. (2001)
  9. Identification of small molecule antagonists of the human mas-related gene-X1 receptor. (PubMed id 16510108)9 Kunapuli P....Strulovici B. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 116511 HGNC: 13961 AceView: MAS1L Ensembl:ENSG00000204687 euGenes: HUgn116511
ECgene: MAS1L H-InvDB: MAS1L

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MAS1L Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MAS1L Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MAS1L gene:
Search GeneIP for patents involving MAS1L

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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