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Aliases for MAS1L Gene

Aliases for MAS1L Gene

  • MAS1 Proto-Oncogene Like, G Protein-Coupled Receptor 2 3
  • MRG 3 4 6
  • MAS1 Oncogene-Like 2 3
  • MAS1-Like 3 4
  • MAS-R 3 4
  • Mas-Related G-Protein Coupled Receptor MRG 3
  • Mas-Related G Protein-Coupled MRG 3
  • DJ994E9.2 3
  • MAS-L 3

External Ids for MAS1L Gene

Summaries for MAS1L Gene

GeneCards Summary for MAS1L Gene

MAS1L (MAS1 Proto-Oncogene Like, G Protein-Coupled Receptor) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX4.

Gene Wiki entry for MAS1L Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAS1L Gene

Genomics for MAS1L Gene

Genomic Location for MAS1L Gene

29,486,697 bp from pter
29,487,956 bp from pter
1,260 bases
Minus strand

Genomic View for MAS1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAS1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for MAS1L Gene

Proteins for MAS1L Gene

  • Protein details for MAS1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mas-related G-protein coupled receptor MRG
    Protein Accession:
    Secondary Accessions:
    • Q5SUN5

    Protein attributes for MAS1L Gene

    378 amino acids
    Molecular mass:
    42411 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAS1L Gene

Proteomics data for MAS1L Gene at MOPED

Post-translational modifications for MAS1L Gene

Other Protein References for MAS1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAS1L Gene

Domains for MAS1L Gene

Gene Families for MAS1L Gene

  • GPCRAO :GPCR / Class A : Orphans

Protein Domains for MAS1L Gene


  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.:
    • P35410
genes like me logo Genes that share domains with MAS1L: view

Function for MAS1L Gene

Gene Ontology (GO) - Molecular Function for MAS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity NAS 1723144
genes like me logo Genes that share ontologies with MAS1L: view
genes like me logo Genes that share phenotypes with MAS1L: view

miRNA for MAS1L Gene

miRTarBase miRNAs that target MAS1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAS1L Gene

Localization for MAS1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAS1L Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MAS1L Gene COMPARTMENTS Subcellular localization image for MAS1L gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for MAS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0016021 integral component of membrane NAS 1723144
genes like me logo Genes that share ontologies with MAS1L: view

Pathways for MAS1L Gene

SuperPathways for MAS1L Gene

genes like me logo Genes that share pathways with MAS1L: view

Pathways by source for MAS1L Gene

1 BioSystems pathway for MAS1L Gene

Interacting Proteins for MAS1L Gene

Gene Ontology (GO) - Biological Process for MAS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway NAS 1723144
genes like me logo Genes that share ontologies with MAS1L: view

Transcripts for MAS1L Gene

mRNA/cDNA for MAS1L Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAS1L Gene

MAS1 oncogene-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAS1L Gene

No ASD Table

Relevant External Links for MAS1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAS1L Gene

mRNA expression in normal human tissues for MAS1L Gene

mRNA differential expression in normal tissues according to GTEx for MAS1L Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (6.3) and Esophagus - Muscularis (5.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MAS1L Gene

SOURCE GeneReport for Unigene cluster for MAS1L Gene Hs.533297

genes like me logo Genes that share expressions with MAS1L: view

Orthologs for MAS1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAS1L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAS1L 36
  • 98.67 (n)
  • 97.6 (a)
(Mus musculus)
Mammalia Mrgpra9 37
  • 31 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 30 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 26 (a)
-- 37
  • 28 (a)
-- 37
  • 27 (a)
(Gallus gallus)
Aves -- 37
  • 20 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 27 (a)
-- 37
  • 28 (a)
-- 37
  • 29 (a)
-- 37
  • 28 (a)
-- 37
  • 25 (a)
-- 37
  • 28 (a)
-- 37
  • 29 (a)
-- 37
  • 26 (a)
-- 37
  • 32 (a)
-- 37
  • 19 (a)
-- 37
  • 26 (a)
-- 37
  • 24 (a)
-- 37
  • 24 (a)
-- 37
  • 24 (a)
-- 37
  • 27 (a)
-- 37
  • 29 (a)
Species with no ortholog for MAS1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAS1L Gene

Gene Tree for MAS1L (if available)
Gene Tree for MAS1L (if available)

Paralogs for MAS1L Gene

Paralogs for MAS1L Gene

Selected SIMAP similar genes for MAS1L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MAS1L: view

Variants for MAS1L Gene

Sequence variations from dbSNP and Humsavar for MAS1L Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2066951 -- 29,486,712(-) TCTGC(A/C)TCATA downstream-variant-500B
rs9257869 -- 29,488,395(+) CTCCT(G/T)CCTCG upstream-variant-2KB
rs9348832 -- 29,488,244(+) TGTCT(A/G)GTCCA upstream-variant-2KB
rs9468536 -- 29,486,588(+) ACTGG(A/G)CTTAC downstream-variant-500B
rs11752280 -- 29,488,878(+) TGAAC(A/T)GACTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAS1L Gene

Variant ID Type Subtype PubMed ID
nsv883528 CNV Loss 21882294

Relevant External Links for MAS1L Gene

HapMap Linkage Disequilibrium report

Disorders for MAS1L Gene

Relevant External Links for MAS1L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MAS1L: view

No data available for UniProtKB/Swiss-Prot for MAS1L Gene

Publications for MAS1L Gene

  1. Cloning and functional characterization of a novel mas-related gene, modulating intracellular angiotensin II actions. (PMID: 1723144) Monnot C. … Clauser E. (Mol. Endocrinol. 1991) 3 4 23
  2. Angiotensin metabolites can stimulate receptors of the Mas-related genes family. (PMID: 18636314) Gembardt F. … Walther T. (Mol. Cell. Biochem. 2008) 3 23
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 49

Products for MAS1L Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MAS1L
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MAS1L
    • Block miRNA regulation of MAS1L using miScript Target Protectors

    Sources for MAS1L Gene

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