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Aliases for MAS1L Gene

Aliases for MAS1L Gene

  • MAS1 Proto-Oncogene Like, G Protein-Coupled Receptor 2 3 5
  • MAS1 Oncogene-Like 2 3
  • MAS1-Like 3 4
  • MAS-R 3 4
  • MRG 3 4
  • Mas-Related G-Protein Coupled Receptor MRG 3
  • Mas-Related G Protein-Coupled MRG 3
  • DJ994E9.2 3
  • MAS-L 3

External Ids for MAS1L Gene

Previous GeneCards Identifiers for MAS1L Gene

  • GC06M029511
  • GC06M029225
  • GC06M029562
  • GC06M029454
  • GC06M029261

Summaries for MAS1L Gene

GeneCards Summary for MAS1L Gene

MAS1L (MAS1 Proto-Oncogene Like, G Protein-Coupled Receptor) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX3.

Gene Wiki entry for MAS1L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAS1L Gene

Genomics for MAS1L Gene

Regulatory Elements for MAS1L Gene

Enhancers for MAS1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G029477 0.6 FANTOM5 17.1 +9.9 9859 0.6 GATA2 E2F5 USF2 FOXJ2 MAS1L OR12D3 OR5V1 UBD LINC01015 OR2H2 OR14J1 MAS1LP1
GH06G029467 0.3 FANTOM5 12.1 +20.3 20257 0.3 OR10C1 ZFP57 MAS1L OR11A1 OR14J1 OR2W1 OR2J3 OR2B3 OR12D2 OR5V1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAS1L on UCSC Golden Path with GeneCards custom track

Genomic Location for MAS1L Gene

Chromosome:
6
Start:
29,486,697 bp from pter
End:
29,487,956 bp from pter
Size:
1,260 bases
Orientation:
Minus strand

Genomic View for MAS1L Gene

Genes around MAS1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAS1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAS1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MAS1L Gene

  • Protein details for MAS1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35410-MAS1L_HUMAN
    Recommended name:
    Mas-related G-protein coupled receptor MRG
    Protein Accession:
    P35410
    Secondary Accessions:
    • Q5SUN5

    Protein attributes for MAS1L Gene

    Size:
    378 amino acids
    Molecular mass:
    42411 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAS1L Gene

Post-translational modifications for MAS1L Gene

Other Protein References for MAS1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAS1L Gene

Domains & Families for MAS1L Gene

Gene Families for MAS1L Gene

Protein Domains for MAS1L Gene

Suggested Antigen Peptide Sequences for MAS1L Gene

Graphical View of Domain Structure for InterPro Entry

P35410

UniProtKB/Swiss-Prot:

MAS1L_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MAS1L: view

Function for MAS1L Gene

Gene Ontology (GO) - Molecular Function for MAS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity NAS 1723144
genes like me logo Genes that share ontologies with MAS1L: view
genes like me logo Genes that share phenotypes with MAS1L: view

Animal Model Products

miRNA for MAS1L Gene

miRTarBase miRNAs that target MAS1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAS1L Gene

Localization for MAS1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAS1L Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAS1L gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 4

Gene Ontology (GO) - Cellular Components for MAS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 1723144
genes like me logo Genes that share ontologies with MAS1L: view

Pathways & Interactions for MAS1L Gene

genes like me logo Genes that share pathways with MAS1L: view

Pathways by source for MAS1L Gene

1 BioSystems pathway for MAS1L Gene

Interacting Proteins for MAS1L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366331%0d%0a9606.ENSP00000362249%0d%0a
Selected Interacting proteins: ENSP00000366331 for MAS1L Gene via STRING

Symbol External ID(s) Details
AK1

Gene Ontology (GO) - Biological Process for MAS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway NAS 1723144
genes like me logo Genes that share ontologies with MAS1L: view

No data available for SIGNOR curated interactions for MAS1L Gene

Transcripts for MAS1L Gene

mRNA/cDNA for MAS1L Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAS1L Gene

MAS1 oncogene-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAS1L Gene

No ASD Table

Relevant External Links for MAS1L Gene

GeneLoc Exon Structure for
MAS1L
ECgene alternative splicing isoforms for
MAS1L

Expression for MAS1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAS1L Gene

mRNA differential expression in normal tissues according to GTEx for MAS1L Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x6.3) and Esophagus - Muscularis (x5.5).

Protein differential expression in normal tissues from HIPED for MAS1L Gene

This gene is overexpressed in NK cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAS1L Gene



Protein tissue co-expression partners for MAS1L Gene

NURSA nuclear receptor signaling pathways regulating expression of MAS1L Gene:

MAS1L

SOURCE GeneReport for Unigene cluster for MAS1L Gene:

Hs.533297
genes like me logo Genes that share expression patterns with MAS1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAS1L Gene

Orthologs for MAS1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAS1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAS1L 34
  • 98.67 (n)
mouse
(Mus musculus)
Mammalia Mrgpra9 35
  • 31 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 30 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 28 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 20 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 32 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 19 (a)
ManyToMany
Species where no ortholog for MAS1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAS1L Gene

ENSEMBL:
Gene Tree for MAS1L (if available)
TreeFam:
Gene Tree for MAS1L (if available)

Paralogs for MAS1L Gene

Variants for MAS1L Gene

Sequence variations from dbSNP and Humsavar for MAS1L Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000009425 -- 29,488,356(+) CAGCT(-/CACTG)GAACC intron-variant, upstream-variant-2KB
rs1001537013 -- 29,489,527(+) AGCCT(A/G)CTCTC nc-transcript-variant, upstream-variant-2KB
rs1001651577 -- 29,489,379(+) GTGTC(A/G)GGATC intron-variant, upstream-variant-2KB
rs1002408193 -- 29,486,623(+) CTTCC(A/C)ACCAC intron-variant, downstream-variant-500B
rs1004890390 -- 29,489,047(+) GCTAT(A/G)TTAAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAS1L Gene

Variant ID Type Subtype PubMed ID
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259

Variation tolerance for MAS1L Gene

Residual Variation Intolerance Score: 75.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAS1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAS1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAS1L Gene

Disorders for MAS1L Gene

Relevant External Links for MAS1L

Genetic Association Database (GAD)
MAS1L
Human Genome Epidemiology (HuGE) Navigator
MAS1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAS1L

No disorders were found for MAS1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAS1L Gene

Publications for MAS1L Gene

  1. Cloning and functional characterization of a novel mas-related gene, modulating intracellular angiotensin II actions. (PMID: 1723144) Monnot C. … Clauser E. (Mol. Endocrinol. 1991) 3 4 22 64
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  3. Angiotensin metabolites can stimulate receptors of the Mas-related genes family. (PMID: 18636314) Gembardt F. … Walther T. (Mol. Cell. Biochem. 2008) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64

Products for MAS1L Gene

Sources for MAS1L Gene

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