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Aliases for MAS1L Gene

Aliases for MAS1L Gene

  • MAS1 Proto-Oncogene Like, G Protein-Coupled Receptor 2 3 5
  • MAS1 Oncogene-Like 2 3
  • MAS1-Like 3 4
  • MAS-R 3 4
  • MRG 3 4
  • Mas-Related G Protein-Coupled MRG 3
  • DJ994E9.2 3
  • MAS-L 3

External Ids for MAS1L Gene

Previous GeneCards Identifiers for MAS1L Gene

  • GC06M029511
  • GC06M029225
  • GC06M029562
  • GC06M029454
  • GC06M029261

Summaries for MAS1L Gene

GeneCards Summary for MAS1L Gene

MAS1L (MAS1 Proto-Oncogene Like, G Protein-Coupled Receptor) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX4.

Gene Wiki entry for MAS1L Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAS1L Gene

Genomics for MAS1L Gene

Regulatory Elements for MAS1L Gene

Enhancers for MAS1L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAS1L on UCSC Golden Path with GeneCards custom track

Genomic Location for MAS1L Gene

Chromosome:
6
Start:
29,486,697 bp from pter
End:
29,487,956 bp from pter
Size:
1,260 bases
Orientation:
Minus strand

Genomic View for MAS1L Gene

Genes around MAS1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAS1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAS1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MAS1L Gene

  • Protein details for MAS1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35410-MAS1L_HUMAN
    Recommended name:
    Mas-related G-protein coupled receptor MRG
    Protein Accession:
    P35410
    Secondary Accessions:
    • Q5SUN5

    Protein attributes for MAS1L Gene

    Size:
    378 amino acids
    Molecular mass:
    42411 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAS1L Gene

Proteomics data for MAS1L Gene at MOPED

Post-translational modifications for MAS1L Gene

  • Glycosylation at Asn 54 and Asn 57

Other Protein References for MAS1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAS1L Gene

Domains & Families for MAS1L Gene

Gene Families for MAS1L Gene

Protein Domains for MAS1L Gene

Suggested Antigen Peptide Sequences for MAS1L Gene

Graphical View of Domain Structure for InterPro Entry

P35410

UniProtKB/Swiss-Prot:

MAS1L_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MAS1L: view

Function for MAS1L Gene

genes like me logo Genes that share phenotypes with MAS1L: view

Animal Model Products

miRNA for MAS1L Gene

miRTarBase miRNAs that target MAS1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAS1L Gene

Localization for MAS1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAS1L Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAS1L Gene COMPARTMENTS Subcellular localization image for MAS1L gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MAS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with MAS1L: view

Pathways & Interactions for MAS1L Gene

SuperPathways for MAS1L Gene

genes like me logo Genes that share pathways with MAS1L: view

Pathways by source for MAS1L Gene

1 BioSystems pathway for MAS1L Gene

Interacting Proteins for MAS1L Gene

Gene Ontology (GO) - Biological Process for MAS1L Gene

None

No data available for SIGNOR curated interactions for MAS1L Gene

Drugs & Compounds for MAS1L Gene

No Compound Related Data Available

Transcripts for MAS1L Gene

mRNA/cDNA for MAS1L Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAS1L Gene

MAS1 oncogene-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAS1L Gene

No ASD Table

Relevant External Links for MAS1L Gene

GeneLoc Exon Structure for
MAS1L
ECgene alternative splicing isoforms for
MAS1L

Expression for MAS1L Gene

mRNA expression in normal human tissues for MAS1L Gene

mRNA differential expression in normal tissues according to GTEx for MAS1L Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x6.3) and Esophagus - Muscularis (x5.5).

Protein differential expression in normal tissues from HIPED for MAS1L Gene

This gene is overexpressed in NK cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MAS1L Gene



SOURCE GeneReport for Unigene cluster for MAS1L Gene Hs.533297

genes like me logo Genes that share expression patterns with MAS1L: view

Protein tissue co-expression partners for MAS1L Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MAS1L Gene

Orthologs for MAS1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAS1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAS1L 35
  • 98.67 (n)
  • 97.6 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 30 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mrgpra9 36
  • 31 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 26 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 20 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
Species with no ortholog for MAS1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAS1L Gene

ENSEMBL:
Gene Tree for MAS1L (if available)
TreeFam:
Gene Tree for MAS1L (if available)

Paralogs for MAS1L Gene

(7) SIMAP similar genes for MAS1L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MAS1L: view

Variants for MAS1L Gene

Sequence variations from dbSNP and Humsavar for MAS1L Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_049416 -

Structural Variations from Database of Genomic Variants (DGV) for MAS1L Gene

Variant ID Type Subtype PubMed ID
nsv883528 CNV Loss 21882294

Variation tolerance for MAS1L Gene

Residual Variation Intolerance Score: 75.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MAS1L Gene

Disorders for MAS1L Gene

Relevant External Links for MAS1L

Genetic Association Database (GAD)
MAS1L
Human Genome Epidemiology (HuGE) Navigator
MAS1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAS1L

No disorders were found for MAS1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAS1L Gene

Publications for MAS1L Gene

  1. Cloning and functional characterization of a novel mas-related gene, modulating intracellular angiotensin II actions. (PMID: 1723144) Monnot C. … Clauser E. (Mol. Endocrinol. 1991) 3 4 23 67
  2. Angiotensin metabolites can stimulate receptors of the Mas-related genes family. (PMID: 18636314) Gembardt F. … Walther T. (Mol. Cell. Biochem. 2008) 3 23
  3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Identification of small molecule antagonists of the human mas-related gene-X1 receptor. (PMID: 16510108) Kunapuli P. … Strulovici B. (Anal. Biochem. 2006) 23

Products for MAS1L Gene

Sources for MAS1L Gene

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