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MAS1 Gene

protein-coding   GIFtS: 58
GCID: GC06P160327

MAS1 Oncogene

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MAS1 Oncogene1 2
MAS2 3
MGRA2
Mas-Related G Protein-Coupled Receptor A2
Proto-Oncogene Mas2

External Ids:    HGNC: 68991   Entrez Gene: 41422   Ensembl: ENSG000001303687   OMIM: 1651805   UniProtKB: P042013   

Export aliases for MAS1 gene to outside databases

Previous GC identifers: GC06P159767 GC06P160201 GC06P160237 GC06P160298 GC06P157798


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAS1 Gene:
This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for
angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway.
The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and
cardioprotection by mediating the effects of angiotensin-(1-7). (provided by RefSeq, May 2012)

GeneCards Summary for MAS1 Gene:
MAS1 (MAS1 oncogene) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and peptide hormone binding. An important paralog of this gene is MRGPRX3.

UniProtKB/Swiss-Prot: MAS_HUMAN, P04201
Function: Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1
(angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1
levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C
signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by
MAS1

Gene Wiki entry for MAS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAS1 gene promoter:
         FAC1   POU2F1   p53   POU2F1a   Cart-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAS1 promoter sequence
   Search Chromatin IP Primers for MAS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3-q26   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q24-q27

MAS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAS1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P160327:  view genomic region     (about GC identifiers)

Start:
160,327,974 bp from pter      End:
160,329,108 bp from pter
Size:
1,135 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MAS_HUMAN, P04201 (See protein sequence)
Recommended Name: Proto-oncogene Mas  
Size: 325 amino acids; 37465 Da
Subunit: Interacts with AGTR1 (Probable)
Caution: Was originally (PubMed:3419518) thought to be a receptor for angiotensin II
Secondary accessions: E1P5B3 Q2TBC9 Q6FG47

Explore the universe of human proteins at neXtProt for MAS1: NX_P04201

Explore proteomics data for MAS1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5, Asn16, Asn22

  • See MAS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002368.1  
    ENSEMBL proteins: 
     ENSP00000252660  

    MAS1 Human Recombinant Protein Products:

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    antibodies-online peptides for MAS1

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    antibodies-online antibodies for MAS1 (40 products) 

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    antibodies-online kits for MAS1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: MAS1
    Class A Orphans

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000820 Proto-oncogene_Mas
     IPR026234 MRGPCRFAMILY
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P04201

    ProtoNet protein and cluster: P04201

    1 Blocks protein domain: IPB000820 Mas oncogene signature

    UniProtKB/Swiss-Prot: MAS_HUMAN, P04201
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with MAS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAS_HUMAN, P04201
    Function: Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1
    (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1
    levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C
    signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by
    MAS1

         Genatlas biochemistry entry for MAS1:
    MAS1 oncogene (angiotensin receptor), G protein coupled receptor superfamily,imprinted in breast tissue

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001595angiotensin receptor activity ISS--
    GO:0004930G-protein coupled receptor activity IDA16611642
    GO:0004945angiotensin type II receptor activity TAS3419518
    GO:0017046peptide hormone binding IEA--
    GO:0042277peptide binding ISS--
         
    Find genes that share ontologies with MAS1           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mas1):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  nervous system  renal/urinary system 

    Find genes that share phenotypes with MAS1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mas1tm1Bdr for MAS1

       genOway: Develop your customized and physiologically relevant rodent model for MAS1

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAS_HUMAN, P04201: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA16611642
    GO:0005887integral component of plasma membrane TAS3419518
    GO:0009986cell surface IEA--
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with MAS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAS1 About    
    See pathways by source

    SuperPathContained pathways About
    1Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics0.37
    ACE Inhibitor Pathway, Pharmacodynamics0.00
    Renin-angiotensin system0.37
    ACE Inhibitor Pathway0.00
    2Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43
    Neuroactive ligand-receptor interaction0.36
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46


    Find genes that share SuperPaths with MAS1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for MAS1
        ACE Inhibitor Pathway
    GPCRs, Class A Rhodopsin-like

    2 PharmGKB Pathways for MAS1
        ACE Inhibitor Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for MAS1):
        Neuroactive ligand-receptor interaction
    Renin-angiotensin system

        Pathway & Disease-focused RT2 Profiler PCR Array including MAS1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAS1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for MAS1 (P042013 ENSP000002526604) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGTP010193, ENSP000003556274I2D: score=1 STRING: ENSP00000355627
    SNTA1Q134243I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001933negative regulation of protein phosphorylation IEA--
    GO:0007186G-protein coupled receptor signaling pathway TAS3419518
    GO:0007250activation of NF-kappaB-inducing kinase activity IEA--
    GO:0007283spermatogenesis IEA--
    GO:0008283cell proliferation TAS3419518

    Find genes that share ontologies with MAS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAS1 (MAS)

    1 IUPHAR Ligand for MAS1 (MAS1)    About this table
    LigandTypeActionAffinityPubmed IDs
    angiotensin-(1-7)
    AgonistFull agonist12829792



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAS1 gene: 
    NM_002377.2  

    Unigene Cluster for MAS1:

    MAS1 oncogene
    Hs.99900  [show with all ESTs]
    Unigene Representative Sequence: M13150
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000252660(uc003qsz.3)
    miRNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAS1
      QuantiTect SYBR Green Assays in human, mouse, rat MAS1
      QuantiFast Probe-based Assays in human, mouse, rat MAS1

    Additional mRNA sequence: 

    BC069142.1 BC069581.1 BC110454.2 CR542261.1 M13150.1 

    1 DOTS entry:

    DT.40119864 

    5 AceView cDNA sequences:

    M13150 BC069142 NM_002377 BC069581 CR542261 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATACTAAT
    MAS1 Expression
    About this image

    MAS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.99900
        Pathway & Disease-focused RT2 Profiler PCR Array including MAS1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MAS1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mas11 , 5 MAS1 oncogene1, 5 85.39(n)1
    90.43(a)1
      17 (8.69 cM)5
    171711  NM_008552.41  NP_032578.21 
     128410795 
    chicken
    (Gallus gallus)
    Aves MAS11 MAS1 oncogene 65.43(n)
    59.26(a)
      428594  XM_426151.3  XP_426151.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    35(a)
    29(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    1(212063728-212064681)
    1(212068349-212069879)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004947611 proto-oncogene Mas-like 52.53(n)
    40.47(a)
      100494761  XM_002938871.1  XP_002938917.1 


    ENSEMBL Gene Tree for MAS1 (if available)
    TreeFam Gene Tree for MAS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAS1 gene
    MRGPRX32  MRGPRD2  MRGPRG2  MAS1L2  MRGPRF2  MRGPRX42  MRGPRX12  MRGPRE2  
    MRGPRX22  
    8 SIMAP similar genes for MAS1 using alignment to 1 protein entry:     MAS_HUMAN:
    MRGPRX2    MRGPRX1    MRGPRX3    MRGPRX4    MRGPRF    MRGPRD
    MAS1L    MRGPRE

    Find genes that share paralogs with MAS1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAS1 (see all 147)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2207251,2
    C,F,H--160325989(-) agacaC/Tgaagg 1 -- us2k114Minor allele frequency- T:0.01NA WA CSA EA 514
    rs93651121,2
    H--160326040(+) CACTAT/AGGACG 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs1895452141,2
    --160326068(+) CTGCCA/GCTCCT 1 -- us2k10--------
    rs1500137981,2
    --160326127(+) ACATCA/CGTTTG 1 -- us2k10--------
    rs1822381241,2
    --160326144(+) GTTGCA/TGTTAT 1 -- us2k10--------
    rs759395041,2
    C,F--160326147(+) GCTGTT/CATTGT 1 -- us2k11Minor allele frequency- C:0.03EA 120
    rs1443040671,2
    --160326255(+) CATGGG/TCTAAA 1 -- us2k10--------
    rs2207241,2
    C,F,A,H--160326268(-) CTCCCC/TCCACA 1 -- us2k1 trp318Minor allele frequency- T:0.37NS EA WA NA CSA 2338
    rs781949751,2
    C,F--160326289(+) ACATGG/TTGGTC 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs754338881,2
    F--160326296(+) GGTCTT/CACTTG 1 -- us2k12Minor allele frequency- C:0.03WA NA 238

    HapMap Linkage Disequilibrium report for MAS1 (160327974 - 160329108 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MAS1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAS1
    DNA2.0 Custom Variant and Variant Library Synthesis for MAS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 165180    OMIM disorders: --

    UniProtKB/Swiss-Prot: MAS_HUMAN, P04201
  • Note=The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells


  • Find genes that share disorders with MAS1           About GenesLikeMe

    Genetic Association Database (GAD): MAS1
    Human Genome Epidemiology (HuGE) Navigator: MAS1 (2 documents)
    Tumor Gene Database (TGDB): MAS1

    Export disorders for MAS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAS1 gene, integrated from 10 sources (see all 38) (see top 10):
    (articles sorted by number of sources associating them with MAS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Up-regulation of the angiotensin II type 1 receptor by the MAS proto- oncogene is due to constitutive activation of Gq/G11 by MAS. (PubMed id 16611642)1, 2, 9 Canals M.... Milligan G. (J. Biol. Chem. 2006)
    2. Interactions among related genes of renin-angiotensin system associated with type 2 diabetes. (PubMed id 20592051)1, 4 Yang J.K....Ma Y.H. (Diabetes Care 2010)
    3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. The mas oncogene encodes an angiotensin receptor. (PubMed id 3419518)1, 2 Jackson T.R.... Hanley M.R. (Nature 1988)
    7. Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains. (PubMed id 3708691)1, 2 Young D.... Wigler M. (Cell 1986)
    8. The MAS proto-oncogene is not imprinted in humans. (PubMed id 8661154)1, 9 Riesewijk A.M....Kalscheuer V.M. (Genomics 1996)
    9. Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes. (PubMed id 24583173)1 Premzl M. (Gene 2014)
    10. Control of adipogenesis by the autocrine interplays between angiotensin 1-7/Mas receptor and angiotensin II/AT1 receptor signaling pathways. (PubMed id 23592774)1 Than A....Chen P. (J. Biol. Chem. 2013)
    11. Complete blockade of the vasorelaxant effects of angiotensin-(1-7) and bradykinin in murine microvessels by antagonists of the receptor Mas. (PubMed id 23459756)1 PeirA^ C....Walther T. (J. Physiol. (Lond.) 2013)
    12. Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection. (PubMed id 22003054)1 Zhang T....Adams J.W. (Am. J. Physiol. Heart Circ. Physiol. 2012)
    13. Biosynthetic pathways and the role of the MAS receptor in the effects of Angiotensin-(1-7) in smooth muscles. (PubMed id 22164327)1 Fressatto de Godoy M.A....Rattan S. (Int J Hypertens 2012)
    14. Angiotensin-(1-7)-mediated signaling in cardiomyocytes. (PubMed id 22518286)1 Gomes E.R....Guatimosim S. (Int J Hypertens 2012)
    15. Characterization and significance of ACE2 and Mas receptor in human colon adenocarcinoma. (PubMed id 22048948)1 Bernardi S....Fabris B. (J Renin Angiotensin Aldosterone Syst 2012)
    16. New cardiovascular and pulmonary therapeutic strategies based on the Angiotensin-converting enzyme 2/angiotensin-(1-7)/mas receptor axis. (PubMed id 22319643)1 Ferreira A.J....Santos R.A. (Int J Hypertens 2012)
    17. Therapeutic targeting of the angiotensin-converting enzyme 2/Angiotensin-(1-7)/Mas cascade in the renin-angiotensin system: a patent review. (PubMed id 22510001)1 Ferreira A.J....Santos R.A. (Expert Opin Ther Pat 2012)
    18. Angiotensin converting enzyme 2, Angiotensin-(1-7), and receptor MAS axis in the kidney. (PubMed id 22518283)1 Pinheiro S.V. and SimA/es E Silva A.C. (Int J Hypertens 2012)
    19. (Pro)renin receptors and angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in human aortic valve stenosis. (PubMed id 21316680)1 Peltonen T....Taskinen P. (Atherosclerosis 2011)
    20. Angiotensin-(1-7), its receptor Mas, and the angiotensin-converting enzyme type 2 are expressed in the human ovary. (PubMed id 20674894)1 Reis F.M....Santos R.A. (Fertil. Steril. 2011)
    21. Angiotensin (1-7) and its receptor Mas are expressed in the human testis: implications for male infertility. (PubMed id 20361351)1 Reis A.B....Reis F.M. (J. Mol. Histol. 2010)
    22. Devil and angel in the renin-angiotensin system: ACE-angiotensin II-AT1 receptor axis vs. ACE2-angiotensin-(1-7)-Mas receptor axis. (PubMed id 19461648)1 Iwai M. and Horiuchi M. (Hypertens. Res. 2009)
    23. The vasoactive peptide angiotensin-(1-7), its receptor Mas and the angiotensin-converting enzyme type 2 are expressed in the human endometrium. (PubMed id 19164480)1 Vaz-Silva J....Reis F.M. (Reprod Sci 2009)
    24. Angiotensin metabolites can stimulate receptors of the Mas-related genes family. (PubMed id 18636314)1 Gembardt F....Walther T. (Mol. Cell. Biochem. 2008)
    25. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    26. G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor. (PubMed id 15809376)2 Kostenis E.... Walther T. (Circulation 2005)
    27. An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studies. (PubMed id 15123239)1 Boisguerin P....Volkmer-Engert R. (amp 2004)
    28. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. (PubMed id 12829792)1 Santos R.A....Walther T. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    29. Cell type-specific expression of the Mas proto-oncogene in testis. (PubMed id 11967280)1 Alenina N....Walther T. (J. Histochem. Cytochem. 2002)
    30. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    31. Degeneration of cone photoreceptors induced by expression of the Mas1 protooncogene. (PubMed id 10785460)1 Xu X....Al-Ubaidi M.R. (Exp. Neurol. 2000)
    32. Molecular and cell biology of angiotensin receptors. (PubMed id 1725048)1 Hanley M.R. (J. Cardiovasc. Pharmacol. 1991)
    33. The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action. (PubMed id 2197067)1 Hanley M.R....Goedert M. (Ciba Found. Symp. 1990)
    34. Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements. (PubMed id 3329713)1 Rabin M....Ruddle F.H. (Oncogene Res. 1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4142 HGNC: 6899 AceView: MAS1 Ensembl:ENSG00000130368 euGenes: HUgn4142
    ECgene: MAS1 Kegg: 4142 H-InvDB: MAS1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAS1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAS1 gene:
    Search GeneIP for patents involving MAS1

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