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Aliases for MAS1 Gene

Aliases for MAS1 Gene

  • MAS1 Proto-Oncogene, G Protein-Coupled Receptor 2 3 5
  • MAS1 Oncogene 2 3
  • MAS 3 4
  • Mas-Related G Protein-Coupled Receptor A 3
  • MGRA 3

External Ids for MAS1 Gene

Previous GeneCards Identifiers for MAS1 Gene

  • GC06P159767
  • GC06P160201
  • GC06P160237
  • GC06P160298
  • GC06P160327
  • GC06P157798

Summaries for MAS1 Gene

Entrez Gene Summary for MAS1 Gene

  • This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]

GeneCards Summary for MAS1 Gene

MAS1 (MAS1 Proto-Oncogene, G Protein-Coupled Receptor) is a Protein Coding gene. Among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and peptide hormone binding. An important paralog of this gene is MRGPRX4.

UniProtKB/Swiss-Prot for MAS1 Gene

  • Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.

Gene Wiki entry for MAS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAS1 Gene

Genomics for MAS1 Gene

Regulatory Elements for MAS1 Gene

Enhancers for MAS1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAS1 Gene

Chromosome:
6
Start:
159,906,690 bp from pter
End:
159,916,530 bp from pter
Size:
9,841 bases
Orientation:
Plus strand

Genomic View for MAS1 Gene

Genes around MAS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAS1 Gene

Proteins for MAS1 Gene

  • Protein details for MAS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04201-MAS_HUMAN
    Recommended name:
    Proto-oncogene Mas
    Protein Accession:
    P04201
    Secondary Accessions:
    • E1P5B3
    • Q2TBC9
    • Q6FG47

    Protein attributes for MAS1 Gene

    Size:
    325 amino acids
    Molecular mass:
    37465 Da
    Quaternary structure:
    • Interacts with AGTR1. Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).

neXtProt entry for MAS1 Gene

Proteomics data for MAS1 Gene at MOPED

Post-translational modifications for MAS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAS1 Gene

Domains & Families for MAS1 Gene

Gene Families for MAS1 Gene

Protein Domains for MAS1 Gene

Suggested Antigen Peptide Sequences for MAS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04201

UniProtKB/Swiss-Prot:

MAS_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with MAS1: view

Function for MAS1 Gene

Molecular function for MAS1 Gene

GENATLAS Biochemistry:
MAS1 oncogene (angiotensin receptor), G protein coupled receptor superfamily,imprinted in breast tissue
UniProtKB/Swiss-Prot Function:
Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.

Gene Ontology (GO) - Molecular Function for MAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001595 angiotensin receptor activity ISS --
genes like me logo Genes that share ontologies with MAS1: view
genes like me logo Genes that share phenotypes with MAS1: view

Animal Models for MAS1 Gene

MGI Knock Outs for MAS1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MAS1 Gene

Localization for MAS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAS1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAS1 Gene COMPARTMENTS Subcellular localization image for MAS1 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for MAS1 Gene

Pathways & Interactions for MAS1 Gene

genes like me logo Genes that share pathways with MAS1: view

Interacting Proteins for MAS1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000252660%0d%0a9606.ENSP00000355627%0d%0a
Selected Interacting proteins: ENSP00000252660 P04201-MAS_HUMAN for MAS1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS 3419518
GO:0007283 spermatogenesis IEA --
GO:0008584 male gonad development IEA --
GO:0009653 anatomical structure morphogenesis TAS 8661154
genes like me logo Genes that share ontologies with MAS1: view

No data available for SIGNOR curated interactions for MAS1 Gene

Drugs & Compounds for MAS1 Gene

(5) Drugs for MAS1 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AR234960 Pharma 0
AR244555 Pharma 0
AR305352 Pharma 0
CGEN-856 Pharma 0
CGEN-857 Pharma 0

(1) Additional Compounds for MAS1 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
angiotensin-(1-7)
Full agonist, Agonist
genes like me logo Genes that share compounds with MAS1: view

Transcripts for MAS1 Gene

mRNA/cDNA for MAS1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAS1 Gene

MAS1 oncogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAS1 Gene

No ASD Table

Relevant External Links for MAS1 Gene

GeneLoc Exon Structure for
MAS1
ECgene alternative splicing isoforms for
MAS1

Expression for MAS1 Gene

mRNA expression in normal human tissues for MAS1 Gene

mRNA differential expression in normal tissues according to GTEx for MAS1 Gene

This gene is overexpressed in Brain - Hippocampus (x9.1), Brain - Frontal Cortex (BA9) (x8.7), Brain - Anterior cingulate cortex (BA24) (x7.8), Brain - Cortex (x5.4), and Cervix - Ectocervix (x5.3).

Protein differential expression in normal tissues from HIPED for MAS1 Gene

This gene is overexpressed in Hair follicle (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAS1 Gene



SOURCE GeneReport for Unigene cluster for MAS1 Gene Hs.99900

genes like me logo Genes that share expression patterns with MAS1: view

Protein tissue co-expression partners for MAS1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MAS1 Gene

Orthologs for MAS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAS1 35
  • 84.66 (n)
  • 88.57 (a)
MAS1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAS1 35
  • 86.87 (n)
  • 90.46 (a)
mouse
(Mus musculus)
Mammalia Mas1 35
  • 85.39 (n)
  • 90.43 (a)
Mas1 16
Mas1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAS1 35
  • 99.49 (n)
  • 99.08 (a)
MAS1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mas1 35
  • 84.57 (n)
  • 91.05 (a)
oppossum
(Monodelphis domestica)
Mammalia MAS1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAS1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAS1 35
  • 65.43 (n)
  • 59.26 (a)
MAS1 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
OneToMany
-- 36
  • 29 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494761 35
  • 52.53 (n)
  • 40.47 (a)
Species with no ortholog for MAS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAS1 Gene

ENSEMBL:
Gene Tree for MAS1 (if available)
TreeFam:
Gene Tree for MAS1 (if available)

Paralogs for MAS1 Gene

(8) SIMAP similar genes for MAS1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAS1: view

Variants for MAS1 Gene

Sequence variations from dbSNP and Humsavar for MAS1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs170219 -- 159,908,391(-) TCATC(C/T)TCACA downstream-variant-500B
rs11968301 -- 159,907,637(+) TTTAC(A/G)TAGTC reference, missense
rs220721 -- 159,907,588(-) TTCAC(A/G)ACCAA reference, synonymous-codon
rs220722 -- 159,905,658(-) AATGG(C/T)TCTGG upstream-variant-2KB
rs220723 -- 159,905,535(-) GTTGG(C/T)GAAAC upstream-variant-2KB

Variation tolerance for MAS1 Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.27% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MAS1 Gene

Disorders for MAS1 Gene

UniProtKB/Swiss-Prot

MAS_HUMAN
  • Note=The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells. {ECO:0000269 PubMed:3708691}.

Relevant External Links for MAS1

Genetic Association Database (GAD)
MAS1
Human Genome Epidemiology (HuGE) Navigator
MAS1
Tumor Gene Database (TGDB):
MAS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAS1

No disorders were found for MAS1 Gene.

No data available for MalaCards and Genatlas for MAS1 Gene

Publications for MAS1 Gene

  1. Up-regulation of the angiotensin II type 1 receptor by the MAS proto- oncogene is due to constitutive activation of Gq/G11 by MAS. (PMID: 16611642) Canals M. … Milligan G. (J. Biol. Chem. 2006) 3 4 23 67
  2. The MAS proto-oncogene is not imprinted in humans. (PMID: 8661154) Riesewijk A.M. … Kalscheuer V.M. (Genomics 1996) 3 23
  3. Expression of MAS1 in breast cancer. (PMID: 26080617) Luo Y. … Kuniyasu H. (Cancer Sci. 2015) 3
  4. G Protein-Coupled Receptors Directly Bind Filamin A with High Affinity and Promote Filamin Phosphorylation. (PMID: 26460884) Tirupula K.C. … Karnik S.S. (Biochemistry 2015) 3
  5. MAS promoter regulation: a role for Sry and tyrosine nitration of the KRAB domain of ZNF274 as a feedback mechanism. (PMID: 24128372) Prokop J.W. … Milsted A. (Clin. Sci. 2014) 3

Products for MAS1 Gene

Sources for MAS1 Gene

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