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Aliases for MAS1 Gene

Aliases for MAS1 Gene

  • MAS1 Proto-Oncogene, G Protein-Coupled Receptor 2 3
  • MAS1 Oncogene 2 3
  • MAS 3 4
  • Mas-Related G Protein-Coupled Receptor A 3
  • Proto-Oncogene Mas 3
  • MGRA 3

External Ids for MAS1 Gene

Previous GeneCards Identifiers for MAS1 Gene

  • GC06P159767
  • GC06P160201
  • GC06P160237
  • GC06P160298
  • GC06P160327
  • GC06P157798

Summaries for MAS1 Gene

Entrez Gene Summary for MAS1 Gene

  • This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]

GeneCards Summary for MAS1 Gene

MAS1 (MAS1 Proto-Oncogene, G Protein-Coupled Receptor) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and peptide hormone binding. An important paralog of this gene is MRGPRX4.

UniProtKB/Swiss-Prot for MAS1 Gene

  • Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.

Gene Wiki entry for MAS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAS1 Gene

Genomics for MAS1 Gene

Regulatory Elements for MAS1 Gene

Genomic Location for MAS1 Gene

Start:
159,906,690 bp from pter
End:
159,916,530 bp from pter
Size:
9,841 bases
Orientation:
Plus strand

Genomic View for MAS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAS1 Gene

Proteins for MAS1 Gene

  • Protein details for MAS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04201-MAS_HUMAN
    Recommended name:
    Proto-oncogene Mas
    Protein Accession:
    P04201
    Secondary Accessions:
    • E1P5B3
    • Q2TBC9
    • Q6FG47

    Protein attributes for MAS1 Gene

    Size:
    325 amino acids
    Molecular mass:
    37465 Da
    Quaternary structure:
    • Interacts with AGTR1.

neXtProt entry for MAS1 Gene

Proteomics data for MAS1 Gene at MOPED

Post-translational modifications for MAS1 Gene

  • Glycosylation at Asn5, Asn16, and Asn22
  • Modification sites at PhosphoSitePlus

Other Protein References for MAS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAS1 Gene

Domains for MAS1 Gene

Gene Families for MAS1 Gene

HGNC:
  • GPCRAO :GPCR / Class A : Orphans
IUPHAR :

Protein Domains for MAS1 Gene

Suggested Antigen Peptide Sequences for MAS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04201

UniProtKB/Swiss-Prot:

MAS_HUMAN :
  • P04201
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with MAS1: view

Function for MAS1 Gene

Molecular function for MAS1 Gene

GENATLAS Biochemistry: MAS1 oncogene (angiotensin receptor), G protein coupled receptor superfamily,imprinted in breast tissue
UniProtKB/Swiss-Prot Function: Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.

Gene Ontology (GO) - Molecular Function for MAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001595 angiotensin receptor activity ISS --
GO:0004930 G-protein coupled receptor activity IDA 16611642
GO:0004945 angiotensin type II receptor activity TAS 3419518
GO:0017046 peptide hormone binding IEA --
GO:0042277 peptide binding ISS --
genes like me logo Genes that share ontologies with MAS1: view
genes like me logo Genes that share phenotypes with MAS1: view

Animal Models for MAS1 Gene

MGI Knock Outs for MAS1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for MAS1 Gene

Localization for MAS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAS1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAS1 Gene COMPARTMENTS Subcellular localization image for MAS1 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for MAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 16611642
GO:0005887 integral component of plasma membrane TAS 3419518
GO:0009986 cell surface IEA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with MAS1: view

Pathways for MAS1 Gene

genes like me logo Genes that share pathways with MAS1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for MAS1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000252660%0d%0a9606.ENSP00000355627%0d%0a
Selected Interacting proteins: ENSP00000252660 P04201-MAS_HUMAN for MAS1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 3419518
GO:0007250 activation of NF-kappaB-inducing kinase activity IEA --
GO:0007283 spermatogenesis IEA --
GO:0008283 cell proliferation TAS 3419518
genes like me logo Genes that share ontologies with MAS1: view

Compounds for MAS1 Gene

(1) IUPHAR Ligand for MAS1 Gene

Ligand Type Action Affinity Pubmed IDs
angiotensin-(1-7) Agonist Full agonist 9.4
genes like me logo Genes that share compounds with MAS1: view

Transcripts for MAS1 Gene

mRNA/cDNA for MAS1 Gene

(5) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAS1 Gene

MAS1 oncogene:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAS1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAS1 Gene

No ASD Table

Relevant External Links for MAS1 Gene

GeneLoc Exon Structure for
MAS1
ECgene alternative splicing isoforms for
MAS1

Expression for MAS1 Gene

mRNA expression in normal human tissues for MAS1 Gene

mRNA differential expression in normal tissues according to GTEx for MAS1 Gene

This gene is overexpressed in Brain - Hippocampus (9.1), Brain - Frontal Cortex (BA9) (8.7), Brain - Anterior cingulate cortex (BA24) (7.8), Brain - Cortex (5.4), and Cervix - Ectocervix (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MAS1 Gene

SOURCE GeneReport for Unigene cluster for MAS1 Gene Hs.99900

genes like me logo Genes that share expressions with MAS1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MAS1 Gene

Orthologs for MAS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAS1 35
  • 99.49 (n)
  • 99.08 (a)
MAS1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAS1 35
  • 84.66 (n)
  • 88.57 (a)
MAS1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAS1 35
  • 86.87 (n)
  • 90.46 (a)
mouse
(Mus musculus)
Mammalia Mas1 35
  • 85.39 (n)
  • 90.43 (a)
Mas1 16
Mas1 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAS1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAS1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mas1 35
  • 84.57 (n)
  • 91.05 (a)
chicken
(Gallus gallus)
Aves MAS1 35
  • 65.43 (n)
  • 59.26 (a)
MAS1 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
OneToMany
-- 36
  • 29 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494761 35
  • 52.53 (n)
  • 40.47 (a)
Species with no ortholog for MAS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAS1 Gene

ENSEMBL:
Gene Tree for MAS1 (if available)
TreeFam:
Gene Tree for MAS1 (if available)

Paralogs for MAS1 Gene

Paralogs for MAS1 Gene

Selected SIMAP similar genes for MAS1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAS1: view

Variants for MAS1 Gene

Sequence variations from dbSNP and Humsavar for MAS1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs170219 -- 159,908,391(-) TCATC(C/T)TCACA downstream-variant-500B
rs220721 -- 159,907,588(-) TTCAC(A/G)ACCAA reference, synonymous-codon
rs220722 -- 159,905,658(-) AATGG(C/T)TCTGG upstream-variant-2KB
rs220723 -- 159,905,535(-) GTTGG(C/T)GAAAC upstream-variant-2KB
rs220724 -- 159,905,236(-) CTCCC(C/T)CCACA upstream-variant-2KB

Relevant External Links for MAS1 Gene

HapMap Linkage Disequilibrium report
MAS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAS1 Gene

Disorders for MAS1 Gene

UniProtKB/Swiss-Prot

MAS_HUMAN
  • Note=The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells.

Relevant External Links for MAS1

Genetic Association Database (GAD)
MAS1
Human Genome Epidemiology (HuGE) Navigator
MAS1
Tumor Gene Database (TGDB):
MAS1
genes like me logo Genes that share disorders with MAS1: view

Publications for MAS1 Gene

  1. Up-regulation of the angiotensin II type 1 receptor by the MAS proto- oncogene is due to constitutive activation of Gq/G11 by MAS. (PMID: 16611642) Canals M. … Milligan G. (J. Biol. Chem. 2006) 3 4 23
  2. The MAS proto-oncogene is not imprinted in humans. (PMID: 8661154) Riesewijk A.M. … Kalscheuer V.M. (Genomics 1996) 3 23
  3. The mas oncogene encodes an angiotensin receptor. (PMID: 3419518) Jackson T.R. … Hanley M.R. (Nature 1988) 3 4
  4. Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains. (PMID: 3708691) Young D. … Wigler M. (Cell 1986) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MAS1 Gene

Sources for MAS1 Gene

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