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Aliases for MAS1 Gene

Aliases for MAS1 Gene

  • MAS1 Proto-Oncogene, G Protein-Coupled Receptor 2 3 5
  • MAS1 Oncogene 2 3
  • MAS 3 4
  • Mas-Related G Protein-Coupled Receptor A 3
  • Proto-Oncogene Mas 3
  • MGRA 3

External Ids for MAS1 Gene

Previous GeneCards Identifiers for MAS1 Gene

  • GC06P159767
  • GC06P160201
  • GC06P160237
  • GC06P160298
  • GC06P160327
  • GC06P157798

Summaries for MAS1 Gene

Entrez Gene Summary for MAS1 Gene

  • This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]

GeneCards Summary for MAS1 Gene

MAS1 (MAS1 Proto-Oncogene, G Protein-Coupled Receptor) is a Protein Coding gene. Among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and peptide hormone binding. An important paralog of this gene is MRGPRX2.

UniProtKB/Swiss-Prot for MAS1 Gene

  • Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.

Gene Wiki entry for MAS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAS1 Gene

Genomics for MAS1 Gene

Regulatory Elements for MAS1 Gene

Enhancers for MAS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F159987 1.6 FANTOM5 Ensembl ENCODE 13.9 +82.4 82419 3.4 HDGF WRNIP1 GATA2 CBX5 ZNF143 JUNB REST CREB3 MEF2D SMARCA4 IGF2R MAS1 WTAP ENSG00000236823 SOD2 SLC22A1 AIRN
GH06F159975 1.8 FANTOM5 Ensembl ENCODE 12.2 +74.6 74593 10.6 HDGF PKNOX1 ATF1 WRNIP1 SIN3A ARID4B FEZF1 ZNF48 ZNF2 YY1 IGF2R WTAP MAS1 SOD2 ENSG00000236823 SLC22A1 AIRN
GH06F159966 1.4 Ensembl ENCODE 10.7 +62.0 62038 5.5 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 FOS IGF2R MAS1 ENSG00000236823 SLC22A1 LOC729603 LOC105378087
GH06F159958 1.4 FANTOM5 Ensembl ENCODE 10.6 +53.2 53210 1.9 ZMYM3 BACH1 RELA ZNF316 GATA2 NFE2 MAFK L3MBTL2 RNF2 MAFG MAS1 ENSG00000236823 LOC729603 SOD2 WTAP IGF2R LOC105378087
GH06F159929 1.1 Ensembl ENCODE 12.3 +23.4 23356 1.2 TBP HDAC1 TBL1XR1 WRNIP1 ZNF133 FEZF1 ZNF48 CHAMP1 CBX5 CREM MAS1 ENSG00000236823 LOC105378087 IGF2R
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAS1 Gene

Chromosome:
6
Start:
159,906,690 bp from pter
End:
159,916,530 bp from pter
Size:
9,841 bases
Orientation:
Plus strand

Genomic View for MAS1 Gene

Genes around MAS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAS1 Gene

Proteins for MAS1 Gene

  • Protein details for MAS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04201-MAS_HUMAN
    Recommended name:
    Proto-oncogene Mas
    Protein Accession:
    P04201
    Secondary Accessions:
    • E1P5B3
    • Q2TBC9
    • Q6FG47

    Protein attributes for MAS1 Gene

    Size:
    325 amino acids
    Molecular mass:
    37465 Da
    Quaternary structure:
    • Interacts with AGTR1. Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).

neXtProt entry for MAS1 Gene

Post-translational modifications for MAS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAS1 Gene

Domains & Families for MAS1 Gene

Gene Families for MAS1 Gene

Protein Domains for MAS1 Gene

Suggested Antigen Peptide Sequences for MAS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04201

UniProtKB/Swiss-Prot:

MAS_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with MAS1: view

Function for MAS1 Gene

Molecular function for MAS1 Gene

GENATLAS Biochemistry:
MAS1 oncogene (angiotensin receptor), G protein coupled receptor superfamily,imprinted in breast tissue
UniProtKB/Swiss-Prot Function:
Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.

Gene Ontology (GO) - Molecular Function for MAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001595 angiotensin receptor activity ISS --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IDA 16611642
GO:0004945 angiotensin type II receptor activity TAS 3419518
GO:0005515 protein binding IPI 26460884
genes like me logo Genes that share ontologies with MAS1: view
genes like me logo Genes that share phenotypes with MAS1: view

Animal Models for MAS1 Gene

MGI Knock Outs for MAS1:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MAS1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MAS1 Gene

Localization for MAS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAS1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAS1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for MAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA,IDA 16611642
GO:0005887 integral component of plasma membrane TAS 3419518
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MAS1: view

Pathways & Interactions for MAS1 Gene

genes like me logo Genes that share pathways with MAS1: view

Interacting Proteins for MAS1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000252660%0d%0a9606.ENSP00000355627%0d%0a
Selected Interacting proteins: ENSP00000252660 P04201-MAS_HUMAN for MAS1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for MAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS 3419518
GO:0007250 activation of NF-kappaB-inducing kinase activity IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with MAS1: view

No data available for SIGNOR curated interactions for MAS1 Gene

Drugs & Compounds for MAS1 Gene

(5) Drugs for MAS1 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AR234960 Pharma 0
AR244555 Pharma 0
AR305352 Pharma 0
CGEN-856 Pharma 0
CGEN-857 Pharma 0

(1) Additional Compounds for MAS1 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
angiotensin-(1-7)
Full agonist, Agonist
genes like me logo Genes that share compounds with MAS1: view

Transcripts for MAS1 Gene

mRNA/cDNA for MAS1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAS1 Gene

MAS1 oncogene:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MAS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAS1 Gene

No ASD Table

Relevant External Links for MAS1 Gene

GeneLoc Exon Structure for
MAS1
ECgene alternative splicing isoforms for
MAS1

Expression for MAS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAS1 Gene

mRNA differential expression in normal tissues according to GTEx for MAS1 Gene

This gene is overexpressed in Brain - Hippocampus (x9.1), Brain - Frontal Cortex (BA9) (x8.7), Brain - Anterior cingulate cortex (BA24) (x7.8), Brain - Cortex (x5.4), and Cervix - Ectocervix (x5.3).

Protein differential expression in normal tissues from HIPED for MAS1 Gene

This gene is overexpressed in Hair follicle (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAS1 Gene



Protein tissue co-expression partners for MAS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAS1 Gene:

MAS1

SOURCE GeneReport for Unigene cluster for MAS1 Gene:

Hs.99900
genes like me logo Genes that share expression patterns with MAS1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MAS1 Gene

Orthologs for MAS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAS1 34 35
  • 99.49 (n)
oppossum
(Monodelphis domestica)
Mammalia MAS1 35
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAS1 34
  • 86.87 (n)
mouse
(Mus musculus)
Mammalia Mas1 34 16 35
  • 85.39 (n)
cow
(Bos Taurus)
Mammalia MAS1 34 35
  • 84.66 (n)
rat
(Rattus norvegicus)
Mammalia Mas1 34
  • 84.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAS1 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAS1 34 35
  • 65.43 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 35 (a)
OneToMany
-- 35
  • 29 (a)
OneToMany
-- 35
  • 25 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494761 34
  • 52.53 (n)
Species where no ortholog for MAS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAS1 Gene

ENSEMBL:
Gene Tree for MAS1 (if available)
TreeFam:
Gene Tree for MAS1 (if available)

Paralogs for MAS1 Gene

(8) SIMAP similar genes for MAS1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAS1: view

Variants for MAS1 Gene

Sequence variations from dbSNP and Humsavar for MAS1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs111869113 -- 159,908,510(+) TAAAG(-/CACA)CACAC downstream-variant-500B
rs111927070 -- 159,907,000(+) CCCAC(A/G/T)AACAT reference, synonymous-codon
rs112564811 -- 159,907,949(+) GGAAG(C/T)TGTGG utr-variant-3-prime
rs112894922 -- 159,906,384(+) AATAT(G/T)AAACC upstream-variant-2KB
rs115510555 -- 159,905,565(+) CCAGG(A/G)TCCAG upstream-variant-2KB

Variation tolerance for MAS1 Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAS1 Gene

Disorders for MAS1 Gene

UniProtKB/Swiss-Prot

MAS_HUMAN
  • Note=The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells. {ECO:0000269 PubMed:3708691}.

Relevant External Links for MAS1

Genetic Association Database (GAD)
MAS1
Human Genome Epidemiology (HuGE) Navigator
MAS1
Tumor Gene Database (TGDB):
MAS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAS1

No disorders were found for MAS1 Gene.

No data available for MalaCards and Genatlas for MAS1 Gene

Publications for MAS1 Gene

  1. Up-regulation of the angiotensin II type 1 receptor by the MAS proto- oncogene is due to constitutive activation of Gq/G11 by MAS. (PMID: 16611642) Canals M. … Milligan G. (J. Biol. Chem. 2006) 3 4 22 64
  2. G Protein-Coupled Receptors Directly Bind Filamin A with High Affinity and Promote Filamin Phosphorylation. (PMID: 26460884) Tirupula K.C. … Karnik S.S. (Biochemistry 2015) 3 4 64
  3. Interactions among related genes of renin-angiotensin system associated with type 2 diabetes. (PMID: 20592051) Yang J.K. … Ma Y.H. (Diabetes Care 2010) 3 46 64
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for MAS1 Gene

Sources for MAS1 Gene

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