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MAS1 Gene

protein-coding   GIFtS: 63

GC06P160298
MAS1 oncogene
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
MAS 2, 3
MGC119966 2
OTTHUMP00000017535 2
Descriptions
MAS1 oncogene 2
External Ids
HGNC: 68991
Entrez Gene: 41422
UniProtKB: P042013
Ensembl: ENSG000001303687
Search outside databases for aliases for MAS1 gene

Previous GC identifers: GC06P159767 GC06P160201 GC06P160237

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MAS1:
The structure of the MAS1 product indicates that it belongs to the class of receptors that are
coupled to GTP-binding proteins and share a conserved structural motif, which is described as a
'7-transmembrane segment' following the prediction that these hydrophobic segments form
membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated,
modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.
[provided by RefSeq]

Gene Wiki entry for MAS1
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the MAS1 gene  

Entrez Gene cytogenetic band: 6q25.3-q26   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q24-q27

MAS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P160298:     (about GC identifiers)

Start:
160,247,964 bp from pter
End:
160,249,098 bp from pter
Size:
1,135 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000006.10  NT_007422.13  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MAS_HUMAN, P04201 (See protein sequence)
Recommended Name: MAS proto-oncogene  
Size: 325 amino acids; 37465 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Caution: Was originally (PubMed:3419518) thought to be a receptor for angiotensin II
Secondary accessions: Q2TBC9 Q6FG47

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_002368.1  

    ENSEMBL proteins: 
    ENSP00000252660 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (MAS1)
    Human Recombinant Proteins from Abnova (MAS1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0005887 integral to plasma membrane TAS3419518
    About this table

    Antibodies for MAS1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for MAS1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (MAS1), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Novus Biologicals Antibody for MAS1

    Assays for MAS1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_supfam
     IPR000820 Mas_TM
     IPR000276 7TM_GPCR_Rhodpsn


       GeneDecks  MAS1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P04201

    ProtoNet protein and cluster: P04201

    1 Blocks protein family: IPB000820 Mas oncogene signature

    UniProtKB/Swiss-Prot: MAS_HUMAN, P04201
    Similarity: Belongs to the G-protein coupled receptor 1 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (MAS1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (MAS1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002377

                  Applied Biosystems Silencer® siRNAs for MAS1

                  Sigma-Aldrich siRNA and siRNA Panels for MAS1  
                         Sigma-Aldrich shRNA Panels and shRNA for MAS1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for MAS1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002377
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002377
                                     untagged cDNA clone in CMV expression vector: NM_002377 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_002377

    Genatlas biochemistry entry for MAS1:
    MAS1 oncogene (angiotensin receptor), G protein coupled receptor superfamily,imprinted in breast
    tissue

    2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mas1):

    behavior/neurologicalnervous system

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity IEA--
    GO:0004930 G-protein coupled receptor activity TAS3419518
    GO:0004945 angiotensin type II receptor activity TAS3419518
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for MAS1
     Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

       GeneDecks  MAS1 for the pathways selected above  
    About GeneDecksing

    2 Kegg Pathways  (Kegg details for MAS1):
     hsa04080 Neuroactive ligand-receptor interaction
     hsa04614 Renin-angiotensin system

       GeneDecks  MAS1 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  MAS1 


    5/8 Interacting proteins for MAS1 (ENSP000002526603) via UniProtKB, MINT, and/or STRING (see all 8 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RENENSP000002721903STRING (score=.951)
    AGTENSP000003556273STRING (score=.845)
    IGF2RENSP000003494373STRING (score=.838)
    MOSENSP000003107223STRING (score=.75)
    ACE2ENSP000002525193STRING (score=.748)
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165 signal transduction IEA--
    GO:0007186 G-protein coupled receptor protein signaling pathway TAS3419518
    GO:0008283 cell proliferation TAS3419518
    GO:0009653 anatomical structure morphogenesis TAS8661154
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for MAS1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (MAS1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (MAS1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002377

                  Sigma-Aldrich siRNA and siRNA Panels for MAS1  
                         Sigma-Aldrich shRNA Panels and shRNA for MAS1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_002377  

    REFSEQ mRNAs for MAS1 gene: 

    NM_002377.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_002377  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002377
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002377
                                     untagged cDNA clone in CMV expression vector: NM_002377 

    Additional cDNA sequence: 

    BC069142.1 BC069581.1 BC110454.2 CR542261.1 M13150.1 

    1 DOTS entry:

    DT.40119864 

    5 AceView cDNA sequences:

    NM_002377 BC069142 BC069581 M13150 CR542261 

    highest scoring ESTs for MAS1:

    M13150 BC069142 BC069581 CR542261 NM_002377 BC110454 CO915687 CO926509 CO930099 CO930118 

    Unigene Cluster for MAS1:

    MAS1 oncogene
    Hs.99900  [show with all ESTs]
    Unigene Representative Sequence: M13150


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000252660  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    MAS1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for MAS1

    1 / 2 / 3

    3 probe-sets matching MAS1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    31549_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 M13150 1.00 1.00 1.00 1

    208210_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002377 0.60 1.00 0.82 1

    208210_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AGATACTAAT

    SOURCE GeneReport for Unigene cluster: Hs.99900

    Expression variation in blood from EXPOLDB for MAS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for MAS1 gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    MAS11   -- MAS1 oncogene 85.09(n)
    88.16(a)
    484066  XM_850026.1  XP_855119.1 
    chimpanzee
    (Pan troglodytes)
    MAS11   -- MAS1 oncogene 99.49(n)
    99.08(a)
    472176  XM_527553.2  XP_527553.1 
    cow
    (Bos taurus)
    MAS11   -- MAS1 oncogene 83.59(n)
    87.38(a)
    782151  XM_001250740.1  XP_001250741.1 
    rat
    (Rattus norvegicus)
    Mas11   -- MAS1 oncogene 84.57(n)
    91.05(a)
    25153  NM_012757.2  NP_036889.1 
    mouse
    (Mus musculus)
    Mas11, 5 17 (7.45 cM)5
    MAS1 oncogene1, 5 85.39(n)1
    90.43(a)1
    171711  NM_008552.31  NP_032578.21 
     AJ2498955  AK0302615  (see all 12)
    About this table        Species with no ortholog for MAS1

    ENSEMBL Gene Tree for MAS1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for MAS1 gene
    MRGPRD2  MRGPRF2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/27 NCBI SNPs in MAS1 are shown (see all 27 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 31)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs2207231,2
    A,C,F,H160246557(-) GTTGGC/TGAAAC 1 -- ng5115Minor allele frequency- N:0.00NA EA EU WA 1182
    rs2207241,2
    A,C,F,H160246258(-) CTCCCT/CCCACA 1 -- ng51 trp33Minor allele frequency- C:0.48EU EA 272
    rs1702191,2
    A,C,F,H160249413(-) TCATCC/TTCACA 1 -- ng314Minor allele frequency- T:0.46EU EA WA 418
    rs2207221,2
    C,F,H160246680(-) AATGGC/TTCTGG 1 -- ng518Minor allele frequency- T:0.03EU EA WA 834
    --
    rs2207251,2
    C,F160245979(-) agacaC/Tgaagg 1 -- ng513Minor allele frequency- T:0.01NA 142
    rs119683011,2
    C,H160248659(+) TTTACA/GTAGTC 1 I/V mis1 ese34Minor allele frequency- G:0.00EU EA WA 418
    rs93651121,2
    H160246030(+) CACTAT/AGGACG 1 -- ng514Minor allele frequency- A:0.00EU EA WA 418
    rs2207211,2
    A,C,F,H,O160248610(-) TTCACG/AACCAA 1 V/V syn115Minor allele frequency- A:0.46EA NA MN EU WA 1228
    --
    rs571915441,2
    --160249556(+) ACACA-/CACAC 
     ACACACA
    GCTCT
    1 -- ng310--------
    --
    rs105547011,2
    --160249542(+) acaca-/CAcacac 1 -- ng310--------
    About this table

    HapMap Linkage Disequilibrium images for MAS1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 165180

    UniProtKB/Swiss-Prot: MAS_HUMAN, P04201
  • The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells
  • Human Genome Epidemiology Navigator: MAS1 (1 document)
    Tumor Gene Database: MAS1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/19 PubMed articles for MAS1 gene (see all 19 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 4142 HGNC: 6899 AceView: MAS1 Ensembl:ENSG00000130368 euGenes: HUgn4142
    ECgene: MAS1 H-InvDB: MAS1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for MAS1 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for MAS1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for MAS1 Antibodies for MAS1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for MAS1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for MAS1

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