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Aliases for MARVELD3 Gene

Aliases for MARVELD3 Gene

  • MARVEL Domain Containing 3 2 3
  • MARVEL (Membrane-Associating) Domain Containing 3 2 3
  • MRVLDC3 3 4
  • MARVEL Domain-Containing Protein 3 3
  • MARVD3 3

External Ids for MARVELD3 Gene

Previous Symbols for MARVELD3 Gene

  • MRVLDC3

Summaries for MARVELD3 Gene

GeneCards Summary for MARVELD3 Gene

MARVELD3 (MARVEL Domain Containing 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MARVELD3 Gene

  • As a component of tight junctions, plays a role in paracellular ion conductivity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARVELD3 Gene

Genomics for MARVELD3 Gene

Genomic Location for MARVELD3 Gene

Start:
71,626,153 bp from pter
End:
71,642,114 bp from pter
Size:
15,962 bases
Orientation:
Plus strand

Genomic View for MARVELD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARVELD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARVELD3 Gene

Regulatory Elements for MARVELD3 Gene

Proteins for MARVELD3 Gene

  • Protein details for MARVELD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A59-MALD3_HUMAN
    Recommended name:
    MARVEL domain-containing protein 3
    Protein Accession:
    Q96A59
    Secondary Accessions:
    • A8K820
    • H3BQM5
    • Q96MJ4

    Protein attributes for MARVELD3 Gene

    Size:
    401 amino acids
    Molecular mass:
    44911 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MARVELD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARVELD3 Gene

Proteomics data for MARVELD3 Gene at MOPED

Post-translational modifications for MARVELD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MARVELD3 Gene

No data available for DME Specific Peptides for MARVELD3 Gene

Domains for MARVELD3 Gene

Protein Domains for MARVELD3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

MALD3_HUMAN
Domain:
  • Contains 1 MARVEL domain.:
    • Q96A59
genes like me logo Genes that share domains with MARVELD3: view

No data available for Gene Families for MARVELD3 Gene

Function for MARVELD3 Gene

Molecular function for MARVELD3 Gene

UniProtKB/Swiss-Prot Function: As a component of tight junctions, plays a role in paracellular ion conductivity.

Gene Ontology (GO) - Molecular Function for MARVELD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20164257
GO:0031435 mitogen-activated protein kinase kinase kinase binding IDA 24567356
genes like me logo Genes that share ontologies with MARVELD3: view

Phenotypes for MARVELD3 Gene

GenomeRNAi human phenotypes for MARVELD3:
genes like me logo Genes that share phenotypes with MARVELD3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MARVELD3 Gene

Localization for MARVELD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARVELD3 Gene

Membrane; Multi-pass membrane protein. Cell junction, tight junction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MARVELD3 Gene COMPARTMENTS Subcellular localization image for MARVELD3 gene
Compartment Confidence
plasma membrane 3
nucleus 2

Gene Ontology (GO) - Cellular Components for MARVELD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005923 bicellular tight junction IDA 20028514
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IDA 20164257
genes like me logo Genes that share ontologies with MARVELD3: view

Pathways for MARVELD3 Gene

SuperPathways for MARVELD3 Gene

No Data Available

Interacting Proteins for MARVELD3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000299952%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000299952 for MARVELD3 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for MARVELD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006970 response to osmotic stress IMP 24567356
GO:0010633 negative regulation of epithelial cell migration IMP 24567356
GO:0045216 cell-cell junction organization IMP 20164257
GO:0046329 negative regulation of JNK cascade IMP 24567356
GO:0050680 negative regulation of epithelial cell proliferation IMP 24567356
genes like me logo Genes that share ontologies with MARVELD3: view

No data available for Pathways by source for MARVELD3 Gene

Transcripts for MARVELD3 Gene

Unigene Clusters for MARVELD3 Gene

MARVEL domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MARVELD3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6
SP1: - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: -

Relevant External Links for MARVELD3 Gene

GeneLoc Exon Structure for
MARVELD3
ECgene alternative splicing isoforms for
MARVELD3

Expression for MARVELD3 Gene

mRNA expression in normal human tissues for MARVELD3 Gene

mRNA differential expression in normal tissues according to GTEx for MARVELD3 Gene

This gene is overexpressed in Colon - Transverse (12.5), Small Intestine - Terminal Ileum (7.3), Pancreas (7.1), Kidney - Cortex (4.4), and Minor Salivary Gland (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MARVELD3 Gene

SOURCE GeneReport for Unigene cluster for MARVELD3 Gene Hs.513706

genes like me logo Genes that share expressions with MARVELD3: view

Orthologs for MARVELD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARVELD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARVELD3 37
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MARVELD3 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MARVELD3 36
  • 79.91 (n)
  • 72.6 (a)
MARVELD3 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Marveld3 36
  • 77.13 (n)
  • 69.68 (a)
Marveld3 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MARVELD3 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MARVELD3 37
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves MARVELD3 37
  • 27 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MARVELD3 37
  • 33 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10038 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7140 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
marveld3 36
  • 53.84 (n)
  • 45.24 (a)
MARVELD3 37
  • 34 (a)
OneToOne
Species with no ortholog for MARVELD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARVELD3 Gene

ENSEMBL:
Gene Tree for MARVELD3 (if available)
TreeFam:
Gene Tree for MARVELD3 (if available)

Paralogs for MARVELD3 Gene

No data available for Paralogs for MARVELD3 Gene

Variants for MARVELD3 Gene

Sequence variations from dbSNP and Humsavar for MARVELD3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs979789 -- 71,632,215(-) CGCTT(C/T)GCAGT intron-variant
rs979790 -- 71,632,082(-) CATGT(A/T)AATGG intron-variant
rs1056303 -- 71,636,163(+) AAGTT(C/T)TTTGC intron-variant, utr-variant-3-prime
rs1345868 -- 71,635,721(-) GTGTG(G/T)AAAAA intron-variant, utr-variant-3-prime
rs2303225 -- 71,640,979(-) CTTCC(C/G)GGCTG reference, synonymous-codon, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MARVELD3 Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
esv2597921 CNV Deletion 19546169
esv2116823 CNV Deletion 18987734

Relevant External Links for MARVELD3 Gene

HapMap Linkage Disequilibrium report
MARVELD3

Disorders for MARVELD3 Gene

No disorders were found for MARVELD3 Gene.

No data available for UniProtKB/Swiss-Prot for MARVELD3 Gene

Publications for MARVELD3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4
  3. Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family. (PMID: 20028514) Steed E. … Matter K. (BMC Cell Biol. 2009) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for MARVELD3 Gene

Sources for MARVELD3 Gene

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