MARVELD3 Gene
protein-coding GIFtS : 45
GCID: GC16 P071661
MARVEL domain containing 3 (Previous name: MARVEL (membrane-associating) domain containing 3 ) (Previous symbol: MRVLDC3 )
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Aliasesfor MARVELD3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases MARVEL Domain Containing 3 1 2 MRVLDC31 2 3 MARVEL (Membrane-Associating) Domain Containing 31 2 MARVD32 MARVEL Domain-Containing Protein 32
Export aliases for MARVELD3 gene to outside databases Previous GC identifers: GC16P070217 GC16P057428
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Summariesfor MARVELD3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: MALD3_HUMAN, Q96A59 Function : As a component of tight junctions, plays a role in paracellular ion conductivity
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Genomic Viewsfor MARVELD3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000016.9 NC_018927.1 NT_010498.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MARVELD3 gene promoter: USF1 p53 Cdc5 HNF-1A E47 POU2F1 USF-1 POU2F1a HNF-1 MRF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for MARVELD3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARVELD3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 16q22.2 Ensembl cytogenetic band: 16q22.2 HGNC cytogenetic band: 16q22.2 MARVELD3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16P071661: view genomic region
(about GC identifiers )
Start:
71,660,064 bp from pter
End:
71,676,017 bp from pter
Size:
15,954 bases
Orientation:
plus strand
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Proteinsfor MARVELD3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MALD3_HUMAN, Q96A59 (See
protein sequence )Recommended Name: MARVEL domain-containing protein 3 Size : 401 amino acids; 44911 Da
Subcellular location : Membrane; Multi-pass membrane protein (Potential). Cell junction, tight junction
Secondary accessions : A8K820 Q96MJ4Alternative splicing : 2 isoforms : Q96A59-1 Q96A59-2 (No experimental confirmation available. Ref.1 (BAB71294) sequence is in conflict in position: 388:Y->H)Explore the universe of human proteins at neXtProt for MARVELD3: NX_Q96A59 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96A59 MARVELD3 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (3 alternative transcripts):
NP_001017967.2 NP_001258258.1 NP_443090.3 ENSEMBL proteins: ENSP00000462555 ENSP00000455845 ENSP00000268485 ENSP00000299952 ENSP00000455814 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005923 tight junction
IDA -- GO:0016021 integral to membrane
IEA --
MARVELD3 for ontologies About GeneDecksing MARVELD3 Antibody Products: Assay Products for MARVELD3:
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Protein
Domains / Familiesfor MARVELD3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MARVELD3 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q96A59 ProtoNet protein and cluster: Q96A59
1 Blocks protein family : IPB008253 Marvel UniProtKB/Swiss-Prot: MALD3_HUMAN, Q96A59 Similarity : Contains 1 MARVEL domain
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Functionfor MARVELD3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: MALD3_HUMAN, Q96A59 Function : As a component of tight junctions, plays a role in paracellular ion conductivity
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MARVELD3 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MARVELD3 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): MARVELD3 (NM_001017967 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MARVELD3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MARVELD3
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARVELD3
1 GenomeRNAi human phenotype for MARVELD3 :
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Pathways & Interactionsfor MARVELD3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MARVELD3 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for MARVELD3 (ENSP00000299952 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0045216 cell-cell junction organization
IMP --
MARVELD3 for ontologies About GeneDecksing
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Drugs & Compoundsfor MARVELD3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for MARVELD3 Search CenterWatch for drugs/clinical trials and news about MARVELD3 / MALD3
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Transcriptsfor MARVELD3 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MARVELD3 gene (3 alternative transcripts): NM_001017967.3 NM_001271329.1 NM_052858.4 Unigene Cluster for MARVELD3:
MARVEL domain containing 3 Hs.513706 [show with all ESTs ] Unigene Representative Sequence: NM_052858 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000567566 (uc002fas.1 ) ENST00000565261 ENST00000268485 (uc002fat.3 )ENST00000299952 (uc002fau.3 uc010cge.3 ) ENST00000567501 ENST00000561682 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MARVELD3 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MARVELD3 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): MARVELD3 (NM_001017967 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MARVELD3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MARVELD3
Additional cDNA sequence: AK056842.1 AK292185.1 AK307585.1 BC005052.1 BC011893.2 BC013376.2
6 DOTS entries : DT.70104767 DT.308215
DT.65288550 DT.70103879 DT.40237630 DT.102831826 24/40 AceView cDNA sequences (see all 40 ):
BQ417438 AA807934 BM847497 BP359663 AA075048 BQ287981 BE797382 BQ130613 BM746459 BM784353 BX109314 BC005052 BP358164 BX339918 AK056842 BM742281 AA553974 AI744740 BC011893 AW515153 NM_052858 BX348391 BC013376 BM923622 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for MARVELD3 About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 SP1 :   -   -     -           SP2 :     -     -   -   -   -     SP3 :     -     -           SP4 :         -           SP5 :     -              
ECgene alternative splicing isoforms for MARVELD3
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Expression for MARVELD3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MARVELD3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image MARVELD3 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 2 LifeMap Cells Name Category ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See MARVELD3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MARVELD3 SOURCE GeneReport for Unigene cluster: Hs.513706 SABiosciences Custom PCR Arrays for MARVELD3 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MARVELD3Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat MARVELD3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MARVELD3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MARVELD3 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARVELD3
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Orthologsfor MARVELD3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for MARVELD3 gene from 4/11 species (see all 11 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
MARVELD31
MARVEL domain containing 3
46.53(n) 38.39(a)
 
420903 XM_418989.1 XP_418989.1
lizard (Anolis carolinensis)
Reptilia
MARVELD36
--
41(a)
1 ↔ 1
GL343265.1(116067-117239)
African clawed frog (Xenopus laevis)
Amphibia
Xl.100382
Xenopus laevis transcribed sequence with moderate similarity more
79.69(n)
 
BG487335.1
zebrafish (Danio rerio)
Actinopterygii
BC055662.12
--
72.35(n)
 
393501 BC055662.1
Species with no ortholog for MARVELD3 ENSEMBL Gene Tree for MARVELD3 (if available)TreeFam Gene Tree for MARVELD3 (if available)
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Paralogsfor MARVELD3 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor MARVELD3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 16 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MARVELD3 (71660064 - 71676017 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for MARVELD3 2 CNVs : 43931 102326
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MARVELD3
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Disorders
/ Diseasesfor MARVELD3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MARVELD3 for disorders About GeneDecksing
OMIM gene information: 614094
OMIM disorders : --1 disease for MARVELD3 : About MalaCards pancreatitis Export disorders for MARVELD3 gene to outside databases
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Publicationsfor MARVELD3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MARVELD3 gene, integrated from 9 sources (see all 13 ): (articles sorted by number of sources associating them with MARVELD3) Utopia : connect your pdf to the dynamic world of online information
Identification of MarvelD3 as a tight junction-associ ated transmembrane protein of the occludin family. (PubMed id 20028514) 1 , 2 Steed E....Matter K. (2009) The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553) 1 , 2 Martin J.... Pennacchio L.A. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Genome-wide association study indicates two novel resi stance loci for severe malaria. (PubMed id 22895189) 1 Timmann C....Horstmann R.D. (2012) Downregulation of tight junction-associated MARVEL pr otein marvelD3 during epithelial-mesenchymal transition in human pancreatic can cer cells. (PubMed id 21763689) 1 Kojima T....Sawada N. (2011) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Tight junction-associated MARVEL proteins marveld3, t ricellulin, and occludin have distinct but overlapping functions. (PubMed id 20164257) 1 Raleigh D.R....Turner J.R. (2010) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) Transcriptome analysis of human gastric cancer. (PubMed id 16341674) 1 Oh J.H....Kim N.S. (2005)
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External Searches for MARVELD3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MARVELD3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MARVELD3 gene
(According to HUGE )
About This Section --
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Specialized Databases showing MARVELD3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for MARVELD3 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MARVELD3 gene: Search GeneIP for patents involving MARVELD3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MARVELD3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for MARVELD3 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for MARVELD3 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MARVELD3 OriGene Protein Over-expression Lysate for MARVELD3 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MARVELD3 OriGene 3'-UTR Clone for MARVELD3 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MARVELD3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MARVELD3 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MARVELD3 OriGene Custom Protein Services for MARVELD3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MARVELD3 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MARVELD3 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARVELD3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MARVELD3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MARVELD3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MARVELD3
MARVELD3 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARVELD3
Search ThermoFisher Antibodies for MARVELD3
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MARVELD3
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Aliases for MARVELD3
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Disorders / Diseases for MARVELD3
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Drugs / Compounds for MARVELD3
Expression for MARVELD3
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