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MARVELD2 Gene

protein-coding   GIFtS: 52
GCID: GC05P068746

MARVEL Domain Containing 2

(Previous names: MARVEL (membrane-associating) domain containing 2, deafness,...)
(Previous symbols: MRVLDC2, DFNB49)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MARVEL Domain Containing 21 2     TRIC3 5
DFNB491 2 5     Deafness, Autosomal Recessive 491
MRVLDC21 2     Tric2
MARVEL (Membrane-Associating) Domain Containing 21 2     MARVEL Domain-Containing Protein 22
tricellulin1 2     Tricellulin3
MARVD22 5     

External Ids:    HGNC: 264011   Entrez Gene: 1535622   Ensembl: ENSG000001529397   OMIM: 6105725   UniProtKB: Q8N4S93   

Export aliases for MARVELD2 gene to outside databases

Previous GC identifer: GC05P065667


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MARVELD2 Gene:
The protein encoded by this gene is a membrane protein found at the tight junctions between epithelial cells. The
encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are
required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49).
Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for MARVELD2 Gene:
MARVELD2 (MARVEL domain containing 2) is a protein-coding gene. Diseases associated with MARVELD2 include dfnb49 nonsyndromic hearing loss and deafness, and inclusion conjunctivitis. An important paralog of this gene is ELL3.

UniProtKB/Swiss-Prot: MALD2_HUMAN, Q8N4S9
Function: Plays a role in the formation of the epithelial barriers. The separation of the endolymphatic and
perilymphatic spaces of the organ of Corti from one another by epithelial barriers is required for normal hearing

Gene Wiki entry for MARVELD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MARVELD2 gene promoter:
         HFH-1   FOXD1   IRF-7A   ARP-1   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMARVELD2 promoter sequence
   Search Chromatin IP Primers for MARVELD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARVELD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.2   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q13.1

MARVELD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARVELD2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P068746:  view genomic region     (about GC identifiers)

Start:
68,710,939 bp from pter      End:
68,740,157 bp from pter
Size:
29,219 bases      Orientation:
plus strand

1 alternative location:
Chr5+,NW_003315917.2 198,535-225,032     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MALD2_HUMAN, Q8N4S9 (See protein sequence)
Recommended Name: MARVEL domain-containing protein 2  
Size: 558 amino acids; 64168 Da
Secondary accessions: A1BQX0 A1BQX1 A8KA97 Q96NM9
Alternative splicing: 3 isoforms:  Q8N4S9-1   Q8N4S9-2   Q8N4S9-3   

Explore the universe of human proteins at neXtProt for MARVELD2: NX_Q8N4S9

Explore proteomics data for MARVELD2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys87, Lys175
  • Modification sites at PhosphoSitePlus

  • See MARVELD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001033692.2  NP_001231663.1  

    ENSEMBL proteins: 
     ENSP00000323264   ENSP00000396244   ENSP00000421902   ENSP00000423490   ENSP00000414776  
     ENSP00000398922  

    MARVELD2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR008253 Marvel
     IPR010844 Occludin_RNApol2_elong_fac_ELL

    Graphical View of Domain Structure for InterPro Entry Q8N4S9

    ProtoNet protein and cluster: Q8N4S9

    2 Blocks protein domains:
    IPB008253 Marvel
    IPB010844 Occludin and RNA polymerase II elongation factor ELL


    UniProtKB/Swiss-Prot: MALD2_HUMAN, Q8N4S9
    Similarity: Contains 1 MARVEL domain


    MARVELD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MALD2_HUMAN, Q8N4S9
    Function: Plays a role in the formation of the epithelial barriers. The separation of the endolymphatic and
    perilymphatic spaces of the organ of Corti from one another by epithelial barriers is required for normal hearing

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    MARVELD2 for ontologies           About GeneDecksing


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 1 allele(MGI details for Marveld2):
     cardiovascular system  craniofacial  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     hearing/vestibular/ear  hematopoietic system  immune system  liver/biliary system  muscle 
     nervous system  renal/urinary system  respiratory system  taste/olfaction 

    MARVELD2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MARVELD2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARVELD2
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    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate MARVELD2:
    hsa-miR-140-3p hsa-miR-3671 hsa-miR-34b* hsa-miR-607 hsa-miR-103a-2* hsa-miR-3714 hsa-miR-449c
    SwitchGear 3'UTR luciferase reporter plasmidMARVELD2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MARVELD2

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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MALD2_HUMAN, Q8N4S9: Cell membrane; Multi-pass membrane protein. Cell junction, tight junction (By similarity).
    Note=Found at tricellular contacts (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus3
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane ----
    GO:0005923tight junction IDA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    MARVELD2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MARVELD2
    Interactions:

        GeneGlobe Interaction Network for MARVELD2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for MARVELD2 (ENSP000003232644) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    ELF3ENSP000003526734STRING: ENSP00000352673
    ETV6ENSP000002664274STRING: ENSP00000266427
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007605sensory perception of sound IMP17186462
    GO:0045216cell-cell junction organization IMP--
    GO:0061028establishment of endothelial barrier IMP--
    GO:0070830tight junction assembly IMP--

    MARVELD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MARVELD2 (MALD2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MARVELD2 gene (3 alternative transcripts): 
    NM_001038603.2  NM_001244734.1  NM_144724.1  

    Unigene Cluster for MARVELD2:

    MARVEL domain containing 2
    Hs.657687  [show with all ESTs]
    Unigene Representative Sequence: AK055094
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000325631(uc003jwq.3 uc010ixf.3) ENST00000454295 ENST00000515844
    ENST00000512803 ENST00000436532 ENST00000413223(uc003jws.1)
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate MARVELD2:
    hsa-miR-140-3p hsa-miR-3671 hsa-miR-34b* hsa-miR-607 hsa-miR-103a-2* hsa-miR-3714 hsa-miR-449c
    SwitchGear 3'UTR luciferase reporter plasmidMARVELD2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MARVELD2
    Predesigned siRNA for gene silencing in human, mouse, rat MARVELD2
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MARVELD2 (NM_001038603)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARVELD2
    Primer
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    OriGene qPCR primer pairs and template standards for MARVELD2
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      QuantiTect SYBR Green Assays in human, mouse, rat MARVELD2
      QuantiFast Probe-based Assays in human, mouse, rat MARVELD2

    Additional mRNA sequence: 

    AB219936.1 AB219937.1 AK055094.1 AK292962.1 BC033689.1 DQ682656.1 DQ682657.1 DQ682658.1 

    7 DOTS entries:

    DT.91756161  DT.109014  DT.406580  DT.120855077  DT.86858008  DT.92050085  DT.91994457 

    Selected AceView cDNA sequences (see all 65):

    AI052428 BQ023768 BE090154 AA704297 AA902629 BM766345 BE549594 BC033689 
    CB069382 AK055094 AA524190 R71698 AI355645 AI288538 AI023974 W38683 
    CB069146 AI283471 BF222447 W44766 NM_144724 BQ787868 BM921318 AI140740 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MARVELD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCAGCTCG
    MARVELD2 Expression
    About this image


    MARVELD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
     
     Hair (Integumentary System)
             Bulge Stem Cells Bulge
     
     Brain (Nervous System)
             Cerebellum
     
     Prostate (Endocrine System)
    MARVELD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MARVELD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657687
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARVELD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MARVELD2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Marveld21 , 5 MARVEL (membrane-associating) domain containing 21, 5 85.18(n)1
    88.38(a)1
      13 (53.23 cM)5
    2185181  NM_001038602.41  NP_001033691.11 
     1005959575 
    chicken
    (Gallus gallus)
    Aves MARVELD21 MARVEL domain containing 2 68.41(n)
    68.55(a)
      427393  XM_424965.4  XP_424965.4 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.68802 Transcribed sequence with weak similarity to protein more 77.94(n)    CF225406.1 
    zebrafish
    (Danio rerio)
    Actinopterygii marveld2a1 MARVEL domain containing 2a 63.85(n)
    62.27(a)
      558720  XM_681976.4  XP_687068.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Su(Tpl)6
    Su(Tpl)
    8(a)
    1 → many
    3L(19882220-19902510)


    ENSEMBL Gene Tree for MARVELD2 (if available)
    TreeFam Gene Tree for MARVELD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MARVELD2 gene
    ELL32  OCEL12  ELL22  ELL2  
    1 SIMAP similar gene for MARVELD2 using alignment to 5 protein entries:     MALD2_HUMAN (see all proteins):
    OCEL1

    MARVELD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MARVELD2 (see all 529)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1182039571,2
    Cpathogenic168648466(+) AAAGCC/TGACAG 4 R * stg11Minor allele frequency- T:0.00EU 1323
    rs107065321,2
    C--65677484(+) AAAAA-/AGAAAT 2 -- int1 trp31Minor allele frequency- A:0.50NA 2
    rs113961931,2
    C--65677806(+) AATAC-/TTTTTT 2 -- int1 trp30--------
    rs1903159461,2
    --65677810(+) CTTTTG/TTTTTT 2 -- int10--------
    rs341036721,2
    C,F,H--65683916(+) TCTTCT/CTTTTT 2 -- int13Minor allele frequency- C:0.01NS NA 466
    rs669845231,2
    C--65688489(+) TGGGA-/ACAC  
            
    ACACA
    2 -- int10--------
    rs25837001,2
    C,A--65688534(+) acacaC/TaTATA 2 -- int11Minor allele frequency- T:0.00WA 2
    rs113158321,2
    C--65691160(+) AAAAA-/AGAAGA 2 -- int1 trp31Minor allele frequency- A:0.50NA 2
    rs1445766201,2
    C--68630779(+) GCGCAC/TCTCGG 2 -- int10--------
    rs2008731271,2
    C--68630897(+) GCCTA-/GCCGGC 2 -- int10--------

    HapMap Linkage Disequilibrium report for MARVELD2 (68710939 - 68740157 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MARVELD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730289CNV Deletion23290073
    esv2435100CNV Deletion19546169
    esv2030621CNV Deletion18987734
    nsv881767CNV Loss21882294
    nsv821643CNV Loss15273396
    nsv881768CNV Loss21882294
    esv9527CNV Loss19470904
    nsv428117CNV Gain+Loss18775914

    Human Gene Mutation Database (HGMD): MARVELD2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MARVELD2
    DNA2.0 Custom Variant and Variant Library Synthesis for MARVELD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610572   
    OMIM disorders: 610153  
    UniProtKB/Swiss-Prot: MALD2_HUMAN, Q8N4S9
  • Deafness, autosomal recessive, 49 (DFNB49) [MIM:610153]: A form of non-syndromic sensorineural hearing
    loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to
    the brain, or the area of the brain that receives sound information. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • Selected diseases for MARVELD2 (see all 26):    
    About MalaCards
    dfnb49 nonsyndromic hearing loss and deafness    inclusion conjunctivitis    lymphogranuloma venereum    deafness, autosomal recessive 49
    ophthalmia neonatorum    hepatocellular fibrolamellar carcinoma    trachoma    salpingitis
    nonsyndromic hearing loss and deafness, autosomal recessive    reactive arthritis    deafness and hereditary hearing loss    nonsyndromic hearing loss and deafness
    conjunctivitis    deafness, autosomal recessive 76    nonsyndromic deafness    urethritis
    sensorineural hearing loss    papilloma    choroiditis    arthritis

    2 diseases from the University of Copenhagen DISEASES database for MARVELD2:
    Nonsyndromic deafness     Hepatocellular fibrolamellar carcinoma

    MARVELD2 for disorders           About GeneDecksing


    Export disorders for MARVELD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MARVELD2 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with MARVELD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tricellulin is a tight-junction protein necessary for hearing. (PubMed id 17186462)1, 2, 3, 9 Riazuddin S.... Friedman T.B. (Am. J. Hum. Genet. 2006)
    2. Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. (PubMed id 16365161)1, 2, 9 Ikenouchi J.... Tsukita S. (J. Cell Biol. 2005)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. (PubMed id 20164257)1, 9 Raleigh D.R....Turner J.R. (Mol. Biol. Cell 2010)
    7. Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability. (PubMed id 19535456)1, 9 Krug S.M....Fromm M. (Mol. Biol. Cell 2009)
    8. Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro. (PubMed id 20033365)1, 9 Ohkuni T....Sawada N. (Med Mol Morphol 2009)
    9. Splice-site mutations in the TRIC gene underlie autosomal recessive nonsyndromic hearing impairment in Pakistani families. (PubMed id 18084694)1, 9 Chishti M.S....Ahmad W. (J. Hum. Genet. 2008)
    10. Differential phosphorylation of occludin and tricellulin by CK2 and CK1. (PubMed id 19538290)1, 9 DAPrfel M.J....Huber O. (Ann. N. Y. Acad. Sci. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 153562 HGNC: 26401 AceView: MARVELD2 Ensembl:ENSG00000152939 euGenes: HUgn153562
    ECgene: MARVELD2 H-InvDB: MARVELD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MARVELD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MARVELD2 gene:
    Search GeneIP for patents involving MARVELD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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