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Aliases for MARVELD1 Gene

Aliases for MARVELD1 Gene

  • MARVEL Domain Containing 1 2 3
  • MARVEL (Membrane-Associating) Domain Containing 1 2 3
  • MRVLDC1 3 4
  • Putative MARVEL Domain-Containing Protein 1 3
  • MARVEL Domain-Containing Protein 1 3
  • BA548K23.8 3
  • MARVD1 3
  • GB14 3

External Ids for MARVELD1 Gene

Previous HGNC Symbols for MARVELD1 Gene

  • MRVLDC1

Previous GeneCards Identifiers for MARVELD1 Gene

  • GC10P099464
  • GC10P093098

Summaries for MARVELD1 Gene

GeneCards Summary for MARVELD1 Gene

MARVELD1 (MARVEL Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MARVELD1 Gene

  • Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARVELD1 Gene

Genomics for MARVELD1 Gene

Regulatory Elements for MARVELD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MARVELD1 Gene

Start:
97,713,173 bp from pter
End:
97,718,152 bp from pter
Size:
4,980 bases
Orientation:
Plus strand

Genomic View for MARVELD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARVELD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARVELD1 Gene

Proteins for MARVELD1 Gene

  • Protein details for MARVELD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSK0-MALD1_HUMAN
    Recommended name:
    MARVEL domain-containing protein 1
    Protein Accession:
    Q9BSK0
    Secondary Accessions:

    Protein attributes for MARVELD1 Gene

    Size:
    173 amino acids
    Molecular mass:
    18914 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Down-regulated in primary multiple tumors derived from ovary, vulva, uterus, cervix, breast, testis, kidney bladder and liver. The reduced expression is owing to DNA methylation and could be reversed by pharmacologic demethylation (PubMed:19364627).

neXtProt entry for MARVELD1 Gene

Proteomics data for MARVELD1 Gene at MOPED

Post-translational modifications for MARVELD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MARVELD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MARVELD1 Gene

Domains for MARVELD1 Gene

Protein Domains for MARVELD1 Gene

Suggested Antigen Peptide Sequences for MARVELD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BSK0

UniProtKB/Swiss-Prot:

MALD1_HUMAN :
  • Q9BSK0
Domain:
  • Contains 1 MARVEL domain.
genes like me logo Genes that share domains with MARVELD1: view

No data available for Gene Families for MARVELD1 Gene

Function for MARVELD1 Gene

Molecular function for MARVELD1 Gene

UniProtKB/Swiss-Prot Function: Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration.

Phenotypes for MARVELD1 Gene

GenomeRNAi human phenotypes for MARVELD1:
genes like me logo Genes that share phenotypes with MARVELD1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MARVELD1 Gene

Localization for MARVELD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARVELD1 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton. Nucleus. Note=Observed in the nucleus and at the perinuclear region during interphase, but localizes at the mitotic spindle and midbody at metaphase. A significant fraction of MARVELD1 translocates to the plasma membrane during anaphase or upon microtubule depolymerization (By similarity). {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for MARVELD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with MARVELD1: view

No data available for Subcellular locations from COMPARTMENTS for MARVELD1 Gene

Pathways for MARVELD1 Gene

SuperPathways for MARVELD1 Gene

No Data Available

Interacting Proteins for MARVELD1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000441365%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000441365 for MARVELD1 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for MARVELD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with MARVELD1: view

No data available for Pathways by source for MARVELD1 Gene

Transcripts for MARVELD1 Gene

mRNA/cDNA for MARVELD1 Gene

Unigene Clusters for MARVELD1 Gene

MARVEL domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MARVELD1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARVELD1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2: -
SP3:

Relevant External Links for MARVELD1 Gene

GeneLoc Exon Structure for
MARVELD1
ECgene alternative splicing isoforms for
MARVELD1

Expression for MARVELD1 Gene

mRNA expression in normal human tissues for MARVELD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MARVELD1 Gene

SOURCE GeneReport for Unigene cluster for MARVELD1 Gene Hs.744073

mRNA Expression by UniProt/SwissProt for MARVELD1 Gene

Q9BSK0-MALD1_HUMAN
Tissue specificity: Widely expressed in normal tissues. Down-regulated in multiple primary tumors.
genes like me logo Genes that share expressions with MARVELD1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MARVELD1 Gene

Orthologs for MARVELD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARVELD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARVELD1 35
  • 99.61 (n)
  • 100 (a)
MARVELD1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MARVELD1 35
  • 89.21 (n)
  • 86.71 (a)
MARVELD1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MARVELD1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Marveld1 35
  • 90.89 (n)
  • 88.95 (a)
Marveld1 16
Marveld1 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MARVELD1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MARVELD1 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves MARVELD1 35
  • 66.41 (n)
  • 55.73 (a)
lizard
(Anolis carolinensis)
Reptilia MARVELD1 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia marveld1 35
  • 56.99 (n)
  • 49.03 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5523 35
zebrafish
(Danio rerio)
Actinopterygii marveld1 35
  • 60.59 (n)
  • 49.32 (a)
marveld1 36
  • 46 (a)
OneToOne
Species with no ortholog for MARVELD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARVELD1 Gene

ENSEMBL:
Gene Tree for MARVELD1 (if available)
TreeFam:
Gene Tree for MARVELD1 (if available)

Paralogs for MARVELD1 Gene

No data available for Paralogs for MARVELD1 Gene

Variants for MARVELD1 Gene

Relevant External Links for MARVELD1 Gene

HapMap Linkage Disequilibrium report
MARVELD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for MARVELD1 Gene

Disorders for MARVELD1 Gene

No disorders were found for MARVELD1 Gene.

No data available for UniProtKB/Swiss-Prot for MARVELD1 Gene

Publications for MARVELD1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Identification and characterization of MARVELD1, a novel nuclear protein that is down-regulated in multiple cancers and silenced by DNA methylation. (PMID: 19364627) Wang S. … Wu H. (Cancer Lett. 2009) 3 4
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for MARVELD1 Gene

Sources for MARVELD1 Gene

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