MARS2 Gene
protein-coding GIFtS: 55
GCID: GC02P198570
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methionyl-tRNA synthetase 2, mitochondrial
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Aliases
for MARS2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Methionyl-TRNA Synthetase 2, Mitochondrial1 2 | | Methionine-TRNA Ligase2 | | MtMetRS3 | | Methionine-TRNA Synthetase 2 (Mitochondrial)2 | | Mitochondrial Methionyl-TRNA Synthetase2 3 | | Methionine-TRNA Synthetase 2, Mitochondrial2 | | EC 6.1.1.103 8 | | Methionyl-TRNA Synthetase, Mitochondrial2 | | MetRS2 | | Mitochondrial Methionine--TRNA Ligase2 | | Methionine TRNA Ligase 2, Mitochondrial2 | | MtMetRS3 | | Methionine--TRNA Ligase 22 | | Methionyl-TRNA Synthetase 23 | | Methionine--TRNA Ligase, Mitochondrial2 | | EC 6.1.18 |
Export aliases for MARS2 gene to outside databasesPrevious GC identifers: GC02P198396 GC02P198278 GC02P190422 |
Summaries
for MARS2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for MARS2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MARS2 gene promoter:
USF1 NRSF form 1 MIF-1 NRSF form 2 C/EBPalpha AREB6 SRY NRF-2 USF-1 c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for MARS2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARS2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q33.1 Ensembl cytogenetic band: 2q33.1 HGNC cytogenetic band: 2q33.1MARS2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P198570: view genomic region
(about GC identifiers)
Start:
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198,570,087 bp from pter |
End:
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198,573,114 bp from pter |
Size:
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3,028 bases |
Orientation:
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plus strand |
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Proteins
for MARS2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SYMM_HUMAN, Q96GW9 (See
protein sequence)Recommended Name: Methionine--tRNA ligase, mitochondrial precursor Size: 593 amino acids; 66591 Da
Subcellular location: Mitochondrion matrix (Probable)
Sequence caution: Sequence=AAH09115.1; Type=Erroneous initiation; Sequence=AAH40934.1; Type=Erroneous initiation;
Secondary accessions: A0AVC3 Q76E79 Q8IW62 Q8N7N4Explore the universe of human proteins at neXtProt for MARS2: NX_Q96GW9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96GW9
4/9 DME Specific Peptides for MARS2 (Q96GW9) (see all 9)
MARS2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612404.1
ENSEMBL proteins: ENSP00000282276 Reactome Protein details: Q96GW9
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
-- | -- | | GO:0005759 | mitochondrial matrix |
TAS | -- |
MARS2 for ontologies About GeneDecksing
MARS2 Antibody Products:
Assay Products for MARS2: |
Protein
Domains /
Families
for MARS2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MARS2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96GW9ProtoNet protein and cluster: Q96GW9 2 Blocks protein families: IPB002300 Aminoacyl-tRNA synthetase IPB002304 Methionyl-tRNA synthetase signature
UniProtKB/Swiss-Prot: SYMM_HUMAN, Q96GW9Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family |
Function
for MARS2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SYMM_HUMAN, Q96GW9Catalytic activity: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)Biophysicochemical properties: Kinetic parameters: KM=18 uM for Met; KM=85 uM for ATP; KM=2.1 uM for tRNA-Met; pHdependence: Optimum pH is 7.8-8.2;Enzyme Numbers (IUBMB): EC 6.1.1.101 2 EC 6.1.12
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MARS2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MARS2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for MARS2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARS2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARS2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
MARS2 for ontologies About GeneDecksing
|
Pathways & Interactions
for MARS2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | tRNA Aminoacylation | | | 2 | Selenocompound metabolism | | | 3 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for MARS2
2 
Kegg Pathways (Kegg details for MARS2):
MARS2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MARS2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
5/38 Interacting proteins for MARS2 (Q96GW93 ENSP000002822764) via UniProtKB, MINT, STRING, and/or I2D (see all 38)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
MARS2 for ontologies About GeneDecksing
|
Drugs & Compounds
for MARS2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MARS2
5 HMDB Compounds for MARS2 About this table
1 DrugBank Compound for MARS2 About this table
Search CenterWatch for drugs/clinical trials and news about MARS2 / SYMM
|
Transcripts
for MARS2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MARS2 gene: NM_138395.3 Unigene Cluster for MARS2: Methionyl-tRNA synthetase 2, mitochondrial Hs.744330 [show with all ESTs]Unigene Representative Sequence: NM_1383951 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000282276(uc002uuq.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MARS2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MARS2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MARS2 (NM_138395) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MARS2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARS2 |
Additional cDNA sequence: AB107013.1 AK098121.1 AK301252.1 BC009115.1 BC026361.1 BC040934.2 BC126294.1 1 DOTS entry: DT.40199005 24/38 AceView cDNA sequences (see all 38): BU187587 BM052675 AA665965 BC009115 AV648559 NM_138395 BF109601 AK098121 BI261299 BM052935 AW294266 AB107013 BM978246 CK903898 BE542381 BI092912 BF526996 BG285684 BC040934 BM475242 AA045513 BF346273 BC026361 BP364784
GeneLoc Exon Structure
|
Expression
for MARS2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MARS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGGTTTCC
About this image
See MARS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MARS2
SOURCE GeneReport for Unigene cluster: Hs.744330
SABiosciences Custom PCR Arrays for MARS2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MARS2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MARS2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARS2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARS2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARS2 |
Orthologs
for MARS2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MARS2 gene from 10/39 species (see all 39) About this table
ENSEMBL Gene Tree for MARS2 (if available)
TreeFam Gene Tree for MARS2 (if available) |
Paralogs
for MARS2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MARS2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MARS2 (198570087 - 198573114 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MARS2: --
Human Gene Mutation Database (HGMD): MARS2
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MARS2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MARS2 for disorders About GeneDecksing
OMIM gene information: 609728
OMIM disorders: --
7  diseases for MARS2: About MalaCardsankylosis leigh disease cholelithiasis pneumonia
tuberculosis malaria mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: MARS2 (1 document)
Export disorders for MARS2 gene to outside databases
|
Publications
for MARS2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MARS2 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with MARS2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of the human mitochondrial methionyl-tRNA synthetase. (PubMed id 15274629)1, 2, 3, 7, 9 Spencer A.C.... Spremulli L.L. (2004)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Mutations in the mitochondrial methionyl-tRNA syntheta se cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) i n humans. (PubMed id 22448145)1 Bayat V....Bellen H.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
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External Searches for MARS2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MARS2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MARS2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MARS2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MARS2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MARS2 gene:
Search GeneIP for patents involving MARS2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MARS2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MARS2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MARS2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MARS2 | | | OriGene Protein Over-expression Lysate for MARS2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MARS2 | | OriGene 3'-UTR Clone for MARS2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MARS2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MARS2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MARS2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MARS2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MARS2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARS2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARS2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARS2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARS2 |
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 | | | MARS2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARS2 |
|  |  |  | | | | ThermoFisher Antibodies for MARS2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARS2 |
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