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MARS2 Gene

protein-coding   GIFtS: 54
GCID: GC02P198570

Methionyl-TRNA Synthetase 2, Mitochondrial

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Methionyl-TRNA Synthetase 2, Mitochondrial1 2     Methionine-TRNA Ligase2
Mitochondrial Methionyl-TRNA Synthetase2 3     Methionine-TRNA Synthetase 2 (Mitochondrial)2
EC 6.1.1.103 8     Methionine-TRNA Synthetase 2, Mitochondrial2
SPAX32 5     Methionyl-TRNA Synthetase, Mitochondrial2
Methionine TRNA Ligase 21     Mitochondrial Methionine--TRNA Ligase2
mitochondrial1     mtMetRS2
MetRS2     MtMetRS3
Methionine TRNA Ligase 2, Mitochondrial2     Methionyl-TRNA Synthetase 23
Methionine--TRNA Ligase 22     EC 6.1.18
Methionine--TRNA Ligase, Mitochondrial2     

External Ids:    HGNC: 251331   Entrez Gene: 929352   Ensembl: ENSG000002476267   OMIM: 6097285   UniProtKB: Q96GW93   

Export aliases for MARS2 gene to outside databases

Previous GC identifers: GC02P198396 GC02P198278 GC02P190422


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MARS2 Gene:
MARS2 (methionyl-tRNA synthetase 2, mitochondrial) is a protein-coding gene. Diseases associated with MARS2 include autosomal recessive spastic ataxia with leukoencephalopathy, and ankylosis. GO annotations related to this gene include methionine-tRNA ligase activity.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MARS2 gene promoter:
         USF1   NRSF form 1   MIF-1   NRSF form 2   C/EBPalpha   AREB6   SRY   NRF-2   USF-1   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMARS2 promoter sequence
   Search Chromatin IP Primers for MARS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.1   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33.1

MARS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARS2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P198570:  view genomic region     (about GC identifiers)

Start:
198,570,028 bp from pter      End:
198,573,114 bp from pter
Size:
3,087 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYMM_HUMAN, Q96GW9 (See protein sequence)
Recommended Name: Methionine--tRNA ligase, mitochondrial precursor  
Size: 593 amino acids; 66591 Da
Sequence caution: Sequence=AAH09115.1; Type=Erroneous initiation; Sequence=AAH40934.1; Type=Erroneous initiation;
Secondary accessions: A0AVC3 Q76E79 Q8IW62 Q8N7N4

Explore the universe of human proteins at neXtProt for MARS2: NX_Q96GW9

Explore proteomics data for MARS2 at MOPED

Selected DME Specific Peptides for MARS2 (Q96GW9) (see all 9)
 MSKSLGN  GQKMSKS  TGTDEHG  HIIGKDI 


See MARS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_612404.1  
ENSEMBL proteins: 
 ENSP00000282276  
Reactome Protein details: Q96GW9

MARS2 Human Recombinant Protein Products:

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ThermoFisher Antibodies for MARS2
LSBio Antibodies in human, mouse, rat for MARS2

MARS2 Assay Products:

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Cloud-Clone Corp. ELISAs for MARS2
Cloud-Clone Corp. CLIAs for MARS2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
aaRS1: Aminoacyl tRNA synthetases / Class I

4 InterPro protein domains:
 IPR015413 Methionyl/Leucyl_tRNA_Synth
 IPR009080 tRNAsynth_1a_anticodon-bd
 IPR014729 Rossmann-like_a/b/a_fold
 IPR014758 Met-tRNA_synth

Graphical View of Domain Structure for InterPro Entry Q96GW9

ProtoNet protein and cluster: Q96GW9

2 Blocks protein domains:
IPB002300 Aminoacyl-tRNA synthetase
IPB002304 Methionyl-tRNA synthetase signature


UniProtKB/Swiss-Prot: SYMM_HUMAN, Q96GW9
Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family


MARS2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: SYMM_HUMAN, Q96GW9
Catalytic activity: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
Biophysicochemical properties: Kinetic parameters: KM=18 uM for Met; KM=85 uM for ATP; KM=2.1 uM for tRNA-Met; pH
dependence: Optimum pH is 7.8-8.2;

     Enzyme Numbers (IUBMB): EC 6.1.1.101 2 EC 6.1.12

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000166nucleotide binding ----
GO:0004812aminoacyl-tRNA ligase activity ----
GO:0004825methionine-tRNA ligase activity IDA15274629
GO:0005524ATP binding IEA--
     
MARS2 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MARS2
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MARS2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARS2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARS2

miRNA
Products:
    
miRTarBase miRNAs that target MARS2:
hsa-mir-149-5p (MIRT045487), hsa-let-7b-5p (MIRT001618)

Block miRNA regulation of human, mouse, rat MARS2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate MARS2 (see all 26):
hsa-miR-140-5p hsa-miR-495 hsa-miR-199b-3p hsa-miR-1197 hsa-let-7d hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-3129-5p
SwitchGear 3'UTR luciferase reporter plasmidMARS2 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for MARS2
Predesigned siRNA for gene silencing in human, mouse, rat MARS2

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for MARS2

Clone
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OriGene clones in human, mouse for MARS2 (see all 6)
OriGene ORF clones in mouse, rat for MARS2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: MARS2 (NM_138395)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARS2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARS2

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for MARS2
Browse ESI BIO Cell Lines and PureStem Progenitors for MARS2 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARS2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
SYMM_HUMAN, Q96GW9: Mitochondrion matrix (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
cytosol1
endoplasmic reticulum1
peroxisome1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm ----
GO:0005739mitochondrion ----
GO:0005759mitochondrial matrix TAS--

MARS2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MARS2 About    
See pathways by source

SuperPathContained pathways About
1tRNA Aminoacylation
tRNA Aminoacylation0.57
Mitochondrial tRNA aminoacylation0.50
Aminoacyl-tRNA biosynthesis0.52
2Gene Expression
Gene Expression0.40
3Selenocompound metabolism
Selenocompound metabolism

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for MARS2
    Mitochondrial tRNA aminoacylation


2 Kegg Pathways  (Kegg details for MARS2):
    Selenocompound metabolism
Aminoacyl-tRNA biosynthesis


MARS2 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MARS2
Interactions:

    Search GeneGlobe Interaction Network for MARS2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for MARS2 (Q96GW93 ENSP000002822764) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
InteractantInteraction Details
GeneCardExternal ID(s)
EIF2S3P410913, ENSP000002530394I2D: score=1 STRING: ENSP00000253039
MTIF2P461993, ENSP000002636294I2D: score=1 STRING: ENSP00000263629
PUS3Q9BZE23, ENSP000002274744I2D: score=1 STRING: ENSP00000227474
ELAC2Q9BQ523, ENSP000003374454I2D: score=1 STRING: ENSP00000337445
NARSO437763, ENSP000002568544I2D: score=1 STRING: ENSP00000256854
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006418tRNA aminoacylation for protein translation TAS--
GO:0006431methionyl-tRNA aminoacylation IDA15274629
GO:0010467gene expression TAS--

MARS2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MARS2 (SYMM)

5 HMDB Compounds for MARS2    About this table
CompoundSynonyms CAS #PubMed Ids
Adenosine monophosphate5'-AMP (see all 28)61-19-8--
Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
Selenomethionine(+-)-Selenomethionine (see all 26)3211-76-5--

1 DrugBank Compound for MARS2    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
L-Methionine(S)-2-amino-4-(methylthio)butanoic acid (see all 6)63-68-3enzymesubstrate17139284 17016423 15274629



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MARS2 gene: 
NM_138395.3  

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000282276(uc002uuq.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat MARS2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate MARS2 (see all 26):
hsa-miR-140-5p hsa-miR-495 hsa-miR-199b-3p hsa-miR-1197 hsa-let-7d hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-3129-5p
SwitchGear 3'UTR luciferase reporter plasmidMARS2 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for MARS2
Predesigned siRNA for gene silencing in human, mouse, rat MARS2
Clone
Products:
     
OriGene clones in human, mouse for MARS2 (see all 6)
OriGene ORF clones in mouse, rat for MARS2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: MARS2 (NM_138395)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARS2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARS2
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for MARS2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARS2
  QuantiTect SYBR Green Assays in human, mouse, rat MARS2
  QuantiFast Probe-based Assays in human, mouse, rat MARS2

Selected AceView cDNA sequences (see all 38):

AA665965 AK098121 AV648559 BF109601 BM052675 NM_138395 BU187587 BC009115 
BC026361 BG034002 BI092912 AW294266 CK903898 BX096776 BM978246 BP364784 
BF346273 CD695860 AA045513 BC040934 BM052935 BM475242 AB107013 BF526996 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MARS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTGGGTTTCC
MARS2 Expression
About this image


MARS2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Neurons
         GABAergic Amacrine Cells Inner Nuclear Layer
 
 Eye (Sensory Organs)
         GABAergic Amacrine Cells Inner Nuclear Layer
MARS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MARS2 Protein Expression
    Custom PCR Arrays for MARS2
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for MARS2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARS2
QuantiTect SYBR Green Assays in human, mouse, rat MARS2
QuantiFast Probe-based Assays in human, mouse, rat MARS2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARS2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for MARS2 gene from Selected species (see all 24)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mars21 , 5 methionine-tRNA synthetase 2 (mitochondrial)1, 5 83.56(n)1
86.86(a)1
  1 (28.08 cM)5
2126791  NM_175439.31  NP_780648.11 
 552371775 
chicken
(Gallus gallus)
Aves MARS21 methionyl-tRNA synthetase 2, mitochondrial 64.2(n)
65.13(a)
  428689  XM_426247.4  XP_426247.3 
lizard
(Anolis carolinensis)
Reptilia MARS26
methionyl-tRNA synthetase 2, mitochondrial
65(a)
1 ↔ 1
GL343451.1(340986-346993)
African clawed frog
(Xenopus laevis)
Amphibia MGC688502 hypothetical protein MGC68850 75.07(n)    BC055977.1 
zebrafish
(Danio rerio)
Actinopterygii LOC5665651 methionine--tRNA ligase, mitochondrial-like 59.17(n)
60.8(a)
  566565  XM_689843.6  XP_694935.2 
fruit fly
(Drosophila melanogaster)
Insecta Aats-met1 Methionyl-tRNA synthetase 54.25(n)
48.23(a)
  41733  NM_142091.5  NP_650348.1 
worm
(Caenorhabditis elegans)
Secernentea CELE_Y105E8A.201 CELE_Y105E8A.20 49.8(n)
44.73(a)
  173312  NM_001136325.2  NP_001129797.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSM1(YGR171C)4
MSM11
Mitochondrial methionyl-tRNA synthetase (MetRS), functions more4
MSM11
46.27(n)1
41.7(a)1
  7(842551-840824)4
8530811, 4  NP_011687.11, 4 
thale cress
(Arabidopsis thaliana)
eudicotyledons OVA11 OVA1 46.4(n)
39.19(a)
  824706  NM_115398.2  NP_191100.1 
rice
(Oryza sativa)
Liliopsida Os03g02096001 Os03g0209600 46.85(n)
37.79(a)
  4332018  NM_001055871.1  NP_001049336.1 


ENSEMBL Gene Tree for MARS2 (if available)
TreeFam Gene Tree for MARS2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MARS2 (see all 149)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1840570471,2
--198568049(+) ATGAGG/TTTTTT 1 -- us2k10--------
rs116876981,2
C,F,H--198568076(+) aaattC/Tcttat 1 -- us2k116Minor allele frequency- T:0.22NS EA NA WA 2334
rs1893525041,2
--198568167(+) TTGATA/GGTTTA 1 -- us2k10--------
rs1428426451,2
--198568183(+) TGGTGC/TGGAAA 1 -- us2k10--------
rs1115350551,2
C,F--198568294(+) TTTCCC/TAGGTT 1 -- us2k13Minor allele frequency- T:0.07CSA WA 120
rs1157808271,2
F--198568492(+) AGATGG/ATTGTA 1 -- us2k11Minor allele frequency- A:0.01WA 118
rs1478450161,2
--198568577(+) ACAGAA/TTTCGA 1 -- us2k10--------
rs1398054081,2
--198568580(+) GAATTC/TGATTG 1 -- us2k10--------
rs1808006211,2
--198568884(+) AAAATG/TCAGGA 1 -- us2k10--------
rs48504371,2
C,F,A,H--198569051(+) CAGTAG/TGTGGG 1 -- us2k124Minor allele frequency- T:0.32NS EA NA WA CSA 2352

HapMap Linkage Disequilibrium report for MARS2 (198570028 - 198573114 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for MARS2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv821871CNV Gain20364138

Human Gene Mutation Database (HGMD): MARS2
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing MARS2
DNA2.0 Custom Variant and Variant Library Synthesis for MARS2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609728   
OMIM disorders: 611390  
8 diseases for MARS2:    
About MalaCards
autosomal recessive spastic ataxia with leukoencephalopathy    ankylosis    cholelithiasis    ataxia
spasticity    pneumonia    tuberculosis    malaria


MARS2 for disorders           About GeneDecksing

Genetic Association Database (GAD): MARS2
Human Genome Epidemiology (HuGE) Navigator: MARS2 (1 document)

Export disorders for MARS2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MARS2 gene, integrated from 10 sources (see all 16):
(articles sorted by number of sources associating them with MARS2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of the human mitochondrial methionyl-tRNA synthetase. (PubMed id 15274629)1, 2, 3, 7, 9 Spencer A.C.... Spremulli L.L. (Biochemistry 2004)
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  7. Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans. (PubMed id 22448145)1 Bayat V....Bellen H.J. (PLoS Biol. 2012)
  8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
  9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  10. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 92935 HGNC: 25133 AceView: MetRS Ensembl:ENSG00000247626 euGenes: HUgn92935
ECgene: MARS2 Kegg: 92935 H-InvDB: MARS2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MARS2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MARS2 gene:
Search GeneIP for patents involving MARS2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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