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Aliases for MARS2 Gene

Aliases for MARS2 Gene

  • Methionyl-TRNA Synthetase 2, Mitochondrial 2 3
  • EC 4 63
  • MtMetRS 3 4
  • Methionine-TRNA Synthetase 2, Mitochondrial 3
  • Methionine TRNA Ligase 2, Mitochondrial 3
  • Mitochondrial Methionyl-TRNA Synthetase 4
  • Methionine--TRNA Ligase, Mitochondrial 3
  • Methionyl-TRNA Synthetase 2 4
  • Methionine--TRNA Ligase 2 3
  • Methionine TRNA Ligase 2 2
  • Mitochondrial 2
  • EC 6.1.1 63
  • METRS 3
  • SPAX3 6

External Ids for MARS2 Gene

Previous GeneCards Identifiers for MARS2 Gene

  • GC02P198396
  • GC02P198278
  • GC02P198570
  • GC02P190422

Summaries for MARS2 Gene

Entrez Gene Summary for MARS2 Gene

  • This gene produces a mitochondrial methionyl-tRNA synthetase protein that is encoded by the nuclear genome and imported to the mitochondrion. This protein likely functions as a monomer and is predicted to localize to the mitochondrial matrix. Mutations in this gene are associated with the autosomal recessive neurodegenerative disease spastic ataxia-3 (SPAX3). [provided by RefSeq, Apr 2014]

GeneCards Summary for MARS2 Gene

MARS2 (Methionyl-TRNA Synthetase 2, Mitochondrial) is a Protein Coding gene. Diseases associated with MARS2 include spastic ataxia 3, autosomal recessive. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include methionine-tRNA ligase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARS2 Gene

Genomics for MARS2 Gene

Regulatory Elements for MARS2 Gene

Genomic Location for MARS2 Gene

197,705,304 bp from pter
197,708,390 bp from pter
3,087 bases
Plus strand

Genomic View for MARS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARS2 Gene

Proteins for MARS2 Gene

  • Protein details for MARS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methionine--tRNA ligase, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A0AVC3
    • Q76E79
    • Q8IW62
    • Q8N7N4

    Protein attributes for MARS2 Gene

    593 amino acids
    Molecular mass:
    66591 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH09115.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH40934.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for MARS2 Gene

Proteomics data for MARS2 Gene at MOPED

Post-translational modifications for MARS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MARS2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MARS2

Domains for MARS2 Gene

Gene Families for MARS2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class-I aminoacyl-tRNA synthetase family.
  • Belongs to the class-I aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with MARS2: view

Function for MARS2 Gene

Molecular function for MARS2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=18 uM for Met {ECO:0000269 PubMed:15274629}; KM=85 uM for ATP {ECO:0000269 PubMed:15274629}; KM=2.1 uM for tRNA-Met {ECO:0000269 PubMed:15274629}; pH dependence: Optimum pH is 7.8-8.2. {ECO:0000269 PubMed:15274629};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).

Enzyme Numbers (IUBMB) for MARS2 Gene

Gene Ontology (GO) - Molecular Function for MARS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0004812 aminoacyl-tRNA ligase activity --
GO:0004825 methionine-tRNA ligase activity IDA 15274629
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MARS2: view

Animal Model Products

miRNA for MARS2 Gene

miRTarBase miRNAs that target MARS2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MARS2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for MARS2 Gene

Localization for MARS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARS2 Gene

Mitochondrion matrix.

Subcellular locations from

Jensen Localization Image for MARS2 Gene COMPARTMENTS Subcellular localization image for MARS2 gene
Compartment Confidence
mitochondrion 5
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MARS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix TAS --
GO:0005829 NOT cytosol IBA --
genes like me logo Genes that share ontologies with MARS2: view

Pathways for MARS2 Gene

genes like me logo Genes that share pathways with MARS2: view

Pathways by source for MARS2 Gene

Gene Ontology (GO) - Biological Process for MARS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006431 methionyl-tRNA aminoacylation IDA 15274629
GO:0008219 cell death --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with MARS2: view

Drugs for MARS2 Gene

(1) Drugbank Compounds for MARS2 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • (2S)-2-amino-4-(Methylsulfanyl)butanoic acid
63-68-3 6137 Enzyme substrate approved, nutraceutical

(6) HMDB Compounds for MARS2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-Adenosine monophosphate
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • (2S)-2-amino-4-(methylsulfanyl)butanoate
Phosphoric acid
  • Acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion
genes like me logo Genes that share compounds with MARS2: view

Transcripts for MARS2 Gene

mRNA/cDNA for MARS2 Gene

(38) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MARS2 Gene

Methionyl-tRNA synthetase 2, mitochondrial:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MARS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARS2 Gene

No ASD Table

Relevant External Links for MARS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MARS2 Gene

mRNA expression in normal human tissues for MARS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MARS2 Gene

This gene is overexpressed in Adrenal (18.1), Breast (16.6), and Pancreas (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MARS2 Gene

SOURCE GeneReport for Unigene cluster for MARS2 Gene Hs.744330

genes like me logo Genes that share expressions with MARS2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for MARS2 Gene

Orthologs for MARS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MARS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MARS2 35
  • 88.48 (n)
  • 89.88 (a)
MARS2 36
  • 90 (a)
(Canis familiaris)
Mammalia MARS2 35
  • 87.16 (n)
  • 87.74 (a)
MARS2 36
  • 87 (a)
(Mus musculus)
Mammalia Mars2 35
  • 83.56 (n)
  • 86.86 (a)
Mars2 16
Mars2 36
  • 87 (a)
(Pan troglodytes)
Mammalia MARS2 35
  • 99.49 (n)
  • 99.16 (a)
(Rattus norvegicus)
Mammalia LOC100911305 35
  • 84.07 (n)
  • 87.88 (a)
(Monodelphis domestica)
Mammalia MARS2 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia MARS2 36
  • 35 (a)
(Gallus gallus)
Aves MARS2 35
  • 64.2 (n)
  • 65.13 (a)
MARS2 36
  • 63 (a)
(Anolis carolinensis)
Reptilia MARS2 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488527 35
  • 55.94 (n)
  • 54.11 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68850 35
(Danio rerio)
Actinopterygii LOC566565 35
  • 59.17 (n)
  • 60.8 (a)
MARS2 36
  • 56 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3692 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002383 35
  • 52.93 (n)
  • 46.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta Aats-met 35
  • 54.25 (n)
  • 48.23 (a)
Aats-met 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y105E8A.20 35
  • 49.8 (n)
  • 44.73 (a)
Y105E8A.20 36
  • 44 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL133W 35
  • 47.2 (n)
  • 43.06 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F14971g 35
  • 46.64 (n)
  • 43.42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSM1 35
  • 46.27 (n)
  • 41.7 (a)
MSM1 36
  • 36 (a)
MSM1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons OVA1 35
  • 46.4 (n)
  • 39.19 (a)
(Oryza sativa)
Liliopsida Os03g0209600 35
  • 46.85 (n)
  • 37.79 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03759 35
  • 48.45 (n)
  • 39.68 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC27E2.06c 35
  • 45.82 (n)
  • 44.77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for MARS2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARS2 Gene

Gene Tree for MARS2 (if available)
Gene Tree for MARS2 (if available)

Paralogs for MARS2 Gene

No data available for Paralogs for MARS2 Gene

Variants for MARS2 Gene

Sequence variations from dbSNP and Humsavar for MARS2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3832092 -- 197,707,352(+) TCCTA(-/TTC)TTCAT utr-variant-3-prime
rs4850437 -- 197,704,327(+) CAGTA(G/T)GTGGG upstream-variant-2KB
rs7592344 -- 197,707,737(+) TAAGT(C/T)TCCCT utr-variant-3-prime
rs10931791 -- 197,708,888(+) GTTCA(A/C)GTTAA downstream-variant-500B
rs11345147 -- 197,704,495(+) AAATT(-/A)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MARS2 Gene

Variant ID Type Subtype PubMed ID
nsv821871 CNV Gain 20364138

Relevant External Links for MARS2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARS2 Gene

Disorders for MARS2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MARS2 Gene in MalaCards »

(1) Disease for MARS2 Gene

(1) OMIM Diseases for MARS2 Gene (609728)


  • Spastic ataxia 3, autosomal recessive (SPAX3) [MIM:611390]: A neurologic disorder characterized by cerebellar ataxia, ataxic gait, spasticity, and hyperreflexia. Other variable features include dysarthria, dysmetria, mild cognitive impairment, urinary urgency and dystonic positioning. {ECO:0000269 PubMed:22448145}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MARS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MARS2: view

No data available for University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MARS2 Gene

Publications for MARS2 Gene

  1. Characterization of the human mitochondrial methionyl-tRNA synthetase. (PMID: 15274629) Spencer A.C. … Spremulli L.L. (Biochemistry 2004) 2 3 4 23 25 26
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for MARS2 Gene

Sources for MARS2 Gene

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