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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MARS Gene

protein-coding   GIFtS: 69
GCID: GC12P057881

Methionyl-TRNA Synthetase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Methionyl-TRNA Synthetase1 2 3     MRS2
EC 6.1.1.103 8     Cytosolic Methionyl-TRNA Synthetase2
METRS2 5     Methionine TRNA Ligase 1, Cytoplasmic2
MTRNS2 5     Methionine--TRNA Ligase, Cytoplasmic2
cytoplasmic1     MetRS3
Methionine TRNA Ligase 11     

External Ids:    HGNC: 68981   Entrez Gene: 41412   Ensembl: ENSG000001669867   OMIM: 1565605   UniProtKB: P561923   

Export aliases for MARS gene to outside databases

Previous GC identifers: GC12M059209 GC12P058025 GC12P057598 GC12P056168 GC12P056167 GC12P054919


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MARS Gene:
This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role
in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of
the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. (provided by
RefSeq, Jan 2011)

GeneCards Summary for MARS Gene: 
MARS (methionyl-tRNA synthetase) is a protein-coding gene. Diseases associated with MARS include hepatorenal syndrome, and appendicitis, and among its related super-pathways are Cytosolic tRNA aminoacylation and Generic Transcription Pathway. GO annotations related to this gene include methionine-tRNA ligase activity and tRNA binding.

Gene Wiki entry for MARS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MARS gene promoter:
         Spz1   Sox5   Elk-1   NF-1   CUTL1   GATA-1   GATA-2   PPAR-alpha   c-Myb   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMARS promoter sequence
   Search SABiosciences Chromatin IP Primers for MARS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13

MARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARS gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P057881:  view genomic region     (about GC identifiers)

Start:
57,869,228 bp from pter      End:
57,911,352 bp from pter
Size:
42,125 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYMC_HUMAN, P56192 (See protein sequence)
Recommended Name: Methionine--tRNA ligase, cytoplasmic  
Size: 900 amino acids; 101116 Da
Subunit: Component of the multisynthetase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA
synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA
synthetases as well as three auxiliary proteins, p18, p48 and p43
Subcellular location: Cytoplasm (Probable)
3 PDB 3D structures from and Proteopedia for MARS:
2DJV (3D)        4BJV (3D)        4BJW (3D)    
Secondary accessions: Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0

Explore the universe of human proteins at neXtProt for MARS: NX_P56192

Explore proteomics data for MARS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P56192

  • 4/17 DME Specific Peptides for MARS (P56192) (see all 17)
     ALPYVNN  ARGDQCD  CGKLINA  EICDKYH 

    MARS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MARS Protein Expression
    REFSEQ proteins: NP_004981.2  
    ENSEMBL proteins: 
     ENSP00000446168   ENSP00000262027   ENSP00000439307   ENSP00000447145   ENSP00000446729  
     ENSP00000447258   ENSP00000448576   ENSP00000450018   ENSP00000447914   ENSP00000449071  
     ENSP00000449787   ENSP00000448910   ENSP00000447335   ENSP00000448378   ENSP00000314653  
    Reactome Protein details: P56192
    Human Recombinant Protein Products for MARS: 
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    Novus Biologicals MARS Proteins
    Novus Biologicals MARS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MARS 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    MARS for ontologies           About GeneDecksing



    MARS Antibody Products: 
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    Cloud-Clone Corp. ELISAs for MARS 
    Cloud-Clone Corp. CLIAs for MARS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    aaRS1: Aminoacyl tRNA synthetases / Class I

    5/10 InterPro protein domains (see all 10):
     IPR015413 Methionyl/Leucyl_tRNA_Synth
     IPR000738 WHEP-TRS
     IPR023458 Met-tRNA_ligase_1
     IPR009068 S15_NS1_RNA-bd
     IPR001412 aa-tRNA-synth_I_CS

    Graphical View of Domain Structure for InterPro Entry P56192

    ProtoNet protein and cluster: P56192

    2 Blocks protein domains:
    IPB002300 Aminoacyl-tRNA synthetase
    IPB002304 Methionyl-tRNA synthetase signature


    UniProtKB/Swiss-Prot: SYMC_HUMAN, P56192
    Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 WHEP-TRS domain


    MARS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYMC_HUMAN, P56192
    Catalytic activity: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)

         Genatlas biochemistry entry for MARS:
    methionine tRNA synthetase

         Enzyme Number (IUBMB): EC 6.1.1.101 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IEA--
    GO:0000166nucleotide binding ----
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004825methionine-tRNA ligase activity TAS--
    GO:0005524ATP binding IEA--
         
    MARS for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MARS:
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MARS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MARS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARS 

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    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-508-3p hsa-miR-93 hsa-miR-493* hsa-miR-20b
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MARS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Aminoacyl-tRNA biosynthesis0.54
    Cytosolic tRNA aminoacylation0.57
    2Generic Transcription Pathway
    Gene Expression0.47
    3Cysteine and methionine metabolism
    Methionine metabolism0.32
    4Selenocompound metabolism
    Selenocompound metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MARS
        Methionine metabolism


    1 GeneGo (Thomson Reuters) Pathway for MARS
        Methionine metabolism

    3        Reactome Pathways for MARS
        Cytosolic tRNA aminoacylation
    tRNA Aminoacylation
    Gene Expression


    2         Kegg Pathways  (Kegg details for MARS):
        Selenocompound metabolism
    Aminoacyl-tRNA biosynthesis


    MARS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MARS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/136 Interacting proteins for MARS (P561921, 2, 3 ENSP000002620274) via UniProtKB, MINT, STRING, and/or I2D (see all 136)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006431methionyl-tRNA aminoacylation IEA--
    GO:0010467gene expression TAS--

    MARS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MARS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MARS (SYMC)

    6 HMDB Compounds for MARS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Methionine(2S)-2-amino-4-(methylsulfanyl)butanoic acid (see all 54)63-68-3--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Selenomethionine(+-)-Selenomethionine (see all 26)3211-76-5--

    1 DrugBank Compound for MARS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Methionine(S)-2-amino-4-(methylthio)butanoic acid (see all 6)63-68-3enzymesubstrate17327360 16787318 16702349

    10/14 Novoseek inferred chemical compound relationships for MARS gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    homocysteine thiolactone 91.7 4 8425610 (2), 12234471 (1), 10721911 (1)
    methionyl adenylate 87.6 4 10360737 (2), 16155581 (1)
    aminoacyl-trna 85.4 2 12440524 (1), 9548745 (1)
    trna(met) 82.1 2 1408786 (1)
    anticodon 77.9 6 1280807 (2), 16155581 (1), 1408786 (1), 17510965 (1)
    trna 77.6 39 1408786 (3), 11714285 (3), 11118226 (3), 11732605 (2) (see all 13)
    methionine 69.9 25 19837083 (4), 8679580 (2), 10884371 (1), 17327360 (1) (see all 10)
    homocysteine 67.6 22 14656026 (1), 16769724 (1), 10884371 (1), 16106241 (1) (see all 13)
    lysine 51.6 2 14656026 (1), 11686577 (1)
    mgatp 38.2 4 1555604 (3), 9129831 (1)

    Search CenterWatch for drugs/clinical trials and news about MARS / SYMC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MARS gene: 
    NM_004990.3  

    Unigene Cluster for MARS:

    Methionyl-tRNA synthetase
    Hs.632707  [show with all ESTs]
    Unigene Representative Sequence: NM_004990
    18/33 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 33):
    ENST00000549133 ENST00000537638(uc001sof.1 uc010srp.1) ENST00000262027(uc001sog.3)
    ENST00000548674 ENST00000550449 ENST00000546481 ENST00000545888(uc001soh.1)
    ENST00000547062 ENST00000548714 ENST00000551842 ENST00000553162 ENST00000547501
    ENST00000551431 ENST00000549074 ENST00000447721 ENST00000552007 ENST00000551892
    ENST00000548146
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate MARS (see all 11):
    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-508-3p hsa-miR-93 hsa-miR-493* hsa-miR-20b
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    Additional mRNA sequence: 

    AK222767.1 AK290857.1 AK303349.1 BC002384.2 BC006328.2 BC011639.2 BC011849.2 BC015011.1 
    BC065187.1 BT007338.1 D84224.1 X94754.1 Z49216.1 

    24/57 DOTS entries (see all 57):

    DT.100640144  DT.97863484  DT.87078184  DT.100045496  DT.91780655  DT.95079534  DT.100804509  DT.102841106 
    DT.95259612  DT.102841118  DT.100687100  DT.121187536  DT.100687081  DT.121187578  DT.121187400  DT.100739314 
    DT.97810576  DT.100061021  DT.121187401  DT.100687079  DT.95193903  DT.100045484  DT.121187561  DT.121187588 

    24/901 AceView cDNA sequences (see all 901):

    AI244152 AA218816 AW410856 BQ130073 BP345158 BU629165 BU687608 CB158674 
    BM464351 BI226372 BG106572 CA314320 CD368375 BP344587 BM979515 AU132644 
    AU280304 BM783715 BG250590 BX415894 AA188863 CB157345 AA298540 BT007338 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for MARS (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b
    SP1:                                                                                                                                    
    SP2:                                                                                                                                    
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                -                                                                                                   


    ECgene alternative splicing isoforms for MARS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MARS expression in normal human tissues (normalized intensities)      MARS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCACGGTTA
    MARS Expression
    About this image


    MARS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/39 selected tissues (see all 39) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             brain/midbrain   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             heart muscle ; myocytes   
             heart/atrium   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; endothelial cells   

    See MARS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MARS

    SOURCE GeneReport for Unigene cluster: Hs.632707
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MARS gene from 9/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mars1 , 5 methionine-tRNA synthetase1, 5 86.89(n)1
    89.67(a)1
      10 (74.50 cM)5
    2164431  NM_001171582.11  NP_001165053.11 
     1272962215 
    chicken
    (Gallus gallus)
    Aves MARS1 methionyl-tRNA synthetase 67.08(n)
    66.93(a)
      425613  XM_423353.2  XP_423353.2 
    lizard
    (Anolis carolinensis)
    Reptilia MARS6
    methionyl-tRNA synthetase
    68(a)
    1 ↔ 1
    GL343212.1(580052-617518)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC691502 hypothetical protein MGC69150 76.61(n)    BC057757.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mars2 methionine-tRNA synthetase 75.33(n)   338183  BC046899.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG151001 CG15100 54.93(n)
    52.56(a)
      37177  NM_137538.1  NP_611382.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mrs-13
    mars-11
    methionyl-tRNA synthetase3
    Protein MARS-11
    60(a)3
    56.28(n)1
    57.71(a)1
      IV(11632339-11635644)3
    1780891  NM_069795.41  NP_502196.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MES1(YGR264C)4
    MES11
    Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA more4
    Mes1p1
    53.97(n)1
    52.03(a)1
      7(1021853-1019598)4
    8531811, 4  NP_011780.31  NP_011780.14 
    rice
    (Oryza sativa)
    Liliopsida AF040700.12   -- 75.85(n)    AF040700.1 


    ENSEMBL Gene Tree for MARS (if available)
    TreeFam Gene Tree for MARS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/413 SNPs in MARS are shown (see all 413)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0204594
    ----see VAR_0204592 A D mis40--------
    rs1908435211,2
    C--57879811(+) CTAGAC/TAGCCT 1 -- us2k10--------
    rs1833975861,2
    C--57879830(+) AGCTGA/CAAAAC 1 -- us2k10--------
    rs748755701,2
    C,F--57879977(+) AGAAGC/TGTCCC 1 -- us2k11Minor allele frequency- T:0.05NA 120
    rs1181204171,2
    C,F--57879986(+) CCTTTC/ATCAAT 1 -- us2k11Minor allele frequency- A:0.04EA 120
    rs1507686251,2
    --57880003(+) TATGTA/GCTTCC 1 -- us2k10--------
    rs1880527201,2
    --57880046(+) GCCATC/TTTGAA 1 -- us2k10--------
    rs1380124951,2
    --57880085(+) TCTTGA/CTCTAT 1 -- us2k10--------
    rs1997283791,2
    C--57880398(+) GGCGC-/GGTGGCTG 1 -- cds10--------
    rs1495105791,2
    --57880768(+) ACATTC/GTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MARS (57869228 - 57911352 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for MARS:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1408918CNV Insertion17803354
    nsv469411CNV Loss19166990
    nsv899119CNV Loss21882294
    nsv899120CNV Loss21882294
    nsv819781CNV Loss19587683
    nsv899117CNV Loss21882294
    nsv428283CNV Gain18775914
    nsv899118CNV Gain21882294
    dgv513e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 156560    OMIM disorders: --

    14 diseases for MARS:    About MalaCards
    hepatorenal syndrome    appendicitis    clostridium difficile    hepatic encephalopathy
    tuberculosis    cholestasis    vascular disease    atherosclerosis
    liver disease    pneumonia    hepatitis    endotheliitis
    breast cancer    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for MARS:
    Liver disease     Voyeurism

    MARS for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MARS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberculosis 0 3 9607323 (2), 10360737 (1)

    Genetic Association Database (GAD): MARS
    Human Genome Epidemiology (HuGE) Navigator: MARS (23 documents)

    Export disorders for MARS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MARS gene, integrated from 9 sources (see all 121):
    (articles sorted by number of sources associating them with MARS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability. (PubMed id 10448063)1, 3, 9 Ubeda M....Habener J.F. (1999)
    2. Cloning of a human cDNA encoding a protein with high homology to yeast methionyl-tRNA synthetase. (PubMed id 8921912)1, 2, 9 Lage H. and Dietel M. (1996)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Polymorphisms in mitochondrial genes and prostate can cer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function. (PubMed id 11714285)1, 9 Kaminska M....Mirande M. (2001)
    8. Methionyl-tRNA synthetase. (PubMed id 11732605)1, 9 Deniziak M.A. and Barciszewski J. (2001)
    9. Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis. (PubMed id 10791971)1, 9 Ko Y.G....Kim S. (2000)
    10. Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice. (PubMed id 17327360)7, 9 Chwatko G....Jakubowski H. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4141 HGNC: 6898 AceView: MARS Ensembl:ENSG00000166986 euGenes: HUgn4141
    ECgene: MARS Kegg: 4141 H-InvDB: MARS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MARS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MARS gene:
    Search GeneIP for patents involving MARS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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