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MARS Gene

protein-coding   GIFtS: 71
GCID: GC12P057881

Methionyl-TRNA Synthetase

  See MARS-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Methionyl-TRNA Synthetase1 2 3     MRS2
EC 6.1.1.103 8     SPG702
METRS2 5     Cytosolic Methionyl-TRNA Synthetase2
MTRNS2 5     Methionine--TRNA Ligase, Cytoplasmic2
cytoplasmic1     MetRS3
Methionine TRNA Ligase 11     

External Ids:    HGNC: 68981   Entrez Gene: 41412   Ensembl: ENSG000001669867   OMIM: 1565605   UniProtKB: P561923   

Export aliases for MARS gene to outside databases

Previous GC identifers: GC12M059209 GC12P058025 GC12P057598 GC12P056168 GC12P056167 GC12P054919


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MARS Gene:
This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role
in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of
the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. (provided by
RefSeq, Jan 2011)

GeneCards Summary for MARS Gene:
MARS (methionyl-tRNA synthetase) is a protein-coding gene. Diseases associated with MARS include autosomal recessive spastic paraplegia type 70, and voyeurism. GO annotations related to this gene include methionine-tRNA ligase activity and tRNA binding.

Gene Wiki entry for MARS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MARS gene promoter:
         Spz1   Sox5   Elk-1   NF-1   CUTL1   GATA-1   GATA-2   PPAR-alpha   c-Myb   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMARS promoter sequence
   Search Chromatin IP Primers for MARS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13

MARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARS gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P057881:  view genomic region     (about GC identifiers)

Start:
57,869,228 bp from pter      End:
57,911,352 bp from pter
Size:
42,125 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYMC_HUMAN, P56192 (See protein sequence)
Recommended Name: Methionine--tRNA ligase, cytoplasmic  
Size: 900 amino acids; 101116 Da
Subunit: Component of the multisynthetase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA
synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA
synthetases as well as three auxiliary proteins, p18, p48 and p43
1 PDB 3D structure from and Proteopedia for MARS:
2DJV (3D)    
Secondary accessions: Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0

Explore the universe of human proteins at neXtProt for MARS: NX_P56192

Explore proteomics data for MARS at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys191, Lys375, Lys500, Lys663, Lys698, Lys726
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MARS (P56192) (see all 17)
     ALPYVNN  ARGDQCD  CGKLINA  EICDKYH 


    See MARS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004981.2  
    ENSEMBL proteins: 
     ENSP00000446168   ENSP00000262027   ENSP00000439307   ENSP00000447145   ENSP00000446729  
     ENSP00000447258   ENSP00000448576   ENSP00000450018   ENSP00000447914   ENSP00000449071  
     ENSP00000449787   ENSP00000448910   ENSP00000447335   ENSP00000448378   ENSP00000314653  
    Reactome Protein details: P56192

    MARS Human Recombinant Protein Products:

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    Novus Biologicals MARS Proteins
    Novus Biologicals MARS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MARS

     
    Search eBioscience for Proteins for MARS 

    MARS Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    MARS Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MARS
    Cloud-Clone Corp. CLIAs for MARS
    Search eBioscience for ELISAs for MARS 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    aaRS1: Aminoacyl tRNA synthetases / Class I

    Selected InterPro protein domains (see all 9):
     IPR015413 Methionyl/Leucyl_tRNA_Synth
     IPR000738 WHEP-TRS
     IPR023458 Met-tRNA_ligase_1
     IPR009068 S15_NS1_RNA-bd
     IPR001412 aa-tRNA-synth_I_CS

    Graphical View of Domain Structure for InterPro Entry P56192

    ProtoNet protein and cluster: P56192

    2 Blocks protein domains:
    IPB002300 Aminoacyl-tRNA synthetase
    IPB002304 Methionyl-tRNA synthetase signature


    UniProtKB/Swiss-Prot: SYMC_HUMAN, P56192
    Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 WHEP-TRS domain


    Find genes that share domains with MARS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYMC_HUMAN, P56192
    Catalytic activity: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)

         Genatlas biochemistry entry for MARS:
    methionine tRNA synthetase

         Enzyme Number (IUBMB): EC 6.1.1.101 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IEA--
    GO:0000166nucleotide binding ----
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004825methionine-tRNA ligase activity TAS--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with MARS           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MARS:
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MARS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MARS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARS

    miRNA
    Products:
        
    miRTarBase miRNAs that target MARS:
    hsa-mir-222-3p (MIRT046729), hsa-mir-16-5p (MIRT031964), hsa-mir-615-3p (MIRT040324), hsa-mir-193b-3p (MIRT041304), hsa-mir-296-3p (MIRT038386), hsa-mir-339-5p (MIRT042790), hsa-let-7b-5p (MIRT032489), hsa-mir-92a-3p (MIRT049733), hsa-mir-484 (MIRT042166), hsa-mir-10a-5p (MIRT047668), hsa-mir-505-5p (MIRT037977), hsa-mir-185-5p (MIRT045372)

    Block miRNA regulation of human, mouse, rat MARS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MARS (see all 11):
    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-508-3p hsa-miR-93 hsa-miR-493* hsa-miR-20b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MARS
    Predesigned siRNA for gene silencing in human, mouse, rat MARS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MARS

    Clone
    Products:
         
    OriGene clones in human, mouse for MARS (see all 7)
    OriGene ORF clones in mouse, rat for MARS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MARS (NM_004990)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARS
    Addgene plasmids for MARS 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MARS 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYMC_HUMAN, P56192: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    mitochondrion2
    peroxisome2
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with MARS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MARS About    
    See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Aminoacyl-tRNA biosynthesis0.52
    Cytosolic tRNA aminoacylation0.57
    2Gene Expression
    Gene Expression0.40
    3One carbon pool by folate
    Methionine metabolism0.35
    4Selenocompound metabolism
    Selenocompound metabolism


    Find genes that share SuperPaths with MARS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for MARS
        Methionine metabolism

    1 Reactome Pathway for MARS
        Cytosolic tRNA aminoacylation


    2 Kegg Pathways  (Kegg details for MARS):
        Selenocompound metabolism
    Aminoacyl-tRNA biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MARS
    Interactions:

        GeneGlobe Interaction Network for MARS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MARS (P561922, 3 ENSP000002620274) via UniProtKB, MINT, STRING, and/or I2D (see all 176)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006431methionyl-tRNA aminoacylation IEA--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with MARS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MARS (SYMC)

    6 HMDB Compounds for MARS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Methionine(2S)-2-amino-4-(methylsulfanyl)butanoic acid (see all 54)63-68-3--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Selenomethionine(+-)-Selenomethionine (see all 26)3211-76-5--

    1 DrugBank Compound for MARS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Methionine(S)-2-amino-4-(methylthio)butanoic acid (see all 6)63-68-3enzymesubstrate17327360 16787318 16702349

    Selected Novoseek inferred chemical compound relationships for MARS gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    homocysteine thiolactone 91.7 4 8425610 (2), 12234471 (1), 10721911 (1)
    methionyl adenylate 87.6 4 10360737 (2), 16155581 (1)
    aminoacyl-trna 85.4 2 12440524 (1), 9548745 (1)
    trna(met) 82.1 2 1408786 (1)
    anticodon 77.9 6 1280807 (2), 16155581 (1), 1408786 (1), 17510965 (1)
    trna 77.6 39 1408786 (3), 11714285 (3), 11118226 (3), 11732605 (2) (see all 13)
    methionine 69.9 25 19837083 (4), 8679580 (2), 10884371 (1), 17327360 (1) (see all 10)
    homocysteine 67.6 22 14656026 (1), 16769724 (1), 10884371 (1), 16106241 (1) (see all 13)
    lysine 51.6 2 14656026 (1), 11686577 (1)
    mgatp 38.2 4 1555604 (3), 9129831 (1)



    Find genes that share compounds with MARS           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MARS gene: 
    NM_004990.3  

    Unigene Cluster for MARS:

    Methionyl-tRNA synthetase
    Hs.632707  [show with all ESTs]
    Unigene Representative Sequence: NM_004990
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 33):
    ENST00000549133 ENST00000537638(uc001sof.1 uc010srp.1) ENST00000262027(uc001sog.3)
    ENST00000548674 ENST00000550449 ENST00000546481 ENST00000545888(uc001soh.1)
    ENST00000547062 ENST00000548714 ENST00000551842 ENST00000553162 ENST00000547501
    ENST00000551431 ENST00000549074 ENST00000447721 ENST00000552007 ENST00000551892
    ENST00000548146
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MARS (see all 11):
    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-508-3p hsa-miR-93 hsa-miR-493* hsa-miR-20b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MARS
    Clone
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    OriGene clones in human, mouse for MARS (see all 7)
    OriGene ORF clones in mouse, rat for MARS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MARS (NM_004990)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARS
    Addgene plasmids for MARS 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MARS
    OriGene qSTAR qPCR primer pairs in human, mouse for MARS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARS
      QuantiTect SYBR Green Assays in human, mouse, rat MARS
      QuantiFast Probe-based Assays in human, mouse, rat MARS

    Additional mRNA sequence: 

    AK222767.1 AK290857.1 AK303349.1 BC002384.2 BC006328.2 BC011639.2 BC011849.2 BC015011.1 
    BC065187.1 BT007338.1 D84224.1 X94754.1 Z49216.1 

    Selected DOTS entries (see all 57):

    DT.100640144  DT.97863484  DT.87078184  DT.100045496  DT.91780655  DT.95079534  DT.100804509  DT.102841106 
    DT.95259612  DT.102841118  DT.100687100  DT.121187536  DT.100687081  DT.121187578  DT.121187400  DT.100739314 
    DT.97810576  DT.100061021  DT.121187401  DT.100687079  DT.95193903  DT.100045484  DT.121187561  DT.121187588 

    Selected AceView cDNA sequences (see all 901):

    BQ671441 BM783552 T09204 D84224 AA218816 AA126290 BE836749 CA308631 
    CA942576 BM464351 BQ059546 AW410856 BM750258 CB158674 BM458626 NM_004990 
    BM843371 BM459176 BM667798 BU687608 AI809298 BM743756 BQ649820 AA298540 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MARS (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b
    SP1:                                                                                                                                    
    SP2:                                                                                                                                    
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                -                                                                                                   


    ECgene alternative splicing isoforms for MARS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MARS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCACGGTTA
    MARS Expression
    About this image


    MARS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    MARS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MARS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632707
        Custom PCR Arrays for MARS
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MARS gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mars1 , 5 methionine-tRNA synthetase1, 5 86.89(n)1
    89.67(a)1
      10 (74.50 cM)5
    2164431  NM_001171582.11  NP_001165053.11 
     1272962215 
    chicken
    (Gallus gallus)
    Aves MARS1 methionyl-tRNA synthetase 66.89(n)
    66.97(a)
      425613  NM_001257372.1  NP_001244301.1 
    lizard
    (Anolis carolinensis)
    Reptilia MARS6
    methionyl-tRNA synthetase
    68(a)
    1 ↔ 1
    GL343212.1(580052-617518)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC691502 hypothetical protein MGC69150 76.61(n)    BC057757.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mars2 methionine-tRNA synthetase 75.33(n)   338183  BC046899.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG151001 CG15100 54.76(n)
    52.81(a)
      37177  NM_137538.1  NP_611382.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mrs-13 methionyl-tRNA synthetase 60(a)   IV(11632339-11635644)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MES1(YGR264C)4
    MES11
    Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA more4
    MES11
    53.97(n)1
    52.03(a)1
      7(1021853-1019598)4
    8531811, 4  NP_011780.31  NP_011780.14 
    rice
    (Oryza sativa)
    Liliopsida AF040700.12   -- 75.85(n)    AF040700.1 


    ENSEMBL Gene Tree for MARS (if available)
    TreeFam Gene Tree for MARS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MARS (see all 415)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0708734
    Infantile liver failure syndrome 2 (ILFS2)4--see VAR_0708732 I T mis40--------
    VAR_0708724
    Infantile liver failure syndrome 2 (ILFS2)4--see VAR_0708722 F L mis40--------
    rs1908435211,2
    C--57879811(+) CTAGAC/TAGCCT 1 -- us2k10--------
    rs1833975861,2
    C--57879830(+) AGCTGA/CAAAAC 1 -- us2k10--------
    rs748755701,2
    C,F--57879977(+) AGAAGC/TGTCCC 1 -- us2k11Minor allele frequency- T:0.05NA 120
    rs1181204171,2
    C,F--57879986(+) CCTTTC/ATCAAT 1 -- us2k11Minor allele frequency- A:0.04EA 120
    rs1507686251,2
    --57880003(+) TATGTA/GCTTCC 1 -- us2k10--------
    rs1880527201,2
    --57880046(+) GCCATC/TTTGAA 1 -- us2k10--------
    rs1380124951,2
    --57880085(+) TCTTGA/CTCTAT 1 -- us2k10--------
    rs1997283791,2
    C--57880398(+) GGCGC-/GGTGGCTG 1 -- cds10--------

    HapMap Linkage Disequilibrium report for MARS (57869228 - 57911352 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for MARS:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1408918CNV Insertion17803354
    nsv469411CNV Loss19166990
    nsv899119CNV Loss21882294
    nsv899120CNV Loss21882294
    nsv819781CNV Loss19587683
    nsv899117CNV Loss21882294
    nsv428283CNV Gain18775914
    nsv899118CNV Gain21882294
    dgv513e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): MARS
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MARS
    DNA2.0 Custom Variant and Variant Library Synthesis for MARS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 156560   
    OMIM disorders: 615486  
    5 diseases for MARS:    
    About MalaCards
    autosomal recessive spastic paraplegia type 70    voyeurism    infantile liver failure syndrome 2    autosomal dominant charcot-marie-tooth disease type 2 due to mars mutation
    liver failure, infantile, syndromic

    2 diseases from the University of Copenhagen DISEASES database for MARS:
    Liver disease     Voyeurism

    Find genes that share disorders with MARS           About GenesLikeMe

    1 Novoseek inferred disease relationship for MARS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberculosis 0 3 9607323 (2), 10360737 (1)

    Genetic Association Database (GAD): MARS
    Human Genome Epidemiology (HuGE) Navigator: MARS (23 documents)

    Export disorders for MARS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MARS gene, integrated from 10 sources (see all 127):
    (articles sorted by number of sources associating them with MARS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability. (PubMed id 10448063)1, 3, 9 Ubeda M....Habener J.F. (Biochem. Biophys. Res. Commun. 1999)
    2. Cloning of a human cDNA encoding a protein with high homology to yeast methionyl-tRNA synthetase. (PubMed id 8921912)1, 2, 9 Lage H. and Dietel M. (Gene 1996)
    3. Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. (PubMed id 24482476)1, 3 Novarino G....Gleeson J.G. (Science 2014)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function. (PubMed id 11714285)1, 9 Kaminska M....Mirande M. (Biochemistry 2001)
    9. Methionyl-tRNA synthetase. (PubMed id 11732605)1, 9 Deniziak M.A. and Barciszewski J. (Acta Biochim. Pol. 2001)
    10. Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis. (PubMed id 10791971)1, 9 Ko Y.G....Kim S. (J. Cell Biol. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4141 HGNC: 6898 AceView: MARS Ensembl:ENSG00000166986 euGenes: HUgn4141
    ECgene: MARS Kegg: 4141 H-InvDB: MARS

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MARS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MARS gene:
    Search GeneIP for patents involving MARS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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