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Aliases for MARS Gene

Aliases for MARS Gene

  • Methionyl-TRNA Synthetase 2 3 4
  • METRS 3 4 6
  • EC 6.1.1.10 4 64
  • MTRNS 3 6
  • Methionine--TRNA Ligase, Cytoplasmic 3
  • Cytosolic Methionyl-TRNA Synthetase 3
  • Methionine TRNA Ligase 1 2
  • Cytoplasmic 2
  • CMT2U 3
  • ILFS2 3
  • SPG70 3
  • MRS 3

External Ids for MARS Gene

Summaries for MARS Gene

Entrez Gene Summary for MARS Gene

  • This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. [provided by RefSeq, Jan 2011]

GeneCards Summary for MARS Gene

MARS (Methionyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with MARS include infantile liver failure syndrome 2 and voyeurism. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include tRNA binding and methionine-tRNA ligase activity.

Gene Wiki entry for MARS Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARS Gene

Genomics for MARS Gene

Genomic Location for MARS Gene

Start:
57,475,445 bp from pter
End:
57,517,569 bp from pter
Size:
42,125 bases
Orientation:
Plus strand

Genomic View for MARS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARS Gene

Regulatory Elements for MARS Gene

Proteins for MARS Gene

  • Protein details for MARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56192-SYMC_HUMAN
    Recommended name:
    Methionine--tRNA ligase, cytoplasmic
    Protein Accession:
    P56192
    Secondary Accessions:
    • B3KVK7
    • Q14895
    • Q53H14
    • Q96A15
    • Q96BZ0
    • Q9NSE0

    Protein attributes for MARS Gene

    Size:
    900 amino acids
    Molecular mass:
    101116 Da
    Quaternary structure:
    • Component of the multisynthetase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases as well as three auxiliary proteins, p18, p48 and p43

    Three dimensional structures from OCA and Proteopedia for MARS Gene

    Alternative splice isoforms for MARS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARS Gene

Proteomics data for MARS Gene at MOPED

Post-translational modifications for MARS Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys191, Lys375, Lys500, Lys663, Lys698, and Lys726

Domains for MARS Gene

Gene Families for MARS Gene

HGNC:
  • aaRS1 :Aminoacyl tRNA synthetases / Class I

UniProtKB/Swiss-Prot:

SYMC_HUMAN
Domain:
  • Contains 1 GST C-terminal domain.:
    • P56192
  • Contains 1 WHEP-TRS domain.:
    • P56192
Family:
  • Belongs to the class-I aminoacyl-tRNA synthetase family.:
    • P56192
genes like me logo Genes that share domains with MARS: view

Function for MARS Gene

Molecular function for MARS Gene

GENATLAS Biochemistry: methionine tRNA synthetase
UniProtKB/Swiss-Prot CatalyticActivity: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)

Enzyme Numbers (IUBMB) for MARS Gene

Gene Ontology (GO) - Molecular Function for MARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0000166 nucleotide binding --
GO:0004812 aminoacyl-tRNA ligase activity --
GO:0004825 methionine-tRNA ligase activity TAS --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MARS: view

Phenotypes for MARS Gene

GenomeRNAi human phenotypes for MARS:
genes like me logo Genes that share phenotypes with MARS: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MARS Gene

Localization for MARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MARS Gene COMPARTMENTS Subcellular localization image for MARS gene
Compartment Confidence
cytosol 4
nucleus 3
mitochondrion 2
peroxisome 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with MARS: view

Pathways for MARS Gene

genes like me logo Genes that share pathways with MARS: view

Pathways by source for MARS Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for MARS Gene

Gene Ontology (GO) - Biological Process for MARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006431 methionyl-tRNA aminoacylation IBA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with MARS: view

Compounds for MARS Gene

(6) HMDB Compounds for MARS Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
L-Methionine
  • (2S)-2-amino-4-(methylsulfanyl)butanoic acid
63-68-3
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(1) Drugbank Compounds for MARS Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Methionine
  • (S)-2-amino-4-(methylthio)butanoic acid
63-68-3 enzyme substrate

(14) Novoseek inferred chemical compound relationships for MARS Gene

Compound -log(P) Hits PubMed IDs
homocysteine thiolactone 91.7 4
methionyl adenylate 87.6 3
aminoacyl-trna 85.4 2
trna(met) 82.1 1
anticodon 77.9 5
genes like me logo Genes that share compounds with MARS: view

Transcripts for MARS Gene

Unigene Clusters for MARS Gene

Methionyl-tRNA synthetase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MARS Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - - - - - - - - - -
SP9: - - -
SP10:
SP11:
SP12: - - - - - - - - - - -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

ExUns: 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: - - - - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for MARS Gene

GeneLoc Exon Structure for
MARS
ECgene alternative splicing isoforms for
MARS

Expression for MARS Gene

mRNA expression in normal human tissues for MARS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MARS Gene

SOURCE GeneReport for Unigene cluster for MARS Gene Hs.632707

genes like me logo Genes that share expressions with MARS: view

Orthologs for MARS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MARS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARS 36
  • 99.7 (n)
  • 99.56 (a)
MARS 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MARS 36
  • 90.09 (n)
  • 92.98 (a)
MARS 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MARS 36
  • 89.98 (n)
  • 94.1 (a)
MARS 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mars 36
  • 86.89 (n)
  • 89.67 (a)
Mars 16
Mars 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MARS 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mars 36
  • 87.26 (n)
  • 91 (a)
chicken
(Gallus gallus)
Aves MARS 36
  • 66.89 (n)
  • 66.97 (a)
MARS 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MARS 37
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC69150 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mars 36
  • 66.63 (n)
  • 68.67 (a)
Str.16107 36
zebrafish
(Danio rerio)
Actinopterygii mars 36
  • 63.66 (n)
  • 64.99 (a)
mars 37
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007891 36
  • 55.04 (n)
  • 52.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15100 36
  • 54.76 (n)
  • 52.81 (a)
CG15100 37
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mars-1 37
  • 40 (a)
OneToOne
mrs-1 38
  • 60 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR332C 36
  • 55.44 (n)
  • 53.09 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MES1 36
  • 53.97 (n)
  • 52.03 (a)
MES1 37
  • 43 (a)
OneToOne
MES1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A09647g 36
  • 52.25 (n)
  • 49.51 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.795 36
rice
(Oryza sativa)
Liliopsida Os10g0400100 36
  • 58.23 (n)
  • 56.86 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07451 36
  • 54.52 (n)
  • 48.71 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rar1 36
  • 54.11 (n)
  • 52.37 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.55 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2777 37
  • 65 (a)
OneToOne
Species with no ortholog for MARS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARS Gene

ENSEMBL:
Gene Tree for MARS (if available)
TreeFam:
Gene Tree for MARS (if available)

Paralogs for MARS Gene

No data available for Paralogs for MARS Gene

Variants for MARS Gene

Sequence variations from dbSNP and Humsavar for MARS Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs474544 -- 57,495,807(+) cagcc(C/T)ggcca intron-variant
rs474738 -- 57,495,865(+) tgtgg(C/T)ggcgc intron-variant
rs496245 -- 57,497,713(+) GTGAG(C/G)TCTTT intron-variant
rs537161 -- 57,498,021(+) GGGTT(C/T)GTGTG intron-variant
rs776038 -- 57,499,016(+) cagtg(G/T)ctcat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARS Gene

Variant ID Type Subtype PubMed ID
nsv899117 CNV Loss 21882294
nsv899118 CNV Gain 21882294
dgv513e1 CNV Complex 17122850
nsv428283 CNV Gain 18775914
nsv469411 CNV Loss 19166990
nsv899119 CNV Loss 21882294
nsv819781 CNV Loss 19587683
nsv899120 CNV Loss 21882294
esv1408918 CNV Insertion 17803354

Relevant External Links for MARS Gene

HapMap Linkage Disequilibrium report
MARS
Human Gene Mutation Database (HGMD)
MARS

Disorders for MARS Gene

(1) OMIM Diseases for MARS Gene (156560)

UniProtKB/Swiss-Prot

SYMC_HUMAN
  • Infantile liver failure syndrome 2 (ILFS2) [MIM:615486]: A life-threatening disorder of hepatic function that manifests with liver failure in the first months of life. Clinical features include failure to thrive, hypotonia, intermittent lactic acidosis, aminoaciduria, hypothyroidism, interstitial lung disease, anemia, liver canalicular cholestasis, steatosis, and iron deposition. {ECO:0000269 PubMed:24103465}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for MARS Gene

(1) Novoseek inferred disease relationships for MARS Gene

Disease -log(P) Hits PubMed IDs
tuberculosis 0 3

Relevant External Links for MARS

Genetic Association Database (GAD)
MARS
Human Genome Epidemiology (HuGE) Navigator
MARS
genes like me logo Genes that share disorders with MARS: view

Publications for MARS Gene

  1. Cloning of a human cDNA encoding a protein with high homology to yeast methionyl-tRNA synthetase. (PMID: 8921912) Lage H. … Dietel M. (Gene 1996) 3 4 23
  2. CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability. (PMID: 10448063) Ubeda M. … Habener J.F. (Biochem. Biophys. Res. Commun. 1999) 2 3 23
  3. Genetic dissection of protein-protein interactions in multi-tRNA synthetase complex. (PMID: 10200289) Rho S.B. … Shiba K. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 23
  4. Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis. (PMID: 10791971) Ko Y.G. … Kim S. (J. Cell Biol. 2000) 3 23
  5. The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function. (PMID: 11714285) Kaminska M. … Mirande M. (Biochemistry 2001) 3 23

Products for MARS Gene

  • Addgene plasmids for MARS

Sources for MARS Gene

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