MARK4 Gene

Aliases
for MARK4 gene

Previous GC identifers: GC19P046399 GC19P046145 GC19P050430 GC19P050446 GC19P045754 GC19P042186

Summaries
for MARK4 gene

Genomic Views
for MARK4 gene

RefSeq DNA sequence:

NC_000019.9  NC_018930.1  NT_011109.16  

SwitchGear Promoter luciferase reporter plasmid: MARK4 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARK4

MARK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045583:  view genomic region     (about GC identifiers)

Proteins
for MARK4 gene

Explore the universe of human proteins at neXtProt for MARK4: NX_Q96L34

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: MARK4 OriGene Custom Protein Services for MARK4
	GenScript Custom Purified and Recombinant Proteins Services for MARK4
	Novus Biologicals MARK4 Protein Novus Biologicals MARK4 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MARK4

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MARK4
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for MARK4
	OriGene Antibodies: MARK4 OriGene Custom Antibody Services for MARK4
	GenScript Custom Superior Antibodies Services for MARK4
	Novus Biologicals MARK4 Antibodies
	Search for Antibodies for MARK4 at Abcam
	Uscn Antibodies for MARK4
	ThermoFisher Antibodies for MARK4

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MARK4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MARK4

Protein Domains /
Families
for MARK4 gene

ProtoNet protein and cluster: Q96L34

Function
for MARK4 gene

Enzyme Numbers (IUBMB): EC 2.7.11.1^{1 2} EC 2.7.11²

miRNA Products:		OriGene 3'-UTR Clone: MARK4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARK4
		8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate MARK4 (see all 46):
		hsa-miR-3194-5p hsa-miR-4328 hsa-miR-1914* hsa-miR-106a hsa-let-7a-2* hsa-miR-624 hsa-miR-486-3p hsa-miR-764
		SwitchGear 3'UTR luciferase reporter plasmid: MARK4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MARK4 (see all 4) OriGene shRNA RFP: MARK4 OriGene siRNA: MARK4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARK4

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for MARK4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MARK4 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MARK4 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MARK4 (NM_001199867)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARK4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARK4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MARK4
		Search LifeMap BioReagents cell lines for MARK4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARK4

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

(inferred from 1 allele) (MGI details for Mark4)

Pathways & Interactions
for MARK4 gene

	Super-pathway	contained gene-specific pathways
1	LKB1 signaling events	LKB1 signaling events 1.00
2	Cytoskeletal Signaling	Cytoskeletal Signaling 1.00
3	Cytoskeleton remodeling Neurofilaments	Cytoplasmic microtubules 0.32

1 EMD Millipore Pathway for MARK4

Cytoplasmic microtubules

1 Cell Signaling Technology (CST) Pathway for MARK4

Cytoskeletal Signaling

1 BioSystems Pathway for MARK4

LKB1 signaling events

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

Drugs & Compounds
for MARK4 gene

Transcripts
for MARK4 gene

Expression
for MARK4 gene

MARK4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTACACTGGA

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BoneMandibular Process			Bone
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MARK4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MARK4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARK4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARK4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARK4

Orthologs
for MARK4 gene

Paralogs
for MARK4 gene

Paralogs for MARK4 gene

BRSK1²  NUAK1²  MARK1²  BRSK2²  SIK3²  SNRK²  SIK2²  NUAK2²  

MARK2²  NIM1²  SIK1²  MARK3²  

18/189 SIMAP similar genes for MARK4 using alignment to 5 protein entries:     MARK4_HUMAN (see all proteins) (see all similar genes):

Nbla00650    MARK3    MARK2    KIAA0999    Par1b    MARK1

SIK3    BRSK2    PKN1    PRKAA1    PRKG2    TRIB3

PRKCZ    PRKG1    PRKCI    PRKCQ    SNRK    CHEK1

MARK4 for paralogs           About GeneDecksing


4 Pseudogenes.org Pseudogenes for MARK4
PGOHUM00000237760 PGOHUM00000263120 PGOHUM00000237945 PGOHUM00000237946

Genomic Variants
for MARK4 gene

10/1000 NCBI SNPs in MARK4 are shown (see all 1000)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1892759851,2		--	45752792(+)	GAGGCC/TGAAGT	2	--	us2k1		0	--	--	--	--
rs792395901,2	C,	--	45752806(+)	AGGATC/TGCCTG	2	--	us2k1		2		WA	120
rs1813053461,2		--	45752866(+)	CTGGGC/TGTGGT	2	--	us2k1		0	--	--	--	--
rs730365241,2	C,	--	45752898(+)	TGACTC/TGGTGG	2	--	us2k1		0	--	--	--	--
rs1453665881,2		--	45752918(+)	GGGAGG/TATTGC	2	--	us2k1		0	--	--	--	--
rs796304071,2	C,	--	45753005(+)	CTGTCT/CCAAAA	2	--	us2k1		2		WA	120
rs344030061,2	C	--	45753071(+)	GGAGCC/TTTAAT	2	--	us2k1		0	--	--	--	--
rs1476871421,2		--	45753144(+)	AGGTGA/GTATCA	2	--	us2k1		0	--	--	--	--
rs1408491781,2		--	45753204(+)	ATAGAC/TGTAGG	2	--	us2k1		0	--	--	--	--
rs1448113241,2		--	45753208(+)	ACGTAA/GGTAAC	2	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for MARK4 (45582546 - 45808541 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MARK4
     2 CNVs: 5103 5343

SABiosciences Cancer Mutation PCR Assays

1 SABiosciences qBiomarker Copy Number PCR Array containing MARK4: WNT Signaling

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MARK4

DNA2.0 Custom Variant and Variant Library Synthesis for MARK4

Disorders / Diseases
for MARK4 gene

Publications
for MARK4 gene

PubMed articles for MARK4 gene, integrated from 9 sources (see all 32): (articles sorted by number of sources associating them with MARK4)

Utopia: connect your pdf to the dynamic world of online information

1. Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis. (PubMed id 11326310)^{1, 2, 3, 9} Kato T.... Furukawa Y. (2001)
2. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. (PubMed id 18254724)^{1, 2} Al-Hakim A.K....Alessi D.R. (2008)
3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
4. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)^{1, 2} Lizcano J.M....Alessi D.R. (2004)
5. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)^{1, 2} Nagase T.... Ohara O. (2001)
6. MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. (PubMed id 9108484)^{1, 3} Drewes G....Mandelkow E. (1997)
7. The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines. (PubMed id 12735302)^{1, 9} Beghini A....Larizza L. (2003)
8. Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. (PubMed id 14676191)^{1, 9} Brajenovic M.... Drewes G. (2004)
9. Investigation of two Wnt signalling pathway single nuc leotide polymorphisms in a breast cancer-affected Australian population. (PubMed id 22506312)¹ Gabrovska P.N....Griffiths L.R. (2011)
10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)

External Searches for MARK4 gene

Genome Databases showing MARK4 gene

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Specialized Databases showing MARK4 gene

Products
for MARK4 gene