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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MARK4 Gene

protein-coding   GIFtS: 64
GCID: GC19P045583

MAP/Microtubule Affinity-Regulating Kinase 4

(Previous name: MAP/microtubule affinity-regulating kinase like 1)
(Previous symbol: MARKL1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MAP/Microtubule Affinity-Regulating Kinase 41 2     MARK4S2
MARKL11 2 3 5     MARKL1L2
MAP/Microtubule Affinity-Regulating Kinase Like 11 2     PAR-1D2
EC 2.7.11.13 8     MARK4 Serine/Threonine Protein Kinase2
KIAA18603 5     MAP/Microtubule Affinity-Regulating Kinase-Like 13
MARK4L2     EC 2.7.118

External Ids:    HGNC: 135381   Entrez Gene: 577872   Ensembl: ENSG000000070477   OMIM: 6064955   UniProtKB: Q96L343   

Export aliases for MARK4 gene to outside databases

Previous GC identifers: GC19P046399 GC19P046145 GC19P050430 GC19P050446 GC19P045754 GC19P042186


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MARK4 Gene:
This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases
phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic
microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in
cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also
play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of
chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this
gene. (provided by RefSeq, Dec 2010)

GeneCards Summary for MARK4 Gene: 
MARK4 (MAP/microtubule affinity-regulating kinase 4) is a protein-coding gene. Diseases associated with MARK4 include fatal familial insomnia, and peutz-jeghers syndrome, and among its related super-pathways are Cytoskeleton remodeling Neurofilaments. GO annotations related to this gene include ubiquitin binding and protein serine/threonine kinase activity. An important paralog of this gene is NUAK1.

Gene Wiki entry for MARK4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MARK4 gene promoter:
         ISGF-3   SREBP-1c   Meis-1b   SREBP-1b   SREBP-1a   NRF-2   SEF-1 (1)   IRF-7A   LyF-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMARK4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MARK4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.2

MARK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARK4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045583:  view genomic region     (about GC identifiers)

Start:
45,582,546 bp from pter      End:
45,808,541 bp from pter
Size:
225,996 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MARK4_HUMAN, Q96L34 (See protein sequence)
Recommended Name: MAP/microtubule affinity-regulating kinase 4  
Size: 752 amino acids; 82520 Da
Sequence caution: Sequence=BAB47489.1; Type=Erroneous initiation; Sequence=BAB55238.1; Type=Erroneous initiation;
Secondary accessions: Q8NG37 Q96JG7 Q96SQ2 Q9BYD8
Alternative splicing: 2 isoforms:  Q96L34-1   Q96L34-2   

Explore the universe of human proteins at neXtProt for MARK4: NX_Q96L34

Explore proteomics data for MARK4 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated with 'Lys-29'- and 'Lys-33'-linked polyubiquitins which appear to impede LKB1-mediated
    phosphorylation. Deubiquitinated by USP9X
  • UniProtKB: Phosphorylated at Thr-214 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and
    CAB39
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96L34

  • 4/21 DME Specific Peptides for MARK4 (Q96L34) (see all 21)
     FRQIVSA  FAKVKLA  RQIVSAV  LTGREVA 

    MARK4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MARK4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001186796.1  NP_113605.2  

    ENSEMBL proteins: 
     ENSP00000465414   ENSP00000262891   ENSP00000300843   ENSP00000466702   ENSP00000465613  
     ENSP00000466843  

    Human Recombinant Protein Products for MARK4: 
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    Novus Biologicals MARK4 Protein
    Novus Biologicals MARK4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MARK4 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA14594945
    GO:0005815microtubule organizing center IDA14594945
    GO:0015630microtubule cytoskeleton IDA14594945
    GO:0043005neuron projection IDA14594945

    MARK4 for ontologies           About GeneDecksing



    MARK4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MARK4
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    Novus Biologicals MARK4 Antibodies
    Abcam antibodies for MARK4
    Cloud-Clone Corp. Antibodies for MARK4 
    ThermoFisher Antibodies for MARK4
    LSBio Antibodies in human, mouse, rat for MARK4 

    Assay Products for MARK4: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MARK4 
    Cloud-Clone Corp. CLIAs for MARK4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: MAP/microtubule affinity-regulating kinase 4 
    MARK subfamily

    5/8 InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR001772 KA1_dom
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q96L34

    ProtoNet protein and cluster: Q96L34

    2 Blocks protein domains:
    IPB000449 Ubiquitin-associated domain
    IPB001772 Kinase-associated


    UniProtKB/Swiss-Prot: MARK4_HUMAN, Q96L34
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily
    Similarity: Contains 1 KA1 (kinase-associated) domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UBA domain


    MARK4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARK4_HUMAN, Q96L34
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-214

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA15009667
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI14594945
    GO:0005524ATP binding NAS15009667
         
    MARK4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MARK4:
     Decreased focal adhesion (FA)   Increased cell death HMECs cel 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mark4):
     adipose tissue  behavior/neurological  growth/size  homeostasis/metabolism 

    MARK4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MARK4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MARK4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARK4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARK4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARK4
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate MARK4 (see all 46):
    hsa-miR-3194-5p hsa-miR-4328 hsa-miR-1914* hsa-miR-106a hsa-let-7a-2* hsa-miR-624 hsa-miR-486-3p hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmidMARK4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): MARK4 (NM_001199867)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARK4
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                         Customized lentivirus expression plasmids for stable overexpression of MARK4 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARK4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MARK4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytoskeleton remodeling Neurofilaments
    Cytoplasmic microtubules0.32
    2LKB1 signaling events
    LKB1 signaling events
    3Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MARK4
        Cytoplasmic microtubules


    1 Cell Signaling Technology (CST) Pathway for MARK4
        Cytoskeletal Signaling

    1 BioSystems Pathway for MARK4
        LKB1 signaling events



    MARK4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MARK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/98 Interacting proteins for MARK4 (Q96L341, 3 ENSP000003008434) via UniProtKB, MINT, STRING, and/or I2D (see all 98)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK11Q158311, 3, ENSP000003248564EBI-302319,EBI-306838 I2D: score=4 STRING: ENSP00000324856
    ENSG00000232575P074373, ENSP000004100714I2D: score=2 STRING: ENSP00000410071
    ENSG00000235067P074373, ENSP000004013174I2D: score=2 STRING: ENSP00000401317
    ENSG00000183311P074373I2D: score=2 
    ENSG00000224156P074373I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IMP14594945
    GO:0001578microtubule bundle formation IEP14594945
    GO:0006468protein phosphorylation TAS14594945
    GO:0007399nervous system development IDA14594945
    GO:0043068positive regulation of programmed cell death NAS15009667

    MARK4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MARK4

    2 HMDB Compounds for MARK4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about MARK4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MARK4 gene (2 alternative transcripts): 
    NM_001199867.1  NM_031417.3  

    Unigene Cluster for MARK4:

    MAP/microtubule affinity-regulating kinase 4
    Hs.34314  [show with all ESTs]
    Unigene Representative Sequence: NM_031417
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587566 ENST00000262891(uc002paz.2 uc002pbb.2 uc002pbc.1)
    ENST00000300843(uc002pba.2) ENST00000592762 ENST00000590909 ENST00000588533
    ENST00000588621 ENST00000592207 ENST00000590897

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARK4
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate MARK4 (see all 46):
    hsa-miR-3194-5p hsa-miR-4328 hsa-miR-1914* hsa-miR-106a hsa-let-7a-2* hsa-miR-624 hsa-miR-486-3p hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmidMARK4 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARK4
    Clone
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    OriGene clones in human, mouse for MARK4 (see all 8)
    OriGene ORF clones in mouse, rat for MARK4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MARK4 (NM_001199867)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARK4
    Sirion Biotech Customized lentivirus for stable overexpression of MARK4 
                         Customized lentivirus expression plasmids for stable overexpression of MARK4 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MARK4
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARK4

    Additional mRNA sequence: 

    AB049127.1 AB058763.1 AB073663.1 AB088047.1 AK027619.1 AK074578.1 AK075272.1 AY057448.1 
    AY120867.1 BC009049.2 

    14 DOTS entries:

    DT.100659333  DT.100778289  DT.453081  DT.97794922  DT.95269665  DT.100025848  DT.121485043  DT.100025845 
    DT.121485069  DT.121485090  DT.40206727  DT.86844643  DT.99986945  DT.95076985 

    24/172 AceView cDNA sequences (see all 172):

    BQ951442 T39826 AI784134 BI768176 AK075272 AK074578 CO246090 BP368261 
    BG389721 AB058763 CD633141 NM_031417 AJ713390 AI453416 BC071948 AI952791 
    BE257296 CD633147 CD633134 CD633133 BF940978 BM673100 BX406638 AY120867 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MARK4 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^
    SP1:                    -                                                                                                                                       
    SP2:                                                                                                                                                            
    SP3:                    -                                                                                                                                       
    SP4:        -     -     -     -     -     -     -     -                 -     -     -                 -     -     -     -     -     -     -           -         
    SP5:                                                                                                                                                            

    ExUns: 19a · 19b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for MARK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MARK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACACTGGA
    MARK4 Expression
    About this image


    See MARK4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MARK4

    SOURCE GeneReport for Unigene cluster: Hs.34314

    UniProtKB/Swiss-Prot: MARK4_HUMAN, Q96L34
    Tissue specificity: Ubiquitous. Isoform 2 is brain-specific

        SABiosciences Custom PCR Arrays for MARK4
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARK4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MARK4 gene from 7/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mark41 , 5 MAP/microtubule affinity-regulating kinase 41, 5 90.87(n)1
    97.61(a)1
      7 (9.78 cM)5
    2329441  NM_172279.11  NP_758483.11 
     194260755 
    lizard
    (Anolis carolinensis)
    Reptilia MARK46
    Uncharacterized protein
    76(a)
    1 ↔ 1
    AAWZ02037582(1094-13940)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5712791 MAP/microtubule affinity-regulating kinase 4-like 70.24(n)
    74.49(a)
      571279  XM_694854.5  XP_699946.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta KP78b3 protein amino acid phosphorylation
    protein kinase
    63(a)
    (best of 4)
      86E4   --
    worm
    (Caenorhabditis elegans)
    Secernentea kin-293 serine/threonine-protein kinase 42(a)
    (best of 7)
      X(2880113-2887689)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YPL150W)4 Putative protein kinase of unknown cellular role; binds more   --   16(268188-270893) 855953  NP_015175.1 
    corn
    (Zea mays)
    Liliopsida Zm.138222 Zea mays PCO131788 mRNA sequence 69.24(n)    AY104543.1 


    ENSEMBL Gene Tree for MARK4 (if available)
    TreeFam Gene Tree for MARK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MARK4 gene
    NUAK12  MARK12  PRKAA22  SNRK2  SIK32  SIK22  PRKAA12  NUAK22  
    MARK22  NIM12  SIK12  MARK32  
    18/184 SIMAP similar genes for MARK4 using alignment to 5 protein entries:     MARK4_HUMAN (see all proteins) (see all similar genes):
    Nbla00650    MARK3    KIAA0999    MARK2    Par1b    MARK1
    SIK3    BRSK2    PKN1    PRKAA1    PRKG2    TRIB3
    PRKCZ    PRKG1    PRKCI    PRKCQ    SNRK    CHEK1

    MARK4 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for MARK4
    PGOHUM00000237760 PGOHUM00000263120 PGOHUM00000237945 PGOHUM00000237946


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1280 SNPs in MARK4 are shown (see all 1280)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0407674
    A colorectal adenocarcinoma sample4--see VAR_0407672 R C mis40--------
    rs1892759851,2
    C--45752792(+) GAGGCC/TGAAGT 2 -- us2k10--------
    rs792395901,2
    C,F--45752806(+) AGGATC/TGCCTG 2 -- us2k12Minor allele frequency- T:0.04WA 120
    rs1813053461,2
    --45752866(+) CTGGGC/TGTGGT 2 -- us2k10--------
    rs730365241,2
    C--45752898(+) TGACTC/TGGTGG 2 -- us2k10--------
    rs1453665881,2
    C--45752918(+) GGGAGG/TATTGC 2 -- us2k10--------
    rs796304071,2
    C,F--45753005(+) CTGTCT/CCAAAA 2 -- us2k12Minor allele frequency- C:0.06WA 120
    rs344030061,2
    C--45753071(+) GGAGCC/TTTAAT 2 -- us2k10--------
    rs1476871421,2
    --45753144(+) AGGTGA/GTATCA 2 -- us2k10--------
    rs1408491781,2
    C--45753204(+) ATAGAC/TGTAGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MARK4 (45582546 - 45808541 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MARK4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422482CNV Duplication17116639
    nsv912143CNV Loss21882294
    nsv833844CNV Loss17160897
    nsv912146CNV Loss21882294
    nsv833843CNV Loss17160897
    nsv912145CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for MARK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606495    OMIM disorders: --

    7 diseases for MARK4:    About MalaCards
    fatal familial insomnia    peutz-jeghers syndrome    alzheimer's disease    glioblastoma
    cerebritis    neuronitis    breast cancer


    MARK4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): MARK4
    Human Genome Epidemiology (HuGE) Navigator: MARK4 (2 documents)

    Export disorders for MARK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MARK4 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with MARK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis. (PubMed id 11326310)1, 2, 3, 9 Kato T.... Furukawa Y. (2001)
    2. The microtubule affinity regulating kinase MARK4 promo tes axoneme extension during early ciliogenesis. (PubMed id 23400999)1, 3 Kuhns S....Pereira G. (2013)
    3. Genome-wide analysis of genetic loci associated with Alzheimer disease. (PubMed id 20460622)1, 4 Seshadri S....Breteler M.M. (2010)
    4. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    5. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. (PubMed id 18254724)1, 2 Al-Hakim A.K....Alessi D.R. (2008)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)1, 2 Lizcano J.M....Alessi D.R. (2004)
    8. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
    9. MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. (PubMed id 9108484)1, 3 Drewes G....Mandelkow E. (1997)
    10. The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines. (PubMed id 12735302)1, 9 Beghini A....Larizza L. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57787 HGNC: 13538 AceView: MARK4 Ensembl:ENSG00000007047 euGenes: HUgn57787
    ECgene: MARK4 H-InvDB: MARK4

    (According to HUGE)
    About This Section
    HUGE: KIAA1860

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MARK4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MARK4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MARK4 gene:
    Search GeneIP for patents involving MARK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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