Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MARK4 Gene

protein-coding   GIFtS: 64
GCID: GC19P045583

MAP/Microtubule Affinity-Regulating Kinase 4

(Previous name: MAP/microtubule affinity-regulating kinase like 1)
(Previous symbol: MARKL1)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
MAP/Microtubule Affinity-Regulating Kinase 41 2     MARK4S2
MARKL11 2 3 5     MARKL1L2
MAP/Microtubule Affinity-Regulating Kinase Like 11 2     PAR-1D2
EC 2.7.11.13 8     MARK4 Serine/Threonine Protein Kinase2
KIAA18603 5     MAP/Microtubule Affinity-Regulating Kinase-Like 13
MARK4L2     EC 2.7.118

External Ids:    HGNC: 135381   Entrez Gene: 577872   Ensembl: ENSG000000070477   OMIM: 6064955   UniProtKB: Q96L343   

Export aliases for MARK4 gene to outside databases

Previous GC identifers: GC19P046399 GC19P046145 GC19P050430 GC19P050446 GC19P045754 GC19P042186


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MARK4 Gene:
This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases
phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic
microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in
cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also
play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of
chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this
gene. (provided by RefSeq, Dec 2010)

GeneCards Summary for MARK4 Gene:
MARK4 (MAP/microtubule affinity-regulating kinase 4) is a protein-coding gene. GO annotations related to this gene include ubiquitin binding and protein serine/threonine kinase activity. An important paralog of this gene is BRSK1.

Gene Wiki entry for MARK4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MARK4 gene promoter:
         ISGF-3   SREBP-1c   Meis-1b   SREBP-1b   SREBP-1a   NRF-2   SEF-1 (1)   IRF-7A   LyF-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMARK4 promoter sequence
   Search Chromatin IP Primers for MARK4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.2

MARK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARK4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045583:  view genomic region     (about GC identifiers)

Start:
45,582,546 bp from pter      End:
45,808,541 bp from pter
Size:
225,996 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MARK4_HUMAN, Q96L34 (See protein sequence)
Recommended Name: MAP/microtubule affinity-regulating kinase 4  
Size: 752 amino acids; 82520 Da
Sequence caution: Sequence=BAB47489.1; Type=Erroneous initiation; Sequence=BAB55238.1; Type=Erroneous initiation;
Secondary accessions: Q8NG37 Q96JG7 Q96SQ2 Q9BYD8
Alternative splicing: 2 isoforms:  Q96L34-1   Q96L34-2   

Explore the universe of human proteins at neXtProt for MARK4: NX_Q96L34

Explore proteomics data for MARK4 at MOPED

Post-translational modifications: 

  • Ubiquitinated with 'Lys-29'- and 'Lys-33'-linked polyubiquitins which appear to impede LKB1-mediated
    phosphorylation. Deubiquitinated by USP9X1
  • Phosphorylated at Thr-214 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and
    CAB391
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MARK4 (Q96L34) (see all 21)
     FRQIVSA  FAKVKLA  RQIVSAV  LTGREVA 


    See MARK4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186796.1  NP_113605.2  

    ENSEMBL proteins: 
     ENSP00000465414   ENSP00000262891   ENSP00000300843   ENSP00000466702   ENSP00000465613  
     ENSP00000466843  

    MARK4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MARK4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MARK4
    GenScript Custom Purified and Recombinant Proteins Services for MARK4
    Novus Biologicals MARK4 Protein
    Novus Biologicals MARK4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MARK4

     
    Search eBioscience for Proteins for MARK4 

    MARK4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MARK4
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for MARK4 
    OriGene Antibodies for MARK4
    OriGene Custom Antibody Services for MARK4
    Novus Biologicals MARK4 Antibodies
    Abcam antibodies for MARK4 (Q9P0L2, Q96L34)
    Cloud-Clone Corp. Antibodies for MARK4
    ThermoFisher Antibodies for MARK4
    LSBio Antibodies in human, mouse, rat for MARK4

    MARK4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MARK4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MARK4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MARK4
    Cloud-Clone Corp. CLIAs for MARK4
    Search eBioscience for ELISAs for MARK4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: MAP/microtubule affinity-regulating kinase 4
    MARK subfamily

    Selected InterPro protein domains (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR001772 KA1_dom
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q96L34

    ProtoNet protein and cluster: Q96L34

    2 Blocks protein domains:
    IPB000449 Ubiquitin-associated domain
    IPB001772 Kinase-associated


    UniProtKB/Swiss-Prot: MARK4_HUMAN, Q96L34
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily
    Similarity: Contains 1 KA1 (kinase-associated) domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UBA domain


    Find genes that share domains with MARK4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARK4_HUMAN, Q96L34
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-214

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA15009667
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI14594945
    GO:0005524ATP binding NAS15009667
         
    Find genes that share ontologies with MARK4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MARK4:
     Decreased focal adhesion (FA)   Increased cell death HMECs cel 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mark4):
     adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism 

    Find genes that share phenotypes with MARK4           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MARK4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MARK4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARK4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARK4

    miRNA
    Products:
        
    miRTarBase miRNAs that target MARK4:
    hsa-mir-30c-5p (MIRT047961), hsa-mir-335-5p (MIRT018631)

    Block miRNA regulation of human, mouse, rat MARK4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MARK4 (see all 46):
    hsa-miR-3194-5p hsa-miR-4328 hsa-miR-1914* hsa-miR-106a hsa-let-7a-2* hsa-miR-624 hsa-miR-486-3p hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmidMARK4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MARK4
    Predesigned siRNA for gene silencing in human, mouse, rat MARK4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MARK4

    Clone
    Products:
         
    OriGene clones in human, mouse for MARK4 (see all 7)
    OriGene ORF clones in mouse, rat for MARK4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MARK4 (NM_001199867)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARK4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MARK4
    Browse ESI BIO Cell Lines and PureStem Progenitors for MARK4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARK4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA14594945
    GO:0005815microtubule organizing center IDA14594945
    GO:0015630microtubule cytoskeleton IDA14594945
    GO:0043005neuron projection IDA14594945

    Find genes that share ontologies with MARK4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MARK4 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    2LKB1 signaling events
    LKB1 signaling events
    3Cytoskeletal Signaling
    Cytoskeletal Signaling


    Find genes that share SuperPaths with MARK4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MARK4
        Cytoskeletal Signaling

    1 BioSystems Pathway for MARK4
        LKB1 signaling events


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MARK4
    Interactions:

        GeneGlobe Interaction Network for MARK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MARK4 (Q96L341, 3 ENSP000003008434) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK11Q158311, 3, ENSP000003248564EBI-302319,EBI-306838 I2D: score=4 STRING: ENSP00000324856
    ENSG00000232575P074373, ENSP000004100714I2D: score=2 STRING: ENSP00000410071
    ENSG00000235067P074373, ENSP000004013174I2D: score=2 STRING: ENSP00000401317
    ENSG00000183311P074373I2D: score=2 
    ENSG00000224156P074373I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IMP14594945
    GO:0001578microtubule bundle formation IEP14594945
    GO:0006468protein phosphorylation TAS14594945
    GO:0007399nervous system development IDA14594945
    GO:0043068positive regulation of programmed cell death NAS15009667

    Find genes that share ontologies with MARK4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MARK4

    2 HMDB Compounds for MARK4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MARK4 gene (2 alternative transcripts): 
    NM_001199867.1  NM_031417.3  

    Unigene Cluster for MARK4:

    MAP/microtubule affinity-regulating kinase 4
    Hs.34314  [show with all ESTs]
    Unigene Representative Sequence: NM_031417
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587566 ENST00000262891(uc002paz.2 uc002pbb.2 uc002pbc.1)
    ENST00000300843(uc002pba.2) ENST00000592762 ENST00000590909 ENST00000588533
    ENST00000588621 ENST00000592207 ENST00000590897
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MARK4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MARK4 (see all 46):
    hsa-miR-3194-5p hsa-miR-4328 hsa-miR-1914* hsa-miR-106a hsa-let-7a-2* hsa-miR-624 hsa-miR-486-3p hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmidMARK4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MARK4
    Predesigned siRNA for gene silencing in human, mouse, rat MARK4
    Clone
    Products:
         
    OriGene clones in human, mouse for MARK4 (see all 7)
    OriGene ORF clones in mouse, rat for MARK4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MARK4 (NM_001199867)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARK4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MARK4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARK4
      QuantiTect SYBR Green Assays in human, mouse, rat MARK4
      QuantiFast Probe-based Assays in human, mouse, rat MARK4

    Additional mRNA sequence: 

    AB049127.1 AB058763.1 AB073663.1 AB088047.1 AK027619.1 AK074578.1 AK075272.1 AY057448.1 
    AY120867.1 BC009049.2 

    14 DOTS entries:

    DT.100659333  DT.100778289  DT.453081  DT.97794922  DT.95269665  DT.100025848  DT.121485043  DT.100025845 
    DT.121485069  DT.121485090  DT.40206727  DT.86844643  DT.99986945  DT.95076985 

    Selected AceView cDNA sequences (see all 172):

    AI453416 BG389721 BQ951442 AJ713390 CD633134 AK075272 T39826 CO246090 
    NM_031417 CD633141 BE257296 BI768176 AI784134 CD633147 BP368261 BC071948 
    AI952791 AB058763 CD633133 AK074578 AW051999 CD633131 AI272168 BQ709130 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MARK4 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^
    SP1:                    -                                                                                                                                       
    SP2:                                                                                                                                                            
    SP3:                    -                                                                                                                                       
    SP4:        -     -     -     -     -     -     -     -                 -     -     -                 -     -     -     -     -     -     -           -         
    SP5:                                                                                                                                                            

    ExUns: 19a · 19b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for MARK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MARK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACACTGGA
    MARK4 Expression
    About this image

    MARK4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MARK4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.34314

    UniProtKB/Swiss-Prot: MARK4_HUMAN, Q96L34
    Tissue specificity: Ubiquitous. Isoform 2 is brain-specific

        Custom PCR Arrays for MARK4
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MARK4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARK4
    QuantiTect SYBR Green Assays in human, mouse, rat MARK4
    QuantiFast Probe-based Assays in human, mouse, rat MARK4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MARK4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mark41 , 5 MAP/microtubule affinity-regulating kinase 41, 5 90.87(n)1
    97.61(a)1
      7 (9.78 cM)5
    2329441  NM_172279.11  NP_758483.11 
     194260755 
    lizard
    (Anolis carolinensis)
    Reptilia MARK46
    MAP/microtubule affinity-regulating kinase 4
    78(a)
    1 ↔ 1
    AAWZ02037582(1094-13940)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mark41 MAP/microtubule affinity-regulating kinase 4 66.34(n)
    73.74(a)
      100491038  XM_002932636.2  XP_002932682.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-31m14.71 si:dkey-31m14.7 71.28(n)
    74.76(a)
      571279  XM_005157599.1  XP_005157656.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta KP78b3 protein amino acid phosphorylation
    protein kinase
    63(a)
    (best of 4)
      86E4   --
    worm
    (Caenorhabditis elegans)
    Secernentea kin-293 serine/threonine-protein kinase 42(a)
    (best of 7)
      X(2880113-2887689)   --
    corn
    (Zea mays)
    Liliopsida Zm.138222 Zea mays PCO131788 mRNA sequence 69.24(n)    AY104543.1 


    ENSEMBL Gene Tree for MARK4 (if available)
    TreeFam Gene Tree for MARK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MARK4 gene
    BRSK12  MARK12  BRSK22  SNRK2  SIK32  SIK22  MARK22  NIM1K2  
    SIK12  MARK32  
    Selected SIMAP similar genes for MARK4 using alignment to 5 protein entries:     MARK4_HUMAN (see all proteins) (see all similar genes):
    Nbla00650    MARK3    MARK2    KIAA0999    Par1b    MARK1
    SIK3    BRSK2    PKN1    PRKAA1    PRKG2    TRIB3
    PRKCZ    PRKG1    PRKCI    PRKCQ    SNRK    CHEK1

    Find genes that share paralogs with MARK4           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for MARK4
    PGOHUM00000237760 PGOHUM00000263120 PGOHUM00000237945 PGOHUM00000237946


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MARK4 (see all 1280)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0407674
    A colorectal adenocarcinoma sample4--see VAR_0407672 R C mis40--------
    rs1892759851,2
    C--45752792(+) GAGGCC/TGAAGT 2 -- us2k10--------
    rs792395901,2
    C,F--45752806(+) AGGATC/TGCCTG 2 -- us2k12Minor allele frequency- T:0.04WA 120
    rs1813053461,2
    --45752866(+) CTGGGC/TGTGGT 2 -- us2k10--------
    rs730365241,2
    C--45752898(+) TGACTC/TGGTGG 2 -- us2k10--------
    rs1453665881,2
    C--45752918(+) GGGAGG/TATTGC 2 -- us2k10--------
    rs796304071,2
    C,F--45753005(+) CTGTCT/CCAAAA 2 -- us2k12Minor allele frequency- C:0.06WA 120
    rs344030061,2
    C--45753071(+) GGAGCC/TTTAAT 2 -- us2k10--------
    rs1476871421,2
    --45753144(+) AGGTGA/GTATCA 2 -- us2k10--------
    rs1408491781,2
    C--45753204(+) ATAGAC/TGTAGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MARK4 (45582546 - 45808541 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MARK4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422482CNV Duplication17116639
    nsv912143CNV Loss21882294
    nsv833844CNV Loss17160897
    nsv912146CNV Loss21882294
    nsv833843CNV Loss17160897
    nsv912145CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing MARK4:
    WNT Signaling
    SeqTarget long-range PCR primers for resequencing MARK4
    DNA2.0 Custom Variant and Variant Library Synthesis for MARK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606495    OMIM disorders: --


    Find genes that share disorders with MARK4           About GenesLikeMe

    Genetic Association Database (GAD): MARK4
    Human Genome Epidemiology (HuGE) Navigator: MARK4 (2 documents)

    Export disorders for MARK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MARK4 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with MARK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis. (PubMed id 11326310)1, 2, 3, 9 Kato T.... Furukawa Y. (Neoplasia 2001)
    2. The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis. (PubMed id 23400999)1, 3 Kuhns S....Pereira G. (J. Cell Biol. 2013)
    3. Genome-wide analysis of genetic loci associated with Alzheimer disease. (PubMed id 20460622)1, 4 Seshadri S.... . (JAMA 2010)
    4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    5. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. (PubMed id 18254724)1, 2 Al-Hakim A.K....Alessi D.R. (Biochem. J. 2008)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)1, 2 Lizcano J.M....Alessi D.R. (EMBO J. 2004)
    8. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    9. MARK - a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. (PubMed id 9108484)1, 3 Drewes G.... Mandelkow E. (Cell 1997)
    10. The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines. (PubMed id 12735302)1, 9 Beghini A....Larizza L. (Oncogene 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 57787 HGNC: 13538 AceView: MARK4 Ensembl:ENSG00000007047 euGenes: HUgn57787
    ECgene: MARK4 H-InvDB: MARK4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1860

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MARK4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MARK4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MARK4 gene:
    Search GeneIP for patents involving MARK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of MARK4
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MARK4   OriGene RNAi products in human, mouse, rat for MARK4  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for MARK4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MARK4  
     OriGene qSTAR qPCR primer pairs in human, mouse for MARK4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MARK4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MARK4   OriGene Custom Protein Services for MARK4  

     
     
     Block miRNA regulation of human, mouse, rat MARK4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MARK4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARK4 Predesigned siRNA for gene silencing in human, mouse, rat MARK4
     QuantiFast Probe-based Assays in human, mouse, rat MARK4 QuantiTect SYBR Green Assays in human, mouse, rat MARK4
     Custom PCR Arrays for MARK4 Search Chromatin IP Primers for MARK4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARK4  GeneGlobe Interaction Network for MARK4
     Regulatory tfbs in MARK4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MARK4 GenScript cDNA clones with any tag delivered in your preferred vector for MARK4
     GenScript Custom Assay Services for MARK4 GenScript Custom overexpressing Cell Line Services for MARK4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for MARK4 

     Search Tocris compounds for MARK4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MARK4 antibodies
     MARK4 proteins
     MARK4 lysates
     Antibodies for MARK4
     See all of Abcam's Antibodies, Kits and Proteins for MARK4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MARK4
     Antibodies for MARK4
     ELISAs for MARK4
     CLIAs for MARK4



     Browse ESI BIO Cell Lines and PureStem Progenitors for MARK4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARK4
     SwitchGear 3'UTR luciferase reporter plasmids for MARK4
     SwitchGear Promoter luciferase reporter plasmids for MARK4
     ThermoFisher Antibodies for MARK4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARK4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MARK4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MARK4
     LSBio Antibodies in human, mouse, rat for MARK4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for MARK4
      Search eBioscience for proteins for MARK4
      Search eBioscience for elisas for MARK4
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MARK4 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4