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Aliases for MARK4 Gene

Aliases for MARK4 Gene

  • Microtubule Affinity Regulating Kinase 4 2 3 5
  • MAP/Microtubule Affinity-Regulating Kinase Like 1 2 3
  • MAP/Microtubule Affinity-Regulating Kinase 4 2 3
  • EC 2.7.11.1 4 56
  • MARKL1 3 4
  • MAP/Microtubule Affinity-Regulating Kinase-Like 1 4
  • MARK4 Serine/Threonine Protein Kinase 3
  • EC 2.7.11 56
  • KIAA1860 4
  • MARKL1L 3
  • MARK4L 3
  • MARK4S 3
  • PAR-1D 3

External Ids for MARK4 Gene

Previous HGNC Symbols for MARK4 Gene

  • MARKL1

Previous GeneCards Identifiers for MARK4 Gene

  • GC19P046399
  • GC19P046145
  • GC19P050430
  • GC19P050446
  • GC19P045754
  • GC19P042186
  • GC19P045583

Summaries for MARK4 Gene

Entrez Gene Summary for MARK4 Gene

  • This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for MARK4 Gene

MARK4 (Microtubule Affinity Regulating Kinase 4) is a Protein Coding gene. Diseases associated with MARK4 include Alzheimer Disease. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MARK3.

UniProtKB/Swiss-Prot for MARK4 Gene

  • Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942).

Gene Wiki entry for MARK4 Gene

Additional gene information for MARK4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARK4 Gene

Genomics for MARK4 Gene

GeneHancer (GH) Regulatory Elements for MARK4 Gene

Promoters and enhancers for MARK4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I045078 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.5 522 2.7 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 IRF4 SLC30A9 GEMIN7 MARK4 ZNF227 ZNF225 IRF2BP1 ZNF235 BLOC1S3 FBXO46 ZNF226 CLASRP
GH19I045250 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 570.6 +172.8 172847 2.9 HDGF YBX1 ZNF48 GLIS2 ZNF143 KLF7 SP3 NCOA1 ZNF592 ZNF610 MARK4 ZNF235 MRPS15P2 ZNF180 ZNF285 IRF2BP1 ZNF112 ERCC2 ENSG00000267114 RELB
GH19I045283 Enhancer 1 Ensembl ENCODE 45.4 +204.5 204514 1.2 BCOR ZNF146 ZNF140 BACH1 ZMYM3 BATF RELA ZNF316 ADNP NFE2 MARK4 ZNF180 CCDC61 CLASRP SYMPK QPCTL ZNF235 MRPS15P2 DM1-AS ENSG00000269148
GH19I045306 Enhancer 0.8 ENCODE dbSUPER 51.6 +227.6 227589 1.7 SCRT1 ZBTB10 KLF1 RXRA SP2 ZNF16 ZEB1 ZFHX2 NFIC POLR2A GC19M045307 MARK4 ZNF180 CEACAM19 EXOC3L2 CD3EAP PPP1R13L SNRPD2 CLASRP RELB
GH19I045320 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.3 +243.4 243360 4.7 BCOR ESRRA PKNOX1 ZMYM3 ZNF335 ZNF121 ZFHX2 POLR2A EGR1 PHF20 CKM KLC3 MARK4 ERCC2 DMPK RTN2 PPM1N CD3EAP GC19M045307
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MARK4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MARK4 gene promoter:

Genomic Locations for MARK4 Gene

Genomic Locations for MARK4 Gene
chr19:45,079,288-45,305,283
(GRCh38/hg38)
Size:
225,996 bases
Orientation:
Plus strand
chr19:45,582,546-45,808,541
(GRCh37/hg19)

Genomic View for MARK4 Gene

Genes around MARK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARK4 Gene

Proteins for MARK4 Gene

  • Protein details for MARK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L34-MARK4_HUMAN
    Recommended name:
    MAP/microtubule affinity-regulating kinase 4
    Protein Accession:
    Q96L34
    Secondary Accessions:
    • Q8NG37
    • Q96JG7
    • Q96SQ2
    • Q9BYD8

    Protein attributes for MARK4 Gene

    Size:
    752 amino acids
    Molecular mass:
    82520 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with gamma-tubulin (PubMed:14594945). Interacts with ODF2 (PubMed:23400999). Interacts with USP9X (PubMed:18254724).
    SequenceCaution:
    • Sequence=BAB47489.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55238.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MARK4 Gene

    Alternative splice isoforms for MARK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARK4 Gene

Selected DME Specific Peptides for MARK4 Gene

Q96L34:
  • SLQKLFREVRIMK
  • EVDIWSLG
  • LTGREVA
  • TIGKGNFA
  • GARCRNSIASC
  • KIIDKTQL
  • RRNTYVC
  • FRQIVSA
  • FAKVKLA
  • GPEVDIWS
  • WSLGVILY
  • RQIVSAV
  • NLKELRERVLRGKYR
  • VAIKIID
  • GEVFDYLV
  • DFGFSNEFT
  • WSLGVILYTLVSGSLPFDG
  • LNHPNIVKLFEVIETEKTLYL
  • GSPPYAAPE
  • NHPNIVKL
  • IVHRDLK

Post-translational modifications for MARK4 Gene

  • Phosphorylated at Thr-214 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39 (PubMed:14976552). Phosphorylated throughout the cell cycle (PubMed:25123532).
  • Ubiquitinated with Lys-29- and Lys-33-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation. Deubiquitinated by USP9X.

Domains & Families for MARK4 Gene

Gene Families for MARK4 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for MARK4 Gene

Graphical View of Domain Structure for InterPro Entry

Q96L34

UniProtKB/Swiss-Prot:

MARK4_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with MARK4: view

Function for MARK4 Gene

Molecular function for MARK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-214.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942).

Enzyme Numbers (IUBMB) for MARK4 Gene

Phenotypes From GWAS Catalog for MARK4 Gene

Gene Ontology (GO) - Molecular Function for MARK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity NAS,IDA 15009667
GO:0005515 protein binding IPI 14594945
GO:0005524 ATP binding NAS,IEA 15009667
genes like me logo Genes that share ontologies with MARK4: view
genes like me logo Genes that share phenotypes with MARK4: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MARK4 Gene

Localization for MARK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARK4 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm. Note=Localized at the tips of neurite-like processes in differentiated neuroblast cells. Detected in the cytoplasm and neuropil of the hippocampus. {ECO:0000269 PubMed:14594945, ECO:0000269 PubMed:23666762}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARK4 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MARK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000930 gamma-tubulin complex IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 14594945
GO:0005815 microtubule organizing center IDA 14594945
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MARK4: view

Pathways & Interactions for MARK4 Gene

genes like me logo Genes that share pathways with MARK4: view

Pathways by source for MARK4 Gene

1 Cell Signaling Technology pathway for MARK4 Gene
1 BioSystems pathway for MARK4 Gene

SIGNOR curated interactions for MARK4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MARK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle NAS --
GO:0000226 microtubule cytoskeleton organization IEA,IMP 14594945
GO:0001578 microtubule bundle formation IEP 14594945
GO:0006468 protein phosphorylation TAS,NAS 14594945
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with MARK4: view

Drugs & Compounds for MARK4 Gene

(1) Drugs for MARK4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for MARK4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MARK4: view

Transcripts for MARK4 Gene

Unigene Clusters for MARK4 Gene

MAP/microtubule affinity-regulating kinase 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARK4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^
SP1: -
SP2:
SP3: -
SP4: - - - - - - - - - - - - - - - - - - -
SP5:
SP6: -
SP7: - -
SP8:

ExUns: 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for MARK4 Gene

GeneLoc Exon Structure for
MARK4
ECgene alternative splicing isoforms for
MARK4

Expression for MARK4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MARK4 Gene

Protein differential expression in normal tissues from HIPED for MARK4 Gene

This gene is overexpressed in Fetal Brain (19.4), Frontal cortex (14.2), Testis (12.6), Retina (11.5), and Brain (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MARK4 Gene



Protein tissue co-expression partners for MARK4 Gene

NURSA nuclear receptor signaling pathways regulating expression of MARK4 Gene:

MARK4

SOURCE GeneReport for Unigene cluster for MARK4 Gene:

Hs.34314

mRNA Expression by UniProt/SwissProt for MARK4 Gene:

Q96L34-MARK4_HUMAN
Tissue specificity: Ubiquitous. Isoform 2 is brain-specific (PubMed:11326310). Expressed at highest levels in brain and testis. Also expressed in heart, lung, liver, muscle, kidney and spleen (PubMed:14594945).

Evidence on tissue expression from TISSUES for MARK4 Gene

  • Nervous system(4.7)
  • Thyroid gland(4.2)
genes like me logo Genes that share expression patterns with MARK4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARK4 Gene

Orthologs for MARK4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MARK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARK4 33 34
  • 99.51 (n)
cow
(Bos Taurus)
Mammalia MARK4 33 34
  • 95.37 (n)
dog
(Canis familiaris)
Mammalia MARK4 33 34
  • 94.02 (n)
mouse
(Mus musculus)
Mammalia Mark4 33 16 34
  • 90.87 (n)
rat
(Rattus norvegicus)
Mammalia Mark4 33
  • 90.82 (n)
lizard
(Anolis carolinensis)
Reptilia MARK4 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mark4 33
  • 66.34 (n)
zebrafish
(Danio rerio)
Actinopterygii MARK4 (2 of 2) 34
  • 72 (a)
OneToMany
si:dkey-31m14.7 33
  • 71.28 (n)
mark4a 34
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta KP78b 35
  • 63 (a)
KP78a 35
  • 61 (a)
CG15072 35
  • 47 (a)
par-1 34
  • 31 (a)
OneToMany
CG3105 35
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea kin-29 35
  • 42 (a)
B0511.4 35
  • 37 (a)
R02C2.1 35
  • 33 (a)
W02B12.12 35
  • 32 (a)
DC2.7a 35
  • 31 (a)
DC2.7b 35
  • 31 (a)
par-1 34
  • 29 (a)
OneToMany
F23C8.8 35
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
corn
(Zea mays)
Liliopsida Zm.13822 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
OneToMany
Species where no ortholog for MARK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARK4 Gene

ENSEMBL:
Gene Tree for MARK4 (if available)
TreeFam:
Gene Tree for MARK4 (if available)

Paralogs for MARK4 Gene

Paralogs for MARK4 Gene

genes like me logo Genes that share paralogs with MARK4: view

Variants for MARK4 Gene

Sequence variations from dbSNP and Humsavar for MARK4 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs780763668 A colorectal adenocarcinoma sample 45,280,710(+) C/A/T coding_sequence_variant, missense_variant
rs1000071618 -- 45,263,840(+) A/C intron_variant
rs1000146111 -- 45,282,715(+) C/T intron_variant
rs1000172585 -- 45,304,778(+) A/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000189526 -- 45,259,824(+) C/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MARK4 Gene

Variant ID Type Subtype PubMed ID
esv2422482 CNV duplication 17116639
nsv1071537 CNV deletion 25765185
nsv1111175 CNV tandem duplication 24896259
nsv1116335 CNV deletion 24896259
nsv1123262 CNV deletion 24896259
nsv474182 CNV novel sequence insertion 20440878
nsv833843 CNV loss 17160897
nsv833844 CNV loss 17160897

Variation tolerance for MARK4 Gene

Residual Variation Intolerance Score: 7.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MARK4 Gene

Human Gene Mutation Database (HGMD)
MARK4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MARK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARK4 Gene

Disorders for MARK4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MARK4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • ad
- elite association - COSMIC cancer census association via MalaCards
Search MARK4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MARK4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MARK4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARK4 Gene

Publications for MARK4 Gene

  1. Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis. (PMID: 11326310) Kato T … Furukawa Y (Neoplasia (New York, N.Y.) 2001) 2 3 4 22 58
  2. The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis. (PMID: 23400999) Kuhns S … Pereira G (The Journal of cell biology 2013) 2 3 4 58
  3. Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) plays a role in cell cycle progression and cytoskeletal dynamics. (PMID: 25123532) Rovina D … Larizza L (European journal of cell biology 2014) 3 4 58
  4. Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of rapamycin complex 1 (mTORC1). (PMID: 23184942) Li L … Guan KL (The Journal of biological chemistry 2013) 3 4 58
  5. Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease. (PMID: 23666762) Gu GJ … Kamali-Moghaddam M (Neuromolecular medicine 2013) 3 4 58

Products for MARK4 Gene

Sources for MARK4 Gene

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