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Aliases for MARK4 Gene

Aliases for MARK4 Gene

  • Microtubule Affinity Regulating Kinase 4 2 3
  • MAP/Microtubule Affinity-Regulating Kinase Like 1 2 3
  • MAP/Microtubule Affinity-Regulating Kinase 4 2 5
  • EC 2.7.11.1 4 63
  • MARKL1 3 4
  • MAP/Microtubule Affinity-Regulating Kinase-Like 1 4
  • MARK4 Serine/Threonine Protein Kinase 3
  • EC 2.7.11 63
  • KIAA1860 4
  • MARKL1L 3
  • MARK4L 3
  • MARK4S 3
  • PAR-1D 3

External Ids for MARK4 Gene

Previous HGNC Symbols for MARK4 Gene

  • MARKL1

Previous GeneCards Identifiers for MARK4 Gene

  • GC19P046399
  • GC19P046145
  • GC19P050430
  • GC19P050446
  • GC19P045754
  • GC19P042186
  • GC19P045583

Summaries for MARK4 Gene

Entrez Gene Summary for MARK4 Gene

  • This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for MARK4 Gene

MARK4 (Microtubule Affinity Regulating Kinase 4) is a Protein Coding gene. Diseases associated with MARK4 include Insomnia, Fatal Familial and Peutz-Jeghers Syndrome. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is LOC102724428.

UniProtKB/Swiss-Prot for MARK4 Gene

  • Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942).

Gene Wiki entry for MARK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARK4 Gene

Genomics for MARK4 Gene

Regulatory Elements for MARK4 Gene

Enhancers for MARK4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MARK4 on UCSC Golden Path with GeneCards custom track

Promoters for MARK4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MARK4 on UCSC Golden Path with GeneCards custom track

Genomic Location for MARK4 Gene

Chromosome:
19
Start:
45,079,288 bp from pter
End:
45,305,283 bp from pter
Size:
225,996 bases
Orientation:
Plus strand

Genomic View for MARK4 Gene

Genes around MARK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARK4 Gene

Proteins for MARK4 Gene

  • Protein details for MARK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L34-MARK4_HUMAN
    Recommended name:
    MAP/microtubule affinity-regulating kinase 4
    Protein Accession:
    Q96L34
    Secondary Accessions:
    • Q8NG37
    • Q96JG7
    • Q96SQ2
    • Q9BYD8

    Protein attributes for MARK4 Gene

    Size:
    752 amino acids
    Molecular mass:
    82520 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with gamma-tubulin (PubMed:14594945). Interacts with ODF2 (PubMed:23400999). Interacts with USP9X (PubMed:18254724).
    SequenceCaution:
    • Sequence=BAB47489.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55238.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MARK4 Gene

    Alternative splice isoforms for MARK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARK4 Gene

Proteomics data for MARK4 Gene at MOPED

Post-translational modifications for MARK4 Gene

  • Phosphorylated at Thr-214 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39 (PubMed:14976552). Phosphorylated throughout the cell cycle (PubMed:25123532).
  • Ubiquitinated with Lys-29- and Lys-33-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation. Deubiquitinated by USP9X.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MARK4 (MARK4)
  • Abcam antibodies for MARK4

Domains & Families for MARK4 Gene

Gene Families for MARK4 Gene

Suggested Antigen Peptide Sequences for MARK4 Gene

Graphical View of Domain Structure for InterPro Entry

Q96L34

UniProtKB/Swiss-Prot:

MARK4_HUMAN :
  • Contains 1 KA1 (kinase-associated) domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Domain:
  • Contains 1 KA1 (kinase-associated) domain.
  • Contains 1 protein kinase domain.
  • Contains 1 UBA domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with MARK4: view

Function for MARK4 Gene

Molecular function for MARK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-214.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942).

Enzyme Numbers (IUBMB) for MARK4 Gene

Gene Ontology (GO) - Molecular Function for MARK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043015 gamma-tubulin binding IDA 14594945
GO:0043130 ubiquitin binding NAS 14594945
genes like me logo Genes that share ontologies with MARK4: view
genes like me logo Genes that share phenotypes with MARK4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MARK4

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MARK4 Gene

Localization for MARK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARK4 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm. Note=Localized at the tips of neurite-like processes in differentiated neuroblast cells. Detected in the cytoplasm and neuropil of the hippocampus. {ECO:0000269 PubMed:14594945, ECO:0000269 PubMed:23666762}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MARK4 Gene COMPARTMENTS Subcellular localization image for MARK4 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3

Gene Ontology (GO) - Cellular Components for MARK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005815 microtubule organizing center IDA 14594945
genes like me logo Genes that share ontologies with MARK4: view

Pathways & Interactions for MARK4 Gene

genes like me logo Genes that share pathways with MARK4: view

Pathways by source for MARK4 Gene

1 Cell Signaling Technology pathway for MARK4 Gene
1 BioSystems pathway for MARK4 Gene

SIGNOR curated interactions for MARK4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MARK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle NAS --
GO:0001578 microtubule bundle formation IEP 14594945
GO:0006996 organelle organization TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0008284 positive regulation of cell proliferation IDA --
genes like me logo Genes that share ontologies with MARK4: view

Drugs & Compounds for MARK4 Gene

(1) Drugs for MARK4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for MARK4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MARK4: view

Transcripts for MARK4 Gene

Unigene Clusters for MARK4 Gene

MAP/microtubule affinity-regulating kinase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MARK4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^
SP1: -
SP2:
SP3: -
SP4: - - - - - - - - - - - - - - - - - - -
SP5:
SP6: -
SP7: - -
SP8:

ExUns: 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for MARK4 Gene

GeneLoc Exon Structure for
MARK4
ECgene alternative splicing isoforms for
MARK4

Expression for MARK4 Gene

mRNA expression in normal human tissues for MARK4 Gene

Protein differential expression in normal tissues from HIPED for MARK4 Gene

This gene is overexpressed in Fetal Brain (19.4), Frontal cortex (14.2), Testis (12.6), Retina (11.5), and Brain (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MARK4 Gene



SOURCE GeneReport for Unigene cluster for MARK4 Gene Hs.34314

mRNA Expression by UniProt/SwissProt for MARK4 Gene

Q96L34-MARK4_HUMAN
Tissue specificity: Ubiquitous. Isoform 2 is brain-specific (PubMed:11326310). Expressed at highest levels in brain and testis. Also expressed in heart, lung, liver, muscle, kidney and spleen (PubMed:14594945).
genes like me logo Genes that share expression patterns with MARK4: view

Protein tissue co-expression partners for MARK4 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MARK4 Gene

Orthologs for MARK4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MARK4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MARK4 35
  • 95.37 (n)
  • 98.86 (a)
MARK4 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MARK4 35
  • 94.02 (n)
  • 98.37 (a)
MARK4 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mark4 35
  • 90.87 (n)
  • 97.61 (a)
Mark4 16
Mark4 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MARK4 35
  • 99.51 (n)
  • 99.87 (a)
MARK4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mark4 35
  • 90.82 (n)
  • 97.74 (a)
lizard
(Anolis carolinensis)
Reptilia MARK4 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mark4 35
  • 66.34 (n)
  • 73.74 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-31m14.7 35
  • 71.28 (n)
  • 74.76 (a)
MARK4 (2 of 2) 36
  • 72 (a)
OneToMany
mark4a 36
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG15072 37
  • 47 (a)
CG3105 37
  • 30 (a)
KP78a 37
  • 61 (a)
KP78b 37
  • 63 (a)
par-1 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0511.4 37
  • 37 (a)
DC2.7a 37
  • 31 (a)
DC2.7b 37
  • 31 (a)
F23C8.8 37
  • 28 (a)
kin-29 37
  • 42 (a)
R02C2.1 37
  • 33 (a)
W02B12.12 37
  • 32 (a)
par-1 36
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
corn
(Zea mays)
Liliopsida Zm.13822 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for MARK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARK4 Gene

ENSEMBL:
Gene Tree for MARK4 (if available)
TreeFam:
Gene Tree for MARK4 (if available)

Paralogs for MARK4 Gene

Pseudogenes.org Pseudogenes for MARK4 Gene

genes like me logo Genes that share paralogs with MARK4: view

Variants for MARK4 Gene

Sequence variations from dbSNP and Humsavar for MARK4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs35070611 - 45,280,588(+) GGACC(A/C/G)GGGCG reference, missense
VAR_040767 A colorectal adenocarcinoma sample
rs7256294 -- 45,272,158(+) gagac(A/G)ctgtc intron-variant
rs12976518 -- 45,256,086(+) CAACA(A/G)TGTTT intron-variant
rs12977525 -- 45,257,675(+) acctc(A/G)cctgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARK4 Gene

Variant ID Type Subtype PubMed ID
nsv833843 CNV Loss 17160897
nsv912143 CNV Loss 21882294
esv2422482 CNV Duplication 17116639
nsv833844 CNV Loss 17160897
nsv912145 CNV Loss 21882294
nsv912146 CNV Loss 21882294

Variation tolerance for MARK4 Gene

Residual Variation Intolerance Score: 7.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MARK4 Gene

Human Gene Mutation Database (HGMD)
MARK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARK4 Gene

Disorders for MARK4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MARK4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
insomnia, fatal familial
  • fatal familial insomnia
peutz-jeghers syndrome
  • colonic hamartomatous polyp
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards
Search MARK4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MARK4

Genetic Association Database (GAD)
MARK4
Human Genome Epidemiology (HuGE) Navigator
MARK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MARK4
genes like me logo Genes that share disorders with MARK4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARK4 Gene

Publications for MARK4 Gene

  1. Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis. (PMID: 11326310) Kato T. … Furukawa Y. (Neoplasia 2001) 2 3 4 23 67
  2. The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis. (PMID: 23400999) Kuhns S. … Pereira G. (J. Cell Biol. 2013) 2 3
  3. Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. (PMID: 14676191) Brajenovic M. … Drewes G. (J. Biol. Chem. 2004) 3 23
  4. The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines. (PMID: 12735302) Beghini A. … Larizza L. (Oncogene 2003) 3 23
  5. MARK - a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. (PMID: 9108484) Drewes G. … Mandelkow E. (Cell 1997) 2 3

Products for MARK4 Gene

Sources for MARK4 Gene

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