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Aliases for MARK4 Gene

Aliases for MARK4 Gene

  • Microtubule Affinity Regulating Kinase 4 2 3 5
  • MAP/Microtubule Affinity-Regulating Kinase Like 1 2 3
  • MAP/Microtubule Affinity-Regulating Kinase 4 2 3
  • EC 2.7.11.1 4 61
  • MARKL1 3 4
  • MAP/Microtubule Affinity-Regulating Kinase-Like 1 4
  • MARK4 Serine/Threonine Protein Kinase 3
  • EC 2.7.11 61
  • KIAA1860 4
  • MARKL1L 3
  • MARK4L 3
  • MARK4S 3
  • PAR-1D 3

External Ids for MARK4 Gene

Previous HGNC Symbols for MARK4 Gene

  • MARKL1

Previous GeneCards Identifiers for MARK4 Gene

  • GC19P046399
  • GC19P046145
  • GC19P050430
  • GC19P050446
  • GC19P045754
  • GC19P042186
  • GC19P045583

Summaries for MARK4 Gene

Entrez Gene Summary for MARK4 Gene

  • This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for MARK4 Gene

MARK4 (Microtubule Affinity Regulating Kinase 4) is a Protein Coding gene. Diseases associated with MARK4 include Insomnia, Fatal Familial and Alzheimer Disease. Among its related pathways are LKB1 signaling events and Organelle biogenesis and maintenance. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MARK3.

UniProtKB/Swiss-Prot for MARK4 Gene

  • Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942).

Gene Wiki entry for MARK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARK4 Gene

Genomics for MARK4 Gene

Regulatory Elements for MARK4 Gene

Enhancers for MARK4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F045306 0.6 ENCODE 51.6 +227.6 227589 1.7 HDGF PKNOX1 ARNT NFRKB ZEB1 ZNF121 SCRT2 FOS EGR2 CEBPB MARK4 EXOC3L2 CD3EAP PPP1R13L CLASRP RELB GC19M045307 ENSG00000283632
GH19F045283 1.1 Ensembl ENCODE 45.4 +204.5 204514 1.2 BCOR CBX3 ZNF146 ZMYM3 BACH1 ZNF140 BCL11B RELA ZNF316 POLR2A MARK4 ZNF180 CCDC61 QPCTL MRPS15P2 ENSG00000267395 ENSG00000269148 GC19M045307 ENSG00000283632
GH19F045250 1.4 FANTOM5 ENCODE 20.6 +172.8 172847 2.9 HDGF YBX1 ZNF48 GLIS2 ZNF143 KLF7 SP3 ZNF610 SMARCA4 GLIS1 MARK4 RELB VASP CLASRP ENSG00000283632 GC19M045307
GH19F045244 0.8 Ensembl ENCODE 20 +166.2 166187 1.2 HDAC1 TBL1XR1 ZNF48 SCRT2 CREM KLF13 SP5 NR2F2 KLF16 SMARCA4 MARK4 ENSG00000283632 GC19M045307
GH19F045307 0.4 ENCODE 16.5 +228.8 228790 0.5 BCOR KLF1 ZBTB40 GTF3C2 FOXK2 POLR2A ADNP TRIM24 ZBTB10 SMARCA5 ZNF180 MARK4 FBXO46 CCDC61 ENSG00000269148 ENSG00000266958 EXOC3L2 CD3EAP PPP1R13L CLASRP
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MARK4 on UCSC Golden Path with GeneCards custom track

Promoters for MARK4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000044730 312 1601 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 SLC30A9 ZNF143

Genomic Location for MARK4 Gene

Chromosome:
19
Start:
45,079,288 bp from pter
End:
45,305,283 bp from pter
Size:
225,996 bases
Orientation:
Plus strand

Genomic View for MARK4 Gene

Genes around MARK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARK4 Gene

Proteins for MARK4 Gene

  • Protein details for MARK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L34-MARK4_HUMAN
    Recommended name:
    MAP/microtubule affinity-regulating kinase 4
    Protein Accession:
    Q96L34
    Secondary Accessions:
    • Q8NG37
    • Q96JG7
    • Q96SQ2
    • Q9BYD8

    Protein attributes for MARK4 Gene

    Size:
    752 amino acids
    Molecular mass:
    82520 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with gamma-tubulin (PubMed:14594945). Interacts with ODF2 (PubMed:23400999). Interacts with USP9X (PubMed:18254724).
    SequenceCaution:
    • Sequence=BAB47489.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55238.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MARK4 Gene

    Alternative splice isoforms for MARK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARK4 Gene

Selected DME Specific Peptides for MARK4 Gene

Q96L34:
  • SLQKLFREVRIMK
  • EVDIWSLG
  • LTGREVA
  • TIGKGNFA
  • GARCRNSIASC
  • KIIDKTQL
  • RRNTYVC
  • FRQIVSA
  • FAKVKLA
  • GPEVDIWS
  • WSLGVILY
  • RQIVSAV
  • NLKELRERVLRGKYR
  • VAIKIID
  • GEVFDYLV
  • DFGFSNEFT
  • WSLGVILYTLVSGSLPFDG
  • LNHPNIVKLFEVIETEKTLYL
  • GSPPYAAPE
  • NHPNIVKL
  • IVHRDLK

Post-translational modifications for MARK4 Gene

  • Phosphorylated at Thr-214 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39 (PubMed:14976552). Phosphorylated throughout the cell cycle (PubMed:25123532).
  • Ubiquitinated with Lys-29- and Lys-33-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation. Deubiquitinated by USP9X.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MARK4 Gene

Gene Families for MARK4 Gene

Suggested Antigen Peptide Sequences for MARK4 Gene

Graphical View of Domain Structure for InterPro Entry

Q96L34

UniProtKB/Swiss-Prot:

MARK4_HUMAN :
  • Contains 1 KA1 (kinase-associated) domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Domain:
  • Contains 1 KA1 (kinase-associated) domain.
  • Contains 1 protein kinase domain.
  • Contains 1 UBA domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with MARK4: view

Function for MARK4 Gene

Molecular function for MARK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-214.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942).

Enzyme Numbers (IUBMB) for MARK4 Gene

Gene Ontology (GO) - Molecular Function for MARK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA,NAS 15009667
GO:0005515 protein binding IPI 14594945
GO:0005524 ATP binding IEA,NAS 15009667
genes like me logo Genes that share ontologies with MARK4: view
genes like me logo Genes that share phenotypes with MARK4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MARK4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MARK4 Gene

Localization for MARK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARK4 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm. Note=Localized at the tips of neurite-like processes in differentiated neuroblast cells. Detected in the cytoplasm and neuropil of the hippocampus. {ECO:0000269 PubMed:14594945, ECO:0000269 PubMed:23666762}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MARK4 Gene COMPARTMENTS Subcellular localization image for MARK4 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3

Gene Ontology (GO) - Cellular Components for MARK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000930 gamma-tubulin complex IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 14594945
GO:0005815 microtubule organizing center IDA 14594945
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MARK4: view

Pathways & Interactions for MARK4 Gene

genes like me logo Genes that share pathways with MARK4: view

Pathways by source for MARK4 Gene

1 Cell Signaling Technology pathway for MARK4 Gene
1 BioSystems pathway for MARK4 Gene

SIGNOR curated interactions for MARK4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MARK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle NAS --
GO:0000226 microtubule cytoskeleton organization IEA,IMP 14594945
GO:0001578 microtubule bundle formation IEP 14594945
GO:0006468 protein phosphorylation NAS,TAS 14594945
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with MARK4: view

Drugs & Compounds for MARK4 Gene

(1) Drugs for MARK4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for MARK4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MARK4: view

Transcripts for MARK4 Gene

Unigene Clusters for MARK4 Gene

MAP/microtubule affinity-regulating kinase 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARK4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^
SP1: -
SP2:
SP3: -
SP4: - - - - - - - - - - - - - - - - - - -
SP5:
SP6: -
SP7: - -
SP8:

ExUns: 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for MARK4 Gene

GeneLoc Exon Structure for
MARK4
ECgene alternative splicing isoforms for
MARK4

Expression for MARK4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MARK4 Gene

Protein differential expression in normal tissues from HIPED for MARK4 Gene

This gene is overexpressed in Fetal Brain (19.4), Frontal cortex (14.2), Testis (12.6), Retina (11.5), and Brain (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MARK4 Gene



Protein tissue co-expression partners for MARK4 Gene

NURSA nuclear receptor signaling pathways regulating expression of MARK4 Gene:

MARK4

SOURCE GeneReport for Unigene cluster for MARK4 Gene:

Hs.34314

mRNA Expression by UniProt/SwissProt for MARK4 Gene:

Q96L34-MARK4_HUMAN
Tissue specificity: Ubiquitous. Isoform 2 is brain-specific (PubMed:11326310). Expressed at highest levels in brain and testis. Also expressed in heart, lung, liver, muscle, kidney and spleen (PubMed:14594945).
genes like me logo Genes that share expression patterns with MARK4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MARK4 Gene

Orthologs for MARK4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MARK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARK4 34 35
  • 99.51 (n)
cow
(Bos Taurus)
Mammalia MARK4 34 35
  • 95.37 (n)
dog
(Canis familiaris)
Mammalia MARK4 34 35
  • 94.02 (n)
mouse
(Mus musculus)
Mammalia Mark4 34 16 35
  • 90.87 (n)
rat
(Rattus norvegicus)
Mammalia Mark4 34
  • 90.82 (n)
lizard
(Anolis carolinensis)
Reptilia MARK4 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mark4 34
  • 66.34 (n)
zebrafish
(Danio rerio)
Actinopterygii MARK4 (2 of 2) 35
  • 72 (a)
OneToMany
si:dkey-31m14.7 34
  • 71.28 (n)
mark4a 35
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta KP78b 36
  • 63 (a)
KP78a 36
  • 61 (a)
CG15072 36
  • 47 (a)
par-1 35
  • 31 (a)
OneToMany
CG3105 36
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea kin-29 36
  • 42 (a)
B0511.4 36
  • 37 (a)
R02C2.1 36
  • 33 (a)
W02B12.12 36
  • 32 (a)
DC2.7a 36
  • 31 (a)
DC2.7b 36
  • 31 (a)
par-1 35
  • 29 (a)
OneToMany
F23C8.8 36
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
corn
(Zea mays)
Liliopsida Zm.13822 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
OneToMany
Species where no ortholog for MARK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARK4 Gene

ENSEMBL:
Gene Tree for MARK4 (if available)
TreeFam:
Gene Tree for MARK4 (if available)

Paralogs for MARK4 Gene

Paralogs for MARK4 Gene

genes like me logo Genes that share paralogs with MARK4: view

Variants for MARK4 Gene

Sequence variations from dbSNP and Humsavar for MARK4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs780763668 A colorectal adenocarcinoma sample 45,280,710(+) ACCAC(A/C/T)GCCAG reference, missense
rs10401753 -- 45,281,935(+) AGTCT(A/G)AGTTT intron-variant
rs10401954 -- 45,282,028(+) agacc(A/G)gcctg intron-variant
rs10404239 -- 45,285,791(+) TGAGC(A/G)TGTAT intron-variant
rs10405439 -- 45,255,936(+) GCTCA(A/G)AGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARK4 Gene

Variant ID Type Subtype PubMed ID
esv2422482 CNV duplication 17116639
nsv1071537 CNV deletion 25765185
nsv1111175 CNV tandem duplication 24896259
nsv1116335 CNV deletion 24896259
nsv1123262 CNV deletion 24896259
nsv474182 CNV novel sequence insertion 20440878
nsv833843 CNV loss 17160897
nsv833844 CNV loss 17160897

Variation tolerance for MARK4 Gene

Residual Variation Intolerance Score: 7.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MARK4 Gene

Human Gene Mutation Database (HGMD)
MARK4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MARK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARK4 Gene

Disorders for MARK4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MARK4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
insomnia, fatal familial
  • fatal familial insomnia
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards
Search MARK4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MARK4

Genetic Association Database (GAD)
MARK4
Human Genome Epidemiology (HuGE) Navigator
MARK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MARK4
genes like me logo Genes that share disorders with MARK4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARK4 Gene

Publications for MARK4 Gene

  1. Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis. (PMID: 11326310) Kato T. … Furukawa Y. (Neoplasia 2001) 2 3 4 22 64
  2. The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis. (PMID: 23400999) Kuhns S. … Pereira G. (J. Cell Biol. 2013) 2 3 4 64
  3. Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) plays a role in cell cycle progression and cytoskeletal dynamics. (PMID: 25123532) Rovina D. … Larizza L. (Eur. J. Cell Biol. 2014) 3 4 64
  4. Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of rapamycin complex 1 (mTORC1). (PMID: 23184942) Li L. … Guan K.L. (J. Biol. Chem. 2013) 3 4 64
  5. Role of individual MARK isoforms in phosphorylation of tau at SerA^a8PA^ in Alzheimer's disease. (PMID: 23666762) Gu G.J. … Kamali-Moghaddam M. (Neuromolecular Med. 2013) 3 4 64

Products for MARK4 Gene

Sources for MARK4 Gene

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