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Aliases for MARK4 Gene

Aliases for MARK4 Gene

  • MAP/Microtubule Affinity-Regulating Kinase 4 2 3
  • MAP/Microtubule Affinity-Regulating Kinase Like 1 2 3
  • EC 4 63
  • MARKL1 3 4
  • MAP/Microtubule Affinity-Regulating Kinase-Like 1 4
  • MARK4 Serine/Threonine Protein Kinase 3
  • EC 2.7.11 63
  • KIAA1860 4
  • MARKL1L 3
  • MARK4L 3
  • MARK4S 3
  • PAR-1D 3

External Ids for MARK4 Gene

Previous HGNC Symbols for MARK4 Gene

  • MARKL1

Previous GeneCards Identifiers for MARK4 Gene

  • GC19P046399
  • GC19P046145
  • GC19P050430
  • GC19P050446
  • GC19P045754
  • GC19P042186
  • GC19P045583

Summaries for MARK4 Gene

Entrez Gene Summary for MARK4 Gene

  • This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for MARK4 Gene

MARK4 (MAP/Microtubule Affinity-Regulating Kinase 4) is a Protein Coding gene. Diseases associated with MARK4 include alzheimer disease. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MARK3.

Gene Wiki entry for MARK4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARK4 Gene

Genomics for MARK4 Gene

Regulatory Elements for MARK4 Gene

Genomic Location for MARK4 Gene

45,079,288 bp from pter
45,305,283 bp from pter
225,996 bases
Plus strand

Genomic View for MARK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARK4 Gene

Proteins for MARK4 Gene

  • Protein details for MARK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MAP/microtubule affinity-regulating kinase 4
    Protein Accession:
    Secondary Accessions:
    • Q8NG37
    • Q96JG7
    • Q96SQ2
    • Q9BYD8

    Protein attributes for MARK4 Gene

    752 amino acids
    Molecular mass:
    82520 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB47489.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55238.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MARK4 Gene


neXtProt entry for MARK4 Gene

Proteomics data for MARK4 Gene at MOPED

Post-translational modifications for MARK4 Gene

  • Phosphorylated at Thr-214 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
  • Ubiquitinated with Lys-29- and Lys-33-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation. Deubiquitinated by USP9X.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MARK4 (MARK4)

Domains & Families for MARK4 Gene

Gene Families for MARK4 Gene

Suggested Antigen Peptide Sequences for MARK4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KA1 (kinase-associated) domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
  • Contains 1 KA1 (kinase-associated) domain.
  • Contains 1 protein kinase domain.
  • Contains 1 UBA domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with MARK4: view

Function for MARK4 Gene

Molecular function for MARK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-214.

Enzyme Numbers (IUBMB) for MARK4 Gene

Gene Ontology (GO) - Molecular Function for MARK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 15009667
GO:0005515 protein binding IPI 14594945
GO:0005524 ATP binding NAS 15009667
GO:0008017 microtubule binding IDA 14594945
genes like me logo Genes that share ontologies with MARK4: view
genes like me logo Genes that share phenotypes with MARK4: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MARK4

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for MARK4 Gene

Localization for MARK4 Gene

Subcellular locations from

Jensen Localization Image for MARK4 Gene COMPARTMENTS Subcellular localization image for MARK4 gene
Compartment Confidence
cytoskeleton 5
cytosol 4

Gene Ontology (GO) - Cellular Components for MARK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000930 gamma-tubulin complex --
GO:0005737 cytoplasm --
GO:0005813 centrosome IDA 14594945
GO:0005815 microtubule organizing center IDA 14594945
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MARK4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MARK4 Gene

Pathways & Interactions for MARK4 Gene

genes like me logo Genes that share pathways with MARK4: view

Pathways by source for MARK4 Gene

1 Cell Signaling Technology pathway for MARK4 Gene
1 BioSystems pathway for MARK4 Gene

SIGNOR curated interactions for MARK4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MARK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle --
GO:0000086 G2/M transition of mitotic cell cycle --
GO:0000226 microtubule cytoskeleton organization IMP 14594945
GO:0001578 microtubule bundle formation IEP 14594945
GO:0006468 protein phosphorylation TAS 14594945
genes like me logo Genes that share ontologies with MARK4: view

Drugs & Compounds for MARK4 Gene

(1) Drugs for MARK4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for MARK4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with MARK4: view

Transcripts for MARK4 Gene

Unigene Clusters for MARK4 Gene

MAP/microtubule affinity-regulating kinase 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MARK4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARK4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^
SP1: -
SP3: -
SP4: - - - - - - - - - - - - - - - - - - -
SP6: -
SP7: - -

ExUns: 19a · 19b

Relevant External Links for MARK4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MARK4 Gene

mRNA expression in normal human tissues for MARK4 Gene

Protein differential expression in normal tissues from HIPED for MARK4 Gene

This gene is overexpressed in Fetal Brain (19.4), Frontal cortex (14.2), Testis (12.6), Retina (11.5), and Brain (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MARK4 Gene

SOURCE GeneReport for Unigene cluster for MARK4 Gene Hs.34314

mRNA Expression by UniProt/SwissProt for MARK4 Gene

Tissue specificity: Ubiquitous. Isoform 2 is brain-specific.
genes like me logo Genes that share expression patterns with MARK4: view

Protein tissue co-expression partners for MARK4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MARK4 Gene

Orthologs for MARK4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MARK4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MARK4 35
  • 95.37 (n)
  • 98.86 (a)
MARK4 36
  • 96 (a)
(Canis familiaris)
Mammalia MARK4 35
  • 94.02 (n)
  • 98.37 (a)
MARK4 36
  • 97 (a)
(Mus musculus)
Mammalia Mark4 35
  • 90.87 (n)
  • 97.61 (a)
Mark4 16
Mark4 36
  • 98 (a)
(Pan troglodytes)
Mammalia MARK4 35
  • 99.51 (n)
  • 99.87 (a)
MARK4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mark4 35
  • 90.82 (n)
  • 97.74 (a)
(Anolis carolinensis)
Reptilia MARK4 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mark4 35
  • 66.34 (n)
  • 73.74 (a)
(Danio rerio)
Actinopterygii si:dkey-31m14.7 35
  • 71.28 (n)
  • 74.76 (a)
MARK4 (2 of 2) 36
  • 72 (a)
mark4a 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15072 37
  • 47 (a)
CG3105 37
  • 30 (a)
KP78a 37
  • 61 (a)
KP78b 37
  • 63 (a)
par-1 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea B0511.4 37
  • 37 (a)
DC2.7a 37
  • 31 (a)
DC2.7b 37
  • 31 (a)
F23C8.8 37
  • 28 (a)
kin-29 37
  • 42 (a)
R02C2.1 37
  • 33 (a)
W02B12.12 37
  • 32 (a)
par-1 36
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
(Zea mays)
Liliopsida Zm.13822 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for MARK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARK4 Gene

Gene Tree for MARK4 (if available)
Gene Tree for MARK4 (if available)

Paralogs for MARK4 Gene

Paralogs for MARK4 Gene Pseudogenes for MARK4 Gene

genes like me logo Genes that share paralogs with MARK4: view

Variants for MARK4 Gene

Sequence variations from dbSNP and Humsavar for MARK4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1568 -- 45,294,834(+) GGGAG(A/G)GAAAC intron-variant
rs2395 -- 45,303,351(+) ATTTA(A/G)GAGAG utr-variant-3-prime
rs173179 -- 45,297,760(+) GCACG(C/T)GGTTC reference, synonymous-codon
rs180779 -- 45,255,268(+) CAAGT(C/T)TGGTG intron-variant
rs184688 -- 45,255,106(+) ctgag(A/C/G/T)tggga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARK4 Gene

Variant ID Type Subtype PubMed ID
nsv833843 CNV Loss 17160897
nsv912143 CNV Loss 21882294
esv2422482 CNV Duplication 17116639
nsv833844 CNV Loss 17160897
nsv912145 CNV Loss 21882294
nsv912146 CNV Loss 21882294

Variation tolerance for MARK4 Gene

Residual Variation Intolerance Score: 7.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MARK4 Gene

HapMap Linkage Disequilibrium report

PCR Panel Products

  • Copy Number PCR Panels: for MARK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARK4 Gene

Disorders for MARK4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MARK4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • alzheimer disease, late-onset
- elite association
Search MARK4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MARK4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MARK4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARK4 Gene

Publications for MARK4 Gene

  1. Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis. (PMID: 11326310) Kato T. … Furukawa Y. (Neoplasia 2001) 2 23 67
  2. The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis. (PMID: 23400999) Kuhns S. … Pereira G. (J. Cell Biol. 2013) 2 67
  3. Distinct expression pattern of microtubule-associated protein/microtubule affinity-regulating kinase 4 in differentiated neurons. (PMID: 16973293) Moroni R.F. … Beghini A. (Neuroscience 2006) 23 67
  4. Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. (PMID: 14676191) Brajenovic M. … Drewes G. (J. Biol. Chem. 2004) 23 67
  5. The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines. (PMID: 12735302) Beghini A. … Larizza L. (Oncogene 2003) 23 67

Products for MARK4 Gene

Sources for MARK4 Gene

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