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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MARK3 Gene

protein-coding   GIFtS: 64
GCID: GC14P103851

MAP/Microtubule Affinity-Regulating Kinase 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MAP/Microtubule Affinity-Regulating Kinase 31 2     Par-1a2 3
Cdc25C-Associated Protein Kinase 12 3     ELKL Motif Kinase 22 3
Protein Kinase STK102 3     EC 2.7.11.13 8
Ser/Thr Protein Kinase PAR-12 3     KP782
Serine/Threonine-Protein Kinase P782 3     PAR1A2
C-TAK12 3     EMK23
CTAK12 3     cTAK13
EMK-22 3     EC 2.7.118

External Ids:    HGNC: 68971   Entrez Gene: 41402   Ensembl: ENSG000000754137   OMIM: 6026785   UniProtKB: P274483   

Export aliases for MARK3 gene to outside databases

Previous GC identifers: GC14P101243 GC14P097667 GC14P101841 GC14P102921 GC14P084029


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MARK3 Gene:
The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of
tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for MARK3 Gene: 
MARK3 (MAP/microtubule affinity-regulating kinase 3) is a protein-coding gene. Diseases associated with MARK3 include peutz-jeghers syndrome, and cerebral palsy, and among its related super-pathways are Cytoskeleton remodeling Neurofilaments. GO annotations related to this gene include protein serine/threonine kinase activity and ATP binding. An important paralog of this gene is NUAK1.

UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448
Function: Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4.
Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating
phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus

Gene Wiki entry for MARK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MARK3 gene promoter:
         NF-YB   CBF-B   CBF-A   NF-YA   NF-YC   CP1C   CP1A   NF-Y   CBF-C   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MARK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MARK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.3   Ensembl cytogenetic band:  14q32.32   HGNC cytogenetic band: 14q32.3

MARK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARK3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P103851:  view genomic region     (about GC identifiers)

Start:
103,851,701 bp from pter      End:
103,970,168 bp from pter
Size:
118,468 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448 (See protein sequence)
Recommended Name: MAP/microtubule affinity-regulating kinase 3  
Size: 753 amino acids; 84489 Da
Subcellular location: Cell membrane; Peripheral membrane protein
2 PDB 3D structures from and Proteopedia for MARK3:
2QNJ (3D)        3FE3 (3D)    
Secondary accessions: O60219 Q86TT8 Q8TB41 Q8WX83 Q96RG1 Q9UMY9 Q9UN34
Alternative splicing: 7 isoforms:  P27448-5   P27448-2   P27448-3   P27448-4   P27448-6   P27448-7   P27448-8   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MARK3: NX_P27448

Explore proteomics data for MARK3 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and
    CAB39. Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P27448

  • 4/27 DME Specific Peptides for MARK3 (P27448) (see all 27)
     FAKVKLA  EYASGGE  LVAHGRM  LTGREVA 

    MARK3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MARK3 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001122390.1  NP_001122391.1  NP_001122392.1  NP_001122393.1  NP_002367.4  

    ENSEMBL proteins: 
     ENSP00000402104   ENSP00000408092   ENSP00000411397   ENSP00000303698   ENSP00000216288  
     ENSP00000450772   ENSP00000454169   ENSP00000335347   ENSP00000452829   ENSP00000450460  
     ENSP00000452893   ENSP00000451623  

    Human Recombinant Protein Products for MARK3: 
    EMD Millipore Purified and/or Recombinant MARK3 Protein
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    OriGene Protein Over-expression Lysate for MARK3
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    Novus Biologicals MARK3 Proteins
    Novus Biologicals MARK3 Lysates
    Sino Biological Recombinant Protein for MARK3
    Sino Biological Cell Lysate for MARK3 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MARK3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--

    MARK3 for ontologies           About GeneDecksing



    MARK3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MARK3
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    Abcam antibodies for MARK3
    Cloud-Clone Corp. Antibodies for MARK3 
    ThermoFisher Antibody for MARK3
    LSBio Antibodies in human, mouse, rat for MARK3 

    Assay Products for MARK3: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MARK3 
    Cloud-Clone Corp. CLIAs for MARK3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: MAP/microtubule affinity-regulating kinase 3 
    MARK subfamily

    5/7 InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR001772 KA1_dom
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry P27448

    ProtoNet protein and cluster: P27448

    2 Blocks protein domains:
    IPB000449 Ubiquitin-associated domain
    IPB001772 Kinase-associated


    UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily
    Similarity: Contains 1 KA1 (kinase-associated) domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UBA domain


    MARK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARK3_HUMAN, P27448
    Function: Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4.
    Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating
    phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-211. Inhibited by phosphorylation on Thr-564

         Genatlas biochemistry entry for MARK3:
    MAP/microtubule affinity-regulating kinase 3 deleted in pancreas carcinoma

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA16980613
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI12556533
    GO:0005524ATP binding IEA--
         
    MARK3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MARK3:
     Decreased substrate adherent c  Increased cell death HMECs cel 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mark3):
     adipose tissue  growth/size  homeostasis/metabolism  liver/biliary system  mortality/aging 
     no phenotypic analysis 

    MARK3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mark3tm1Hpw for MARK3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MARK3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MARK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARK3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARK3 

    miRNA
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    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate MARK3 (see all 20):
    hsa-miR-142-3p hsa-miR-3607-3p hsa-miR-137 hsa-miR-29a hsa-miR-29c hsa-miR-16-1* hsa-miR-301a hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidMARK3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARK3

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    Sino Biological Human cDNA Clone for MARK3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARK3
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                         Customized lentivirus expression plasmids for stable overexpression of MARK3 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARK3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MARK3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytoskeleton remodeling Neurofilaments
    Cytoplasmic microtubules0.32
    2Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    3Cytoskeletal Signaling
    Cytoskeletal Signaling
    4TGF-beta Signaling Pathway
    TGF-beta Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MARK3
        Cytoplasmic microtubules


    2 Cell Signaling Technology (CST) Pathways for MARK3
        Wnt / Hedgehog / Notch
    Cytoskeletal Signaling

    1 Sino Biological Pathway for MARK3 
        TGF-beta Signaling Pathway



    MARK3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MARK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/46 Interacting proteins for MARK3 (P274481, 2, 3 ENSP000004113974) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3, ENSP000003409894MINT-66900 MINT-3975719 I2D: score=5 STRING: ENSP00000340989
    PKP2Q999592, 3, ENSP000000708464MINT-16617 MINT-16618 I2D: score=2 STRING: ENSP00000070846
    PNPLA2Q96AD52, 3, ENSP000003377014MINT-63622 I2D: score=5 STRING: ENSP00000337701
    PRKCQQ047592, 3, ENSP000002631254MINT-4787821 I2D: score=3 STRING: ENSP00000263125
    PPM1BO756882, 3, ENSP000002824124MINT-8247539 I2D: score=1 STRING: ENSP00000282412
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    MARK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MARK3

    2 HMDB Compounds for MARK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about MARK3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MARK3 gene (5 alternative transcripts): 
    NM_001128918.1  NM_001128919.1  NM_001128920.1  NM_001128921.1  NM_002376.5  

    Unigene Cluster for MARK3:

    MAP/microtubule affinity-regulating kinase 3
    Hs.35828  [show with all ESTs]
    Unigene Representative Sequence: NM_001128918
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000440884 ENST00000559328 ENST00000560603 ENST00000416682 ENST00000429436(uc001ymz.4 uc001ymx.4 uc001ymw.4 uc001yna.4 uc001ymy.4 uc010awp.3 uc010tyb.2 uc010awq.3)
    ENST00000303622 ENST00000216288 ENST00000553942(uc021sef.1) ENST00000560417
    ENST00000558223 ENST00000335102 ENST00000561225 ENST00000561071 ENST00000558698
    ENST00000560731 ENST00000559268 ENST00000561164 ENST00000554627
    miRNA
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    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate MARK3 (see all 20):
    hsa-miR-142-3p hsa-miR-3607-3p hsa-miR-137 hsa-miR-29a hsa-miR-29c hsa-miR-16-1* hsa-miR-301a hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidMARK3 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARK3
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARK3

    Additional mRNA sequence: 

    AF170723.1 AF387637.1 AF465413.1 AK023963.1 AK055814.1 AK056714.1 AK124459.1 AK124796.1 
    AK296643.1 AK307448.1 BC024773.1 BX161395.1 BX248250.1 DQ368336.1 M80359.1 M83780.1 
    U64205.1 

    24/37 DOTS entries (see all 37):

    DT.86855293  DT.95264963  DT.100714279  DT.100698434  DT.100844722  DT.100844716  DT.100844721  DT.317922 
    DT.100673793  DT.120767212  DT.100029578  DT.100844711  DT.120767219  DT.120767148  DT.120767164  DT.95124116 
    DT.95264961  DT.97785685  DT.100844733  DT.100844732  DT.449218  DT.95264965  DT.100844734  DT.101979967 

    24/430 AceView cDNA sequences (see all 430):

    AF387637 BQ936331 BI823636 F02748 BX357829 BI087108 AU146630 BE792279 
    AW138470 CB529992 BG036631 BQ018304 BM988013 BE796014 BM910621 BM702885 
    AA642662 BX248250 BI850828 BX161395 AI890939 AW516180 NM_002376 BQ229423 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for MARK3 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
    SP1:                                                                                                              -     -                             -         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                              -                                   -         
    SP5:                                                        -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -         

    ExUns: 18 ^ 19a · 19b ^ 20a · 20b · 20c · 20d · 20e · 20f · 20g
    SP1:        -                                                   
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:  -     -     -                                             


    ECgene alternative splicing isoforms for MARK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MARK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGTGGTTT
    MARK3 Expression
    About this image


    See MARK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MARK3

    SOURCE GeneReport for Unigene cluster: Hs.35828

    UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for MARK3
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MARK3 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mark31 , 5 MAP/microtubule affinity-regulating kinase 31, 5 89.89(n)1
    96.84(a)1
      12 (61.05 cM)5
    171691  NM_022801.41  NP_073712.21 
     1115745105 
    chicken
    (Gallus gallus)
    Aves MARK31 MAP/microtubule affinity-regulating kinase 3 84.37(n)
    96.28(a)
      423480  XM_421385.3  XP_421385.2 
    lizard
    (Anolis carolinensis)
    Reptilia MARK36
    Uncharacterized protein
    84(a)
    1 ↔ 1
    GL343232.1(161320-244112)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.19672 Xenopus laevis Ser/Thr protein kinase PAR-1A mRNA, more 79.58(n)    AF509737.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC047179.12   -- 73.64(n)   334300  BC047179.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta KP78a3
    par-11
    protein amino acid phosphorylation
    protein kinase3
    C-TAK1-like1
    56(a)
    (best of 4)3
    55.76(n)1
    59.07(a)1
      86E43
    27688521  NM_206178.21  NP_995900.11 
    worm
    (Caenorhabditis elegans)
    Secernentea kin-293
    par-11
    serine/threonine-protein kinase3
    Protein PAR-11
    39(a)
    (best of 2)3
    51.5(n)1
    53.83(a)1
      X(2880113-2887689)3
    1799121  NM_001129495.11  NP_001122967.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SNF16
    AMP-activated serine/threonine protein kinase foun...
    26(a)
    1 → many
    IV(1412373-1414274)


    ENSEMBL Gene Tree for MARK3 (if available)
    TreeFam Gene Tree for MARK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MARK3 gene
    NUAK12  MARK12  PRKAA22  SNRK2  SIK32  SIK22  PRKAA12  NUAK22  
    MARK22  NIM12  SIK12  MARK42  
    18/102 SIMAP similar genes for MARK3 using alignment to 7 protein entries:     MARK3_HUMAN (see all proteins) (see all similar genes):
    DKFZp547M202    MARK4    BRSK2    BRSK1    MARK2    KIAA0999
    SIK3    MARK1    HUNK    NUAK2    PHKG2    Par1b
    CDK3    PDPK1    STK32A    Nbla00650    CDKL1    PRKD2

    MARK3 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for MARK3
    PGOHUM00000239434 PGOHUM00000237761 PGOHUM00000261899


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2643 SNPs in MARK3 are shown (see all 2643)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0407654
    ----see VAR_0407652 V A mis40--------
    rs356114271,2
    C--84037337(+) TTTTTT/-AAATT 5 -- int11Minor allele frequency- -:0.50NA 2
    rs360030651,2
    C--84038294(+) ATTACT/-TTTTT 5 -- int11Minor allele frequency- -:0.50NA 2
    rs616352751,2
    C--84045516(+) TGTGT-/GT/TA/
    TGTGTGTG
    ATGCA
    5 -- int10--------
    rs2006719831,2
    C--84050297(+) TTTTT-/TTTGTA
            
    TTTTT
    5 -- int10--------
    rs114340621,2
    C--84053776(+) TAAGTG/-GGAGT 5 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs589868761,2
    C--84057184(+) ATAGT-/CTGATCT
    GCAA
    /GA/TT
    TCTTC
    5 -- int11NA 2
    rs1408851301,2
    C--84057184(+) TAGTT-/GAT   
      CTGCAA
    CTTCA
    5 -- cds10--------
    rs1396721721,2
    C--84069692(+) ATTTA-/TTAT  
            
    TTATT
    5 -- int10--------
    rs3711718781,2
    C--84077529(+) TTTTC-/T/TTT 
            
    TTTTC
    10 -- int1 cds10--------

    HapMap Linkage Disequilibrium report for MARK3 (103851701 - 103970168 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MARK3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676094CNV Deletion23128226
    dgv1992n71CNV Loss21882294
    nsv85551CNV Loss16902084
    nsv85420CNV Loss16902084
    nsv832883CNV Loss17160897
    nsv9168CNV Loss18304495
    nsv902300CNV Loss21882294
    nsv525874CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602678    OMIM disorders: --

    5 diseases for MARK3:    About MalaCards
    peutz-jeghers syndrome    cerebral palsy    microphthalmia    cerebritis
    obesity


    MARK3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MARK3
    Human Genome Epidemiology (HuGE) Navigator: MARK3 (4 documents)

    Export disorders for MARK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MARK3 gene, integrated from 9 sources (see all 65):
    (articles sorted by number of sources associating them with MARK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. (PubMed id 16980613)1, 2, 9 Dequiedt F....Kettmann R. (2006)
    2. OPG and RANK polymorphisms are both associated with c ortical bone mineral density: findings from a metaanalysis of the Avon longitud inal study of parents and children and gothenburg osteoporosis and obesity dete rminants cohorts. (PubMed id 20534768)1, 4 Paternoster L....Tobias J.H. (2010)
    3. Analysis of recently identified osteoporosis suscepti bility genes in Han Chinese women. (PubMed id 20554715)1, 4 Liu J.M....Ning G. (2010)
    4. New sequence variants associated with bone mineral density. (PubMed id 19079262)1, 4 Styrkarsdottir U....Stefansson K. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. (PubMed id 11433294)1, 2 Sun T.-Q....Williams L.T. (2001)
    7. C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. (PubMed id 9543386)1, 2 Peng C.Y.... Piwnica-Worms H. (1998)
    8. Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization. (PubMed id 9533022)1, 3 Ono T....Okamoto T. (1997)
    9. Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. (PubMed id 12941695)1, 9 Muller J....Morrison D.K. (2003)
    10. C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. (PubMed id 11741534)1, 9 Muller J....Morrison D.K. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4140 HGNC: 6897 AceView: MARK3 Ensembl:ENSG00000075413 euGenes: HUgn4140
    ECgene: MARK3 H-InvDB: MARK3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MARK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MARK3 gene:
    Search GeneIP for patents involving MARK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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