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Aliases for MARK3 Gene

Aliases for MARK3 Gene

  • MAP/Microtubule Affinity-Regulating Kinase 3 2 3
  • Serine/Threonine-Protein Kinase P78 3 4
  • Cdc25C-Associated Protein Kinase 1 3 4
  • Ser/Thr Protein Kinase PAR-1 3 4
  • Protein Kinase STK10 3 4
  • ELKL Motif Kinase 2 3 4
  • EC 2.7.11.1 4 63
  • C-TAK1 3 4
  • Par-1a 3 4
  • CTAK1 3 4
  • EMK-2 3 4
  • EC 2.7.11 63
  • PAR1A 3
  • KP78 3
  • EMK2 4

External Ids for MARK3 Gene

Previous GeneCards Identifiers for MARK3 Gene

  • GC14P101243
  • GC14P097667
  • GC14P101841
  • GC14P102921
  • GC14P103851
  • GC14P084029

Summaries for MARK3 Gene

Entrez Gene Summary for MARK3 Gene

  • The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for MARK3 Gene

MARK3 (MAP/Microtubule Affinity-Regulating Kinase 3) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and TGF-beta Signaling Pathway (sino). GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is MARK4.

UniProtKB/Swiss-Prot for MARK3 Gene

  • Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on Ser-216. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.

Gene Wiki entry for MARK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARK3 Gene

Genomics for MARK3 Gene

Regulatory Elements for MARK3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MARK3 Gene

Start:
103,385,364 bp from pter
End:
103,503,831 bp from pter
Size:
118,468 bases
Orientation:
Plus strand

Genomic View for MARK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARK3 Gene

Proteins for MARK3 Gene

  • Protein details for MARK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27448-MARK3_HUMAN
    Recommended name:
    MAP/microtubule affinity-regulating kinase 3
    Protein Accession:
    P27448
    Secondary Accessions:
    • O60219
    • Q86TT8
    • Q8TB41
    • Q8WX83
    • Q96RG1
    • Q9UMY9
    • Q9UN34

    Protein attributes for MARK3 Gene

    Size:
    753 amino acids
    Molecular mass:
    84489 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MARK3 Gene

    Alternative splice isoforms for MARK3 Gene

neXtProt entry for MARK3 Gene

Proteomics data for MARK3 Gene at MOPED

Post-translational modifications for MARK3 Gene

  • Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity.
  • Ubiquitination at Lys317 and Lys740
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MARK3 (MARK3)

Domains for MARK3 Gene

Gene Families for MARK3 Gene

Suggested Antigen Peptide Sequences for MARK3 Gene

Graphical View of Domain Structure for InterPro Entry

P27448

UniProtKB/Swiss-Prot:

MARK3_HUMAN :
  • P27448
Domain:
  • Contains 1 KA1 (kinase-associated) domain.
  • Contains 1 protein kinase domain.
  • Contains 1 UBA domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with MARK3: view

Function for MARK3 Gene

Molecular function for MARK3 Gene

GENATLAS Biochemistry:
MAP/microtubule affinity-regulating kinase 3 deleted in pancreas carcinoma
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-211. Inhibited by phosphorylation on Thr-564.
UniProtKB/Swiss-Prot Function:
Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on Ser-216. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.

Enzyme Numbers (IUBMB) for MARK3 Gene

Gene Ontology (GO) - Molecular Function for MARK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 16980613
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 12556533
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MARK3: view
genes like me logo Genes that share phenotypes with MARK3: view

Animal Models for MARK3 Gene

MGI Knock Outs for MARK3:

Animal Model Products

miRNA for MARK3 Gene

miRTarBase miRNAs that target MARK3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MARK3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for MARK3 Gene

Localization for MARK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARK3 Gene

Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MARK3 Gene COMPARTMENTS Subcellular localization image for MARK3 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 3
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for MARK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 21145462
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with MARK3: view

Pathways for MARK3 Gene

genes like me logo Genes that share pathways with MARK3: view

Pathways by source for MARK3 Gene

1 Sino Biological pathway for MARK3 Gene
2 Cell Signaling Technology pathways for MARK3 Gene

Gene Ontology (GO) - Biological Process for MARK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation --
genes like me logo Genes that share ontologies with MARK3: view

Compounds for MARK3 Gene

(2) HMDB Compounds for MARK3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with MARK3: view

Transcripts for MARK3 Gene

Unigene Clusters for MARK3 Gene

MAP/microtubule affinity-regulating kinase 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MARK3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARK3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP1: - - -
SP2:
SP3:
SP4: - -
SP5: - - - - - - - - - - - - - - - -
SP6:
SP7: - -
SP8: -
SP9: -
SP10: - -
SP11: - -
SP12:
SP13:
SP14:

ExUns: 18 ^ 19a · 19b ^ 20a · 20b · 20c · 20d · 20e · 20f · 20g
SP1: -
SP2:
SP3:
SP4:
SP5: - - -
SP6:
SP7: - - -
SP8: - -
SP9:
SP10:
SP11: - - -
SP12: - - -
SP13:
SP14:

Relevant External Links for MARK3 Gene

GeneLoc Exon Structure for
MARK3
ECgene alternative splicing isoforms for
MARK3

Expression for MARK3 Gene

mRNA expression in normal human tissues for MARK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MARK3 Gene

This gene is overexpressed in Lung (59.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MARK3 Gene

SOURCE GeneReport for Unigene cluster for MARK3 Gene Hs.35828

mRNA Expression by UniProt/SwissProt for MARK3 Gene

P27448-MARK3_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with MARK3: view

Expression partners for MARK3 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MARK3 Gene

Orthologs for MARK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MARK3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MARK3 35
  • 92.11 (n)
  • 96.97 (a)
MARK3 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MARK3 35
  • 91.89 (n)
  • 97.04 (a)
MARK3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mark3 35
  • 90.05 (n)
  • 96.91 (a)
Mark3 16
Mark3 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MARK3 35
  • 99.55 (n)
  • 99.73 (a)
MARK3 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mark3 35
  • 88.53 (n)
  • 94.62 (a)
oppossum
(Monodelphis domestica)
Mammalia MARK3 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MARK3 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves MARK3 35
  • 83.96 (n)
  • 95.7 (a)
MARK3 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MARK3 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mark3 35
  • 80.5 (n)
  • 93.11 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1967 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
zgc:153725 35
  • 75.46 (n)
  • 87.55 (a)
mark3 36
  • 75 (a)
OneToMany
MARK3 (2 of 3) 36
  • 87 (a)
OneToMany
MARK3 (3 of 3) 36
  • 85 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG15072 37
  • 45 (a)
KP78a 37
  • 56 (a)
KP78b 37
  • 41 (a)
par-1 37
  • 51 (a)
par-1 35
  • 57.2 (n)
  • 61.38 (a)
par-1 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0511.4 37
  • 31 (a)
kin-29 37
  • 39 (a)
par-1 35
  • 57.02 (n)
  • 63.69 (a)
par-1 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for MARK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARK3 Gene

ENSEMBL:
Gene Tree for MARK3 (if available)
TreeFam:
Gene Tree for MARK3 (if available)

Paralogs for MARK3 Gene

Paralogs for MARK3 Gene

Pseudogenes.org Pseudogenes for MARK3 Gene

genes like me logo Genes that share paralogs with MARK3: view

Variants for MARK3 Gene

Sequence variations from dbSNP and Humsavar for MARK3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs13987 -- 103,503,572(+) TCATT(A/G)CTAGT utr-variant-3-prime
rs911556 -- 103,489,158(-) ATCTC(C/T)ATGAA intron-variant
rs911557 -- 103,481,568(-) ACAGA(A/C)CAAAT intron-variant
rs911558 -- 103,481,550(-) CTCAT(A/G)TCAAC intron-variant
rs962230 -- 103,391,200(-) TCCTA(C/T)GTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARK3 Gene

Variant ID Type Subtype PubMed ID
nsv9168 CNV Loss 18304495
esv2676094 CNV Deletion 23128226
nsv832883 CNV Loss 17160897
nsv85420 CNV Loss 16902084
nsv525874 CNV Gain 19592680
nsv85551 CNV Loss 16902084
dgv1992n71 CNV Loss 21882294
nsv902300 CNV Loss 21882294

Relevant External Links for MARK3 Gene

HapMap Linkage Disequilibrium report
MARK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARK3 Gene

Disorders for MARK3 Gene

Relevant External Links for MARK3

Genetic Association Database (GAD)
MARK3
Human Genome Epidemiology (HuGE) Navigator
MARK3

No disorders were found for MARK3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MARK3 Gene

Publications for MARK3 Gene

  1. New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. (PMID: 16980613) Dequiedt F. … Kettmann R. (Mol. Cell. Biol. 2006) 3 4 23
  2. C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. (PMID: 11741534) MA1ller J. … Morrison D.K. (Mol. Cell 2001) 3 23
  3. Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. (PMID: 12941695) MA1ller J. … Morrison D.K. (EMBO J. 2003) 3 23
  4. PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. (PMID: 11433294) Sun T.-Q. … Williams L.T. (Nat. Cell Biol. 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MARK3 Gene

  • Addgene plasmids for MARK3

Sources for MARK3 Gene

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