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MARK3 Gene

protein-coding   GIFtS: 66
GCID: GC14P103851

MAP/Microtubule Affinity-Regulating Kinase 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MAP/Microtubule Affinity-Regulating Kinase 31 2     Par-1a2 3
Cdc25C-Associated Protein Kinase 12 3     ELKL Motif Kinase 22 3
Protein Kinase STK102 3     EC 2.7.11.13 8
Ser/Thr Protein Kinase PAR-12 3     KP782
Serine/Threonine-Protein Kinase P782 3     PAR1A2
C-TAK12 3     EMK23
CTAK12 3     cTAK13
EMK-22 3     EC 2.7.118

External Ids:    HGNC: 68971   Entrez Gene: 41402   Ensembl: ENSG000000754137   OMIM: 6026785   UniProtKB: P274483   

Export aliases for MARK3 gene to outside databases

Previous GC identifers: GC14P101243 GC14P097667 GC14P101841 GC14P102921 GC14P084029


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MARK3 Gene:
The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of
tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for MARK3 Gene:
MARK3 (MAP/microtubule affinity-regulating kinase 3) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is BRSK1.

UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448
Function: Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4.
Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating
phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus

Gene Wiki entry for MARK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MARK3 gene promoter:
         NF-YB   CBF-B   CBF-A   NF-YA   NF-YC   CP1C   CP1A   NF-Y   CBF-C   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MARK3 promoter sequence
   Search Chromatin IP Primers for MARK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.3   Ensembl cytogenetic band:  14q32.32   HGNC cytogenetic band: 14q32.3

MARK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARK3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P103851:  view genomic region     (about GC identifiers)

Start:
103,851,701 bp from pter      End:
103,970,168 bp from pter
Size:
118,468 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448 (See protein sequence)
Recommended Name: MAP/microtubule affinity-regulating kinase 3  
Size: 753 amino acids; 84489 Da
2 PDB 3D structures from and Proteopedia for MARK3:
2QNJ (3D)        3FE3 (3D)    
Secondary accessions: O60219 Q86TT8 Q8TB41 Q8WX83 Q96RG1 Q9UMY9 Q9UN34
Alternative splicing: 7 isoforms:  P27448-5   P27448-2   P27448-3   P27448-4   P27448-6   P27448-7   P27448-8   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MARK3: NX_P27448

Explore proteomics data for MARK3 at MOPED

Post-translational modifications: 

  • Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and
    CAB39. Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity1
  • Ubiquitination2 at Lys317, Lys740
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MARK3 (P27448) (see all 27)
     FAKVKLA  EYASGGE  LVAHGRM  LTGREVA 


    See MARK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001122390.1  NP_001122391.1  NP_001122392.1  NP_001122393.1  NP_002367.4  

    ENSEMBL proteins: 
     ENSP00000402104   ENSP00000408092   ENSP00000411397   ENSP00000303698   ENSP00000216288  
     ENSP00000450772   ENSP00000454169   ENSP00000335347   ENSP00000452829   ENSP00000450460  
     ENSP00000452893   ENSP00000451623  

    MARK3 Human Recombinant Protein Products:

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    Novus Biologicals MARK3 Proteins
    Novus Biologicals MARK3 Lysates
    Sino Biological Recombinant Protein for MARK3
    Sino Biological Cell Lysate for MARK3
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MARK3

     
    Search eBioscience for Proteins for MARK3 

    MARK3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MARK3
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for MARK3 
    OriGene Antibodies for MARK3
    OriGene Custom Antibody Services for MARK3
    Novus Biologicals MARK3 Antibodies
    Abcam antibodies for MARK3 (Q9P0L2, Q96L34)
    Cloud-Clone Corp. Antibodies for MARK3
    ThermoFisher Antibody for MARK3
    LSBio Antibodies in human, mouse, rat for MARK3

    MARK3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MARK3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MARK3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MARK3
    Cloud-Clone Corp. CLIAs for MARK3
    Search eBioscience for ELISAs for MARK3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: MAP/microtubule affinity-regulating kinase 3
    MARK subfamily

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR001772 KA1_dom
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry P27448

    ProtoNet protein and cluster: P27448

    2 Blocks protein domains:
    IPB000449 Ubiquitin-associated domain
    IPB001772 Kinase-associated


    UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily
    Similarity: Contains 1 KA1 (kinase-associated) domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UBA domain


    Find genes that share domains with MARK3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARK3_HUMAN, P27448
    Function: Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4.
    Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating
    phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-211. Inhibited by phosphorylation on Thr-564

         Genatlas biochemistry entry for MARK3:
    MAP/microtubule affinity-regulating kinase 3 deleted in pancreas carcinoma

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA16980613
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI12556533
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with MARK3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MARK3:
     Decreased substrate adherent c  Increased cell death HMECs cel 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mark3):
     adipose tissue  growth/size/body  homeostasis/metabolism  liver/biliary system  mortality/aging 
     no phenotypic analysis 

    Find genes that share phenotypes with MARK3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mark3tm1Hpw for MARK3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MARK3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MARK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARK3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARK3

    miRNA
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    miRTarBase miRNAs that target MARK3:
    hsa-mir-331-3p (MIRT043531)

    Block miRNA regulation of human, mouse, rat MARK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MARK3 (see all 20):
    hsa-miR-142-3p hsa-miR-3607-3p hsa-miR-137 hsa-miR-29a hsa-miR-29c hsa-miR-16-1* hsa-miR-301a hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidMARK3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MARK3
    Predesigned siRNA for gene silencing in human, mouse, rat MARK3

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 5): MARK3 (NM_001128918)
    Sino Biological Human cDNA Clone for MARK3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARK3
    Addgene plasmids for MARK3 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARK3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MARK3_HUMAN, P27448: Cell membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus3
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with MARK3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MARK3 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    2Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    3TGF-beta Signaling Pathway (sino)
    TGF-beta Signaling Pathway
    4Cytoskeletal Signaling
    Cytoskeletal Signaling


    Find genes that share SuperPaths with MARK3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for MARK3
        Wnt / Hedgehog / Notch
    Cytoskeletal Signaling

    1 Sino Biological Pathway for MARK3
        TGF-beta Signaling Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MARK3
    Interactions:

        GeneGlobe Interaction Network for MARK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MARK3 (P274481, 2, 3 ENSP000004113974) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319471, 2, 3, ENSP000003409894EBI-707595,EBI-476295 MINT-66900 MINT-3975719 I2D: score=5 STRING: ENSP00000340989
    PKP2Q999592, 3, ENSP000000708464MINT-16617 MINT-16618 I2D: score=2 STRING: ENSP00000070846
    PNPLA2Q96AD52, 3, ENSP000003377014MINT-63622 I2D: score=5 STRING: ENSP00000337701
    PRKCQQ047592, 3, ENSP000002631254MINT-4787821 I2D: score=3 STRING: ENSP00000263125
    PPM1BO756882, 3, ENSP000002824124MINT-8247539 I2D: score=1 STRING: ENSP00000282412
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    Find genes that share ontologies with MARK3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MARK3

    2 HMDB Compounds for MARK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MARK3 gene (5 alternative transcripts): 
    NM_001128918.1  NM_001128919.1  NM_001128920.1  NM_001128921.1  NM_002376.5  

    Unigene Cluster for MARK3:

    MAP/microtubule affinity-regulating kinase 3
    Hs.35828  [show with all ESTs]
    Unigene Representative Sequence: NM_001128918
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000440884 ENST00000559328 ENST00000560603 ENST00000416682 ENST00000429436(uc001ymz.4 uc001ymx.4 uc001ymw.4 uc001yna.4 uc001ymy.4 uc010awp.3 uc010tyb.2 uc010awq.3)
    ENST00000303622 ENST00000216288 ENST00000553942(uc021sef.1) ENST00000560417
    ENST00000558223 ENST00000335102 ENST00000561225 ENST00000561071 ENST00000558698
    ENST00000560731 ENST00000559268 ENST00000561164 ENST00000554627
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MARK3 (see all 20):
    hsa-miR-142-3p hsa-miR-3607-3p hsa-miR-137 hsa-miR-29a hsa-miR-29c hsa-miR-16-1* hsa-miR-301a hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidMARK3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 5): MARK3 (NM_001128918)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARK3
    Addgene plasmids for MARK3 
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MARK3
      QuantiTect SYBR Green Assays in human, mouse, rat MARK3
      QuantiFast Probe-based Assays in human, mouse, rat MARK3

    Additional mRNA sequence: 

    AF170723.1 AF387637.1 AF465413.1 AK023963.1 AK055814.1 AK056714.1 AK124459.1 AK124796.1 
    AK296643.1 AK307448.1 BC024773.1 BX161395.1 BX248250.1 DQ368336.1 M80359.1 M83780.1 
    U64205.1 

    Selected DOTS entries (see all 37):

    DT.86855293  DT.95264963  DT.100714279  DT.100698434  DT.100844722  DT.100844716  DT.100844721  DT.317922 
    DT.100673793  DT.120767212  DT.100029578  DT.100844711  DT.120767219  DT.120767148  DT.120767164  DT.95124116 
    DT.95264961  DT.97785685  DT.100844733  DT.100844732  DT.449218  DT.95264965  DT.100844734  DT.101979967 

    Selected AceView cDNA sequences (see all 430):

    BM910621 BQ936331 AU132239 BM699216 T28619 BE792279 BX161395 BM011369 
    CB240911 AW138470 AL043945 BG036631 CF552147 BG741259 BI087108 CR598572 
    CB528929 BX248250 BG677520 BE208064 CA433074 BI850828 AI332609 BX119061 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MARK3 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
    SP1:                                                                                                              -     -                             -         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                              -                                   -         
    SP5:                                                        -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -         

    ExUns: 18 ^ 19a · 19b ^ 20a · 20b · 20c · 20d · 20e · 20f · 20g
    SP1:        -                                                   
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:  -     -     -                                             


    ECgene alternative splicing isoforms for MARK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MARK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGTGGTTT
    MARK3 Expression
    About this image


    MARK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Spleen (Hematopoietic System)
    MARK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MARK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.35828

    UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for MARK3
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MARK3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mark31 , 5 MAP/microtubule affinity-regulating kinase 31, 5 90.05(n)1
    96.91(a)1
      12 (61.05 cM)5
    171691  NM_021516.41  NP_067491.21 
     1115745105 
    chicken
    (Gallus gallus)
    Aves MARK31 MAP/microtubule affinity-regulating kinase 3 83.96(n)
    95.7(a)
      423480  XM_004936356.1  XP_004936413.1 
    lizard
    (Anolis carolinensis)
    Reptilia MARK36
    MAP/microtubule affinity-regulating kinase 3
    84(a)
    1 ↔ 1
    GL343232.1(161320-244112)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.19672 Xenopus laevis Ser/Thr protein kinase PAR-1A mRNA, more 79.58(n)    AF509737.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC047179.12   -- 73.64(n)   334300  BC047179.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta KP78a3
    par-11
    protein amino acid phosphorylation
    protein kinase3
    par-11
    56(a)
    (best of 4)3
    57.2(n)1
    61.38(a)1
      86E43
    27688521  NM_206172.31  NP_995894.21 
    worm
    (Caenorhabditis elegans)
    Secernentea kin-293
    par-11
    serine/threonine-protein kinase3
    par-11
    39(a)
    (best of 2)3
    57.02(n)1
    63.69(a)1
      X(2880113-2887689)3
    1799121  NM_001047680.21  NP_001041145.11 


    ENSEMBL Gene Tree for MARK3 (if available)
    TreeFam Gene Tree for MARK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MARK3 gene
    BRSK12  MARK12  BRSK22  SNRK2  SIK32  SIK22  MARK22  NIM1K2  
    SIK12  MARK42  
    Selected SIMAP similar genes for MARK3 using alignment to 7 protein entries:     MARK3_HUMAN (see all proteins) (see all similar genes):
    DKFZp547M202    MARK4    BRSK2    BRSK1    MARK2    KIAA0999
    MARK1    SIK3    HUNK    NUAK2    PHKG2    Par1b
    CDK3    PDPK1    STK32A    Nbla00650    CDKL1    PRKD2

    Find genes that share paralogs with MARK3           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for MARK3
    PGOHUM00000239434 PGOHUM00000237761 PGOHUM00000261899


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MARK3 (see all 2643)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs356114271,2
    C--84037337(+) TTTTTT/-AAATT 5 -- int11Minor allele frequency- -:0.50NA 2
    rs360030651,2
    C--84038294(+) ATTACT/-TTTTT 5 -- int11Minor allele frequency- -:0.50NA 2
    rs616352751,2
    C--84045516(+) TGTGT-/GT/TA/
    TGTGTGTG
    ATGCA
    5 -- int10--------
    rs2006719831,2
    C--84050297(+) TTTTT-/TTTGTA
            
    TTTTT
    5 -- int10--------
    rs114340621,2
    C--84053776(+) TAAGTG/-GGAGT 5 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs589868761,2
    C--84057184(+) ATAGT-/CTGATCT
    GCAA
    /GA/TT
    TCTTC
    5 -- int11NA 2
    rs1408851301,2
    C--84057184(+) TAGTT-/GAT   
      CTGCAA
    CTTCA
    5 -- cds10--------
    rs1396721721,2
    C--84069692(+) ATTTA-/TTAT  
            
    TTATT
    5 -- int10--------
    rs3711718781,2
    C--84077529(+) TTTTC-/T/TTT 
            
    TTTTC
    10 -- int1 cds10--------
    rs2009926581,2
    C--84087092(-) CTGTTA/TTTTTT 5 -- int10--------

    HapMap Linkage Disequilibrium report for MARK3 (103851701 - 103970168 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MARK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676094CNV Deletion23128226
    dgv1992n71CNV Loss21882294
    nsv85551CNV Loss16902084
    nsv85420CNV Loss16902084
    nsv832883CNV Loss17160897
    nsv9168CNV Loss18304495
    nsv902300CNV Loss21882294
    nsv525874CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for MARK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602678    OMIM disorders: --


    Find genes that share disorders with MARK3           About GenesLikeMe

    Genetic Association Database (GAD): MARK3
    Human Genome Epidemiology (HuGE) Navigator: MARK3 (4 documents)

    Export disorders for MARK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MARK3 gene, integrated from 10 sources (see all 67):
    (articles sorted by number of sources associating them with MARK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. (PubMed id 16980613)1, 2, 9 Dequiedt F.... Kettmann R. (Mol. Cell. Biol. 2006)
    2. OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts. (PubMed id 20534768)1, 4 Paternoster L....Tobias J.H. (J. Clin. Endocrinol. Metab. 2010)
    3. Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women. (PubMed id 20554715)1, 4 Liu J.M....Ning G. (J. Clin. Endocrinol. Metab. 2010)
    4. New sequence variants associated with bone mineral density. (PubMed id 19079262)1, 4 Styrkarsdottir U....Stefansson K. (Nat. Genet. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. (PubMed id 11433294)1, 2 Sun T.-Q....Williams L.T. (Nat. Cell Biol. 2001)
    7. C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. (PubMed id 9543386)1, 2 Peng C.Y.... Piwnica-Worms H. (Cell Growth Differ. 1998)
    8. Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization. (PubMed id 9533022)1, 3 Ono T....Okamoto T. (Cytogenet. Cell Genet. 1997)
    9. Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. (PubMed id 12941695)1, 9 MA1ller J....Morrison D.K. (EMBO J. 2003)
    10. C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. (PubMed id 11741534)1, 9 MA1ller J....Morrison D.K. (Mol. Cell 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4140 HGNC: 6897 AceView: MARK3 Ensembl:ENSG00000075413 euGenes: HUgn4140
    ECgene: MARK3 H-InvDB: MARK3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MARK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MARK3 gene:
    Search GeneIP for patents involving MARK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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