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MARK2 Gene

protein-coding   GIFtS: 59

GC11P063606
MAP/microtubule affinity-regulating kinase 2
(Previous name: ELKL motif kinase )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: EMK1)
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Aliases &
Descriptions
for MARK2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

  User Feedback
Aliases & Descriptions
MAP/microtubule affinity-regulating kinase 21 2 3     MGC996192
EMK12 3 5     serine/threonine protein kinase EMK2
Par1b1 2     Ser/Thr protein kinase PAR-1B2
PAR-11 2     EMK-13
ELKL motif kinase 12 3     EC 2.7.11.13
ELKL motif kinase1     PAR1 homolog3

External Ids:    HGNC: 33321   Entrez Gene: 20112   Ensembl: ENSG000000725187   UniProtKB: Q7KZI73   

Search outside databases for aliases for MARK2 gene

Previous GC identifers: GC11P066121 GC11P065286 GC11P063857 GC11P063382 GC11P063431 GC11P063363

Summaries
for MARK2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  User Feedback		 Entrez Gene summary for MARK2:
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important
regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through
phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes.
Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: MARK2_HUMAN, Q7KZI7
Function: Role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic
epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery.
Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may
play a role in graft rejection

Gene Wiki entry for MARK2

Genomic Views
for MARK2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
About This Section

  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the MARK2 gene upstream (promoter) region "":
NF-kappaB1   CREB   deltaCREB   NF-kappaB   p53   PPAR-gamma1   PPAR-gamma2   NRSF form 1   NRSF form 2   IRF-1   

Epigenetics:
"" Search SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for MARK2 ""

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12-q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

MARK2 Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P063606:  view genomic region     (about GC identifiers)

Start:
 63,606,895 bp from pter
End:
 63,677,057 bp from pter
Size:
 70,163 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  

Proteins
for MARK2 gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

  User Feedback		 UniProtKB/Swiss-Prot: MARK2_HUMAN, Q7KZI7 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase MARK2  
Size: 788 amino acids; 87911 Da
Cofactor: Magnesium
Subcellular location: Cell membrane; Peripheral membrane protein. Note=Phosphorylated by PRKCZ in polarized epithelial
cells, resulting in an interaction with YWHAZ which promotes relocation from the lateral to the apical membrane
Sequence caution: Sequence=AAK82368.1; Type=Erroneous initiation;
PDB structures from "" and Proteopedia "" :
3IEC (3D) ""    
Secondary accessions: Q15449 Q15524 Q5XGA3 Q68A18 Q96HB3 Q96RG0
Alternative promoter usage, Alternative splicing: 12 isoforms:  Q7KZI7-1   Q7KZI7-2   Q7KZI7-3   Q7KZI7-4   Q7KZI7-5   Q7KZI7-6   Q7KZI7-7   Q7KZI7-8   
Q7KZI7-9   Q7KZI7-10   Q7KZI7-11   Q7KZI7-12   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (6 alternative transcripts): 
    NP_001034557.1  NP_001034558.2  NP_001156768.1  NP_001156769.1  NP_004945.4  NP_059672.2  


    ENSEMBL proteins: 
    ENSP00000386128 ENSP00000415494 ENSP00000367041 ENSP00000389184 ENSP00000355091 ENSP00000367040 
    ENSP00000326632 ENSP00000385751 ENSP00000265458 ENSP00000294247 


    Human Recombinant Proteins 
    ""Millipore Purified and/or Recombinant MARK2 Protein
    ""Browse Human Recombinant Proteins at Sigma-Aldrich
    "" Browse R&D Systems for human recombinant proteins
    ""Enzo Life Sciences proteins for MARK2
    ""HuPro® and/or Recombinant Proteins from Abnova for MARK2 ""
    ""Browse Origene full length recombinant human proteins expressed in human HEK293 cells
    ""Novus Biologicals Proteins for MARK2  ""
    ""Browse Sino Biological Recombinant Proteins  ""

    5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005886 plasma membrane IEA--
    GO:0016020 membrane IMP14976552
    GO:0019898 extrinsic to membrane ----
    GO:0045180 basal cortex IEA--
    About this table

    "" MARK2 for ontologies           About GeneDecksing



    Antibodies for MARK2: 
    ""Millipore Mono- and Polyclonal Antibodies for the study of MARK2
    ""Sigma-Aldrich Antibodies for MARK2
    "" Browse R&D Systems for Antibodies
    ""Cell Signaling Technology (CST) Antibodies for MARK2 
    ""Monoclonal and Polyclonal Antibodies from Abnova (MARK2)
    "" Origene Antibodies: MARK2 ""
    ""Novus Biologicals Antibodies for MARK2
    ""Browse antibodies at Epitomics

    Assays for MARK2: 
    ""Browse Kits and Assays available from Millipore
    ""Browse ELISAs at Sigma-Aldrich
    "" Browse R&D Systems for biochemical assays
    ""Enzo Life Sciences assays for MARK2

    Protein Domains/
    Families
    for MARK2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

      User Feedback
    "" MARK2 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10 ):
     IPR017441 Protein_kinase_ATP_BS
     IPR001772 Kinase-assoc_KA1
     IPR002290 Ser/Thr_prot_kinase_dom
     IPR020670 MAP/microtub-affin-reg_kin2/4
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q7KZI7

    ProtoNet protein and cluster: Q7KZI7

    2 Blocks protein families:
    IPB000449 Ubiquitin-associated domain
    IPB001772 Kinase-associated


    UniProtKB/Swiss-Prot: MARK2_HUMAN, Q7KZI7
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily
    Similarity: Contains 1 KA1 (kinase-associated) domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UBA domain

    Gene Function
    for MARK2 gene

    (According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (MARK2)
    "" Origene 29mer shRNA kits in GFP-retroviral vector (see all 6): MARK2
    Origene shRNA RFP (see all 6): MARK2
    Origene basic RS shRNA (see all 6): MARK2

    ""Applied Biosystems Silencer® siRNAs for MARK2
    ""Sigma-Aldrich siRNA Panels and siRNA for MARK2
    Sigma-Aldrich shRNA Panels and shRNA for MARK2
    Explore Sigma-Aldrich super-pooled esiRNAs
    Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    ""Browse iPSC Reprogramming Factors at Sigma-Aldrich
    "" Origene GFP tagged cDNA clones in CMV expression vector (see all 8): MARK2
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): MARK2
    Origene untagged cDNA clones in CMV expression vector (see all 8): MARK2
    ""Browse Sino Biological Human cDNA Clones  ""

    UniProtKB/Swiss-Prot: MARK2_HUMAN, Q7KZI7
    Function: Role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic
    epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery.
    Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may
    play a role in graft rejection
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-208 by STK11 in complex with STE20-related adapter-alpha (STRAD
    alpha) pseudo kinase and CAB39
    Enzyme Number (IUBMB): EC 2.7.11.1 

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0000287 magnesium ion binding IDA14976552
    GO:0004672 protein kinase activity ----
    GO:0004674 protein serine/threonine kinase activity NAS8274451
    GO:0005515 protein binding IPI14676191 15324659
    About this table

    "" MARK2 for ontologies           About GeneDecksing

    Animal Models: 15/16 MGI mutant phenotypes (inferred from 3 alleles"") (MGI details for Mark2) (see all 16 ):

    adipose tissuebehavior/neurologicalcardiovascular systemdigestive/alimentaryembryogenesis
    endocrine/exocrine glandgrowth/sizehematopoietic systemhomeostasis/metabolismimmune system
    lethality-postnatalliver/biliary systemnervous systemrenal/urinary systemreproductive system

    "" MARK2 for phenotypes           About GeneDecksing

    Pathways & Interactions
    for MARK2 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
    About This Section

      User Feedback
    "" MARK2 for pathways           About GeneDecksing

    1 "" Millipore Pathway for MARK2
      ""  Cytoplasmic microtubules

    2 "" Sigma-Aldrich "Your Favorite Gene" Pathways for  MARK2  (Your Favorite Gene powered by Ingenuity)
      ""  Wnt/?-catenin Signaling
    Tight Junction Signaling

    1 "" GeneAssist Pathway for MARK2
      ""  Epithelial Tight Junctions

    1 "" Cell Signaling Technology (CST) Pathway for MARK2: 
      ""  Wnt/b-Catenin Signaling

    "" SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MARK2

    5 Interacting proteins for MARK2 (Q7KZI71, 2 ENSP000002654583) via UniProtKB, MINT, and/or STRING ""
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631041, 2, ENSP000003095033EBI-516560,EBI-347088 MINT-3294585 MINT-3295456 MINT-3294883 EBI-516560,EBI-347088 MINT-3294585 MINT-3295456 MINT-3294883 STRING: ENSP00000309503
    PARD6GQ9BYG41EBI-516560,EBI-295417
    MAP3K3Q997592MINT-48484 MINT-47995
    SFNP319472MINT-3975077
    YWHABP319462MINT-51527
    About this table

    5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468 protein amino acid phosphorylation NAS8274451
    GO:0006979 response to oxidative stress IEP16551573
    GO:0007243 intracellular protein kinase cascade IDA14976552
    GO:0007275 multicellular organismal development IEA--
    GO:0030154 cell differentiation IEA--
    About this table

    "" MARK2 for ontologies           About GeneDecksing


    Drugs & Compounds
    for MARK2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

      User Feedback
    "" MARK2 for compounds           About GeneDecksing

    "" Enzo Life Sciences drugs & compounds for MARK2
    ""Browse Small Molecules at Sigma-Aldrich

    "" Browse Tocris compounds for MARK2
    10/11 ""Novoseek chemical compound relationships for MARK2 gene (see all 11 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    hymenialdisine 3.34 1 12429843 (1)
    threonine 2.92 3 9259552 (1), 18641122 (1), 16707567 (1)
    map4 2.59 1 14517247 (1)
    serine 1.74 3 9259552 (1), 18641122 (1), 16707567 (1)
    phosphoserine 1.63 1 12431373 (1)
    licl 1.26 1 16257959 (1)
    ionomycin 1.21 1 17442826 (1)
    okadaic acid 1.12 1 15324659 (1)
    tyrosine 0.43 2 19016760 (1), 18192401 (1)
    glycogen 0.42 1 16257959 (1)
    About this table


    Transcripts
    for MARK2 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
    Expression Assays from Applied Biosystems)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (MARK2)
    ""Applied Biosystems Silencer® siRNAs:  NM_001039469  NM_001163296  NM_001163297  NM_004954  NM_017490  
    "" Origene 29mer shRNA kits in GFP-retroviral vector (see all 6): MARK2
    Origene shRNA RFP (see all 6): MARK2
    Origene basic RS shRNA (see all 6): MARK2

    ""Sigma-Aldrich siRNA Panels and siRNA for MARK2
    Sigma-Aldrich shRNA Panels and shRNA for MARK2
    Explore Sigma-Aldrich super-pooled esiRNAs

    microRNA:""4 SABiosciences microRNAs that regulate MARK2: ""
    hsa-miR-299-5p hsa-miR-214 hsa-miR-19b hsa-miR-19a
    Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
    NM_001039469  NM_001163296  NM_001163297  NM_004954  NM_017490  


    Clones:"" Origene GFP tagged cDNA clones in CMV expression vector (see all 8): MARK2
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): MARK2
    Origene untagged cDNA clones in CMV expression vector (see all 8): MARK2
    Primers:"" Origene genome-wide validated SYBR primer pairs: MARK2
    ""SABiosciences RT2 qPCR Primer Assay for MARK2: PPH13048A ""

    REFSEQ mRNAs for MARK2 gene (6 alternative transcripts): 

    NM_001039468.1  NM_001039469.2  NM_001163296.1  NM_001163297.1  NM_004954.4  NM_017490.3  

    Additional cDNA sequence: 

    AB188493.1 AB271694.1 AF387638.1 AK225766.1 AK290339.1 AK307858.1 AY562187.1 AY562188.1 
    BC008771.2 BC084540.1 BT007342.1 CR602633.1 X97630.1 Z25427.1 

    14 DOTS entries:

    DT.92469486  DT.120760201  DT.95152384  DT.86854993  DT.95276568  DT.100690476  DT.100819081  DT.95340835 
    DT.100819082  DT.95239808  DT.92001043  DT.92469437  DT.95276588  DT.95328531 

    24/204 AceView cDNA sequences (see all 204 ):

    AI818608 AI380486 AI870094 BX363849 BT007342 BM672157 AI248877 AW150937 
    BM762212 BE278938 AI370467 CR602633 BF002715 AW138519 BM142145 AA324104 
    BQ066750 BC008771 BM912801 AA369656 BM700779 BI791440 AW295498 AI394102 

    "" highest scoring ESTs for MARK2:

    X97630 AA159980 AA613444 AA617763 AA827742 AI248877 AI370467 AI380486 AI394102 AI472858 

    Unigene Cluster for MARK2:

    MAP/microtubule affinity-regulating kinase 2
    Hs.567261  [show with all ESTs]
    Unigene Representative Sequence: NM_001039469


    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for MARK2 (see all 11 )

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^
    SP1:                                            -                             -                                                                                 
    SP2:                                                                          -                                                                                 
    SP3:              -     -     -     -     -     -                             -                                                                                 
    SP4:              -     -     -     -     -     -                             -                                                                                 
    SP5:                    -     -     -     -     -                             -                                                                                 

    ExUns: 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
    SP1:        -                 -               
    SP2:        -                                 
    SP3:        -     -           -               
    SP4:        -     -                           
    SP5:                                          

    About this scheme

    ECgene alternative splicing isoforms for MARK2

    10 Ensembl transcripts including schematic representations:
    ENST00000408948  ENST00000425897  ENST00000377810  ENST00000413835  ENST00000361128  ENST00000377809  
    ENST00000315032  ENST00000402010  ENST00000265458  ENST00000350490  

    Expression
    for MARK2 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
    About This Section

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    MARK2 expression in normal and diseased human tissues

    "" Applied Biosystems TaqMan ® Gene Expression Assays for MARK2

    1""  / 2""  / 3""

    8 probe-sets matching MARK2 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    965_at2, 3 U95-A 1 1.00 1.00 -0.27 0.10 X97630 1.00 0.90 0.95 1
    84427_i_at2, 3 U95-E 1 1.00 1.00 0.91 0.97 AA813690 0.60 1.00 0.82 1
    1282_s_at2, 3 U95-A 1 1.00 1.00 0.46 0.50 HG2705-HT2801 0.20 1.00 0.72 1
    84431_r_at2, 3 U95-E 1 0.94 1.00 0.67 1.56 AA813690 0.60 1.00 0.82 1
    203942_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_017490 0.60 1.00 0.82 1
    211082_x_at2, 3 U133-A 2 0.82 0.94 -- -- Z25427 0.40 1.00 0.76 1
    203942_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    211082_x_at2 U133Plus2 2 0.82 0.94 -- -- -- -- -- -- --
    About this table

    "" MARK2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTTGTGGGGG

    SOURCE GeneReport for Unigene cluster: Hs.567261

    Expression variation in blood from EXPOLDB for MARK2

    UniProtKB/Swiss-Prot: MARK2_HUMAN, Q7KZI7
    Tissue specificity: High levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in
    lung, liver and kidney

    Primers:"" Origene genome-wide validated SYBR primer pairs: MARK2 ""
    ""SABiosciences RT2 qPCR Primer Assay for MARK2: PPH13048A ""

    Orthologs
    for MARK2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

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    Orthologs for MARK2 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 MARK21   -- MAP/microtubule affinity-regulating kinase 2 94.59(n)
    98.93(a)    		 483769  XM_540890.2  XP_540890.2 
    cow
    (Bos taurus)    		 MARK21   -- MAP/microtubule affinity-regulating kinase 2 94.45(n)
    98.52(a)    		 535197  XM_615209.3  XP_615209.3 
    rat
    (Rattus norvegicus)    		 Mark21   -- MAP/microtubule affinity-regulating kinase 2 92.02(n)
    97.39(a)    		 60328  NM_021699.1  NP_067731.1 
    mouse
    (Mus musculus)    		 Mark21, 5 19 (3.00 cM)5
    		 MAP/microtubule affinity-regulating kinase 21, 5 92.96(n)1
    98.25(a)1    		 137281  NM_007928.21  NP_031954.21 
     AK0453295  AK1430135  (see all 35)
    zebrafish
    (Danio rerio)    		 wu:fc75f051   -- wu:fc75f05 72.46(n)
    79.42(a)    		 562231  XM_681460.2  XP_686552.2 
    About this table        Species with no ortholog for MARK2

    ENSEMBL Gene Tree for MARK2

    Paralogs
    for MARK2 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

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    Paralogs for MARK2 gene
    BRSK12  MARK12  BRSK22  SIK32  MGC421052  TSSK62  TSSK32  TSSK22  
    TSSK42  MARK32  MARK42  TSSK1B2  NUAK12  SNRK2  SIK22  NUAK22  
    SIK12  

    "" MARK2 for paralogs           About GeneDecksing


    Genomic Variants
    for MARK2 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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    10/49 NCBI SNPs in MARK2 are shown (see all 49 )
    (Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 77)
    ABGenomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    ""
    rs18727721,2
    		C,F,A,H59984502(-) CCTGTA/GGCAGG 3 -- int1 ng51""7Minor allele frequency- G:0.37NS EA NA WA 712""
    ""
    rs1509011,2
    		C,H59984620(-) CTCCCT/CCCCTC 3 -- int1 ng51 trp3""1Minor allele frequency- C:0.00NA 2""
    --
    rs2241731,2
    		C,A59989348(-) caacaC/Taggga 4 -- int1 ng51""2Minor allele frequency- T:0.00NA 4""
    --
    rs10571781,2
    		H59998398(+) CCCATC/TCCCAT 8 S F ref1 mis1 ese3""5Minor allele frequency- T:0.00MN NS EA 588""
    --
    rs30197851,2
    		C59990550(-) ctgcgT/Cccagc 4 -- int1 ng51""1Minor allele frequency- C:0.00NA 2""
    ""
    rs10571771,2
    		H59998395(+) CGCCCC/AATCCC 8 /Q /P mis1 ref1 ese3""5Minor allele frequency- A:0.00MN NS EA 586""
    ""
    rs3201061,2
    		C60005180(+) CAGAGC/TGAGCT 8 S ref1 syn1 ese3""1Minor allele frequency- T:0.00MN 184""
    ""
    rs3201071,2
    		C60005225(+) ACGCCG/AGGCCA 8 /P syn1 ref1 ese3""1Minor allele frequency- A:0.00MN 184""
    ""
    rs9289481,2
    		C,F,A,H59968628(-) TGCTTC/TGCCGG 1 -- int1""16Minor allele frequency- T:0.44NA EA MN NS WA 1190""
    ""
    rs4490471,2
    		C,F,A,H59936877(-) TGAAAG/TAAAGG 1 -- int1 trp3""11Minor allele frequency- T:0.23MN NA EA WA 762""
    About this table

    HapMap Linkage Disequilibrium images for MARK2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
          Database of Genomic Variants (DGV) variations for MARK2: --

    Disorders & Mutations
    for MARK2 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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    "" MARK2 for disorders           About GeneDecksing

    OMIM: 600526

    10 ""Novoseek disease relationships for MARK2 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    chronic allograft nephropathy 3.58 2 15158914 (2)
    adenocarcinoma gastric 1.38 1 18005242 (1)
    ulcer 0.97 2 18315603 (2)
    melanoma 0.71 2 18315603 (2)
    neuroblastoma 0.52 1 12429843 (1)
    malformation 0.34 1 15324659 (1)
    cysts 0.22 1 11245586 (1)
    ad 0.11 1 17234589 (1)
    breast cancer 0.04 1 17695512 (1)
    cancer 0.00 1 9730619 (1)
    About this table

    Human Genome Epidemiology Navigator: MARK2 (1 document)

    Medical News
    for MARK2 gene

    (Possibly Related Articles in Doctor's Guide)
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    Publications
    for MARK2 gene

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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      User Feedback    		10/69 PubMed articles for MARK2 gene (see all 69 ):

    Search for MARK2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    OMIM
    NCBI Bookshelf
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    Genome Databases showing MARK2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2011 HGNC: 3332 AceView: MARK2 Ensembl:ENSG00000072518 euGenes: HUgn2011
    ECgene: MARK2 H-InvDB: MARK2

    Other Databases showing MARK2 gene

    (According to HUGE)
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      User Feedback    		   --

    Specialized Databases showing MARK2 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    ATLAS Chromosomes in Cancer entry for MARK2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MARK2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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      User Feedback    		Patent Information for MARK2 gene: ""
    Search GeneIP for patents involving MARK2

    GeneCards and IP: ""
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search


    Services
    for MARK2 gene

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
    Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
    Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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    ""
    Products for MARK2:
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    """"""""
    "" Antibodies & Assays for MARK2 

    "" Tagged/untagged cDNA clones
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    "" Regulatory tfbs in MARK2 upstream (promoter) region
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    "" microRNAs that regulate MARK2
    """"""""
    "" Assays/Drugs/Proteins for MARK2
    "" Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
    "" Novus Tissue Slides
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