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MARK2 Gene

protein-coding   GIFtS: 64
GCID: GC11P063606

MAP/Microtubule Affinity-Regulating Kinase 2

(Previous name: ELKL motif kinase)
(Previous symbol: EMK1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MAP/Microtubule Affinity-Regulating Kinase 21 2 3     ELKL Motif Kinase1
EMK11 2 3 5     Protein-Serine/Threonine Kinase1
ELKL Motif Kinase 11 2 3     Serine/Threonine Kinase1
Ser/Thr Protein Kinase PAR-1B1 2     PAR-12
EMK-12 3     Serine/Threonine Protein Kinase EMK2
Par-1b2 3     Serine/Threonine-Protein Kinase MARK22
Par1b2 3     EC 2.7.11.263
PAR1 Homolog B2 3     PAR1 Homolog3
EC 2.7.11.13 8     EC 2.7.118

External Ids:    HGNC: 33321   Entrez Gene: 20112   Ensembl: ENSG000000725187   OMIM: 6005265   UniProtKB: Q7KZI73   

Export aliases for MARK2 gene to outside databases

Previous GC identifers: GC11P066121 GC11P065286 GC11P063857 GC11P063382 GC11P063431 GC11P063363 GC11P059934


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MARK2 Gene:
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important
regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules
through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to
cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. (provided
by RefSeq, Jul 2009)

GeneCards Summary for MARK2 Gene:
MARK2 (MAP/microtubule affinity-regulating kinase 2) is a protein-coding gene. Diseases associated with MARK2 include asthenopia, and gastric adenocarcinoma. GO annotations related to this gene include lipid binding and protein serine/threonine kinase activity. An important paralog of this gene is BRSK1.

UniProtKB/Swiss-Prot: MARK2_HUMAN, Q7KZI7
Function: Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation.
Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell
polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing
detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating
RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular
polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by
phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent
accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates
localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting
subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of
the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or
DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by
promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric
development of membrane domains of polarized epithelial cells

Gene Wiki entry for MARK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MARK2 gene promoter:
         PPAR-gamma1   AP-2alpha isoform 3   PPAR-gamma2   AP-2alpha isoform 2   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MARK2 promoter sequence
   Search Chromatin IP Primers for MARK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

MARK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARK2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P063606:  view genomic region     (about GC identifiers)

Start:
63,606,400 bp from pter      End:
63,678,492 bp from pter
Size:
72,093 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MARK2_HUMAN, Q7KZI7 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase MARK2  
Size: 788 amino acids; 87911 Da
Cofactor: Magnesium (By similarity)
Subunit: Homodimer. Interacts with PAK7/PAK5; leading to inhibit the protein kinase activity (By similarity).
Interacts (when phosphorylated at Thr-596) with YWHAZ. In case of infection, interacts with H.pylori CagA,
leading to inhibit kinase activity and junctional and polarity defects
Sequence caution: Sequence=AAK82368.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for MARK2:
3IEC (3D)    
Secondary accessions: Q15449 Q15524 Q5XGA3 Q68A18 Q96HB3 Q96RG0
Alternative promoter usage, Alternative splicing: 16 isoforms:  Q7KZI7-1   Q7KZI7-2   Q7KZI7-3   Q7KZI7-4   Q7KZI7-5   Q7KZI7-6   Q7KZI7-7   Q7KZI7-8   
Q7KZI7-9   Q7KZI7-10   Q7KZI7-11   Q7KZI7-12   Q7KZI7-13   Q7KZI7-14   Q7KZI7-15   Q7KZI7-16   
(Produced by alternative splicing of isoform 1. Contains a phosphoserine at position 409)

Explore the universe of human proteins at neXtProt for MARK2: NX_Q7KZI7

Explore proteomics data for MARK2 at MOPED

Post-translational modifications: 

  • Autophosphorylated. Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA)
    pseudo kinase and CAB39. Phosphorylation at Thr-208 by TAOK1 activates the kinase activity, leading to
    phosphorylation and detachment of MAPT/TAU from microtubules. Phosphorylation at Ser-212 by GSK3-beta (GSK3B)
    inhibits the kinase activity. Phosphorylation by CaMK1 promotes activity and is required to promote neurite
    outgrowth. Phosphorylation at Thr-596 by PRKCZ/aPKC in polarized epithelial cells inhibits the kinase activity
    and promotes binding to 14-3-3 protein YWHAZ, leading to relocation from cell membrane to cytoplasm1
  • Ubiquitination2 at Lys637
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MARK2 (Q7KZI7) (see all 23)
     FRQIVSA  FAKVKLA  EYASGGE  LVAHGRM 


    See MARK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001034558.2  NP_001156768.1  NP_001156769.1  NP_004945.4  NP_059672.2  

    ENSEMBL proteins: 
     ENSP00000425765   ENSP00000355091   ENSP00000294247   ENSP00000423452   ENSP00000444956  
     ENSP00000444859   ENSP00000437509   ENSP00000423974   ENSP00000423844   ENSP00000421075  
     ENSP00000386128   ENSP00000415494   ENSP00000385751   ENSP00000326632   ENSP00000367040  
     ENSP00000389184   ENSP00000367041  

    MARK2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MARK2 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MARK2
    OriGene Protein Over-expression Lysate for MARK2
    OriGene MassSpec for MARK2
    OriGene Custom Protein Services for MARK2
    GenScript Custom Purified and Recombinant Proteins Services for MARK2
    Novus Biologicals MARK2 Proteins
    Novus Biologicals MARK2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MARK2

    MARK2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MARK2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for MARK2 
    OriGene Antibodies for MARK2
    OriGene Custom Antibody Services for MARK2
    Novus Biologicals MARK2 Antibodies
    Abcam antibodies for MARK2 (Q7KZI7, Q9P0L2, Q96L34)
    Cloud-Clone Corp. Antibodies for MARK2
    ThermoFisher Antibodies for MARK2
    LSBio Antibodies in human, mouse, rat for MARK2

    MARK2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MARK2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MARK2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MARK2
    Cloud-Clone Corp. CLIAs for MARK2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: MAP/microtubule affinity-regulating kinase 2
    MARK subfamily

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR001772 KA1_dom
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q7KZI7

    ProtoNet protein and cluster: Q7KZI7

    2 Blocks protein domains:
    IPB000449 Ubiquitin-associated domain
    IPB001772 Kinase-associated


    UniProtKB/Swiss-Prot: MARK2_HUMAN, Q7KZI7
    Domain: The UBA domain does not seem to bind ubiquitin and ubiquitin-like and might play a role in regulating the
    enzyme conformation and localization. Activation of the kinase activity following phosphorylation at Thr-208 is
    accompanied by a conformational change that alters the orientation of the UBA domain with respect to the
    catalytic domain
    Domain: The KA1 domain mediates binding to phospholipids and targeting to membranes (By similarity)
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily
    Similarity: Contains 1 KA1 (kinase-associated) domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UBA domain


    MARK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARK2_HUMAN, Q7KZI7
    Function: Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation.
    Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell
    polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing
    detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating
    RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular
    polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by
    phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent
    accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates
    localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting
    subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of
    the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or
    DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by
    promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric
    development of membrane domains of polarized epithelial cells
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Catalytic activity: ATP + [tau protein] = ADP + [tau protein] phosphate
    Enzyme regulation: Inhibited by PAK7/PAK5; inhibition is independent of the kinase activity of PAK7/PAK5 (By
    similarity). Activated by phosphorylation on Thr-208. Inhibited by phosphorylation at Ser-212 and Thr-596.
    Inhibited by hymenialdisine. Specifically inhibited by the H.pylori CagA peptide FPLKRHDKVDDLSK that mimics host
    substrates and binds to the kinase substrate-binding site

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112 EC 2.7.11.261

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA14976552
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity NAS8274451
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI14676191
         
    MARK2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for MARK2:
     Decreased 12E8 tau but not tot  Decreased focal adhesion (FA)   Decreased substrate adherent c  Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mark2) (see all 16):
     adipose tissue  behavior/neurological  cardiovascular system  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  nervous system  renal/urinary system  reproductive system 

    MARK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mark2tm1Hpw for MARK2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MARK2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MARK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARK2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARK2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MARK2:
    hsa-mir-93-5p (MIRT048862), hsa-mir-99a-5p (MIRT048691), hsa-mir-320a (MIRT044813), hsa-mir-193b-3p (MIRT041517)

    Block miRNA regulation of human, mouse, rat MARK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MARK2 (see all 111):
    hsa-miR-640 hsa-miR-520e hsa-miR-193a-3p hsa-miR-1321 hsa-miR-3194-5p hsa-miR-578 hsa-miR-519a hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidMARK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MARK2
    Predesigned siRNA for gene silencing in human, mouse, rat MARK2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MARK2

    Clone
    Products:
         
    OriGene clones in human, mouse for MARK2 (see all 38)
    OriGene ORF clones in mouse, rat for MARK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): MARK2 (NM_017490)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARK2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MARK2
    Browse ESI BIO Cell Lines and PureStem Progenitors for MARK2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARK2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MARK2_HUMAN, Q7KZI7: Cell membrane; Peripheral membrane protein. Cytoplasm. Note=Phosphorylation at Thr-596 by
    PRKCZ/aPKC and subsequent interaction with 14-3-3 protein YWHAZ promotes relocation from the cell membrane to the
    cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus3
    cytoskeleton2
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005884actin filament IDA--
    GO:0005886plasma membrane IDA--
    GO:0016020membrane IMP14976552
    GO:0016328lateral plasma membrane IDA--

    MARK2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MARK2 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt Signaling Pathway NetPath0.37
    2Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    3Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    4TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    5Regulation of Microtubule Cytoskeleton
    Regulation of Microtubule Cytoskeleton

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MARK2
        Epithelial Tight Junctions

    3 Cell Signaling Technology (CST) Pathways for MARK2
        Neuroscience
    Cytoskeletal Signaling
    Glucose / Energy Metabolism

    5 BioSystems Pathways for MARK2
        Wnt Signaling Pathway NetPath
    TNF-alpha/NF-kB Signaling Pathway
    LKB1 signaling events
    Notch signaling pathway
    Regulation of Microtubule Cytoskeleton



    MARK2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MARK2: 
              Cytoskeleton Regulators in human mouse rat
              Tight Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MARK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MARK2 (Q7KZI71, 2, 3 ENSP000003891844) via UniProtKB, MINT, STRING, and/or I2D (see all 673)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAHQ049171, 2, 3, ENSP000002489754EBI-516560,EBI-306940 MINT-8009011 MINT-8009018 I2D: score=3 STRING: ENSP00000248975
    YWHABP319461, 2, 3, ENSP000003001614EBI-516560,EBI-359815 MINT-51527 I2D: score=3 STRING: ENSP00000300161
    ARHGEF2Q929742, 3, ENSP000003153254MINT-7947479 I2D: score=2 STRING: ENSP00000315325
    YWHAEP622582, 3, ENSP000002643354MINT-7947479 I2D: score=2 STRING: ENSP00000264335
    SFNP319472, 3MINT-3975077 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration ISS--
    GO:0006468protein phosphorylation NAS8274451
    GO:0010976positive regulation of neuron projection development IDA12429843
    GO:0016055Wnt signaling pathway IEA--
    GO:0030010establishment of cell polarity TAS16775013

    MARK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MARK2

    3 HMDB Compounds for MARK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 Novoseek inferred chemical compound relationship for MARK2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 32.1 1 16257959 (1)



    MARK2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MARK2 gene (5 alternative transcripts): 
    NM_001039469.2  NM_001163296.1  NM_001163297.1  NM_004954.4  NM_017490.3  

    Unigene Cluster for MARK2:

    MAP/microtubule affinity-regulating kinase 2
    Hs.567261  [show with all ESTs]
    Unigene Representative Sequence: NM_001039469
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508192 ENST00000361128 ENST00000350490 ENST00000502399 ENST00000543220
    ENST00000543674 ENST00000540169 ENST00000509502(uc009yox.2) ENST00000512060
    ENST00000513765 ENST00000408948 ENST00000425897 ENST00000535116 ENST00000402010(uc001nxw.3)
    ENST00000315032(uc001nxz.4 uc009yoy.3) ENST00000377809 ENST00000413835(uc001nxx.3)
    ENST00000377810(uc001nxv.4 uc001nxy.3)

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    Selected qRT-PCR Assays for microRNAs that regulate MARK2 (see all 111):
    hsa-miR-640 hsa-miR-520e hsa-miR-193a-3p hsa-miR-1321 hsa-miR-3194-5p hsa-miR-578 hsa-miR-519a hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidMARK2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MARK2
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    OriGene ORF clones in mouse, rat for MARK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): MARK2 (NM_017490)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARK2
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat MARK2
      QuantiFast Probe-based Assays in human, mouse, rat MARK2

    Additional mRNA sequence: 

    AB188493.1 AB271694.1 AF387638.1 AK225766.1 AK290339.1 AK307858.1 AY562187.1 AY562188.1 
    BC008771.2 BC084540.1 BT007342.1 X97630.1 Z25427.1 

    14 DOTS entries:

    DT.92469486  DT.120760201  DT.95152384  DT.86854993  DT.95276568  DT.100690476  DT.100819081  DT.95340835 
    DT.100819082  DT.95239808  DT.92001043  DT.92469437  DT.95328531  DT.97804175 

    Selected AceView cDNA sequences (see all 204):

    BI791440 AW138519 CR602633 AI870094 AI611105 BM263187 BE278938 AW150937 
    AI248877 BT007342 BM912801 BF057129 BM700779 AA369656 AF387638 AI394102 
    BM562341 BF002715 AA324104 BM142145 BQ955537 BQ066750 AI380486 BF590710 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MARK2 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^
    SP1:                                            -                             -                                                                                 
    SP2:                                                                          -                                                                                 
    SP3:              -     -     -     -     -     -                             -                                                                                 
    SP4:              -     -     -     -     -     -                             -                                                                                 
    SP5:                    -     -     -     -     -                             -                                                                                 

    ExUns: 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
    SP1:        -                 -               
    SP2:        -                                 
    SP3:        -     -           -               
    SP4:        -     -                           
    SP5:                                          


    ECgene alternative splicing isoforms for MARK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MARK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTGGGGG
    MARK2 Expression
    About this image


    MARK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    MARK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MARK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567261

    UniProtKB/Swiss-Prot: MARK2_HUMAN, Q7KZI7
    Tissue specificity: High levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed
    in lung, liver and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MARK2: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MARK2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mark21 , 5 MAP/microtubule affinity-regulating kinase 21, 5 93.08(n)1
    98.32(a)1
      19 (5.32 cM)5
    137281  NM_007928.31  NP_031954.21 
     72753965 
    lizard
    (Anolis carolinensis)
    Reptilia MARK26
    MAP/microtubule affinity-regulating kinase 2
    78(a)
    1 ↔ 1
    GL343699.1(58189-197672)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043730.12   -- 77.61(n)    BC043730.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mark2b1 MAP/microtubule affinity-regulating kinase 2b 70.63(n)
    76.64(a)
      100005996  XM_001924013.3  XP_001924048.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta par-16
    par-1
    35(a)
    1 → many
    2R(15343679-15373191)
    worm
    (Caenorhabditis elegans)
    Secernentea par-16
    Protein PAR-1, isoform d
    35(a)
    1 → many
    V(14112039-14141119) WBGene00003916


    ENSEMBL Gene Tree for MARK2 (if available)
    TreeFam Gene Tree for MARK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MARK2 gene
    BRSK12  MARK12  BRSK22  SNRK2  SIK32  SIK22  NIM1K2  SIK12  
    MARK42  MARK32  
    Selected SIMAP similar genes for MARK2 using alignment to 7 protein entries:     MARK2_HUMAN (see all proteins) (see all similar genes):
    Par1b    DKFZp547M202    MARK4    BRSK1    MARK1    BRSK2
    MARK3    KIAA0999    HUNK    BRAF    PDPK1    PRKAA1
    NIM1K    STK32A    CDK3    NUAK1    CAMK2A    NEK8

    MARK2 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for MARK2 (see all 23)
    PGOHUM00000238567 PGOHUM00000238578 PGOHUM00000238891 PGOHUM00000242627 PGOHUM00000258641


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MARK2 (see all 1454)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1123598201,2
    F--59954434(+) GCATGC/TGCCAC 4 -- int11Minor allele frequency- T:0.50CSA 2
    rs760494541,2
    F--63524869(+) AGCAGC/GCTTGT 4 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1462940241,2
    --63525001(+) AGACGA/GGAGTG 4 -- us2k10--------
    rs1883972511,2
    --63525049(+) CTGCTA/TCCTCT 4 -- us2k10--------
    rs1818345991,2
    --63525181(+) AGTGAG/TGTGTT 4 -- us2k10--------
    rs734922801,2
    C,F--63525275(+) CTGGTG/ATGGGG 4 -- us2k11Minor allele frequency- A:0.50WA 2
    rs107924211,2
    C,F,A,H--63525436(+) TGGGAG/ATTGGA 4 -- us2k119Minor allele frequency- A:0.48NS EA NA WA 2342
    rs1420027061,2
    --63525548(+) TCCTGC/TGGGGC 4 -- us2k10--------
    rs112316031,2
    C,F,H--63525922(+) CAAAGG/ACAAAG 4 -- us2k113Minor allele frequency- A:0.03NS EA NA WA 1788
    rs1506749911,2
    --63526129(+) AGCCAA/GGATAG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for MARK2 (63606400 - 63678492 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MARK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660413CNV Deletion23128226
    esv2671472CNV Deletion23128226
    dgv1156n71CNV Loss21882294
    dgv1157n71CNV Loss21882294
    dgv1155n71CNV Loss21882294
    dgv1158n71CNV Loss21882294
    nsv897634CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600526    OMIM disorders: --

    8 diseases for MARK2:    
    About MalaCards
    asthenopia    gastric adenocarcinoma    parkinson's disease    neuronitis
    adenocarcinoma    melanoma    hepatitis    malaria


    MARK2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): MARK2
    Human Genome Epidemiology (HuGE) Navigator: MARK2 (1 document)

    Export disorders for MARK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MARK2 gene, integrated from 10 sources (see all 103):
    (articles sorted by number of sources associating them with MARK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human serine/threonine protein kinase EMK1: genome structure and cDNA cloning of isoforms produced by alternative splicing. (PubMed id 9730619)1, 2, 3, 9 Espinosa L. and Navarro E. (Cytogenet. Cell Genet. 1998)
    2. Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity. (PubMed id 12429843)1, 2, 9 Biernat J.... Mandelkow E.M. (Mol. Biol. Cell 2002)
    3. High loading dose of clopidogrel is unable to satisfactorily inhibit platelet reactivity in patients with glycoprotein IIIA gene polymorphism: a genetic substudy of PRAGUE-8 trial. (PubMed id 19530321)1, 4, 9 Motovska Z....Kala P. (amp 2009)
    4. aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity. (PubMed id 15324659)1, 2, 9 Suzuki A.... Ohno S. (Curr. Biol. 2004)
    5. Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation. (PubMed id 20194617)1, 2 Yoshimura Y.... Miki H. (Mol. Cell. Biol. 2010)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    7. The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation. (PubMed id 16396636)1, 2 Jaleel M....Alessi D.R. (Biochem. J. 2006)
    8. New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. (PubMed id 16980613)1, 2 Dequiedt F.... Kettmann R. (Mol. Cell. Biol. 2006)
    9. MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells. (PubMed id 16775013)1, 2 Ducharme N.A.... Goldenring J.R. (Mol. Biol. Cell 2006)
    10. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2011 HGNC: 3332 AceView: MARK2 Ensembl:ENSG00000072518 euGenes: HUgn2011
    ECgene: MARK2 H-InvDB: MARK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MARK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MARK2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MARK2 gene:
    Search GeneIP for patents involving MARK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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