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Aliases for MARK1 Gene

Aliases for MARK1 Gene

  • MAP/Microtubule Affinity-Regulating Kinase 1 2 3 4
  • PAR1 Homolog C 3 4
  • EC 2.7.11.1 4 63
  • KIAA1477 4 6
  • Par-1c 3 4
  • Par1c 3 4
  • MARK 3 4
  • Serine/Threonine-Protein Kinase MARK1 3
  • EC 2.7.11.26 4
  • EC 2.7.11 63

External Ids for MARK1 Gene

Previous GeneCards Identifiers for MARK1 Gene

  • GC01P219297
  • GC01P216545
  • GC01P217248
  • GC01P217758
  • GC01P217757
  • GC01P217089
  • GC01P218768
  • GC01P220701
  • GC01P191375

Summaries for MARK1 Gene

GeneCards Summary for MARK1 Gene

MARK1 (MAP/Microtubule Affinity-Regulating Kinase 1) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Glucose / Energy Metabolism. GO annotations related to this gene include protein serine/threonine kinase activity and phosphatidylinositol-4,5-bisphosphate binding. An important paralog of this gene is MARK4.

UniProtKB/Swiss-Prot for MARK1 Gene

  • Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).

Gene Wiki entry for MARK1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARK1 Gene

Genomics for MARK1 Gene

Regulatory Elements for MARK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MARK1 Gene

Start:
220,528,183 bp from pter
End:
220,664,461 bp from pter
Size:
136,279 bases
Orientation:
Plus strand

Genomic View for MARK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARK1 Gene

Proteins for MARK1 Gene

  • Protein details for MARK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0L2-MARK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase MARK1
    Protein Accession:
    Q9P0L2
    Secondary Accessions:
    • D3DTB0
    • D3DTB1
    • Q2HIY1
    • Q5VTF9
    • Q5VTG0
    • Q96SW9
    • Q9P251

    Protein attributes for MARK1 Gene

    Size:
    795 amino acids
    Molecular mass:
    89003 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Phosphorylation of MAPT/tau by MARK1 could play a role in early steps of Alzheimer disease. Pathological aggregation of MAPT/tau to neurofibrillary tangles, filamentous structures consisting of paired helical filaments (PHFs), is one of the hallmarks of Alzheimer disease. Hyperphosphorylation by MARK1 could be the initial step for this abnormal aggregation of tau in Alzheimer disease and animal models of tauopathy (PubMed:11089574).
    SequenceCaution:
    • Sequence=BAA96001.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55152.1; Type=Frameshift; Positions=763; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MARK1 Gene

    Alternative splice isoforms for MARK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARK1 Gene

Proteomics data for MARK1 Gene at MOPED

Post-translational modifications for MARK1 Gene

  • Phosphorylation at Thr-613 by PRKCZ/aPKC in polarized epithelial cells inhibits the kinase activity (By similarity). Phosphorylated at Thr-215 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-215 by TAOK1 activates the kinase activity, leading to phosphorylation and detachment of MAPT/TAU from microtubules. Phosphorylation at Ser-219 by GSK3-beta (GSK3B) inhibits the kinase activity.
  • Ubiquitination at Lys783
  • Modification sites at PhosphoSitePlus

Other Protein References for MARK1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MARK1 (MARK1)

Domains for MARK1 Gene

Gene Families for MARK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P0L2

UniProtKB/Swiss-Prot:

MARK1_HUMAN :
  • Q9P0L2
Domain:
  • The UBA domain does not seem to bind ubiquitin and ubiquitin-like and might play a role in regulating the enzyme conformation and localization. Activation of the kinase activity following phosphorylation at Thr-208 is accompanied by a conformational change that alters the orientation of the UBA domain with respect to the catalytic domain (By similarity).
  • The KA1 domain mediates binding to phospholipids and targeting to membranes. Binds phosphatidic acid (PA), phosphatidylserine (PtdSer) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).
  • Contains 1 KA1 (kinase-associated) domain.
  • Contains 1 protein kinase domain.
  • Contains 1 UBA domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with MARK1: view

Function for MARK1 Gene

Molecular function for MARK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot CatalyticActivity: ATP + [tau protein] = ADP + [tau protein] phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by phosphorylation at Ser-219 (By similarity). Activated by phosphorylation on Thr-215.
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).

Enzyme Numbers (IUBMB) for MARK1 Gene

Gene Ontology (GO) - Molecular Function for MARK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 14976552
GO:0001786 phosphatidylserine binding IDA 21145462
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 14976552
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with MARK1: view

Phenotypes for MARK1 Gene

GenomeRNAi human phenotypes for MARK1:
genes like me logo Genes that share phenotypes with MARK1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MARK1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MARK1 Gene

Localization for MARK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARK1 Gene

Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Appears to localize to an intracellular network. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MARK1 Gene COMPARTMENTS Subcellular localization image for MARK1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for MARK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005856 cytoskeleton ISS --
GO:0005886 plasma membrane IDA 21145462
GO:0015630 microtubule cytoskeleton TAS 9108484
genes like me logo Genes that share ontologies with MARK1: view

Pathways for MARK1 Gene

genes like me logo Genes that share pathways with MARK1: view

Pathways by source for MARK1 Gene

2 Cell Signaling Technology pathways for MARK1 Gene
1 BioSystems pathway for MARK1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MARK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization --
GO:0001764 neuron migration ISS --
GO:0006468 protein phosphorylation IDA 14976552
GO:0007010 cytoskeleton organization ISS --
GO:0016055 Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with MARK1: view

Compounds for MARK1 Gene

(3) HMDB Compounds for MARK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with MARK1: view

Transcripts for MARK1 Gene

Unigene Clusters for MARK1 Gene

MAP/microtubule affinity-regulating kinase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MARK1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARK1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c
SP1: -
SP2: - - -
SP3:
SP4:

Relevant External Links for MARK1 Gene

GeneLoc Exon Structure for
MARK1
ECgene alternative splicing isoforms for
MARK1

Expression for MARK1 Gene

mRNA expression in normal human tissues for MARK1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MARK1 Gene

SOURCE GeneReport for Unigene cluster for MARK1 Gene Hs.497806

mRNA Expression by UniProt/SwissProt for MARK1 Gene

Q9P0L2-MARK1_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney.
genes like me logo Genes that share expressions with MARK1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MARK1 Gene

Orthologs for MARK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MARK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARK1 35
  • 99.62 (n)
  • 99.37 (a)
MARK1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 95 (a)
OneToMany
MARK1 35
  • 92.2 (n)
  • 97.11 (a)
MARK1 36
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MARK1 35
  • 93.46 (n)
  • 97.56 (a)
MARK1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mark1 35
  • 87 (n)
  • 94.34 (a)
Mark1 16
Mark1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MARK1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MARK1 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mark1 35
  • 87.6 (n)
  • 94.58 (a)
chicken
(Gallus gallus)
Aves MARK1 35
  • 84.21 (n)
  • 92.32 (a)
MARK1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MARK1 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mark1 35
  • 76.36 (n)
  • 88.87 (a)
zebrafish
(Danio rerio)
Actinopterygii mark1 35
  • 71.05 (n)
  • 83.98 (a)
mark1 36
  • 90 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta par-1 36
  • 37 (a)
OneToMany
KP78a 37
  • 60 (a)
KP78b 37
  • 46 (a)
CG3105 37
  • 30 (a)
CG15072 37
  • 48 (a)
par-1 37
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea par-1 36
  • 36 (a)
OneToMany
R02C2.1 37
  • 33 (a)
kin-29 37
  • 42 (a)
DC2.7a 37
  • 28 (a)
F23C8.8 37
  • 31 (a)
Y38H8A.4 37
  • 33 (a)
B0511.4 37
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for MARK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARK1 Gene

ENSEMBL:
Gene Tree for MARK1 (if available)
TreeFam:
Gene Tree for MARK1 (if available)

Paralogs for MARK1 Gene

Paralogs for MARK1 Gene

Pseudogenes.org Pseudogenes for MARK1 Gene

genes like me logo Genes that share paralogs with MARK1: view

Variants for MARK1 Gene

Sequence variations from dbSNP and Humsavar for MARK1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs769006 -- 220,532,382(+) ACATA(G/T)CATCT intron-variant
rs1073460 -- 220,553,477(-) ctaca(C/T)tgatg intron-variant
rs1073461 -- 220,553,458(-) aacaa(A/G)tatgg intron-variant
rs1193030 -- 220,621,621(+) GCCTC(A/G)TAGAT intron-variant
rs1193031 -- 220,622,955(+) AATTC(C/T)TTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARK1 Gene

Variant ID Type Subtype PubMed ID
nsv508061 CNV Loss 20534489
esv2470287 CNV Insertion 19546169

Relevant External Links for MARK1 Gene

HapMap Linkage Disequilibrium report
MARK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARK1 Gene

Disorders for MARK1 Gene

UniProtKB/Swiss-Prot

MARK1_HUMAN
  • Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.

Relevant External Links for MARK1

Genetic Association Database (GAD)
MARK1
Human Genome Epidemiology (HuGE) Navigator
MARK1
genes like me logo Genes that share disorders with MARK1: view

Publications for MARK1 Gene

  1. Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism. (PMID: 18492799) Maussion G. … Simonneau M. (Hum. Mol. Genet. 2008) 3 4 23 48
  2. MARK - a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. (PMID: 9108484) Drewes G. … Mandelkow E. (Cell 1997) 2 3 4
  3. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids. (PMID: 21145462) Moravcevic K. … Lemmon M.A. (Cell 2010) 3 4

Products for MARK1 Gene

Sources for MARK1 Gene

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