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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MARK1 Gene

protein-coding GIFtS: 61
GCID: GC01P220701

MAP/microtubule affinity-regulating kinase 1

Explore 7 diseases affiliated with
MARK1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
MAP/Microtubule Affinity-Regulating Kinase 1¹ ² ³		EC 2.7.11.1³ ⁸
MARK¹ ² ³		KIAA1477³ ⁵
Par-1c² ³		Serine/Threonine-Protein Kinase MARK1²
Par1c² ³		EC 2.7.11.26³
PAR1 Homolog C² ³		EC 2.7.11⁸

External Ids:	HGNC: 6896¹	Entrez Gene: 4139²	Ensembl: ENSG00000116141⁷	OMIM: 606511⁵	UniProtKB: Q9P0L2³

Export aliases for MARK1 gene to outside databases

Previous GC identifers: GC01P219297 GC01P216545 GC01P217248 GC01P217758 GC01P217757 GC01P217089 GC01P218768 GC01P191375

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MARK1_HUMAN, Q9P0L2

Function: Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates

DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2,

MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the

regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics,

possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway,

probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3)

Gene Wiki entry for MARK1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167186.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MARK1 gene promoter:
AP-1 ATF-2 p300 MyoD IRF-1 MEF-2A ARP-1 c-Jun aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MARK1 promoter sequence

Search SABiosciences Chromatin IP Primers for MARK1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARK1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41 Ensembl cytogenetic band: 1q41 HGNC cytogenetic band: 1q41

MARK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARK1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P220701: view genomic region (about GC identifiers)

Start:	220,701,568 bp from pter	End:	220,837,803 bp from pter
Size:	136,236 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MARK1_HUMAN, Q9P0L2 (See protein sequence)

Recommended Name: Serine/threonine-protein kinase MARK1

Size: 795 amino acids; 89003 Da

Cofactor: Magnesium (By similarity)

Subcellular location: Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton (By similarity). Note=Appears

to localize to an intracellular network (By similarity)

Miscellaneous: Phosphorylation of MAPT/tau by MARK1 could play a role in early steps of Alzheimer disease. Pathological

aggregation of MAPT/tau to neurofibrillary tangles, filamentous structures consisting of paired helical filaments

(PHFs), is one of the hallmarks of Alzheimer disease. Hyperphosphorylation by MARK1 could be the initial step for this

abnormal aggregation of tau in Alzheimer disease and animal models of tauopathy (PubMed:11089574)

Sequence caution: Sequence=BAA96001.1; Type=Erroneous initiation; Sequence=BAB55152.1; Type=Frameshift; Positions=763;

2 PDB 3D structures from and Proteopedia for MARK1:

2HAK (3D)

3OSE (3D)

Secondary accessions: D3DTB0 D3DTB1 Q2HIY1 Q5VTF9 Q5VTG0 Q96SW9 Q9P251

Alternative splicing: 3 isoforms: Q9P0L2-1 Q9P0L2-2 Q9P0L2-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MARK1: NX_Q9P0L2

Post-translational modifications:

Phosphorylation at Thr-613 by PRKCZ/aPKC in polarized epithelial cells inhibits the kinase activity (By similarity).

Phosphorylated at Thr-215 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.

Phosphorylation at Thr-215 by TAOK1 activates the kinase activity, leading to phosphorylation and detachment of

MAPT/TAU from microtubules. Phosphorylation at Ser-219 by GSK3-beta (GSK3B) inhibits the kinase activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9P0L2

4/27 DME Specific Peptides for MARK1 (Q9P0L2) (see all 27)

FRQIVSA

FAKVKLA

EYASGGE

LVAHGRM

MARK1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_061120.3

ENSEMBL proteins:

ENSP00000355885 ENSP00000355884 ENSP00000386017

Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant MARK1 Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for MARK1
	GenScript Custom Purified and Recombinant Proteins Services for MARK1
	Novus Biologicals MARK1 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MARK1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	ISS	--
GO:0005856	cytoskeleton	ISS	--
GO:0005886	plasma membrane	IDA	--
GO:0015630	microtubule cytoskeleton	TAS	9108484

MARK1 for ontologies About GeneDecksing

MARK1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Cell Signaling Technology (CST) Antibodies for MARK1
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	GenScript Custom Superior Antibodies Services for MARK1
	Novus Biologicals MARK1 Antibodies
	Abcam antibodies for MARK1
	Uscn Antibodies for MARK1
	ThermoFisher Antibodies for MARK1

Assay Products for MARK1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MARK1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MARK1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MARK1 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR017441 Protein_kinase_ATP_BS

IPR001772 KA1_dom

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

Graphical View of Domain Structure for InterPro Entry Q9P0L2

ProtoNet protein and cluster: Q9P0L2

2 Blocks protein families:

IPB000449 Ubiquitin-associated domain

IPB001772 Kinase-associated

UniProtKB/Swiss-Prot: MARK1_HUMAN, Q9P0L2

Domain: The UBA domain does not seem to bind ubiquitin and ubiquitin-like and might play a role in regulating the

enzyme conformation and localization. Activation of the kinase activity following phosphorylation at Thr-208 is

accompanied by a conformational change that alters the orientation of the UBA domain with respect to the catalytic

domain (By similarity)

Domain: The KA1 domain mediates binding to phospholipids and targeting to membranes. Binds phosphatidic acid (PA),

phosphatidylserine (PtdSer) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)

Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily

Similarity: Contains 1 KA1 (kinase-associated) domain

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 UBA domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MARK1_HUMAN, Q9P0L2

Function: Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates

DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2,

MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the

regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics,

possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway,

probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3)

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Catalytic activity: ATP + [tau protein] = ADP + [tau protein] phosphate

Enzyme regulation: Inhibited by phosphorylation at Ser-219 (By similarity). Activated by phosphorylation on Thr-215

Enzyme Numbers (IUBMB): EC 2.7.11.1¹ ² EC 2.7.11² EC 2.7.11.26¹

miRNA Products:		OriGene 3'-UTR Clone: MARK1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARK1
		8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate MARK1 (see all 62):
		hsa-miR-140-5p hsa-miR-549 hsa-miR-3607-3p hsa-miR-300 hsa-miR-513a-5p hsa-miR-200a hsa-miR-4305 hsa-miR-25

		SwitchGear 3'UTR luciferase reporter plasmid: MARK1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MARK1 (see all 6) OriGene siRNA: MARK1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARK1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MARK1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MARK1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MARK1 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MARK1 (NM_018650)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARK1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARK1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MARK1
		Search LifeMap BioReagents cell lines for MARK1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARK1

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IDA	14976552
GO:0001786	phosphatidylserine binding	IDA	--
GO:0004672	protein kinase activity	--	--
GO:0004674	protein serine/threonine kinase activity	IDA	14976552
GO:0005524	ATP binding	IDA	14976552

MARK1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MARK1:

Decreased viability with pacli

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytoskeletal Signaling

Cytoskeletal Signaling

1.00

Glucose / Energy Metabolism

Glucose / Energy Metabolism

1.00

Cytoskeleton remodeling Neurofilaments

Cytoplasmic microtubules

0.32

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for MARK1

Cytoplasmic microtubules

2 Cell Signaling Technology (CST) Pathways for MARK1

	Cytoskeletal Signaling
	Glucose / Energy Metabolism

MARK1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MARK1

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/17 Interacting proteins for MARK1 (Q9P0L2^{2, 3} ENSP00000355884⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SFN	P31947²^,³	MINT-3975066 I2D: score=2
USP21	Q9UK80³, ENSP00000289865⁴	I2D: score=2 STRING: ENSP00000289865
YWHAE	P62258³, ENSP00000264335⁴	I2D: score=2 STRING: ENSP00000264335
STK11	Q15831³, ENSP00000324856⁴	I2D: score=1 STRING: ENSP00000324856
MARK2	Q7KZI7³, ENSP00000389184⁴	I2D: score=2 STRING: ENSP00000389184

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000226	microtubule cytoskeleton organization	IEA	--
GO:0001764	neuron migration	ISS	--
GO:0006468	protein phosphorylation	IDA	14976552
GO:0007010	cytoskeleton organization	ISS	--
GO:0007243	intracellular protein kinase cascade	IDA	14976552

MARK1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MARK1

3 HMDB Compounds for MARK1 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

Search CenterWatch for drugs/clinical trials and news about MARK1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MARK1 gene:

NM_018650.3

Unigene Cluster for MARK1:

MAP/microtubule affinity-regulating kinase 1

Hs.497806 [show with all ESTs]

Unigene Representative Sequence: NM_018650

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000366918(uc001hmm.4) ENST00000472121(uc001hml.3) ENST00000366917

ENST00000485104 ENST00000402574(uc001hmn.4 uc009xdw.3 uc010pun.2)

miRNA Products:		OriGene 3'-UTR Clone: MARK1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARK1
		8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate MARK1 (see all 62):
		hsa-miR-140-5p hsa-miR-549 hsa-miR-3607-3p hsa-miR-300 hsa-miR-513a-5p hsa-miR-200a hsa-miR-4305 hsa-miR-25

		SwitchGear 3'UTR luciferase reporter plasmid: MARK1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MARK1 (see all 6) OriGene siRNA: MARK1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARK1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MARK1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MARK1 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MARK1 (NM_018650)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARK1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARK1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MARK1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MARK1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARK1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARK1

Additional cDNA sequence:

AB040910.1 AF154845.1 AK027493.1 AK098103.1 AK295506.1 AK314614.1 AL512724.1 BC068608.1

BC113869.1 BC114478.1

7 DOTS entries:

DT.112495 DT.95164015 DT.102836206 DT.100752193 DT.121445764 DT.75117389 DT.121290240

24/77 AceView cDNA sequences (see all 77):

AW079096 N99718 AI740480 F09467 CK904215 BG680272 AW664146 AW304703

AB040910 AL512724 CB216691 BM695949 R52660 AI864143 BC068608 CK299559

BM021078 AK098103 BQ890987 NM_018650 CK904214 AF154845 AW960038 CB156257

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for MARK1 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17	^	18	^	19a	·	19b	·	19c
SP1:											-
SP2:											-				-																										-
SP3:
SP4:

ECgene alternative splicing isoforms for MARK1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MARK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTGCTTAAA

About this image

MARK1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Head Mesenchyme

Branchial Arch 1

Cranial Neural Crest Cells

Neural Crest

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MARK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MARK1

SOURCE GeneReport for Unigene cluster: Hs.497806

UniProtKB/Swiss-Prot: MARK1_HUMAN, Q9P0L2

Tissue specificity: Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney

SABiosciences Expression via Pathway-Focused PCR Array including MARK1:

Notch Signaling Targets in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MARK1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARK1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARK1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARK1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MARK1 gene from 6/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MARK1¹	MAP/microtubule affinity-regulating kinase 1	84.3(n) 92.32(a)		421342 XM_419403.3 XP_419403.2
lizard (Anolis carolinensis)	Reptilia	MARK1⁶	--	91(a)	1 ↔ 1	1(243469731-243520087)
zebrafish (Danio rerio)	Actinopterygii	mark1¹	MAP/microtubule affinity-regulating kinase 1	71.35(n) 84.24(a)		100003170 NM_001114476.1 NP_001107948.1
fruit fly (Drosophila melanogaster)	Insecta	KP78a³	protein amino acid phosphorylation protein kinase	60(a) (best of 5)		86E4 --
worm (Caenorhabditis elegans)	Secernentea	kin-29³	serine/threonine-protein kinase	42(a) (best of 6)		X(2880113-2887689) --
rice (Oryza sativa)	Liliopsida	--	CAMK_KIN1/SNF1/Nim1_like_AMPKh.1 - CAMK includes c...	23(a)	possible ortholog	7(5101510-5106299)

ENSEMBL Gene Tree for MARK1 (if available)
TreeFam Gene Tree for MARK1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MARK1 gene

BRSK1² NUAK1² BRSK2² SIK3² SNRK² SIK2² NUAK2² MARK2²

NIM1² SIK1² MARK4² MARK3²

18/57 SIMAP similar genes for MARK1 using alignment to 2 protein entries: MARK1_HUMAN (see all proteins) (see all similar genes):

DKFZp547M202 MARK4 KIAA0999 MARK2 Par1b SIK3

MARK3 PRKAA2 NUAK1 PRKAA1 NUAK2 PRKACA

TSSK3 PRKACB AURKC CAMK1G CAMK2B KIN27

MARK1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for MARK1
PGOHUM00000261259

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7516393^1,2	C,F,H,	--	220699644(+)	`CCACGA/TTTATA`	1	--	us2k¹		5		NS EA NA	540
rs142476904^1,2		--	220699927(+)	`AATGTA/GTCTTG`	1	--	us2k¹		0	--	--	--	--
rs61830192^1,2		--	220699961(+)	`GGCACG/ATAAAT`	1	--	us2k¹		1		NA	2
rs190915724^1,2		--	220699975(+)	`TGACAG/TTCTCA`	1	--	us2k¹		0	--	--	--	--
rs3820346^1,2	C,	--	220700071(+)	`TTGTTT/GTTTTT`	1	--	us2k¹		1		NA	2
rs201960179^1,2	C	--	220700085(-)	`CAAATA/GANNNN`	1	--	us2k¹		0	--	--	--	--
rs183408349^1,2		--	220700235(+)	`TTGGAC/TCCATG`	1	--	us2k¹		0	--	--	--	--
rs12068533^1,2	C,H	--	220700268(+)	`TTTCAG/AAAACA`	1	--	us2k¹ tfbs³		6		NS EA NA	420
rs187445060^1,2		--	220700302(+)	`ACCATC/TTGGTT`	1	--	us2k¹		0	--	--	--	--
rs17007885^1,2	C,F,H,	--	220700353(+)	`GAGAAA/TTTTCC`	1	--	us2k¹		13		NA NS EA	782

HapMap Linkage Disequilibrium report for MARK1 (220701568 - 220837803 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MARK1
1 CNV: 97638

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MARK1 for disorders About GeneDecksing

OMIM gene information: 606511 OMIM disorders: --

UniProtKB/Swiss-Prot: MARK1_HUMAN, Q9P0L2

Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in

the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites

7 diseases for MARK1: About MalaCards

peutz-jeghers syndrome ocular hypertension tauopathy hypertension

alzheimer's disease malaria neuronitis

Human Genome Epidemiology (HuGE) Navigator: MARK1 (2 documents)

Export disorders for MARK1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MARK1 gene, integrated from 9 sources (see all 55):
(articles sorted by number of sources associating them with MARK1)

Utopia: connect your pdf to the dynamic
world of online information

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. (PubMed id 9108484)^{1, 2, 3} Drewes G....Mandelkow E. (1997)
Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism. (PubMed id 18492799)^{1, 2, 9} Maussion G....Simonneau M. (2008)
Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2. (PubMed id 16803889)^{1, 2} Marx A.... Mandelkow E. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)^{1, 2} Lizcano J.M....Alessi D.R. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)^{1, 2} Nagase T.... Ohara O. (2000)
Systematic survey of deubiquitinase localization ident ifies USP21 as a regulator of centrosome- and microtubule-associated functions. (PubMed id 22298430)¹ Urbe S....Clague M.J. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4139	HGNC: 6896	AceView: MARK1	Ensembl:ENSG00000116141	euGenes: HUgn4139
ECgene: MARK1	H-InvDB: MARK1

(According to HUGE)
About This Section

HUGE: KIAA1477

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MARK1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MARK1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MARK1 gene:
Search GeneIP for patents involving MARK1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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