Aliases for MARK1 Gene
External Ids for MARK1 Gene
Previous GeneCards Identifiers for MARK1 Gene
GeneCards Summary for MARK1 Gene
MARK1 (MAP/Microtubule Affinity-Regulating Kinase 1) is a Protein Coding gene. Diseases associated with MARK1 include tauopathy and alzheimer disease. Among its related pathways are Cytoskeletal Signaling and Glucose / Energy Metabolism. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MARK4.
UniProtKB/Swiss-Prot for MARK1 Gene
Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).