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MARCO Gene

protein-coding   GIFtS: 61
GCID: GC02P119794

Macrophage Receptor With Collagenous Structure

  See MARCO-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Macrophage Receptor With Collagenous Structure1 2 3     Scavenger Receptor Class A1
Scavenger Receptor Class A Member 22 3     Macrophage Receptor MARCO2
SCARA22 3     Scavenger Receptor Class A, Member 22
Member 21     

External Ids:    HGNC: 68951   Entrez Gene: 86852   Ensembl: ENSG000000191697   OMIM: 6048705   UniProtKB: Q9UEW33   

Export aliases for MARCO gene to outside databases

Previous GC identifers: GC02P116905 GC02P117620 GC02P119606 GC02P119415 GC02P112024


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MARCO Gene:
The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate
antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an
extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and
transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The
protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide
chains. (provided by RefSeq, Jul 2008)

GeneCards Summary for MARCO Gene:
MARCO (macrophage receptor with collagenous structure) is a protein-coding gene. Diseases associated with MARCO include spondylarthropathy. GO annotations related to this gene include transmembrane signaling receptor activity and signaling pattern recognition receptor activity. An important paralog of this gene is SCARA5.

UniProtKB/Swiss-Prot: MARCO_HUMAN, Q9UEW3
Function: Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria

Gene Wiki entry for MARCO Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the MARCO gene promoter:
         Pax-2   Pax-2a   CUTL1   MEF-2A   POU2F1   POU2F1a   Sox9   ARP-1   ZID   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMARCO promoter sequence
   Search Chromatin IP Primers for MARCO

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARCO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14.2   Ensembl cytogenetic band:  2q14.2   HGNC cytogenetic band: 2q14.2

MARCO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCO gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P119794:  view genomic region     (about GC identifiers)

Start:
119,699,742 bp from pter      End:
119,752,236 bp from pter
Size:
52,495 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MARCO_HUMAN, Q9UEW3 (See protein sequence)
Recommended Name: Macrophage receptor MARCO  
Size: 520 amino acids; 52658 Da
Subunit: Homotrimer. Trimers may assemble in larger oligomers thus resulting in the creation of a large surface
capable of interacting with very large ligands (By similarity)
Secondary accessions: Q9Y5S3

Explore the universe of human proteins at neXtProt for MARCO: NX_Q9UEW3

Explore proteomics data for MARCO at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn83, Asn136
  • Modification sites at PhosphoSitePlus

  • See MARCO Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006761.1  
    ENSEMBL proteins: 
     ENSP00000318916   ENSP00000409192   ENSP00000441769  
    Reactome Protein details: Q9UEW3

    MARCO Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for MARCO
    Sino Biological Cell Lysate for MARCO
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MARCO

     
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    antibodies-online proteins for MARCO (2 products) 

     
    antibodies-online peptides for MARCO

    MARCO Antibody Products:

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    antibodies-online antibodies for MARCO (55 products) 

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    Cloud-Clone Corp. CLIAs for MARCO
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    antibodies-online kits for MARCO (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001190 SRCR
     IPR017448 Srcr_rcpt-rel
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry Q9UEW3

    ProtoNet protein and cluster: Q9UEW3

    3 Blocks protein domains:
    IPB001190 Speract/scavenger receptor
    IPB008160 Collagen triple helix repeat
    IPB008161 Collagen helix repeat


    UniProtKB/Swiss-Prot: MARCO_HUMAN, Q9UEW3
    Similarity: Contains 1 collagen-like domain
    Similarity: Contains 1 SRCR domain


    Find genes that share domains with MARCO           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARCO_HUMAN, Q9UEW3
    Function: Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria

         Genatlas biochemistry entry for MARCO:
    macrophage receptor with collagenous structure,constitutively expressed in macrophages of spleen and lymph nodes
    and in other tissues following systemic,bacterial infection

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS10331948
    GO:0005044scavenger receptor activity IEA--
    GO:0008329signaling pattern recognition receptor activity TAS10331948
         
    Find genes that share ontologies with MARCO           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Marco):
     cellular  hematopoietic system  immune system  mortality/aging 

    Find genes that share phenotypes with MARCO           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MARCO: Marcotm1Spt Marcotm1Lk

       genOway: Develop your customized and physiologically relevant rodent model for MARCO

    miRNA
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    Block miRNA regulation of human, mouse, rat MARCO using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat MARCO

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    GenScript: all cDNA clones in your preferred vector: MARCO (NM_006770)
    Sino Biological Human cDNA Clone for MARCO
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCO

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCO


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MARCO_HUMAN, Q9UEW3: Membrane; Single-pass type II membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular3
    cytosol2
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005581collagen IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9468508
    GO:0016020membrane ----
    GO:0030666endocytic vesicle membrane TAS--

    Find genes that share ontologies with MARCO           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MARCO About    
    See pathways by source

    SuperPathContained pathways About
    1Binding and Uptake of Ligands by Scavenger Receptors
    Binding and Uptake of Ligands by Scavenger Receptors0.53
    Scavenging by Class A Receptors0.00
    2Phagosome
    Phagosome
    3Phagocytosis of Microbes
    Phagocytosis of Microbes
    4A-beta Uptake and Degradation
    A-beta Uptake and Degradation


    Find genes that share SuperPaths with MARCO           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for MARCO
        A-beta Uptake & Degradation

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MARCO
        Phagocytosis of Microbes


    1 Reactome Pathway for MARCO
        Scavenging by Class A Receptors


    1 Kegg Pathway  (Kegg details for MARCO):
        Phagosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MARCO
    Interactions:

        GeneGlobe Interaction Network for MARCO

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for MARCO (Q9UEW32, 3 ENSP000003189164) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SCGB3A1Q96QR13, ENSP000002926414I2D: score=2 STRING: ENSP00000292641
    SCGB3A2Q96PL13, ENSP000002966944I2D: score=2 STRING: ENSP00000296694
    --Q777G92MINT-6769951
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002221pattern recognition receptor signaling pathway TAS10331948
    GO:0006897endocytosis ----
    GO:0007166cell surface receptor signaling pathway TAS9468508
    GO:0043277apoptotic cell clearance IEA--
    GO:0045087innate immune response IEA--

    Find genes that share ontologies with MARCO           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MARCO

    2 Novoseek inferred chemical compound relationships for MARCO gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inosine monophosphate 51.9 1 16524885 (1)
    oligonucleotide 41 1 12960310 (1)



    Find genes that share compounds with MARCO           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MARCO gene: 
    NM_006770.3  

    Unigene Cluster for MARCO:

    Macrophage receptor with collagenous structure
    Hs.67726  [show with all ESTs]
    Unigene Representative Sequence: BC016004
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327097(uc002tln.1) ENST00000412481 ENST00000494979 ENST00000541757(uc010yyf.1)

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MARCO
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    GenScript: all cDNA clones in your preferred vector: MARCO (NM_006770)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCO
    Primer
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    OriGene qPCR primer pairs and template standards for MARCO
    OriGene qSTAR qPCR primer pairs in human, mouse for MARCO
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARCO
      QuantiTect SYBR Green Assays in human, mouse, rat MARCO
      QuantiFast Probe-based Assays in human, mouse, rat MARCO

    Additional mRNA sequence: 

    AF035819.1 AK297030.1 AK301407.1 AK313139.1 BC016004.1 

    5 DOTS entries:

    DT.310288  DT.100792260  DT.95269837  DT.120953234  DT.100017222 

    Selected AceView cDNA sequences (see all 66):

    CB157677 CB529479 BI489833 CB123359 CD365798 CD364735 AL548211 BF222598 
    CR614449 AI133634 CR623903 CR603381 BM920246 CR595006 CR590986 AW770551 
    AI344291 BX364956 AA485867 BI823647 AA668948 BI519729 BI835415 AL572854 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MARCO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGCAGCCA
    MARCO Expression
    About this image


    MARCO expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Liver (Hepatobiliary System)
    MARCO Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MARCO Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.67726
        Custom PCR Arrays for MARCO
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCO

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MARCO gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Marco1 , 5 macrophage receptor with collagenous structure1, 5 74.64(n)1
    67.9(a)1
      1 (52.71 cM)5
    171671  NM_010766.21  NP_034896.11 
     1204745385 
    chicken
    (Gallus gallus)
    Aves MARCO1 macrophage receptor with collagenous structure 53.87(n)
    43.75(a)
      395488  NM_204736.1  NP_990067.1 
    lizard
    (Anolis carolinensis)
    Reptilia MARCO6
    macrophage receptor with collagenous structure
    35(a)
    1 ↔ 1
    GL343497.1(489398-518721)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004928721 macrophage receptor MARCO-like 58.38(n)
    50.89(a)
      100492872  XM_002944561.2  XP_002944607.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5715841 collagen alpha-1(XVII) chain-like 46.57(n)
    42.86(a)
      571584  XM_005169122.1  XP_005169179.1 


    ENSEMBL Gene Tree for MARCO (if available)
    TreeFam Gene Tree for MARCO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MARCO gene
    SCARA52  MSR12  
    18 SIMAP similar genes for MARCO using alignment to 4 protein entries:     MARCO_HUMAN (see all proteins):
    LGALS3BP    COL3A1    COL7A1    COL9A1    SFTPD    COL6A2
    COL21A1    COL1A2    COL22A1    COL5A3    COL9A2    GLDN
    COL16A1    COL2A1    COL4A2    COL4A4    COL4A5    COL8A2

    Find genes that share paralogs with MARCO           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MARCO (see all 1402)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1895521541,2
    --119697807(+) TGGAAA/GTTCAG 1 -- us2k10--------
    rs1818270021,2
    --119697817(+) GAGAAA/GTAAGT 1 -- us2k10--------
    rs1845796951,2
    --119697919(+) ACATCA/CACTAA 1 -- us2k10--------
    rs774030731,2
    --119697988(+) CCCCTC/TCCCAC 1 -- us2k10--------
    rs1157177341,2
    F--119697996(+) CACACC/TCATGA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1495626881,2
    --119698042(+) GAGAGA/CAGGGA 1 -- us2k10--------
    rs67484011,2
    C,F,A,H--119698057(+) TGCCAG/AGCTAA 1 -- us2k136Minor allele frequency- A:0.48NS EA NA WA CSA 3385
    rs729606271,2
    C,F--119698183(+) TCCAAC/TTTTCC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1125011801,2
    C--119698232(+) TCTGGC/TGGAAC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1483284481,2
    C--119698243(+) CAGTGA/GCTTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MARCO (119699742 - 119752236 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for MARCO:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660693CNV Deletion23128226
    esv2380956CNV Deletion18987734
    esv2544799CNV Deletion19546169
    esv2720622CNV Deletion23290073
    esv2720623CNV Deletion23290073
    nsv527208CNV Loss19592680
    nsv528763CNV Loss19592680
    nsv522323CNV Loss19592680
    nsv459119CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MARCO
    DNA2.0 Custom Variant and Variant Library Synthesis for MARCO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604870    OMIM disorders: --

    1 disease for MARCO:    
    About MalaCards
    spondylarthropathy


    Find genes that share disorders with MARCO           About GenesLikeMe

    Genetic Association Database (GAD): MARCO
    Human Genome Epidemiology (HuGE) Navigator: MARCO (71 documents)

    Export disorders for MARCO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MARCO gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with MARCO)
        Utopia: connect your pdf to the dynamic
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    1. Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor. (PubMed id 10331948)1, 2, 3, 9 Kangas M....Tryggvason K. (Genomics 1999)
    2. Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region. (PubMed id 9468508)1, 2, 3, 9 Elomaa O.... Tryggvason K. (J. Biol. Chem. 1998)
    3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages. (PubMed id 7867067)1, 3 Elomaa O....Tryggvason K. (Cell 1995)
    7. Expression of host defense scavenger receptors in spondylarthropathy. (PubMed id 11315932)1, 9 Seta N....Yu D.T. (Arthritis Rheum. 2001)
    8. Pivotal Advance: Expansion of small sputum macrophages in CF: failure to express MARCO and mannose receptors. (PubMed id 19403625)1, 9 Wright A.K....Ziegler-Heitbrock L. (J. Leukoc. Biol. 2009)
    9. Characterization of recombinant soluble macrophage scavenger receptor MARCO. (PubMed id 12097327)1, 9 Sankala M....Pikkarainen T. (J. Biol. Chem. 2002)
    10. Molecular characterization of a human scavenger receptor, human MARCO. (PubMed id 10651831)1, 9 Elshourbagy N.A....Lysko P.G. (Eur. J. Biochem. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8685 HGNC: 6895 AceView: MARCO Ensembl:ENSG00000019169 euGenes: HUgn8685
    ECgene: MARCO Kegg: 8685 H-InvDB: MARCO

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MARCO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MARCO gene:
    Search GeneIP for patents involving MARCO

    GeneCards and IP:
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