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Aliases for MARCO Gene

Aliases for MARCO Gene

  • Macrophage Receptor With Collagenous Structure 2 3 4
  • SCARA2 3 4
  • Scavenger Receptor Class A, Member 2 3
  • Scavenger Receptor Class A Member 2 4
  • Scavenger Receptor Class A 2
  • Macrophage Receptor MARCO 3
  • Member 2 2

External Ids for MARCO Gene

Previous GeneCards Identifiers for MARCO Gene

  • GC02P116905
  • GC02P117620
  • GC02P119606
  • GC02P119794
  • GC02P119415
  • GC02P112024

Summaries for MARCO Gene

Entrez Gene Summary for MARCO Gene

  • The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]

GeneCards Summary for MARCO Gene

MARCO (Macrophage Receptor With Collagenous Structure) is a Protein Coding gene. Diseases associated with MARCO include spondylarthropathy. Among its related pathways are A-beta Uptake and Degradation and Phagosome. GO annotations related to this gene include transmembrane signaling receptor activity and signaling pattern recognition receptor activity. An important paralog of this gene is SCARA5.

UniProtKB/Swiss-Prot for MARCO Gene

  • Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria

Gene Wiki entry for MARCO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCO Gene

Genomics for MARCO Gene

Regulatory Elements for MARCO Gene

Genomic Location for MARCO Gene

118,942,166 bp from pter
118,994,660 bp from pter
52,495 bases
Plus strand

Genomic View for MARCO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARCO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCO Gene

Proteins for MARCO Gene

  • Protein details for MARCO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Macrophage receptor MARCO
    Protein Accession:
    Secondary Accessions:
    • B4DW79
    • Q9Y5S3

    Protein attributes for MARCO Gene

    520 amino acids
    Molecular mass:
    52658 Da
    Quaternary structure:
    • Homotrimer. Trimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands (By similarity).

    Alternative splice isoforms for MARCO Gene


neXtProt entry for MARCO Gene

Proteomics data for MARCO Gene at MOPED

Post-translational modifications for MARCO Gene

  • Glycosylation at Asn83 and Asn136
  • Modification sites at PhosphoSitePlus

Other Protein References for MARCO Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MARCO Gene

Domains for MARCO Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 collagen-like domain.
  • Contains 1 collagen-like domain.
  • Contains 1 SRCR domain.
genes like me logo Genes that share domains with MARCO: view

No data available for Gene Families for MARCO Gene

Function for MARCO Gene

Molecular function for MARCO Gene

GENATLAS Biochemistry:
macrophage receptor with collagenous structure,constitutively expressed in macrophages of spleen and lymph nodes and in other tissues following systemic,bacterial infection
UniProtKB/Swiss-Prot Function:
Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria

Gene Ontology (GO) - Molecular Function for MARCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 10331948
GO:0005044 scavenger receptor activity IEA --
GO:0008329 signaling pattern recognition receptor activity TAS 10331948
genes like me logo Genes that share ontologies with MARCO: view
genes like me logo Genes that share phenotypes with MARCO: view

Animal Models for MARCO Gene

MGI Knock Outs for MARCO:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MARCO

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for MARCO Gene

Localization for MARCO Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCO Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for MARCO Gene COMPARTMENTS Subcellular localization image for MARCO gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytosol 2
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MARCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9468508
GO:0016020 membrane --
GO:0030666 endocytic vesicle membrane TAS --
genes like me logo Genes that share ontologies with MARCO: view

Pathways for MARCO Gene

genes like me logo Genes that share pathways with MARCO: view

Pathways by source for MARCO Gene

1 KEGG pathway for MARCO Gene
1 R&D Systems pathway for MARCO Gene

Interacting Proteins for MARCO Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9UEW3-MARCO_HUMAN ENSP00000318916 for MARCO Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for MARCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002221 pattern recognition receptor signaling pathway TAS 10331948
GO:0006897 endocytosis --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0007166 cell surface receptor signaling pathway TAS 9468508
GO:0043277 apoptotic cell clearance IEA --
genes like me logo Genes that share ontologies with MARCO: view

Drugs for MARCO Gene

(2) Novoseek inferred chemical compound relationships for MARCO Gene

Compound -log(P) Hits PubMed IDs
inosine monophosphate 51.9 1
oligonucleotide 41 1
genes like me logo Genes that share compounds with MARCO: view

Transcripts for MARCO Gene

Unigene Clusters for MARCO Gene

Macrophage receptor with collagenous structure:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MARCO

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCO Gene

No ASD Table

Relevant External Links for MARCO Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MARCO Gene

mRNA expression in normal human tissues for MARCO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MARCO Gene

This gene is overexpressed in Lung (9.0), Whole Blood (6.8), Spleen (6.6), and Liver (4.1).

Protein differential expression in normal tissues for MARCO Gene

This gene is overexpressed in Urine (34.9), Plasma (10.3), and Lymph node (6.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MARCO Gene

SOURCE GeneReport for Unigene cluster for MARCO Gene Hs.67726

genes like me logo Genes that share expressions with MARCO: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for MARCO Gene

Orthologs for MARCO Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCO Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia MARCO 35
  • 79.87 (n)
  • 72.81 (a)
  • 66 (a)
(Mus musculus)
Mammalia Marco 35
  • 74.64 (n)
  • 67.9 (a)
Marco 16
Marco 36
  • 62 (a)
(Pan troglodytes)
Mammalia MARCO 35
  • 98.46 (n)
  • 97.88 (a)
  • 91 (a)
(Rattus norvegicus)
Mammalia Marco 35
  • 74.32 (n)
  • 67.51 (a)
(Bos Taurus)
Mammalia MARCO 36
  • 54 (a)
(Monodelphis domestica)
Mammalia MARCO 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia MARCO 36
  • 46 (a)
(Gallus gallus)
Aves MARCO 35
  • 53.87 (n)
  • 43.75 (a)
  • 37 (a)
(Anolis carolinensis)
Reptilia MARCO 36
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492872 35
  • 58.38 (n)
  • 50.89 (a)
(Danio rerio)
Actinopterygii LOC571584 35
  • 46.57 (n)
  • 42.86 (a)
marco 36
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for MARCO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARCO Gene

Gene Tree for MARCO (if available)
Gene Tree for MARCO (if available)

Paralogs for MARCO Gene

Paralogs for MARCO Gene

genes like me logo Genes that share paralogs with MARCO: view

Variants for MARCO Gene

Sequence variations from dbSNP and Humsavar for MARCO Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs767882 -- 118,984,970(+) AGTGC(A/G)TTGGC intron-variant
rs978102 -- 118,952,632(+) aagtc(A/G/T)tcgct intron-variant
rs979387 -- 118,989,926(+) CAGCA(A/G)GATGC intron-variant
rs980715 -- 118,960,150(+) ATAAA(A/G)CTTTT intron-variant
rs1073529 -- 118,947,403(+) actca(C/T)gggct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARCO Gene

Variant ID Type Subtype PubMed ID
nsv459119 CNV Gain 19166990
esv2380956 CNV Deletion 18987734
esv2720622 CNV Deletion 23290073
esv2544799 CNV Deletion 19546169
esv2660693 CNV Deletion 23128226
nsv522323 CNV Loss 19592680
esv2720623 CNV Deletion 23290073
nsv528763 CNV Loss 19592680
nsv527208 CNV Loss 19592680

Relevant External Links for MARCO Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCO Gene

Disorders for MARCO Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MARCO Gene in MalaCards »

(1) Disease for MARCO Gene

Relevant External Links for MARCO

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MARCO: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MARCO Gene

Publications for MARCO Gene

  1. Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor. (PMID: 10331948) Kangas M. … Tryggvason K. (Genomics 1999) 2 3 4 23
  2. Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region. (PMID: 9468508) Elomaa O. … Tryggvason K. (J. Biol. Chem. 1998) 2 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages. (PMID: 7867067) Elomaa O. … Tryggvason K. (Cell 1995) 2 3
  5. Pivotal Advance: Expansion of small sputum macrophages in CF: failure to express MARCO and mannose receptors. (PMID: 19403625) Wright A.K. … Ziegler-Heitbrock L. (J. Leukoc. Biol. 2009) 3 23

Products for MARCO Gene

Sources for MARCO Gene

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