Aliases for MARCO Gene
External Ids for MARCO Gene
Previous GeneCards Identifiers for MARCO Gene
The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]
GeneCards Summary for MARCO Gene
MARCO (Macrophage Receptor With Collagenous Structure) is a Protein Coding gene. Diseases associated with MARCO include Igg4-Related Disease and Mental Retardation, X-Linked, Snyder-Robinson Type. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and A-beta Pathways: Uptake and Degradation. GO annotations related to this gene include transmembrane signaling receptor activity and signaling pattern recognition receptor activity. An important paralog of this gene is MSR1.
UniProtKB/Swiss-Prot for MARCO Gene
Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.