Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MARCKSL1 Gene

Aliases for MARCKSL1 Gene

  • MARCKS-Like 1 2 3
  • MRP 3 4 6
  • MLP 3 4 6
  • Macrophage Myristoylated Alanine-Rich C Kinase Substrate 3 4
  • MARCKS-Like Protein 1 3 4
  • Mac-MARCKS 3 4
  • MACMARCKS 3 4
  • MARCKS-Related Protein 3
  • MARCKS-Like Protein 2
  • MLP1 3
  • F52 3

External Ids for MARCKSL1 Gene

Previous Symbols for MARCKSL1 Gene

  • MLP

Summaries for MARCKSL1 Gene

Entrez Gene Summary for MARCKSL1 Gene

  • This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012]

GeneCards Summary for MARCKSL1 Gene

MARCKSL1 (MARCKS-Like 1) is a Protein Coding gene. Diseases associated with MARCKSL1 include intermediate charcot-marie-tooth neuropathy and anencephaly. Among its related pathways are Fc gamma R-mediated phagocytosis and Leishmaniasis. GO annotations related to this gene include actin binding and calmodulin binding.

UniProtKB/Swiss-Prot for MARCKSL1 Gene

  • Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity).

Gene Wiki entry for MARCKSL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCKSL1 Gene

Genomics for MARCKSL1 Gene

Genomic Location for MARCKSL1 Gene

Start:
32,333,829 bp from pter
End:
32,336,379 bp from pter
Size:
2,551 bases
Orientation:
Minus strand

Genomic View for MARCKSL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARCKSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCKSL1 Gene

Regulatory Elements for MARCKSL1 Gene

Proteins for MARCKSL1 Gene

  • Protein details for MARCKSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49006-MRP_HUMAN
    Recommended name:
    MARCKS-related protein
    Protein Accession:
    P49006
    Secondary Accessions:
    • D3DPQ0
    • Q5TEE6
    • Q6NXS5

    Protein attributes for MARCKSL1 Gene

    Size:
    195 amino acids
    Molecular mass:
    19529 Da
    Quaternary structure:
    • Binds to filamentous actin (F-actin), but not to monomeric G-actin, independently of its phosphorylation status.

neXtProt entry for MARCKSL1 Gene

Proteomics data for MARCKSL1 Gene at MOPED

Post-translational modifications for MARCKSL1 Gene

  • Phosphorylation at Ser-120 and Thr-178 are non-redundantly catalyzed by MAPK8 in vivo. Phosphorylation at Thr-148 is preferentially catalyzed by MAPK8 in vivo, but this modification can also be catalyzed by other kinases in the absence of MAPK8 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys99, Lys106, and Lys110

Other Protein References for MARCKSL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MARCKSL1 Gene

Domains for MARCKSL1 Gene

Protein Domains for MARCKSL1 Gene

Suggested Antigen Peptide Sequences for MARCKSL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49006

UniProtKB/Swiss-Prot:

MRP_HUMAN
Family:
  • Belongs to the MARCKS family.:
    • P49006
genes like me logo Genes that share domains with MARCKSL1: view

No data available for Gene Families for MARCKSL1 Gene

Function for MARCKSL1 Gene

Molecular function for MARCKSL1 Gene

UniProtKB/Swiss-Prot Function: Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity).

Gene Ontology (GO) - Molecular Function for MARCKSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with MARCKSL1: view
genes like me logo Genes that share phenotypes with MARCKSL1: view

Animal Models for MARCKSL1 Gene

MGI Knock Outs for MARCKSL1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MARCKSL1 Gene

Localization for MARCKSL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCKSL1 Gene

Cytoplasm. Cell membrane. Note=Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the effector domain with membranes may be regulated by Ca(2+)/calmodulin (By similarity). In prostate cancers, detected in the cytoplasm and associated with apical or basal membranes (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MARCKSL1 Gene COMPARTMENTS Subcellular localization image for MARCKSL1 gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytoskeleton 2
cytosol 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MARCKSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IDA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with MARCKSL1: view

Pathways for MARCKSL1 Gene

genes like me logo Genes that share pathways with MARCKSL1: view

Pathways by source for MARCKSL1 Gene

2 KEGG pathways for MARCKSL1 Gene

Interacting Proteins for MARCKSL1 Gene

Gene Ontology (GO) - Biological Process for MARCKSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with MARCKSL1: view

Compounds for MARCKSL1 Gene

(9) Novoseek inferred chemical compound relationships for MARCKSL1 Gene

Compound -log(P) Hits PubMed IDs
phorbol 40.8 1
phospholipid 38 8
calcitriol 26.5 1
lipid 25.7 7
retinoic acid 8.67 1
genes like me logo Genes that share compounds with MARCKSL1: view

Transcripts for MARCKSL1 Gene

mRNA/cDNA for MARCKSL1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(803) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MARCKSL1 Gene

MARCKS-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MARCKSL1 Gene

No ASD Table

Relevant External Links for MARCKSL1 Gene

GeneLoc Exon Structure for
MARCKSL1
ECgene alternative splicing isoforms for
MARCKSL1

Expression for MARCKSL1 Gene

mRNA expression in normal human tissues for MARCKSL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MARCKSL1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (7.5) and Brain - Substantia nigra (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MARCKSL1 Gene

SOURCE GeneReport for Unigene cluster for MARCKSL1 Gene Hs.75061

genes like me logo Genes that share expressions with MARCKSL1: view

No data available for mRNA Expression by UniProt/SwissProt for MARCKSL1 Gene

Orthologs for MARCKSL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCKSL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARCKSL1 35
  • 100 (n)
  • 100 (a)
MARCKSL1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MARCKSL1 35
  • 93.81 (n)
  • 94.85 (a)
MARCKSL1 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MARCKSL1 35
  • 95.02 (n)
  • 95.36 (a)
MARCKSL1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Marcksl1 35
  • 93.16 (n)
  • 95.9 (a)
Marcksl1 16
Marcksl1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MARCKSL1 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Marcksl1 35
  • 92.53 (n)
  • 94.79 (a)
chicken
(Gallus gallus)
Aves MARCKSL1 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MARCKSL1 36
  • 35 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii marcksl1a 36
  • 34 (a)
OneToMany
marcksl1b 36
  • 43 (a)
OneToMany
Species with no ortholog for MARCKSL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARCKSL1 Gene

ENSEMBL:
Gene Tree for MARCKSL1 (if available)
TreeFam:
Gene Tree for MARCKSL1 (if available)

Paralogs for MARCKSL1 Gene

Pseudogenes.org Pseudogenes for MARCKSL1 Gene

genes like me logo Genes that share paralogs with MARCKSL1: view

No data available for Paralogs for MARCKSL1 Gene

Variants for MARCKSL1 Gene

Sequence variations from dbSNP and Humsavar for MARCKSL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3729976 -- 32,334,639(-) GGGCC(A/G)GAGAG synonymous-codon, reference, nc-transcript-variant
rs8176768 -- 32,337,626(-) ATGGA(C/G)GATAC upstream-variant-2KB
rs8176769 -- 32,337,340(-) CAGGA(C/T)TCTGG upstream-variant-2KB
rs8176770 -- 32,337,201(-) TTTGA(A/G)GGCTG upstream-variant-2KB
rs8176771 -- 32,336,302(-) GGCGC(A/G)CATTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MARCKSL1 Gene

Variant ID Type Subtype PubMed ID
dgv211n71 CNV Loss 21882294

Relevant External Links for MARCKSL1 Gene

HapMap Linkage Disequilibrium report
MARCKSL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCKSL1 Gene

Disorders for MARCKSL1 Gene

(3) Novoseek inferred disease relationships for MARCKSL1 Gene

Disease -log(P) Hits PubMed IDs
neural tube defects 34.9 3
nsclc 22.9 2
tumors 0 2
genes like me logo Genes that share disorders with MARCKSL1: view

No data available for UniProtKB/Swiss-Prot for MARCKSL1 Gene

Publications for MARCKSL1 Gene

  1. Promoter sequence, expression, and fine chromosomal mapping of the human gene (MLP) encoding the MARCKS-like protein: identification of neighboring and linked polymorphic loci for MLP and MACS and use in the evaluation of human neural tube defects. (PMID: 9598313) Stumpo D.J. … Blackshear P.J. (Genomics 1998) 2 3 23
  2. Protein kinase C-mediated phosphorylation and calmodulin binding of recombinant myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein. (PMID: 8132675) Verghese G.M. … Blackshear P.J. (J. Biol. Chem. 1994) 3 23
  3. Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading. (PMID: 10827182) Yue L. … Li J. (J. Biol. Chem. 2000) 3 23
  4. Suppression of the lipopolysaccharide-induced expression of MARCKS-related protein (MRP) affects transmigration in activated RAW264.7 cells. (PMID: 19246034) Chun K.R. … Lee W.H. (Cell. Immunol. 2009) 3 23
  5. A cell motility screen reveals role for MARCKS-related protein in adherens junction formation and tumorigenesis. (PMID: 19924305) Finlayson A.E. … Freeman K.W. (PLoS ONE 2009) 3 23

Products for MARCKSL1 Gene

Sources for MARCKSL1 Gene

Back to Top

Content