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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MARCKSL1 Gene

protein-coding   GIFtS: 52
GCID: GC01M032799

MARCKS-like 1

(Previous name: MARCKS-like protein )
(Previous symbol: MLP)
 Explore 10 diseases affiliated with
MARCKSL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MARCKSL1    

Aliases
for MARCKSL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
MARCKS-Like 11 2     MARCKS-Like Protein 12 3
MLP1 2 3 5     MARCKS-Like Protein1
MRP2 3 5     MACMARCKS2
F521 2     Mac-MARCKS3
MLP11 2     MARCKS-Related Protein2
MacMARCKS1 3     Mac-MARCKS3
Macrophage Myristoylated Alanine-Rich C Kinase Substrate2 3     

External Ids:    HGNC: 71421   Entrez Gene: 651082   Ensembl: ENSG000001751307   OMIM: 6029405   UniProtKB: P490063   

Export aliases for MARCKSL1 gene to outside databases

Previous GC identifers: GC01M032470 GC01M032573 GC01M030914


Summaries
for MARCKSL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MARCKSL1:
This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family
play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein
affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes
of this gene are located on the long arm of chromosomes 6 and 10. (provided by RefSeq, Jun 2012)

UniProtKB/Swiss-Prot: MRP_HUMAN, P49006
Function: Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium
formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles
formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal
migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin
signal transduction systems (By similarity)

Gene Wiki entry for MARCKSL1


Genomic Views
for MARCKSL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MARCKSL1 gene promoter:
         AP-1   ATF-2   AP-2gamma   PPAR-gamma1   AP-2beta   PPAR-gamma2   c-Jun   NF-kappaB1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MARCKSL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MARCKSL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARCKSL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.1   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p35.1

MARCKSL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCKSL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M032799:  view genomic region     (about GC identifiers)

Start:
 32,799,433 bp from pter      End:
 32,801,980 bp from pter
Size:
 2,548 bases      Orientation:
 minus strand

Proteins
for MARCKSL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MRP_HUMAN, P49006 (See protein sequence)
Recommended Name: MARCKS-related protein  
Size: 195 amino acids; 19529 Da
Subunit: Binds to filamentous actin (F-actin), but not to monomeric G-actin, independently of its phosphorylation
status (By similarity)
Subcellular location: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Associates with the membrane via
the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the
effector domain with membranes may be regulated by Ca(2+)/calmodulin (By similarity). In prostate cancers, detected in
the cytoplasm and associated with apical or basal membranes (By similarity)
Secondary accessions: D3DPQ0 Q5TEE6 Q6NXS5

Explore the universe of human proteins at neXtProt for MARCKSL1: NX_P49006

Post-translational modifications:

  • Phosphorylation at Ser-120 and Thr-178 are non-redundantly catalyzed by MAPK8 in vivo. Phosphorylation at Thr-148 is
    • preferentially catalyzed by MAPK8 in vivo, but this modification can also be catalyzed by other kinases in the absence
    of MAPK8 (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49006

    • MARCKSL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_075385.1  
    ENSEMBL proteins: 
     ENSP00000362638  

    Human Recombinant Protein Products: 
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    Novus Biologicals MARCKSL1 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MARCKSL1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IDA--


    MARCKSL1 for ontologies           About GeneDecksing



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    Uscn Antibodies for MARCKSL1
    ThermoFisher Antibodies for MARCKSL1

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    Uscn ELISAs and CLIAs for MARCKSL1

    Protein Domains /
    Families
    for MARCKSL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MARCKSL1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002101 MARCKS

    Graphical View of Domain Structure for InterPro Entry P49006

    ProtoNet protein and cluster: P49006

    1 Blocks protein family: IPB002101 Myristoylated alanine-rich C-kinase substrate MARCKS

    UniProtKB/Swiss-Prot: MRP_HUMAN, P49006
    Similarity: Belongs to the MARCKS family


    Function
    for MARCKSL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MRP_HUMAN, P49006
    Function: Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium
    formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles
    formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal
    migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin
    signal transduction systems (By similarity)

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARCKSL1
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate MARCKSL1 (see all 42):
    hsa-miR-323-3p hsa-miR-4328 hsa-miR-764 hsa-miR-449a hsa-miR-890 hsa-miR-149 hsa-miR-3613-3p hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmid: MARCKSL1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MARCKSL1 (see all 7)
    OriGene shRNA RFP: MARCKSL1
    OriGene siRNA: MARCKSL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARCKSL1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MARCKSL1

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for MARCKSL1

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MARCKSL1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005516calmodulin binding IEA--


    MARCKSL1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for MARCKSL1: Marcksl1tm1Fsh Marcksl1tm1Stl
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Marcksl1):
     embryogenesis  immune system  mortality/aging  nervous system  reproductive system 
     vision/eye 

    MARCKSL1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MARCKSL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Fc gamma R-mediated phagocytosis
    		Fc gamma R-mediated phagocytosis1.00
    2Leishmaniasis
    		Leishmaniasis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for MARCKSL1):
        Fc gamma R-mediated phagocytosis
    Leishmaniasis


    MARCKSL1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MARCKSL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/8 Interacting proteins for MARCKSL1 (P490063 ENSP000003626384) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCTN2Q135613, ENSP000004089104I2D: score=2 STRING: ENSP00000408910
    APPBP2Q926243I2D: score=1 
    DDIT3P356383I2D: score=1 
    TLR2O606033I2D: score=1 
    PRKCDENSP000003316024STRING: ENSP00000331602
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0016192vesicle-mediated transport ----


    MARCKSL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MARCKSL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MARCKSL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MARCKSL1
    9 Novoseek chemical compound relationships for MARCKSL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phorbol 40.8 1 10830615 (1)
    phospholipid 38 8 9461483 (4), 9767142 (1), 10933895 (1), 10545211 (1) (see all 5)
    calcitriol 26.5 1 1733233 (1)
    lipid 25.7 10 9461483 (1), 9767142 (1), 10736562 (1), 10545211 (1) (see all 7)
    retinoic acid 8.67 1 1478921 (1)
    serine 7.31 2 12137567 (1)
    aspartate 6.26 1 12137567 (1)
    calcium 0 3 9112755 (3)
    tyrosine 0 2 11483670 (1), 12082093 (1)

    Search CenterWatch for drugs/clinical trials and news about MARCKSL1 / MRP 

    Transcripts
    for MARCKSL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MARCKSL1 gene: 
    NM_023009.6  

    Unigene Cluster for MARCKSL1:

    MARCKS-like 1
    Hs.75061  [show with all ESTs]
    Unigene Representative Sequence: BG911975
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000329421(uc001bvd.3)

    miRNA
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    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate MARCKSL1 (see all 42):
    hsa-miR-323-3p hsa-miR-4328 hsa-miR-764 hsa-miR-449a hsa-miR-890 hsa-miR-149 hsa-miR-3613-3p hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmid: MARCKSL1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MARCKSL1 (see all 7)
    OriGene shRNA RFP: MARCKSL1
    OriGene siRNA: MARCKSL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARCKSL1
    Clone
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    GenScript: all cDNA clones in your preferred vector: MARCKSL1 (NM_023009)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARCKSL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARCKSL1

    Additional cDNA sequence: 

    AL713653.1 AY007131.1 BC007904.2 BC066915.1 NR_052852.1 X70326.1 

    23 DOTS entries:

    DT.91695988  DT.97803163  DT.92457973  DT.453713  DT.100667734  DT.100887530  DT.92457972  DT.100839602 
    DT.91861939  DT.100883562  DT.100883574  DT.100883577  DT.121448451  DT.121448460  DT.121616013  DT.95237310 
    DT.95258815  DT.100883564  DT.121448296  DT.121448337  DT.121448372  DT.121448449  DT.95237292 

    24/803 AceView cDNA sequences (see all 803):

    BU581437 BM740987 BM720091 CR602280 AW192887 BM763708 CR624801 CB119025 
    CR617460 AV708949 AA128648 CR607885 BE514569 BE745798 BG025720 BU145787 
    AA335974 BM761072 CR594797 AA587423 AI951307 BM807439 CR591730 BE045828 

    GeneLoc Exon Structure


    Expression
    for MARCKSL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MARCKSL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCAGCCAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MARCKSL1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MARCKSL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MARCKSL1

    SOURCE GeneReport for Unigene cluster: Hs.75061
        SABiosciences Custom PCR Arrays for MARCKSL1
    Primer
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MARCKSL1

    Orthologs
    for MARCKSL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MARCKSL1 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MARCKSL11 MARCKS-like 1 62.84(n)
    56.28(a)    		   770764  NM_001080718.1  NP_001074187.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MARCKSL16
    		 --
    		 44(a)
    		 1 ↔ 1
    		 GL343706.1(6454-16554)
    zebrafish
    (Danio rerio)    		 Actinopterygii BC058848.12   -- 80.38(n)    BC058848.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Akap2006
    		 A kinase anchor protein 200
    		 5(a)
    		 1 → many
    		 2L(8415690-8430984)


    ENSEMBL Gene Tree for MARCKSL1 (if available)
    TreeFam Gene Tree for MARCKSL1 (if available) 

    Paralogs
    for MARCKSL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MARCKSL1 gene
    MARCKS2  

    MARCKSL1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MARCKSL1
    PGOHUM00000238908 PGOHUM00000243394


    Genomic Variants
    for MARCKSL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/53 NCBI SNPs in MARCKSL1 are shown (see all 53)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs81767791,2
    		C--32799778(-) TTCCCCT/-GTTGT 4 -- nc-transcript-variantut311Minor allele frequency- -:0.01NS 168
    rs81767781,2
    		C,F,--32799878(-) TTCCCC/TAATTC 2 -- ut31 nc-transcript-varianttrp33Minor allele frequency- T:0.02NS NA WA 276
    rs1394883281,2
    		F--32800213(+) TGCTCA/TGCGCT 3 A nc-transcript-variantsyn11Minor allele frequency- T:0.00NA 4512
    rs37299761,2
    		C,F,--32800240(-) GGGCCG/AGAGAG 3 /P nc-transcript-variantsyn1 ese31Minor allele frequency- A:0.01NA 4542
    rs1828837271,2
    		--32800274(+) CCTGGA/GGCCCT 3 P L mis10--------
    rs1479208871,2
    		C,F--32800320(+) CTTGGC/TCTGGG 3 T A mis12Minor allele frequency- T:0.00NA EU 5773
    rs2018211491,2
    		--32800360(+) TTCCCG/TTCCTG 3 E D nc-transcript-variantmis10--------
    rs1511150741,2
    		C,F,--32800438(+) GCAGAA/GGAATC 3 S nc-transcript-variantsyn11Minor allele frequency- G:0.00NA 4548
    rs1409577281,2
    		C,F--32800451(+) CCCCAC/G/TCCTCC 5 D A G nc-transcript-variantmis12NA EU 5865
    rs1457617861,2
    		C,F--32800474(+) TTGAAG/AGACAG 3 /S nc-transcript-variantsyn12Minor allele frequency- A:0.00NA EU 5869

    HapMap Linkage Disequilibrium report for MARCKSL1 (32799433 - 32801980 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MARCKSL1: --

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    Disorders / Diseases
    for MARCKSL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MARCKSL1 for disorders           About GeneDecksing

    OMIM gene information: 602940    OMIM disorders: --

    10 diseases for MARCKSL1:    About MalaCards
    charcot-marie-tooth neuropathy    neural tube defect    anencephaly    neuropathy
    leishmaniasis    hepatitis b    lung cancer    breast cancer
    hepatitis    intermediate charcot-marie-tooth neuropathy

    3 Novoseek disease relationships for MARCKSL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neural tube defects 34.9 4 9598313 (2), 10736562 (1)
    nsclc 22.9 2 8879378 (2)
    tumors 0 3 17593529 (1), 19924305 (1)


    Export disorders for MARCKSL1 gene to outside databases

    Publications
    for MARCKSL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MARCKSL1 gene, integrated from 9 sources (see all 78):
    (articles sorted by number of sources associating them with MARCKSL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Promoter sequence, expression, and fine chromosomal mapping of the human gene (MLP) encoding the MARCKS-like protein: identification of neighboring and linked polymorphic loci for MLP and MACS and use in the evaluation of human neural tube defects. (PubMed id 9598313)1, 3, 9 Stumpo D.J....Blackshear P.J. (1998)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The regulation of MacMARCKS expression by integrin beta3. (PubMed id 17292354)1, 9 van den Bout I....Sonnenberg A. (2007)
    6. Investigation into the mechanism regulating MRP localization. (PubMed id 17897642)1, 9 van den Bout I....Sonnenberg A. (2008)
    7. Suppression of the lipopolysaccharide-induced expression of MARCKS-related protein (MRP) affects transmigration in activated RAW264.7 cells. (PubMed id 19246034)1, 9 Chun K.R....Lee W.H. (2009)
    8. Protein kinase C-mediated phosphorylation and calmodulin binding of recombinant myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein. (PubMed id 8132675)1, 9 Verghese G.M....Blackshear P.J. (1994)
    9. A cell motility screen reveals role for MARCKS-relate d protein in adherens junction formation and tumorigenesis. (PubMed id 19924305)1, 9 Finlayson A.E. and Freeman K.W. (2009)
    10. Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading. (PubMed id 10827182)1, 9 Yue L....Li J. (2000)

    External Searches for MARCKSL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing MARCKSL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 65108 HGNC: 7142 AceView: MLP Ensembl:ENSG00000175130 euGenes: HUgn65108
    ECgene: MARCKSL1 Kegg: 65108 H-InvDB: MARCKSL1

    Other Databases showing MARCKSL1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MARCKSL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MARCKSL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MARCKSL1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mlp/

    Intellectual Property
    for MARCKSL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MARCKSL1 gene:
    Search GeneIP for patents involving MARCKSL1

    GeneCards and IP:
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