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Aliases for MARCKSL1 Gene

Aliases for MARCKSL1 Gene

  • MARCKS Like 1 2 3 5
  • Macrophage Myristoylated Alanine-Rich C Kinase Substrate 3 4
  • MARCKS-Like Protein 1 3 4
  • Mac-MARCKS 3 4
  • MACMARCKS 3 4
  • MRP 3 4
  • MLP 3 4
  • MARCKS-Related Protein 3
  • MARCKS-Like Protein 2
  • MLP1 3
  • F52 3

External Ids for MARCKSL1 Gene

Previous HGNC Symbols for MARCKSL1 Gene

  • MLP

Previous GeneCards Identifiers for MARCKSL1 Gene

  • GC01M032470
  • GC01M032573
  • GC01M032799
  • GC01M030914

Summaries for MARCKSL1 Gene

Entrez Gene Summary for MARCKSL1 Gene

  • This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012]

GeneCards Summary for MARCKSL1 Gene

MARCKSL1 (MARCKS Like 1) is a Protein Coding gene. Diseases associated with MARCKSL1 include Intermediate Charcot-Marie-Tooth Neuropathy and Neural Tube Defects. Among its related pathways are Toxoplasmosis and Fc gamma R-mediated phagocytosis. GO annotations related to this gene include actin binding and calmodulin binding.

UniProtKB/Swiss-Prot for MARCKSL1 Gene

  • Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity).

Gene Wiki entry for MARCKSL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCKSL1 Gene

Genomics for MARCKSL1 Gene

Regulatory Elements for MARCKSL1 Gene

Enhancers for MARCKSL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G032390 1.4 Ensembl ENCODE 12 -56.6 -56621 5.2 CREB3L1 YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC NBN EIF3I LOC105378629 MARCKSL1 KPNA6 HDAC1 FAM229A TSSK3 BSDC1
GH01G032132 1.3 Ensembl ENCODE 10.5 +203.0 202969 2.3 HDGF PKNOX1 CREB3L1 ARNT SIN3A ZNF766 CBX5 FOS ZNF548 KLF13 SNRNP40 KPNA6 EIF3I ENSG00000229447 IQCC TSSK3 CCDC28B ENSG00000224066 DCDC2B TMEM234
GH01G032178 1.2 ENCODE 10.7 +156.0 156035 4.1 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC KPNA6 IQCC ENSG00000224066 DCDC2B TMEM234 EIF3I HDAC1 MARCKSL1 LCK FAM167B
GH01G032414 1 ENCODE 11 -77.7 -77736 0.2 HDGF PKNOX1 ATF1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 ZBTB8B ENSG00000254553 MARCKSL1 HDAC1 SYNC ENSG00000270850 GAPDHP20
GH01G031924 2.1 FANTOM5 Ensembl ENCODE dbSUPER 4.8 +400.5 400547 22.1 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 SNRNP40 ENSG00000229447 TSSK3 LOC105378626 EIF3I MTMR9LP KHDRBS1 HDAC1 ENSG00000224066 TMEM39B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MARCKSL1 on UCSC Golden Path with GeneCards custom track

Promoters for MARCKSL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004347 679 1801 HNRNPUL1 AGO1 ARID4B SIN3A SLC30A9 ZNF766 ZNF143 ZNF207 FOS KLF13

Genomic Location for MARCKSL1 Gene

Chromosome:
1
Start:
32,333,829 bp from pter
End:
32,336,379 bp from pter
Size:
2,551 bases
Orientation:
Minus strand

Genomic View for MARCKSL1 Gene

Genes around MARCKSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCKSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCKSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCKSL1 Gene

Proteins for MARCKSL1 Gene

  • Protein details for MARCKSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49006-MRP_HUMAN
    Recommended name:
    MARCKS-related protein
    Protein Accession:
    P49006
    Secondary Accessions:
    • D3DPQ0
    • Q5TEE6
    • Q6NXS5

    Protein attributes for MARCKSL1 Gene

    Size:
    195 amino acids
    Molecular mass:
    19529 Da
    Quaternary structure:
    • Binds to filamentous actin (F-actin), but not to monomeric G-actin, independently of its phosphorylation status.

neXtProt entry for MARCKSL1 Gene

Post-translational modifications for MARCKSL1 Gene

  • Phosphorylation at Ser-120 and Thr-178 are non-redundantly catalyzed by MAPK8 in vivo. Phosphorylation at Thr-148 is preferentially catalyzed by MAPK8 in vivo, but this modification can also be catalyzed by other kinases in the absence of MAPK8 (By similarity).
  • Ubiquitination at posLast=110110
  • Modification sites at PhosphoSitePlus

Other Protein References for MARCKSL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MARCKSL1 (MLP)
  • Santa Cruz Biotechnology (SCBT) Antibodies for MARCKSL1

No data available for DME Specific Peptides for MARCKSL1 Gene

Domains & Families for MARCKSL1 Gene

Protein Domains for MARCKSL1 Gene

Suggested Antigen Peptide Sequences for MARCKSL1 Gene

Graphical View of Domain Structure for InterPro Entry

P49006

UniProtKB/Swiss-Prot:

MRP_HUMAN :
  • Belongs to the MARCKS family.
Family:
  • Belongs to the MARCKS family.
genes like me logo Genes that share domains with MARCKSL1: view

No data available for Gene Families for MARCKSL1 Gene

Function for MARCKSL1 Gene

Molecular function for MARCKSL1 Gene

UniProtKB/Swiss-Prot Function:
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity).

Gene Ontology (GO) - Molecular Function for MARCKSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 24863880
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with MARCKSL1: view
genes like me logo Genes that share phenotypes with MARCKSL1: view

Animal Models for MARCKSL1 Gene

MGI Knock Outs for MARCKSL1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MARCKSL1 Gene

Localization for MARCKSL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCKSL1 Gene

Cytoplasm. Cell membrane. Membrane; Lipid-anchor. Note=Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the effector domain with membranes may be regulated by Ca(2+)/calmodulin (By similarity). In prostate cancers, detected in the cytoplasm and associated with apical or basal membranes (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARCKSL1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 4
cytoskeleton 3
cytosol 3
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MARCKSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with MARCKSL1: view

Pathways & Interactions for MARCKSL1 Gene

genes like me logo Genes that share pathways with MARCKSL1: view

Pathways by source for MARCKSL1 Gene

1 Cell Signaling Technology pathway for MARCKSL1 Gene
2 KEGG pathways for MARCKSL1 Gene

Gene Ontology (GO) - Biological Process for MARCKSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with MARCKSL1: view

No data available for SIGNOR curated interactions for MARCKSL1 Gene

Drugs & Compounds for MARCKSL1 Gene

(4) Drugs for MARCKSL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for MARCKSL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MARCKSL1: view

Transcripts for MARCKSL1 Gene

mRNA/cDNA for MARCKSL1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(803) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MARCKSL1 Gene

MARCKS-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCKSL1 Gene

No ASD Table

Relevant External Links for MARCKSL1 Gene

GeneLoc Exon Structure for
MARCKSL1
ECgene alternative splicing isoforms for
MARCKSL1

Expression for MARCKSL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MARCKSL1 Gene

mRNA differential expression in normal tissues according to GTEx for MARCKSL1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.5) and Brain - Substantia nigra (x4.1).

Protein differential expression in normal tissues from HIPED for MARCKSL1 Gene

This gene is overexpressed in Testis (14.9) and Brain (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MARCKSL1 Gene



Protein tissue co-expression partners for MARCKSL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MARCKSL1 Gene:

MARCKSL1

SOURCE GeneReport for Unigene cluster for MARCKSL1 Gene:

Hs.75061

Evidence on tissue expression from TISSUES for MARCKSL1 Gene

  • Nervous system(4.9)
  • Liver(4.2)
  • Muscle(4.2)
  • Intestine(3.5)
  • Skin(3.5)
  • Lung(3.1)
  • Eye(3)
  • Pancreas(2.2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with MARCKSL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARCKSL1 Gene

Orthologs for MARCKSL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCKSL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARCKSL1 35 34
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MARCKSL1 35 34
  • 95.02 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MARCKSL1 35 34
  • 93.81 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Marcksl1 35 16 34
  • 93.16 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Marcksl1 34
  • 92.53 (n)
oppossum
(Monodelphis domestica)
Mammalia MARCKSL1 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves MARCKSL1 35
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MARCKSL1 35
  • 35 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii marcksl1b 35
  • 43 (a)
OneToMany
marcksl1a 35
  • 34 (a)
OneToMany
Species where no ortholog for MARCKSL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARCKSL1 Gene

ENSEMBL:
Gene Tree for MARCKSL1 (if available)
TreeFam:
Gene Tree for MARCKSL1 (if available)

Paralogs for MARCKSL1 Gene

Pseudogenes.org Pseudogenes for MARCKSL1 Gene

genes like me logo Genes that share paralogs with MARCKSL1: view

No data available for Paralogs for MARCKSL1 Gene

Variants for MARCKSL1 Gene

Sequence variations from dbSNP and Humsavar for MARCKSL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000340570 -- 32,334,347(+) AGGAG(C/T)ATTTC nc-transcript-variant, utr-variant-3-prime
rs1000801599 -- 32,335,335(+) CCCCC(A/C)CCCCC intron-variant
rs1001028949 -- 32,336,374(+) CGGTC(C/G)GGTAC upstream-variant-2KB
rs1001346509 -- 32,335,746(+) CAGGG(C/G)CCGGC intron-variant
rs1001500748 -- 32,336,237(+) CCGCC(C/T)GCCGC nc-transcript-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MARCKSL1 Gene

Variant ID Type Subtype PubMed ID
nsv1077308 CNV deletion 25765185
nsv1112529 CNV deletion 24896259

Variation tolerance for MARCKSL1 Gene

Residual Variation Intolerance Score: 53.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MARCKSL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MARCKSL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCKSL1 Gene

Disorders for MARCKSL1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MARCKSL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
intermediate charcot-marie-tooth neuropathy
neural tube defects
  • spina bifida
anencephaly
  • absence of a large part of the brain and the skull
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MARCKSL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MARCKSL1
genes like me logo Genes that share disorders with MARCKSL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARCKSL1 Gene

Publications for MARCKSL1 Gene

  1. Promoter sequence, expression, and fine chromosomal mapping of the human gene (MLP) encoding the MARCKS-like protein: identification of neighboring and linked polymorphic loci for MLP and MACS and use in the evaluation of human neural tube defects. (PMID: 9598313) Stumpo D.J. … Blackshear P.J. (Genomics 1998) 2 3 22 64
  2. Suppression of the lipopolysaccharide-induced expression of MARCKS-related protein (MRP) affects transmigration in activated RAW264.7 cells. (PMID: 19246034) Chun K.R. … Lee W.H. (Cell. Immunol. 2009) 3 22 64
  3. A cell motility screen reveals role for MARCKS-related protein in adherens junction formation and tumorigenesis. (PMID: 19924305) Finlayson A.E. … Freeman K.W. (PLoS ONE 2009) 3 22 64
  4. Investigation into the mechanism regulating MRP localization. (PMID: 17897642) van den Bout I. … Sonnenberg A. (Exp. Cell Res. 2008) 3 22 64
  5. The regulation of MacMARCKS expression by integrin beta3. (PMID: 17292354) van den Bout I. … Sonnenberg A. (Exp. Cell Res. 2007) 3 22 64

Products for MARCKSL1 Gene

Sources for MARCKSL1 Gene

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