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MARCKSL1 Gene

protein-coding   GIFtS: 57
GCID: GC01M032799

MARCKS-Like 1

(Previous name: MARCKS-like protein)
(Previous symbol: MLP)
  See MARCKSL1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MARCKS-Like 11 2     MACMARCKS2
MLP1 2 3 5     MLP12
MRP2 3 5     mac-MARCKS2
Macrophage Myristoylated Alanine-Rich C Kinase Substrate2 3     MARCKS-Related Protein2
MARCKS-Like Protein 12 3     Mac-MARCKS3
MARCKS-Like Protein1     MacMARCKS3
F522     

External Ids:    HGNC: 71421   Entrez Gene: 651082   Ensembl: ENSG000001751307   OMIM: 6029405   UniProtKB: P490063   

Export aliases for MARCKSL1 gene to outside databases

Previous GC identifers: GC01M032470 GC01M032573 GC01M030914


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MARCKSL1 Gene:
This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this
family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded
protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants.
Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. (provided by RefSeq, Jun 2012)

GeneCards Summary for MARCKSL1 Gene:
MARCKSL1 (MARCKS-like 1) is a protein-coding gene. Diseases associated with MARCKSL1 include intermediate charcot-marie-tooth neuropathy, and anencephaly. GO annotations related to this gene include actin binding and calmodulin binding.

UniProtKB/Swiss-Prot: MRP_HUMAN, P49006
Function: Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium
formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles
formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including
neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and
calmodulin signal transduction systems (By similarity)

Gene Wiki entry for MARCKSL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the MARCKSL1 gene promoter:
         AP-1   ATF-2   AP-2gamma   PPAR-gamma1   AP-2beta   PPAR-gamma2   c-Jun   NF-kappaB1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMARCKSL1 promoter sequence
   Search Chromatin IP Primers for MARCKSL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARCKSL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.1   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p35.1

MARCKSL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCKSL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M032799:  view genomic region     (about GC identifiers)

Start:
32,799,433 bp from pter      End:
32,801,980 bp from pter
Size:
2,548 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MRP_HUMAN, P49006 (See protein sequence)
Recommended Name: MARCKS-related protein  
Size: 195 amino acids; 19529 Da
Subunit: Binds to filamentous actin (F-actin), but not to monomeric G-actin, independently of its phosphorylation
status (By similarity)
Secondary accessions: D3DPQ0 Q5TEE6 Q6NXS5

Explore the universe of human proteins at neXtProt for MARCKSL1: NX_P49006

Explore proteomics data for MARCKSL1 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-120 and Thr-178 are non-redundantly catalyzed by MAPK8 in vivo. Phosphorylation at Thr-148
    is preferentially catalyzed by MAPK8 in vivo, but this modification can also be catalyzed by other kinases in the
    absence of MAPK8 (By similarity)1
  • Ubiquitination2 at Lys99, Lys106, Lys110
  • Modification sites at PhosphoSitePlus

  • See MARCKSL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_075385.1  
    ENSEMBL proteins: 
     ENSP00000362638  

    MARCKSL1 Human Recombinant Protein Products:

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    ProSpec Recombinant Protein for MARCKSL1
    Cloud-Clone Corp. Proteins for MARCKSL1

     
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    antibodies-online proteins for MARCKSL1 (8 products) 

     
    antibodies-online peptides for MARCKSL1

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    antibodies-online antibodies for MARCKSL1 (24 products) 

    MARCKSL1 Assay Products:

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    antibodies-online kits for MARCKSL1 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002101 MARCKS

    Graphical View of Domain Structure for InterPro Entry P49006

    ProtoNet protein and cluster: P49006

    1 Blocks protein domain: IPB002101 Myristoylated alanine-rich C-kinase substrate MARCKS

    UniProtKB/Swiss-Prot: MRP_HUMAN, P49006
    Similarity: Belongs to the MARCKS family


    Find genes that share domains with MARCKSL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRP_HUMAN, P49006
    Function: Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium
    formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles
    formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including
    neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and
    calmodulin signal transduction systems (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005516calmodulin binding IEA--
         
    Find genes that share ontologies with MARCKSL1           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Marcksl1):
     embryogenesis  hematopoietic system  immune system  mortality/aging  nervous system 
     reproductive system  vision/eye 

    Find genes that share phenotypes with MARCKSL1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MARCKSL1: Marcksl1tm1Fsh Marcksl1tm1Stl

       genOway: Develop your customized and physiologically relevant rodent model for MARCKSL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MARCKSL1:
    hsa-mir-615-3p (MIRT040338), hsa-mir-331-3p (MIRT043528), hsa-mir-335-5p (MIRT017631), hsa-mir-24-3p (MIRT030534), hsa-mir-7-5p (MIRT025785), hsa-mir-128-3p (MIRT021963), hsa-mir-30c-2-3p (MIRT038693), hsa-mir-708-5p (MIRT037754)

    Block miRNA regulation of human, mouse, rat MARCKSL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MARCKSL1 (see all 42):
    hsa-miR-323-3p hsa-miR-4328 hsa-miR-764 hsa-miR-449a hsa-miR-890 hsa-miR-149 hsa-miR-3613-3p hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidMARCKSL1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MARCKSL1

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    Sino Biological Human cDNA Clone for MARCKSL1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCKSL1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCKSL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MRP_HUMAN, P49006: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Associates with the membrane
    via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain.
    Association of the effector domain with membranes may be regulated by Ca(2+)/calmodulin (By similarity). In
    prostate cancers, detected in the cytoplasm and associated with apical or basal membranes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    nucleus3
    cytoskeleton2
    cytosol1
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IDA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with MARCKSL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MARCKSL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Leishmaniasis
    Leishmaniasis0.35
    2Fc gamma R-mediated phagocytosis
    Fc gamma R-mediated phagocytosis


    Find genes that share SuperPaths with MARCKSL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for MARCKSL1):
        Fc gamma R-mediated phagocytosis
    Leishmaniasis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MARCKSL1
    Interactions:

        Search GeneGlobe Interaction Network for MARCKSL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for MARCKSL1 (P490063 ENSP000003626384) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCTN2Q135613, ENSP000004089104I2D: score=2 STRING: ENSP00000408910
    APPBP2Q926243I2D: score=1 
    DDIT3P356383I2D: score=1 
    TLR2O606033I2D: score=1 
    PRKCDENSP000003316024STRING: ENSP00000331602
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008284positive regulation of cell proliferation IEA--

    Find genes that share ontologies with MARCKSL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MARCKSL1 (MRP)

    9 Novoseek inferred chemical compound relationships for MARCKSL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phorbol 40.8 1 10830615 (1)
    phospholipid 38 8 9461483 (4), 9767142 (1), 10933895 (1), 10545211 (1) (see all 5)
    calcitriol 26.5 1 1733233 (1)
    lipid 25.7 10 9461483 (1), 9767142 (1), 10736562 (1), 10545211 (1) (see all 7)
    retinoic acid 8.67 1 1478921 (1)
    serine 7.31 2 12137567 (1)
    aspartate 6.26 1 12137567 (1)
    calcium 0 3 9112755 (3)
    tyrosine 0 2 11483670 (1), 12082093 (1)



    Find genes that share compounds with MARCKSL1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MARCKSL1 gene: 
    NM_023009.6  

    Unigene Cluster for MARCKSL1:

    MARCKS-like 1
    Hs.75061  [show with all ESTs]
    Unigene Representative Sequence: BG911975
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000329421(uc001bvd.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MARCKSL1 (see all 42):
    hsa-miR-323-3p hsa-miR-4328 hsa-miR-764 hsa-miR-449a hsa-miR-890 hsa-miR-149 hsa-miR-3613-3p hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidMARCKSL1 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARCKSL1
      QuantiTect SYBR Green Assays in human, mouse, rat MARCKSL1
      QuantiFast Probe-based Assays in human, mouse, rat MARCKSL1

    Additional mRNA sequence: 

    AL713653.1 AY007131.1 BC007904.2 BC066915.1 NR_052852.1 X70326.1 

    23 DOTS entries:

    DT.91695988  DT.97803163  DT.92457973  DT.453713  DT.100667734  DT.100887530  DT.92457972  DT.100839602 
    DT.91861939  DT.100883562  DT.100883574  DT.100883577  DT.121448451  DT.121448460  DT.121616013  DT.95237310 
    DT.95258815  DT.100883564  DT.121448296  DT.121448337  DT.121448372  DT.121448449  DT.95237292 

    Selected AceView cDNA sequences (see all 803):

    AI469619 BM773264 AA316217 BQ437862 BF725220 BM910172 AA310021 BU182240 
    CD367739 AA988695 BU581753 BU168528 BM142244 AI863018 BQ427810 AW162902 
    AA552672 AA341683 BQ961610 H57878 BM764578 AA370971 BF923995 CR593904 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MARCKSL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCAGCCAGA
    MARCKSL1 Expression
    About this image


    MARCKSL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Thymus (Hematopoietic System)
             Thymus
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
    MARCKSL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MARCKSL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75061
        Custom PCR Arrays for MARCKSL1
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat MARCKSL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCKSL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MARCKSL1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Marcksl11 , 5 MARCKS-like 11, 5 93.16(n)1
    95.9(a)1
      4 (63.26 cM)5
    173571  NM_010807.41  NP_034937.11 
     1295135815 
    chicken
    (Gallus gallus)
    Aves MARCKSL16
    Gallus gallus MARCKS-like 1 (MARCKSL1), mRNA.
    41(a)
    1 ↔ 1
    23(5072000-5074434)
    lizard
    (Anolis carolinensis)
    Reptilia MARCKSL16
    MARCKS-like 1
    35(a)
    1 ↔ 1
    GL343706.1(6454-16554)
    zebrafish
    (Danio rerio)
    Actinopterygii BC058848.12   -- 80.38(n)    BC058848.1 


    ENSEMBL Gene Tree for MARCKSL1 (if available)
    TreeFam Gene Tree for MARCKSL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MARCKSL1 gene

    Find genes that share paralogs with MARCKSL1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for MARCKSL1
    PGOHUM00000238908 PGOHUM00000243394


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MARCKSL1 (see all 71)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs81767791,2
    C--32799778(-) TTCCCCT/-GTTGT 4 -- ut31 nc-transcript-variant1Minor allele frequency- -:0.01NS 168
    rs786664991,2
    C--32799778(+) ACAAC-/AGGGGAA 2 -- ut31 nc-transcript-variant0--------
    rs81767781,2
    C,F--32799878(-) TTCCCC/TAATTC 2 -- ut31 nc-transcript-varianttrp33Minor allele frequency- T:0.02NS NA WA 276
    rs1394883281,2
    F--32800213(+) TGCTCA/TGCGCT 3 A syn11Minor allele frequency- T:0.00NA 4512
    rs37299761,2
    C,F--32800240(-) GGGCCG/AGAGAG 3 /P syn1 ese31Minor allele frequency- A:0.01NA 4542
    rs1828837271,2
    --32800274(+) CCTGGA/GGCCCT 3 P L mis10--------
    rs1479208871,2
    C,F--32800320(+) CTTGGC/TCTGGG 3 T A mis12Minor allele frequency- T:0.00NA EU 5773
    rs2018211491,2
    --32800360(+) TTCCCG/TTCCTG 3 E D mis10--------
    rs1511150741,2
    C,F--32800438(+) GCAGAA/GGAATC 3 S syn11Minor allele frequency- G:0.00NA 4548
    rs1409577281,2
    C,F--32800451(+) CCCCAC/G/TCCTCC 5 D A G mis12NA EU 5865

    HapMap Linkage Disequilibrium report for MARCKSL1 (32799433 - 32801980 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MARCKSL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv211n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MARCKSL1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602940    OMIM disorders: --

    3 diseases for MARCKSL1:    
    About MalaCards
    intermediate charcot-marie-tooth neuropathy    anencephaly    neural tube defects


    Find genes that share disorders with MARCKSL1           About GenesLikeMe

    3 Novoseek inferred disease relationships for MARCKSL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neural tube defects 34.9 4 9598313 (2), 10736562 (1)
    nsclc 22.9 2 8879378 (2)
    tumors 0 3 17593529 (1), 19924305 (1)


    Export disorders for MARCKSL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MARCKSL1 gene, integrated from 10 sources (see all 85):
    (articles sorted by number of sources associating them with MARCKSL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Promoter sequence, expression, and fine chromosomal mapping of the human gene (MLP) encoding the MARCKS-like protein: identification of neighboring and linked polymorphic loci for MLP and MACS and use in the evaluation of human neural tube defects. (PubMed id 9598313)1, 3, 9 Stumpo D.J....Blackshear P.J. (Genomics 1998)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The regulation of MacMARCKS expression by integrin beta3. (PubMed id 17292354)1, 9 van den Bout I....Sonnenberg A. (Exp. Cell Res. 2007)
    6. Investigation into the mechanism regulating MRP localization. (PubMed id 17897642)1, 9 van den Bout I....Sonnenberg A. (Exp. Cell Res. 2008)
    7. Suppression of the lipopolysaccharide-induced expression of MARCKS-related protein (MRP) affects transmigration in activated RAW264.7 cells. (PubMed id 19246034)1, 9 Chun K.R....Lee W.H. (Cell. Immunol. 2009)
    8. Protein kinase C-mediated phosphorylation and calmodulin binding of recombinant myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein. (PubMed id 8132675)1, 9 Verghese G.M....Blackshear P.J. (J. Biol. Chem. 1994)
    9. A cell motility screen reveals role for MARCKS-related protein in adherens junction formation and tumorigenesis. (PubMed id 19924305)1, 9 Finlayson A.E. and Freeman K.W. (PLoS ONE 2009)
    10. Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading. (PubMed id 10827182)1, 9 Yue L....Li J. (J. Biol. Chem. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 65108 HGNC: 7142 AceView: MLP Ensembl:ENSG00000175130 euGenes: HUgn65108
    ECgene: MARCKSL1 Kegg: 65108 H-InvDB: MARCKSL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MARCKSL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MARCKSL1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mlp/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MARCKSL1 gene:
    Search GeneIP for patents involving MARCKSL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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