Aliases for MARCKSL1 Gene
External Ids for MARCKSL1 Gene
Previous HGNC Symbols for MARCKSL1 Gene
Previous GeneCards Identifiers for MARCKSL1 Gene
This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012]
GeneCards Summary for MARCKSL1 Gene
MARCKSL1 (MARCKS-Like 1) is a Protein Coding gene. Diseases associated with MARCKSL1 include intermediate charcot-marie-tooth neuropathy and anencephaly. Among its related pathways are Fc gamma R-mediated phagocytosis and Leishmaniasis. GO annotations related to this gene include actin binding and calmodulin binding.
UniProtKB/Swiss-Prot for MARCKSL1 Gene
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity).