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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MARCKS Gene

protein-coding   GIFtS: 62
GCID: GC06P114189

Myristoylated Alanine-Rich Protein Kinase C Substrate

(Previous names: myristoylated alanine-rich protein kinase C substrate (MARCKS,...)
(Previous symbol: MACS)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
Myristoylated Alanine-Rich Protein Kinase C Substrate1 2     80K-L2
MACS1 2 3 5     Myristoylated Alanine-Rich C-Kinase Substrate2
PKCSL2 3 5     phosphomyristin2
Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS, 80K-L)1 2     80K-L Protein3
Protein Kinase C Substrate, 80 KDa Protein, Light Chain2 3     MRACKS5
PRKCSL2 3     

External Ids:    HGNC: 67591   Entrez Gene: 40822   Ensembl: ENSG000001551307   OMIM: 1770615   UniProtKB: P299663   
ORGUL members:    fRNAdb10:FR206362      
H-InvDB12:HIT000091557    
NCBI13:BC028284    
NONCODE14:n335522 n342920 n333482      
RNAdb15:HIV1921    

Export aliases for MARCKS gene to outside databases

Previous GC identifers: GC06P114013 GC06P114201 GC06P114224 GC06P114285 GC06P111756 GC06P114179


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MARCKS Gene:
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and
is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin
inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The
protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. (provided
by RefSeq, Jul 2008)

GeneCards Summary for MARCKS Gene: 
MARCKS (myristoylated alanine-rich protein kinase C substrate) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with MARCKS include malignant syringoma, and small intestine adenocarcinoma, and among its related super-pathways are Regulation of Insulin Secretion and Regulation of Insulin Secretion by Free Fatty Acids. GO annotations related to this gene include protein kinase C binding and calmodulin binding.

UniProtKB/Swiss-Prot: MARCS_HUMAN, P29966
Function: MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin,
actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein

Gene Wiki entry for MARCKS Gene

fRNAdb sequence ontology for MARCKS:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for MARCKS

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MARCKS gene promoter:
         GATA-3   AP-1   ATF-2   MyoD   GATA-1   YY1   GATA-2   FOXO4   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMARCKS promoter sequence
   Search SABiosciences Chromatin IP Primers for MARCKS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARCKS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.2   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

MARCKS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCKS gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P114189:  view genomic region     (about GC identifiers)

Start:
114,178,527 bp from pter      End:
114,184,652 bp from pter
Size:
6,126 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MARCKS

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MARCS_HUMAN, P29966 (See protein sequence)
Recommended Name: Myristoylated alanine-rich C-kinase substrate  
Size: 332 amino acids; 31555 Da
Subcellular location: Cytoplasm, cytoskeleton (Probable). Membrane; Lipid-anchor (By similarity)
Secondary accessions: E1P560 Q2LA83 Q5TDB7

Explore the universe of human proteins at neXtProt for MARCKS: NX_P29966

Explore proteomics data for MARCKS at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P29966

  • MARCKS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MARCKS Protein Expression
    REFSEQ proteins: NP_002347.5  
    ENSEMBL proteins: 
     ENSP00000357624  
    Reactome Protein details: P29966
    Human Recombinant Protein Products for MARCKS: 
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    OriGene Custom Protein Services for MARCKS
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    Novus Biologicals MARCKS Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MARCKS 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005813centrosome IEA--
    GO:0005886plasma membrane TAS--
    GO:0005938cell cortex IEA--
    GO:0015629actin cytoskeleton TAS1560845

    MARCKS for ontologies           About GeneDecksing



    MARCKS Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MARCKS
    R&D Systems Antibodies for MARCKS
    Cell Signaling Technology (CST) Antibodies for MARCKS 
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    GenScript Superior Antibodies for MARCKS
    Novus Biologicals MARCKS Antibodies
    Abcam antibodies for MARCKS
    Cloud-Clone Corp. Antibodies for MARCKS 
    ThermoFisher Antibodies for MARCKS
    LSBio Antibodies in human, mouse, rat for MARCKS 

    Assay Products for MARCKS: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
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    Cell Signaling Technology (CST) Sandwich ELISA Kits for MARCKS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MARCKS 
    Cloud-Clone Corp. CLIAs for MARCKS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR002101 MARCKS

    Graphical View of Domain Structure for InterPro Entry P29966

    ProtoNet protein and cluster: P29966

    1 Blocks protein domain: IPB002101 Myristoylated alanine-rich C-kinase substrate MARCKS

    UniProtKB/Swiss-Prot: MARCS_HUMAN, P29966
    Similarity: Belongs to the MARCKS family


    MARCKS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARCS_HUMAN, P29966
    Function: MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin,
    actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding IEA--
    GO:0005515protein binding ----
    GO:0005516calmodulin binding IEA--
    GO:0051015actin filament binding TAS1560845
         
    MARCKS for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MARCKS:
     Decreased cilium length after  

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Marcks):
     behavior/neurological  craniofacial  embryogenesis  growth/size  mortality/aging 
     nervous system  skeleton  vision/eye 

    MARCKS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Marckstm1Pjb for MARCKS

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MARCKS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MARCKS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARCKS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARCKS 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MARCKS:
    hsa-mir-21 (MIRT001221)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARCKS
    8/115 QIAGEN miScript miRNA Assays for microRNAs that regulate MARCKS (see all 115):
    hsa-miR-579 hsa-miR-300 hsa-miR-188-5p hsa-miR-128 hsa-miR-4315 hsa-miR-30d hsa-miR-30a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidMARCKS 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MARCKS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARCKS

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MARCKS
    Sirion Biotech Customized adenovirus for overexpression of MARCKS

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MARCKS (see all 5)
    OriGene ORF clones in mouse, rat for MARCKS
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    GenScript: all cDNA clones in your preferred vector: MARCKS (NM_002356)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCKS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCKS
    Sirion Biotech Customized lentivirus for stable overexpression of MARCKS 
                         Customized lentivirus expression plasmids for stable overexpression of MARCKS 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCKS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MARCKS About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Regulation of Insulin Secretion
    Regulation of Insulin Secretion0.74
    Integration of energy metabolism0.74
    2Regulation of Insulin Secretion by Free Fatty Acids
    Regulation of Insulin Secretion by Acetylcholine0.64
    3Metabolism
    Metabolism0.40
    4MicroRNAs in cancer
    MicroRNAs in cancer
    5Fc gamma R-mediated phagocytosis
    Fc gamma R-mediated phagocytosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MARCKS
        Ca, cAMP and Lipid Signaling

    1 BioSystems Pathway for MARCKS
        BDNF signaling pathway

    4        Reactome Pathways for MARCKS
        Regulation of Insulin Secretion by Acetylcholine
    Metabolism
    Regulation of Insulin Secretion
    Integration of energy metabolism


    2         Kegg Pathways  (Kegg details for MARCKS):
        Fc gamma R-mediated phagocytosis
    MicroRNAs in cancer


    MARCKS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MARCKS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/23 Interacting proteins for MARCKS (P299663 ENSP000003576244) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=3 STRING: ENSP00000349467
    CALM2P621583, ENSP000002722984I2D: score=3 STRING: ENSP00000272298
    CALM3P621583I2D: score=3 
    NMT1P304193, ENSP000002589604I2D: score=3 STRING: ENSP00000258960
    TOB1P506163, ENSP000002689574I2D: score=3 STRING: ENSP00000268957
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0050796regulation of insulin secretion TAS--

    MARCKS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MARCKS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MARCKS (MARCS)

    10/46 Novoseek inferred chemical compound relationships for MARCKS gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pkcs 64.1 6 7989336 (1), 8601451 (1), 8519597 (1), 18296509 (1)
    pip2 63.5 15 19475567 (4), 9259558 (2), 15052337 (2), 16689643 (1) (see all 6)
    1,2-diacylglycerol 62.8 1 15788407 (1)
    fasudil 53.5 2 19475567 (1)
    phorbol 51.6 7 8627336 (2), 9150270 (2), 9990296 (1), 8437859 (1) (see all 5)
    bisindolylmaleimide 51.3 5 9990296 (1), 9150270 (1)
    phosphatidylserine 47.9 11 8611023 (3), 7840634 (1), 8486722 (1)
    myristic acid 45 1 8702537 (1)
    gf 109203x 41.8 3 7931322 (1), 18768137 (1)
    phosphatidylcholine 39.8 26 9601059 (5), 8627336 (4), 8906563 (2), 8486722 (2) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about MARCKS / MARCS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for MARCKS gene: 
    NM_002356.5  

    Unigene Clusters for MARCKS:

    Myristoylated alanine-rich protein kinase C substrate
    Hs.519909  [show with all ESTs], Hs.712658  [show with all ESTs]
    Unigene Representative Sequences: NM_002356, AK074526
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368635(uc003pvy.4)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARCKS
    8/115 QIAGEN miScript miRNA Assays for microRNAs that regulate MARCKS (see all 115):
    hsa-miR-579 hsa-miR-300 hsa-miR-188-5p hsa-miR-128 hsa-miR-4315 hsa-miR-30d hsa-miR-30a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidMARCKS 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARCKS
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARCKS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARCKS

    Additional mRNA sequence: AK074526.1 

    19 DOTS entries:

    DT.95363577  DT.87018078  DT.97859974  DT.100823567  DT.100823579  DT.95097816  DT.121347813  DT.99957146 
    DT.95313883  DT.92444751  DT.95363569  DT.95363592  DT.100038821  DT.100823570  DT.86843252  DT.95073736 
    DT.99948747  DT.100823582  DT.95363579 

    24/585 AceView cDNA sequences (see all 585):

    AI278899 AA953519 BU628623 BC039492 AA332063 AI076187 BU686839 W79596 
    BM662842 T49095 BU678392 AA328983 H27827 AA328327 H90644 AI393830 
    BM686138 AI039810 BU675994 AA334956 AI817869 AI829778 CD674220 BM984923 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MARCKS expression in normal human tissues (normalized intensities)      MARCKS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTGTAAAT
    MARCKS Expression
    About this image


    MARCKS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Adipose (Muscoskeletal System)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical cord blood-derived hematopoietic stem cells

    See MARCKS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MARCKS

    SOURCE GeneReport for Unigene clusters: Hs.519909 Hs.712658
        SABiosciences Custom PCR Arrays for MARCKS
    Primer
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    OriGene qPCR primer pairs and template standards for MARCKS
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARCKS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCKS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MARCKS gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Marcks1 , 5 myristoylated alanine rich protein kinase C substrate1, 5 79.74(n)1
    76.14(a)1
      10 (19.49 cM)5
    171181  NM_008538.21  NP_032564.11 
     371333755 
    chicken
    (Gallus gallus)
    Aves MARCKS1 myristoylated alanine-rich protein kinase C substrate 77.05(n)
    75.46(a)
      396473  NM_205480.1  NP_990811.1 
    lizard
    (Anolis carolinensis)
    Reptilia MARCKS6
    Uncharacterized protein
    63(a)
    1 ↔ 1
    1(187719515-187724037)
    African clawed frog
    (Xenopus laevis)
    Amphibia marcks-prov2 myristoylated alanine rich protein kinase C substrate 85.5(n)    AF017299.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AL716290.12   -- 74.5(n)    AL716290.1 


    ENSEMBL Gene Tree for MARCKS (if available)
    TreeFam Gene Tree for MARCKS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/165 SNPs in MARCKS are shown (see all 165)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs737685671,2
    C,F--114176771(+) TTTCAG/AGTTGG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1403432571,2
    C--114176983(+) ACAATA/GTTCAG 1 -- us2k10--------
    rs1454095341,2
    C--114177098(+) AAACTA/GTTTGA 1 -- us2k10--------
    rs1381421281,2
    C--114177244(+) TTTGGA/GAAGAA 1 -- us2k10--------
    rs1426398611,2
    --114177329(+) AAAAGC/TGTCTG 1 -- us2k10--------
    rs455682311,2
    C,F--114177371(+) TGGAGG/ATATCC 1 -- us2k15Minor allele frequency- A:0.00NS 188
    rs454771931,2
    C,F--114177395(+) AGAAGC/GTTTTC 1 -- us2k110Minor allele frequency- G:0.09NS WA CSA NA EA 550
    rs1915759681,2
    --114177424(+) TTGGAC/GAGCTC 1 -- us2k10--------
    rs1414913321,2
    --114177427(+) GAGAGC/TTCAGG 1 -- us2k10--------
    rs1158681711,2
    F--114177647(+) GATTCG/TTCTAC 1 -- us2k11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for MARCKS (114178527 - 114184652 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MARCKS:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv482098CNV Loss20164927

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 177061OMIM information: 122550 143400 604519 608545    
    20/24 diseases for MARCKS (see all 24):    About MalaCards
    malignant syringoma    small intestine adenocarcinoma    syringoma    anoxia
    brain disease    liver cirrhosis    choroiditis    neuroblastoma
    alzheimer's disease    asthma    retinoblastoma    chronic lymphocytic leukemia
    cholangiocarcinoma    melanoma    cerebritis    colorectal cancer
    adenocarcinoma    endotheliitis    leukemia    hepatocellular carcinoma


    MARCKS for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/17 Novoseek inferred disease relationships for MARCKS gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bipolar disorder 32.2 1 11790517 (1)
    lymphocytic leukemia chronic b-cell 19.5 1 7769846 (1)
    microsatellite instability 18.7 2 19852062 (1), 12140758 (1)
    mania 17.6 1 18789340 (1)
    glioma 15.1 8 8455032 (2), 9150270 (2), 7964753 (2), 8906563 (1) (see all 5)
    brain diseases 4.24 1 10757536 (1)
    asthma 0 1 14716307 (1)
    senile plaques 0 1 10757536 (1)
    necrosis 0 3 9808756 (1), 1860846 (1), 8433016 (1)
    metastasis 0 3 20047593 (2)

    Human Genome Epidemiology (HuGE) Navigator: MARCKS (1 document)

    Export disorders for MARCKS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MARCKS gene, integrated from 9 sources (see all 269):
    (articles sorted by number of sources associating them with MARCKS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human myristoylated alanine-rich C kinase substrate (MARCKS) gene (MACS). Analysis of its gene product, promoter, and chromosomal localization. (PubMed id 1860846)1, 2, 9 Harlan D.M.... Blackshear P.J. (1991)
    2. Relationship between the major protein kinase C substrates acidic 80- kDa protein-kinase-C substrate (80K) and myristoylated alanine-rich C- kinase substrate (MARCKS). Members of a gene family or equivalent genes in different species. (PubMed id 1396720)1, 2, 9 Herget T.... Rozengurt E. (1992)
    3. PRK1 phosphorylates MARCKS at the PKC sites: serine 152, serine 156 and serine 163. (PubMed id 8557118)1, 2, 9 Palmer R.H....Parker P.J. (1996)
    4. Molecular cloning and chromosomal mapping of a cDNA encoding human 80K-L protein: major substrate for protein kinase C. (PubMed id 1427823)1, 2, 9 Sakai K.... Shimizu N. (1992)
    5. MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin. (PubMed id 1560845)1, 3, 9 Hartwig J.H....Aderem A. (1992)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    9. The MARCKS family of cellular protein kinase C substr ates. (PubMed id 8420923)1, 3 Blackshear P.J. (1993)
    10. MARCKS regulates lamellipodia formation induced by IG F-I via association with PIP2 and beta-actin at membrane microdomains. (PubMed id 19475567)1, 9 Yamaguchi H....Sasaki Y. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4082 HGNC: 6759 AceView: MARCKS Ensembl:ENSG00000155130 euGenes: HUgn4082
    ECgene: MARCKS Kegg: 4082 H-InvDB: MARCKS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MARCKS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MARCKS Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/marcks/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MARCKS gene:
    Search GeneIP for patents involving MARCKS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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