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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MARCKS Gene

protein-coding   GIFtS: 61
GCID: GC06P114179

myristoylated alanine-rich protein kinase C substrate

(Previous names: myristoylated alanine-rich protein kinase C substrate (MARCKS,...)
(Previous symbol: MACS)
 Explore 26 diseases affiliated with
MARCKS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MARCKS    

Aliases
for MARCKS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Myristoylated Alanine-Rich Protein Kinase C Substrate1 2     PRKCSL2 3
MACS1 2 3 5     Myristoylated Alanine-Rich C-Kinase Substrate2
PKCSL1 2 3 5     Phosphomyristin1
80K-L1 2     80K-L Protein3
Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS, 80K-L)1 2     MRACKS5
Protein Kinase C Substrate, 80 KDa Protein, Light Chain2 3     

External Ids:    HGNC: 67591   Entrez Gene: 40822   Ensembl: ENSG000001551307   OMIM: 1770615   UniProtKB: P299663   
ORGUL members:         
NONCODE:n342920    

Export aliases for MARCKS gene to outside databases

Previous GC identifers: GC06P114013 GC06P114201 GC06P114224 GC06P114285 GC06P111756


Summaries
for MARCKS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MARCKS:
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an
actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its
association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought
to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MARCS_HUMAN, P29966
Function: MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin,
and synapsin. MARCKS is a filamentous (F) actin cross-linking protein

Gene Wiki entry for MARCKS


Genomic Views
for MARCKS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MARCKS gene promoter:
         GATA-3   AP-1   ATF-2   MyoD   GATA-1   YY1   GATA-2   FOXO4   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MARCKS promoter sequence
   Search SABiosciences Chromatin IP Primers for MARCKS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARCKS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.2   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

MARCKS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCKS gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P114179:  view genomic region     (about GC identifiers)

Start:
 114,178,527 bp from pter      End:
 114,184,652 bp from pter
Size:
 6,126 bases      Orientation:
 plus strand

Proteins
for MARCKS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MARCS_HUMAN, P29966 (See protein sequence)
Recommended Name: Myristoylated alanine-rich C-kinase substrate  
Size: 332 amino acids; 31555 Da
Subcellular location: Cytoplasm, cytoskeleton (Probable). Membrane; Lipid-anchor (By similarity)
Secondary accessions: E1P560 Q2LA83 Q5TDB7

Explore the universe of human proteins at neXtProt for MARCKS: NX_P29966

Post-translational modifications:

  • Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P29966

    • MARCKS Protein expression data from MOPED and PaxDb:    About this image 
    MARCKS Protein Expression
    REFSEQ proteins: NP_002347.5  
    ENSEMBL proteins: 
     ENSP00000357624  
    Reactome Protein details: P29966
    Human Recombinant Protein Products for MARCKS: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for MARCKS 
    GenScript Custom Purified and Recombinant Proteins Services for MARCKS
    Novus Biologicals MARCKS Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MARCKS

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005813centrosome IEA--
    GO:0005886plasma membrane TAS--
    GO:0005938cell cortex IEA--
    GO:0015629actin cytoskeleton TAS1560845

    MARCKS for ontologies           About GeneDecksing



    MARCKS Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MARCKS
    R&D Systems Antibodies for MARCKS
    Cell Signaling Technology (CST) Antibodies for MARCKS 
    OriGene Antibodies (see all 2): MARCKS
    OriGene Custom Antibody Services for MARCKS 
    GenScript Superior Antibodies for MARCKS
    Novus Biologicals MARCKS Antibodies
    Abcam antibodies for MARCKS 
    Uscn Antibodies for MARCKS
    ThermoFisher Antibodies for MARCKS

    Assay Products for MARCKS: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MARCKS
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MARCKS
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MARCKS

    Protein Domains /
    Families
    for MARCKS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MARCKS for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002101 MARCKS

    Graphical View of Domain Structure for InterPro Entry P29966

    ProtoNet protein and cluster: P29966

    1 Blocks protein family: IPB002101 Myristoylated alanine-rich C-kinase substrate MARCKS

    UniProtKB/Swiss-Prot: MARCS_HUMAN, P29966
    Similarity: Belongs to the MARCKS family


    Function
    for MARCKS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARCS_HUMAN, P29966
    Function: MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin,
    and synapsin. MARCKS is a filamentous (F) actin cross-linking protein

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding IEA--
    GO:0005515protein binding ----
    GO:0005516calmodulin binding IEA--
    GO:0051015actin filament binding TAS1560845
         
    MARCKS for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MARCKS:
     Decreased cilium length after  

         8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Marcks):
     behavior/neurological  craniofacial  embryogenesis  growth/size  mortality/aging 
     nervous system  skeleton  vision/eye 

    MARCKS for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Marckstm1Pjb for MARCKS
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MARCKS 

    miRNA
    Products:            		miRTarBase miRNAs that target MARCKS:
    hsa-mir-21 (MIRT001221)

    OriGene 3'-UTR Clone: MARCKS
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARCKS
    8/115 QIAGEN miScript miRNA Assays for microRNAs that regulate MARCKS (see all 115):
    hsa-miR-579 hsa-miR-300 hsa-miR-188-5p hsa-miR-128 hsa-miR-4315 hsa-miR-30d hsa-miR-30a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: MARCKS 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MARCKS (see all 4)
    OriGene shRNA RFP: MARCKS
    OriGene siRNA: MARCKS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARCKS
    Sirion Biotech Custom design and validation of potent shRNA sequences against MARCKS 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MARCKS
    Sirion Biotech Customized adenovirus for overexpression of MARCKS 
    Sirion Biotech Customized adenovirus for potent knockdown of MARCKS

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MARCKS (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MARCKS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MARCKS (NM_002356)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCKS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCKS 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MARCKS
    Search LifeMap BioReagents cell lines for MARCKS
    Sirion Biotech Customized stable knockdown cell line services for MARCKS 
    Sirion Biotech Customized inducible knockdown cell line services for MARCKS
    Sirion Biotech Customized stable overexpressing cell line services for MARCKS
    Sirion Biotech Customized inducible overexpressing cell line services for MARCKS

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCKS


    Pathways & Interactions
    for MARCKS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of Insulin Secretion
    		Regulation of Insulin Secretion1.00
    		Integration of energy metabolism0.74
    2Ca, cAMP and Lipid Signaling
    		Ca, cAMP and Lipid Signaling1.00
    3Fc gamma R-mediated phagocytosis
    		Fc gamma R-mediated phagocytosis1.00
    4Metabolism
    		Metabolism1.00
    5Regulation of Insulin Secretion by Free Fatty Acids
    		Regulation of Insulin Secretion by Acetylcholine0.64

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MARCKS
        Ca, cAMP and Lipid Signaling

    4        Reactome Pathways for MARCKS
        Regulation of Insulin Secretion by Acetylcholine
    Metabolism
    Regulation of Insulin Secretion
    Integration of energy metabolism


    1         Kegg Pathway  (Kegg details for MARCKS):
        Fc gamma R-mediated phagocytosis


    MARCKS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MARCKS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/23 Interacting proteins for MARCKS (P299663 ENSP000003576244) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=3 STRING: ENSP00000349467
    CALM2P621583, ENSP000002722984I2D: score=3 STRING: ENSP00000272298
    CALM3P621583I2D: score=3 
    NMT1P304193, ENSP000002589604I2D: score=3 STRING: ENSP00000258960
    TOB1P506163, ENSP000002689574I2D: score=3 STRING: ENSP00000268957
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0050796regulation of insulin secretion TAS--

    MARCKS for ontologies           About GeneDecksing



    Drugs & Compounds
    for MARCKS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MARCKS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MARCKS
    10/46 Novoseek chemical compound relationships for MARCKS gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pkcs 64.1 6 7989336 (1), 8601451 (1), 8519597 (1), 18296509 (1)
    pip2 63.5 15 19475567 (4), 9259558 (2), 15052337 (2), 16689643 (1) (see all 6)
    1,2-diacylglycerol 62.8 1 15788407 (1)
    fasudil 53.5 2 19475567 (1)
    phorbol 51.6 7 8627336 (2), 9150270 (2), 9990296 (1), 8437859 (1) (see all 5)
    bisindolylmaleimide 51.3 5 9990296 (1), 9150270 (1)
    phosphatidylserine 47.9 11 8611023 (3), 7840634 (1), 8486722 (1)
    myristic acid 45 1 8702537 (1)
    gf 109203x 41.8 3 7931322 (1), 18768137 (1)
    phosphatidylcholine 39.8 26 9601059 (5), 8627336 (4), 8906563 (2), 8486722 (2) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about MARCKS / MARCS 

    Transcripts
    for MARCKS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MARCKS gene: 
    NM_002356.5  

    Unigene Clusters for MARCKS:

    Myristoylated alanine-rich protein kinase C substrate
    Hs.519909  [show with all ESTs], Hs.712658  [show with all ESTs]
    Unigene Representative Sequences: NM_002356, AK074526
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368635(uc003pvy.4)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MARCKS
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARCKS
    8/115 QIAGEN miScript miRNA Assays for microRNAs that regulate MARCKS (see all 115):
    hsa-miR-579 hsa-miR-300 hsa-miR-188-5p hsa-miR-128 hsa-miR-4315 hsa-miR-30d hsa-miR-30a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: MARCKS 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MARCKS (see all 4)
    OriGene shRNA RFP: MARCKS
    OriGene siRNA: MARCKS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARCKS
    Sirion Biotech Custom design and validation of potent shRNA sequences against MARCKS 
    Clone
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    GenScript: all cDNA clones in your preferred vector: MARCKS (NM_002356)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCKS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCKS 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MARCKS
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MARCKS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARCKS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARCKS

    Additional cDNA sequence: AK074526.1 

    19 DOTS entries:

    DT.95363577  DT.87018078  DT.97859974  DT.100823567  DT.100823579  DT.95097816  DT.121347813  DT.95313883 
    DT.92444751  DT.95363569  DT.99957146  DT.95363592  DT.100038821  DT.100823570  DT.86843252  DT.95073736 
    DT.99948747  DT.100823582  DT.95363579 

    24/585 AceView cDNA sequences (see all 585):

    H26445 BU686839 AA031902 AA348702 AI278899 BF447244 CB109810 AA953519 
    AA332063 AI076187 W79596 BM667300 BM984923 D31121 AI393830 AI969902 
    BM738991 H27827 BF438622 BU678392 AI741549 AA896967 H90644 AA334956 

    GeneLoc Exon Structure


    Expression
    for MARCKS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MARCKS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTGTAAAT
    MARCKS Expression
    About this image

    MARCKS expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MARCKS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MARCKS

    SOURCE GeneReport for Unigene clusters: Hs.519909 Hs.712658
        SABiosciences Custom PCR Arrays for MARCKS
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MARCKS
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MARCKS
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARCKS
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCKS

    Orthologs
    for MARCKS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MARCKS gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Marcks1 , 5 myristoylated alanine rich protein kinase C substrate1, 5 79.74(n)1
    76.14(a)1    		   10 (19.49 cM)5
    171181  NM_008538.21  NP_032564.11 
     371333755 
    chicken
    (Gallus gallus)    		 Aves MARCKS1 myristoylated alanine-rich protein kinase C substrate 77.05(n)
    75.46(a)    		   396473  NM_205480.1  NP_990811.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MARCKS6
    		 --
    		 62(a)
    		 1 ↔ 1
    		 1(187719515-187724023)
    African clawed frog
    (Xenopus laevis)    		 Amphibia marcks-prov2 myristoylated alanine rich protein kinase C substrate 85.5(n)    AF017299.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii AL716290.12   -- 74.5(n)    AL716290.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Akap2006
    		 A kinase anchor protein 200
    		 8(a)
    		 1 → many
    		 2L(8415690-8430984)


    ENSEMBL Gene Tree for MARCKS (if available)
    TreeFam Gene Tree for MARCKS (if available) 

    Paralogs
    for MARCKS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MARCKS gene
    MARCKSL12  

    MARCKS for paralogs           About GeneDecksing



    Genomic Variants
    for MARCKS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/144 NCBI SNPs in MARCKS are shown (see all 144)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs737685671,2
    		C--114176771(+) TTTCAG/AGTTGG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1403432571,2
    		--114176983(+) ACAATA/GTTCAG 1 -- us2k10--------
    rs1454095341,2
    		--114177098(+) AAACTA/GTTTGA 1 -- us2k10--------
    rs1381421281,2
    		--114177244(+) TTTGGA/GAAGAA 1 -- us2k10--------
    rs1426398611,2
    		--114177329(+) AAAAGC/TGTCTG 1 -- us2k10--------
    rs455682311,2
    		C--114177371(+) TGGAGG/ATATCC 1 -- us2k15Minor allele frequency- A:0.00NS 188
    rs454771931,2
    		C,F--114177395(+) AGAAGC/GTTTTC 1 -- us2k110Minor allele frequency- G:0.09NS WA CSA NA EA 550
    rs1915759681,2
    		--114177424(+) TTGGAC/GAGCTC 1 -- us2k10--------
    rs1414913321,2
    		--114177427(+) GAGAGC/TTCAGG 1 -- us2k10--------
    rs1158681711,2
    		F--114177647(+) GATTCG/TTCTAC 1 -- us2k11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for MARCKS (114178527 - 114184652 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MARCKS: --

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    Disorders / Diseases
    for MARCKS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MARCKS for disorders           About GeneDecksing

    OMIM gene information: 177061    OMIM disorders: --

    20/26 diseases for MARCKS (see all 26):    About MalaCards
    manic-depressive illness    syringoma    small intestine adenocarcinoma    malignant syringoma
    lymphocytic leukemia    chronic lymphocytic leukemia    brain disease    liver cirrhosis
    anoxia    alzheimer's disease    asthma    hepatocellular carcinoma
    leukemia    choroiditis    retinoblastoma    colorectal cancer
    cholangiocarcinoma    melanoma    adenocarcinoma    prostate cancer

    10/17 Novoseek disease relationships for MARCKS gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bipolar disorder 32.2 1 11790517 (1)
    lymphocytic leukemia chronic b-cell 19.5 1 7769846 (1)
    microsatellite instability 18.7 2 19852062 (1), 12140758 (1)
    mania 17.6 1 18789340 (1)
    glioma 15.1 8 8455032 (2), 9150270 (2), 7964753 (2), 8906563 (1) (see all 5)
    brain diseases 4.24 1 10757536 (1)
    asthma 0 1 14716307 (1)
    senile plaques 0 1 10757536 (1)
    necrosis 0 3 9808756 (1), 1860846 (1), 8433016 (1)
    metastasis 0 3 20047593 (2)

    Human Genome Epidemiology (HuGE) Navigator: MARCKS (1 document)

    Export disorders for MARCKS gene to outside databases

    Publications
    for MARCKS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MARCKS gene, integrated from 9 sources (see all 260):
    (articles sorted by number of sources associating them with MARCKS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human myristoylated alanine-rich C kinase substrate (MARCKS) gene (MACS). Analysis of its gene product, promoter, and chromosomal localization. (PubMed id 1860846)1, 2, 9 Harlan D.M.... Blackshear P.J. (1991)
    2. Relationship between the major protein kinase C substrates acidic 80- kDa protein-kinase-C substrate (80K) and myristoylated alanine-rich C- kinase substrate (MARCKS). Members of a gene family or equivalent genes in different species. (PubMed id 1396720)1, 2, 9 Herget T.... Rozengurt E. (1992)
    3. PRK1 phosphorylates MARCKS at the PKC sites: serine 152, serine 156 and serine 163. (PubMed id 8557118)1, 2, 9 Palmer R.H....Parker P.J. (1996)
    4. Molecular cloning and chromosomal mapping of a cDNA encoding human 80K-L protein: major substrate for protein kinase C. (PubMed id 1427823)1, 2, 9 Sakai K.... Shimizu N. (1992)
    5. MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin. (PubMed id 1560845)1, 3, 9 Hartwig J.H....Aderem A. (1992)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    9. The MARCKS family of cellular protein kinase C substr ates. (PubMed id 8420923)1, 3 Blackshear P.J. (1993)
    10. MARCKS regulates lamellipodia formation induced by IG F-I via association with PIP2 and beta-actin at membrane microdomains. (PubMed id 19475567)1, 9 Yamaguchi H....Sasaki Y. (2009)

    External Searches for MARCKS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MARCKS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4082 HGNC: 6759 AceView: MARCKS Ensembl:ENSG00000155130 euGenes: HUgn4082
    ECgene: MARCKS Kegg: 4082 H-InvDB: MARCKS

    Other Databases showing MARCKS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MARCKS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MARCKS Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/marcks/

    Intellectual Property
    for MARCKS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MARCKS gene:
    Search GeneIP for patents involving MARCKS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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