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MARCKS Gene

protein-coding   GIFtS: 62
GCID: GC06P114189

Myristoylated Alanine-Rich Protein Kinase C Substrate

(Previous names: myristoylated alanine-rich protein kinase C substrate (MARCKS,...)
(Previous symbol: MACS)
  Search for MARCKS
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4.2

Aliases
Myristoylated Alanine-Rich Protein Kinase C Substrate1 2     80K-L2
MACS1 2 3 5     Myristoylated Alanine-Rich C-Kinase Substrate2
PKCSL2 3 5     phosphomyristin2
Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS, 80K-L)1 2     80K-L Protein3
Protein Kinase C Substrate, 80 KDa Protein, Light Chain2 3     MRACKS5
PRKCSL2 3     

External Ids:    HGNC: 67591   Entrez Gene: 40822   Ensembl: ENSG000001551307   OMIM: 1770615   UniProtKB: P299663   
ORGUL members:    fRNAdb10:FR036839 FR001258 FR206362      
H-InvDB12:HIT000091557    
NCBI13:BC028284    
NONCODE14:n335522 n342920 n333482    
RNAdb15:EVF20255 EVF20258 HIV1921    

Export aliases for MARCKS gene to outside databases

Previous GC identifers: GC06P114013 GC06P114201 GC06P114224 GC06P114285 GC06P111756 GC06P114179


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MARCKS Gene:
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and
is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin
inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The
protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. (provided
by RefSeq, Jul 2008)

GeneCards Summary for MARCKS Gene:
MARCKS (myristoylated alanine-rich protein kinase C substrate) is a protein-coding gene. GO annotations related to this gene include protein kinase C binding and calmodulin binding.

UniProtKB/Swiss-Prot: MARCS_HUMAN, P29966
Function: MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin,
actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein

Gene Wiki entry for MARCKS Gene

fRNAdb sequence ontologies for MARCKS - the ORGUL cluster for this gene includes several descriptions:
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for MARCKS

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MARCKS gene promoter:
         GATA-3   AP-1   ATF-2   MyoD   GATA-1   YY1   GATA-2   FOXO4   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMARCKS promoter sequence
   Search Chromatin IP Primers for MARCKS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARCKS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.2   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

MARCKS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCKS gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P114189:  view genomic region     (about GC identifiers)

Start:
114,178,527 bp from pter      End:
114,184,652 bp from pter
Size:
6,126 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MARCKS

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MARCS_HUMAN, P29966 (See protein sequence)
Recommended Name: Myristoylated alanine-rich C-kinase substrate  
Size: 332 amino acids; 31555 Da
Secondary accessions: E1P560 Q2LA83 Q5TDB7

Explore the universe of human proteins at neXtProt for MARCKS: NX_P29966

Explore proteomics data for MARCKS at MOPED

Post-translational modifications: 

  • Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity1
  • Ubiquitination2 at Lys165
  • Modification sites at PhosphoSitePlus

  • See MARCKS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002347.5  
    ENSEMBL proteins: 
     ENSP00000357624  
    Reactome Protein details: P29966

    MARCKS Human Recombinant Protein Products:

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    Novus Biologicals MARCKS Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MARCKS

     
    Search eBioscience for Proteins for MARCKS 

    MARCKS Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MARCKS
    R&D Systems Antibodies for MARCKS
    Cell Signaling Technology (CST) Antibodies for MARCKS 
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    OriGene Custom Antibody Services for MARCKS
    Novus Biologicals MARCKS Antibodies
    Abcam antibodies for MARCKS
    Cloud-Clone Corp. Antibodies for MARCKS
    ThermoFisher Antibodies for MARCKS
    LSBio Antibodies in human, mouse, rat for MARCKS

    MARCKS Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MARCKS
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MARCKS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MARCKS
    Cloud-Clone Corp. CLIAs for MARCKS
    Search eBioscience for ELISAs for MARCKS 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002101 MARCKS

    Graphical View of Domain Structure for InterPro Entry P29966

    ProtoNet protein and cluster: P29966

    1 Blocks protein domain: IPB002101 Myristoylated alanine-rich C-kinase substrate MARCKS

    UniProtKB/Swiss-Prot: MARCS_HUMAN, P29966
    Similarity: Belongs to the MARCKS family


    Find genes that share domains with MARCKS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARCS_HUMAN, P29966
    Function: MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin,
    actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding IEA--
    GO:0005515protein binding ----
    GO:0005516calmodulin binding IEA--
    GO:0051015actin filament binding TAS1560845
         
    Find genes that share ontologies with MARCKS           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MARCKS:
     Decreased cilium length after  

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Marcks):
     behavior/neurological  craniofacial  embryogenesis  growth/size/body  mortality/aging 
     nervous system  skeleton  vision/eye 

    Find genes that share phenotypes with MARCKS           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Marckstm1Pjb for MARCKS

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MARCKS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MARCKS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARCKS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARCKS

    miRNA
    Products:
        
    miRTarBase miRNAs that target MARCKS:
    hsa-mir-122-5p (MIRT023285), hsa-mir-15b-5p (MIRT046418), hsa-mir-877-5p (MIRT037313), hsa-mir-1 (MIRT023806), hsa-mir-21-5p (MIRT001221), hsa-mir-155-5p (MIRT020762)

    Block miRNA regulation of human, mouse, rat MARCKS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MARCKS (see all 115):
    hsa-miR-579 hsa-miR-300 hsa-miR-188-5p hsa-miR-128 hsa-miR-4315 hsa-miR-30d hsa-miR-30a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidMARCKS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MARCKS
    Predesigned siRNA for gene silencing in human, mouse, rat MARCKS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MARCKS

    Clone
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    OriGene clones in human, mouse for MARCKS (see all 6)
    OriGene ORF clones in mouse, rat for MARCKS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MARCKS (NM_002356)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCKS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCKS

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MARCKS 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCKS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MARCS_HUMAN, P29966: Cytoplasm, cytoskeleton (Probable). Membrane; Lipid-anchor (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    plasma membrane4
    nucleus3
    cytosol2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005813centrosome IEA--
    GO:0005886plasma membrane TAS--
    GO:0005938cell cortex IEA--
    GO:0015629actin cytoskeleton TAS1560845

    Find genes that share ontologies with MARCKS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MARCKS About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Integration of energy metabolism
    Integration of energy metabolism0.75
    Regulation of Insulin Secretion by Acetylcholine0.00
    Regulation of Insulin Secretion0.75
    2Metabolism
    Metabolism0.38
    3MicroRNAs in cancer
    MicroRNAs in cancer
    4Fc gamma R-mediated phagocytosis
    Fc gamma R-mediated phagocytosis
    5Ca, cAMP and Lipid Signaling
    Ca, cAMP and Lipid Signaling


    Find genes that share SuperPaths with MARCKS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MARCKS
        Ca, cAMP and Lipid Signaling

    1 BioSystems Pathway for MARCKS
        BDNF signaling pathway

    1 Reactome Pathway for MARCKS
        Acetylcholine regulates insulin secretion


    2 Kegg Pathways  (Kegg details for MARCKS):
        Fc gamma R-mediated phagocytosis
    MicroRNAs in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MARCKS
    Interactions:

        GeneGlobe Interaction Network for MARCKS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for MARCKS (P299663 ENSP000003576244) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=3 STRING: ENSP00000349467
    CALM2P621583, ENSP000002722984I2D: score=3 STRING: ENSP00000272298
    CALM3P621583I2D: score=3 
    NMT1P304193, ENSP000002589604I2D: score=3 STRING: ENSP00000258960
    TOB1P506163, ENSP000002689574I2D: score=3 STRING: ENSP00000268957
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0050796regulation of insulin secretion TAS--

    Find genes that share ontologies with MARCKS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MARCKS (MARCS)

    Selected Novoseek inferred chemical compound relationships for MARCKS gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pkcs 64.1 6 7989336 (1), 8601451 (1), 8519597 (1), 18296509 (1)
    pip2 63.5 15 19475567 (4), 9259558 (2), 15052337 (2), 16689643 (1) (see all 6)
    1,2-diacylglycerol 62.8 1 15788407 (1)
    fasudil 53.5 2 19475567 (1)
    phorbol 51.6 7 8627336 (2), 9150270 (2), 9990296 (1), 8437859 (1) (see all 5)
    bisindolylmaleimide 51.3 5 9990296 (1), 9150270 (1)
    phosphatidylserine 47.9 11 8611023 (3), 7840634 (1), 8486722 (1)
    myristic acid 45 1 8702537 (1)
    gf 109203x 41.8 3 7931322 (1), 18768137 (1)
    phosphatidylcholine 39.8 26 9601059 (5), 8627336 (4), 8906563 (2), 8486722 (2) (see all 7)



    Find genes that share compounds with MARCKS           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    3 fRNAdb Secondary structures:


    REFSEQ mRNAs for MARCKS gene: 
    NM_002356.5  

    Unigene Cluster for MARCKS:

    Myristoylated alanine-rich protein kinase C substrate
    Hs.519909  [show with all ESTs]
    Unigene Representative Sequence: NM_002356
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368635(uc003pvy.4)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MARCKS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MARCKS (see all 115):
    hsa-miR-579 hsa-miR-300 hsa-miR-188-5p hsa-miR-128 hsa-miR-4315 hsa-miR-30d hsa-miR-30a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidMARCKS 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MARCKS
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    GenScript: all cDNA clones in your preferred vector: MARCKS (NM_002356)
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    Primer
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    OriGene qPCR primer pairs and template standards for MARCKS
    OriGene qSTAR qPCR primer pairs in human, mouse for MARCKS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARCKS
      QuantiTect SYBR Green Assays in human, mouse, rat MARCKS
      QuantiFast Probe-based Assays in human, mouse, rat MARCKS

    Additional mRNA sequence: 

    AB020968.1 AK027274.1 AL117624.1 BC013004.2 BC028284.1 BC039492.1 BC068059.1 BC089040.1 
    D10522.1 M68956.1 

    16 DOTS entries:

    DT.95363577  DT.87018078  DT.97859974  DT.100823567  DT.100823579  DT.95097816  DT.99957146  DT.121347813 
    DT.95363569  DT.100823570  DT.86843252  DT.95313883  DT.99948747  DT.100038821  DT.95073736  DT.95363579 

    Selected AceView cDNA sequences (see all 585):

    AI039810 AA332063 AA045925 BU678392 BI496575 W79596 BQ018158 AA896967 
    AI278899 BU628623 AA953519 H41031 BF447244 AI318102 AA348702 BF114873 
    AI829778 AA328983 H26445 AA187486 AW003677 AI076187 BU686839 N45033 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MARCKS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTGTAAAT
    MARCKS Expression
    About this image


    MARCKS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Bone (Muscoskeletal System)
             Bone Marrow
    MARCKS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MARCKS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.519909
        Custom PCR Arrays for MARCKS
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MARCKS
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    QuantiFast Probe-based Assays in human, mouse, rat MARCKS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCKS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MARCKS gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Marcks5 myristoylated alanine rich protein kinase C substrate   --   10 (19.49 cM) 37133375 
    lizard
    (Anolis carolinensis)
    Reptilia MARCKS6
    myristoylated alanine-rich protein kinase C substr...
    56(a)
    1 ↔ 1
    1(187719515-187724037)
    African clawed frog
    (Xenopus laevis)
    Amphibia marcks-prov2 myristoylated alanine rich protein kinase C substrate 85.5(n)    AF017299.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AL716290.12   -- 74.5(n)    AL716290.1 


    ENSEMBL Gene Tree for MARCKS (if available)
    TreeFam Gene Tree for MARCKS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MARCKS (see all 165)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs737685671,2
    C,F--114176771(+) TTTCAG/AGTTGG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1403432571,2
    C--114176983(+) ACAATA/GTTCAG 1 -- us2k10--------
    rs1454095341,2
    C--114177098(+) AAACTA/GTTTGA 1 -- us2k10--------
    rs1381421281,2
    C--114177244(+) TTTGGA/GAAGAA 1 -- us2k10--------
    rs1426398611,2
    --114177329(+) AAAAGC/TGTCTG 1 -- us2k10--------
    rs455682311,2
    C,F--114177371(+) TGGAGG/ATATCC 1 -- us2k15Minor allele frequency- A:0.00NS 188
    rs454771931,2
    C,F--114177395(+) AGAAGC/GTTTTC 1 -- us2k110Minor allele frequency- G:0.09NS WA CSA NA EA 550
    rs1915759681,2
    --114177424(+) TTGGAC/GAGCTC 1 -- us2k10--------
    rs1414913321,2
    --114177427(+) GAGAGC/TTCAGG 1 -- us2k10--------
    rs1158681711,2
    F--114177647(+) GATTCG/TTCTAC 1 -- us2k11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for MARCKS (114178527 - 114184652 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MARCKS:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv482098CNV Loss20164927

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MARCKS
    DNA2.0 Custom Variant and Variant Library Synthesis for MARCKS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 177061OMIM information: 122550 143400 604519 608545    

    Find genes that share disorders with MARCKS           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MARCKS gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bipolar disorder 32.2 1 11790517 (1)
    lymphocytic leukemia chronic b-cell 19.5 1 7769846 (1)
    microsatellite instability 18.7 2 19852062 (1), 12140758 (1)
    mania 17.6 1 18789340 (1)
    glioma 15.1 8 8455032 (2), 9150270 (2), 7964753 (2), 8906563 (1) (see all 5)
    brain diseases 4.24 1 10757536 (1)
    asthma 0 1 14716307 (1)
    senile plaques 0 1 10757536 (1)
    necrosis 0 3 9808756 (1), 1860846 (1), 8433016 (1)
    metastasis 0 3 20047593 (2)

    Human Genome Epidemiology (HuGE) Navigator: MARCKS (1 document)

    Export disorders for MARCKS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MARCKS gene, integrated from 10 sources (see all 274):
    (articles sorted by number of sources associating them with MARCKS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human myristoylated alanine-rich C kinase substrate (MARCKS) gene (MACS). Analysis of its gene product, promoter, and chromosomal localization. (PubMed id 1860846)1, 2, 9 Harlan D.M.... Blackshear P.J. (J. Biol. Chem. 1991)
    2. Relationship between the major protein kinase C substrates acidic 80- kDa protein-kinase-C substrate (80K) and myristoylated alanine-rich C- kinase substrate (MARCKS). Members of a gene family or equivalent genes in different species. (PubMed id 1396720)1, 2, 9 Herget T.... Rozengurt E. (Eur. J. Biochem. 1992)
    3. PRK1 phosphorylates MARCKS at the PKC sites: serine 152, serine 156 and serine 163. (PubMed id 8557118)1, 2, 9 Palmer R.H....Parker P.J. (FEBS Lett. 1996)
    4. Molecular cloning and chromosomal mapping of a cDNA encoding human 80K-L protein: major substrate for protein kinase C. (PubMed id 1427823)1, 2, 9 Sakai K.... Shimizu N. (Genomics 1992)
    5. MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin. (PubMed id 1560845)1, 3, 9 Hartwig J.H....Aderem A. (Nature 1992)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    9. The MARCKS family of cellular protein kinase C substrates. (PubMed id 8420923)1, 3 Blackshear P.J. (J. Biol. Chem. 1993)
    10. MARCKS regulates lamellipodia formation induced by IGF-I via association with PIP2 and beta-actin at membrane microdomains. (PubMed id 19475567)1, 9 Yamaguchi H....Sasaki Y. (J. Cell. Physiol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4082 HGNC: 6759 AceView: MARCKS Ensembl:ENSG00000155130 euGenes: HUgn4082
    ECgene: MARCKS Kegg: 4082 H-InvDB: MARCKS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MARCKS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MARCKS Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/marcks/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MARCKS gene:
    Search GeneIP for patents involving MARCKS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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