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Aliases for MARCH9 Gene

Aliases for MARCH9 Gene

  • Membrane Associated Ring-CH-Type Finger 9 2 3 5
  • Membrane-Associated Ring Finger (C3HC4) 9 2 3
  • Membrane-Associated RING Finger Protein 9 3 4
  • Membrane-Associated RING-CH Protein IX 3 4
  • RING Finger Protein 179 3 4
  • MARCH-IX 3 4
  • RNF179 3 4
  • Membrane Associated Ring Finger 9 3
  • EC 6.3.2.- 4

External Ids for MARCH9 Gene

Previous GeneCards Identifiers for MARCH9 Gene

  • GC12P056437
  • GC12P058149
  • GC12P055185

Summaries for MARCH9 Gene

Entrez Gene Summary for MARCH9 Gene

  • MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Hoer et al., 2007 [PubMed 17174307]).[supplied by OMIM, Apr 2010]

GeneCards Summary for MARCH9 Gene

MARCH9 (Membrane Associated Ring-CH-Type Finger 9) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is MARCH11.

UniProtKB/Swiss-Prot for MARCH9 Gene

  • E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH9 Gene

Genomics for MARCH9 Gene

Regulatory Elements for MARCH9 Gene

Enhancers for MARCH9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MARCH9 on UCSC Golden Path with GeneCards custom track

Genomic Location for MARCH9 Gene

57,753,622 bp from pter
57,760,410 bp from pter
6,789 bases
Plus strand

Genomic View for MARCH9 Gene

Genes around MARCH9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCH9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCH9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH9 Gene

Proteins for MARCH9 Gene

  • Protein details for MARCH9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase MARCH9
    Protein Accession:
    Secondary Accessions:
    • B2R9U9
    • Q86VN5
    • Q96GG2

    Protein attributes for MARCH9 Gene

    346 amino acids
    Molecular mass:
    37772 Da
    Quaternary structure:
    • Homodimer.
    • Sequence=AAH50397.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MARCH9 Gene


neXtProt entry for MARCH9 Gene

Proteomics data for MARCH9 Gene at MOPED

Post-translational modifications for MARCH9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MARCH9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MARCH9 Gene

Domains & Families for MARCH9 Gene

Protein Domains for MARCH9 Gene

Graphical View of Domain Structure for InterPro Entry



  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
  • Contains 1 RING-CH-type zinc finger.
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
  • Contains 1 RING-CH-type zinc finger.
genes like me logo Genes that share domains with MARCH9: view

No data available for Suggested Antigen Peptide Sequences for MARCH9 Gene

Function for MARCH9 Gene

Molecular function for MARCH9 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for MARCH9 Gene

genes like me logo Genes that share phenotypes with MARCH9: view

Animal Models for MARCH9 Gene

MGI Knock Outs for MARCH9:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MARCH9 Gene

Localization for MARCH9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCH9 Gene

Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MARCH9 Gene COMPARTMENTS Subcellular localization image for MARCH9 gene
Compartment Confidence
golgi apparatus 5
lysosome 4
vacuole 3
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MARCH9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005795 Golgi stack IDA 14722266
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MARCH9: view

Pathways & Interactions for MARCH9 Gene

SuperPathways for MARCH9 Gene

No Data Available

UniProtKB/Swiss-Prot Q86YJ5-MARH9_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MARCH9 Gene


No data available for Pathways by source and SIGNOR curated interactions for MARCH9 Gene

Drugs & Compounds for MARCH9 Gene

(4) Drugs for MARCH9 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Somatropin recombinant Approved, Investigational Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for MARCH9 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
genes like me logo Genes that share compounds with MARCH9: view

Transcripts for MARCH9 Gene

Unigene Clusters for MARCH9 Gene

Membrane-associated ring finger (C3HC4) 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH9 Gene

No ASD Table

Relevant External Links for MARCH9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MARCH9 Gene

mRNA expression in normal human tissues for MARCH9 Gene

Protein differential expression in normal tissues from HIPED for MARCH9 Gene

This gene is overexpressed in Rectum (25.7), Heart (16.5), and Adipocyte (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MARCH9 Gene

SOURCE GeneReport for Unigene cluster for MARCH9 Gene Hs.632709

mRNA Expression by UniProt/SwissProt for MARCH9 Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with MARCH9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for MARCH9 Gene

Orthologs for MARCH9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCH9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MARCH9 35
  • 94.03 (n)
  • 96.82 (a)
  • 97 (a)
(Canis familiaris)
Mammalia MARCH9 35
  • 95.58 (n)
  • 97.86 (a)
  • 98 (a)
(Mus musculus)
Mammalia March9 35
  • 91.81 (n)
  • 95.66 (a)
March9 16
March9 36
  • 95 (a)
(Pan troglodytes)
Mammalia MARCH9 35
  • 99.61 (n)
  • 99.42 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia March9 35
  • 92.1 (n)
  • 95.66 (a)
(Monodelphis domestica)
Mammalia MARCH9 36
  • 89 (a)
(Anolis carolinensis)
Reptilia MARCH9 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia march9 35
  • 70.93 (n)
  • 76.83 (a)
(Danio rerio)
Actinopterygii march9 35
  • 70.42 (n)
  • 70.82 (a)
march9 36
  • 68 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
Species with no ortholog for MARCH9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARCH9 Gene

Gene Tree for MARCH9 (if available)
Gene Tree for MARCH9 (if available)

Paralogs for MARCH9 Gene

Paralogs for MARCH9 Gene

(2) SIMAP similar genes for MARCH9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MARCH9: view

Variants for MARCH9 Gene

Sequence variations from dbSNP and Humsavar for MARCH9 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs17856312 - 57,758,627(+) AACCA(G/T)CAGTG reference, missense
rs17850517 - 57,758,775(+) TGCGG(A/C)CGCTC reference, missense
rs35101706 -- 57,757,207(+) GTTAC(-/CA)CAGTC intron-variant
rs2518691 -- 57,755,559(+) TTCTG(A/G)ACGAG reference, missense
rs1048691 -- 57,759,165(+) CCTTC(C/T)CTGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MARCH9 Gene

Variant ID Type Subtype PubMed ID
nsv899121 CNV Loss 21882294
nsv470296 CNV Loss 18288195
nsv899123 CNV Loss 21882294
nsv826384 CNV Gain 20364138
nsv510601 CNV Loss 20534489
nsv470297 CNV Gain 18288195
nsv826386 CNV Gain 20364138

Variation tolerance for MARCH9 Gene

Residual Variation Intolerance Score: 52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MARCH9 Gene

Disorders for MARCH9 Gene

Relevant External Links for MARCH9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MARCH9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MARCH9 Gene

Publications for MARCH9 Gene

  1. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E. … Frueh K. (J. Virol. 2004) 2 3 4 23 67
  2. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  3. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3
  5. Stress-regulated targeting of the NKG2D ligand Mult1 by a membrane-associated RING-CH family E3 ligase. (PMID: 20870941) Nice T.J. … Raulet D.H. (J. Immunol. 2010) 3

Products for MARCH9 Gene

Sources for MARCH9 Gene