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Aliases for MARCH9 Gene

Aliases for MARCH9 Gene

  • Membrane-Associated Ring Finger (C3HC4) 9 2 3
  • Membrane-Associated RING Finger Protein 9 3 4
  • Membrane-Associated RING-CH Protein IX 3 4
  • RING Finger Protein 179 3 4
  • MARCH-IX 3 4
  • RNF179 3 4
  • E3 Ubiquitin-Protein Ligase MARCH9 3
  • EC 6.3.2.- 4

External Ids for MARCH9 Gene

Previous GeneCards Identifiers for MARCH9 Gene

  • GC12P056437
  • GC12P058149
  • GC12P055185

Summaries for MARCH9 Gene

Entrez Gene Summary for MARCH9 Gene

  • MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Hoer et al., 2007 [PubMed 17174307]).[supplied by OMIM, Apr 2010]

GeneCards Summary for MARCH9 Gene

MARCH9 (Membrane-Associated Ring Finger (C3HC4) 9) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is MARCH11.

UniProtKB/Swiss-Prot for MARCH9 Gene

  • E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH9 Gene

Genomics for MARCH9 Gene

Regulatory Elements for MARCH9 Gene

Genomic Location for MARCH9 Gene

Start:
57,755,098 bp from pter
End:
57,760,410 bp from pter
Size:
5,313 bases
Orientation:
Plus strand

Genomic View for MARCH9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARCH9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH9 Gene

Proteins for MARCH9 Gene

  • Protein details for MARCH9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YJ5-MARH9_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MARCH9
    Protein Accession:
    Q86YJ5
    Secondary Accessions:
    • B2R9U9
    • Q86VN5
    • Q96GG2

    Protein attributes for MARCH9 Gene

    Size:
    346 amino acids
    Molecular mass:
    37772 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAH50397.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MARCH9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARCH9 Gene

Proteomics data for MARCH9 Gene at MOPED

Post-translational modifications for MARCH9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MARCH9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MARCH9 Gene

Domains for MARCH9 Gene

Gene Families for MARCH9 Gene

HGNC:
  • MARCH :MARCH membrane-associated ring fingers
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for MARCH9 Gene

Graphical View of Domain Structure for InterPro Entry

Q86YJ5

UniProtKB/Swiss-Prot:

MARH9_HUMAN :
  • Q86YJ5
Domain:
  • The RING-CH-type zinc finger domain is required for E3 ligase activity
Similarity:
  • Contains 1 RING-CH-type zinc finger.
genes like me logo Genes that share domains with MARCH9: view

No data available for Suggested Antigen Peptide Sequences for MARCH9 Gene

Function for MARCH9 Gene

Molecular function for MARCH9 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for MARCH9 Gene

Gene Ontology (GO) - Molecular Function for MARCH9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with MARCH9: view
genes like me logo Genes that share phenotypes with MARCH9: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MARCH9 Gene

Localization for MARCH9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCH9 Gene

Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MARCH9 Gene COMPARTMENTS Subcellular localization image for MARCH9 gene
Compartment Confidence
golgi apparatus 5
lysosome 5
vacuole 5
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MARCH9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005764 lysosome --
GO:0005765 lysosomal membrane IEA --
GO:0005795 Golgi stack IDA 14722266
GO:0005802 trans-Golgi network IDA 14722266
genes like me logo Genes that share ontologies with MARCH9: view

Pathways for MARCH9 Gene

SuperPathways for MARCH9 Gene

No Data Available

UniProtKB/Swiss-Prot Q86YJ5-MARH9_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for MARCH9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MARCH9: view

No data available for Pathways by source for MARCH9 Gene

Compounds for MARCH9 Gene

(4) HMDB Compounds for MARCH9 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(1) PharmGKB related drug/compound annotations for MARCH9 Gene

Drug/compound Annotation
somatropin recombinant CA
genes like me logo Genes that share compounds with MARCH9: view

Transcripts for MARCH9 Gene

Unigene Clusters for MARCH9 Gene

Membrane-associated ring finger (C3HC4) 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH9 Gene

No ASD Table

Relevant External Links for MARCH9 Gene

GeneLoc Exon Structure for
MARCH9
ECgene alternative splicing isoforms for
MARCH9

Expression for MARCH9 Gene

mRNA expression in normal human tissues for MARCH9 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MARCH9 Gene

SOURCE GeneReport for Unigene cluster for MARCH9 Gene Hs.632709

mRNA Expression by UniProt/SwissProt for MARCH9 Gene

Q86YJ5-MARH9_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with MARCH9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MARCH9 Gene

Orthologs for MARCH9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCH9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARCH9 35
  • 99.61 (n)
  • 99.42 (a)
MARCH9 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MARCH9 35
  • 94.03 (n)
  • 96.82 (a)
MARCH9 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MARCH9 35
  • 95.58 (n)
  • 97.86 (a)
MARCH9 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia March9 35
  • 91.81 (n)
  • 95.66 (a)
March9 16
March9 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MARCH9 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia March9 35
  • 92.1 (n)
  • 95.66 (a)
lizard
(Anolis carolinensis)
Reptilia MARCH9 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia march9 35
  • 70.93 (n)
  • 76.83 (a)
zebrafish
(Danio rerio)
Actinopterygii march9 35
  • 70.42 (n)
  • 70.82 (a)
march9 36
  • 68 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for MARCH9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARCH9 Gene

ENSEMBL:
Gene Tree for MARCH9 (if available)
TreeFam:
Gene Tree for MARCH9 (if available)

Paralogs for MARCH9 Gene

Paralogs for MARCH9 Gene

Selected SIMAP similar genes for MARCH9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MARCH9: view

Variants for MARCH9 Gene

Sequence variations from dbSNP and Humsavar for MARCH9 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1048691 -- 57,759,165(+) CCTTC(C/T)CTGGA utr-variant-3-prime
rs1689582 -- 57,755,663(-) GAGCA(A/G)CCAGC reference, synonymous-codon
rs2518691 -- 57,755,559(+) TTCTG(A/G)ACGAG reference, missense
rs2640604 -- 57,756,733(+) ATGGG(A/G)AGTTT intron-variant
rs2650059 -- 57,756,094(-) GGAGA(A/G)AGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH9 Gene

Variant ID Type Subtype PubMed ID
nsv899121 CNV Loss 21882294
nsv470296 CNV Loss 18288195
nsv899123 CNV Loss 21882294
nsv826384 CNV Gain 20364138
nsv510601 CNV Loss 20534489
nsv470297 CNV Gain 18288195
nsv826386 CNV Gain 20364138

Relevant External Links for MARCH9 Gene

HapMap Linkage Disequilibrium report
MARCH9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH9 Gene

Disorders for MARCH9 Gene

Relevant External Links for MARCH9

Genetic Association Database (GAD)
MARCH9
Human Genome Epidemiology (HuGE) Navigator
MARCH9
genes like me logo Genes that share disorders with MARCH9: view

No data available for UniProtKB/Swiss-Prot for MARCH9 Gene

Publications for MARCH9 Gene

  1. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E. … Frueh K. (J. Virol. 2004) 2 3 4 23
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. MARCH-IX mediates ubiquitination and downregulation of ICAM-1. (PMID: 17174307) Hoer S. … Lehner P.J. (FEBS Lett. 2007) 3 4

Products for MARCH9 Gene

Sources for MARCH9 Gene

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