Aliases for MARCH9 Gene
External Ids for MARCH9 Gene
Previous GeneCards Identifiers for MARCH9 Gene
MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 220.127.116.11). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Hoer et al., 2007 [PubMed 17174307]).[supplied by OMIM, Apr 2010]
GeneCards Summary for MARCH9 Gene
MARCH9 (Membrane Associated Ring-CH-Type Finger 9) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is MARCH11.
UniProtKB/Swiss-Prot for MARCH9 Gene
E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.