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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MARCH9 Gene

protein-coding   GIFtS: 47
GCID: GC12P058149

Membrane-Associated Ring Finger (C3HC4) 9

Microbiology & Infectious Diseases Congress
  Search for MARCH9
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Membrane-Associated Ring Finger (C3HC4) 91 2     RNF1792 3
Membrane-Associated RING Finger Protein 92 3     RING Finger Protein 1792 3
Membrane-Associated RING-CH Protein IX2 3     E3 Ubiquitin-Protein Ligase MARCH92
MARCH-IX2 3     EC 6.3.2.-3

External Ids:    HGNC: 251391   Entrez Gene: 929792   Ensembl: ENSG000001392667   OMIM: 6133365   UniProtKB: Q86YJ53   

Export aliases for MARCH9 gene to outside databases

Previous GC identifers: GC12P056437 GC12P055185


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MARCH9 Gene:
MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add
ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport
between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them
to the endosomal compartment (Bartee et al., 2004 (PubMed 14722266); Hoer et al., 2007 (PubMed
17174307)).(supplied by OMIM, Apr 2010)

GeneCards Summary for MARCH9 Gene: 
MARCH9 (membrane-associated ring finger (C3HC4) 9) is a protein-coding gene. GO annotations related to this gene include zinc ion binding and ligase activity. An important paralog of this gene is MARCH11.

UniProtKB/Swiss-Prot: MARH9_HUMAN, Q86YJ5
Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their
subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin
from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to
targeted substrates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MARCH9 gene promoter:
         E2F-3a   E2F-4   E2F-5   AP-1   ATF-2   E2F-2   C/EBPalpha   E2F   E2F-1   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MARCH9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARCH9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.1   Ensembl cytogenetic band:  12q14.1   HGNC cytogenetic band: 12q14.1

MARCH9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCH9 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P058149:  view genomic region     (about GC identifiers)

Start:
58,148,881 bp from pter      End:
58,154,190 bp from pter
Size:
5,310 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MARH9_HUMAN, Q86YJ5 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MARCH9  
Size: 346 amino acids; 37772 Da
Subunit: Homodimer
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass
membrane protein
Sequence caution: Sequence=AAH50397.1; Type=Erroneous initiation;
Secondary accessions: B2R9U9 Q86VN5 Q96GG2
Alternative splicing: 2 isoforms:  Q86YJ5-1   Q86YJ5-2   (Has no E3 activity due to lack of RINGv-type zinc finger domain but is able to dimerize with and stabilize isoform 1)

Explore the universe of human proteins at neXtProt for MARCH9: NX_Q86YJ5

Explore proteomics data for MARCH9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86YJ5

  • MARCH9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MARCH9 Protein Expression
    REFSEQ proteins: NP_612405.2  
    ENSEMBL proteins: 
     ENSP00000266643   ENSP00000446758  

    Human Recombinant Protein Products for MARCH9: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MARCH9
    OriGene Custom MassSpec 
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    GenScript Custom Purified and Recombinant Proteins Services for MARCH9
    Novus Biologicals MARCH9 Proteins
    Novus Biologicals MARCH9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005765lysosomal membrane IEA--
    GO:0005795Golgi stack IDA14722266
    GO:0005802trans-Golgi network IDA14722266
    GO:0016021integral to membrane IEA--

    MARCH9 for ontologies           About GeneDecksing



    MARCH9 Antibody Products: 
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    Novus Biologicals MARCH9 Antibodies
    Abcam antibodies for MARCH9
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    LSBio Antibodies in human, mouse, rat for MARCH9 

    Assay Products for MARCH9: 
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    GenScript Custom Assay Services for MARCH9
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers
    MARCH: MARCH membrane-associated ring fingers

    2 InterPro protein domains:
     IPR013083 Znf_RING/FYVE/PHD
     IPR011016 Znf_RING-CH

    Graphical View of Domain Structure for InterPro Entry Q86YJ5

    ProtoNet protein and cluster: Q86YJ5

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB011016 RINGv


    UniProtKB/Swiss-Prot: MARH9_HUMAN, Q86YJ5
    Domain: The RING-CH-type zinc finger domain is required for E3 ligase activity
    Similarity: Contains 1 RING-CH-type zinc finger


    MARCH9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARH9_HUMAN, Q86YJ5
    Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their
    subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin
    from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to
    targeted substrates

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    MARCH9 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for March9):
     behavior/neurological  growth/size  homeostasis/metabolism  other  skeleton 

    MARCH9 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MARCH9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MARCH9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARCH9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARCH9 

    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate MARCH9 (see all 28):
    hsa-miR-1226 hsa-miR-448 hsa-miR-146b-3p hsa-miR-4254 hsa-miR-137 hsa-let-7d hsa-miR-202 hsa-miR-944
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript Custom all cDNA clones Services for MARCH9
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH9
    Sirion Biotech Customized lentivirus for stable overexpression of MARCH9 
                         Customized lentivirus expression plasmids for stable overexpression of MARCH9 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MARCH9
    Search LifeMap BioReagents cell lines for MARCH9
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: MARH9_HUMAN, Q86YJ5
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MARCH9

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for MARCH9 (Q86YJ52, 3 ENSP000002666434) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTSDP073392, 3, ENSP000002366714MINT-4053134 I2D: score=1 STRING: ENSP00000236671
    MARCH9Q86YJ52MINT-4053171 MINT-4053190
    --P310162MINT-8106847
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    MARCH9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MARCH9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MARCH9 (MARH9)

    4 HMDB Compounds for MARCH9    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 PharmGKB related drug/compound annotation for MARCH9 gene    About this table
    Drug/compound PharmGKB Annotation
    somatropin recombinantCA  

    Search CenterWatch for drugs/clinical trials and news about MARCH9 / MARH9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MARCH9 gene: 
    NM_138396.5  

    Unigene Cluster for MARCH9:

    Membrane-associated ring finger (C3HC4) 9
    Hs.632709  [show with all ESTs]
    Unigene Representative Sequence: NM_138396
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266643(uc001spx.2 uc001spy.3) ENST00000552279 ENST00000548358

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARCH9
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate MARCH9 (see all 28):
    hsa-miR-1226 hsa-miR-448 hsa-miR-146b-3p hsa-miR-4254 hsa-miR-137 hsa-let-7d hsa-miR-202 hsa-miR-944
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MARCH9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARCH9
    Clone
    Products:
         
    OriGene clones in human, mouse for MARCH9 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MARCH9
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH9
    Sirion Biotech Customized lentivirus for stable overexpression of MARCH9 
                         Customized lentivirus expression plasmids for stable overexpression of MARCH9 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MARCH9
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    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MARCH9
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARCH9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARCH9

    Additional mRNA sequence: 

    AK093897.1 AK313925.1 BC009489.2 BC036455.2 BC050397.1 

    5 DOTS entries:

    DT.97781345  DT.310310  DT.95226898  DT.121198927  DT.97837435 

    24/130 AceView cDNA sequences (see all 130):

    AI197883 BF058623 BG289916 BM714083 AI128462 BQ671275 BU688571 AI418735 
    BU955989 BQ674141 BM724774 AI452933 AI052798 AI857500 AX748358 BI766318 
    BC050397 AI275408 AI540154 AA045479 BE047912 AI859999 BQ029756 BM675267 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MARCH9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGAAGGGC
    MARCH9 Expression
    About this image


    See MARCH9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MARCH9

    SOURCE GeneReport for Unigene cluster: Hs.632709

    UniProtKB/Swiss-Prot: MARH9_HUMAN, Q86YJ5
    Tissue specificity: Ubiquitously expressed

        SABiosciences Custom PCR Arrays for MARCH9
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MARCH9 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia March91 , 5 membrane-associated ring finger (C3HC4) 91, 5 91.81(n)1
    95.66(a)1
      10 (74.50 cM)5
    2164381  NM_001033262.21  NP_001028434.11 
     1270550115 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-229p15.11 si:dkey-229p15.1 73.05(n)
    75.99(a)
      100003493  XM_001339809.4  XP_001339845.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F58E6.126
    Protein F58E6.12
    17(a)
    1 → many
    V(9739666-9740870)


    ENSEMBL Gene Tree for MARCH9 (if available)
    TreeFam Gene Tree for MARCH9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MARCH9 gene
    MARCH112  MARCH42  
    2 SIMAP similar genes for MARCH9 using alignment to 1 protein entry:     MARH9_HUMAN:
    MARCH4    MARCH11

    MARCH9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/131 SNPs in MARCH9 are shown (see all 131)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs787657491,2
    F--58148368(+) CACAGG/TCTTCT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs111723221,2
    C,F,H--58148454(+) TTGGGT/CAAAGT 1 -- us2k18Minor allele frequency- C:0.08NS NA WA 1012
    rs733382451,2
    C,F--58148488(+) TGCCCG/ATGTAC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs777965791,2
    F--58148692(+) ACCCTC/TCTCGG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs733382461,2
    C,F--58148695(+) CTCCTC/TGGGAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs636804631,2
    C--58148721(+) CCCCTG/-GGGAC 1 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs1855194631,2
    --58148739(+) CGTGCA/GGGGCA 1 -- us2k10--------
    rs25186911,2
    C--58149342(+) TTCTGA/GACGAG 2 N D mis10--------
    rs16895821,2
    C,H--58149446(-) GAGCAA/GCCAGC 2 G syn1 ese36Minor allele frequency- G:0.00MN NA 312
    rs1877632291,2
    --58149659(+) CAGGGA/CCCGGA 2 G syn10--------

    HapMap Linkage Disequilibrium report for MARCH9 (58148881 - 58154190 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MARCH9:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv899121CNV Loss21882294
    nsv510601CNV Loss20534489
    nsv899123CNV Loss21882294
    nsv470296CNV Loss18288195
    nsv470297CNV Gain18288195
    nsv826384CNV Gain20364138
    nsv826386CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MARCH9
    DNA2.0 Custom Variant and Variant Library Synthesis for MARCH9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MARCH9 for disorders           About MalaCards
    OMIM gene information: 613336    OMIM disorders: --


    MARCH9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MARCH9
    Human Genome Epidemiology (HuGE) Navigator: MARCH9 (3 documents)

    Export disorders for MARCH9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MARCH9 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MARCH9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PubMed id 14722266)1, 2, 3, 9 Bartee E.... Frueh K. (2004)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. MARCH-IX mediates ubiquitination and downregulation of ICAM-1. (PubMed id 17174307)1, 2 Hoer S.... Lehner P.J. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    7. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)
    8. Stress-regulated targeting of the NKG2D ligand Mult1 by a membrane-associated RING-CH family E3 ligase. (PubMed id 20870941)1 Nice T.J....Raulet D.H. (2010)
    9. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 92979 HGNC: 25139 AceView: MARCH-IX Ensembl:ENSG00000139266 euGenes: HUgn92979
    ECgene: MARCH9 H-InvDB: MARCH9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MARCH9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MARCH9 gene:
    Search GeneIP for patents involving MARCH9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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