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MARCH9 Gene

protein-coding   GIFtS: 44
GCID: GC12P058149

Membrane-Associated Ring Finger (C3HC4) 9

  Search for MARCH9
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Membrane-Associated Ring Finger (C3HC4) 91 2     RNF1792 3
Membrane-Associated RING Finger Protein 92 3     RING Finger Protein 1792 3
Membrane-Associated RING-CH Protein IX2 3     E3 Ubiquitin-Protein Ligase MARCH92
MARCH-IX2 3     EC 6.3.2.-3

External Ids:    HGNC: 251391   Entrez Gene: 929792   Ensembl: ENSG000001392667   OMIM: 6133365   UniProtKB: Q86YJ53   

Export aliases for MARCH9 gene to outside databases

Previous GC identifers: GC12P056437 GC12P055185


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MARCH9 Gene:
MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add
ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport
between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them
to the endosomal compartment (Bartee et al., 2004 (PubMed 14722266); Hoer et al., 2007 (PubMed
17174307)).(supplied by OMIM, Apr 2010)

GeneCards Summary for MARCH9 Gene:
MARCH9 (membrane-associated ring finger (C3HC4) 9) is a protein-coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is MARCH11.

UniProtKB/Swiss-Prot: MARH9_HUMAN, Q86YJ5
Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their
subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin
from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to
targeted substrates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the MARCH9 gene promoter:
         E2F-3a   E2F-4   E2F-5   AP-1   ATF-2   E2F-2   C/EBPalpha   E2F   E2F-1   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MARCH9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARCH9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.1   Ensembl cytogenetic band:  12q14.1   HGNC cytogenetic band: 12q14.1

MARCH9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCH9 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P058149:  view genomic region     (about GC identifiers)

Start:
58,148,881 bp from pter      End:
58,154,190 bp from pter
Size:
5,310 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MARH9_HUMAN, Q86YJ5 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MARCH9  
Size: 346 amino acids; 37772 Da
Subunit: Homodimer
Sequence caution: Sequence=AAH50397.1; Type=Erroneous initiation;
Secondary accessions: B2R9U9 Q86VN5 Q96GG2
Alternative splicing: 2 isoforms:  Q86YJ5-1   Q86YJ5-2   (Has no E3 activity due to lack of RINGv-type zinc finger domain but is able to dimerize with and stabilize isoform 1)

Explore the universe of human proteins at neXtProt for MARCH9: NX_Q86YJ5

Explore proteomics data for MARCH9 at MOPED


See MARCH9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_612405.2  
ENSEMBL proteins: 
 ENSP00000266643   ENSP00000446758  

MARCH9 Human Recombinant Protein Products:

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OriGene Protein Over-expression Lysate for MARCH9
OriGene Custom MassSpec
OriGene Custom Protein Services for MARCH9
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Novus Biologicals MARCH9 Proteins
Novus Biologicals MARCH9 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for MARCH9 

MARCH9 Antibody Products:

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OriGene Custom Antibody Services for MARCH9
Novus Biologicals MARCH9 Antibodies
Search for Antibodies for MARCH9 at Abcam
Browse Antibodies at Cloud-Clone Corp.
Search ThermoFisher Antibodies for MARCH9
Search LSBio for Antibodies for MARCH9

MARCH9 Assay Products:

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Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for MARCH9
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.
Search eBioscience for ELISAs for MARCH9 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
RNF: RING-type (C3HC4) zinc fingers
MARCH: MARCH membrane-associated ring fingers

2 InterPro protein domains:
 IPR013083 Znf_RING/FYVE/PHD
 IPR011016 Znf_RING-CH

Graphical View of Domain Structure for InterPro Entry Q86YJ5

ProtoNet protein and cluster: Q86YJ5

2 Blocks protein domains:
IPB001841 Zn-finger
IPB011016 RINGv


UniProtKB/Swiss-Prot: MARH9_HUMAN, Q86YJ5
Domain: The RING-CH-type zinc finger domain is required for E3 ligase activity
Similarity: Contains 1 RING-CH-type zinc finger


Find genes that share domains with MARCH9           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: MARH9_HUMAN, Q86YJ5
Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their
subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin
from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to
targeted substrates

     Enzyme Number (IUBMB): EC 6.3.2.-1

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008270zinc ion binding IEA--
GO:0016874ligase activity IEA--
GO:0046872metal ion binding ----
     
Find genes that share ontologies with MARCH9           About GenesLikeMe


Phenotypes:
     5 MGI mutant phenotypes (inferred from 1 allele(MGI details for March9):
 behavior/neurological  growth/size/body  homeostasis/metabolism  other  skeleton 

Find genes that share phenotypes with MARCH9           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MARCH9
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MARCH9

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARCH9
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARCH9

miRNA
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Selected qRT-PCR Assays for microRNAs that regulate MARCH9 (see all 28):
hsa-miR-1226 hsa-miR-448 hsa-miR-146b-3p hsa-miR-4254 hsa-miR-137 hsa-let-7d hsa-miR-202 hsa-miR-944
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for MARCH9
Predesigned siRNA for gene silencing in human, mouse, rat MARCH9

Gene Editing
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OriGene clones in human, mouse for MARCH9 (see all 5)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH9
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH9

Cell Line
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GenScript Custom overexpressing Cell Line Services for MARCH9
Browse ESI BIO Cell Lines and PureStem Progenitors for MARCH9 
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH9


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
MARH9_HUMAN, Q86YJ5: Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass
membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
golgi apparatus5
lysosome5
vacuole5
mitochondrion2
cytosol1
endoplasmic reticulum1
extracellular1
plasma membrane1

Gene Ontology (GO): 5 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000139Golgi membrane IEA--
GO:0005765lysosomal membrane IEA--
GO:0005795Golgi stack IDA14722266
GO:0005802trans-Golgi network IDA14722266
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with MARCH9           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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UniProtKB/Swiss-Prot: MARH9_HUMAN, Q86YJ5
Pathway: Protein modification; protein ubiquitination

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MARCH9
Interactions:

    Search GeneGlobe Interaction Network for MARCH9

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for MARCH9 (Q86YJ52, 3 ENSP000002666434) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

InteractantInteraction Details
GeneCardExternal ID(s)
CTSDP073392, 3, ENSP000002366714MINT-4053134 I2D: score=1 STRING: ENSP00000236671
MARCH9Q86YJ52MINT-4053171 MINT-4053190
UBE2G2ENSP000003383484STRING: ENSP00000338348
UBE2J2ENSP000003837194STRING: ENSP00000383719
CSTF3ENSP000003157914STRING: ENSP00000315791
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016567protein ubiquitination IEA--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MARCH9 (MARH9)

4 HMDB Compounds for MARCH9    About this table
CompoundSynonyms CAS #PubMed Ids
Adenosine monophosphate5'-AMP (see all 28)61-19-8--
Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

1 PharmGKB related drug/compound annotation for MARCH9 gene    About this table
Drug/compound PharmGKB Annotation
somatropin recombinantCA  



Find genes that share compounds with MARCH9           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MARCH9 gene: 
NM_138396.5  

Unigene Cluster for MARCH9:

Membrane-associated ring finger (C3HC4) 9
Hs.632709  [show with all ESTs]
Unigene Representative Sequence: NM_138396
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000266643(uc001spx.2 uc001spy.3) ENST00000552279 ENST00000548358

miRNA
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Selected qRT-PCR Assays for microRNAs that regulate MARCH9 (see all 28):
hsa-miR-1226 hsa-miR-448 hsa-miR-146b-3p hsa-miR-4254 hsa-miR-137 hsa-let-7d hsa-miR-202 hsa-miR-944
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for MARCH9
Predesigned siRNA for gene silencing in human, mouse, rat MARCH9
Clone
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OriGene clones in human, mouse for MARCH9 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for MARCH9
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH9
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH9
Primer
Products:
    
OriGene qPCR primer pairs and template standards for MARCH9
OriGene qSTAR qPCR primer pairs in human, mouse for MARCH9
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MARCH9
  QuantiTect SYBR Green Assays in human, mouse, rat MARCH9
  QuantiFast Probe-based Assays in human, mouse, rat MARCH9

Additional mRNA sequence: 

AK093897.1 AK313925.1 BC009489.2 BC036455.2 BC050397.1 

5 DOTS entries:

DT.97781345  DT.310310  DT.95226898  DT.121198927  DT.97837435 

Selected AceView cDNA sequences (see all 130):

BI766318 BQ029756 BG289916 BF438539 BQ671275 AI052798 AK093897 AA045479 
AX748358 AI418735 BM724774 AI128462 AI857500 AI197883 BU688571 AI452933 
BM675267 BU955989 AI275408 BC050397 BF058623 BM714083 AI859999 AI540154 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MARCH9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGGGAAGGGC
MARCH9 Expression
About this image

MARCH9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MARCH9 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.632709

UniProtKB/Swiss-Prot: MARH9_HUMAN, Q86YJ5
Tissue specificity: Ubiquitously expressed

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QuantiFast Probe-based Assays in human, mouse, rat MARCH9
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH9

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MARCH9 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia March91 , 5 membrane-associated ring finger (C3HC4) 91, 5 91.81(n)1
95.66(a)1
  10 (74.50 cM)5
2164381  NM_001033262.21  NP_001028434.11 
 1270550115 
lizard
(Anolis carolinensis)
Reptilia MARCH96
membrane-associated ring finger (C3HC4) 9
66(a)
1 ↔ 1
2(66821412-66821768)
tropical clawed frog
(Xenopus tropicalis)
Amphibia march91 membrane-associated ring finger (C3HC4) 9 70.93(n)
76.83(a)
  100127869  NM_001126078.1  NP_001119550.1 
zebrafish
(Danio rerio)
Actinopterygii march91 membrane-associated ring finger (C3HC4) 9 70.42(n)
70.82(a)
  100003493  XM_001339809.5  XP_001339845.1 


ENSEMBL Gene Tree for MARCH9 (if available)
TreeFam Gene Tree for MARCH9 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MARCH9 gene
MARCH112  MARCH42  
2 SIMAP similar genes for MARCH9 using alignment to 1 protein entry:     MARH9_HUMAN:
MARCH4    MARCH11

Find genes that share paralogs with MARCH9           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MARCH9 (see all 131)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs787657491,2
F--58148368(+) CACAGG/TCTTCT 1 -- us2k11Minor allele frequency- T:0.01WA 118
rs111723221,2
C,F,H--58148454(+) TTGGGT/CAAAGT 1 -- us2k18Minor allele frequency- C:0.08NS NA WA 1012
rs733382451,2
C,F--58148488(+) TGCCCG/ATGTAC 1 -- us2k11Minor allele frequency- A:0.50WA 2
rs777965791,2
F--58148692(+) ACCCTC/TCTCGG 1 -- us2k11Minor allele frequency- T:0.01WA 118
rs733382461,2
C,F--58148695(+) CTCCTC/TGGGAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
rs636804631,2
C--58148721(+) CCCCTG/-GGGAC 1 -- us2k11Minor allele frequency- -:0.00CSA 2
rs1855194631,2
--58148739(+) CGTGCA/GGGGCA 1 -- us2k10--------
rs25186911,2
C--58149342(+) TTCTGA/GACGAG 2 N D mis10--------
rs16895821,2
C,H--58149446(-) GAGCAA/GCCAGC 2 G syn1 ese36Minor allele frequency- G:0.00MN NA 312
rs1877632291,2
--58149659(+) CAGGGA/CCCGGA 2 G syn10--------

HapMap Linkage Disequilibrium report for MARCH9 (58148881 - 58154190 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for MARCH9:    About this table    
Variant IDTypeSubtypePubMed ID
nsv899121CNV Loss21882294
nsv510601CNV Loss20534489
nsv899123CNV Loss21882294
nsv470296CNV Loss18288195
nsv470297CNV Gain18288195
nsv826384CNV Gain20364138
nsv826386CNV Gain20364138

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MARCH9
DNA2.0 Custom Variant and Variant Library Synthesis for MARCH9

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 613336    OMIM disorders: --


Find genes that share disorders with MARCH9           About GenesLikeMe

Genetic Association Database (GAD): MARCH9
Human Genome Epidemiology (HuGE) Navigator: MARCH9 (3 documents)

Export disorders for MARCH9 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MARCH9 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MARCH9)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PubMed id 14722266)1, 2, 3, 9 Bartee E.... Frueh K. (J. Virol. 2004)
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  3. MARCH-IX mediates ubiquitination and downregulation of ICAM-1. (PubMed id 17174307)1, 2 Hoer S.... Lehner P.J. (FEBS Lett. 2007)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  6. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
  7. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
  8. Stress-regulated targeting of the NKG2D ligand Mult1 by a membrane-associated RING-CH family E3 ligase. (PubMed id 20870941)1 Nice T.J....Raulet D.H. (J. Immunol. 2010)
  9. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
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  Query String
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OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 92979 HGNC: 25139 AceView: MARCH-IX Ensembl:ENSG00000139266 euGenes: HUgn92979
ECgene: MARCH9 H-InvDB: MARCH9

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MARCH9 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MARCH9 gene:
Search GeneIP for patents involving MARCH9

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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