Aliases for MARCH8 Gene
External Ids for MARCH8 Gene
Previous HGNC Symbols for MARCH8 Gene
Previous GeneCards Identifiers for MARCH8 Gene
MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 188.8.131.52). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]
GeneCards Summary for MARCH8 Gene
MARCH8 (Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. GO annotations related to this gene include ligase activity and MHC class II protein binding. An important paralog of this gene is MARCH2.
UniProtKB/Swiss-Prot for MARCH8 Gene
E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.