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Aliases for MARCH8 Gene

Aliases for MARCH8 Gene

  • Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase 2 3
  • C-Mir, Cellular Modulator Of Immune Recognition 2 3
  • Membrane-Associated RING Finger Protein 8 3 4
  • Membrane-Associated RING-CH Protein VIII 3 4
  • RING Finger Protein 178 3 4
  • MARCH-VIII 3 4
  • RNF178 3 4
  • C-MIR 3 4
  • MIR 3 4
  • Cellular Modulator Of Immune Recognition (C-MIR) 3
  • Membrane-Associated Ring Finger (C3HC4) 8 2
  • Cellular Modulator Of Immune Recognition 4
  • E3 Ubiquitin-Protein Ligase MARCH8 3
  • EC 6.3.2.- 4
  • EC 6.3.2 63
  • CMIR 3

External Ids for MARCH8 Gene

Previous HGNC Symbols for MARCH8 Gene

  • MIR

Previous GeneCards Identifiers for MARCH8 Gene

  • GC10M045273
  • GC10M045950
  • GC10M042478

Summaries for MARCH8 Gene

Entrez Gene Summary for MARCH8 Gene

  • MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]

GeneCards Summary for MARCH8 Gene

MARCH8 (Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity and MHC class II protein binding. An important paralog of this gene is MARCH2.

UniProtKB/Swiss-Prot for MARCH8 Gene

  • E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH8 Gene

Genomics for MARCH8 Gene

Regulatory Elements for MARCH8 Gene

Genomic Location for MARCH8 Gene

Start:
45,454,585 bp from pter
End:
45,594,906 bp from pter
Size:
140,322 bases
Orientation:
Minus strand

Genomic View for MARCH8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARCH8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH8 Gene

Proteins for MARCH8 Gene

  • Protein details for MARCH8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T0T0-MARH8_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MARCH8
    Protein Accession:
    Q5T0T0
    Secondary Accessions:
    • B2R8E7
    • H0Y7C6
    • Q5T0S8
    • Q8TC72

    Protein attributes for MARCH8 Gene

    Size:
    291 amino acids
    Molecular mass:
    32965 Da
    Quaternary structure:
    • Interacts with CD86.

    Three dimensional structures from OCA and Proteopedia for MARCH8 Gene

    Alternative splice isoforms for MARCH8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARCH8 Gene

Proteomics data for MARCH8 Gene at MOPED

Selected DME Specific Peptides for MARCH8 Gene

Post-translational modifications for MARCH8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MARCH8 Gene

Domains for MARCH8 Gene

Gene Families for MARCH8 Gene

HGNC:
  • MARCH :MARCH membrane-associated ring fingers
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for MARCH8 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5T0T0

UniProtKB/Swiss-Prot:

MARH8_HUMAN :
  • Q5T0T0
Domain:
  • The RING-CH-type zinc finger domain is required for E3 ligase activity
Similarity:
  • Contains 1 RING-CH-type zinc finger.
genes like me logo Genes that share domains with MARCH8: view

No data available for Suggested Antigen Peptide Sequences for MARCH8 Gene

Function for MARCH8 Gene

Molecular function for MARCH8 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.

Enzyme Numbers (IUBMB) for MARCH8 Gene

Gene Ontology (GO) - Molecular Function for MARCH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 14722266
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0042289 MHC class II protein binding IEA --
genes like me logo Genes that share ontologies with MARCH8: view

miRNA for MARCH8 Gene

miRTarBase miRNAs that target MARCH8

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MARCH8 Gene

Localization for MARCH8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCH8 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MARCH8 Gene COMPARTMENTS Subcellular localization image for MARCH8 gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
cytosol 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MARCH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 14722266
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome IDA 14722266
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with MARCH8: view

Pathways for MARCH8 Gene

SuperPathways for MARCH8 Gene

No Data Available

UniProtKB/Swiss-Prot Q5T0T0-MARH8_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for MARCH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 19117940
GO:0002376 immune system process --
GO:0002495 antigen processing and presentation of peptide antigen via MHC class II IEA --
GO:0045347 negative regulation of MHC class II biosynthetic process IEA --
genes like me logo Genes that share ontologies with MARCH8: view

No data available for Pathways by source for MARCH8 Gene

Compounds for MARCH8 Gene

(4) HMDB Compounds for MARCH8 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with MARCH8: view

Transcripts for MARCH8 Gene

Unigene Clusters for MARCH8 Gene

Membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
SP1: - - - - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5:
SP6: - -
SP7:

Relevant External Links for MARCH8 Gene

GeneLoc Exon Structure for
MARCH8
ECgene alternative splicing isoforms for
MARCH8

Expression for MARCH8 Gene

mRNA expression in normal human tissues for MARCH8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MARCH8 Gene

This gene is overexpressed in Whole Blood (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MARCH8 Gene

SOURCE GeneReport for Unigene cluster for MARCH8 Gene Hs.499489

mRNA Expression by UniProt/SwissProt for MARCH8 Gene

Q5T0T0-MARH8_HUMAN
Tissue specificity: Broadly expressed. Present in immature dendritic cells (at protein level).
genes like me logo Genes that share expressions with MARCH8: view

Orthologs for MARCH8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MARCH8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARCH8 35
  • 99.07 (n)
  • 97.91 (a)
MARCH8 36
  • 46 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MARCH8 35
  • 90.1 (n)
  • 89.44 (a)
MARCH8 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MARCH8 35
  • 87.46 (n)
  • 83.83 (a)
MARCH8 36
  • 45 (a)
OneToOne
mouse
(Mus musculus)
Mammalia March8 35
  • 88.35 (n)
  • 91 (a)
March8 16
March8 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MARCH8 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MARCH8 36
  • 33 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia March8 35
  • 88 (n)
  • 91 (a)
chicken
(Gallus gallus)
Aves MARCH8 35
  • 76.38 (n)
  • 76.68 (a)
MARCH8 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MARCH8 36
  • 41 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8458 35
tropical clawed frog
(Silurana tropicalis)
Amphibia march8 35
  • 74.11 (n)
  • 84.55 (a)
Str.8463 35
zebrafish
(Danio rerio)
Actinopterygii march8 35
  • 74.6 (n)
  • 82.38 (a)
march8 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4080 36
  • 17 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSM4 36
  • 4 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for MARCH8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARCH8 Gene

ENSEMBL:
Gene Tree for MARCH8 (if available)
TreeFam:
Gene Tree for MARCH8 (if available)

Paralogs for MARCH8 Gene

Paralogs for MARCH8 Gene

Selected SIMAP similar genes for MARCH8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MARCH8: view

Variants for MARCH8 Gene

Sequence variations from dbSNP and Humsavar for MARCH8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs768673 -- 45,471,301(-) TCTGT(C/T)CCCTC intron-variant
rs901682 -- 45,470,413(+) ACTTG(C/T)GGTAT intron-variant
rs901683 -- 45,470,974(+) CTGTG(A/G)CTTTT intron-variant
rs901684 -- 45,471,180(+) CTTAC(A/G)CCAAG intron-variant
rs963029 -- 45,467,939(+) AGACT(C/T)TCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH8 Gene

Variant ID Type Subtype PubMed ID
nsv895107 CNV Loss 21882294
dgv651n71 CNV Gain 21882294
nsv895110 CNV Loss 21882294
nsv895111 CNV Loss 21882294
nsv895112 CNV Gain 21882294
nsv6532 CNV Insertion 18451855
dgv250e1 CNV Complex 17122850
dgv251e1 CNV Complex 17122850
dgv252e1 CNV Complex 17122850
nsv528750 CNV Loss 19592680
dgv253e1 CNV Complex 17122850
esv2750898 CNV Loss 17911159
dgv254e1 CNV Complex 17122850
esv2736141 CNV Deletion 23290073
nsv442178 CNV CNV 18776908

Relevant External Links for MARCH8 Gene

HapMap Linkage Disequilibrium report
MARCH8
Human Gene Mutation Database (HGMD)
MARCH8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH8 Gene

Disorders for MARCH8 Gene

Relevant External Links for MARCH8

Genetic Association Database (GAD)
MARCH8
Human Genome Epidemiology (HuGE) Navigator
MARCH8
genes like me logo Genes that share disorders with MARCH8: view

No data available for UniProtKB/Swiss-Prot for MARCH8 Gene

Publications for MARCH8 Gene

  1. c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity. (PMID: 12582153) Goto E. … Hotta H. (J. Biol. Chem. 2003) 2 3 4 23
  2. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E. … Frueh K. (J. Virol. 2004) 2 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48

Products for MARCH8 Gene

Sources for MARCH8 Gene

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