MARCH8 Gene
protein-coding GIFtS: 48
GCID: GC10M045950
|
|
membrane-associated ring finger (C3HC4) 8, E3 ubiquitin...(Previous names: c-mir, cellular modulator of immune recognition, membrane-associated...)
(Previous symbol: MIR)
| |
Aliases
for MARCH8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase1 2 | | RING Finger Protein 1782 3 | | MARCH-VIII1 2 3 | | Membrane-Associated Ring Finger (C3HC4) 81 | | MIR1 2 3 | | Cellular Modulator Of Immune Recognition (C-MIR)2 | | RNF1781 2 3 | | E3 Ubiquitin-Protein Ligase MARCH82 | | C-MIR1 | | EC 6.3.2.-3 | | C-Mir, Cellular Modulator Of Immune Recognition1 2 | | Cellular Modulator Of Immune Recognition3 | | Membrane-Associated RING Finger Protein 82 3 | | EC 6.3.28 | | Membrane-Associated RING-CH Protein VIII2 3 | | |
Export aliases for MARCH8 gene to outside databasesPrevious GC identifers: GC10M045273 GC10M042478 |
Summaries
for MARCH8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MARCH8:
MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes addubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transportbetween membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003(PubMed 12582153); Bartee et al., 2004 (PubMed 14722266)).(supplied by OMIM, Apr 2010)
UniProtKB/Swiss-Prot: MARH8_HUMAN, Q5T0T0Function: E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DRalpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May alsopromote ubiquitination and endocytosis of TFRC and FAS
|
Genomic Views
for MARCH8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_033985.7
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MARCH8 gene promoter:
AML1a HTF NF-YA N-Myc NF-YB CBF-A CBF-B CP1A NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for MARCH8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARCH8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11.21 Ensembl cytogenetic band: 10q11.21 HGNC cytogenetic band: 10q11.22MARCH8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M045950: view genomic region
(about GC identifiers)
Start:
|
45,950,035 bp from pter |
End:
|
46,090,354 bp from pter |
Size:
|
140,320 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr10-,PATCHES 45,960,848-45,967,902 |
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Proteins
for MARCH8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MARH8_HUMAN, Q5T0T0 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase MARCH8 Size: 291 amino acids; 32965 Da
Subunit: Interacts with CD86
Subcellular location: Cytoplasmic vesicle membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membraneprotein. Early endosome membrane; Multi-pass membrane protein
1 PDB 3D structure from  and Proteopedia  for MARCH8:2D8S (3D)
Secondary accessions: B2R8E7 Q5T0S8 Q8TC72Explore the universe of human proteins at neXtProt for MARCH8: NX_Q5T0T0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T0T0
4/5 DME Specific Peptides for MARCH8 (Q5T0T0) (see all 5)
MARCH8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001002265.1 NP_001002266.1 NP_659458.2
ENSEMBL proteins: ENSP00000411848 ENSP00000379116 ENSP00000396678 ENSP00000379118 ENSP00000317087
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
MARCH8 for ontologies About GeneDecksing
MARCH8 Antibody Products:
Assay Products for MARCH8: |
Protein
Domains /
Families
for MARCH8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MARCH8 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5T0T0ProtoNet protein and cluster: Q5T0T0 1 Blocks protein family: IPB011016 RINGv
UniProtKB/Swiss-Prot: MARH8_HUMAN, Q5T0T0Domain: The RING-CH-type zinc finger domain is required for E3 ligase activitySimilarity: Contains 1 RING-CH-type zinc finger |
Function
for MARCH8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MARH8_HUMAN, Q5T0T0Function: E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DRalpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May alsopromote ubiquitination and endocytosis of TFRC and FASEnzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MARCH8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MARCH8 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for MARCH8 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MARCH8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH8 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
MARCH8 for ontologies About GeneDecksing
|
Pathways & Interactions
for MARCH8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: MARH8_HUMAN, Q5T0T0Pathway: Protein modification; protein ubiquitinationInteractions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MARCH8
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for MARCH8 (Q5T0T03 ENSP000003170874) via UniProtKB, MINT, STRING, and/or I2D About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000209 | protein polyubiquitination |
IDA | 19117940 | | GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II |
IEA | -- | | GO:0045347 | negative regulation of MHC class II biosynthetic process |
IEA | -- |
MARCH8 for ontologies About GeneDecksing
|
Drugs & Compounds
for MARCH8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MARCH8
4 HMDB Compounds for MARCH8 About this table
Search CenterWatch for drugs/clinical trials and news about MARCH8 / MARH8
|
Transcripts
for MARCH8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MARCH8 gene (3 alternative transcripts): NM_001002265.1 NM_001002266.1 NM_145021.4 Unigene Cluster for MARCH8: Membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase Hs.499489 [show with all ESTs]Unigene Representative Sequence: AL8333166 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000453424(uc001jch.2) ENST00000395769(uc001jci.1) ENST00000476962(uc001jcg.1)
ENST00000453980 ENST00000395771(uc001jcj.1) ENST00000319836(uc001jck.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MARCH8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MARCH8 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for MARCH8 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MARCH8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH8 |
Additional cDNA sequence: AK025472.1 AK057289.1 AK125414.1 AK307667.1 AK313340.1 AL833316.1 BC025394.2 BC066988.1 15 DOTS entries: DT.219315 DT.100784031 DT.97845013 DT.91662938 DT.100784026 DT.121243001 DT.75174163 DT.100784024 DT.100784030 DT.121243040 DT.121243042 DT.453193 DT.97777746 DT.97845012 DT.100865517 24/181 AceView cDNA sequences (see all 181): BI520441 BE247000 AA770170 BU789420 AA877903 AK023636 BX471695 CK820047 BM673414 BM769934 AA417027 AI815040 AI127690 BG433948 BM823634 BM773473 AL833316 CA774876 BU069564 AA045509 AK057289 BM707290 AI453731 CA427894
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MARCH8 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | · | 12c |
|---|
|
| SP1: | | | - | | - | | - | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MARCH8
|
Expression
for MARCH8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MARCH8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGGTGTAG
About this image
See MARCH8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MARCH8
SOURCE GeneReport for Unigene cluster: Hs.499489
UniProtKB/Swiss-Prot: MARH8_HUMAN, Q5T0T0Tissue specificity: Broadly expressed. Present in immature dendritic cells (at protein level)
SABiosciences Expression via Pathway-Focused PCR Array including MARCH8: | Ubiquitin Ligases in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MARCH8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MARCH8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARCH8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARCH8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH8 |
Orthologs
for MARCH8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MARCH8 gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MARCH81 |
membrane-associated ring finger (C3HC4) 8 |
81.7(n)
88.11(a) |
|
423770 XM_421642.3 XP_421642.1 |
lizard
(Anolis carolinensis) |
Reptilia |
MARCH86 |
-- |
72(a) |
1 ↔ 1 |
4(74298052-74310381) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.84582 |
Xenopus laevis transcribed sequence with moderate similarity more |
79.24(n) |
|
CA986927.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
march81 |
membrane-associated ring finger (C3HC4) 8 |
73.64(n)
80.5(a) |
|
567818 NM_001161435.1 NP_001154907.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG40806 |
-- |
16(a) |
1 → many |
3L(9379927-9392327) |
ENSEMBL Gene Tree for MARCH8 (if available)
TreeFam Gene Tree for MARCH8 (if available) |
Paralogs
for MARCH8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MARCH8 gene
- MARCH32 MARCH112 MARCH12 MARCH42 MARCH22 MARCH92
2 SIMAP similar genes for MARCH8 using alignment to 2 protein entries: MARH8_HUMAN (see all proteins):MARCH1 MARCH3
MARCH8 for paralogs About GeneDecksing
|
Genomic Variants
for MARCH8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MARCH8 (45950035 - 46090354 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for MARCH8
5 CNVs: 9150 2863 34456 38196 3798 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MARCH8 |
|
Disorders
/ Diseases
for MARCH8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MARCH8 for disorders About MalaCards
MARCH8 for disorders About GeneDecksing
OMIM gene information: 613335
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MARCH8 (2 documents)
Export disorders for MARCH8 gene to outside databases
|
Publications
for MARCH8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MARCH8 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with MARCH8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity. (PubMed id 12582153)1, 2, 3, 9 Goto E.... Hotta H. (2003)
- Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PubMed id 14722266)1, 2, 3 Bartee E.... Frueh K. (2004)
- The HLA-DRalpha chain is modified by polyubiquitination. (PubMed id 19117940)1, 2 Lapaque N....Kelly A.P. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes. (PubMed id 18389477)2, 9 Thibodeau J....Steimle V. (2008)
- The E3 ubiquitin ligase MARCH8 negatively regulates IL -1b-induced NF-kB activation by targeting the IL1RAP coreceptor for ubiquitinati on and degradation. (PubMed id 22904187)1 Chen R....Shu H.B. (2012)
- MARCH ubiquitin ligases alter the itinerary of clathr in-independent cargo from recycling to degradation. (PubMed id 21757542)1 Eyster C.A....Donaldson J.G. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
|
External Searches for MARCH8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MARCH8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MARCH8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MARCH8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MARCH8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MARCH8 gene:
Search GeneIP for patents involving MARCH8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MARCH8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for MARCH8 | | OriGene shRNA RFP for MARCH8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MARCH8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MARCH8 | | | OriGene Protein Over-expression Lysate for MARCH8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MARCH8 | | OriGene 3'-UTR Clone for MARCH8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MARCH8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MARCH8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MARCH8 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MARCH8 | | OriGene Custom Protein Services for MARCH8 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MARCH8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MARCH8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARCH8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARCH8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARCH8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARCH8 |
| |
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| |  |  |  |  | | | | |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH8 |
|  |  |  | | | | ThermoFisher Antibody for MARCH8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH8 |
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