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MARCH8 Gene

protein-coding   GIFtS: 51
GCID: GC10M045950

Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin...

(Previous names: c-mir, cellular modulator of immune recognition, membrane-associated...)
(Previous symbol: MIR)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein
Ligase1 2
     RING Finger Protein 1782 3
MIR1 2 3     Membrane-Associated Ring Finger (C3HC4) 81
C-Mir, Cellular Modulator Of Immune Recognition1 2     Cellular Modulator Of Immune Recognition (C-MIR)2
Membrane-Associated RING Finger Protein 82 3     E3 Ubiquitin-Protein Ligase MARCH82
Membrane-Associated RING-CH Protein VIII2 3     EC 6.3.2.-3
MARCH-VIII2 3     Cellular Modulator Of Immune Recognition3
RNF1782 3     EC 6.3.28
c-MIR2 3     

External Ids:    HGNC: 233561   Entrez Gene: 2209722   Ensembl: ENSG000001654067   OMIM: 6133355   UniProtKB: Q5T0T03   

Export aliases for MARCH8 gene to outside databases

Previous GC identifers: GC10M045273 GC10M042478


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MARCH8 Gene:
MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add
ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport
between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al.,
2003 (PubMed 12582153); Bartee et al., 2004 (PubMed 14722266)).(supplied by OMIM, Apr 2010)

GeneCards Summary for MARCH8 Gene:
MARCH8 (membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity and MHC class II protein binding. An important paralog of this gene is MARCH6.

UniProtKB/Swiss-Prot: MARH8_HUMAN, Q5T0T0
Function: E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as
HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular
bodies. May also promote ubiquitination and endocytosis of TFRC and FAS




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MARCH8 gene promoter:
         AML1a   HTF   NF-YA   N-Myc   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MARCH8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARCH8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.21   Ensembl cytogenetic band:  10q11.21   HGNC cytogenetic band: 10q11.22

MARCH8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCH8 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M045950:  view genomic region     (about GC identifiers)

Start:
45,950,035 bp from pter      End:
46,090,354 bp from pter
Size:
140,320 bases      Orientation:
minus strand

1 alternative location:
Chr10-,NW_003315935 298,200-305,254     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MARH8_HUMAN, Q5T0T0 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MARCH8  
Size: 291 amino acids; 32965 Da
Subunit: Interacts with CD86
1 PDB 3D structure from and Proteopedia for MARCH8:
2D8S (3D)    
Secondary accessions: B2R8E7 Q5T0S8 Q8TC72

Explore the universe of human proteins at neXtProt for MARCH8: NX_Q5T0T0

Explore proteomics data for MARCH8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MARCH8 (Q5T0T0) (see all 5)
     RLKAYNRVI  CTGSLHFVHQ  QDICRICHCEGD  FIMETKLKPLRKWEKLQMT 


    See MARCH8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001002266.1  NP_001269795.1  NP_659458.2  

    ENSEMBL proteins: 
     ENSP00000411848   ENSP00000379116   ENSP00000396678   ENSP00000379118   ENSP00000317087  

    MARCH8 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for MARCH8
    OriGene Protein Over-expression Lysate for MARCH8
    OriGene MassSpec for MARCH8
    OriGene Custom Protein Services for MARCH8
    GenScript Custom Purified and Recombinant Proteins Services for MARCH8
    Novus Biologicals MARCH8 Proteins
    Novus Biologicals MARCH8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MARCH8 

     
    antibodies-online proteins for MARCH8 (4 products) 

     
    antibodies-online peptides for MARCH8

    MARCH8 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MARCH8 (8-Mar)
    OriGene Antibodies for MARCH8
    OriGene Custom Antibody Services for MARCH8
    Novus Biologicals MARCH8 Antibodies
    Search for Antibodies for MARCH8 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for MARCH8
    Search LSBio for Antibodies for MARCH8
    antibodies-online antibodies for MARCH8 (41 products) 

    MARCH8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MARCH8
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MARCH8
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for MARCH8 
    antibodies-online kits for MARCH8 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers
    MARCH: MARCH membrane-associated ring fingers

    2 InterPro protein domains:
     IPR013083 Znf_RING/FYVE/PHD
     IPR011016 Znf_RING-CH

    Graphical View of Domain Structure for InterPro Entry Q5T0T0

    ProtoNet protein and cluster: Q5T0T0

    1 Blocks protein domain: IPB011016 RINGv

    UniProtKB/Swiss-Prot: MARH8_HUMAN, Q5T0T0
    Domain: The RING-CH-type zinc finger domain is required for E3 ligase activity
    Similarity: Contains 1 RING-CH-type zinc finger


    Find genes that share domains with MARCH8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARH8_HUMAN, Q5T0T0
    Function: E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as
    HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular
    bodies. May also promote ubiquitination and endocytosis of TFRC and FAS

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA14722266
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0042289MHC class II protein binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with MARCH8           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MARCH8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MARCH8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARCH8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARCH8

    miRNA
    Products:
        
    miRTarBase miRNAs that target MARCH8:
    hsa-mir-335-5p (MIRT017780)

    Block miRNA regulation of human, mouse, rat MARCH8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MARCH8 (see all 40):
    hsa-miR-302d hsa-miR-520e hsa-miR-3146 hsa-miR-106a hsa-miR-30d hsa-miR-449a hsa-miR-548m hsa-miR-124
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MARCH8
    Predesigned siRNA for gene silencing in human, mouse, rat MARCH8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MARCH8

    Clone
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    OriGene clones in human, mouse for MARCH8 (see all 16)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MARCH8
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH8

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MARCH8
    Browse ESI BIO Cell Lines and PureStem Progenitors for MARCH8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MARH8_HUMAN, Q5T0T0: Cytoplasmic vesicle membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass
    membrane protein. Early endosome membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    lysosome5
    vacuole5
    cytosol3
    plasma membrane3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome IDA14722266
    GO:0005765lysosomal membrane IEA--
    GO:0005768endosome IDA14722266
    GO:0016021integral component of membrane IEA--
    GO:0030659cytoplasmic vesicle membrane IEA--

    Find genes that share ontologies with MARCH8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: MARH8_HUMAN, Q5T0T0
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including MARCH8: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MARCH8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MARCH8 (Q5T0T03 ENSP000003170874) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD86P420813, ENSP000003320494I2D: score=1 STRING: ENSP00000332049
    NPLOC4ENSP000003314874STRING: ENSP00000331487
    UBE2G2ENSP000003383484STRING: ENSP00000338348
    AMFRENSP000002906494STRING: ENSP00000290649
    CSTF3ENSP000003157914STRING: ENSP00000315791
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA19117940
    GO:0002495antigen processing and presentation of peptide antigen via MHC class II IEA--
    GO:0016567protein ubiquitination ----
    GO:0045347negative regulation of MHC class II biosynthetic process IEA--

    Find genes that share ontologies with MARCH8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MARCH8 (MARH8)

    4 HMDB Compounds for MARCH8    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MARCH8 gene (4 alternative transcripts): 
    NM_001002265.1  NM_001002266.2  NM_001282866.1  NM_145021.5  

    Unigene Cluster for MARCH8:

    Membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
    Hs.499489  [show with all ESTs]
    Unigene Representative Sequence: AL833316
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000453424(uc001jch.2) ENST00000395769(uc001jci.1) ENST00000476962(uc001jcg.1)
    ENST00000602712 ENST00000453980 ENST00000451376 ENST00000395771(uc001jcj.1)
    ENST00000319836(uc001jck.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MARCH8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MARCH8 (see all 40):
    hsa-miR-302d hsa-miR-520e hsa-miR-3146 hsa-miR-106a hsa-miR-30d hsa-miR-449a hsa-miR-548m hsa-miR-124
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MARCH8
    Predesigned siRNA for gene silencing in human, mouse, rat MARCH8
    Clone
    Products:
         
    OriGene clones in human, mouse for MARCH8 (see all 16)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MARCH8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH8
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MARCH8
    OriGene qSTAR qPCR primer pairs in human, mouse for MARCH8
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MARCH8
      QuantiTect SYBR Green Assays in human, mouse, rat MARCH8
      QuantiFast Probe-based Assays in human, mouse, rat MARCH8

    Additional mRNA sequence: 

    AK025472.1 AK057289.1 AK125414.1 AK307667.1 AK313340.1 AL833316.1 BC025394.2 BC066988.1 

    15 DOTS entries:

    DT.219315  DT.100784031  DT.97845013  DT.91662938  DT.100784026  DT.121243001  DT.75174163  DT.100784024 
    DT.100784030  DT.121243040  DT.121243042  DT.453193  DT.97777746  DT.97845012  DT.100865517 

    Selected AceView cDNA sequences (see all 181):

    BU069564 BM773473 AI815040 NM_001002266 BX471695 BU789160 AA045509 AK023636 
    H85582 AJ705458 AI127690 BE247000 CA774876 AA877903 BM823634 BU069357 
    AL558994 BM673414 CB268758 NM_001002265 CA775148 AI829996 AA609297 AA887901 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MARCH8 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
    SP1:        -     -     -                             -     -     -     -                                 
    SP2:                                                  -     -     -     -                                 
    SP3:                                                                    -     -                           
    SP4:                                                                    -                                 
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for MARCH8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MARCH8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGGTGTAG
    MARCH8 Expression
    About this image


    MARCH8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Testis (Reproductive System)
    MARCH8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MARCH8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.499489

    UniProtKB/Swiss-Prot: MARH8_HUMAN, Q5T0T0
    Tissue specificity: Broadly expressed. Present in immature dendritic cells (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Array including MARCH8: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MARCH8
    OriGene qSTAR qPCR primer pairs in human, mouse for MARCH8
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MARCH8
    QuantiTect SYBR Green Assays in human, mouse, rat MARCH8
    QuantiFast Probe-based Assays in human, mouse, rat MARCH8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MARCH8 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia March81 , 5 membrane-associated ring finger (C3HC4) 81, 5 88.35(n)1
    91(a)1
      6 (53.78 cM)5
    717791  NM_027920.41  NP_082196.11 
     1163380245 
    chicken
    (Gallus gallus)
    Aves MARCH81 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin more 76.38(n)
    76.68(a)
      423770  XM_004942116.1  XP_004942173.1 
    lizard
    (Anolis carolinensis)
    Reptilia MARCH86
    membrane-associated ring finger (C3HC4) 8, E3 ubiq...
    41(a)
    1 ↔ 1
    4(74298052-74310381)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.84582 Xenopus laevis transcribed sequence with moderate similarity more 79.24(n)    CA986927.1 
    zebrafish
    (Danio rerio)
    Actinopterygii march81 membrane-associated ring finger (C3HC4) 8 74.6(n)
    82.38(a)
      567818  NM_001161435.1  NP_001154907.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG40806
    --
    17(a)
    1 → many
    3L(9379927-9392327)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSM46
    Ubiquitin-protein ligase involved in ER-associated...
    4(a)
    1 → many
    IX(296050-300009) YIL030C


    ENSEMBL Gene Tree for MARCH8 (if available)
    TreeFam Gene Tree for MARCH8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MARCH8 gene
    MARCH62  MARCH32  MARCH12  MARCH22  
    2 SIMAP similar genes for MARCH8 using alignment to 2 protein entries:     MARH8_HUMAN (see all proteins):
    MARCH1    MARCH3

    Find genes that share paralogs with MARCH8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MARCH8 (see all 2645)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830090231,2
    --45952372(+) TCCTGC/TCTGTT 3 -- ds50010--------
    rs38246181,2
    C,F,H--45952433(-) GGTCCG/ACTGTG 3 -- ds5001 ese36Minor allele frequency- A:0.05NS EA NA 658
    rs114238361,2
    C--45952669(+) GAATA-/TTTTTT 3 -- ds50010--------
    rs1433853471,2
    --45952705(+) ACTCAC/TTTCCT 3 -- ds50010--------
    rs38025481,2
    C,F,A--45952745(-) CACTGA/TAAAAG 3 -- ds500113Minor allele frequency- T:0.18NA NS EA CSA WA 926
    rs38025471,2
    C,F,H--45952746(-) ACACTG/AAAAAA 3 -- ds5001 ese39Minor allele frequency- A:0.04NS EA 1144
    rs38025461,2
    C,F,H--45952785(-) TTACTT/GTGTAG 3 -- ds50014Minor allele frequency- G:0.01NS EA 420
    rs1857863291,2
    C--45952807(+) AAAACA/TGGCTC 3 -- ds50010--------
    rs776775211,2
    C,F--45952896(+) CTGGCC/GTGCTT 3 -- ut311Minor allele frequency- G:0.03NA 120
    rs38246161,2
    C,F,H--45952929(+) TCTGTT/CTTATG 3 -- ut3127Minor allele frequency- C:0.10EA NA NS WA CSA 4450

    HapMap Linkage Disequilibrium report for MARCH8 (45950035 - 46090354 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MARCH8 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736141CNV Deletion23290073
    nsv6532CNV Insertion18451855
    nsv895107CNV Loss21882294
    nsv895111CNV Loss21882294
    esv2750898CNV Loss17911159
    nsv895110CNV Loss21882294
    nsv528750CNV Loss19592680
    dgv651n71CNV Gain21882294
    nsv895112CNV Gain21882294
    nsv442178CNV CNV18776908

    Human Gene Mutation Database (HGMD): MARCH8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MARCH8
    DNA2.0 Custom Variant and Variant Library Synthesis for MARCH8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613335    OMIM disorders: --


    Find genes that share disorders with MARCH8           About GenesLikeMe

    Genetic Association Database (GAD): MARCH8
    Human Genome Epidemiology (HuGE) Navigator: MARCH8 (2 documents)

    Export disorders for MARCH8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MARCH8 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with MARCH8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity. (PubMed id 12582153)1, 2, 3, 9 Goto E.... Hotta H. (J. Biol. Chem. 2003)
    2. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PubMed id 14722266)1, 2, 3 Bartee E.... Frueh K. (J. Virol. 2004)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PubMed id 20139978)1, 4 Kamatani Y....Kamatani N. (Nat. Genet. 2010)
    5. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PubMed id 19862010)1, 4 Ganesh S.K....Lin J.P. (Nat. Genet. 2009)
    6. The HLA-DRalpha chain is modified by polyubiquitination. (PubMed id 19117940)1, 2 Lapaque N.... Kelly A.P. (J. Biol. Chem. 2009)
    7. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 220972 HGNC: 23356 AceView: MIR Ensembl:ENSG00000165406 euGenes: HUgn220972
    ECgene: MARCH8 H-InvDB: MARCH8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MARCH8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MARCH8 gene:
    Search GeneIP for patents involving MARCH8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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