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MARCH7 Gene

protein-coding   GIFtS: 51
GCID: GC02P160569

Membrane-Associated Ring Finger (C3HC4) 7, E3 Ubiquitin...

(Previous names: axotrophin, membrane-associated ring finger (C3HC4) 7)
(Previous symbol: AXOT)
  Search for MARCH7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Membrane-Associated Ring Finger (C3HC4) 7, E3 Ubiquitin Protein
Ligase1 2
     RING Finger Protein 1772 3
AXOT1 2 3     Membrane-Associated Ring Finger (C3HC4) 71
axotrophin1 2     AXO2
Membrane-Associated RING Finger Protein 72 3     E3 Ubiquitin-Protein Ligase MARCH72
Membrane-Associated RING-CH Protein VII2 3     Axotrophin3
MARCH-VII2 3     EC 6.3.2.-3
RNF1772 3     EC 6.3.28

External Ids:    HGNC: 173931   Entrez Gene: 648442   Ensembl: ENSG000001365367   OMIM: 6133345   UniProtKB: Q9H9923   

Export aliases for MARCH7 gene to outside databases

Previous GC identifers: GC02P160395 GC02P160277 GC02P152452


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MARCH7 Gene:
MARCH7 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add
ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport
between membrane compartments (Bartee et al., 2004 (PubMed 14722266)).(supplied by OMIM, Mar 2010)

GeneCards Summary for MARCH7 Gene:
MARCH7 (membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase) is a protein-coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is MARCH10.

UniProtKB/Swiss-Prot: MARH7_HUMAN, Q9H992
Function: E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases
accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer
the ubiquitin to targeted substrates

Gene Wiki entry for MARCH7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MARCH7 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU2F2   POU2F2C   POU2F1   FOXJ2 (long isoform)   POU2F1a   POU2F2B   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MARCH7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARCH7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.2   Ensembl cytogenetic band:  2q24.2   HGNC cytogenetic band: 2q24.2

MARCH7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCH7 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P160569:  view genomic region     (about GC identifiers)

Start:
160,569,000 bp from pter      End:
160,627,538 bp from pter
Size:
58,539 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MARH7_HUMAN, Q9H992 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MARCH7  
Size: 704 amino acids; 78051 Da
Secondary accessions: A8K9X1 D3DPB0 Q53GQ1 Q9BTR9

Explore the universe of human proteins at neXtProt for MARCH7: NX_Q9H992

Explore proteomics data for MARCH7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys536, Lys571, Lys608
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MARCH7 (Q9H992) (see all 7)
     PCKCTGS  SSTNHQLPS  ITVDIIPSGW  EEEGDLCRICQ 


    See MARCH7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001269734.1  NP_001269735.1  NP_001269736.1  NP_073737.1  

    ENSEMBL proteins: 
     ENSP00000386830   ENSP00000259050   ENSP00000392862   ENSP00000387238   ENSP00000391493  
     ENSP00000442992  

    MARCH7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MARCH7
    GenScript Custom Purified and Recombinant Proteins Services for MARCH7
    Novus Biologicals MARCH7 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MARCH7 

    MARCH7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MARCH7
    OriGene Custom Antibody Services for MARCH7
    Novus Biologicals MARCH7 Antibodies
    Search for Antibodies for MARCH7 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for MARCH7
    Search LSBio for Antibodies for MARCH7

    MARCH7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MARCH7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MARCH7
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for MARCH7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers
    MARCH: MARCH membrane-associated ring fingers

    2 InterPro protein domains:
     IPR013083 Znf_RING/FYVE/PHD
     IPR011016 Znf_RING-CH

    Graphical View of Domain Structure for InterPro Entry Q9H992

    ProtoNet protein and cluster: Q9H992

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: MARH7_HUMAN, Q9H992
    Domain: The RING-CH-type zinc finger domain is required for E3 ligase activity
    Similarity: Contains 1 RING-CH-type zinc finger


    Find genes that share domains with MARCH7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARH7_HUMAN, Q9H992
    Function: E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases
    accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer
    the ubiquitin to targeted substrates

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with MARCH7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MARCH7:
     Increased cell number in G1, a 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for March7):
     hematopoietic system  homeostasis/metabolism  immune system  nervous system 

    Find genes that share phenotypes with MARCH7           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MARCH7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MARCH7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARCH7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARCH7

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MARCH7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MARCH7 (see all 23):
    hsa-miR-549 hsa-miR-3910 hsa-miR-607 hsa-miR-137 hsa-miR-200a hsa-miR-139-5p hsa-miR-141 hsa-miR-144
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MARCH7
    Predesigned siRNA for gene silencing in human, mouse, rat MARCH7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MARCH7

    Clone
    Products:
         
    OriGene clones in human, mouse for MARCH7 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MARCH7
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MARCH7
    Browse ESI BIO Cell Lines and PureStem Progenitors for MARCH7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    plasma membrane4
    endoplasmic reticulum2
    golgi apparatus2
    mitochondrion2
    nucleus2
    extracellular1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: MARH7_HUMAN, Q9H992
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including MARCH7: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MARCH7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MARCH7 (Q9H9922, 3 ENSP000002590504) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP7Q930092, 3, ENSP000003435354MINT-2876080 I2D: score=3 STRING: ENSP00000343535
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    VAV2P527353, ENSP000003609164I2D: score=1 STRING: ENSP00000360916
    UBE2KP610863, ENSP000002614274I2D: score=1 STRING: ENSP00000261427
    RNF111ENSP000002881994STRING: ENSP00000288199
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    Find genes that share ontologies with MARCH7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MARCH7 (MARH7)

    4 HMDB Compounds for MARCH7    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MARCH7 gene (4 alternative transcripts): 
    NM_001282805.1  NM_001282806.1  NM_001282807.1  NM_022826.3  

    Unigene Cluster for MARCH7:

    Membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
    Hs.529272  [show with all ESTs]
    Unigene Representative Sequence: AK124225
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409175 ENST00000259050(uc002uax.3 uc010foq.3 uc010zcn.2 uc010for.3 uc002uay.3)
    ENST00000421037 ENST00000473749 ENST00000409591 ENST00000461582 ENST00000420397
    ENST00000478396 ENST00000539065
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MARCH7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MARCH7 (see all 23):
    hsa-miR-549 hsa-miR-3910 hsa-miR-607 hsa-miR-137 hsa-miR-200a hsa-miR-139-5p hsa-miR-141 hsa-miR-144
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MARCH7
    Predesigned siRNA for gene silencing in human, mouse, rat MARCH7
    Clone
    Products:
         
    OriGene clones in human, mouse for MARCH7 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MARCH7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH7
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MARCH7
    OriGene qSTAR qPCR primer pairs in human, mouse for MARCH7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARCH7
      QuantiTect SYBR Green Assays in human, mouse, rat MARCH7
      QuantiFast Probe-based Assays in human, mouse, rat MARCH7

    Additional mRNA sequence: 

    AF086110.1 AK022973.1 AK023400.1 AK124225.1 AK222880.1 AK292836.1 AK299051.1 AK302347.1 
    AK310238.1 AK316382.1 AL050171.1 AL833651.1 BC003404.1 BC065014.1 CR627026.1 

    21 DOTS entries:

    DT.100818768  DT.416796  DT.417390  DT.100818769  DT.95314071  DT.91995208  DT.445618  DT.95314072 
    DT.120993604  DT.100818767  DT.100818763  DT.100736480  DT.200651  DT.120993701  DT.304006  DT.97775071 
    DT.100690645  DT.100717775  DT.120993595  DT.91837646  DT.95363255 

    Selected AceView cDNA sequences (see all 273):

    AI452649 AI478160 AA046405 AL597638 AI309539 AL833651 CD244630 BM982036 
    BF438895 BP363743 BU172500 CB241397 AL698895 AA767752 AA307375 BM468831 
    AL050171 CN483858 BU849246 BP350271 AW070802 AI742915 AA136390 BP352310 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MARCH7 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13
    SP1:                                                                                                            
    SP2:                                                                                      -                     
    SP3:              -                                                                                             
    SP4:                                                                                                            
    SP5:                                -     -     -                                                               


    ECgene alternative splicing isoforms for MARCH7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MARCH7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATTTCTCA
    MARCH7 Expression
    About this image


    MARCH7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    MARCH7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MARCH7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529272
        Pathway & Disease-focused RT2 Profiler PCR Array including MARCH7: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MARCH7
    OriGene qSTAR qPCR primer pairs in human, mouse for MARCH7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARCH7
    QuantiTect SYBR Green Assays in human, mouse, rat MARCH7
    QuantiFast Probe-based Assays in human, mouse, rat MARCH7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MARCH7 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia March71 , 5 membrane-associated ring finger (C3HC4) 71, 5 87.43(n)1
    86.03(a)1
      2 (34.46 cM)5
    574381  NM_020575.21  NP_065600.11 
     602098875 
    chicken
    (Gallus gallus)
    Aves MARCH71 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin more 72.19(n)
    68.39(a)
      424332  XM_004943062.1  XP_004943119.1 
    lizard
    (Anolis carolinensis)
    Reptilia MARCH76
    membrane-associated ring finger (C3HC4) 7, E3 ubiq...
    60(a)
    1 ↔ 1
    GL343371.1(931502-949354)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU913136.12   -- 78.93(n)    BU913136.1 
    zebrafish
    (Danio rerio)
    Actinopterygii march71 membrane-associated ring finger (C3HC4) 7 51.52(n)
    47.77(a)
      100136862  NM_001114580.2  NP_001108052.2 


    ENSEMBL Gene Tree for MARCH7 (if available)
    TreeFam Gene Tree for MARCH7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MARCH7 gene
    MARCH102  
    2 SIMAP similar genes for MARCH7 using alignment to 5 protein entries:     MARH7_HUMAN (see all proteins):
    MARCH10    MARCH6

    Find genes that share paralogs with MARCH7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MARCH7 (see all 1266)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1474069031,2
    --160567036(+) CAGCAC/TAGCAA 1 -- us2k10--------
    rs1396158971,2
    --160567076(+) AATTAC/TCTGAA 1 -- us2k10--------
    rs1157616481,2
    F--160567099(+) AGAGAG/ATACAT 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1453059091,2
    --160567225(+) ATACTC/TACTTT 1 -- us2k10--------
    rs38213001,2
    C,F,H--160567230(-) ATTATA/GAAGTG 1 -- us2k1 tfbs327Minor allele frequency- G:0.36EA NS NA WA 4266
    rs1147592421,2
    C,F--160567232(+) CTTTAT/CAATAT 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs754173801,2
    --160567377(+) TCTTAC/GCATAA 1 -- us2k10--------
    rs1808998841,2
    C--160567445(+) TATTGA/GTGGTT 1 -- us2k10--------
    rs1396114341,2
    --160567447(+) TTGGTC/GGTTTA 1 -- us2k10--------
    rs19727081,2
    C,F,H--160567510(+) TGACGC/TGTTAT 1 -- us2k1 tfbs331Minor allele frequency- T:0.10NS EA NA WA CSA 2783

    HapMap Linkage Disequilibrium report for MARCH7 (160569000 - 160627538 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MARCH7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2443442CNV Deletion19546169
    nsv470497CNV Loss18288195
    dgv4351n71CNV Loss21882294
    nsv875344CNV Loss21882294
    nsv834436CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MARCH7
    DNA2.0 Custom Variant and Variant Library Synthesis for MARCH7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 613334    OMIM disorders: --


    Find genes that share disorders with MARCH7           About GenesLikeMe

    1 Novoseek inferred disease relationship for MARCH7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 56.1 4 16147533 (2), 17161353 (1), 17632414 (1)


    Export disorders for MARCH7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MARCH7 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with MARCH7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. (PubMed id 16868077)1, 2, 9 Flierman D.... Chau V. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    2. Leukaemia inhibitory factor (LIF) is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance. (PubMed id 15670816)1, 2 Metcalfe S.M....Lyons G.E. (FEBS Lett. 2005)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PubMed id 14722266)1, 3 Bartee E.... Frueh K. (J. Virol. 2004)
    7. Evidence for functional inter-relationships between FOXP3, leukaemia inhibitory factor, and axotrophin/MARCH-7 in transplantation tolerance. (PubMed id 17161353)1, 9 Muthukumarana P.A....Metcalfe S.M. (Int. Immunopharmacol. 2006)
    8. The E3 ligase axotrophin/MARCH-7: protein expression profiling of human tissues reveals links to adult stem cells. (PubMed id 19901269)1, 9 Szigyarto C.A....Metcalfe S.M. (J. Histochem. Cytochem. 2010)
    9. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    10. Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR). (PubMed id 22544753)1 Agrawal P....Hughes R.E. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64844 HGNC: 17393 AceView: AXOT Ensembl:ENSG00000136536 euGenes: HUgn64844
    ECgene: MARCH7 H-InvDB: MARCH7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MARCH7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MARCH7 gene:
    Search GeneIP for patents involving MARCH7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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