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Aliases for MARCH7 Gene

Aliases for MARCH7 Gene

  • Membrane Associated Ring-CH-Type Finger 7 2 3 5
  • Axotrophin 2 3 4
  • Membrane-Associated Ring Finger (C3HC4) 7, E3 Ubiquitin Protein Ligase 2 3
  • Membrane-Associated RING Finger Protein 7 3 4
  • RING-Type E3 Ubiquitin Transferase MARCH7 3 4
  • Membrane-Associated RING-CH Protein VII 3 4
  • RING Finger Protein 177 3 4
  • MARCH-VII 3 4
  • RNF177 3 4
  • AXOT 3 4
  • Membrane-Associated Ring Finger (C3HC4) 7 2
  • E3 Ubiquitin-Protein Ligase MARCH7 3
  • Membrane Associated Ring Finger 7 3
  • EC 2.3.2.27 4
  • EC 6.3.2 61
  • AXO 3

External Ids for MARCH7 Gene

Previous HGNC Symbols for MARCH7 Gene

  • AXOT

Previous GeneCards Identifiers for MARCH7 Gene

  • GC02P160395
  • GC02P160277
  • GC02P160569
  • GC02P152452

Summaries for MARCH7 Gene

Entrez Gene Summary for MARCH7 Gene

  • MARCH7 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Mar 2010]

GeneCards Summary for MARCH7 Gene

MARCH7 (Membrane Associated Ring-CH-Type Finger 7) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is MARCH10.

UniProtKB/Swiss-Prot for MARCH7 Gene

  • E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Gene Wiki entry for MARCH7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH7 Gene

Genomics for MARCH7 Gene

Regulatory Elements for MARCH7 Gene

Enhancers for MARCH7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G159612 1.4 ENCODE dbSUPER 15.7 -97.2 -97211 6.2 PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 FEZF1 ZNF2 ZBTB7B MARCH7 BAZ2B LOC643072 LY75 ENSG00000226266 ENSG00000207117
GH02G159505 1.1 Ensembl ENCODE dbSUPER 17.7 -205.9 -205900 2.2 ZNF680 GATA3 JUND HNF4A FOS PRDM1 MAFK MARCH7 ENSG00000226266 ENSG00000207117 LOC100422294 ENSG00000225369
GH02G159605 1.1 Ensembl ENCODE dbSUPER 15.7 -106.3 -106257 0.8 HLF ZNF175 MAX RAD21 NR2F2 PRDM6 GATA3 ZNF18 MARCH7 BAZ2B LOC643072 ENSG00000226266 ENSG00000207117
GH02G159710 1.4 ENCODE dbSUPER 12.2 +0.5 544 5.0 CREB3L1 AGO1 ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ENSG00000226266 LOC643072 MARCH7 LY75 BAZ2B CD302 PLA2R1 GC02P159769
GH02G159515 1.5 FANTOM5 ENCODE dbSUPER 9.5 -196.3 -196253 2.0 MLX YY1 GATA2 CBX5 FOS ZNF263 YY2 REST TBX21 ZNF518A BAZ2B MARCH7 CD302 LY75 ENSG00000207117 LOC100422294 ENSG00000225369
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MARCH7 on UCSC Golden Path with GeneCards custom track

Promoters for MARCH7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000125195 243 2601 CREB3L1 AGO1 ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for MARCH7 Gene

Chromosome:
2
Start:
159,712,457 bp from pter
End:
159,771,027 bp from pter
Size:
58,571 bases
Orientation:
Plus strand

Genomic View for MARCH7 Gene

Genes around MARCH7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCH7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCH7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH7 Gene

Proteins for MARCH7 Gene

  • Protein details for MARCH7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H992-MARH7_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MARCH7
    Protein Accession:
    Q9H992
    Secondary Accessions:
    • A8K9X1
    • B7Z7P5
    • D3DPB0
    • Q53GQ1
    • Q9BTR9

    Protein attributes for MARCH7 Gene

    Size:
    704 amino acids
    Molecular mass:
    78051 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MARCH7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARCH7 Gene

Selected DME Specific Peptides for MARCH7 Gene

Q9H992:
  • ITVDIIPSGW
  • PCKCTGS
  • EEEGDLCRICQ
  • SSTNHQLPS
  • GPWLSSSLRNRCTPLFSRRRREGRDESSR
  • QQRDHDSKRPKLSCTNC
  • GILPGSLFRFAVPPALGSNL

Post-translational modifications for MARCH7 Gene

  • Ubiquitination at Lys536, Lys571, and Lys608
  • Modification sites at PhosphoSitePlus

Domains & Families for MARCH7 Gene

Protein Domains for MARCH7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H992

UniProtKB/Swiss-Prot:

MARH7_HUMAN :
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
Domain:
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
genes like me logo Genes that share domains with MARCH7: view

No data available for Suggested Antigen Peptide Sequences for MARCH7 Gene

Function for MARCH7 Gene

Molecular function for MARCH7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for MARCH7 Gene

Gene Ontology (GO) - Molecular Function for MARCH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MARCH7: view
genes like me logo Genes that share phenotypes with MARCH7: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MARCH7 Gene

Localization for MARCH7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARCH7 gene
Compartment Confidence
plasma membrane 4
cytosol 4
cytoskeleton 3
nucleus 3
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
golgi apparatus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MARCH7 Gene

Pathways & Interactions for MARCH7 Gene

SuperPathways for MARCH7 Gene

No Data Available

UniProtKB/Swiss-Prot Q9H992-MARH7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MARCH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002643 regulation of tolerance induction IEA --
GO:0016567 protein ubiquitination IEA --
GO:0042130 negative regulation of T cell proliferation IEA --
genes like me logo Genes that share ontologies with MARCH7: view

No data available for Pathways by source and SIGNOR curated interactions for MARCH7 Gene

Drugs & Compounds for MARCH7 Gene

(3) Drugs for MARCH7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for MARCH7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with MARCH7: view

Transcripts for MARCH7 Gene

Unigene Clusters for MARCH7 Gene

Membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13
SP1:
SP2: -
SP3: -
SP4:
SP5: - - -
SP6: - -
SP7:

Relevant External Links for MARCH7 Gene

GeneLoc Exon Structure for
MARCH7
ECgene alternative splicing isoforms for
MARCH7

Expression for MARCH7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MARCH7 Gene

Protein differential expression in normal tissues from HIPED for MARCH7 Gene

This gene is overexpressed in Placenta (48.3) and Testis (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MARCH7 Gene



Protein tissue co-expression partners for MARCH7 Gene

- Elite partner

SOURCE GeneReport for Unigene cluster for MARCH7 Gene:

Hs.529272

Evidence on tissue expression from TISSUES for MARCH7 Gene

  • Nervous system(4.5)
  • Skin(4.4)
  • Liver(4.3)
  • Muscle(2.6)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with MARCH7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARCH7 Gene

Orthologs for MARCH7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCH7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARCH7 34 35
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia MARCH7 34 35
  • 92.76 (n)
cow
(Bos Taurus)
Mammalia MARCH7 34 35
  • 91.3 (n)
rat
(Rattus norvegicus)
Mammalia March7 34
  • 87.87 (n)
mouse
(Mus musculus)
Mammalia March7 34 16 35
  • 87.43 (n)
oppossum
(Monodelphis domestica)
Mammalia MARCH7 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MARCH7 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves MARCH7 34 35
  • 72.19 (n)
lizard
(Anolis carolinensis)
Reptilia MARCH7 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia march7 34
  • 60.45 (n)
Str.2990 34
zebrafish
(Danio rerio)
Actinopterygii march7 34 35 35
  • 51.52 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12853 34
Species where no ortholog for MARCH7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARCH7 Gene

ENSEMBL:
Gene Tree for MARCH7 (if available)
TreeFam:
Gene Tree for MARCH7 (if available)

Paralogs for MARCH7 Gene

Paralogs for MARCH7 Gene

(2) SIMAP similar genes for MARCH7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MARCH7: view

Variants for MARCH7 Gene

Sequence variations from dbSNP and Humsavar for MARCH7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000098893 -- 159,731,092(+) TTTCG(C/T)TATGT intron-variant
rs1000185884 -- 159,734,488(+) TGAAA(A/G)CAGTT intron-variant
rs1000249244 -- 159,765,820(+) AAAGG(A/C)GTCAG intron-variant
rs1000279255 -- 159,725,411(+) TTTTG(A/G)TTTGC intron-variant
rs1000476570 -- 159,729,492(+) ATGAC(A/G)AAACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH7 Gene

Variant ID Type Subtype PubMed ID
esv2443442 CNV deletion 19546169
nsv1010774 CNV gain 25217958
nsv470497 CNV loss 18288195
nsv834436 CNV loss 17160897

Variation tolerance for MARCH7 Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MARCH7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MARCH7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH7 Gene

Disorders for MARCH7 Gene

Relevant External Links for MARCH7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MARCH7

No disorders were found for MARCH7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MARCH7 Gene

Publications for MARCH7 Gene

  1. E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. (PMID: 16868077) Flierman D. … Chau V. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 22 64
  2. The E3 ligase axotrophin/MARCH-7: protein expression profiling of human tissues reveals links to adult stem cells. (PMID: 19901269) Szigyarto C.A. … Metcalfe S.M. (J. Histochem. Cytochem. 2010) 3 22 64
  3. Evidence for functional inter-relationships between FOXP3, leukaemia inhibitory factor, and axotrophin/MARCH-7 in transplantation tolerance. (PMID: 17161353) Muthukumarana P.A. … Metcalfe S.M. (Int. Immunopharmacol. 2006) 3 22 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  5. Leukaemia inhibitory factor (LIF) is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance. (PMID: 15670816) Metcalfe S.M. … Lyons G.E. (FEBS Lett. 2005) 3 4 64

Products for MARCH7 Gene

Sources for MARCH7 Gene

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