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Aliases for MARCH7 Gene

Aliases for MARCH7 Gene

  • Membrane-Associated Ring Finger (C3HC4) 7, E3 Ubiquitin Protein Ligase 2 3
  • Axotrophin 2 3 4
  • Membrane-Associated RING Finger Protein 7 3 4
  • Membrane-Associated RING-CH Protein VII 3 4
  • RING Finger Protein 177 3 4
  • MARCH-VII 3 4
  • RNF177 3 4
  • AXOT 3 4
  • Membrane-Associated Ring Finger (C3HC4) 7 2
  • E3 Ubiquitin-Protein Ligase MARCH7 3
  • EC 6.3.2.- 4
  • EC 6.3.2 63
  • AXO 3

External Ids for MARCH7 Gene

Previous HGNC Symbols for MARCH7 Gene

  • AXOT

Previous GeneCards Identifiers for MARCH7 Gene

  • GC02P160395
  • GC02P160277
  • GC02P160569
  • GC02P152452

Summaries for MARCH7 Gene

Entrez Gene Summary for MARCH7 Gene

  • MARCH7 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Mar 2010]

GeneCards Summary for MARCH7 Gene

MARCH7 (Membrane-Associated Ring Finger (C3HC4) 7, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is MARCH10.

UniProtKB/Swiss-Prot for MARCH7 Gene

  • E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Gene Wiki entry for MARCH7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH7 Gene

Genomics for MARCH7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MARCH7 Gene

159,712,457 bp from pter
159,771,027 bp from pter
58,571 bases
Plus strand

Genomic View for MARCH7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARCH7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH7 Gene

Proteins for MARCH7 Gene

  • Protein details for MARCH7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase MARCH7
    Protein Accession:
    Secondary Accessions:
    • A8K9X1
    • B7Z7P5
    • D3DPB0
    • Q53GQ1
    • Q9BTR9

    Protein attributes for MARCH7 Gene

    704 amino acids
    Molecular mass:
    78051 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MARCH7 Gene


neXtProt entry for MARCH7 Gene

Proteomics data for MARCH7 Gene at MOPED

Post-translational modifications for MARCH7 Gene

  • Ubiquitination at Lys536, Lys571, and Lys608
  • Modification sites at PhosphoSitePlus

Domains for MARCH7 Gene

Gene Families for MARCH7 Gene

  • MARCH :MARCH membrane-associated ring fingers
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for MARCH7 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q9H992
  • The RING-CH-type zinc finger domain is required for E3 ligase activity
  • Contains 1 RING-CH-type zinc finger.
genes like me logo Genes that share domains with MARCH7: view

No data available for Suggested Antigen Peptide Sequences for MARCH7 Gene

Function for MARCH7 Gene

Molecular function for MARCH7 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for MARCH7 Gene

Gene Ontology (GO) - Molecular Function for MARCH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with MARCH7: view

Phenotypes for MARCH7 Gene

genes like me logo Genes that share phenotypes with MARCH7: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MARCH7 Gene

Localization for MARCH7 Gene

Subcellular locations from

Jensen Localization Image for MARCH7 Gene COMPARTMENTS Subcellular localization image for MARCH7 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
plasma membrane 4
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 2
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MARCH7 Gene

Pathways for MARCH7 Gene

SuperPathways for MARCH7 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9H992-MARH7_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for MARCH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MARCH7: view

No data available for Pathways by source for MARCH7 Gene

Compounds for MARCH7 Gene

(4) HMDB Compounds for MARCH7 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
Phosphoric acid
  • acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion
genes like me logo Genes that share compounds with MARCH7: view

Transcripts for MARCH7 Gene

Unigene Clusters for MARCH7 Gene

Membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MARCH7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13
SP2: -
SP3: -
SP5: - - -
SP6: - -

Relevant External Links for MARCH7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MARCH7 Gene

mRNA expression in normal human tissues for MARCH7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MARCH7 Gene

This gene is overexpressed in Placenta (48.3) and Testis (20.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MARCH7 Gene

SOURCE GeneReport for Unigene cluster for MARCH7 Gene Hs.529272

genes like me logo Genes that share expressions with MARCH7: view

Expression partners for MARCH7 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MARCH7 Gene

Orthologs for MARCH7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCH7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MARCH7 35
  • 91.3 (n)
  • 88.67 (a)
  • 88 (a)
(Canis familiaris)
Mammalia MARCH7 35
  • 92.76 (n)
  • 91.62 (a)
  • 91 (a)
(Mus musculus)
Mammalia March7 35
  • 87.43 (n)
  • 86.03 (a)
March7 16
March7 36
  • 86 (a)
(Pan troglodytes)
Mammalia MARCH7 35
  • 99.81 (n)
  • 99.86 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia March7 35
  • 87.87 (n)
  • 87.63 (a)
(Monodelphis domestica)
Mammalia MARCH7 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia MARCH7 36
  • 69 (a)
(Gallus gallus)
Aves MARCH7 35
  • 72.19 (n)
  • 68.39 (a)
  • 62 (a)
(Anolis carolinensis)
Reptilia MARCH7 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia march7 35
  • 60.45 (n)
  • 57.25 (a)
Str.2990 35
(Danio rerio)
Actinopterygii march7 35
  • 51.52 (n)
  • 47.77 (a)
march7 36
  • 69 (a)
march7 36
  • 38 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12853 35
Species with no ortholog for MARCH7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARCH7 Gene

Gene Tree for MARCH7 (if available)
Gene Tree for MARCH7 (if available)

Paralogs for MARCH7 Gene

Paralogs for MARCH7 Gene

Selected SIMAP similar genes for MARCH7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MARCH7: view

Variants for MARCH7 Gene

Sequence variations from dbSNP and Humsavar for MARCH7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs12805 -- 159,767,777(-) taaaa(A/G)aaaaa utr-variant-3-prime, nc-transcript-variant
rs14763 -- 159,768,098(-) TTTTT(A/T)AAACC utr-variant-3-prime, nc-transcript-variant
rs1365802 -- 159,752,651(-) CAACA(A/G)TCTAT intron-variant
rs1365803 -- 159,748,757(-) GCTGG(A/G)GGGAC synonymous-codon, reference, nc-transcript-variant
rs1427328 -- 159,762,064(-) GCTAC(C/T)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH7 Gene

Variant ID Type Subtype PubMed ID
dgv4351n71 CNV Loss 21882294
nsv875344 CNV Loss 21882294
nsv470497 CNV Loss 18288195
nsv834436 CNV Loss 17160897
esv2443442 CNV Deletion 19546169

Relevant External Links for MARCH7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH7 Gene

Disorders for MARCH7 Gene

(1) Novoseek inferred disease relationships for MARCH7 Gene

Disease -log(P) Hits PubMed IDs
leukemia 56.1 4
genes like me logo Genes that share disorders with MARCH7: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for MARCH7 Gene

Publications for MARCH7 Gene

  1. E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. (PMID: 16868077) Flierman D. … Chau V. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 23
  2. Evidence for functional inter-relationships between FOXP3, leukaemia inhibitory factor, and axotrophin/MARCH-7 in transplantation tolerance. (PMID: 17161353) Muthukumarana P.A. … Metcalfe S.M. (Int. Immunopharmacol. 2006) 3 23
  3. The E3 ligase axotrophin/MARCH-7: protein expression profiling of human tissues reveals links to adult stem cells. (PMID: 19901269) Szigyarto C.A. … Metcalfe S.M. (J. Histochem. Cytochem. 2010) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E. … Frueh K. (J. Virol. 2004) 2 3

Products for MARCH7 Gene

Sources for MARCH7 Gene

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