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Aliases for MARCH7 Gene

Aliases for MARCH7 Gene

  • Membrane Associated Ring-CH-Type Finger 7 2 3 5
  • Axotrophin 2 3 4
  • Membrane-Associated Ring Finger (C3HC4) 7, E3 Ubiquitin Protein Ligase 2 3
  • Membrane-Associated RING Finger Protein 7 3 4
  • Membrane-Associated RING-CH Protein VII 3 4
  • RING Finger Protein 177 3 4
  • MARCH-VII 3 4
  • RNF177 3 4
  • AXOT 3 4
  • Membrane-Associated Ring Finger (C3HC4) 7 2
  • Membrane Associated Ring Finger 7 3
  • EC 6.3.2.- 4
  • EC 6.3.2 63
  • AXO 3

External Ids for MARCH7 Gene

Previous HGNC Symbols for MARCH7 Gene

  • AXOT

Previous GeneCards Identifiers for MARCH7 Gene

  • GC02P160395
  • GC02P160277
  • GC02P160569
  • GC02P152452

Summaries for MARCH7 Gene

Entrez Gene Summary for MARCH7 Gene

  • MARCH7 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Mar 2010]

GeneCards Summary for MARCH7 Gene

MARCH7 (Membrane Associated Ring-CH-Type Finger 7) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is MARCH10.

UniProtKB/Swiss-Prot for MARCH7 Gene

  • E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Gene Wiki entry for MARCH7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH7 Gene

Genomics for MARCH7 Gene

Regulatory Elements for MARCH7 Gene

Promoters for MARCH7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MARCH7 on UCSC Golden Path with GeneCards custom track

Genomic Location for MARCH7 Gene

Chromosome:
2
Start:
159,712,457 bp from pter
End:
159,771,027 bp from pter
Size:
58,571 bases
Orientation:
Plus strand

Genomic View for MARCH7 Gene

Genes around MARCH7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCH7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCH7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH7 Gene

Proteins for MARCH7 Gene

  • Protein details for MARCH7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H992-MARH7_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MARCH7
    Protein Accession:
    Q9H992
    Secondary Accessions:
    • A8K9X1
    • B7Z7P5
    • D3DPB0
    • Q53GQ1
    • Q9BTR9

    Protein attributes for MARCH7 Gene

    Size:
    704 amino acids
    Molecular mass:
    78051 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MARCH7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARCH7 Gene

Proteomics data for MARCH7 Gene at MOPED

Post-translational modifications for MARCH7 Gene

  • Ubiquitination at Lys 536, Lys 571, and Lys 608
  • Modification sites at PhosphoSitePlus

Domains & Families for MARCH7 Gene

Protein Domains for MARCH7 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H992

UniProtKB/Swiss-Prot:

MARH7_HUMAN :
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
  • Contains 1 RING-CH-type zinc finger.
Domain:
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
Similarity:
  • Contains 1 RING-CH-type zinc finger.
genes like me logo Genes that share domains with MARCH7: view

No data available for Suggested Antigen Peptide Sequences for MARCH7 Gene

Function for MARCH7 Gene

Molecular function for MARCH7 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for MARCH7 Gene

Gene Ontology (GO) - Molecular Function for MARCH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with MARCH7: view
genes like me logo Genes that share phenotypes with MARCH7: view

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MARCH7 Gene

Localization for MARCH7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MARCH7 Gene COMPARTMENTS Subcellular localization image for MARCH7 gene
Compartment Confidence
cytosol 4
cytoskeleton 3
nucleus 3
plasma membrane 3
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MARCH7 Gene

Pathways & Interactions for MARCH7 Gene

SuperPathways for MARCH7 Gene

No Data Available

UniProtKB/Swiss-Prot Q9H992-MARH7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MARCH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002643 regulation of tolerance induction IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MARCH7: view

No data available for Pathways by source and SIGNOR curated interactions for MARCH7 Gene

Drugs & Compounds for MARCH7 Gene

(3) Drugs for MARCH7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for MARCH7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with MARCH7: view

Transcripts for MARCH7 Gene

Unigene Clusters for MARCH7 Gene

Membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13
SP1:
SP2: -
SP3: -
SP4:
SP5: - - -
SP6: - -
SP7:

Relevant External Links for MARCH7 Gene

GeneLoc Exon Structure for
MARCH7
ECgene alternative splicing isoforms for
MARCH7

Expression for MARCH7 Gene

mRNA expression in normal human tissues for MARCH7 Gene

Protein differential expression in normal tissues from HIPED for MARCH7 Gene

This gene is overexpressed in Placenta (48.3) and Testis (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MARCH7 Gene



SOURCE GeneReport for Unigene cluster for MARCH7 Gene Hs.529272

genes like me logo Genes that share expression patterns with MARCH7: view

Protein tissue co-expression partners for MARCH7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MARCH7 Gene

Orthologs for MARCH7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCH7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARCH7 35
  • 99.81 (n)
  • 99.86 (a)
MARCH7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MARCH7 36
  • 88 (a)
OneToOne
MARCH7 35
  • 91.3 (n)
  • 88.67 (a)
dog
(Canis familiaris)
Mammalia MARCH7 35
  • 92.76 (n)
  • 91.62 (a)
MARCH7 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia March7 16
March7 35
  • 87.43 (n)
  • 86.03 (a)
March7 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MARCH7 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MARCH7 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia March7 35
  • 87.87 (n)
  • 87.63 (a)
chicken
(Gallus gallus)
Aves MARCH7 35
  • 72.19 (n)
  • 68.39 (a)
MARCH7 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MARCH7 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia march7 35
  • 60.45 (n)
  • 57.25 (a)
Str.2990 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12853 35
zebrafish
(Danio rerio)
Actinopterygii march7 36
  • 69 (a)
OneToMany
march7 36
  • 38 (a)
OneToMany
march7 35
  • 51.52 (n)
  • 47.77 (a)
Species with no ortholog for MARCH7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARCH7 Gene

ENSEMBL:
Gene Tree for MARCH7 (if available)
TreeFam:
Gene Tree for MARCH7 (if available)

Paralogs for MARCH7 Gene

Paralogs for MARCH7 Gene

(2) SIMAP similar genes for MARCH7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MARCH7: view

Variants for MARCH7 Gene

Sequence variations from dbSNP and Humsavar for MARCH7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs17813964 - 159,743,206(+) CTGTA(C/G)TACCT nc-transcript-variant, reference, missense
rs16844275 - 159,747,868(+) GAGCA(C/T)TTTAC nc-transcript-variant, reference, missense
rs13024801 - 159,748,425(+) CTGAA(A/G)GTAGA nc-transcript-variant, reference, missense
rs12805 -- 159,767,777(-) taaaa(A/G)aaaaa nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs2059699 -- 159,765,228(-) GAGGA(A/C)CTACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH7 Gene

Variant ID Type Subtype PubMed ID
dgv4351n71 CNV Loss 21882294
nsv875344 CNV Loss 21882294
nsv470497 CNV Loss 18288195
nsv834436 CNV Loss 17160897
esv2443442 CNV Deletion 19546169

Variation tolerance for MARCH7 Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MARCH7 Gene

HapMap Linkage Disequilibrium report
MARCH7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH7 Gene

Disorders for MARCH7 Gene

Relevant External Links for MARCH7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MARCH7

No disorders were found for MARCH7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MARCH7 Gene

Publications for MARCH7 Gene

  1. E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. (PMID: 16868077) Flierman D. … Chau V. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 23 67
  2. The E3 ligase axotrophin/MARCH-7: protein expression profiling of human tissues reveals links to adult stem cells. (PMID: 19901269) Szigyarto C.A. … Metcalfe S.M. (J. Histochem. Cytochem. 2010) 3 23
  3. Evidence for functional inter-relationships between FOXP3, leukaemia inhibitory factor, and axotrophin/MARCH-7 in transplantation tolerance. (PMID: 17161353) Muthukumarana P.A. … Metcalfe S.M. (Int. Immunopharmacol. 2006) 3 23
  4. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E. … Frueh K. (J. Virol. 2004) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for MARCH7 Gene

Sources for MARCH7 Gene

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