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Aliases for MARCH6 Gene

Aliases for MARCH6 Gene

  • Membrane Associated Ring-CH-Type Finger 6 2 3 5
  • Membrane-Associated Ring Finger (C3HC4) 6, E3 Ubiquitin Protein Ligase 2 3
  • Membrane-Associated RING Finger Protein 6 3 4
  • Membrane-Associated RING-CH Protein VI 3 4
  • RING Finger Protein 176 3 4
  • Doa10 Homolog 3 4
  • MARCH-VI 3 4
  • RNF176 3 4
  • TEB4 3 4
  • Membrane-Associated RING-CH Finger Protein 6 3
  • Membrane-Associated Ring Finger (C3HC4) 6 2
  • Membrane Associated Ring Finger 6 3
  • Protein TEB-4 4
  • EC 6.3.2.- 4
  • KIAA0597 4
  • DOA10 3

External Ids for MARCH6 Gene

Previous GeneCards Identifiers for MARCH6 Gene

  • GC05P010408

Summaries for MARCH6 Gene

Entrez Gene Summary for MARCH6 Gene

  • This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for MARCH6 Gene

MARCH6 (Membrane Associated Ring-CH-Type Finger 6) is a Protein Coding gene. Diseases associated with MARCH6 include intrahepatic cholestasis. Among its related pathways are Protein processing in endoplasmic reticulum. GO annotations related to this gene include enzyme binding and ubiquitin-protein transferase activity. An important paralog of this gene is MARCH2.

UniProtKB/Swiss-Prot for MARCH6 Gene

  • E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.

Gene Wiki entry for MARCH6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH6 Gene

Genomics for MARCH6 Gene

Regulatory Elements for MARCH6 Gene

Enhancers for MARCH6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MARCH6 on UCSC Golden Path with GeneCards custom track

Promoters for MARCH6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MARCH6 on UCSC Golden Path with GeneCards custom track

Genomic Location for MARCH6 Gene

Chromosome:
5
Start:
10,353,639 bp from pter
End:
10,440,388 bp from pter
Size:
86,750 bases
Orientation:
Plus strand

Genomic View for MARCH6 Gene

Genes around MARCH6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCH6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH6 Gene

Proteins for MARCH6 Gene

  • Protein details for MARCH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60337-MARH6_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MARCH6
    Protein Accession:
    O60337
    Secondary Accessions:
    • A5PKZ4
    • B4DKJ2
    • B4DT33
    • D3DTC8
    • O14670
    • Q86X77

    Protein attributes for MARCH6 Gene

    Size:
    910 amino acids
    Molecular mass:
    102545 Da
    Quaternary structure:
    • Interacts with DIO2.
    SequenceCaution:
    • Sequence=AAB66840.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAB66840.1; Type=Frameshift; Positions=381, 382, 383, 385, 391, 396, 418; Evidence={ECO:0000305}; Sequence=BAA25523.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MARCH6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARCH6 Gene

Proteomics data for MARCH6 Gene at MOPED

Post-translational modifications for MARCH6 Gene

  • Auto-ubiquitinated, which results in proteasomal degradation.
  • Ubiquitination at Lys 20, Lys 33, Lys 45, Lys 49, Lys 56, Lys 550, Lys 881, Lys 894, and Lys 897
  • Modification sites at PhosphoSitePlus

Other Protein References for MARCH6 Gene

No data available for DME Specific Peptides for MARCH6 Gene

Domains & Families for MARCH6 Gene

Protein Domains for MARCH6 Gene

Graphical View of Domain Structure for InterPro Entry

O60337

UniProtKB/Swiss-Prot:

MARH6_HUMAN :
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
  • Contains 1 RING-CH-type zinc finger.
Domain:
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
Similarity:
  • Contains 1 RING-CH-type zinc finger.
genes like me logo Genes that share domains with MARCH6: view

No data available for Suggested Antigen Peptide Sequences for MARCH6 Gene

Function for MARCH6 Gene

Molecular function for MARCH6 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.

Enzyme Numbers (IUBMB) for MARCH6 Gene

Gene Ontology (GO) - Molecular Function for MARCH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway TAS 16373356
genes like me logo Genes that share ontologies with MARCH6: view
genes like me logo Genes that share phenotypes with MARCH6: view

Animal Model Products

miRNA for MARCH6 Gene

miRTarBase miRNAs that target MARCH6

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MARCH6 Gene

Localization for MARCH6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCH6 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MARCH6 Gene COMPARTMENTS Subcellular localization image for MARCH6 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 1

Gene Ontology (GO) - Cellular Components for MARCH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IDA 16373356
genes like me logo Genes that share ontologies with MARCH6: view

Pathways & Interactions for MARCH6 Gene

genes like me logo Genes that share pathways with MARCH6: view

Pathways by source for MARCH6 Gene

1 KEGG pathway for MARCH6 Gene

UniProtKB/Swiss-Prot O60337-MARH6_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MARCH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010498 proteasomal protein catabolic process IDA 15673284
genes like me logo Genes that share ontologies with MARCH6: view

No data available for SIGNOR curated interactions for MARCH6 Gene

Drugs & Compounds for MARCH6 Gene

(3) Drugs for MARCH6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for MARCH6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with MARCH6: view

Transcripts for MARCH6 Gene

Unigene Clusters for MARCH6 Gene

Membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
SP1: - - - -
SP2:
SP3:
SP4: -
SP5:
SP6: - -

ExUns: 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
SP1: - -
SP2:
SP3:
SP4:
SP5: -
SP6:

Relevant External Links for MARCH6 Gene

GeneLoc Exon Structure for
MARCH6
ECgene alternative splicing isoforms for
MARCH6

Expression for MARCH6 Gene

mRNA expression in normal human tissues for MARCH6 Gene

Protein differential expression in normal tissues from HIPED for MARCH6 Gene

This gene is overexpressed in Adrenal (56.7) and Liver (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MARCH6 Gene



SOURCE GeneReport for Unigene cluster for MARCH6 Gene Hs.432862

mRNA Expression by UniProt/SwissProt for MARCH6 Gene

O60337-MARH6_HUMAN
Tissue specificity: Present in brain (at protein level).
genes like me logo Genes that share expression patterns with MARCH6: view

Protein tissue co-expression partners for MARCH6 Gene

- Elite partner

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MARCH6 Gene

Orthologs for MARCH6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MARCH6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MARCH6 35
  • 92.56 (n)
  • 98.35 (a)
MARCH6 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MARCH6 35
  • 93.73 (n)
  • 98.46 (a)
MARCH6 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia March6 35
  • 90.68 (n)
  • 98.33 (a)
March6 16
March6 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MARCH6 35
  • 99.89 (n)
  • 100 (a)
MARCH6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia March6 35
  • 90.31 (n)
  • 98.11 (a)
oppossum
(Monodelphis domestica)
Mammalia MARCH6 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MARCH6 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves MARCH6 35
  • 83.39 (n)
  • 94.2 (a)
MARCH6 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MARCH6 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia march6 35
  • 80.01 (n)
  • 90.97 (a)
Str.11781 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14661 35
zebrafish
(Danio rerio)
Actinopterygii Dr.26548 35
march6 35
  • 76.19 (n)
  • 90.18 (a)
march6 36
  • 89 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7694 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007204 35
  • 56.4 (n)
  • 58.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1317 35
  • 55.63 (n)
  • 53.45 (a)
CG1317 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea marc-6 35
  • 53.33 (n)
  • 44.14 (a)
marc-6 36
  • 37 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSM4 36
  • 17 (a)
OneToMany
SSM4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G34100 35
  • 46.05 (n)
  • 34.33 (a)
rice
(Oryza sativa)
Liliopsida Os06g0639000 35
  • 45.14 (n)
  • 33.18 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2510 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for MARCH6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARCH6 Gene

ENSEMBL:
Gene Tree for MARCH6 (if available)
TreeFam:
Gene Tree for MARCH6 (if available)

Paralogs for MARCH6 Gene

Paralogs for MARCH6 Gene

(4) SIMAP similar genes for MARCH6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MARCH6: view

Variants for MARCH6 Gene

Sequence variations from dbSNP and Humsavar for MARCH6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1062914 - 10,411,506(+) TCAGC(C/T)TTACC nc-transcript-variant, reference, missense
rs7761 -- 10,435,238(+) CAACA(A/G)TTTTT nc-transcript-variant, utr-variant-3-prime
rs9544 -- 10,435,036(+) CGTAA(A/G)GGTAG nc-transcript-variant, utr-variant-3-prime
rs2640707 -- 10,400,001(+) tcagg(C/T)tGAAT intron-variant, upstream-variant-2KB
rs2640708 -- 10,405,977(+) ATGGC(C/T)GCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH6 Gene

Variant ID Type Subtype PubMed ID
nsv880520 CNV Gain 21882294
nsv880973 CNV Gain 21882294
nsv4713 CNV Loss 18451855
esv273891 CNV Insertion 20981092
esv271970 CNV Insertion 20981092

Variation tolerance for MARCH6 Gene

Residual Variation Intolerance Score: 4.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MARCH6 Gene

HapMap Linkage Disequilibrium report
MARCH6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH6 Gene

Disorders for MARCH6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MARCH6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
intrahepatic cholestasis
  • intrahepatic cholestasis of pregnancy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MARCH6

Genetic Association Database (GAD)
MARCH6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MARCH6
genes like me logo Genes that share disorders with MARCH6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARCH6 Gene

Publications for MARCH6 Gene

  1. A novel locus for body mass index on 5p15.2: a meta-analysis of two genome-wide association studies. (PMID: 22446040) Wang K.S. … Callahan K. (Gene 2012) 3 48 67
  2. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E. … Frueh K. (J. Virol. 2004) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway. (PMID: 24449766) Zelcer N. … Brown A.J. (Mol. Cell. Biol. 2014) 3

Products for MARCH6 Gene

Sources for MARCH6 Gene

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