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MARCH6 Gene

protein-coding   GIFtS: 53
GCID: GC05P010353

Membrane-Associated Ring Finger (C3HC4) 6, E3 Ubiquitin...

(Previous name: membrane-associated ring finger (C3HC4) 6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Membrane-Associated Ring Finger (C3HC4) 6, E3 Ubiquitin Protein
Ligase1 2
     DOA102 5
TEB42 3 5     KIAA05973 5
Doa10 Homolog2 3     Membrane-Associated Ring Finger (C3HC4) 61
Membrane-Associated RING Finger Protein 62 3     E3 Ubiquitin-Protein Ligase MARCH62
Membrane-Associated RING-CH Protein VI2 3     Membrane-Associated RING-CH Finger Protein 62
MARCH-VI2 3     EC 6.3.2.-3
RNF1762 3     Protein TEB-43
RING Finger Protein 1762 3     

External Ids:    HGNC: 305501   Entrez Gene: 102992   Ensembl: ENSG000001454957   OMIM: 6132975   UniProtKB: O603373   

Export aliases for MARCH6 gene to outside databases

Previous GC identifer: GC05P010408


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MARCH6 Gene:
This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc
finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in
thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been
observed for this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for MARCH6 Gene:
MARCH6 (membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with MARCH6 include intrahepatic cholestasis, and cholestasis. GO annotations related to this gene include ubiquitin-protein ligase activity and ubiquitin conjugating enzyme binding. An important paralog of this gene is MARCH8.

UniProtKB/Swiss-Prot: MARH6_HUMAN, O60337
Function: E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3
ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then
directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1

Gene Wiki entry for MARCH6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_006576.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MARCH6 gene promoter:
         FOXD3   CUTL1   Evi-1   Gfi-1   MEF-2A   Cart-1   ZIC2/Zic2   aMEF-2   Zic3   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MARCH6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARCH6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.2   Ensembl cytogenetic band:  5p15.2   HGNC cytogenetic band: 5p15.2

MARCH6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCH6 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P010353:  view genomic region     (about GC identifiers)

Start:
10,353,815 bp from pter      End:
10,440,500 bp from pter
Size:
86,686 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MARH6_HUMAN, O60337 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MARCH6  
Size: 910 amino acids; 102545 Da
Subunit: Interacts with DIO2
Sequence caution: Sequence=AAB66840.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAB66840.1; Type=Frameshift; Positions=381, 382, 383, 385, 391, 396, 418; Sequence=BAA25523.1;
Type=Erroneous initiation;
Secondary accessions: A5PKZ4 B4DKJ2 B4DT33 D3DTC8 O14670 Q86X77
Alternative splicing: 3 isoforms:  O60337-4   O60337-5   O60337-6   

Explore the universe of human proteins at neXtProt for MARCH6: NX_O60337

Explore proteomics data for MARCH6 at MOPED

Post-translational modifications: 

  • Auto-ubiquitinated, which results in proteasomal degradation1
  • Ubiquitination2 at Lys20, Lys33, Lys45, Lys49, Lys56, Lys550, Lys881, Lys894, Lys897
  • Modification sites at PhosphoSitePlus

  • See MARCH6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001257589.1  NP_001257590.1  NP_005876.2  

    ENSEMBL proteins: 
     ENSP00000414643   ENSP00000426000   ENSP00000425930   ENSP00000274140   ENSP00000424512  

    MARCH6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MARCH6
    GenScript Custom Purified and Recombinant Proteins Services for MARCH6
    Novus Biologicals MARCH6 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    MARCH6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MARCH6
    OriGene Custom Antibody Services for MARCH6
    Novus Biologicals MARCH6 Antibodies
    Search for Antibodies for MARCH6 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for MARCH6
    Search LSBio for Antibodies for MARCH6

    MARCH6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MARCH6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MARCH6
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers
    MARCH: MARCH membrane-associated ring fingers

    2 InterPro protein domains:
     IPR013083 Znf_RING/FYVE/PHD
     IPR011016 Znf_RING-CH

    Graphical View of Domain Structure for InterPro Entry O60337

    ProtoNet protein and cluster: O60337

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB011016 RINGv


    UniProtKB/Swiss-Prot: MARH6_HUMAN, O60337
    Domain: The RING-CH-type zinc finger domain is required for E3 ligase activity
    Similarity: Contains 1 RING-CH-type zinc finger


    MARCH6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARH6_HUMAN, O60337
    Function: E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3
    ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then
    directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IMP19651899
    GO:0008270zinc ion binding IEA--
    GO:0019899enzyme binding IPI19651899
    GO:0031624ubiquitin conjugating enzyme binding IPI15673284
    GO:0046872metal ion binding ----
         
    MARCH6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MARCH6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MARCH6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARCH6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARCH6

    miRNA
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    miRTarBase miRNAs that target MARCH6:
    hsa-mir-25-3p (MIRT050267), hsa-mir-16-5p (MIRT051174), hsa-let-7b-5p (MIRT052052)

    Block miRNA regulation of human, mouse, rat MARCH6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MARCH6 (see all 47):
    hsa-miR-142-5p hsa-miR-549 hsa-miR-3607-3p hsa-miR-429 hsa-miR-300 hsa-miR-106a hsa-miR-30d hsa-miR-374c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MARCH6
    Predesigned siRNA for gene silencing in human, mouse, rat MARCH6

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for MARCH6 (see all 7)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MARCH6
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH6

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MARCH6 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MARH6_HUMAN, O60337: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030176integral component of endoplasmic reticulum membrane IDA15673284

    MARCH6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MARCH6 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for MARCH6):
        Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: MARH6_HUMAN, O60337
    Pathway: Protein modification; protein ubiquitination


    MARCH6 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MARCH6: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MARCH6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MARCH6 (O603373 ENSP000002741404) via UniProtKB, MINT, STRING, and/or I2D (see all 109)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463793I2D: score=3 
    ENSG00000096155P463793I2D: score=3 
    ENSG00000227761P463793I2D: score=3 
    ENSG00000228760P463793I2D: score=3 
    ENSG00000229524P463793I2D: score=3 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070936protein K48-linked ubiquitination IDA15673284

    MARCH6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MARCH6 (MARH6)

    4 HMDB Compounds for MARCH6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MARCH6 gene (3 alternative transcripts): 
    NM_001270660.1  NM_001270661.1  NM_005885.3  

    Unigene Cluster for MARCH6:

    Membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
    Hs.432862  [show with all ESTs]
    Unigene Representative Sequence: NM_005885
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449913 ENST00000502795 ENST00000511802(uc003jeu.1) ENST00000503788
    ENST00000274140(uc003jet.1 uc011cmu.1 uc011cmv.1) ENST00000510872
    ENST00000507863 ENST00000506131 ENST00000514961 ENST00000510792 ENST00000512449
    ENST00000505253 ENST00000514312 ENST00000606497
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MARCH6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MARCH6 (see all 47):
    hsa-miR-142-5p hsa-miR-549 hsa-miR-3607-3p hsa-miR-429 hsa-miR-300 hsa-miR-106a hsa-miR-30d hsa-miR-374c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MARCH6
    Predesigned siRNA for gene silencing in human, mouse, rat MARCH6
    Clone
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    OriGene clones in human, mouse for MARCH6 (see all 7)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MARCH6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH6
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MARCH6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARCH6
      QuantiTect SYBR Green Assays in human, mouse, rat MARCH6
      QuantiFast Probe-based Assays in human, mouse, rat MARCH6

    Additional mRNA sequence: 

    AB011169.1 AF009301.1 AF056433.1 AF056443.1 AK000970.1 AK056198.1 AK296585.1 AK299339.1 
    AK300034.1 AK314686.1 AL080234.1 BC013761.1 BC039293.1 BC046148.1 BC111494.1 BC136461.1 
    BC136462.1 BC142679.1 BC142694.1 U52827.1 

    Selected DOTS entries (see all 29):

    DT.119034  DT.99952876  DT.445205  DT.100857110  DT.70102348  DT.120823752  DT.97846982  DT.100796722 
    DT.120823769  DT.120823828  DT.95153569  DT.95207519  DT.100640725  DT.40303889  DT.75184473  DT.92441774 
    DT.95153574  DT.100745545  DT.100796723  DT.100796724  DT.120823757  DT.120823781  DT.120823806  DT.86846100 

    Selected AceView cDNA sequences (see all 569):

    BU619114 BM833351 AI659023 CA445214 BG679503 BU070350 CB127200 BM680785 
    AA377235 Z39541 AA768646 BM717040 BC046148 BQ222098 BM784991 BF000409 
    H97052 CB321986 AA333322 BX646659 BG655844 BC013761 BC039293 CB069152 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MARCH6 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
    SP1:                                                                          -     -     -                                                                 -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                        -   
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
    SP1:        -                 -                           
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:        -                                             


    ECgene alternative splicing isoforms for MARCH6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MARCH6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTTTTTTG
    MARCH6 Expression
    About this image

    MARCH6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MARCH6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.432862

    UniProtKB/Swiss-Prot: MARH6_HUMAN, O60337
    Tissue specificity: Present in brain (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Array including MARCH6: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MARCH6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARCH6
    QuantiTect SYBR Green Assays in human, mouse, rat MARCH6
    QuantiFast Probe-based Assays in human, mouse, rat MARCH6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MARCH6 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia March61 , 5 membrane-associated ring finger (C3HC4) 61, 5 90.68(n)1
    98.33(a)1
      15 (12.95 cM)5
    2234551  NM_172606.21  NP_766194.21 
     314558995 
    chicken
    (Gallus gallus)
    Aves MARCH61 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin more 83.39(n)
    94.2(a)
      420927  XM_419012.4  XP_419012.3 
    lizard
    (Anolis carolinensis)
    Reptilia MARCH66
    membrane-associated ring finger (C3HC4) 6, E3 ubiq...
    93(a)
    1 ↔ 1
    4(66592396-66659776)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.146612 Xenopus laevis transcribed sequence with strong similarity more 79.03(n)    BJ064869.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.265482 Danio rerio, Similar to RIKEN cDNA F830029L24 gene, more 80.47(n)    BC047861.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG13171 CG1317 55.63(n)
    53.45(a)
      38300  NM_139458.4  NP_647715.2 
    worm
    (Caenorhabditis elegans)
    Secernentea marc-61 marc-6 53.33(n)
    44.14(a)
      172986  NM_060422.4  NP_492823.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSM4(YIL030C)4 Ubiquitin-protein ligase involved in ER-associated more   --   9(300009-296050) 854781  NP_012234.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G341001 AT4G34100 46.05(n)
    34.33(a)
      829556  NM_119571.4  NP_195136.3 
    rice
    (Oryza sativa)
    Liliopsida Os06g06390001 Os06g0639000 45.14(n)
    33.18(a)
      4341618  NM_001064692.1  NP_001058157.1 


    ENSEMBL Gene Tree for MARCH6 (if available)
    TreeFam Gene Tree for MARCH6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MARCH6 gene
    MARCH82  MARCH32  MARCH12  MARCH22  
    4 SIMAP similar genes for MARCH6 using alignment to 2 protein entries:     MARH6_HUMAN (see all proteins):
    MARCH1    MARCH10    MARCH3    MARCH7

    MARCH6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MARCH6 (see all 1647)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs133561451,2
    C,F--10351780(+) AGCCAC/TAGGGG 3 -- us2k111Minor allele frequency- T:0.38NS NA WA CSA EA 446
    rs1869090221,2
    --10351907(+) AGAGAA/GGTGTG 3 -- us2k10--------
    rs1910326711,2
    --10351922(+) ATTCAG/TGTATT 3 -- us2k10--------
    rs77204901,2
    C,F,A,H--10352123(+) CTAAAG/TACAAA 3 -- us2k128Minor allele frequency- T:0.36NS EA NA WA CSA 2711
    rs1840697301,2
    --10352334(+) ATACGC/TGCTCT 3 -- us2k10--------
    rs789565481,2
    C,F--10352369(+) AGCTCT/CTGGAG 3 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1398516951,2
    C--10352622(+) AAAAA-/AAAA  
            
    AAAGA
    3 -- us2k10--------
    rs77052441,2
    C,F,H--10352786(+) GAGTGA/GCATCA 3 -- us2k16Minor allele frequency- G:0.10NS NA WA 906
    rs770705571,2
    F--10353011(+) TCTGAC/TGTGGC 3 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1453142251,2
    --10353012(+) CTGACA/GTGGCG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for MARCH6 (10353815 - 10440500 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MARCH6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv273891CNV Insertion20981092
    esv271970CNV Insertion20981092
    nsv4713CNV Loss18451855
    nsv880973CNV Gain21882294
    nsv880520CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MARCH6
    DNA2.0 Custom Variant and Variant Library Synthesis for MARCH6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613297    OMIM disorders: --

    4 diseases for MARCH6:    
    About MalaCards
    intrahepatic cholestasis    cholestasis    thyroiditis    malaria


    MARCH6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MARCH6

    Export disorders for MARCH6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MARCH6 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with MARCH6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel locus for body mass index on 5p15.2: a meta-analysis of two genome-wide association studies. (PubMed id 22446040)1, 4 Wang K.S....Callahan K. (Gene 2012)
    2. The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase. (PubMed id 19651899)1, 2 Zavacki A.M.... Bianco A.C. (Mol. Cell. Biol. 2009)
    3. Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI). (PubMed id 16373356)1, 2 Kreft S.G.... Hochstrasser M. (J. Biol. Chem. 2006)
    4. TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum. (PubMed id 15673284)1, 2 Hassink G.... Wiertz E. (Biochem. J. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PubMed id 14722266)1, 3 Bartee E.... Frueh K. (J. Virol. 2004)
    8. A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation. (PubMed id 11641273)1, 2 Swanson R.... Hochstrasser M. (Genes Dev. 2001)
    9. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (DNA Res. 1998)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10299 HGNC: 30550 AceView: MARCH-VI Ensembl:ENSG00000145495 euGenes: HUgn10299
    ECgene: MARCH6 Kegg: 10299 H-InvDB: MARCH6

    (According to HUGE)
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    HUGE: KIAA0597

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MARCH6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MARCH6 gene:
    Search GeneIP for patents involving MARCH6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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