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Aliases for MARCH6 Gene

Aliases for MARCH6 Gene

  • Membrane-Associated Ring Finger (C3HC4) 6, E3 Ubiquitin Protein Ligase 2 3
  • TEB4 3 4 6
  • Membrane-Associated RING Finger Protein 6 3 4
  • Membrane-Associated RING-CH Protein VI 3 4
  • RING Finger Protein 176 3 4
  • Doa10 Homolog 3 4
  • MARCH-VI 3 4
  • KIAA0597 4 6
  • RNF176 3 4
  • DOA10 3 6
  • Membrane-Associated RING-CH Finger Protein 6 3
  • Membrane-Associated Ring Finger (C3HC4) 6 2
  • E3 Ubiquitin-Protein Ligase MARCH6 3
  • Protein TEB-4 4
  • EC 6.3.2.- 4

External Ids for MARCH6 Gene

Summaries for MARCH6 Gene

Entrez Gene Summary for MARCH6 Gene

  • This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for MARCH6 Gene

MARCH6 (Membrane-Associated Ring Finger (C3HC4) 6, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin conjugating enzyme binding. An important paralog of this gene is MARCH2.

UniProtKB/Swiss-Prot for MARCH6 Gene

  • E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.

Gene Wiki entry for MARCH6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH6 Gene

Genomics for MARCH6 Gene

Genomic Location for MARCH6 Gene

10,353,639 bp from pter
10,440,388 bp from pter
86,750 bases
Plus strand

Genomic View for MARCH6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARCH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH6 Gene

Regulatory Elements for MARCH6 Gene

Proteins for MARCH6 Gene

  • Protein details for MARCH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase MARCH6
    Protein Accession:
    Secondary Accessions:
    • A5PKZ4
    • B4DKJ2
    • B4DT33
    • D3DTC8
    • O14670
    • Q86X77

    Protein attributes for MARCH6 Gene

    910 amino acids
    Molecular mass:
    102545 Da
    Quaternary structure:
    • Interacts with DIO2.
    • Sequence=AAB66840.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAB66840.1; Type=Frameshift; Positions=381, 382, 383, 385, 391, 396, 418; Evidence={ECO:0000305}; Sequence=BAA25523.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MARCH6 Gene


neXtProt entry for MARCH6 Gene

Proteomics data for MARCH6 Gene at MOPED

Post-translational modifications for MARCH6 Gene

  • Auto-ubiquitinated, which results in proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys20, Lys33, Lys45, Lys49, Lys56, Lys550, Lys881, Lys894, and Lys897

Other Protein References for MARCH6 Gene

No data available for DME Specific Peptides for MARCH6 Gene

Domains for MARCH6 Gene

Gene Families for MARCH6 Gene

  • RNF :RING-type (C3HC4) zinc fingers
  • MARCH :MARCH membrane-associated ring fingers

Protein Domains for MARCH6 Gene


  • The RING-CH-type zinc finger domain is required for E3 ligase activity:
    • O60337
  • Contains 1 RING-CH-type zinc finger.:
    • O60337
genes like me logo Genes that share domains with MARCH6: view

Function for MARCH6 Gene

Molecular function for MARCH6 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.

Enzyme Numbers (IUBMB) for MARCH6 Gene

Gene Ontology (GO) - Molecular Function for MARCH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IMP 19651899
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0019899 enzyme binding IPI 19651899
GO:0031624 ubiquitin conjugating enzyme binding IPI 15673284
genes like me logo Genes that share ontologies with MARCH6: view

miRNA for MARCH6 Gene

miRTarBase miRNAs that target MARCH6

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MARCH6 Gene

Localization for MARCH6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCH6 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MARCH6 Gene COMPARTMENTS Subcellular localization image for MARCH6 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for MARCH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0030176 integral component of endoplasmic reticulum membrane IDA 15673284
genes like me logo Genes that share ontologies with MARCH6: view

Pathways for MARCH6 Gene

genes like me logo Genes that share pathways with MARCH6: view

Pathways by source for MARCH6 Gene

1 KEGG pathway for MARCH6 Gene

UniProtKB/Swiss-Prot O60337-MARH6_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for MARCH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070936 protein K48-linked ubiquitination IDA 15673284
genes like me logo Genes that share ontologies with MARCH6: view

Compounds for MARCH6 Gene

(4) HMDB Compounds for MARCH6 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
Phosphoric acid
  • acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion
genes like me logo Genes that share compounds with MARCH6: view

Transcripts for MARCH6 Gene

Unigene Clusters for MARCH6 Gene

Membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
SP1: - - - -
SP4: -
SP6: - -

ExUns: 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
SP1: - -
SP5: -

Relevant External Links for MARCH6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MARCH6 Gene

mRNA expression in normal human tissues for MARCH6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MARCH6 Gene

SOURCE GeneReport for Unigene cluster for MARCH6 Gene Hs.432862

mRNA Expression by UniProt/SwissProt for MARCH6 Gene

Tissue specificity: Present in brain (at protein level).
genes like me logo Genes that share expressions with MARCH6: view

Orthologs for MARCH6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MARCH6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MARCH6 36
  • 99.89 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia MARCH6 36
  • 92.56 (n)
  • 98.35 (a)
  • 98 (a)
(Canis familiaris)
Mammalia MARCH6 36
  • 93.73 (n)
  • 98.46 (a)
  • 98 (a)
(Mus musculus)
Mammalia March6 36
  • 90.68 (n)
  • 98.33 (a)
March6 16
March6 37
  • 98 (a)
(Monodelphis domestica)
Mammalia MARCH6 37
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia MARCH6 37
  • 94 (a)
(Rattus norvegicus)
Mammalia March6 36
  • 90.31 (n)
  • 98.11 (a)
(Gallus gallus)
Aves MARCH6 36
  • 83.39 (n)
  • 94.2 (a)
  • 94 (a)
(Anolis carolinensis)
Reptilia MARCH6 37
  • 93 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14661 36
tropical clawed frog
(Silurana tropicalis)
Amphibia march6 36
  • 80.01 (n)
  • 90.97 (a)
Str.11781 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7694 36
(Danio rerio)
Actinopterygii Dr.26548 36
march6 36
  • 76.19 (n)
  • 90.18 (a)
march6 37
  • 89 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007204 36
  • 56.4 (n)
  • 58.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1317 36
  • 55.63 (n)
  • 53.45 (a)
CG1317 37
  • 47 (a)
(Caenorhabditis elegans)
Secernentea marc-6 36
  • 53.33 (n)
  • 44.14 (a)
marc-6 37
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSM4 37
  • 17 (a)
SSM4 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G34100 36
  • 46.05 (n)
  • 34.33 (a)
(Oryza sativa)
Liliopsida Os06g0639000 36
  • 45.14 (n)
  • 33.18 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2510 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
Species with no ortholog for MARCH6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARCH6 Gene

Gene Tree for MARCH6 (if available)
Gene Tree for MARCH6 (if available)

Paralogs for MARCH6 Gene

Paralogs for MARCH6 Gene

Selected SIMAP similar genes for MARCH6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MARCH6: view

Variants for MARCH6 Gene

Sequence variations from dbSNP and Humsavar for MARCH6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs7761 -- 10,435,238(+) CAACA(A/G)TTTTT utr-variant-3-prime
rs9544 -- 10,435,036(+) CGTAA(A/G)GGTAG utr-variant-3-prime
rs583314 -- 10,364,992(+) gagac(A/G)gggtt intron-variant
rs596376 -- 10,365,571(+) acagg(C/T)gtgag intron-variant
rs1045425 -- 10,411,498(+) GTTGG(C/T)TTTCA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MARCH6 Gene

Variant ID Type Subtype PubMed ID
nsv880520 CNV Gain 21882294
nsv880973 CNV Gain 21882294
nsv4713 CNV Loss 18451855
esv273891 CNV Insertion 20981092
esv271970 CNV Insertion 20981092

Relevant External Links for MARCH6 Gene

HapMap Linkage Disequilibrium report

Disorders for MARCH6 Gene

Relevant External Links for MARCH6

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with MARCH6: view

No data available for UniProtKB/Swiss-Prot for MARCH6 Gene

Publications for MARCH6 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  2. A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation. (PMID: 11641273) Swanson R. … Hochstrasser M. (Genes Dev. 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E. … Frueh K. (J. Virol. 2004) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MARCH6 Gene

Sources for MARCH6 Gene

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