Aliases for MARCH6 Gene
External Ids for MARCH6 Gene
This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for MARCH6 Gene
MARCH6 (Membrane-Associated Ring Finger (C3HC4) 6, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin conjugating enzyme binding. An important paralog of this gene is MARCH2.
UniProtKB/Swiss-Prot for MARCH6 Gene
E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.