Aliases for MARCH5 Gene
External Ids for MARCH5 Gene
Previous HGNC Symbols for MARCH5 Gene
Previous GeneCards Identifiers for MARCH5 Gene
MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008]
GeneCards Summary for MARCH5 Gene
MARCH5 (Membrane-Associated Ring Finger (C3HC4) 5) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity and GTPase binding.
UniProtKB/Swiss-Prot for MARCH5 Gene
Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.