Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MARCH5 Gene

protein-coding   GIFtS: 50
GCID: GC10P094041

Membrane-Associated Ring Finger (C3HC4) 5

(Previous name: ring finger protein 153)
(Previous symbol: RNF153)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Membrane-Associated Ring Finger (C3HC4) 51 2     MARCH-V2 3
RING Finger Protein 1531 2 3     MITOL2 3
RNF1531 2 3     E3 Ubiquitin-Protein Ligase MARCH52
Membrane-Associated RING Finger Protein 52 3     EC 6.3.2.-3
Membrane-Associated RING-CH Protein V2 3     EC 6.3.28
Mitochondrial Ubiquitin Ligase2 3     

External Ids:    HGNC: 260251   Entrez Gene: 547082   Ensembl: ENSG000001980607   OMIM: 6106375   UniProtKB: Q9NX473   

Export aliases for MARCH5 gene to outside databases

Previous GC identifer: GC10P087679


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MARCH5 Gene:
MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial
morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006
(PubMed 16936636)).(supplied by OMIM, Mar 2008)

GeneCards Summary for MARCH5 Gene:
MARCH5 (membrane-associated ring finger (C3HC4) 5) is a protein-coding gene. Diseases associated with MARCH5 include malaria, and neuronitis. GO annotations related to this gene include ubiquitin-protein ligase activity and GTPase binding.

UniProtKB/Swiss-Prot: MARH5_HUMAN, Q9NX47
Function: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial
morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell
senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and
MFN1

Gene Wiki entry for MARCH5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MARCH5 gene promoter:
         Pax-5   Nkx2-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   CUTL1   LCR-F1   HEN1   COMP1   NF-Y   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MARCH5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARCH5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.32-q23.33   Ensembl cytogenetic band:  10q23.32   HGNC cytogenetic band: 10q23.32-q23.33

MARCH5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCH5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P094041:  view genomic region     (about GC identifiers)

Start:
94,050,920 bp from pter      End:
94,113,721 bp from pter
Size:
62,802 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MARH5_HUMAN, Q9NX47 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MARCH5  
Size: 278 amino acids; 31232 Da
Subunit: Monomer and homodimer. Interacts with MFN1, MFN2, DNM1L and FIS1
Miscellaneous: By binding to and ubiquitinating two ALS1 variants of SOD1 (mSOD1 variants Arg-86 and Ala-94) it
attenuates their cytotoxicity

Explore the universe of human proteins at neXtProt for MARCH5: NX_Q9NX47

Explore proteomics data for MARCH5 at MOPED

Post-translational modifications: 

  • Autoubiquitinated leading to degradation (short half-life)1
  • Ubiquitination2 at Lys40
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MARCH5 (Q9NX47) (see all 8)
     CWVCFAT  KVYFKQQQYL  LGKMIRWEDYV  SNLQRTILGGIAFV 


    See MARCH5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060294.1  
    ENSEMBL proteins: 
     ENSP00000351813  

    MARCH5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MARCH5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MARCH5
    GenScript Custom Purified and Recombinant Proteins Services for MARCH5
    Novus Biologicals MARCH5 Proteins
    Novus Biologicals MARCH5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    MARCH5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MARCH5
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MARCH5
    OriGene Custom Antibody Services for MARCH5
    Novus Biologicals MARCH5 Antibodies
    Search for Antibodies for MARCH5 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for MARCH5
    Search LSBio for Antibodies for MARCH5

    MARCH5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MARCH5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MARCH5
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers
    MARCH: MARCH membrane-associated ring fingers

    2 InterPro protein domains:
     IPR013083 Znf_RING/FYVE/PHD
     IPR011016 Znf_RING-CH

    Graphical View of Domain Structure for InterPro Entry Q9NX47

    ProtoNet protein and cluster: Q9NX47

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB011016 RINGv


    UniProtKB/Swiss-Prot: MARH5_HUMAN, Q9NX47
    Domain: The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity)
    Similarity: Contains 1 RING-CH-type zinc finger


    MARCH5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARH5_HUMAN, Q9NX47
    Function: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial
    morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell
    senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and
    MFN1

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IMP16874301
    GO:0005515protein binding IPI16874301
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
    GO:0051020GTPase binding IPI16936636
         
    MARCH5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MARCH5:
     Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for March5):
     cellular  craniofacial  homeostasis/metabolism  immune system  mortality/aging 
     vision/eye 

    MARCH5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MARCH5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MARCH5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARCH5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARCH5

    miRNA
    Products:
        
    miRTarBase miRNAs that target MARCH5:
    hsa-mir-30a-5p (MIRT028466), hsa-let-7e-5p (MIRT051528)

    Block miRNA regulation of human, mouse, rat MARCH5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MARCH5 (see all 87):
    hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-128 hsa-miR-1245 hsa-miR-519a hsa-miR-520b hsa-miR-34c-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MARCH5
    Predesigned siRNA for gene silencing in human, mouse, rat MARCH5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MARCH5

    Clone
    Products:
         
    OriGene clones in human, mouse for MARCH5 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MARCH5
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MARCH5
    Browse ESI BIO Cell Lines and PureStem Progenitors for MARCH5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MARH5_HUMAN, Q9NX47: Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane.
    Note=Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266). Authors
    (PubMed:16874301) show its presence only in mitochondria (PubMed:16874301)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion5
    plasma membrane3
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005741mitochondrial outer membrane IDA16874301
    GO:0005783endoplasmic reticulum IDA14722266
    GO:0005789endoplasmic reticulum membrane IDA14722266
    GO:0016021integral component of membrane IEA--

    MARCH5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



    UniProtKB/Swiss-Prot: MARH5_HUMAN, Q9NX47
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MARCH5: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MARCH5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for MARCH5 (Q9NX471, 2, 3 ENSP000003518134) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FIS1Q9Y3D62, 3, ENSP000002231364MINT-2844143 I2D: score=2 STRING: ENSP00000223136
    DENRO435831, 2, 3, ENSP000002805574EBI-2341610,EBI-716083 MINT-3374425 MINT-2844192 I2D: score=1 STRING: ENSP00000280557
    UBCP0CG481, 2, 3, ENSP000003448184EBI-2341610,EBI-3390054 MINT-2844071 MINT-2844096 I2D: score=1 STRING: ENSP00000344818
    MFN2O951402, 3, ENSP000002353294MINT-3374405 I2D: score=2 STRING: ENSP00000235329
    AKTIPQ9H8T03, ENSP000003002454I2D: score=2 STRING: ENSP00000300245
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA16936636
    GO:0051865protein autoubiquitination IDA16874301
    GO:0070585protein localization to mitochondrion IMP17606867
    GO:0090140regulation of mitochondrial fission IMP16874301
    GO:0090141positive regulation of mitochondrial fission IMP--

    MARCH5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MARCH5 (MARH5)

    4 HMDB Compounds for MARCH5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MARCH5 gene: 
    NM_017824.4  

    Unigene Cluster for MARCH5:

    Membrane-associated ring finger (C3HC4) 5
    Hs.573490  [show with all ESTs]
    Unigene Representative Sequence: NM_017824
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358935(uc001khx.1 uc010qno.1) ENST00000467521 ENST00000462465
    ENST00000492319
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MARCH5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MARCH5 (see all 87):
    hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-128 hsa-miR-1245 hsa-miR-519a hsa-miR-520b hsa-miR-34c-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MARCH5
    Predesigned siRNA for gene silencing in human, mouse, rat MARCH5
    Clone
    Products:
         
    OriGene clones in human, mouse for MARCH5 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MARCH5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MARCH5
    OriGene qSTAR qPCR primer pairs in human, mouse for MARCH5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARCH5
      QuantiTect SYBR Green Assays in human, mouse, rat MARCH5
      QuantiFast Probe-based Assays in human, mouse, rat MARCH5

    Additional mRNA sequence: 

    AB191202.1 AK000452.1 AK294799.1 AK309175.1 BC015480.1 

    7 DOTS entries:

    DT.452787  DT.97809936  DT.95282577  DT.443541  DT.100786960  DT.91953905  DT.102825707 

    Selected AceView cDNA sequences (see all 203):

    Z38439 BM786638 BU625826 BM724976 AI243218 BQ576153 BU752083 AI435632 
    BQ216370 BM670158 BE673336 AA111896 BU902682 AA907364 AI803023 BX279973 
    BQ011598 AK000452 BM467256 BM545920 BM700148 AW028757 AA576671 CR622689 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MARCH5 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:              -     -     -                 -                                 
    SP2:                                            -                                 
    SP3:                    -     -                 -                                 
    SP4:              -           -                                                   
    SP5:              -     -     -                                                   


    ECgene alternative splicing isoforms for MARCH5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MARCH5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MARCH5 Expression
    About this image


    MARCH5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Thymus (Hematopoietic System)
    MARCH5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MARCH5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.573490

    UniProtKB/Swiss-Prot: MARH5_HUMAN, Q9NX47
    Tissue specificity: Expressed in brain, heart, liver, lung, spleen, stomach, testis, skeletal and muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MARCH5: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MARCH5
    OriGene qSTAR qPCR primer pairs in human, mouse for MARCH5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARCH5
    QuantiTect SYBR Green Assays in human, mouse, rat MARCH5
    QuantiFast Probe-based Assays in human, mouse, rat MARCH5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MARCH5 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia March51 , 5 membrane-associated ring finger (C3HC4) 51, 5 92.81(n)1
    100(a)1
      19 (32.20 cM)5
    691041  NM_027314.31  NP_081590.31 
     372075435 
    chicken
    (Gallus gallus)
    Aves MARCH51 membrane-associated ring finger (C3HC4) 5 87.23(n)
    98.18(a)
      423815  NM_001012906.1  NP_001012924.1 
    lizard
    (Anolis carolinensis)
    Reptilia MARCH56
    membrane-associated ring finger (C3HC4) 5
    97(a)
    1 ↔ 1
    GL343262.1(1835395-1885582)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.193452 Xenopus laevis transcribed sequence with strong similarity more 80.93(n)    BU899549.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC049066.12   -- 72.11(n)   326067  BC049066.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG98551 CG9855 55.64(n)
    54.89(a)
      40556  NM_141206.5  NP_649463.2 


    ENSEMBL Gene Tree for MARCH5 (if available)
    TreeFam Gene Tree for MARCH5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MARCH5 (see all 1042)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs585687821,2
    C--87740280(+) TGTGT-/GT/TA 
            
    ATTTG
    2 -- ut310--------
    rs344592301,2
    C--87742397(+) TAAAA-/GTAATCTG 1 -- int11Minor allele frequency- GTA:0.00NA 2
    rs1894317181,2
    --94052901(+) ATGCAA/GTGGCA 1 -- int10--------
    rs1424932771,2
    --94053036(+) TTTTGC/TATTTT 1 -- int10--------
    rs111868991,2
    C,F--94053124(+) CCAAAG/ATGCTG 1 -- int12Minor allele frequency- A:0.32NA EA 240
    rs1912148121,2
    --94053130(+) TGCTGG/TATTGT 1 -- int10--------
    rs1510155281,2
    C--94053287(+) CTTTGA/GGAGGC 1 -- int10--------
    rs610665781,2
    F--94053408(+) AGTGGC/TGTGGG 1 -- int11Minor allele frequency- T:0.10WA 118
    rs1422478481,2
    --94053584(+) AAATGC/TGAAGA 1 -- int10--------
    rs1460183651,2
    --94053771(+) GGGGAA/GCATTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for MARCH5 (94050920 - 94113721 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MARCH5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670111CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MARCH5
    DNA2.0 Custom Variant and Variant Library Synthesis for MARCH5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610637    OMIM disorders: --

    2 diseases for MARCH5:    
    About MalaCards
    malaria    neuronitis


    MARCH5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MARCH5

    Export disorders for MARCH5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MARCH5 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with MARCH5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PubMed id 14722266)1, 2, 3 Bartee E.... Frueh K. (J. Virol. 2004)
    2. Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1. (PubMed id 20103533)1, 2 Park Y.Y.... Cho H. (J. Cell Sci. 2010)
    3. Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation. (PubMed id 19741096)1, 2 Yonashiro R.... Yanagi S. (Mol. Biol. Cell 2009)
    4. The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division. (PubMed id 17606867)1, 2 Karbowski M.... Youle R.J. (J. Cell Biol. 2007)
    5. A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics. (PubMed id 16874301)1, 2 Yonashiro R....Yanagi S. (EMBO J. 2006)
    6. MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology. (PubMed id 16936636)1, 2 Nakamura N.... Hirose S. (EMBO Rep. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    10. MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2. (PubMed id 23727017)1 Sugiura A....Yanagi S. (Mol. Cell 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 54708 HGNC: 26025 AceView: RNF153 Ensembl:ENSG00000198060 euGenes: HUgn54708
    ECgene: MARCH5 H-InvDB: MARCH5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MARCH5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MARCH5 gene:
    Search GeneIP for patents involving MARCH5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of MARCH5
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MARCH5   OriGene RNAi products in human, mouse, rat for MARCH5  
     OriGene qPCR primer pairs and template standards for MARCH5   OriGene Protein Over-expression Lysate for MARCH5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MARCH5  
     OriGene qSTAR qPCR primer pairs in human, mouse for MARCH5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MARCH5   OriGene Custom Protein Services for MARCH5  

     
     
     Block miRNA regulation of human, mouse, rat MARCH5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MARCH5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARCH5 Predesigned siRNA for gene silencing in human, mouse, rat MARCH5
     QuantiFast Probe-based Assays in human, mouse, rat MARCH5 QuantiTect SYBR Green Assays in human, mouse, rat MARCH5
     PCR Arrays including human, mouse, rat MARCH5 Search Chromatin IP Primers for MARCH5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARCH5  GeneGlobe Interaction Network for MARCH5
     Regulatory tfbs in MARCH5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MARCH5 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for MARCH5
     GenScript Custom Assay Services for MARCH5 GenScript Custom overexpressing Cell Line Services for MARCH5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MARCH5 (MARH5)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MARCH5 antibodies
     MARCH5 proteins
     MARCH5 lysates
     Search for Antibodies for MARCH5 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MARCH5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for MARCH5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH5
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MARCH5
     Browse SwitchGear Promoter luciferase reporter plasmids for MARCH5
     ThermoFisher Antibody for MARCH5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MARCH5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MARCH5
     Search LSBio for Antibodies for MARCH5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MARCH5 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4