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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MARCH5 Gene

protein-coding   GIFtS: 46
GCID: GC10P094041

membrane-associated ring finger (C3HC4) 5

(Previous name: ring finger protein 153 )
(Previous symbol: RNF153)
  Search for MARCH5
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MARCH5    

Aliases
for MARCH5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Membrane-Associated Ring Finger (C3HC4) 51 2     Mitochondrial Ubiquitin Ligase2 3
RING Finger Protein 1531 2 3     MITOL2 3
MARCH-V1 2 3     FLJ204451
RNF1531 2 3     E3 Ubiquitin-Protein Ligase MARCH52
Membrane-Associated RING Finger Protein 52 3     EC 6.3.2.-3
Membrane-Associated RING-CH Protein V2 3     EC 6.3.28

External Ids:    HGNC: 260251   Entrez Gene: 547082   Ensembl: ENSG000001980607   OMIM: 6106375   UniProtKB: Q9NX473   

Export aliases for MARCH5 gene to outside databases

Previous GC identifer: GC10P087679


Summaries
for MARCH5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MARCH5:
MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial
morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 (PubMed
16936636)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: MARH5_HUMAN, Q9NX47
Function: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial
morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell
senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1

Gene Wiki entry for MARCH5


Genomic Views
for MARCH5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MARCH5 gene promoter:
         Pax-5   Nkx2-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   CUTL1   LCR-F1   HEN1   COMP1   NF-Y   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MARCH5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARCH5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.32-q23.33   Ensembl cytogenetic band:  10q23.32   HGNC cytogenetic band: 10q23.32-q23.33

MARCH5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCH5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P094041:  view genomic region     (about GC identifiers)

Start:
 94,050,920 bp from pter      End:
 94,113,721 bp from pter
Size:
 62,802 bases      Orientation:
 plus strand

Proteins
for MARCH5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MARH5_HUMAN, Q9NX47 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MARCH5  
Size: 278 amino acids; 31232 Da
Subunit: Monomer and homodimer. Interacts with MFN1, MFN2, DNM1L and FIS1
Subcellular location: Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane.
Note=Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266). Authors
(PubMed:16874301) show its presence only in mitochondria (PubMed:16874301)
Miscellaneous: By binding to and ubiquitinating two ALS1 variants of SOD1 (mSOD1 variants Arg-86 and Ala-94) it
attenuates their cytotoxicity

Explore the universe of human proteins at neXtProt for MARCH5: NX_Q9NX47

Post-translational modifications:

  • Autoubiquitinated leading to degradation (short half-life)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NX47

    • 4/8 DME Specific Peptides for MARCH5 (Q9NX47) (see all 8)
     CWVCFAT  KVYFKQQQYL  LGKMIRWEDYV  SNLQRTILGGIAFV 

    MARCH5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060294.1  
    ENSEMBL proteins: 
     ENSP00000351813  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals MARCH5 Proteins
    Novus Biologicals MARCH5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005741mitochondrial outer membrane IDA16874301
    GO:0005783endoplasmic reticulum IDA14722266
    GO:0005789endoplasmic reticulum membrane IDA14722266
    GO:0016021integral to membrane IEA--


    MARCH5 for ontologies           About GeneDecksing



    MARCH5 Antibody Products: 
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    ThermoFisher Antibody for MARCH5

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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for MARCH5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MARCH5 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR013083 Znf_RING/FYVE/PHD
     IPR011016 Znf_RING-CH

    Graphical View of Domain Structure for InterPro Entry Q9NX47

    ProtoNet protein and cluster: Q9NX47

    2 Blocks protein families:
    IPB001841 Zn-finger
    IPB011016 RINGv


    UniProtKB/Swiss-Prot: MARH5_HUMAN, Q9NX47
    Domain: The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity)
    Similarity: Contains 1 RING-CH-type zinc finger


    Function
    for MARCH5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MARH5_HUMAN, Q9NX47
    Function: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial
    morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell
    senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1

    Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARCH5
    8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate MARCH5 (see all 87):
    hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-128 hsa-miR-1245 hsa-miR-519a hsa-miR-520b hsa-miR-34c-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: MARCH5
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MARCH5

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH5 

    Cell Line
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    Search LifeMap BioReagents cell lines for MARCH5

    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IMP16874301
    GO:0005515protein binding IPI16874301
    GO:0008270zinc ion binding IEA--
    GO:0051020GTPase binding IPI16936636


    MARCH5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MARCH5:
     Synthetic lethal with Ras 

    Animal Models:
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for March5):
     craniofacial  homeostasis/metabolism  immune system  mortality/aging  vision/eye 

    MARCH5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MARCH5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: MARH5_HUMAN, Q9NX47
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MARCH5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/19 Interacting proteins for MARCH5 (Q9NX472, 3 ENSP000003518134) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    FIS1Q9Y3D62, 3, ENSP000002231364MINT-2844143 I2D: score=2 STRING: ENSP00000223136
    DENRO435832, 3, ENSP000002805574MINT-3374425 MINT-2844192 I2D: score=1 STRING: ENSP00000280557
    UBCP0CG482, 3, ENSP000003448184MINT-2844071 MINT-2844096 I2D: score=1 STRING: ENSP00000344818
    MFN2O951402, 3, ENSP000002353294MINT-3374405 I2D: score=2 STRING: ENSP00000235329
    AKTIPQ9H8T03, ENSP000003002454I2D: score=2 STRING: ENSP00000300245
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA16936636
    GO:0016567protein ubiquitination ----
    GO:0051865protein autoubiquitination IDA16874301
    GO:0070585protein localization to mitochondrion IMP17606867
    GO:0090140regulation of mitochondrial fission IMP16874301


    MARCH5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MARCH5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MARCH5

    4 HMDB Compounds for MARCH5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about MARCH5 / MARH5 

    Transcripts
    for MARCH5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MARCH5 gene: 
    NM_017824.4  

    Unigene Cluster for MARCH5:

    Membrane-associated ring finger (C3HC4) 5
    Hs.573490  [show with all ESTs]
    Unigene Representative Sequence: NM_017824
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358935(uc001khx.1 uc010qno.1) ENST00000467521 ENST00000462465
    ENST00000492319

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARCH5
    8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate MARCH5 (see all 87):
    hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-128 hsa-miR-1245 hsa-miR-519a hsa-miR-520b hsa-miR-34c-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MARCH5
    OriGene shRNA RFP: MARCH5
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARCH5
    Clone
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MARCH5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARCH5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARCH5

    Additional cDNA sequence: 

    AB191202.1 AK000452.1 AK294799.1 AK309175.1 BC015480.1 

    7 DOTS entries:

    DT.452787  DT.97809936  DT.95282577  DT.443541  DT.100786960  DT.91953905  DT.102825707 

    24/203 AceView cDNA sequences (see all 203):

    BQ959939 CB131639 BM700148 AW298533 AW028757 AI587653 AA576671 BM545920 
    CR618394 BI830234 CR616758 BU902682 BQ576153 AA370838 BQ216370 BX279973 
    AI243218 BF197837 N68098 AA111896 AW015612 CR622689 BM467256 CA842415 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MARCH5 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:              -     -     -                 -                                 
    SP2:                                            -                                 
    SP3:                    -     -                 -                                 
    SP4:              -           -                                                   
    SP5:              -     -     -                                                   


    ECgene alternative splicing isoforms for MARCH5

    Expression
    for MARCH5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MARCH5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MARCH5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MARCH5

    SOURCE GeneReport for Unigene cluster: Hs.573490

    UniProtKB/Swiss-Prot: MARH5_HUMAN, Q9NX47
    Tissue specificity: Expressed in brain, heart, liver, lung, spleen, stomach, testis, skeletal and muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including MARCH5: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH5

    Orthologs
    for MARCH5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MARCH5 gene from 7/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia March51 , 5 membrane-associated ring finger (C3HC4) 51, 5 92.81(n)1
    100(a)1    		   19 (32.20 cM)5
    691041  NM_027314.31  NP_081590.31 
     372075435 
    chicken
    (Gallus gallus)    		 Aves MARCH51 membrane-associated ring finger (C3HC4) 5 87.23(n)
    98.18(a)    		   423815  NM_001012906.1  NP_001012924.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MARCH56
    --
    		 --
    		 97(a)
    69(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343262.1(1835395-1850752)
    GL343484.1(116456-119378)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.193452 Xenopus laevis transcribed sequence with strong similarity more 80.93(n)    BU899549.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC049066.12   -- 72.11(n)   326067  BC049066.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG98551 CG9855 55.6(n)
    55.09(a)    		   40556  NM_141206.4  NP_649463.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea M110.36
    		 Protein M110.3
    		 26(a)
    		 1 ↔ 1
    		 II(8214525-8216501)


    ENSEMBL Gene Tree for MARCH5 (if available)
    TreeFam Gene Tree for MARCH5 (if available) 

    Paralogs
    for MARCH5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for MARCH5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/892 NCBI SNPs in MARCH5 are shown (see all 892)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1894317181,2
    		--94052901(+) ATGCAA/GTGGCA 1 -- int10--------
    rs1424932771,2
    		--94053036(+) TTTTGC/TATTTT 1 -- int10--------
    rs111868991,2
    		C,F,--94053124(+) CCAAAG/ATGCTG 1 -- int12Minor allele frequency- A:0.32NA EA 240
    rs1912148121,2
    		--94053130(+) TGCTGG/TATTGT 1 -- int10--------
    rs1510155281,2
    		--94053287(+) CTTTGA/GGAGGC 1 -- int10--------
    rs610665781,2
    		F,--94053408(+) AGTGGC/TGTGGG 1 -- int11Minor allele frequency- T:0.10WA 118
    rs1422478481,2
    		--94053584(+) AAATGC/TGAAGA 1 -- int10--------
    rs1460183651,2
    		--94053771(+) GGGGAA/GCATTT 1 -- int10--------
    rs1478216691,2
    		--94053777(+) CATTTC/TAGAAT 1 -- int10--------
    rs1837018991,2
    		--94053997(+) ATTTTG/TCCACT 1 -- int10--------

    HapMap Linkage Disequilibrium report for MARCH5 (94050920 - 94113721 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MARCH5: --

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    Disorders / Diseases
    for MARCH5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MARCH5 for disorders           About MalaCards

    MARCH5 for disorders           About GeneDecksing

    OMIM gene information: 610637    OMIM disorders: --


    Export disorders for MARCH5 gene to outside databases

    Publications
    for MARCH5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MARCH5 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with MARCH5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PubMed id 14722266)1, 2, 3 Bartee E.... Frueh K. (2004)
    2. Loss of MARCH5 mitochondrial E3 ubiquitin ligase indu ces cellular senescence through dynamin-related protein 1 and mitofusin 1. (PubMed id 20103533)1, 2 Park Y.Y....Cho H. (2010)
    3. Mitochondrial ubiquitin ligase MITOL ubiquitinates mu tant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation . (PubMed id 19741096)1, 2 Yonashiro R....Yanagi S. (2009)
    4. The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division. (PubMed id 17606867)1, 2 Karbowski M....Youle R.J. (2007)
    5. A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics. (PubMed id 16874301)1, 2 Yonashiro R....Yanagi S. (2006)
    6. MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology. (PubMed id 16936636)1, 2 Nakamura N.... Hirose S. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    10. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)

    External Searches for MARCH5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MARCH5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54708 HGNC: 26025 AceView: RNF153 Ensembl:ENSG00000198060 euGenes: HUgn54708
    ECgene: MARCH5 H-InvDB: MARCH5

    Other Databases showing MARCH5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MARCH5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MARCH5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MARCH5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MARCH5 gene:
    Search GeneIP for patents involving MARCH5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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