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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MARCH4 Gene

protein-coding   GIFtS: 48
GCID: GC02M217122

membrane-associated ring finger (C3HC4) 4, E3 ubiquitin...

(Previous name: membrane-associated ring finger (C3HC4) 4 )
  Search for MARCH4
in
MalaCards
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 Human Malady Compendium 
Biological research products
for MARCH4    

Aliases
for MARCH4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Membrane-Associated Ring Finger (C3HC4) 4, E3 Ubiquitin Protein Ligase1 2     Membrane-Associated RING-CH Protein IV2 3
RNF1741 2 3 5     RING Finger Protein 1742 3
MARCH-IV1 2 3     Membrane-Associated Ring Finger (C3HC4) 41
KIAA13991 3 5     E3 Ubiquitin-Protein Ligase MARCH42
Membrane-Associated RING Finger Protein 42 3     EC 6.3.2.-3

External Ids:    HGNC: 292691   Entrez Gene: 575742   Ensembl: ENSG000001445837   OMIM: 6082085   UniProtKB: Q9P2E83   

Export aliases for MARCH4 gene to outside databases

Previous GC identifers: GC02M216949 GC02M216830 GC02M208976


Summaries
for MARCH4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MARCH4:
MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add
ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport
between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them
to the endosomal compartment (Bartee et al., 2004 (PubMed 14722266)).(supplied by OMIM, Apr 2010)

UniProtKB/Swiss-Prot: MARH4_HUMAN, Q9P2E8
Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent
endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2
ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted
substrates




Genomic Views
for MARCH4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MARCH4 gene promoter:
         HOXA9B   HOXA9   Nkx3-1   Nkx3-1 v4   RREB-1   Nkx3-1 v1   C/EBPalpha   Nkx3-1 v2   SRY   Nkx3-1 v3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MARCH4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARCH4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

MARCH4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCH4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M217122:  view genomic region     (about GC identifiers)

Start:
 217,122,585 bp from pter      End:
 217,236,750 bp from pter
Size:
 114,166 bases      Orientation:
 minus strand

Proteins
for MARCH4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MARH4_HUMAN, Q9P2E8 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MARCH4 precursor  
Size: 410 amino acids; 45528 Da
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAA92637.1; Type=Erroneous initiation;
Secondary accessions: Q4KMN7 Q86WR8

Explore the universe of human proteins at neXtProt for MARCH4: NX_Q9P2E8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P2E8

    • MARCH4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065865.1  
    ENSEMBL proteins: 
     ENSP00000273067  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: MARCH4
    OriGene Custom Protein Services for MARCH4 
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    Novus Biologicals MARCH4 Protein
    Novus Biologicals MARCH4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005795Golgi stack IDA14722266
    GO:0005802trans-Golgi network IDA14722266
    GO:0016021integral to membrane IEA--


    MARCH4 for ontologies           About GeneDecksing



    MARCH4 Antibody Products: 
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    ThermoFisher Antibodies for MARCH4

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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for MARCH4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MARCH4 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR013083 Znf_RING/FYVE/PHD
     IPR011016 Znf_RING-CH

    Graphical View of Domain Structure for InterPro Entry Q9P2E8

    ProtoNet protein and cluster: Q9P2E8

    2 Blocks protein families:
    IPB001841 Zn-finger
    IPB011016 RINGv


    UniProtKB/Swiss-Prot: MARH4_HUMAN, Q9P2E8
    Domain: The RING-CH-type zinc finger domain is required for E3 ligase activity
    Similarity: Contains 1 RING-CH-type zinc finger


    Function
    for MARCH4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MARH4_HUMAN, Q9P2E8
    Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent
    endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2
    ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted
    substrates

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
    Products:            		miRTarBase miRNAs that target MARCH4:
    hsa-mir-373 (MIRT004073)

    OriGene 3'-UTR Clone: MARCH4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARCH4
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate MARCH4 (see all 48):
    hsa-miR-3607-3p hsa-miR-106a hsa-miR-548k hsa-miR-15a hsa-miR-25 hsa-miR-30d hsa-miR-218 hsa-miR-374c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MARCH4
    OriGene shRNA RFP: MARCH4
    OriGene siRNA: MARCH4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARCH4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MARCH4

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MARCH4
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MARCH4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript Custom all cDNA clones Services for MARCH4
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MARCH4
    Search LifeMap BioReagents cell lines for MARCH4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH4

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA14722266
    GO:0008270zinc ion binding IEA--


    MARCH4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MARCH4:
     Increased circadian period len 


    Pathways & Interactions
    for MARCH4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: MARH4_HUMAN, Q9P2E8
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MARCH4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for MARCH4 (Q9P2E83 ENSP000002730674) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD4P017303, ENSP000000116534I2D: score=1 STRING: ENSP00000011653
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination ----


    MARCH4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MARCH4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MARCH4

    4 HMDB Compounds for MARCH4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about MARCH4 / MARH4 

    Transcripts
    for MARCH4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MARCH4 gene: 
    NM_020814.2  

    Unigene Cluster for MARCH4:

    Membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
    Hs.170388  [show with all ESTs]
    Unigene Representative Sequence: NM_020814
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000273067(uc002vgb.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARCH4
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate MARCH4 (see all 48):
    hsa-miR-3607-3p hsa-miR-106a hsa-miR-548k hsa-miR-15a hsa-miR-25 hsa-miR-30d hsa-miR-218 hsa-miR-374c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MARCH4
    OriGene shRNA RFP: MARCH4
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARCH4
    Clone
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MARCH4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARCH4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARCH4

    Additional cDNA sequence: 

    AB037820.1 AL353945.1 BC048793.1 BC098448.1 U79281.1 

    1 DOTS entry:

    DT.311588 

    24/40 AceView cDNA sequences (see all 40):

    AA872140 D81270 AA932963 AA989244 F10895 AA829736 BC048793 AI084800 
    AA878741 D81241 AB037820 BX283349 BV195150 U79281 AA349815 BM554507 
    F13295 BM561212 BM810875 AA349816 AA976832 BV195149 CO248049 AA927558 

    GeneLoc Exon Structure


    Expression
    for MARCH4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MARCH4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGTATTAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MARCH4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerType1 Off Cone Bipolar CellsBipolar, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    Line H7 (WA07) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See MARCH4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MARCH4

    SOURCE GeneReport for Unigene cluster: Hs.170388

    UniProtKB/Swiss-Prot: MARH4_HUMAN, Q9P2E8
    Tissue specificity: Expressed in brain and placenta

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH4

    Orthologs
    for MARCH4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MARCH4 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves Mar-041 membrane-associated ring finger (C3HC4) 4 79.31(n)
    84.97(a)    		   424221  XM_422071.3  XP_422071.3 
    lizard
    (Anolis carolinensis)    		 Reptilia MARCH46
    		 --
    		 80(a)
    		 1 ↔ 1
    		 GL343344.1(1047541-1074824)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.184802 Transcribed sequence 81.51(n)    BQ284523.1 


    ENSEMBL Gene Tree for MARCH4 (if available)
    TreeFam Gene Tree for MARCH4 (if available) 

    Paralogs
    for MARCH4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MARCH4 gene
    MARCH82  MARCH32  MARCH112  MARCH12  MARCH22  MARCH92  
    2 SIMAP similar genes for MARCH4 using alignment to 1 protein entry:     MARH4_HUMAN:
    MARCH9    MARCH11

    MARCH4 for paralogs           About GeneDecksing



    Genomic Variants
    for MARCH4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2005 NCBI SNPs in MARCH4 are shown (see all 2005)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1499992511,2
    		--217122179(+) AACACC/TCCTCT 1 -- int10--------
    rs2000674361,2
    		--217122187(+) TCTCC-/TGTGTGT 1 -- int10--------
    rs1472737931,2
    		--217122216(+) TGAAAC/TGACCA 1 -- int10--------
    rs1852933871,2
    		--217122229(+) TGAAGC/TGGAGC 1 -- int10--------
    rs1404780261,2
    		--217122260(+) CCCATA/GGTCTC 1 -- int10--------
    rs1444296511,2
    		--217122299(+) TGGGAC/GAGCCT 1 -- int10--------
    rs2063741,2
    		C,F,A,H,--217122402(-) GCAGGG/ATAGGC 1 -- int122Minor allele frequency- A:0.41NS EA NA WA CSA 2350
    rs2078681,2
    		C,F,A,H,--217122410(-) CGGACG/AGGGCA 1 -- int124Minor allele frequency- A:0.23NS EA NA WA CSA 2342
    rs1905964301,2
    		--217122513(+) AGGGAG/TAAAGA 1 -- int10--------
    rs1478337731,2
    		--217122588(+) ACTAAC/TGGTAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MARCH4 (217122585 - 217236750 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MARCH4
         1 Indel: 40418

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MARCH4
    DNA2.0 Custom Variant and Variant Library Synthesis for MARCH4

    Disorders / Diseases
    for MARCH4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MARCH4 for disorders           About MalaCards

    MARCH4 for disorders           About GeneDecksing

    OMIM gene information: 608208    OMIM disorders: --


    Export disorders for MARCH4 gene to outside databases

    Publications
    for MARCH4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MARCH4 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MARCH4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PubMed id 14722266)1, 2, 3, 9 Bartee E.... Frueh K. (2004)
    2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Genome-wide association analysis identifies susceptibi lity loci for migraine without aura. (PubMed id 22683712)1 Freilinger T....van den Maagdenberg A.M. (2012)
    5. Membrane-Associated RING-CH proteins associate with B ap31 and target CD81 and CD44 to lysosomes. (PubMed id 21151997)1 Bartee E....FrA1h K. (2010)
    6. Stress-regulated targeting of the NKG2D ligand Mult1 by a membrane-associated RING-CH family E3 ligase. (PubMed id 20870941)1 Nice T.J....Raulet D.H. (2010)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
    9. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (1996)

    External Searches for MARCH4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
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    Genome Databases showing MARCH4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57574 HGNC: 29269 AceView: MARCH-IV Ensembl:ENSG00000144583 euGenes: HUgn57574
    ECgene: MARCH4 H-InvDB: MARCH4

    Other Databases showing MARCH4 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1399

    Specialized Databases showing MARCH4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MARCH4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MARCH4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MARCH4 gene:
    Search GeneIP for patents involving MARCH4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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