Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MARCH4 Gene

protein-coding   GIFtS: 49
GCID: GC02M217122

Membrane-Associated Ring Finger (C3HC4) 4, E3 Ubiquitin...

(Previous name: membrane-associated ring finger (C3HC4) 4)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Membrane-Associated Ring Finger (C3HC4) 4, E3 Ubiquitin Protein
Ligase1 2
     RING Finger Protein 1742 3
RNF1742 3 5     KIAA13993 5
Membrane-Associated RING Finger Protein 42 3     Membrane-Associated Ring Finger (C3HC4) 41
Membrane-Associated RING-CH Protein IV2 3     E3 Ubiquitin-Protein Ligase MARCH42
MARCH-IV2 3     EC 6.3.2.-3

External Ids:    HGNC: 292691   Entrez Gene: 575742   Ensembl: ENSG000001445837   OMIM: 6082085   UniProtKB: Q9P2E83   

Export aliases for MARCH4 gene to outside databases

Previous GC identifers: GC02M216949 GC02M216830 GC02M208976


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MARCH4 Gene:
MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add
ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport
between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing
them to the endosomal compartment (Bartee et al., 2004 (PubMed 14722266)).(supplied by OMIM, Apr 2010)

GeneCards Summary for MARCH4 Gene: 
MARCH4 (membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with MARCH4 include migraine without aura, and migraine. GO annotations related to this gene include ubiquitin-protein ligase activity and zinc ion binding. An important paralog of this gene is MARCH11.

UniProtKB/Swiss-Prot: MARH4_HUMAN, Q9P2E8
Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their
subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin
from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to
targeted substrates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MARCH4 gene promoter:
         HOXA9B   HOXA9   Nkx3-1   Nkx3-1 v4   RREB-1   Nkx3-1 v1   C/EBPalpha   Nkx3-1 v2   SRY   Nkx3-1 v3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MARCH4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARCH4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

MARCH4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCH4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M217122:  view genomic region     (about GC identifiers)

Start:
217,122,585 bp from pter      End:
217,236,750 bp from pter
Size:
114,166 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MARH4_HUMAN, Q9P2E8 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MARCH4 precursor  
Size: 410 amino acids; 45528 Da
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAA92637.1; Type=Erroneous initiation;
Secondary accessions: Q4KMN7 Q86WR8

Explore the universe of human proteins at neXtProt for MARCH4: NX_Q9P2E8

Explore proteomics data for MARCH4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P2E8

  • MARCH4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MARCH4 Protein Expression
    REFSEQ proteins: NP_065865.1  
    ENSEMBL proteins: 
     ENSP00000273067  

    Human Recombinant Protein Products for MARCH4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MARCH4
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MARCH4
    GenScript Custom Purified and Recombinant Proteins Services for MARCH4
    Novus Biologicals MARCH4 Protein
    Novus Biologicals MARCH4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005795Golgi stack IDA14722266
    GO:0005802trans-Golgi network IDA14722266
    GO:0016021integral to membrane IEA--

    MARCH4 for ontologies           About GeneDecksing



    MARCH4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MARCH4
    GenScript Custom Superior Antibodies Services for MARCH4
    Novus Biologicals MARCH4 Antibodies
    Abcam antibodies for MARCH4
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for MARCH4
    LSBio Antibodies in human, mouse, rat for MARCH4 

    Assay Products for MARCH4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MARCH4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MARCH4
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers
    MARCH: MARCH membrane-associated ring fingers

    2 InterPro protein domains:
     IPR013083 Znf_RING/FYVE/PHD
     IPR011016 Znf_RING-CH

    Graphical View of Domain Structure for InterPro Entry Q9P2E8

    ProtoNet protein and cluster: Q9P2E8

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB011016 RINGv


    UniProtKB/Swiss-Prot: MARH4_HUMAN, Q9P2E8
    Domain: The RING-CH-type zinc finger domain is required for E3 ligase activity
    Similarity: Contains 1 RING-CH-type zinc finger


    MARCH4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARH4_HUMAN, Q9P2E8
    Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their
    subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin
    from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to
    targeted substrates

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA14722266
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    MARCH4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MARCH4:
     Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MARCH4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MARCH4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARCH4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARCH4 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MARCH4:
    hsa-mir-373 (MIRT004073)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARCH4
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate MARCH4 (see all 48):
    hsa-miR-3607-3p hsa-miR-106a hsa-miR-548k hsa-miR-15a hsa-miR-25 hsa-miR-30d hsa-miR-218 hsa-miR-374c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MARCH4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARCH4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MARCH4
    Sirion Biotech Customized adenovirus for overexpression of MARCH4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MARCH4 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MARCH4
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH4
    Sirion Biotech Customized lentivirus for stable overexpression of MARCH4 
                         Customized lentivirus expression plasmids for stable overexpression of MARCH4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MARCH4
    Search LifeMap BioReagents cell lines for MARCH4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: MARH4_HUMAN, Q9P2E8
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MARCH4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for MARCH4 (Q9P2E83 ENSP000002730674) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD4P017303, ENSP000000116534I2D: score=1 STRING: ENSP00000011653
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MARCH4 (MARH4)

    4 HMDB Compounds for MARCH4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about MARCH4 / MARH4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MARCH4 gene: 
    NM_020814.2  

    Unigene Cluster for MARCH4:

    Membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
    Hs.170388  [show with all ESTs]
    Unigene Representative Sequence: NM_020814
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000273067(uc002vgb.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARCH4
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate MARCH4 (see all 48):
    hsa-miR-3607-3p hsa-miR-106a hsa-miR-548k hsa-miR-15a hsa-miR-25 hsa-miR-30d hsa-miR-218 hsa-miR-374c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MARCH4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARCH4
    Clone
    Products:
         
    OriGene clones in human, mouse for MARCH4 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MARCH4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH4
    Sirion Biotech Customized lentivirus for stable overexpression of MARCH4 
                         Customized lentivirus expression plasmids for stable overexpression of MARCH4 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MARCH4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MARCH4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARCH4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARCH4

    Additional mRNA sequence: 

    AB037820.1 AL353945.1 BC048793.1 BC098448.1 U79281.1 

    1 DOTS entry:

    DT.311588 

    24/40 AceView cDNA sequences (see all 40):

    AA878741 AA932963 D81270 BC048793 AA829736 F10895 AA872140 AI084800 
    AA989244 D81241 BM558985 BM554507 AB037820 AA349816 CA446657 AA349815 
    AL353945 U79281 BX283349 AI372509 BM561209 BM916670 BV195150 AW954545 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MARCH4 expression in normal human tissues (normalized intensities)      MARCH4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTATTAAAA
    MARCH4 Expression
    About this image


    MARCH4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 22 entries
             Thalamus
             Human Hippocampal Astrocytes   
             Substantia Nigra   
     
     Fibroblast
             X-gene Foreskin Fibroblasts   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Dermis (Uncategorized)    fully expand to see all 2 entries
             BH2 Dermal Fibroblasts   
     
     Smooth Muscle (Extraembryonic Tissues)
             Human umbilical Smooth Muscle (HUSM)   

    See MARCH4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MARCH4

    SOURCE GeneReport for Unigene cluster: Hs.170388

    UniProtKB/Swiss-Prot: MARH4_HUMAN, Q9P2E8
    Tissue specificity: Expressed in brain and placenta

        SABiosciences Custom PCR Arrays for MARCH4
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MARCH4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MARCH4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARCH4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARCH4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MARCH4 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia March41 , 5 membrane-associated ring finger (C3HC4) 41, 5 88.81(n)1
    90.44(a)1
      1 (36.54 cM)5
    3812701  NM_001045533.11  NP_001038998.11 
     724271125 
    chicken
    (Gallus gallus)
    Aves Mar-041 membrane-associated ring finger (C3HC4) 4 79.31(n)
    84.97(a)
      424221  XM_422071.3  XP_422071.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    MARCH46
    Uncharacterized protein
    81(a)
    58(a)
    possible ortholog
    1 ↔ 1
    GL343344.1(1047541-1074824)
    2(66821412-66821768)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.184802 Transcribed sequence 81.51(n)    BQ284523.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F58E6.126
    Protein F58E6.12
    17(a)
    1 → many
    V(9739666-9740870)


    ENSEMBL Gene Tree for MARCH4 (if available)
    TreeFam Gene Tree for MARCH4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MARCH4 gene
    MARCH112  MARCH92  
    2 SIMAP similar genes for MARCH4 using alignment to 1 protein entry:     MARH4_HUMAN:
    MARCH9    MARCH11

    MARCH4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2307 SNPs in MARCH4 are shown (see all 2307)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1499992511,2
    --217122179(+) AACACC/TCCTCT 1 -- int10--------
    rs58385751,2
    C--217122187(+) GTGTG-/TGGCTTT 1 -- int10--------
    rs1472737931,2
    --217122216(+) TGAAAC/TGACCA 1 -- int10--------
    rs1852933871,2
    --217122229(+) TGAAGC/TGGAGC 1 -- int10--------
    rs1404780261,2
    --217122260(+) CCCATA/GGTCTC 1 -- int10--------
    rs1444296511,2
    --217122299(+) TGGGAC/GAGCCT 1 -- int10--------
    rs2063741,2
    C,F,A,H--217122402(-) GCAGGG/ATAGGC 1 -- int122Minor allele frequency- A:0.41NS EA NA WA CSA 2350
    rs2078681,2
    C,F,A,H--217122410(-) CGGACG/AGGGCA 1 -- int124Minor allele frequency- A:0.23NS EA NA WA CSA 2342
    rs1905964301,2
    --217122513(+) AGGGAG/TAAAGA 1 -- int10--------
    rs1478337731,2
    --217122588(+) ACTAAC/TGGTAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MARCH4 (217122585 - 217236750 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for MARCH4 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2721458CNV Deletion23290073
    esv2721460CNV Deletion23290073
    dgv673e201CNV Deletion23290073
    esv1006636CNV Deletion20482838
    esv2678065CNV Deletion23128226
    nsv507067CNV Insertion20534489
    nsv3160CNV Loss18451855
    nsv834537CNV Loss17160897
    nsv875845CNV Gain21882294
    nsv875843CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MARCH4
    DNA2.0 Custom Variant and Variant Library Synthesis for MARCH4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608208    OMIM disorders: --

    2 diseases for MARCH4:    About MalaCards
    migraine without aura    migraine


    MARCH4 for disorders           About GeneDecksing


    Export disorders for MARCH4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MARCH4 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MARCH4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PubMed id 14722266)1, 2, 3, 9 Bartee E.... Frueh K. (2004)
    2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Genome-wide association analysis identifies susceptibi lity loci for migraine without aura. (PubMed id 22683712)1 Freilinger T....van den Maagdenberg A.M. (2012)
    5. Membrane-Associated RING-CH proteins associate with B ap31 and target CD81 and CD44 to lysosomes. (PubMed id 21151997)1 Bartee E....FrA1h K. (2010)
    6. Stress-regulated targeting of the NKG2D ligand Mult1 by a membrane-associated RING-CH family E3 ligase. (PubMed id 20870941)1 Nice T.J....Raulet D.H. (2010)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
    9. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57574 HGNC: 29269 AceView: MARCH-IV Ensembl:ENSG00000144583 euGenes: HUgn57574
    ECgene: MARCH4 H-InvDB: MARCH4

    (According to HUGE)
    About This Section
    HUGE: KIAA1399

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MARCH4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MARCH4 gene:
    Search GeneIP for patents involving MARCH4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MARCH4  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for MARCH4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MARCH4  
     OriGene qSTAR qPCR primer pairs in human, mouse for MARCH4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MARCH4   OriGene Custom Protein Services for MARCH4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MARCH4
     QIAGEN SeqTarget long-range PCR primers for resequencing MARCH4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARCH4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARCH4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARCH4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARCH4
     GenScript Custom Purified and Recombinant Proteins Services for MARCH4 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for MARCH4
     GenScript Custom Assay Services for MARCH4 GenScript Custom Superior Antibodies Services for MARCH4
     GenScript Custom overexpressing Cell Line Services for MARCH4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MARCH4 promoter
     Search Chromatin IP Primers for MARCH4
     RT2 qPCR Primer Assay in human, mouse, rat MARCH4
     Search GNC Networks for MARCH4
     SABiosciences Custom PCR Arrays for MARCH4
     Search Tocris compounds for MARCH4 (MARH4)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MARCH4 antibodies
     MARCH4 proteins
     MARCH4 lysates
     Antibodies for MARCH4
     See all of Abcam's Antibodies, Kits and Proteins for MARCH4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for MARCH4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH4
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MARCH4
     Browse SwitchGear Promoter luciferase reporter plasmids for MARCH4
     ThermoFisher Antibodies for MARCH4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MARCH4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MARCH4
    Customized:
     lentivirus for stable overexpression of MARCH4
     lentivirus expression plasmids for stable overexpression of MARCH4
     adenovirus for overexpression of MARCH4
     LSBio Antibodies in human, mouse, rat for MARCH4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MARCH4 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4