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MARCH4 Gene

protein-coding   GIFtS: 47
GCID: GC02M217122

Membrane-Associated Ring Finger (C3HC4) 4, E3 Ubiquitin...

(Previous name: membrane-associated ring finger (C3HC4) 4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Membrane-Associated Ring Finger (C3HC4) 4, E3 Ubiquitin Protein
Ligase1 2
     RING Finger Protein 1742 3
RNF1742 3 5     KIAA13993 5
Membrane-Associated RING Finger Protein 42 3     Membrane-Associated Ring Finger (C3HC4) 41
Membrane-Associated RING-CH Protein IV2 3     E3 Ubiquitin-Protein Ligase MARCH42
MARCH-IV2 3     EC 6.3.2.-3

External Ids:    HGNC: 292691   Entrez Gene: 575742   Ensembl: ENSG000001445837   OMIM: 6082085   UniProtKB: Q9P2E83   

Export aliases for MARCH4 gene to outside databases

Previous GC identifers: GC02M216949 GC02M216830 GC02M208976


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MARCH4 Gene:
MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add
ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport
between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing
them to the endosomal compartment (Bartee et al., 2004 (PubMed 14722266)).(supplied by OMIM, Apr 2010)

GeneCards Summary for MARCH4 Gene:
MARCH4 (membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is MARCH11.

UniProtKB/Swiss-Prot: MARH4_HUMAN, Q9P2E8
Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their
subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin
from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to
targeted substrates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the MARCH4 gene promoter:
         HOXA9B   HOXA9   Nkx3-1   Nkx3-1 v4   RREB-1   Nkx3-1 v1   C/EBPalpha   Nkx3-1 v2   SRY   Nkx3-1 v3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MARCH4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARCH4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

MARCH4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCH4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M217122:  view genomic region     (about GC identifiers)

Start:
217,122,585 bp from pter      End:
217,236,750 bp from pter
Size:
114,166 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MARH4_HUMAN, Q9P2E8 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MARCH4 precursor  
Size: 410 amino acids; 45528 Da
Sequence caution: Sequence=BAA92637.1; Type=Erroneous initiation;
Secondary accessions: Q4KMN7 Q86WR8

Explore the universe of human proteins at neXtProt for MARCH4: NX_Q9P2E8

Explore proteomics data for MARCH4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MARCH4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065865.1  
    ENSEMBL proteins: 
     ENSP00000273067  

    MARCH4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for MARCH4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MARCH4
    GenScript Custom Purified and Recombinant Proteins Services for MARCH4
    Novus Biologicals MARCH4 Protein
    Novus Biologicals MARCH4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MARCH4 

     
    antibodies-online proteins for MARCH4 (2 products) 

     
    antibodies-online peptides for MARCH4

    MARCH4 Antibody Products:

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    OriGene Antibodies for MARCH4
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    Novus Biologicals MARCH4 Antibodies
    Search for Antibodies for MARCH4 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for MARCH4
    antibodies-online antibodies for MARCH4 (43 products) 

    MARCH4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MARCH4
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for MARCH4 
    antibodies-online kits for MARCH4 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers
    MARCH: MARCH membrane-associated ring fingers

    2 InterPro protein domains:
     IPR013083 Znf_RING/FYVE/PHD
     IPR011016 Znf_RING-CH

    Graphical View of Domain Structure for InterPro Entry Q9P2E8

    ProtoNet protein and cluster: Q9P2E8

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB011016 RINGv


    UniProtKB/Swiss-Prot: MARH4_HUMAN, Q9P2E8
    Domain: The RING-CH-type zinc finger domain is required for E3 ligase activity
    Similarity: Contains 1 RING-CH-type zinc finger


    Find genes that share domains with MARCH4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARH4_HUMAN, Q9P2E8
    Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their
    subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin
    from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to
    targeted substrates

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA14722266
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with MARCH4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MARCH4:
     Increased circadian period len 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MARCH4

    miRNA
    Products:
        
    miRTarBase miRNAs that target MARCH4:
    hsa-mir-320a (MIRT044444), hsa-mir-373-3p (MIRT004073)

    Block miRNA regulation of human, mouse, rat MARCH4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MARCH4 (see all 48):
    hsa-miR-3607-3p hsa-miR-106a hsa-miR-548k hsa-miR-15a hsa-miR-25 hsa-miR-30d hsa-miR-218 hsa-miR-374c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MARCH4
    Predesigned siRNA for gene silencing in human, mouse, rat MARCH4

    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MARCH4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MARH4_HUMAN, Q9P2E8: Golgi apparatus membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular2
    plasma membrane2
    cytosol1
    endosome1
    lysosome1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005795Golgi stack IDA14722266
    GO:0005802trans-Golgi network IDA14722266
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with MARCH4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: MARH4_HUMAN, Q9P2E8
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MARCH4
    Interactions:

        Search GeneGlobe Interaction Network for MARCH4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MARCH4 (Q9P2E83 ENSP000002730674) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD4P017303, ENSP000000116534I2D: score=1 STRING: ENSP00000011653
    UBE2G2ENSP000003383484STRING: ENSP00000338348
    CSTF3ENSP000003157914STRING: ENSP00000315791
    NPLOC4ENSP000003314874STRING: ENSP00000331487
    UBE2J2ENSP000003837194STRING: ENSP00000383719
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MARCH4 (MARH4)

    4 HMDB Compounds for MARCH4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MARCH4 gene: 
    NM_020814.2  

    Unigene Cluster for MARCH4:

    Membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
    Hs.170388  [show with all ESTs]
    Unigene Representative Sequence: NM_020814
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000273067(uc002vgb.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MARCH4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MARCH4 (see all 48):
    hsa-miR-3607-3p hsa-miR-106a hsa-miR-548k hsa-miR-15a hsa-miR-25 hsa-miR-30d hsa-miR-218 hsa-miR-374c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MARCH4
    Predesigned siRNA for gene silencing in human, mouse, rat MARCH4
    Clone
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    GenScript Custom all cDNA clones Services for MARCH4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH4
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MARCH4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARCH4
      QuantiTect SYBR Green Assays in human, mouse, rat MARCH4
      QuantiFast Probe-based Assays in human, mouse, rat MARCH4

    Additional mRNA sequence: 

    AB037820.1 AL353945.1 BC048793.1 BC098448.1 U79281.1 

    1 DOTS entry:

    DT.311588 

    Selected AceView cDNA sequences (see all 40):

    BC048793 AA872140 AI084800 AA932963 AA878741 AA989244 D81241 AA829736 
    F10895 D81270 AW954545 BM554507 BM561212 AA349815 CA446657 AI372509 
    BV195149 AA976832 BX283349 BM810875 AB037820 BM558985 U79281 AA349816 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MARCH4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTATTAAAA
    MARCH4 Expression
    About this image


    MARCH4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells
     
     Neurons
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
    MARCH4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MARCH4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.170388

    UniProtKB/Swiss-Prot: MARH4_HUMAN, Q9P2E8
    Tissue specificity: Expressed in brain and placenta

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MARCH4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia March41 , 5 membrane-associated ring finger (C3HC4) 41, 5 88.72(n)1
    90.96(a)1
      1 (36.54 cM)5
    3812701  NM_001045533.11  NP_001038998.11 
     724271125 
    chicken
    (Gallus gallus)
    Aves MAR-041 membrane-associated ring finger (C3HC4) 4 77.91(n)
    82.39(a)
      424221  XM_422071.4  XP_422071.4 
    lizard
    (Anolis carolinensis)
    Reptilia MARCH46
    membrane-associated ring finger (C3HC4) 4, E3 ubiq...
    79(a)
    1 ↔ 1
    GL343344.1(1047541-1074824)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia march41 membrane-associated ring finger (C3HC4) 4, E3 ubiquitin more 71.31(n)
    76.04(a)
      100492913  XM_002942005.2  XP_002942051.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.184802 Transcribed sequence 81.51(n)    BQ284523.1 


    ENSEMBL Gene Tree for MARCH4 (if available)
    TreeFam Gene Tree for MARCH4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MARCH4 gene
    MARCH112  MARCH92  
    2 SIMAP similar genes for MARCH4 using alignment to 1 protein entry:     MARH4_HUMAN:
    MARCH9    MARCH11

    Find genes that share paralogs with MARCH4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MARCH4 (see all 2307)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1499992511,2
    --217122179(+) AACACC/TCCTCT 1 -- int10--------
    rs58385751,2
    C--217122187(+) GTGTG-/TGGCTTT 1 -- int10--------
    rs1472737931,2
    --217122216(+) TGAAAC/TGACCA 1 -- int10--------
    rs1852933871,2
    --217122229(+) TGAAGC/TGGAGC 1 -- int10--------
    rs1404780261,2
    --217122260(+) CCCATA/GGTCTC 1 -- int10--------
    rs1444296511,2
    --217122299(+) TGGGAC/GAGCCT 1 -- int10--------
    rs2063741,2
    C,F,A,H--217122402(-) GCAGGG/ATAGGC 1 -- int122Minor allele frequency- A:0.41NS EA NA WA CSA 2350
    rs2078681,2
    C,F,A,H--217122410(-) CGGACG/AGGGCA 1 -- int124Minor allele frequency- A:0.23NS EA NA WA CSA 2342
    rs1905964301,2
    --217122513(+) AGGGAG/TAAAGA 1 -- int10--------
    rs1478337731,2
    --217122588(+) ACTAAC/TGGTAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MARCH4 (217122585 - 217236750 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MARCH4 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721458CNV Deletion23290073
    esv2721460CNV Deletion23290073
    dgv673e201CNV Deletion23290073
    esv1006636CNV Deletion20482838
    esv2678065CNV Deletion23128226
    nsv507067CNV Insertion20534489
    nsv3160CNV Loss18451855
    nsv834537CNV Loss17160897
    nsv875845CNV Gain21882294
    nsv875843CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MARCH4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608208    OMIM disorders: --


    Find genes that share disorders with MARCH4           About GenesLikeMe


    Export disorders for MARCH4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MARCH4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MARCH4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PubMed id 14722266)1, 2, 3, 9 Bartee E.... Frueh K. (J. Virol. 2004)
    2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Genome-wide association analysis identifies susceptibility loci for migraine without aura. (PubMed id 22683712)1 Freilinger T....van den Maagdenberg A.M. (Nat. Genet. 2012)
    5. Membrane-Associated RING-CH proteins associate with Bap31 and target CD81 and CD44 to lysosomes. (PubMed id 21151997)1 Bartee E....FrA1h K. (PLoS ONE 2010)
    6. Stress-regulated targeting of the NKG2D ligand Mult1 by a membrane-associated RING-CH family E3 ligase. (PubMed id 20870941)1 Nice T.J....Raulet D.H. (J. Immunol. 2010)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (Genome Res. 1997)
    9. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57574 HGNC: 29269 AceView: MARCH-IV Ensembl:ENSG00000144583 euGenes: HUgn57574
    ECgene: MARCH4 H-InvDB: MARCH4

    (According to HUGE)
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    HUGE: KIAA1399

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MARCH4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MARCH4 gene:
    Search GeneIP for patents involving MARCH4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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