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Aliases for MARCH4 Gene

Aliases for MARCH4 Gene

  • Membrane-Associated Ring Finger (C3HC4) 4, E3 Ubiquitin Protein Ligase 2 3
  • RNF174 3 4 6
  • Membrane-Associated RING Finger Protein 4 3 4
  • Membrane-Associated RING-CH Protein IV 3 4
  • RING Finger Protein 174 3 4
  • MARCH-IV 3 4
  • KIAA1399 4 6
  • Membrane-Associated Ring Finger (C3HC4) 4 2
  • E3 Ubiquitin-Protein Ligase MARCH4 3
  • EC 6.3.2.- 4

External Ids for MARCH4 Gene

Summaries for MARCH4 Gene

Entrez Gene Summary for MARCH4 Gene

  • MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]

GeneCards Summary for MARCH4 Gene

MARCH4 (Membrane-Associated Ring Finger (C3HC4) 4, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is MARCH11.

UniProtKB/Swiss-Prot for MARCH4 Gene

  • E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH4 Gene

Genomics for MARCH4 Gene

Genomic Location for MARCH4 Gene

216,257,862 bp from pter
216,372,027 bp from pter
114,166 bases
Minus strand

Genomic View for MARCH4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARCH4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH4 Gene

Regulatory Elements for MARCH4 Gene

Proteins for MARCH4 Gene

  • Protein details for MARCH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase MARCH4
    Protein Accession:
    Secondary Accessions:
    • Q4KMN7
    • Q86WR8

    Protein attributes for MARCH4 Gene

    410 amino acids
    Molecular mass:
    45528 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA92637.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MARCH4 Gene

Proteomics data for MARCH4 Gene at MOPED

Post-translational modifications for MARCH4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MARCH4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MARCH4 Gene

Domains for MARCH4 Gene

Gene Families for MARCH4 Gene

  • RNF :RING-type (C3HC4) zinc fingers
  • MARCH :MARCH membrane-associated ring fingers

Protein Domains for MARCH4 Gene


  • The RING-CH-type zinc finger domain is required for E3 ligase activity:
    • Q9P2E8
  • Contains 1 RING-CH-type zinc finger.:
    • Q9P2E8
genes like me logo Genes that share domains with MARCH4: view

Function for MARCH4 Gene

Molecular function for MARCH4 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for MARCH4 Gene

Gene Ontology (GO) - Molecular Function for MARCH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 14722266
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with MARCH4: view

Phenotypes for MARCH4 Gene

GenomeRNAi human phenotypes for MARCH4:
genes like me logo Genes that share phenotypes with MARCH4: view

miRNA for MARCH4 Gene

miRTarBase miRNAs that target MARCH4

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MARCH4 Gene

Localization for MARCH4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCH4 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MARCH4 Gene COMPARTMENTS Subcellular localization image for MARCH4 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
plasma membrane 2
cytosol 1
endosome 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MARCH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005795 Golgi stack IDA 14722266
GO:0005802 trans-Golgi network IDA 14722266
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MARCH4: view

Pathways for MARCH4 Gene

SuperPathways for MARCH4 Gene

No Data Available

UniProtKB/Swiss-Prot Q9P2E8-MARH4_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for MARCH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MARCH4: view

No data available for Pathways by source for MARCH4 Gene

Compounds for MARCH4 Gene

(4) HMDB Compounds for MARCH4 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
Phosphoric acid
  • acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion
genes like me logo Genes that share compounds with MARCH4: view

Transcripts for MARCH4 Gene

mRNA/cDNA for MARCH4 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MARCH4 Gene

Membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH4 Gene

No ASD Table

Relevant External Links for MARCH4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MARCH4 Gene

mRNA expression in normal human tissues for MARCH4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MARCH4 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (5.1), Brain - Cortex (4.8), Brain - Anterior cingulate cortex (BA24) (4.2), and Pituitary (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MARCH4 Gene

SOURCE GeneReport for Unigene cluster for MARCH4 Gene Hs.170388

mRNA Expression by UniProt/SwissProt for MARCH4 Gene

Tissue specificity: Expressed in brain and placenta.
genes like me logo Genes that share expressions with MARCH4: view

Orthologs for MARCH4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCH4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MARCH4 36
  • 100 (n)
  • 100 (a)
  • 99 (a)
(Bos Taurus)
Mammalia MARCH4 36
  • 91.58 (n)
  • 92.4 (a)
  • 90 (a)
(Canis familiaris)
Mammalia MARCH4 36
  • 91.54 (n)
  • 91.46 (a)
  • 88 (a)
(Mus musculus)
Mammalia March4 36
  • 88.72 (n)
  • 90.96 (a)
March4 16
March4 37
  • 87 (a)
(Monodelphis domestica)
Mammalia MARCH4 37
  • 81 (a)
(Rattus norvegicus)
Mammalia March4 36
  • 88.77 (n)
  • 90.93 (a)
(Gallus gallus)
Aves MAR-04 36
  • 77.91 (n)
  • 82.39 (a)
  • 80 (a)
(Anolis carolinensis)
Reptilia MARCH4 37
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia march4 36
  • 71.31 (n)
  • 76.04 (a)
(Danio rerio)
Actinopterygii Dr.18480 36
march4 37
  • 55 (a)
MARCH4 (1 of 2) 37
  • 52 (a)
zgc:153256 36
  • 64.28 (n)
  • 63.66 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 27 (a)
Species with no ortholog for MARCH4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARCH4 Gene

Gene Tree for MARCH4 (if available)
Gene Tree for MARCH4 (if available)

Paralogs for MARCH4 Gene

Paralogs for MARCH4 Gene

Selected SIMAP similar genes for MARCH4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MARCH4: view

Variants for MARCH4 Gene

Sequence variations from dbSNP and Humsavar for MARCH4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs83610 -- 216,285,665(-) CAAAT(A/G)CCCAG intron-variant
rs83611 -- 216,285,791(-) TGCCA(C/T)GAATA intron-variant
rs83612 -- 216,285,800(-) AGGAA(A/T)TGCTG intron-variant
rs124826 -- 216,285,298(+) GCAAT(A/G)AATGA intron-variant
rs124827 -- 216,285,362(+) ACTCT(C/G)CTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH4 Gene

Variant ID Type Subtype PubMed ID
nsv507067 CNV Insertion 20534489
nsv834537 CNV Loss 17160897
nsv875843 CNV Gain 21882294
nsv875844 CNV Gain 21882294
esv2721458 CNV Deletion 23290073
dgv673e201 CNV Deletion 23290073
esv2721460 CNV Deletion 23290073
esv1006636 CNV Deletion 20482838
esv2678065 CNV Deletion 23128226
nsv3160 CNV Loss 18451855
nsv875845 CNV Gain 21882294

Relevant External Links for MARCH4 Gene

HapMap Linkage Disequilibrium report

Disorders for MARCH4 Gene

No disorders were found for MARCH4 Gene.

No data available for UniProtKB/Swiss-Prot for MARCH4 Gene

Publications for MARCH4 Gene

  1. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E. … Frueh K. (J. Virol. 2004) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Stress-regulated targeting of the NKG2D ligand Mult1 by a membrane-associated RING-CH family E3 ligase. (PMID: 20870941) Nice T.J. … Raulet D.H. (J. Immunol. 2010) 3
  5. Membrane-Associated RING-CH proteins associate with Bap31 and target CD81 and CD44 to lysosomes. (PMID: 21151997) Bartee E. … FrA1h K. (PLoS ONE 2010) 3

Products for MARCH4 Gene

Sources for MARCH4 Gene

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