Aliases for MARCH3 Gene
External Ids for MARCH3 Gene
Previous GeneCards Identifiers for MARCH3 Gene
This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013]
GeneCards Summary for MARCH3 Gene
MARCH3 (Membrane Associated Ring-CH-Type Finger 3) is a Protein Coding gene. Diseases associated with MARCH3 include Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is MARCH2.
UniProtKB/Swiss-Prot for MARCH3 Gene
E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.