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MARCH3 Gene

protein-coding   GIFtS: 45
GCID: GC05M126235

Membrane-Associated Ring Finger (C3HC4) 3, E3 Ubiquitin...

(Previous name: membrane-associated ring finger (C3HC4) 3)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Membrane-Associated Ring Finger (C3HC4) 3, E3 Ubiquitin Protein
Ligase1 2
     Membrane-Associated Ring Finger (C3HC4) 31
Membrane-Associated RING-CH Protein III2 3     E3 Ubiquitin-Protein Ligase MARCH32
MARCH-III2 3     EC 6.3.2.-3
RNF1732 3     Membrane-Associated RING Finger Protein 33
RING Finger Protein 1732 3     EC 6.3.28

External Ids:    HGNC: 287281   Entrez Gene: 1151232   Ensembl: ENSG000001739267   OMIM: 6133335   UniProtKB: Q86UD33   

Export aliases for MARCH3 gene to outside databases

Previous GC identifer: GC05M121395


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MARCH3 Gene:
This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3
ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. (provided by
RefSeq, Mar 2013)

GeneCards Summary for MARCH3 Gene:
MARCH3 (membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase) is a protein-coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is MARCH8.

UniProtKB/Swiss-Prot: MARH3_HUMAN, Q86UD3
Function: E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept
ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the
ubiquitin to targeted substrates (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MARCH3 gene promoter:
         HFH-3   GATA-3   IRF-1   E47   GATA-2   GATA-1   MZF-1   FOXI1   FOXO1a   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MARCH3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARCH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.2   Ensembl cytogenetic band:  5q23.2   HGNC cytogenetic band: 5q23.2

MARCH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCH3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M126235:  view genomic region     (about GC identifiers)

Start:
126,203,406 bp from pter      End:
126,366,500 bp from pter
Size:
163,095 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MARH3_HUMAN, Q86UD3 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MARCH3  
Size: 253 amino acids; 28504 Da
Subunit: Interacts with MARCH2 and STX6 (By similarity)
Secondary accessions: A8K264

Explore the universe of human proteins at neXtProt for MARCH3: NX_Q86UD3

Explore proteomics data for MARCH3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MARCH3 (Q86UD3) (see all 9)
     CRICHEG  HEKRTLF  EWRRTNQ  LEAVGLIALT 


    See MARCH3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_848545.1  
    ENSEMBL proteins: 
     ENSP00000309141   ENSP00000421979  

    MARCH3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MARCH3
    OriGene Protein Over-expression Lysate for MARCH3
    OriGene MassSpec for MARCH3
    OriGene Custom Protein Services for MARCH3
    GenScript Custom Purified and Recombinant Proteins Services for MARCH3
    Novus Biologicals MARCH3 Proteins
    Novus Biologicals MARCH3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    MARCH3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MARCH3
    OriGene Custom Antibody Services for MARCH3
    Novus Biologicals MARCH3 Antibodies
    Search for Antibodies for MARCH3 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for MARCH3
    Search LSBio for Antibodies for MARCH3

    MARCH3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MARCH3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MARCH3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers
    MARCH: MARCH membrane-associated ring fingers

    2 InterPro protein domains:
     IPR013083 Znf_RING/FYVE/PHD
     IPR011016 Znf_RING-CH

    Graphical View of Domain Structure for InterPro Entry Q86UD3

    ProtoNet protein and cluster: Q86UD3

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB011016 RINGv


    UniProtKB/Swiss-Prot: MARH3_HUMAN, Q86UD3
    Domain: The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity)
    Similarity: Contains 1 RING-CH-type zinc finger


    MARCH3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARH3_HUMAN, Q86UD3
    Function: E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept
    ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the
    ubiquitin to targeted substrates (By similarity)

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    MARCH3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MARCH3:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MARCH3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MARCH3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARCH3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARCH3

    miRNA
    Products:
        
    miRTarBase miRNAs that target MARCH3:
    hsa-mir-744-5p (MIRT037720), hsa-mir-26b-5p (MIRT028807)

    Block miRNA regulation of human, mouse, rat MARCH3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MARCH3 (see all 74):
    hsa-miR-124* hsa-miR-194* hsa-miR-607 hsa-miR-3653 hsa-miR-30d hsa-miR-4275 hsa-miR-30a hsa-miR-1243
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MARCH3
    Predesigned siRNA for gene silencing in human, mouse, rat MARCH3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MARCH3

    Clone
    Products:
         
    OriGene clones in human, mouse for MARCH3 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MARCH3
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MARCH3
    Browse ESI BIO Cell Lines and PureStem Progenitors for MARCH3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MARH3_HUMAN, Q86UD3: Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome membrane;
    Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    lysosome5
    vacuole5
    plasma membrane3
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome IDA14722266
    GO:0005768endosome IDA14722266
    GO:0016021integral component of membrane IEA--
    GO:0030659cytoplasmic vesicle membrane IEA--
    GO:0031901early endosome membrane IEA--

    MARCH3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: MARH3_HUMAN, Q86UD3
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including MARCH3: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MARCH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MARCH3 (Q86UD33 ENSP000003091414) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    UBE2D4Q9Y2X83, ENSP000002224024I2D: score=2 STRING: ENSP00000222402
    UBE2E1P519653, ENSP000003037094I2D: score=2 STRING: ENSP00000303709
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0016567protein ubiquitination IEA--

    MARCH3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MARCH3 (MARH3)

    4 HMDB Compounds for MARCH3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MARCH3 gene: 
    NM_178450.4  

    Unigene Cluster for MARCH3:

    Membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
    Hs.132441  [show with all ESTs]
    Unigene Representative Sequence: NM_178450
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308660(uc003kuf.3 uc011cxc.1) ENST00000506088 ENST00000504239
    ENST00000515241 ENST00000502289
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MARCH3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MARCH3 (see all 74):
    hsa-miR-124* hsa-miR-194* hsa-miR-607 hsa-miR-3653 hsa-miR-30d hsa-miR-4275 hsa-miR-30a hsa-miR-1243
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MARCH3
    Predesigned siRNA for gene silencing in human, mouse, rat MARCH3
    Clone
    Products:
         
    OriGene clones in human, mouse for MARCH3 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MARCH3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MARCH3
    OriGene qSTAR qPCR primer pairs in human, mouse for MARCH3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARCH3
      QuantiTect SYBR Green Assays in human, mouse, rat MARCH3
      QuantiFast Probe-based Assays in human, mouse, rat MARCH3

    Additional mRNA sequence: 

    AF055007.1 AK000103.1 AK290129.1 BC047569.1 BC146948.1 BC146964.1 

    7 DOTS entries:

    DT.312594  DT.311012  DT.97842964  DT.91749833  DT.99926902  DT.120883567  DT.120883621 

    Selected AceView cDNA sequences (see all 85):

    BQ641458 AW051764 AI215020 AI918773 CA306167 BM931562 BE408696 AI203073 
    BM790732 BQ014016 BM727738 BM682935 AI347342 BU735044 AI492023 CA444753 
    BF063553 BG200932 AV707675 BE514584 BM696411 CD674715 CK820969 AI376818 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MARCH3 expression in normal human tissues (normalized intensities)      MARCH3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTATTTAGC
    MARCH3 Expression
    About this image


    MARCH3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Germ Cells (Reproductive System)
             Primordial germ cell-like cells
     
     Gonad
             Primordial germ cell-like cells
     
     Blood (Hematopoietic System)
             Erythroblasts Hematopoietic Bone Marrow
    MARCH3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MARCH3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.132441
        Pathway & Disease-focused RT2 Profiler PCR Array including MARCH3: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MARCH3
    OriGene qSTAR qPCR primer pairs in human, mouse for MARCH3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARCH3
    QuantiTect SYBR Green Assays in human, mouse, rat MARCH3
    QuantiFast Probe-based Assays in human, mouse, rat MARCH3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MARCH3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia March31 , 5 membrane-associated ring finger (C3HC4) 31, 5 91.55(n)1
    93.55(a)1
      18 (30.92 cM)5
    3202531  NM_177115.21  NP_796089.11 
     567617165 
    chicken
    (Gallus gallus)
    Aves MARCH31 membrane-associated ring finger (C3HC4) 3 85.24(n)
    94.06(a)
      768965  XM_001232134.3  XP_001232135.3 
    lizard
    (Anolis carolinensis)
    Reptilia MARCH36
    membrane-associated ring finger (C3HC4) 3, E3 ubiq...
    96(a)
    1 ↔ 1
    2(29347947-29514057)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia march31 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin more 82.2(n)
    94.82(a)
      493225  NM_001007498.1  NP_001007499.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1587856
    zgc:158785
    48(a)
    many ↔ many
    7(13627027-13641567) ENSDARG00000062959
    worm
    (Caenorhabditis elegans)
    Secernentea marc-36
    Protein C17E4.3 (C17E4.3) mRNA, complete cds
    16(a)
    1 → many
    I(9416703-9418876) WBGene00007643
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSM46
    Ubiquitin-protein ligase involved in ER-associated...
    3(a)
    1 → many
    IX(296050-300009) YIL030C


    ENSEMBL Gene Tree for MARCH3 (if available)
    TreeFam Gene Tree for MARCH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MARCH3 gene
    MARCH82  MARCH62  MARCH12  MARCH22  
    4 SIMAP similar genes for MARCH3 using alignment to 2 protein entries:     MARH3_HUMAN (see all proteins):
    MARCH2    MARCH1    MARCH8    MARCH6

    MARCH3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MARCH3 (see all 3071)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs340900361,2
    C--121444003(+) GACAG-/ACACACACACAC
    ACACACACACACAC
    ACACA
    1 -- int10--------
    rs2003007541,2
    C--121507285(-) CATTTC/TTTTTT 1 -- int10--------
    rs339219371,2
    C--121517394(+) CCCCA-/TTTAAC 1 -- int10--------
    rs561790441,2
    C--121517397(+) CATTTG/AACAAG 1 -- int11Minor allele frequency- A:0.00NA 2
    rs106539811,2
    C--126205275(+) ttttt-/TTT/TT
    TTTTTTTTT
    ttttt
    2 -- cds1 ut311NA 2
    rs769524251,2
    C--126217206(+) AGCAA-/ATATGG 1 -- int10--------
    rs1130248611,2
    C--126226113(+) TCCCAG/ATGCTA 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1130721611,2
    C--126226157(+) CCAGAG/CTGTGA 1 -- int11Minor allele frequency- C:0.00CSA 1
    rs96862291,2
    C--126227097(+) tctagC/Ggtttt 1 -- int10--------
    rs611718521,2
    C--126236313(+) TCATT-/TATAGT 1 -- int12Minor allele frequency- T:0.00NA CSA 4

    HapMap Linkage Disequilibrium report for MARCH3 (126203406 - 126366500 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MARCH3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv268429CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MARCH3
    DNA2.0 Custom Variant and Variant Library Synthesis for MARCH3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613333    OMIM disorders: --


    MARCH3 for disorders           About GeneDecksing


    Export disorders for MARCH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MARCH3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MARCH3)
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    world of online information

    1. MARCH-III is a novel component of endosomes with properties similar to those of MARCH-II. (PubMed id 16428329)1, 2 Fukuda H.... Hirose S. (J. Biochem. 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PubMed id 14722266)1, 3 Bartee E.... Frueh K. (J. Virol. 2004)
    4. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    6. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (Genome Res. 2009)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (Genome Res. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 115123 HGNC: 28728 AceView: MARCH-III Ensembl:ENSG00000173926 euGenes: HUgn115123
    ECgene: MARCH3 H-InvDB: MARCH3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MARCH3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MARCH3 gene:
    Search GeneIP for patents involving MARCH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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