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Aliases for MARCH3 Gene

Aliases for MARCH3 Gene

  • Membrane Associated Ring-CH-Type Finger 3 2 3 5
  • Membrane-Associated Ring Finger (C3HC4) 3, E3 Ubiquitin Protein Ligase 2 3
  • Membrane-Associated RING-CH Protein III 3 4
  • RING Finger Protein 173 3 4
  • MARCH-III 3 4
  • RNF173 3 4
  • Membrane-Associated Ring Finger (C3HC4) 3 2
  • Membrane-Associated RING Finger Protein 3 4
  • E3 Ubiquitin-Protein Ligase MARCH3 3
  • Membrane Associated Ring Finger 3 3
  • EC 6.3.2.- 4
  • EC 6.3.2 61

External Ids for MARCH3 Gene

Previous GeneCards Identifiers for MARCH3 Gene

  • GC05M126235
  • GC05M121395

Summaries for MARCH3 Gene

Entrez Gene Summary for MARCH3 Gene

  • This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013]

GeneCards Summary for MARCH3 Gene

MARCH3 (Membrane Associated Ring-CH-Type Finger 3) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is MARCH2.

UniProtKB/Swiss-Prot for MARCH3 Gene

  • E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH3 Gene

Genomics for MARCH3 Gene

Regulatory Elements for MARCH3 Gene

Enhancers for MARCH3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F127009 0.8 Ensembl ENCODE 66.4 +20.4 20377 4.1 TBP TBL1XR1 JUN MAX ZBTB40 YY1 CBX5 EED FOS NFE2 MARCH3 GC05M127022 GC05M126868
GH05F126997 0.8 Ensembl ENCODE 66.3 +33.7 33717 1.4 TBP HDAC1 ARNT CREB3L1 NFRKB RAD21 YY1 GATA2 MBD2 SMARCA4 MARCH3 GC05M127022 GC05M126868
GH05F126987 0.8 Ensembl ENCODE 66 +44.0 43956 2.7 PKNOX1 TBL1XR1 RELA EED ETV6 CREM SRF MAZ MTA2 CBFB MARCH3 GC05M127022 GC05M126868
GH05F126969 1.2 Ensembl ENCODE 66 +60.6 60602 4.0 PKNOX1 ATF1 ARNT SIN3A ELK1 GATA2 CBX5 ZNF207 KLF13 JUNB MARCH3 C5orf63 GC05M127022 GC05M126868
GH05F127072 0.5 ENCODE 61.5 -41.0 -40961 1.4 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 SLC30A9 GLIS2 ELK1 ZHX2 MARCH3 C5orf63
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MARCH3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MARCH3 Gene

Chromosome:
5
Start:
126,867,714 bp from pter
End:
127,032,402 bp from pter
Size:
164,689 bases
Orientation:
Minus strand

Genomic View for MARCH3 Gene

Genes around MARCH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH3 Gene

Proteins for MARCH3 Gene

  • Protein details for MARCH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UD3-MARH3_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MARCH3
    Protein Accession:
    Q86UD3
    Secondary Accessions:
    • A8K264
    • B9EJE7

    Protein attributes for MARCH3 Gene

    Size:
    253 amino acids
    Molecular mass:
    28504 Da
    Quaternary structure:
    • Interacts with MARCH2 and STX6.

    Alternative splice isoforms for MARCH3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARCH3 Gene

Post-translational modifications for MARCH3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MARCH3 Gene

Protein Domains for MARCH3 Gene

Graphical View of Domain Structure for InterPro Entry

Q86UD3

UniProtKB/Swiss-Prot:

MARH3_HUMAN :
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
  • Contains 1 RING-CH-type zinc finger.
Domain:
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
Similarity:
  • Contains 1 RING-CH-type zinc finger.
genes like me logo Genes that share domains with MARCH3: view

No data available for Suggested Antigen Peptide Sequences for MARCH3 Gene

Function for MARCH3 Gene

Molecular function for MARCH3 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity).

Enzyme Numbers (IUBMB) for MARCH3 Gene

Gene Ontology (GO) - Molecular Function for MARCH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MARCH3: view
genes like me logo Genes that share phenotypes with MARCH3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MARCH3 Gene

Localization for MARCH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCH3 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MARCH3 Gene COMPARTMENTS Subcellular localization image for MARCH3 gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for MARCH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 14722266
GO:0005768 endosome IEA,IDA 14722266
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with MARCH3: view

Pathways & Interactions for MARCH3 Gene

SuperPathways for MARCH3 Gene

No Data Available

UniProtKB/Swiss-Prot Q86UD3-MARH3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MARCH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MARCH3: view

No data available for Pathways by source and SIGNOR curated interactions for MARCH3 Gene

Drugs & Compounds for MARCH3 Gene

(3) Drugs for MARCH3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for MARCH3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with MARCH3: view

Transcripts for MARCH3 Gene

Unigene Clusters for MARCH3 Gene

Membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH3 Gene

No ASD Table

Relevant External Links for MARCH3 Gene

GeneLoc Exon Structure for
MARCH3
ECgene alternative splicing isoforms for
MARCH3

Expression for MARCH3 Gene

mRNA expression in normal human tissues for MARCH3 Gene

mRNA differential expression in normal tissues according to GTEx for MARCH3 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.0).

SOURCE GeneReport for Unigene cluster for MARCH3 Gene:

Hs.132441
genes like me logo Genes that share expression patterns with MARCH3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MARCH3 Gene

Orthologs for MARCH3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MARCH3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARCH3 34 35
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia MARCH3 34 35
  • 95.65 (n)
rat
(Rattus norvegicus)
Mammalia March3 34
  • 94.73 (n)
cow
(Bos Taurus)
Mammalia MARCH3 34 35
  • 94.33 (n)
mouse
(Mus musculus)
Mammalia March3 34 16 35
  • 91.55 (n)
chicken
(Gallus gallus)
Aves MARCH3 34 35
  • 85.24 (n)
lizard
(Anolis carolinensis)
Reptilia MARCH3 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia march3 34
  • 82.2 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:158785 35
  • 48 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea marc-3 35
  • 16 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSM4 35
  • 3 (a)
OneToMany
Species where no ortholog for MARCH3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARCH3 Gene

ENSEMBL:
Gene Tree for MARCH3 (if available)
TreeFam:
Gene Tree for MARCH3 (if available)

Paralogs for MARCH3 Gene

Paralogs for MARCH3 Gene

(4) SIMAP similar genes for MARCH3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MARCH3: view

Variants for MARCH3 Gene

Sequence variations from dbSNP and Humsavar for MARCH3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10038419 -- 126,945,689(+) AAAGG(C/T)TGTAA intron-variant
rs10040840 -- 126,888,698(+) TAGAA(G/T)AAATT intron-variant
rs10053382 -- 126,987,293(+) TAATA(C/T)AGGGT intron-variant
rs10055344 -- 126,913,977(+) CCAAC(C/T)TTTTT intron-variant
rs10055771 -- 126,938,715(+) ATTTT(C/T)CCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH3 Gene

Variant ID Type Subtype PubMed ID
esv3304150 CNV mobile element insertion 20981092
esv3330842 CNV duplication 20981092
esv3358268 CNV insertion 20981092
esv3570411 CNV loss 25503493
esv3606694 CNV loss 21293372
esv3606695 CNV gain 21293372
esv3606698 CNV loss 21293372
nsv1124923 CNV duplication 24896259
nsv1146007 CNV duplication 26484159

Variation tolerance for MARCH3 Gene

Residual Variation Intolerance Score: 18.8% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MARCH3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MARCH3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH3 Gene

Disorders for MARCH3 Gene

Relevant External Links for MARCH3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MARCH3

No disorders were found for MARCH3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MARCH3 Gene

Publications for MARCH3 Gene

  1. MARCH-III is a novel component of endosomes with properties similar to those of MARCH-II. (PMID: 16428329) Fukuda H. … Hirose S. (J. Biochem. 2006) 3 4 64
  2. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E. … Frueh K. (J. Virol. 2004) 2 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3 64
  5. Toll-like Receptor 4 Ligands Down-regulate FcI^ Receptor IIb (FcI^RIIb) via MARCH3 Protein-mediated Ubiquitination. (PMID: 26694610) Fatehchand K. … Butchar J.P. (J. Biol. Chem. 2016) 3 64

Products for MARCH3 Gene

Sources for MARCH3 Gene

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