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Aliases for MARCH3 Gene

Aliases for MARCH3 Gene

  • Membrane-Associated Ring Finger (C3HC4) 3, E3 Ubiquitin Protein Ligase 2 3
  • Membrane-Associated RING-CH Protein III 3 4
  • RING Finger Protein 173 3 4
  • MARCH-III 3 4
  • RNF173 3 4
  • Membrane-Associated Ring Finger (C3HC4) 3 2
  • Membrane-Associated RING Finger Protein 3 4
  • E3 Ubiquitin-Protein Ligase MARCH3 3
  • EC 6.3.2.- 4
  • EC 6.3.2 64

External Ids for MARCH3 Gene

Summaries for MARCH3 Gene

Entrez Gene Summary for MARCH3 Gene

  • This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013]

GeneCards Summary for MARCH3 Gene

MARCH3 (Membrane-Associated Ring Finger (C3HC4) 3, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is MARCH2.

UniProtKB/Swiss-Prot for MARCH3 Gene

  • E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH3 Gene

Genomics for MARCH3 Gene

Genomic Location for MARCH3 Gene

126,867,714 bp from pter
127,030,808 bp from pter
163,095 bases
Minus strand

Genomic View for MARCH3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARCH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH3 Gene

Regulatory Elements for MARCH3 Gene

Proteins for MARCH3 Gene

  • Protein details for MARCH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase MARCH3
    Protein Accession:
    Secondary Accessions:
    • A8K264
    • B9EJE7

    Protein attributes for MARCH3 Gene

    253 amino acids
    Molecular mass:
    28504 Da
    Quaternary structure:
    • Interacts with MARCH2 and STX6.

    Alternative splice isoforms for MARCH3 Gene


neXtProt entry for MARCH3 Gene

Proteomics data for MARCH3 Gene at MOPED

Post-translational modifications for MARCH3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MARCH3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for MARCH3 Gene

Gene Families for MARCH3 Gene

  • RNF :RING-type (C3HC4) zinc fingers
  • MARCH :MARCH membrane-associated ring fingers

Protein Domains for MARCH3 Gene


  • The RING-CH-type zinc finger domain is required for E3 ligase activity.:
    • Q86UD3
  • Contains 1 RING-CH-type zinc finger.:
    • Q86UD3
genes like me logo Genes that share domains with MARCH3: view

Function for MARCH3 Gene

Molecular function for MARCH3 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity).

Enzyme Numbers (IUBMB) for MARCH3 Gene

Gene Ontology (GO) - Molecular Function for MARCH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with MARCH3: view

Phenotypes for MARCH3 Gene

GenomeRNAi human phenotypes for MARCH3:
genes like me logo Genes that share phenotypes with MARCH3: view

miRNA for MARCH3 Gene

miRTarBase miRNAs that target MARCH3

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MARCH3 Gene

Localization for MARCH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCH3 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MARCH3 Gene COMPARTMENTS Subcellular localization image for MARCH3 gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for MARCH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 14722266
GO:0005768 endosome IDA 14722266
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with MARCH3: view

Pathways for MARCH3 Gene

SuperPathways for MARCH3 Gene

No Data Available

UniProtKB/Swiss-Prot Q86UD3-MARH3_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for MARCH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MARCH3: view

No data available for Pathways by source for MARCH3 Gene

Compounds for MARCH3 Gene

(4) HMDB Compounds for MARCH3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
Phosphoric acid
  • acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion
genes like me logo Genes that share compounds with MARCH3: view

Transcripts for MARCH3 Gene

Unigene Clusters for MARCH3 Gene

Membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH3 Gene

No ASD Table

Relevant External Links for MARCH3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MARCH3 Gene

mRNA expression in normal human tissues for MARCH3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MARCH3 Gene

This gene is overexpressed in Heart - Left Ventricle (4.0).

SOURCE GeneReport for Unigene cluster for MARCH3 Gene Hs.132441

genes like me logo Genes that share expressions with MARCH3: view

Orthologs for MARCH3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MARCH3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MARCH3 36
  • 99.6 (n)
  • 99.6 (a)
  • 100 (a)
(Bos Taurus)
Mammalia MARCH3 36
  • 94.33 (n)
  • 98.02 (a)
  • 98 (a)
(Canis familiaris)
Mammalia MARCH3 36
  • 95.65 (n)
  • 98.81 (a)
  • 99 (a)
(Mus musculus)
Mammalia March3 36
  • 91.55 (n)
  • 93.55 (a)
March3 16
March3 37
  • 93 (a)
(Rattus norvegicus)
Mammalia March3 36
  • 94.73 (n)
  • 98.81 (a)
(Gallus gallus)
Aves MARCH3 36
  • 85.24 (n)
  • 94.06 (a)
  • 85 (a)
(Anolis carolinensis)
Reptilia MARCH3 37
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia march3 36
  • 82.2 (n)
  • 94.82 (a)
(Danio rerio)
Actinopterygii zgc:158785 37
  • 48 (a)
(Caenorhabditis elegans)
Secernentea marc-3 37
  • 16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSM4 37
  • 3 (a)
Species with no ortholog for MARCH3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARCH3 Gene

Gene Tree for MARCH3 (if available)
Gene Tree for MARCH3 (if available)

Paralogs for MARCH3 Gene

Paralogs for MARCH3 Gene

Selected SIMAP similar genes for MARCH3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MARCH3: view

Variants for MARCH3 Gene

Sequence variations from dbSNP and Humsavar for MARCH3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs3533 -- 126,867,814(+) GATGC(C/T)CTGTG utr-variant-3-prime
rs729607 -- 126,999,171(-) GCCCC(A/G)ACTGA intron-variant
rs886857 -- 126,978,383(-) CCCTA(C/T)TCTTC intron-variant
rs1013662 -- 127,028,162(-) ATGGG(C/T)GGAAT intron-variant
rs1034844 -- 126,976,696(-) AATTG(G/T)GTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH3 Gene

Variant ID Type Subtype PubMed ID
esv268429 CNV Insertion 20981092

Relevant External Links for MARCH3 Gene

HapMap Linkage Disequilibrium report

Disorders for MARCH3 Gene

No disorders were found for MARCH3 Gene.

No data available for UniProtKB/Swiss-Prot for MARCH3 Gene

Publications for MARCH3 Gene

  1. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E. … Frueh K. (J. Virol. 2004) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. MARCH-III is a novel component of endosomes with properties similar to those of MARCH-II. (PMID: 16428329) Fukuda H. … Hirose S. (J. Biochem. 2006) 3 4
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  5. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 3

Products for MARCH3 Gene

Sources for MARCH3 Gene

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