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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MARCH3 Gene

protein-coding   GIFtS: 44
GCID: GC05M126235

membrane-associated ring finger (C3HC4) 3, E3 ubiquitin...

(Previous name: membrane-associated ring finger (C3HC4) 3 )
  Search for MARCH3
in
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Biological research products
for MARCH3    

Aliases
for MARCH3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Membrane-Associated Ring Finger (C3HC4) 3, E3 Ubiquitin Protein Ligase1 2     MGC483321
MARCH-III1 2 3     Membrane-Associated Ring Finger (C3HC4) 31
RNF1731 2 3     E3 Ubiquitin-Protein Ligase MARCH32
Membrane-Associated RING Finger Protein 32 3     EC 6.3.2.-3
Membrane-Associated RING-CH Protein III2 3     EC 6.3.28
RING Finger Protein 1732 3     

External Ids:    HGNC: 287281   Entrez Gene: 1151232   Ensembl: ENSG000001739267   OMIM: 6133335   UniProtKB: Q86UD33   

Export aliases for MARCH3 gene to outside databases

Previous GC identifer: GC05M121395


Summaries
for MARCH3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MARCH3:
MARCH3 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add
ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport
between membrane compartments. MARCH3 appears to function in the endosomal recycling pathway (Fukuda et al., 2006
(PubMed 16428329)).(supplied by OMIM, Mar 2010)

UniProtKB/Swiss-Prot: MARH3_HUMAN, Q86UD3
Function: E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept
ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin
to targeted substrates (By similarity)




Genomic Views
for MARCH3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MARCH3 gene promoter:
         HFH-3   GATA-3   IRF-1   E47   GATA-2   GATA-1   MZF-1   FOXI1   FOXO1a   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MARCH3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARCH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.2   Ensembl cytogenetic band:  5q23.2   HGNC cytogenetic band: 5q23.2

MARCH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCH3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M126235:  view genomic region     (about GC identifiers)

Start:
 126,203,406 bp from pter      End:
 126,366,500 bp from pter
Size:
 163,095 bases      Orientation:
 minus strand

Proteins
for MARCH3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MARH3_HUMAN, Q86UD3 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MARCH3  
Size: 253 amino acids; 28504 Da
Subunit: Interacts with MARCH2 and STX6 (By similarity)
Subcellular location: Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass
membrane protein
Secondary accessions: A8K264

Explore the universe of human proteins at neXtProt for MARCH3: NX_Q86UD3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86UD3

    • 4/9 DME Specific Peptides for MARCH3 (Q86UD3) (see all 9)
     CRICHEG  HEKRTLF  EWRRTNQ  LEAVGLIALT 

    MARCH3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_848545.1  
    ENSEMBL proteins: 
     ENSP00000309141   ENSP00000421979  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: MARCH3
    OriGene Protein Over-expression Lysate: MARCH3
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    GenScript Custom Purified and Recombinant Proteins Services for MARCH3
    Novus Biologicals MARCH3 Proteins
    Novus Biologicals MARCH3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome IDA14722266
    GO:0005768endosome IDA14722266
    GO:0016021integral to membrane IEA--
    GO:0030659cytoplasmic vesicle membrane IEA--
    GO:0031901early endosome membrane IEA--


    MARCH3 for ontologies           About GeneDecksing



    MARCH3 Antibody Products: 
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    Protein Domains /
    Families
    for MARCH3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MARCH3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR013083 Znf_RING/FYVE/PHD
     IPR011016 Znf_RING-CH

    Graphical View of Domain Structure for InterPro Entry Q86UD3

    ProtoNet protein and cluster: Q86UD3

    2 Blocks protein families:
    IPB001841 Zn-finger
    IPB011016 RINGv


    UniProtKB/Swiss-Prot: MARH3_HUMAN, Q86UD3
    Domain: The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity)
    Similarity: Contains 1 RING-CH-type zinc finger


    Function
    for MARCH3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MARH3_HUMAN, Q86UD3
    Function: E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept
    ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin
    to targeted substrates (By similarity)

    Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MARCH3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARCH3
    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate MARCH3 (see all 74):
    hsa-miR-124* hsa-miR-194* hsa-miR-607 hsa-miR-3653 hsa-miR-30d hsa-miR-4275 hsa-miR-30a hsa-miR-1243
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MARCH3
    OriGene shRNA RFP: MARCH3
    OriGene siRNA: MARCH3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARCH3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MARCH3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MARCH3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH3 

    Cell Line
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    Search LifeMap BioReagents cell lines for MARCH3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH3

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--


    MARCH3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MARCH3:
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for MARCH3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: MARH3_HUMAN, Q86UD3
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MARCH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for MARCH3 (Q86UD33 ENSP000003091414) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    UBE2D4Q9Y2X83, ENSP000002224024I2D: score=2 STRING: ENSP00000222402
    UBE2E1P519653, ENSP000003037094I2D: score=2 STRING: ENSP00000303709
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0016567protein ubiquitination IEA--


    MARCH3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MARCH3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MARCH3

    4 HMDB Compounds for MARCH3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about MARCH3 / MARH3 

    Transcripts
    for MARCH3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MARCH3 gene: 
    NM_178450.3  

    Unigene Cluster for MARCH3:

    Membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
    Hs.132441  [show with all ESTs]
    Unigene Representative Sequence: NM_178450
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308660(uc003kuf.3 uc011cxc.1) ENST00000506088 ENST00000504239
    ENST00000515241 ENST00000502289

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARCH3
    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate MARCH3 (see all 74):
    hsa-miR-124* hsa-miR-194* hsa-miR-607 hsa-miR-3653 hsa-miR-30d hsa-miR-4275 hsa-miR-30a hsa-miR-1243
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MARCH3
    OriGene shRNA RFP: MARCH3
    OriGene siRNA: MARCH3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARCH3
    Clone
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MARCH3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARCH3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARCH3

    Additional cDNA sequence: 

    AF055007.1 AK000103.1 AK290129.1 BC047569.1 BC146948.1 BC146964.1 

    7 DOTS entries:

    DT.312594  DT.311012  DT.97842964  DT.91749833  DT.99926902  DT.120883567  DT.120883621 

    24/85 AceView cDNA sequences (see all 85):

    AI347342 BG200932 CA306167 BU735044 BQ014016 BQ641458 AI215020 AI918773 
    AI376818 BE408696 BF063553 BM790732 CA444753 AV707675 BM727738 BE514584 
    CD674715 BM682935 CK820969 AI203073 BM696411 AI492023 AW051764 BM931562 

    GeneLoc Exon Structure


    Expression
    for MARCH3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MARCH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTATTTAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MARCH3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Primordial germ cell-like cells (Reconstitution of mo...)
    Matrigel embedded cells (Derivation of cardio...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MARCH3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MARCH3

    SOURCE GeneReport for Unigene cluster: Hs.132441
        SABiosciences Expression via Pathway-Focused PCR Array including MARCH3: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH3

    Orthologs
    for MARCH3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MARCH3 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia March31 , 5 membrane-associated ring finger (C3HC4) 31, 5 90.94(n)1
    93.09(a)1    		   18 (30.92 cM)5
    3202531  NM_177115.21  NP_796089.11 
     567617165 
    chicken
    (Gallus gallus)    		 Aves MARCH31 membrane-associated ring finger (C3HC4) 3 85.53(n)
    95.28(a)    		   768965  XM_001232134.2  XP_001232135.2 
    lizard
    (Anolis carolinensis)    		 Reptilia MARCH36
    		 --
    		 96(a)
    		 1 ↔ 1
    		 2(29349568-29393299)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1587856
    		 zgc:158785
    		 48(a)
    		 1 ↔ 1
    		 7(13627027-13641567)
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 40(a)
    		 1 → many
    		 GroupUn.825(13628-16412)
    worm
    (Caenorhabditis elegans)    		 Secernentea F58E6.126
    C17E4.36
    		 Protein C17E4.3
    		 17(a)
    13(a)
    		 possible ortholog
    many → 1
    		 V(9739641-9740845)
    I(9416696-9418869)


    ENSEMBL Gene Tree for MARCH3 (if available)
    TreeFam Gene Tree for MARCH3 (if available) 

    Paralogs
    for MARCH3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MARCH3 gene
    MARCH82  MARCH112  MARCH12  MARCH42  MARCH22  MARCH92  
    4 SIMAP similar genes for MARCH3 using alignment to 2 protein entries:     MARH3_HUMAN (see all proteins):
    MARCH2    MARCH1    MARCH6    MARCH8

    MARCH3 for paralogs           About GeneDecksing



    Genomic Variants
    for MARCH3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2523 NCBI SNPs in MARCH3 are shown (see all 2523)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1447005311,2
    		--126203319(+) CTATGA/GCTACA 1 -- int10--------
    rs35331,2
    		C,F,A,H,--126203506(+) GATGCC/TCTGTG 1 -- ut3136Minor allele frequency- N:0.00EA MN NA NS WA CSA 4820
    rs779387491,2
    		F,--126203690(+) TTTTTT/AAAAAA 1 -- ut313Minor allele frequency- A:0.04WA NA EA 358
    rs1156008991,2
    		F,--126203978(+) TGATGG/AAGATC 1 -- ut311Minor allele frequency- A:0.02WA 118
    rs1385758031,2
    		--126204101(+) ATCTTG/TGACTC 1 -- ut310--------
    rs1886442581,2
    		--126204156(+) TGTGGC/TACAGG 1 -- ut310--------
    rs1125191021,2
    		C,F,--126204161(+) CACAGG/ACACAG 1 -- ut313Minor allele frequency- A:0.04NA 124
    rs1813076291,2
    		--126204166(+) GCACAA/GTTTTA 1 -- ut310--------
    rs2007053611,2
    		--126204215(+) GGCCT-/GGGACC 1 -- ut310--------
    rs1851355981,2
    		--126204268(+) ATGGCA/GGGAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MARCH3 (126203406 - 126366500 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MARCH3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MARCH3
    DNA2.0 Custom Variant and Variant Library Synthesis for MARCH3

    Disorders / Diseases
    for MARCH3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MARCH3 for disorders           About MalaCards

    MARCH3 for disorders           About GeneDecksing

    OMIM gene information: 613333    OMIM disorders: --


    Export disorders for MARCH3 gene to outside databases

    Publications
    for MARCH3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MARCH3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MARCH3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. MARCH-III is a novel component of endosomes with properties similar to those of MARCH-II. (PubMed id 16428329)1, 2 Fukuda H.... Hirose S. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PubMed id 14722266)1, 3 Bartee E.... Frueh K. (2004)
    4. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
    5. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)

    External Searches for MARCH3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing MARCH3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 115123 HGNC: 28728 AceView: MARCH-III Ensembl:ENSG00000173926 euGenes: HUgn115123
    ECgene: MARCH3 H-InvDB: MARCH3

    Other Databases showing MARCH3 gene

    (According to HUGE)
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    Specialized Databases showing MARCH3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MARCH3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MARCH3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MARCH3 gene:
    Search GeneIP for patents involving MARCH3

    GeneCards and IP:
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