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Aliases for MARCH2 Gene

Aliases for MARCH2 Gene

  • Membrane Associated Ring-CH-Type Finger 2 2 3 5
  • Membrane-Associated Ring Finger (C3HC4) 2, E3 Ubiquitin Protein Ligase 2 3
  • Membrane-Associated RING Finger Protein 2 3 4
  • Membrane-Associated RING-CH Protein II 3 4
  • RING Finger Protein 172 3 4
  • MARCH-II 3 4
  • RNF172 3 4
  • Membrane-Associated Ring Finger (C3HC4) 2 2
  • Membrane Associated Ring Finger 2 3
  • EC 6.3.2.- 4
  • EC 6.3.2 63
  • HSPC240 3

External Ids for MARCH2 Gene

Previous GeneCards Identifiers for MARCH2 Gene

  • GC19P008391
  • GC19P008478
  • GC19P008132

Summaries for MARCH2 Gene

Entrez Gene Summary for MARCH2 Gene

  • MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010]

GeneCards Summary for MARCH2 Gene

MARCH2 (Membrane Associated Ring-CH-Type Finger 2) is a Protein Coding gene. Diseases associated with MARCH2 include rubeosis iridis. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is MARCH6.

UniProtKB/Swiss-Prot for MARCH2 Gene

  • E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.

Gene Wiki entry for MARCH2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH2 Gene

Genomics for MARCH2 Gene

Regulatory Elements for MARCH2 Gene

Promoters for MARCH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MARCH2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MARCH2 Gene

Chromosome:
19
Start:
8,413,270 bp from pter
End:
8,439,017 bp from pter
Size:
25,748 bases
Orientation:
Plus strand

Genomic View for MARCH2 Gene

Genes around MARCH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH2 Gene

Proteins for MARCH2 Gene

  • Protein details for MARCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0N8-MARH2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MARCH2
    Protein Accession:
    Q9P0N8
    Secondary Accessions:
    • A6NP10
    • Q5H785
    • Q8N5A3
    • Q96B78

    Protein attributes for MARCH2 Gene

    Size:
    246 amino acids
    Molecular mass:
    26995 Da
    Quaternary structure:
    • Interacts with STX6 (By similarity). Interacts with MARCH3.

    Alternative splice isoforms for MARCH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARCH2 Gene

Proteomics data for MARCH2 Gene at MOPED

Post-translational modifications for MARCH2 Gene

No Post-translational modifications

Domains & Families for MARCH2 Gene

Protein Domains for MARCH2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P0N8

UniProtKB/Swiss-Prot:

MARH2_HUMAN :
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
  • Contains 1 RING-CH-type zinc finger.
Domain:
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
Similarity:
  • Contains 1 RING-CH-type zinc finger.
genes like me logo Genes that share domains with MARCH2: view

No data available for Suggested Antigen Peptide Sequences for MARCH2 Gene

Function for MARCH2 Gene

Molecular function for MARCH2 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.

Enzyme Numbers (IUBMB) for MARCH2 Gene

Gene Ontology (GO) - Molecular Function for MARCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with MARCH2: view
genes like me logo Genes that share phenotypes with MARCH2: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MARCH2 Gene

Localization for MARCH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCH2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MARCH2 Gene COMPARTMENTS Subcellular localization image for MARCH2 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 4
lysosome 3
plasma membrane 3
vacuole 3
cytosol 2

Gene Ontology (GO) - Cellular Components for MARCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IEA --
GO:0005783 endoplasmic reticulum IDA 14722266
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MARCH2: view

Pathways & Interactions for MARCH2 Gene

SuperPathways for MARCH2 Gene

No Data Available

UniProtKB/Swiss-Prot Q9P0N8-MARH2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MARCH2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MARCH2 Gene

Drugs & Compounds for MARCH2 Gene

(3) Drugs for MARCH2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for MARCH2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with MARCH2: view

Transcripts for MARCH2 Gene

Unigene Clusters for MARCH2 Gene

Membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for MARCH2 Gene

GeneLoc Exon Structure for
MARCH2
ECgene alternative splicing isoforms for
MARCH2

Expression for MARCH2 Gene

mRNA expression in normal human tissues for MARCH2 Gene

mRNA differential expression in normal tissues according to GTEx for MARCH2 Gene

This gene is overexpressed in Whole Blood (x5.1).

SOURCE GeneReport for Unigene cluster for MARCH2 Gene Hs.631861

mRNA Expression by UniProt/SwissProt for MARCH2 Gene

Q9P0N8-MARH2_HUMAN
Tissue specificity: Broadly expressed.
genes like me logo Genes that share expression patterns with MARCH2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MARCH2 Gene

Orthologs for MARCH2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MARCH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARCH2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MARCH2 36
  • 93 (a)
OneToOne
MARCH2 35
  • 89.39 (n)
  • 93.47 (a)
dog
(Canis familiaris)
Mammalia MARCH2 35
  • 90.24 (n)
  • 95.53 (a)
MARCH2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia March2 16
March2 35
  • 84.69 (n)
  • 94.72 (a)
March2 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MARCH2 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MARCH2 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia March2 35
  • 86.04 (n)
  • 95.53 (a)
chicken
(Gallus gallus)
Aves MARCH2 35
  • 76.15 (n)
  • 80.49 (a)
MARCH2 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia march2 35
  • 69.92 (n)
  • 78.46 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4783 35
zebrafish
(Danio rerio)
Actinopterygii march2 36
  • 77 (a)
OneToOne
march2 35
  • 74.8 (n)
  • 78.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13442 36
  • 13 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea marc-3 36
  • 14 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSM4 36
  • 4 (a)
OneToMany
Species with no ortholog for MARCH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARCH2 Gene

ENSEMBL:
Gene Tree for MARCH2 (if available)
TreeFam:
Gene Tree for MARCH2 (if available)

Paralogs for MARCH2 Gene

Paralogs for MARCH2 Gene

(1) SIMAP similar genes for MARCH2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MARCH2: view

Variants for MARCH2 Gene

Sequence variations from dbSNP and Humsavar for MARCH2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1133893 - 8,422,000(-) CAAGG(C/G/T)ACGGA reference, missense
rs34099346 - 8,438,461(-) CCTCC(C/G/T)GGATC reference, missense
rs1055546 -- 8,438,909(-) GTGCA(A/G)AGAAG utr-variant-3-prime
rs1055551 -- 8,438,833(-) GCCCA(A/G)AAGGT utr-variant-3-prime
rs1055554 -- 8,438,737(-) AAAAA(A/C)AAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MARCH2 Gene

Variant ID Type Subtype PubMed ID
dgv3719n71 CNV Loss 21882294
nsv911001 CNV Loss 21882294
nsv911003 CNV Loss 21882294
nsv911004 CNV Loss 21882294
nsv911005 CNV Loss 21882294
nsv513514 CNV Insertion 21212237

Variation tolerance for MARCH2 Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MARCH2 Gene

HapMap Linkage Disequilibrium report
MARCH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH2 Gene

Disorders for MARCH2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MARCH2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
rubeosis iridis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MARCH2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MARCH2
genes like me logo Genes that share disorders with MARCH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARCH2 Gene

Publications for MARCH2 Gene

  1. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E. … Frueh K. (J. Virol. 2004) 2 3 4 67
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Ubiquitination and degradation of CFTR by the E3 ubiquitin ligase MARCH2 through its association with adaptor proteins CAL and STX6. (PMID: 23818989) Cheng J. … Guggino W. (PLoS ONE 2013) 3
  5. MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound I^(2)-adrenergic receptors. (PMID: 23166351) Han S.O. … Shenoy S.K. (J. Cell Biol. 2012) 3

Products for MARCH2 Gene

Sources for MARCH2 Gene

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