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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MARCH2 Gene

protein-coding GIFtS: 45
GCID: GC19P008478

membrane-associated ring finger (C3HC4) 2, E3 ubiquitin...

(Previous name: membrane-associated ring finger (C3HC4) 2 )

Search for MARCH2
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Membrane-Associated Ring Finger (C3HC4) 2, E3 Ubiquitin Protein Ligase¹ ²		HSPC240¹
MARCH-II¹ ² ³		Membrane-Associated Ring Finger (C3HC4) 2¹
RNF172¹ ² ³		E3 Ubiquitin-Protein Ligase MARCH2²
Membrane-Associated RING Finger Protein 2² ³		EC 6.3.2.-³
Membrane-Associated RING-CH Protein II² ³		EC 6.3.2⁸
RING Finger Protein 172² ³

External Ids:	HGNC: 28038¹	Entrez Gene: 51257²	Ensembl: ENSG00000099785⁷	OMIM: 613332⁵	UniProtKB: Q9P0N8³

Export aliases for MARCH2 gene to outside databases

Previous GC identifers: GC19P008391 GC19P008132

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MARCH2:

MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add

ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport

between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate

early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 (PubMed 14722266); Nakamura et al., 2005

(PubMed 15689499)).(supplied by OMIM, Mar 2010)

UniProtKB/Swiss-Prot: MARH2_HUMAN, Q9P0N8

Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent

endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2

ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted

substrates. May be involved in endosomal trafficking through interaction with STX6

Gene Wiki entry for MARCH2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_077812.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MARCH2 gene promoter:
RFX1 Pax-5 HTF p300 CUTL1 Nkx2-5 NF-Y ATF CBF(2) En-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for MARCH2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARCH2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2

MARCH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCH2 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P008478: view genomic region (about GC identifiers)

Start:	8,478,187 bp from pter	End:	8,503,901 bp from pter
Size:	25,715 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MARH2_HUMAN, Q9P0N8 (See protein sequence)

Recommended Name: E3 ubiquitin-protein ligase MARCH2

Size: 246 amino acids; 26995 Da

Subunit: Interacts with STX6 (By similarity). Interacts with MARCH3

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass

membrane protein. Endosome membrane; Multi-pass membrane protein (By similarity)

Secondary accessions: A6NP10 Q5H785 Q8N5A3 Q96B78

Alternative splicing: 2 isoforms: Q9P0N8-1 Q9P0N8-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MARCH2: NX_Q9P0N8

4/11 DME Specific Peptides for MARCH2 (Q9P0N8) (see all 11)

CRICHEG

RPRPLTEWL

DGRLLSTVI

TEWLKDPGPR

MARCH2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001005415.1 NP_001005416.1 NP_057580.3

ENSEMBL proteins:

ENSP00000377518 ENSP00000215555 ENSP00000370423

Human Recombinant Protein Products:

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	OriGene Purified Proteins (see all 2): MARCH2 OriGene Protein Over-expression Lysate (see all 3): MARCH2 OriGene Custom Protein Services for MARCH2
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	Novus Biologicals MARCH2 Proteins Novus Biologicals MARCH2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005765	lysosomal membrane	IEA	--
GO:0005783	endoplasmic reticulum	IDA	14722266
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0010008	endosome membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

MARCH2 for ontologies About GeneDecksing

MARCH2 Antibody Products:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MARCH2 for domains About GeneDecksing

2 InterPro domains/families:

IPR013083 Znf_RING/FYVE/PHD

IPR011016 Znf_RING-CH

Graphical View of Domain Structure for InterPro Entry Q9P0N8

ProtoNet protein and cluster: Q9P0N8

2 Blocks protein families:

IPB001841 Zn-finger

IPB011016 RINGv

UniProtKB/Swiss-Prot: MARH2_HUMAN, Q9P0N8

Domain: The RING-CH-type zinc finger domain is required for E3 ligase activity

Similarity: Contains 1 RING-CH-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MARH2_HUMAN, Q9P0N8

Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent

endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2

ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted

substrates. May be involved in endosomal trafficking through interaction with STX6

Enzyme Numbers (IUBMB): EC 6.3.2.-¹ EC 6.3.2²

miRNA Products:		OriGene 3'-UTR Clone (see all 3): MARCH2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARCH2
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate MARCH2:
		hsa-miR-142-5p hsa-miR-891b hsa-miR-3127-5p hsa-miR-340 hsa-miR-664
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MARCH2 OriGene shRNA RFP: MARCH2 OriGene siRNA: MARCH2
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MARCH2

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MARCH2
		Search LifeMap BioReagents cell lines for MARCH2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IDA	14722266
GO:0008270	zinc ion binding	IEA	--

MARCH2 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for MARCH2:

Decreased Wnt reporter activit

Decreased viability of wild-ty

Increased G1 DNA content

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

UniProtKB/Swiss-Prot: MARH2_HUMAN, Q9P0N8

Pathway: Protein modification; protein ubiquitination

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MARCH2

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for MARCH2 (Q9P0N8³ ENSP00000215555⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DLG1	Q12959³, ENSP00000345731⁴	I2D: score=1 STRING: ENSP00000345731
STX6	O43752³, ENSP00000258301⁴	I2D: score=2 STRING: ENSP00000258301
UBE2H	P62256³, ENSP00000347836⁴	I2D: score=2 STRING: ENSP00000347836
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006897	endocytosis	IEA	--
GO:0016567	protein ubiquitination	IDA	14722266

MARCH2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MARCH2

4 HMDB Compounds for MARCH2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--

Search CenterWatch for drugs/clinical trials and news about MARCH2 / MARH2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MARCH2 gene (3 alternative transcripts):

NM_001005415.1 NM_001005416.1 NM_016496.4

Unigene Cluster for MARCH2:

Membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase

Hs.631861 [show with all ESTs]

Unigene Representative Sequence: BC032624

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000393944(uc002mjv.3) ENST00000215555(uc002mjw.3) ENST00000381035(uc002mjx.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): MARCH2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MARCH2
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate MARCH2:
		hsa-miR-142-5p hsa-miR-891b hsa-miR-3127-5p hsa-miR-340 hsa-miR-664
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MARCH2 OriGene shRNA RFP: MARCH2 OriGene siRNA: MARCH2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARCH2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MARCH2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MARCH2 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARCH2

Additional cDNA sequence:

AB197929.1 AF151074.1 AK130163.1 BC015910.1 BC032624.1 BC111388.1

7 DOTS entries:

DT.108132 DT.100811450 DT.92421587 DT.100811449 DT.438268 DT.87010044 DT.95268219

24/84 AceView cDNA sequences (see all 84):

BM919359 AI198308 AW134783 AI093223 BE467905 BI193168 BQ059396 AW206208

BV174776 BE671273 BG180936 BX283700 BQ894513 BG705726 AI668895 AI969222

AW300768 BX420869 AI924789 AK130163 BQ015507 AI277491 AF151074 BQ575119

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for MARCH2 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b
SP1:
SP2:							-

ECgene alternative splicing isoforms for MARCH2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MARCH2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCACCTTCTG

About this image

MARCH2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Mandibular Process

Bone

Thoracic Rib

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Intermediate limb mesenchymal cells (ILM cells) (Primary Cell)

Bone, Cartilage, Limb

See MARCH2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MARCH2

SOURCE GeneReport for Unigene cluster: Hs.631861

UniProtKB/Swiss-Prot: MARH2_HUMAN, Q9P0N8

Tissue specificity: Broadly expressed

SABiosciences Expression via Pathway-Focused PCR Array including MARCH2:

Ubiquitin Ligases in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARCH2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MARCH2 gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MARCH2¹	membrane-associated ring finger (C3HC4) 2	76.15(n) 80.49(a)		420062 XM_418182.2 XP_418182.2
zebrafish (Danio rerio)	Actinopterygii	march2¹	membrane-associated ring finger (C3HC4) 2	74.8(n) 78.05(a)		555611 NM_001044790.2 NP_001038255.2
honey bee (Apis mellifera)	Insecta	--	--	37(a)	1 → many	GroupUn.825(13628-16412)
worm (Caenorhabditis elegans)	Secernentea	F58E6.12⁶ C17E4.3⁶	Protein C17E4.3	16(a) 11(a)	possible ortholog 1 ↔ many	V(9739641-9740845) I(9416696-9418869)

ENSEMBL Gene Tree for MARCH2 (if available)
TreeFam Gene Tree for MARCH2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MARCH2 gene

MARCH8² MARCH3² MARCH11² MARCH1² MARCH4² MARCH9²

1 SIMAP similar gene for MARCH2 using alignment to 5 protein entries: MARH2_HUMAN (see all proteins):

MARCH3

MARCH2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11667516^1,2	C,F,H,	--	8476316(+)	`CCTGCC/TACAAA`	3	--	us2k¹		14		NS EA NA WA	1966
rs11667277^1,2	C,F,H,	--	8476358(+)	`gcaatG/Agaagg`	3	--	us2k¹ tfbs³		1		NA	120
rs8108388^1,2	A	--	8476490(+)	`atgctG/Tgatcc`	3	--	us2k¹		0	--	--	--	--
rs8108500^1,2	A	--	8476567(+)	`agtggC/Tgaggt`	3	--	us2k¹		0	--	--	--	--
rs112418983^1,2		--	8476583(+)	`CTCACT/AGCAGC`	3	--	us2k¹		3		CSA WA	121
rs8104101^1,2	C,F,A,H,	--	8476587(+)	`CTGCAA/GCCCAG`	3	--	us2k¹ tfbs³		12		NA WA CSA EA	375
rs34169349^1,2	C,F,	--	8476611(+)	`AATTGA/GTCCTC`	3	--	us2k¹		4		NA CSA	8
rs113964336^1,2	C,	--	8476784(+)	`GGATTG/ACAGAC`	3	--	us2k¹		3		NA WA	240
rs62117520^1,2	F,	--	8476807(+)	`GCCTGG/ACCTGG`	3	--	us2k¹		2		WA NA	238
rs6603068^1,2	C,F,H,	--	8476849(+)	`CTTTTT/CTTTTC`	3	--	us2k¹ trp³		12		NS NA WA CSA	800

HapMap Linkage Disequilibrium report for MARCH2 (8478187 - 8503901 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MARCH2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MARCH2

DNA2.0 Custom Variant and Variant Library Synthesis for MARCH2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MARCH2 for disorders About MalaCards

MARCH2 for disorders About GeneDecksing

OMIM gene information: 613332 OMIM disorders: --

Export disorders for MARCH2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MARCH2 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with MARCH2)

Utopia: connect your pdf to the dynamic
world of online information

Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PubMed id 14722266)^{1, 2, 3} Bartee E.... Frueh K. (2004)
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{1, 2, 3} Zhang Q.-H.... Chen Z. (2000)
MARCH-III is a novel component of endosomes with properties similar to those of MARCH-II. (PubMed id 16428329)^{1, 2} Fukuda H.... Hirose S. (2006)
MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking. (PubMed id 15689499)^{1, 2} Nakamura N.... Hirose S. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
MARCH2 promotes endocytosis and lysosomal sorting of c arvedilol-bound b(2)-adrenergic receptors. (PubMed id 23166351)¹ Han S.O....Shenoy S.K. (2012)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact. (PubMed id 17980554)¹ Cao Z....Xavier R.J. (2008)
Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PubMed id 17192395)¹ Macaulay I.C....Ouwehand W.H. (2007)
A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)¹ Girard A....Carmell M.A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51257	HGNC: 28038	AceView: MARCH-II	Ensembl:ENSG00000099785	euGenes: HUgn51257
ECgene: MARCH2	H-InvDB: MARCH2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MARCH2	Pharmacogenomics, SNPs, Pathways

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