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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MARCH2 Gene

protein-coding   GIFtS: 48
GCID: GC19P008478

Membrane-Associated Ring Finger (C3HC4) 2, E3 Ubiquitin...

(Previous name: membrane-associated ring finger (C3HC4) 2)
Microbiology & Infectious Diseases Congress
  Search for MARCH2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Membrane-Associated Ring Finger (C3HC4) 2, E3 Ubiquitin Protein
Ligase1 2
     RING Finger Protein 1722 3
Membrane-Associated RING Finger Protein 22 3     Membrane-Associated Ring Finger (C3HC4) 21
Membrane-Associated RING-CH Protein II2 3     E3 Ubiquitin-Protein Ligase MARCH22
MARCH-II2 3     EC 6.3.2.-3
RNF1722 3     EC 6.3.28

External Ids:    HGNC: 280381   Entrez Gene: 512572   Ensembl: ENSG000000997857   OMIM: 6133325   UniProtKB: Q9P0N83   

Export aliases for MARCH2 gene to outside databases

Previous GC identifers: GC19P008391 GC19P008132


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MARCH2 Gene:
MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add
ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport
between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to
regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 (PubMed 14722266); Nakamura
et al., 2005 (PubMed 15689499)).(supplied by OMIM, Mar 2010)

GeneCards Summary for MARCH2 Gene: 
MARCH2 (membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity and zinc ion binding. An important paralog of this gene is MARCH8.

UniProtKB/Swiss-Prot: MARH2_HUMAN, Q9P0N8
Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their
subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin
from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to
targeted substrates. May be involved in endosomal trafficking through interaction with STX6

Gene Wiki entry for MARCH2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_077812.2  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MARCH2 gene promoter:
         RFX1   Pax-5   HTF   p300   CUTL1   Nkx2-5   NF-Y   ATF   CBF(2)   En-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MARCH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARCH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

MARCH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCH2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P008478:  view genomic region     (about GC identifiers)

Start:
8,478,154 bp from pter      End:
8,503,901 bp from pter
Size:
25,748 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MARH2_HUMAN, Q9P0N8 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MARCH2  
Size: 246 amino acids; 26995 Da
Subunit: Interacts with STX6 (By similarity). Interacts with MARCH3
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass
membrane protein. Endosome membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: A6NP10 Q5H785 Q8N5A3 Q96B78
Alternative splicing: 2 isoforms:  Q9P0N8-1   Q9P0N8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MARCH2: NX_Q9P0N8

Explore proteomics data for MARCH2 at MOPED 

4/11 DME Specific Peptides for MARCH2 (Q9P0N8) (see all 11)
 CRICHEG  RPRPLTEWL  DGRLLSTVI  TEWLKDPGPR 

MARCH2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

MARCH2 Protein Expression
REFSEQ proteins (3 alternative transcripts): 
NP_001005415.1  NP_001005416.1  NP_057580.3  

ENSEMBL proteins: 
 ENSP00000370423   ENSP00000472027   ENSP00000471619   ENSP00000469386   ENSP00000471411  
 ENSP00000471536   ENSP00000377518   ENSP00000215555  

Human Recombinant Protein Products for MARCH2: 
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Novus Biologicals MARCH2 Proteins
Novus Biologicals MARCH2 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005765lysosomal membrane IEA--
GO:0005783endoplasmic reticulum IDA14722266
GO:0005789endoplasmic reticulum membrane IEA--
GO:0010008endosome membrane IEA--
GO:0016021integral to membrane IEA--

MARCH2 for ontologies           About GeneDecksing



MARCH2 Antibody Products: 
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
RNF: RING-type (C3HC4) zinc fingers
MARCH: MARCH membrane-associated ring fingers

2 InterPro protein domains:
 IPR013083 Znf_RING/FYVE/PHD
 IPR011016 Znf_RING-CH

Graphical View of Domain Structure for InterPro Entry Q9P0N8

ProtoNet protein and cluster: Q9P0N8

2 Blocks protein domains:
IPB001841 Zn-finger
IPB011016 RINGv


UniProtKB/Swiss-Prot: MARH2_HUMAN, Q9P0N8
Domain: The RING-CH-type zinc finger domain is required for E3 ligase activity
Similarity: Contains 1 RING-CH-type zinc finger


MARCH2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: MARH2_HUMAN, Q9P0N8
Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their
subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin
from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to
targeted substrates. May be involved in endosomal trafficking through interaction with STX6

     Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004842ubiquitin-protein ligase activity IDA14722266
GO:0005515protein binding ----
GO:0008270zinc ion binding IEA--
GO:0046872metal ion binding ----
     
MARCH2 for ontologies           About GeneDecksing


Phenotypes:
     3 GenomeRNAi human phenotypes for MARCH2:
 Decreased Wnt reporter activit  Decreased viability of wild-ty  Increased G1 DNA content 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for MARCH2 
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARCH2 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARCH2 

miRNA
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Browse SwitchGear 3'UTR luciferase reporter plasmids
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH2


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



UniProtKB/Swiss-Prot: MARH2_HUMAN, Q9P0N8
Pathway: Protein modification; protein ubiquitination

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MARCH2

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for MARCH2 (Q9P0N83 ENSP000002155554) via UniProtKB, MINT, STRING, and/or I2D

InteractantInteraction Details
GeneCardExternal ID(s)
DLG1Q129593, ENSP000003457314I2D: score=1 STRING: ENSP00000345731
STX6O437523, ENSP000002583014I2D: score=2 STRING: ENSP00000258301
UBE2HP622563, ENSP000003478364I2D: score=2 STRING: ENSP00000347836
ELAVL1ENSP000003852694STRING: ENSP00000385269
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006897endocytosis IEA--
GO:0016567protein ubiquitination IDA14722266

MARCH2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for MARCH2 (MARH2)

4 HMDB Compounds for MARCH2    About this table
CompoundSynonyms CAS #PubMed Ids
Adenosine monophosphate5'-AMP (see all 28)61-19-8--
Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

Search CenterWatch for drugs/clinical trials and news about MARCH2 / MARH2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MARCH2 gene (3 alternative transcripts): 
NM_001005415.1  NM_001005416.1  NM_016496.4  

Unigene Cluster for MARCH2:

Membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
Hs.631861  [show with all ESTs]
Unigene Representative Sequence: BC032624
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000381035(uc002mjx.3) ENST00000595142 ENST00000601724 ENST00000601283
ENST00000595213 ENST00000602117 ENST00000594796 ENST00000393944(uc002mjv.3)
ENST00000215555(uc002mjw.3)
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
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5 QIAGEN miScript miRNA Assays for microRNAs that regulate MARCH2:
hsa-miR-142-5p hsa-miR-891b hsa-miR-3127-5p hsa-miR-340 hsa-miR-664
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
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Additional mRNA sequence: 

AB197929.1 AF151074.1 AK130163.1 BC015910.1 BC032624.1 BC111388.1 

7 DOTS entries:

DT.108132  DT.100811450  DT.92421587  DT.100811449  DT.438268  DT.87010044  DT.95268219 

24/84 AceView cDNA sequences (see all 84):

BQ059396 AI093223 BM919359 BE671273 BE467905 BG180936 AI198308 AW206208 
BV174776 BI193168 AW134783 BM726110 BQ575119 CF145960 AF070529 BC032624 
BX420869 AI668895 BQ894513 AI969222 NM_016496 BQ016196 BG705726 AA928091 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for MARCH2    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:                                    
SP2:                    -               


ECgene alternative splicing isoforms for MARCH2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MARCH2 expression in normal human tissues (normalized intensities)      MARCH2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCACCTTCTG
MARCH2 Expression
About this image


MARCH2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/40 selected tissues (see all 40) fully expand
 
 Epithelium
         vagina ; squamous epithelial cells   
 
 Uterus
         uterus, post-menopause ; glandular cells   
 
 Testis (Reproductive System)    fully expand to see all 4 entries
         Leydig Cells Testis Interstitium
         seminal vesicle ; glandular cells   
 
 Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
         colon ; peripheral nerve/ganglion   
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Cerebral Cortex

See MARCH2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MARCH2

SOURCE GeneReport for Unigene cluster: Hs.631861

UniProtKB/Swiss-Prot: MARH2_HUMAN, Q9P0N8
Tissue specificity: Broadly expressed

    SABiosciences Expression via Pathway-Focused PCR Array including MARCH2: 
          Ubiquitin Ligases in human mouse rat

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MARCH2 gene from 4/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia March21 , 5 membrane-associated ring finger (C3HC4) 21, 5 84.69(n)1
94.72(a)1
  17 (17.98 cM)5
2247031  NM_001252480.11  NP_001239409.11 
 336856925 
chicken
(Gallus gallus)
Aves MARCH21 membrane-associated ring finger (C3HC4) 2 76.15(n)
80.49(a)
  420062  XM_418182.2  XP_418182.2 
zebrafish
(Danio rerio)
Actinopterygii march21 membrane-associated ring finger (C3HC4) 2 74.8(n)
78.05(a)
  555611  NM_001044790.2  NP_001038255.2 
worm
(Caenorhabditis elegans)
Secernentea C17E4.36
Protein C17E4.3
10(a)
1 → many
I(9416703-9418876)


ENSEMBL Gene Tree for MARCH2 (if available)
TreeFam Gene Tree for MARCH2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MARCH2 gene
MARCH82  MARCH62  MARCH32  MARCH12  
1 SIMAP similar gene for MARCH2 using alignment to 5 protein entries:     MARH2_HUMAN (see all proteins):
MARCH3

MARCH2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/662 SNPs in MARCH2 are shown (see all 662)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs355188661,2
C--8148373(+) AATAC-/A/AA  
        
AAAAA
3 -- int11NA 2
rs116675161,2
C,F,H--8476316(+) CCTGCC/TACAAA 3 -- us2k114Minor allele frequency- T:0.08NS EA NA WA 1966
rs116672771,2
C,F,H--8476358(+) gcaatG/Agaagg 3 -- us2k1 tfbs31Minor allele frequency- A:0.02NA 120
rs81083881,2
A--8476490(+) atgctG/Tgatcc 3 -- us2k10--------
rs81085001,2
A--8476567(+) agtggC/Tgaggt 3 -- us2k10--------
rs1124189831,2
F--8476583(+) CTCACT/AGCAGC 3 -- us2k13Minor allele frequency- A:0.05CSA WA 121
rs81041011,2
C,F,A,H--8476587(+) ctgcaA/Gcccag 3 -- us2k1 tfbs312Minor allele frequency- G:0.37NA WA CSA EA 375
rs341693491,2
C,F--8476611(+) AATTGA/GTCCTC 3 -- us2k14Minor allele frequency- G:0.38NA CSA 8
rs1139643361,2
C,F--8476784(+) GGATTG/ACAGAC 3 -- us2k13Minor allele frequency- A:0.13NA WA 240
rs621175201,2
C,F--8476807(+) GCCTGG/ACCTGG 3 -- us2k12Minor allele frequency- A:0.07WA NA 238

HapMap Linkage Disequilibrium report for MARCH2 (8478154 - 8503901 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for MARCH2:    About this table     
Variant IDTypeSubtypePubMed ID
nsv513514CNV Insertion21212237
nsv911005CNV Loss21882294
nsv911004CNV Loss21882294
nsv911003CNV Loss21882294
nsv911001CNV Loss21882294
dgv3719n71CNV Loss21882294

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MARCH2 for disorders           About MalaCards
OMIM gene information: 613332    OMIM disorders: --


MARCH2 for disorders           About GeneDecksing


Export disorders for MARCH2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MARCH2 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with MARCH2)
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  1. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PubMed id 14722266)1, 2, 3 Bartee E.... Frueh K. (2004)
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
  3. MARCH-III is a novel component of endosomes with properties similar to those of MARCH-II. (PubMed id 16428329)1, 2 Fukuda H.... Hirose S. (2006)
  4. MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking. (PubMed id 15689499)1, 2 Nakamura N.... Hirose S. (2005)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  6. Ubiquitination and degradation of CFTR by the E3 ubiqu itin ligase MARCH2 through its association with adaptor proteins CAL and STX6. (PubMed id 23818989)1 Cheng J. and Guggino W. (2013)
  7. MARCH2 promotes endocytosis and lysosomal sorting of c arvedilol-bound b(2)-adrenergic receptors. (PubMed id 23166351)1 Han S.O....Shenoy S.K. (2012)
  8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
  9. DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact. (PubMed id 17980554)1 Cao Z....Xavier R.J. (2008)
  10. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PubMed id 17192395)1 Macaulay I.C....Ouwehand W.H. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51257 HGNC: 28038 AceView: MARCH-II Ensembl:ENSG00000099785 euGenes: HUgn51257
ECgene: MARCH2 H-InvDB: MARCH2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MARCH2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MARCH2 gene:
Search GeneIP for patents involving MARCH2

GeneCards and IP:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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