Aliases for MARCH2 Gene
External Ids for MARCH2 Gene
Previous GeneCards Identifiers for MARCH2 Gene
MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 22.214.171.124). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010]
GeneCards Summary for MARCH2 Gene
MARCH2 (Membrane Associated Ring-CH-Type Finger 2) is a Protein Coding gene. Diseases associated with MARCH2 include Extragonadal Nonseminomatous Germ Cell Tumor and Extragonadal Germ Cell Cancer. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is MARCH3.
UniProtKB/Swiss-Prot for MARCH2 Gene
E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.