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Aliases for MARCH2 Gene

Aliases for MARCH2 Gene

  • Membrane Associated Ring-CH-Type Finger 2 2 3 5
  • Membrane-Associated Ring Finger (C3HC4) 2, E3 Ubiquitin Protein Ligase 2 3
  • Membrane-Associated RING Finger Protein 2 3 4
  • RING-Type E3 Ubiquitin Transferase MARCH2 3 4
  • Membrane-Associated RING-CH Protein II 3 4
  • RING Finger Protein 172 3 4
  • MARCH-II 3 4
  • RNF172 3 4
  • Membrane-Associated Ring Finger (C3HC4) 2 2
  • E3 Ubiquitin-Protein Ligase MARCH2 3
  • Membrane Associated Ring Finger 2 3
  • EC 2.3.2.27 4
  • EC 6.3.2 61
  • HSPC240 3

External Ids for MARCH2 Gene

Previous GeneCards Identifiers for MARCH2 Gene

  • GC19P008391
  • GC19P008478
  • GC19P008132

Summaries for MARCH2 Gene

Entrez Gene Summary for MARCH2 Gene

  • MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010]

GeneCards Summary for MARCH2 Gene

MARCH2 (Membrane Associated Ring-CH-Type Finger 2) is a Protein Coding gene. Diseases associated with MARCH2 include Extragonadal Nonseminomatous Germ Cell Tumor and Extragonadal Germ Cell Cancer. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is MARCH3.

UniProtKB/Swiss-Prot for MARCH2 Gene

  • E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.

Gene Wiki entry for MARCH2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH2 Gene

Genomics for MARCH2 Gene

Regulatory Elements for MARCH2 Gene

Enhancers for MARCH2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G008485 1.4 Ensembl ENCODE dbSUPER 38.4 +74.9 74870 4.7 ARNT AGO1 SIN3A ARID4B ZNF2 YY1 KDM4B ZNF263 PAF1 YY2 MARCH2 XAB2 HNRNPM ZNF414 ZNF559 ZNF177 ZNF699 ELAVL1 SNAPC2 PRAM1
GH19G008457 1.3 Ensembl ENCODE 38.5 +46.5 46546 3.8 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A ZNF2 YY1 SLC30A9 MARCH2 PRAM1 ENSG00000279827 GC19P008487
GH19G008444 1.4 Ensembl ENCODE 32.3 +32.9 32912 3.9 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 MARCH2 XAB2 HNRNPM ELAVL1 ZNF558 ZNF699 ZNF414 PRAM1 ENSG00000279827 GC19P008487
GH19G008417 1.3 Ensembl ENCODE 28.4 +4.9 4861 1.9 HDGF PKNOX1 CREB3L1 ARNT FEZF1 ZNF766 CBX5 REST SMARCB1 ZNF592 MARCH2 GC19P008426 PIR43177
GH19G008492 1.2 Ensembl ENCODE dbSUPER 29.3 +81.2 81157 4.0 HDAC1 KLF1 NR2F1 ZMYM3 MAX ZIC2 RARA ZNF121 HDAC2 ZBTB48 MARCH2 PRAM1 GC19P008487
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MARCH2 on UCSC Golden Path with GeneCards custom track

Promoters for MARCH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106827 130 801 HDGF PKNOX1 ARID4B SIN3A ZNF143 FOS SP3 CEBPZ SP5 NFYC

Genomic Location for MARCH2 Gene

Chromosome:
19
Start:
8,413,270 bp from pter
End:
8,439,017 bp from pter
Size:
25,748 bases
Orientation:
Plus strand

Genomic View for MARCH2 Gene

Genes around MARCH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH2 Gene

Proteins for MARCH2 Gene

  • Protein details for MARCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0N8-MARH2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MARCH2
    Protein Accession:
    Q9P0N8
    Secondary Accessions:
    • A6NP10
    • Q5H785
    • Q8N5A3
    • Q96B78

    Protein attributes for MARCH2 Gene

    Size:
    246 amino acids
    Molecular mass:
    26995 Da
    Quaternary structure:
    • Interacts with STX6 (By similarity). Interacts with MARCH3.

    Alternative splice isoforms for MARCH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARCH2 Gene

Selected DME Specific Peptides for MARCH2 Gene

Q9P0N8:
  • WTLVSFRYHC
  • DGRLLSTVI
  • WLSSSNTSYCELCH
  • VCFLFITPLA
  • ISGWLCLRGA
  • CCHLPGSLCDC
  • GTLGAVHKSCLE
  • TEWLKDPGPR
  • RPRPLTEWL
  • CRICHEG
  • LEAVGLIALT

Post-translational modifications for MARCH2 Gene

No Post-translational modifications

Domains & Families for MARCH2 Gene

Protein Domains for MARCH2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P0N8

UniProtKB/Swiss-Prot:

MARH2_HUMAN :
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
Domain:
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
genes like me logo Genes that share domains with MARCH2: view

No data available for Suggested Antigen Peptide Sequences for MARCH2 Gene

Function for MARCH2 Gene

Molecular function for MARCH2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.

Enzyme Numbers (IUBMB) for MARCH2 Gene

Gene Ontology (GO) - Molecular Function for MARCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 14722266
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MARCH2: view
genes like me logo Genes that share phenotypes with MARCH2: view

Animal Model Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MARCH2 Gene

Localization for MARCH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCH2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARCH2 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 4
plasma membrane 3
lysosome 3
cytosol 2

Gene Ontology (GO) - Cellular Components for MARCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome IEA --
GO:0005783 endoplasmic reticulum IEA,IDA 14722266
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with MARCH2: view

Pathways & Interactions for MARCH2 Gene

SuperPathways for MARCH2 Gene

No Data Available

UniProtKB/Swiss-Prot Q9P0N8-MARH2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MARCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MARCH2: view

No data available for Pathways by source and SIGNOR curated interactions for MARCH2 Gene

Drugs & Compounds for MARCH2 Gene

(3) Drugs for MARCH2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for MARCH2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with MARCH2: view

Transcripts for MARCH2 Gene

Unigene Clusters for MARCH2 Gene

Membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for MARCH2 Gene

GeneLoc Exon Structure for
MARCH2
ECgene alternative splicing isoforms for
MARCH2

Expression for MARCH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MARCH2 Gene

mRNA differential expression in normal tissues according to GTEx for MARCH2 Gene

This gene is overexpressed in Whole Blood (x5.1).

SOURCE GeneReport for Unigene cluster for MARCH2 Gene:

Hs.631861

mRNA Expression by UniProt/SwissProt for MARCH2 Gene:

Q9P0N8-MARH2_HUMAN
Tissue specificity: Broadly expressed.

Evidence on tissue expression from TISSUES for MARCH2 Gene

  • Nervous system(4.3)
  • Skin(4.2)
  • Blood(4.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with MARCH2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARCH2 Gene

Orthologs for MARCH2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MARCH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARCH2 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MARCH2 35 34
  • 90.24 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MARCH2 34 35
  • 89.39 (n)
rat
(Rattus norvegicus)
Mammalia March2 34
  • 86.04 (n)
mouse
(Mus musculus)
Mammalia March2 16 35 34
  • 84.69 (n)
oppossum
(Monodelphis domestica)
Mammalia MARCH2 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MARCH2 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves MARCH2 35 34
  • 76.15 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia march2 34
  • 69.92 (n)
zebrafish
(Danio rerio)
Actinopterygii march2 35 34
  • 74.8 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4783 34
fruit fly
(Drosophila melanogaster)
Insecta CG13442 35
  • 13 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea marc-3 35
  • 14 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSM4 35
  • 4 (a)
OneToMany
Species where no ortholog for MARCH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARCH2 Gene

ENSEMBL:
Gene Tree for MARCH2 (if available)
TreeFam:
Gene Tree for MARCH2 (if available)

Paralogs for MARCH2 Gene

Paralogs for MARCH2 Gene

(1) SIMAP similar genes for MARCH2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MARCH2: view

Variants for MARCH2 Gene

Sequence variations from dbSNP and Humsavar for MARCH2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000235901 -- 8,419,605(+) AGGTC(A/G)GGAGA intron-variant
rs1000251345 -- 8,419,767(+) GCTGA(C/G)ATCAG intron-variant
rs1000372333 -- 8,424,491(+) TGAAA(C/T)CCCGT intron-variant
rs1000529588 -- 8,427,393(+) CATGC(C/T)CAGCA intron-variant
rs1000554807 -- 8,416,198(+) TTAGC(C/T)GGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH2 Gene

Variant ID Type Subtype PubMed ID
nsv513514 CNV insertion 21212237

Variation tolerance for MARCH2 Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MARCH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MARCH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH2 Gene

Disorders for MARCH2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MARCH2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
extragonadal nonseminomatous germ cell tumor
  • primary malignant extragonadal nonseminoma
extragonadal germ cell cancer
  • extragonadal germ cell malignant tumor
rubeosis iridis
nonseminomatous germ cell tumor
  • non-seminomatous germ-cell tumors
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MARCH2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MARCH2
genes like me logo Genes that share disorders with MARCH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARCH2 Gene

Publications for MARCH2 Gene

  1. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E. … Frueh K. (J. Virol. 2004) 2 3 4 64
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  3. MARCH-III is a novel component of endosomes with properties similar to those of MARCH-II. (PMID: 16428329) Fukuda H. … Hirose S. (J. Biochem. 2006) 3 4 64
  4. MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking. (PMID: 15689499) Nakamura N. … Hirose S. (Mol. Biol. Cell 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for MARCH2 Gene

Sources for MARCH2 Gene

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