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Aliases for MARCH2 Gene

Aliases for MARCH2 Gene

  • Membrane-Associated Ring Finger (C3HC4) 2, E3 Ubiquitin Protein Ligase 2 3
  • Membrane-Associated RING Finger Protein 2 3 4
  • Membrane-Associated RING-CH Protein II 3 4
  • RING Finger Protein 172 3 4
  • MARCH-II 3 4
  • RNF172 3 4
  • Membrane-Associated Ring Finger (C3HC4) 2 2
  • E3 Ubiquitin-Protein Ligase MARCH2 3
  • EC 6.3.2.- 4
  • EC 6.3.2 64
  • HSPC240 3

External Ids for MARCH2 Gene

Summaries for MARCH2 Gene

Entrez Gene Summary for MARCH2 Gene

  • MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010]

GeneCards Summary for MARCH2 Gene

MARCH2 (Membrane-Associated Ring Finger (C3HC4) 2, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is MARCH3.

UniProtKB/Swiss-Prot for MARCH2 Gene

  • E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.

Gene Wiki entry for MARCH2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH2 Gene

Genomics for MARCH2 Gene

Genomic Location for MARCH2 Gene

Start:
8,413,270 bp from pter
End:
8,439,017 bp from pter
Size:
25,748 bases
Orientation:
Plus strand

Genomic View for MARCH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH2 Gene

Regulatory Elements for MARCH2 Gene

Proteins for MARCH2 Gene

  • Protein details for MARCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0N8-MARH2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MARCH2
    Protein Accession:
    Q9P0N8
    Secondary Accessions:
    • A6NP10
    • Q5H785
    • Q8N5A3
    • Q96B78

    Protein attributes for MARCH2 Gene

    Size:
    246 amino acids
    Molecular mass:
    26995 Da
    Quaternary structure:
    • Interacts with STX6 (By similarity). Interacts with MARCH3.

    Alternative splice isoforms for MARCH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARCH2 Gene

Proteomics data for MARCH2 Gene at MOPED

Post-translational modifications for MARCH2 Gene

No Post-translational modifications

Domains for MARCH2 Gene

Gene Families for MARCH2 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • MARCH :MARCH membrane-associated ring fingers

Protein Domains for MARCH2 Gene

UniProtKB/Swiss-Prot:

MARH2_HUMAN
Domain:
  • The RING-CH-type zinc finger domain is required for E3 ligase activity:
    • Q9P0N8
Similarity:
  • Contains 1 RING-CH-type zinc finger.:
    • Q9P0N8
genes like me logo Genes that share domains with MARCH2: view

Function for MARCH2 Gene

Molecular function for MARCH2 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.

Enzyme Numbers (IUBMB) for MARCH2 Gene

Gene Ontology (GO) - Molecular Function for MARCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 14722266
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with MARCH2: view
genes like me logo Genes that share phenotypes with MARCH2: view

miRNA for MARCH2 Gene

miRTarBase miRNAs that target MARCH2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MARCH2 Gene

Localization for MARCH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCH2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MARCH2 Gene COMPARTMENTS Subcellular localization image for MARCH2 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
lysosome 5
vacuole 5
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for MARCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome --
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome --
GO:0005783 endoplasmic reticulum IDA 14722266
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with MARCH2: view

Pathways for MARCH2 Gene

SuperPathways for MARCH2 Gene

No Data Available

UniProtKB/Swiss-Prot Q9P0N8-MARH2_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for MARCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MARCH2: view

No data available for Pathways by source for MARCH2 Gene

Compounds for MARCH2 Gene

(4) HMDB Compounds for MARCH2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with MARCH2: view

Transcripts for MARCH2 Gene

Unigene Clusters for MARCH2 Gene

Membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for MARCH2 Gene

GeneLoc Exon Structure for
MARCH2
ECgene alternative splicing isoforms for
MARCH2

Expression for MARCH2 Gene

mRNA expression in normal human tissues for MARCH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MARCH2 Gene

This gene is overexpressed in Whole Blood (5.1).

SOURCE GeneReport for Unigene cluster for MARCH2 Gene Hs.631861

mRNA Expression by UniProt/SwissProt for MARCH2 Gene

Q9P0N8-MARH2_HUMAN
Tissue specificity: Broadly expressed.
genes like me logo Genes that share expressions with MARCH2: view

Orthologs for MARCH2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MARCH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARCH2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MARCH2 36
  • 89.39 (n)
  • 93.47 (a)
MARCH2 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MARCH2 36
  • 90.24 (n)
  • 95.53 (a)
MARCH2 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia March2 36
  • 84.69 (n)
  • 94.72 (a)
March2 16
March2 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MARCH2 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MARCH2 37
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia March2 36
  • 86.04 (n)
  • 95.53 (a)
chicken
(Gallus gallus)
Aves MARCH2 36
  • 76.15 (n)
  • 80.49 (a)
MARCH2 37
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia march2 36
  • 69.92 (n)
  • 78.46 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4783 36
zebrafish
(Danio rerio)
Actinopterygii march2 36
  • 74.8 (n)
  • 78.05 (a)
march2 37
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13442 37
  • 13 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea marc-3 37
  • 14 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSM4 37
  • 4 (a)
OneToMany
Species with no ortholog for MARCH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARCH2 Gene

ENSEMBL:
Gene Tree for MARCH2 (if available)
TreeFam:
Gene Tree for MARCH2 (if available)

Paralogs for MARCH2 Gene

Paralogs for MARCH2 Gene

Selected SIMAP similar genes for MARCH2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MARCH2: view

Variants for MARCH2 Gene

Sequence variations from dbSNP and Humsavar for MARCH2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs890849 -- 8,413,366(+) GGACC(C/G)GGGCC utr-variant-5-prime, upstream-variant-2KB
rs1055544 -- 8,438,980(-) AGGGK(G/T)GGGTT utr-variant-3-prime
rs1055545 -- 8,438,926(-) GAAAG(G/T)GGGCC utr-variant-3-prime
rs1055546 -- 8,438,909(-) GTGCA(A/G)AGAAG utr-variant-3-prime
rs1055551 -- 8,438,833(-) GCCCA(A/G)AAGGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MARCH2 Gene

Variant ID Type Subtype PubMed ID
dgv3719n71 CNV Loss 21882294
nsv911001 CNV Loss 21882294
nsv911003 CNV Loss 21882294
nsv911004 CNV Loss 21882294
nsv911005 CNV Loss 21882294
nsv513514 CNV Insertion 21212237

Relevant External Links for MARCH2 Gene

HapMap Linkage Disequilibrium report
MARCH2

Disorders for MARCH2 Gene

No disorders were found for MARCH2 Gene.

No data available for UniProtKB/Swiss-Prot for MARCH2 Gene

Publications for MARCH2 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E. … Frueh K. (J. Virol. 2004) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking. (PMID: 15689499) Nakamura N. … Hirose S. (Mol. Biol. Cell 2005) 3 4
  5. MARCH-III is a novel component of endosomes with properties similar to those of MARCH-II. (PMID: 16428329) Fukuda H. … Hirose S. (J. Biochem. 2006) 3 4

Products for MARCH2 Gene

Sources for MARCH2 Gene

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