Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MARCH2 Gene

protein-coding   GIFtS: 48
GCID: GC19P008478

Membrane-Associated Ring Finger (C3HC4) 2, E3 Ubiquitin...

(Previous name: membrane-associated ring finger (C3HC4) 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Membrane-Associated Ring Finger (C3HC4) 2, E3 Ubiquitin Protein
Ligase1 2
     RING Finger Protein 1722 3
Membrane-Associated RING Finger Protein 22 3     Membrane-Associated Ring Finger (C3HC4) 21
Membrane-Associated RING-CH Protein II2 3     E3 Ubiquitin-Protein Ligase MARCH22
MARCH-II2 3     EC 6.3.2.-3
RNF1722 3     EC 6.3.28

External Ids:    HGNC: 280381   Entrez Gene: 512572   Ensembl: ENSG000000997857   OMIM: 6133325   UniProtKB: Q9P0N83   

Export aliases for MARCH2 gene to outside databases

Previous GC identifers: GC19P008391 GC19P008132


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MARCH2 Gene:
MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add
ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport
between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to
regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 (PubMed 14722266); Nakamura
et al., 2005 (PubMed 15689499)).(supplied by OMIM, Mar 2010)

GeneCards Summary for MARCH2 Gene:
MARCH2 (membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with MARCH2 include tonsillitis, and thyroiditis. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is MARCH8.

UniProtKB/Swiss-Prot: MARH2_HUMAN, Q9P0N8
Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their
subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin
from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to
targeted substrates. May be involved in endosomal trafficking through interaction with STX6

Gene Wiki entry for MARCH2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MARCH2 gene promoter:
         RFX1   Pax-5   HTF   p300   CUTL1   Nkx2-5   NF-Y   ATF   CBF(2)   En-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MARCH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARCH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

MARCH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCH2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P008478:  view genomic region     (about GC identifiers)

Start:
8,478,154 bp from pter      End:
8,503,901 bp from pter
Size:
25,748 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MARH2_HUMAN, Q9P0N8 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MARCH2  
Size: 246 amino acids; 26995 Da
Subunit: Interacts with STX6 (By similarity). Interacts with MARCH3
Secondary accessions: A6NP10 Q5H785 Q8N5A3 Q96B78
Alternative splicing: 2 isoforms:  Q9P0N8-1   Q9P0N8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MARCH2: NX_Q9P0N8

Explore proteomics data for MARCH2 at MOPED

Selected DME Specific Peptides for MARCH2 (Q9P0N8) (see all 11)
 CRICHEG  RPRPLTEWL  DGRLLSTVI  TEWLKDPGPR 


See MARCH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001005415.1  NP_001005416.1  NP_057580.3  

ENSEMBL proteins: 
 ENSP00000370423   ENSP00000472027   ENSP00000471619   ENSP00000469386   ENSP00000471411  
 ENSP00000471536   ENSP00000377518   ENSP00000215555  

MARCH2 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Proteins for MARCH2
OriGene Protein Over-expression Lysate for MARCH2
OriGene MassSpec for MARCH2
OriGene Custom Protein Services for MARCH2
GenScript Custom Purified and Recombinant Proteins Services for MARCH2
Novus Biologicals MARCH2 Proteins
Novus Biologicals MARCH2 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

MARCH2 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for MARCH2
OriGene Custom Antibody Services for MARCH2
Novus Biologicals MARCH2 Antibodies
Search for Antibodies for MARCH2 at Abcam
Browse Antibodies at Cloud-Clone Corp.
ThermoFisher Antibodies for MARCH2
Search LSBio for Antibodies for MARCH2

MARCH2 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for MARCH2
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for MARCH2
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
RNF: RING-type (C3HC4) zinc fingers
MARCH: MARCH membrane-associated ring fingers

2 InterPro protein domains:
 IPR013083 Znf_RING/FYVE/PHD
 IPR011016 Znf_RING-CH

Graphical View of Domain Structure for InterPro Entry Q9P0N8

ProtoNet protein and cluster: Q9P0N8

2 Blocks protein domains:
IPB001841 Zn-finger
IPB011016 RINGv


UniProtKB/Swiss-Prot: MARH2_HUMAN, Q9P0N8
Domain: The RING-CH-type zinc finger domain is required for E3 ligase activity
Similarity: Contains 1 RING-CH-type zinc finger


MARCH2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: MARH2_HUMAN, Q9P0N8
Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their
subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin
from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to
targeted substrates. May be involved in endosomal trafficking through interaction with STX6

     Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004842ubiquitin-protein ligase activity IDA14722266
GO:0005515protein binding ----
GO:0008270zinc ion binding IEA--
GO:0046872metal ion binding ----
     
MARCH2 for ontologies           About GeneDecksing


Phenotypes:
     3 GenomeRNAi human phenotypes for MARCH2:
 Decreased Wnt reporter activit  Decreased viability of wild-ty  Increased G1 DNA content 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MARCH2
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MARCH2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARCH2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARCH2

miRNA
Products:
    
miRTarBase miRNAs that target MARCH2:
hsa-mir-148b-3p (MIRT019377)

Block miRNA regulation of human, mouse, rat MARCH2 using miScript Target Protectors
5 qRT-PCR Assays for microRNAs that regulate MARCH2:
hsa-miR-142-5p hsa-miR-891b hsa-miR-3127-5p hsa-miR-340 hsa-miR-664
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for MARCH2
Predesigned siRNA for gene silencing in human, mouse, rat MARCH2

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for MARCH2

Clone
Products:
     
OriGene clones in human, mouse for MARCH2 (see all 16)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for MARCH2
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH2

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for MARCH2
Browse ESI BIO Cell Lines and PureStem Progenitors for MARCH2 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
MARH2_HUMAN, Q9P0N8: Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass
membrane protein. Endosome membrane; Multi-pass membrane protein (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endoplasmic reticulum5
endosome5
lysosome5
vacuole5
plasma membrane3
cytosol2

Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005765lysosomal membrane IEA--
GO:0005783endoplasmic reticulum IDA14722266
GO:0005789endoplasmic reticulum membrane IEA--
GO:0010008endosome membrane IEA--
GO:0016021integral component of membrane IEA--

MARCH2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus



UniProtKB/Swiss-Prot: MARH2_HUMAN, Q9P0N8
Pathway: Protein modification; protein ubiquitination

    Pathway & Disease-focused RT2 Profiler PCR Array including MARCH2: 

          Ubiquitin Ligases in human mouse rat

Interactions:

    GeneGlobe Interaction Network for MARCH2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for MARCH2 (Q9P0N83 ENSP000002155554) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
InteractantInteraction Details
GeneCardExternal ID(s)
DLG1Q129593, ENSP000003457314I2D: score=1 STRING: ENSP00000345731
STX6O437523, ENSP000002583014I2D: score=2 STRING: ENSP00000258301
UBE2HP622563, ENSP000003478364I2D: score=2 STRING: ENSP00000347836
NPLOC4ENSP000003314874STRING: ENSP00000331487
UBE2G2ENSP000003383484STRING: ENSP00000338348
About this table

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006897endocytosis IEA--
GO:0016567protein ubiquitination IDA14722266

MARCH2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MARCH2 (MARH2)

4 HMDB Compounds for MARCH2    About this table
CompoundSynonyms CAS #PubMed Ids
Adenosine monophosphate5'-AMP (see all 28)61-19-8--
Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for MARCH2 gene (3 alternative transcripts): 
NM_001005415.1  NM_001005416.1  NM_016496.4  

Unigene Cluster for MARCH2:

Membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
Hs.631861  [show with all ESTs]
Unigene Representative Sequence: BC032624
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000381035(uc002mjx.3) ENST00000595142 ENST00000601724 ENST00000601283
ENST00000595213 ENST00000602117 ENST00000594796 ENST00000393944(uc002mjv.3)
ENST00000215555(uc002mjw.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat MARCH2 using miScript Target Protectors
5 qRT-PCR Assays for microRNAs that regulate MARCH2:
hsa-miR-142-5p hsa-miR-891b hsa-miR-3127-5p hsa-miR-340 hsa-miR-664
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for MARCH2
Predesigned siRNA for gene silencing in human, mouse, rat MARCH2
Clone
Products:
     
OriGene clones in human, mouse for MARCH2 (see all 16)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for MARCH2
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARCH2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH2
Primer
Products:
    
OriGene qPCR primer pairs and template standards for MARCH2
OriGene qSTAR qPCR primer pairs in human, mouse for MARCH2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARCH2
  QuantiTect SYBR Green Assays in human, mouse, rat MARCH2
  QuantiFast Probe-based Assays in human, mouse, rat MARCH2

Additional mRNA sequence: 

AB197929.1 AF151074.1 AK130163.1 BC015910.1 BC032624.1 BC111388.1 

7 DOTS entries:

DT.108132  DT.100811450  DT.100811449  DT.92421587  DT.438268  DT.87010044  DT.95268219 

Selected AceView cDNA sequences (see all 84):

AW206208 BE671273 BE467905 AI198308 BQ059396 AI093223 BM919359 AW134783 
BI193168 BV174776 BG180936 BX452406 AI025192 BQ016196 AF151074 BX420869 
BI553695 BC032624 BG769376 AA663800 AI969222 BQ015507 AI668895 AI277491 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for MARCH2    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:                                    
SP2:                    -               


ECgene alternative splicing isoforms for MARCH2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

MARCH2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCACCTTCTG
MARCH2 Expression
About this image


MARCH2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 8) fully expand
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Cerebral Cortex
 
 Ovary (Reproductive System)    fully expand to see all 2 entries
         Ovarian Mesenchymal Stroma Cells Ovary Interstitium
         Oviduct
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Bone Marrow
 
 Trophoblast (Extraembryonic Tissues)
         Trophoblast Cells Trophoblast
 
 Testis (Reproductive System)
         Leydig Cells Testis Interstitium
MARCH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MARCH2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.631861

UniProtKB/Swiss-Prot: MARH2_HUMAN, Q9P0N8
Tissue specificity: Broadly expressed

    Pathway & Disease-focused RT2 Profiler PCR Array including MARCH2: 
          Ubiquitin Ligases in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for MARCH2
OriGene qSTAR qPCR primer pairs in human, mouse for MARCH2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARCH2
QuantiTect SYBR Green Assays in human, mouse, rat MARCH2
QuantiFast Probe-based Assays in human, mouse, rat MARCH2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals and fungi.

Orthologs for MARCH2 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia March21 , 5 membrane-associated ring finger (C3HC4) 21, 5 84.69(n)1
94.72(a)1
  17 (17.98 cM)5
2247031  NM_001252480.11  NP_001239409.11 
 336856925 
chicken
(Gallus gallus)
Aves MARCH21 membrane-associated ring finger (C3HC4) 2 76.15(n)
80.49(a)
  420062  XM_418182.3  XP_418182.2 
tropical clawed frog
(Xenopus tropicalis)
Amphibia march21 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin more 69.92(n)
78.46(a)
  549760  NM_001017006.2  NP_001017006.1 
zebrafish
(Danio rerio)
Actinopterygii march21 membrane-associated ring finger (C3HC4) 2 74.8(n)
78.05(a)
  555611  NM_001044790.2  NP_001038255.2 
fruit fly
(Drosophila melanogaster)
Insecta CG134426
--
13(a)
many ↔ many
2R(16615329-16618115)
worm
(Caenorhabditis elegans)
Secernentea marc-36
Protein C17E4.3 (C17E4.3) mRNA, complete cds
14(a)
1 → many
I(9416703-9418876) WBGene00007643
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSM46
Ubiquitin-protein ligase involved in ER-associated...
4(a)
1 → many
IX(296050-300009) YIL030C


ENSEMBL Gene Tree for MARCH2 (if available)
TreeFam Gene Tree for MARCH2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for MARCH2 gene
MARCH82  MARCH62  MARCH32  MARCH12  
1 SIMAP similar gene for MARCH2 using alignment to 5 protein entries:     MARH2_HUMAN (see all proteins):
MARCH3

MARCH2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for MARCH2 (see all 662)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs355188661,2
C--8148373(+) AATAC-/A/AA  
        
AAAAA
3 -- int11NA 2
rs116675161,2
C,F,H--8476316(+) CCTGCC/TACAAA 3 -- us2k114Minor allele frequency- T:0.08NS EA NA WA 1966
rs116672771,2
C,F,H--8476358(+) gcaatG/Agaagg 3 -- us2k1 tfbs31Minor allele frequency- A:0.02NA 120
rs81083881,2
A--8476490(+) atgctG/Tgatcc 3 -- us2k10--------
rs81085001,2
A--8476567(+) agtggC/Tgaggt 3 -- us2k10--------
rs1124189831,2
F--8476583(+) CTCACT/AGCAGC 3 -- us2k13Minor allele frequency- A:0.05CSA WA 121
rs81041011,2
C,F,A,H--8476587(+) ctgcaA/Gcccag 3 -- us2k1 tfbs312Minor allele frequency- G:0.37NA WA CSA EA 375
rs341693491,2
C,F--8476611(+) AATTGA/GTCCTC 3 -- us2k14Minor allele frequency- G:0.38NA CSA 8
rs1139643361,2
C,F--8476784(+) GGATTG/ACAGAC 3 -- us2k13Minor allele frequency- A:0.13NA WA 240
rs621175201,2
C,F--8476807(+) GCCTGG/ACCTGG 3 -- us2k12Minor allele frequency- A:0.07WA NA 238

HapMap Linkage Disequilibrium report for MARCH2 (8478154 - 8503901 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for MARCH2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv513514CNV Insertion21212237
nsv911005CNV Loss21882294
nsv911004CNV Loss21882294
nsv911003CNV Loss21882294
nsv911001CNV Loss21882294
dgv3719n71CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MARCH2
DNA2.0 Custom Variant and Variant Library Synthesis for MARCH2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 613332    OMIM disorders: --

5 diseases for MARCH2:    
About MalaCards
tonsillitis    thyroiditis    cerebritis    endotheliitis
prostatitis


MARCH2 for disorders           About GeneDecksing


Export disorders for MARCH2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for MARCH2 gene, integrated from 10 sources (see all 16):
(articles sorted by number of sources associating them with MARCH2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PubMed id 14722266)1, 2, 3 Bartee E.... Frueh K. (J. Virol. 2004)
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
  3. MARCH-III is a novel component of endosomes with properties similar to those of MARCH-II. (PubMed id 16428329)1, 2 Fukuda H.... Hirose S. (J. Biochem. 2006)
  4. MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking. (PubMed id 15689499)1, 2 Nakamura N.... Hirose S. (Mol. Biol. Cell 2005)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Ubiquitination and degradation of CFTR by the E3 ubiquitin ligase MARCH2 through its association with adaptor proteins CAL and STX6. (PubMed id 23818989)1 Cheng J. and Guggino W. (PLoS ONE 2013)
  7. MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound I^(2)-adrenergic receptors. (PubMed id 23166351)1 Han S.O....Shenoy S.K. (J. Cell Biol. 2012)
  8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
  9. DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact. (PubMed id 17980554)1 Cao Z....Xavier R.J. (Cell. Signal. 2008)
  10. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PubMed id 17192395)1 Macaulay I.C....Ouwehand W.H. (Blood 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 51257 HGNC: 28038 AceView: MARCH-II Ensembl:ENSG00000099785 euGenes: HUgn51257
ECgene: MARCH2 H-InvDB: MARCH2

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for MARCH2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for MARCH2 gene:
Search GeneIP for patents involving MARCH2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for MARCH2   OriGene RNAi products in human, mouse, rat for MARCH2  
 OriGene qPCR primer pairs and template standards for MARCH2   OriGene Protein Over-expression Lysate for MARCH2  
 OriGene MassSpec something-or-other for MARCH2   OriGene clones in human, mouse for MARCH2  
 OriGene qSTAR qPCR primer pairs in human, mouse for MARCH2   OriGene Purified Protein for MARCH2  
 Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for MARCH2   OriGene Custom Protein Services for MARCH2  

 
 
 Block miRNA regulation of human, mouse, rat MARCH2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MARCH2
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARCH2 Predesigned siRNA for gene silencing in human, mouse, rat MARCH2
 QuantiFast Probe-based Assays in human, mouse, rat MARCH2 QuantiTect SYBR Green Assays in human, mouse, rat MARCH2
 PCR Arrays including human, mouse, rat MARCH2 Search Chromatin IP Primers for MARCH2
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MARCH2  GeneGlobe Interaction Network for MARCH2
 Regulatory tfbs in MARCH2 promoter
 GenScript Custom Purified and Recombinant Proteins Services for MARCH2 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for MARCH2
 GenScript Custom Assay Services for MARCH2 GenScript Custom overexpressing Cell Line Services for MARCH2
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for MARCH2 (MARH2)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 MARCH2 antibodies
 MARCH2 proteins
 MARCH2 lysates
 Search for Antibodies for MARCH2 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for MARCH2
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for MARCH2
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH2
 Browse SwitchGear 3'UTR luciferase reporter plasmids for MARCH2
 Browse SwitchGear Promoter luciferase reporter plasmids for MARCH2
 ThermoFisher Antibodies for MARCH2
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARCH2
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MARCH2
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MARCH2
 Search LSBio for Antibodies for MARCH2
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      MARCH2 gene at Home site.
Version: 3.12.166 28 Aug 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4