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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MARCH11 Gene

protein-coding   GIFtS: 40
GCID: GC05M016123

membrane-associated ring finger (C3HC4) 11

  Search for MARCH11
in our new
 Human Malady Compendium 
Biological research products
for MARCH11
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Membrane-Associated Ring Finger (C3HC4) 111 2
MARCH-XI1 2 3
Membrane-Associated RING Finger Protein 112 3
Membrane-Associated RING-CH Protein XI2 3
E3 Ubiquitin-Protein Ligase MARCH112
EC 6.3.2.-3

External Ids:    HGNC: 336091   Entrez Gene: 4410612   Ensembl: ENSG000001836547   OMIM: 6133385   UniProtKB: A6NNE93   

Export aliases for MARCH11 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MARCH11:
MARCH11 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). These enzymes add
ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their intracellular transport.
March11 appears to have a role in ubiquitin-mediated protein sorting in the trans-Golgi network (TGN)-multivesicular
body (MVB) transport pathway (Morokuma et al., 2007 (PubMed 17604280)).(supplied by OMIM, Apr 2010)

UniProtKB/Swiss-Prot: MARHB_HUMAN, A6NNE9
Function: E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin
from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to
targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MARCH11 gene promoter:
         TBP   AP-1   HNF-4alpha2   AP-4   STAT5A   Ik-3   RORalpha2   E47   AREB6   En-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MARCH11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARCH11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.1   Ensembl cytogenetic band:  5p15.1   HGNC cytogenetic band: 5p15.1

MARCH11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCH11 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M016123:  view genomic region     (about GC identifiers)

Start:
16,067,248 bp from pter      End:
16,180,871 bp from pter
Size:
113,624 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MARHB_HUMAN, A6NNE9 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MARCH11  
Size: 402 amino acids; 43878 Da
Subunit: Interacts (YXXL motif) with AP1M1. Interacts (via PDZ-binding motif) with LIN7A. Interacts with unidentified
fucose glycoproteins (By similarity)
Subcellular location: Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: A7E2S6
Alternative splicing: 2 isoforms:  A6NNE9-1   A6NNE9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MARCH11: NX_A6NNE9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A6NNE9

  • MARCH11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001096032.1  
    ENSEMBL proteins: 
     ENSP00000333181   ENSP00000424425  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--
    GO:0030659cytoplasmic vesicle membrane IEA--


    MARCH11 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MARCH11 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR013083 Znf_RING/FYVE/PHD
     IPR011016 Znf_RING-CH

    Graphical View of Domain Structure for InterPro Entry A6NNE9

    ProtoNet protein and cluster: A6NNE9

    UniProtKB/Swiss-Prot: MARHB_HUMAN, A6NNE9
    Domain: The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity)
    Similarity: Contains 1 RING-CH-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MARHB_HUMAN, A6NNE9
    Function: E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin
    from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to
    targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids (By
    similarity)

    Enzyme Number (IUBMB): EC 6.3.2.-1

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--


    MARCH11 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: MARHB_HUMAN, A6NNE9
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MARCH11

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for MARCH11 (A6NNE93 ENSP000003331814) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    LIN7CQ9NUP93, ENSP000002781934I2D: score=1 STRING: ENSP00000278193
    AP1M1Q9BXS53I2D: score=1 
    LIN7AO149103I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--


    MARCH11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MARCH11
    Search CenterWatch for drugs/clinical trials and news about MARCH11 / MARHB 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for MARCH11 gene: 
    NM_001102562.1  

    Unigene Cluster for MARCH11:

    Membrane-associated ring finger (C3HC4) 11
    Hs.662216  [show with all ESTs]
    Unigene Representative Sequence: NM_001102562
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332432(uc010itw.1 uc003jfo.2) ENST00000507111 ENST00000505509


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    Additional cDNA sequence: 

    BC150513.1 BC150514.1 

    2 DOTS entries:

    DT.206078  DT.92040294 

    21 AceView cDNA sequences:

    AA781829 BF990882 CR590337 BX097533 AW070319 BU941442 BF990862 AI216127 
    BX332938 AI554146 AA868748 BF311739 AA383208 BX332939 AI300637 BG185745 
    BG209034 AI823335 CD243948 BF368822 BG219530 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MARCH11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGACTTATC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    MARCH11 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesMature Sertoli CellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See MARCH11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MARCH11

    SOURCE GeneReport for Unigene cluster: Hs.662216
        SABiosciences Expression via Pathway-Focused PCR Array including MARCH11: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MARCH11 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves MARCH111 membrane-associated ring finger (C3HC4) 11 70.47(n)
    72.37(a)
      420914  XM_419001.3  XP_419001.3 
    lizard
    (Anolis carolinensis)
    Reptilia MARCH116
    --
    91(a)
    1 ↔ 1
    4(60307093-60321404)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-283p23.11 si:ch211-283p23.1 58.72(n)
    55.7(a)
      798174  XM_001338596.1  XP_001338632.1 


    ENSEMBL Gene Tree for MARCH11 (if available)
    TreeFam Gene Tree for MARCH11 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MARCH11 gene
    MARCH82  MARCH32  MARCH12  MARCH42  MARCH22  MARCH92  
    2 SIMAP similar genes for MARCH11 using alignment to 2 protein entries:     MARHB_HUMAN (see all proteins):
    MARCH9    MARCH4

    MARCH11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2007 NCBI SNPs in MARCH11 are shown (see all 2007    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1441796781,2
    --16067019(+) CTCTCC/TGTTTC 1 -- ds50010--------
    rs1465591461,2
    --16067044(+) AAGACA/GTAAGT 1 -- ds50010--------
    rs1813189401,2
    --16067211(+) CTTAAC/TCATTT 1 -- ds50010--------
    rs1867318781,2
    --16067223(+) TAACAA/GGTCTG 1 -- ds50010--------
    rs1404010391,2
    --16067247(+) AGAGCA/GAAAGC 1 -- ds50010--------
    rs1441640851,2
    --16067258(+) TTTCAC/TAAAAA 1 -- ds50010--------
    rs1884525141,2
    --16067300(+) TGGCCG/TTAAGG 1 -- ds50010--------
    rs1816431201,2
    --16067365(+) TCAAGC/TACCAA 1 -- ds50010--------
    rs65549091,2
    C,F,A,--16067431(+) GAAAAA/TTGTAT 1 -- ds50013Minor allele frequency- T:0.18CSA WA 122
    rs1857200011,2
    --16067450(+) CAAATA/GTTCAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MARCH11 (16067248 - 16180871 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for MARCH11
         2 CNVs: 99069 69018
         6 Indels: 80839 92902 10898 64132 12657 64131
         1 Inversion: 59806

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MARCH11 for disorders           About MalaCards

    MARCH11 for disorders           About GeneDecksing

    OMIM gene information: 613338    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: MARCH11 (1 document)

    Export disorders for MARCH11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MARCH11 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MARCH11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MARCH-XI, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids. (PubMed id 17604280)1, 3 Morokuma Y....Hirose S. (2007)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    3. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 441061 HGNC: 33609 AceView: LOC441061 Ensembl:ENSG00000183654 euGenes: HUgn441061
    ECgene: MARCH11 H-InvDB: MARCH11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MARCH11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MARCH11 gene:
    Search GeneIP for patents involving MARCH11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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    Advanced Cell Diagnostics
    About This Section

     
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     Browse OriGene Antibodies   OriGene shRNA RFP for MARCH11  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MARCH11   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MARCH11  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for MARCH11   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MARCH11   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MARCH11  
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     OriGene Custom Antibody Services for MARCH11   OriGene Custom Protein Services for MARCH11  
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MARCH11
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MARCH11
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARCH11
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARCH11
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARCH11
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARCH11
     GenScript Custom Purified and Recombinant Proteins Services for MARCH11 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for MARCH11
     GenScript Custom Assay Services for MARCH11 GenScript Custom Superior Antibodies Services for MARCH11
     GenScript Custom overexpressing Cell Line Services for MARCH11 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
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     Regulatory tfbs in MARCH11 promoter
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     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for MARCH11
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     Search ThermoFisher Antibodies for MARCH11
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MARCH11
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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