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Aliases for MARCH11 Gene

Aliases for MARCH11 Gene

  • Membrane Associated Ring-CH-Type Finger 11 2 3 5
  • Membrane-Associated Ring Finger (C3HC4) 11 2 3
  • Membrane-Associated RING Finger Protein 11 3 4
  • RING-Type E3 Ubiquitin Transferase MARCH11 3 4
  • Membrane-Associated RING-CH Protein XI 3 4
  • MARCH-XI 3 4
  • E3 Ubiquitin-Protein Ligase MARCH11 3
  • Membrane Associated Ring Finger 11 3
  • EC 2.3.2.27 4
  • RNF226 3

External Ids for MARCH11 Gene

Previous GeneCards Identifiers for MARCH11 Gene

  • GC05M016123

Summaries for MARCH11 Gene

Entrez Gene Summary for MARCH11 Gene

  • MARCH11 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). These enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their intracellular transport. March11 appears to have a role in ubiquitin-mediated protein sorting in the trans-Golgi network (TGN)-multivesicular body (MVB) transport pathway (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]

GeneCards Summary for MARCH11 Gene

MARCH11 (Membrane Associated Ring-CH-Type Finger 11) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is MARCH4.

UniProtKB/Swiss-Prot for MARCH11 Gene

  • E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids.

Additional gene information for MARCH11 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH11 Gene

Genomics for MARCH11 Gene

GeneHancer (GH) Regulatory Elements for MARCH11 Gene

Promoters and enhancers for MARCH11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I016179 Promoter 1.1 Ensembl 550.8 +1.7 1661 0.2 SIN3A IRF4 ZSCAN9 RFX5 RARA GLIS2 ZNF143 THAP11 EGR2 HCFC1 MARCH11 LOC401176 ENSG00000250981
GH05I016180 Promoter 0.6 EPDnew 550.8 +1.0 951 0.1 EZH2 MARCH11 LOC401176 ENSG00000250981
GH05I016181 Enhancer 0.3 FANTOM5 558.4 -1.3 -1272 0.3 EZH2 MARCH11 LOC401176 ENSG00000250981 NACAP6
GH05I016089 Enhancer 0.2 FANTOM5 4.2 +91.2 91162 0 MARCH11 ENSG00000250981 GC05P016040
GH05I016141 Enhancer 0.2 ENCODE 0.3 +39.3 39275 0.2 ENSG00000250981 LOC401176 MARCH11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MARCH11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MARCH11 gene promoter:

Genomic Locations for MARCH11 Gene

Genomic Locations for MARCH11 Gene
chr5:16,067,139-16,180,762
(GRCh38/hg38)
Size:
113,624 bases
Orientation:
Minus strand
chr5:16,067,248-16,180,871
(GRCh37/hg19)

Genomic View for MARCH11 Gene

Genes around MARCH11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCH11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCH11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH11 Gene

Proteins for MARCH11 Gene

  • Protein details for MARCH11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NNE9-MARHB_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MARCH11
    Protein Accession:
    A6NNE9
    Secondary Accessions:
    • A7E2S6

    Protein attributes for MARCH11 Gene

    Size:
    402 amino acids
    Molecular mass:
    43878 Da
    Quaternary structure:
    • Interacts (YXXL motif) with AP1M1. Interacts (via PDZ-binding motif) with LIN7A. Interacts with unidentified fucose glycoproteins.

    Alternative splice isoforms for MARCH11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARCH11 Gene

Post-translational modifications for MARCH11 Gene

No Post-translational modifications

Other Protein References for MARCH11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MARCH11 Gene

Domains & Families for MARCH11 Gene

Gene Families for MARCH11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MARCH11 Gene

Graphical View of Domain Structure for InterPro Entry

A6NNE9

UniProtKB/Swiss-Prot:

MARHB_HUMAN :
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
Domain:
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
genes like me logo Genes that share domains with MARCH11: view

No data available for Suggested Antigen Peptide Sequences for MARCH11 Gene

Function for MARCH11 Gene

Molecular function for MARCH11 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids.

Enzyme Numbers (IUBMB) for MARCH11 Gene

Phenotypes From GWAS Catalog for MARCH11 Gene

Gene Ontology (GO) - Molecular Function for MARCH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MARCH11: view

Phenotypes for MARCH11 Gene

GenomeRNAi human phenotypes for MARCH11:
genes like me logo Genes that share phenotypes with MARCH11: view

Animal Model Products

miRNA for MARCH11 Gene

miRTarBase miRNAs that target MARCH11

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MARCH11 Gene

Localization for MARCH11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCH11 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARCH11 gene
Compartment Confidence
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
golgi apparatus 1
endosome 1

Gene Ontology (GO) - Cellular Components for MARCH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with MARCH11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MARCH11 Gene

Pathways & Interactions for MARCH11 Gene

SuperPathways for MARCH11 Gene

No Data Available

UniProtKB/Swiss-Prot A6NNE9-MARHB_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MARCH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MARCH11: view

No data available for Pathways by source and SIGNOR curated interactions for MARCH11 Gene

Drugs & Compounds for MARCH11 Gene

No Compound Related Data Available

Transcripts for MARCH11 Gene

mRNA/cDNA for MARCH11 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MARCH11 Gene

Membrane-associated ring finger (C3HC4) 11:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH11 Gene

No ASD Table

Relevant External Links for MARCH11 Gene

GeneLoc Exon Structure for
MARCH11
ECgene alternative splicing isoforms for
MARCH11

Expression for MARCH11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MARCH11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MARCH11 Gene

This gene is overexpressed in Testis (x27.9) and Pituitary (x4.3).

Protein differential expression in normal tissues from HIPED for MARCH11 Gene

This gene is overexpressed in Retina (47.6), Prostate (8.2), and Fetal testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MARCH11 Gene



SOURCE GeneReport for Unigene cluster for MARCH11 Gene:

Hs.662216
genes like me logo Genes that share expression patterns with MARCH11: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARCH11 Gene

Orthologs for MARCH11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCH11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARCH11 33 34
  • 98.92 (n)
dog
(Canis familiaris)
Mammalia MARCH11 33 34
  • 93.72 (n)
cow
(Bos Taurus)
Mammalia MARCH11 33 34
  • 91.03 (n)
mouse
(Mus musculus)
Mammalia March11 33 16 34
  • 88.01 (n)
rat
(Rattus norvegicus)
Mammalia March11 33
  • 87.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MARCH11 34
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MARCH11 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves MARCH11 34
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MARCH11 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia march11 33
  • 78.01 (n)
zebrafish
(Danio rerio)
Actinopterygii march11 33 34
  • 64.74 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
OneToMany
Species where no ortholog for MARCH11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARCH11 Gene

ENSEMBL:
Gene Tree for MARCH11 (if available)
TreeFam:
Gene Tree for MARCH11 (if available)

Paralogs for MARCH11 Gene

Paralogs for MARCH11 Gene

(2) SIMAP similar genes for MARCH11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MARCH11: view

Variants for MARCH11 Gene

Sequence variations from dbSNP and Humsavar for MARCH11 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000034561 -- 16,179,705(-) G/C 5_prime_UTR_variant
rs1000042274 -- 16,129,621(-) T/C intron_variant
rs1000092540 -- 16,157,371(-) C/A intron_variant
rs1000124422 -- 16,139,182(-) G/T intron_variant
rs1000125145 -- 16,130,602(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH11 Gene

Variant ID Type Subtype PubMed ID
dgv3048n106 CNV deletion 24896259
dgv9617n54 CNV loss 21841781
dgv9618n54 CNV loss 21841781
dgv9619n54 CNV gain 21841781
dgv9620n54 CNV gain 21841781
dgv9621n54 CNV loss 21841781
esv1968274 CNV deletion 18987734
esv25496 CNV loss 19812545
esv2567134 CNV deletion 19546169
esv25878 CNV loss 19812545
esv2659075 CNV deletion 23128226
esv2676039 CNV deletion 23128226
esv2729828 CNV deletion 23290073
esv29154 CNV loss 19812545
esv3565572 CNV deletion 23714750
esv3570007 CNV loss 25503493
esv3604123 CNV loss 21293372
esv3604124 CNV loss 21293372
esv3604125 CNV loss 21293372
esv6332 OTHER inversion 19470904
nsv1073441 CNV deletion 25765185
nsv1114652 CNV deletion 24896259
nsv1133595 CNV deletion 24896259
nsv330082 CNV deletion 16902084
nsv471738 CNV loss 16327809
nsv507233 OTHER sequence alteration 20534489
nsv597297 CNV gain 21841781
nsv597299 CNV gain+loss 21841781
nsv597307 CNV gain 21841781
nsv830217 CNV gain 17160897

Variation tolerance for MARCH11 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MARCH11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MARCH11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH11 Gene

Disorders for MARCH11 Gene

Additional Disease Information for MARCH11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MARCH11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MARCH11 Gene

Publications for MARCH11 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. MARCH-XI, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids. (PMID: 17604280) Morokuma Y … Hirose S (The Journal of biological chemistry 2007) 2 3 58
  3. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel DP … Karasik D (BMC medical genetics 2007) 44 58
  4. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for MARCH11 Gene

Sources for MARCH11 Gene

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