Aliases for MARCH11 Gene
External Ids for MARCH11 Gene
Previous GeneCards Identifiers for MARCH11 Gene
MARCH11 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 22.214.171.124). These enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their intracellular transport. March11 appears to have a role in ubiquitin-mediated protein sorting in the trans-Golgi network (TGN)-multivesicular body (MVB) transport pathway (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]
GeneCards Summary for MARCH11 Gene
MARCH11 (Membrane Associated Ring-CH-Type Finger 11) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is MARCH4.
UniProtKB/Swiss-Prot for MARCH11 Gene
E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids.