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MARCH11 Gene

protein-coding   GIFtS: 40
GCID: GC05M016068

Membrane-Associated Ring Finger (C3HC4) 11

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Membrane-Associated Ring Finger (C3HC4) 111 2
Membrane-Associated RING Finger Protein 112 3
Membrane-Associated RING-CH Protein XI2 3
MARCH-XI2 3
E3 Ubiquitin-Protein Ligase MARCH112
EC 6.3.2.-3

External Ids:    HGNC: 336091   Entrez Gene: 4410612   Ensembl: ENSG000001836547   OMIM: 6133385   UniProtKB: A6NNE93   

Export aliases for MARCH11 gene to outside databases

Previous GC identifer: GC05M016123


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MARCH11 Gene:
MARCH11 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). These enzymes add
ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their intracellular
transport. March11 appears to have a role in ubiquitin-mediated protein sorting in the trans-Golgi network
(TGN)-multivesicular body (MVB) transport pathway (Morokuma et al., 2007 (PubMed 17604280)).(supplied by OMIM,
Apr 2010)

GeneCards Summary for MARCH11 Gene:
MARCH11 (membrane-associated ring finger (C3HC4) 11) is a protein-coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is MARCH4.

UniProtKB/Swiss-Prot: MARHB_HUMAN, A6NNE9
Function: E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept
ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the
ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting
spermatids (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_006576.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MARCH11 gene promoter:
         TBP   AP-1   HNF-4alpha2   AP-4   STAT5A   Ik-3   RORalpha2   E47   AREB6   En-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MARCH11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MARCH11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.1   Ensembl cytogenetic band:  5p15.1   HGNC cytogenetic band: 5p15.1

MARCH11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCH11 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M016068:  view genomic region     (about GC identifiers)

Start:
16,067,248 bp from pter      End:
16,180,871 bp from pter
Size:
113,624 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MARHB_HUMAN, A6NNE9 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MARCH11  
Size: 402 amino acids; 43878 Da
Subunit: Interacts (YXXL motif) with AP1M1. Interacts (via PDZ-binding motif) with LIN7A. Interacts with
unidentified fucose glycoproteins (By similarity)
Secondary accessions: A7E2S6
Alternative splicing: 2 isoforms:  A6NNE9-1   A6NNE9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MARCH11: NX_A6NNE9

Explore proteomics data for MARCH11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MARCH11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001096032.1  
    ENSEMBL proteins: 
     ENSP00000333181   ENSP00000424425  

    MARCH11 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MARCH11 

     
    Search antibodies-online for proteins for MARCH11 

     
    antibodies-online peptides for MARCH11

    MARCH11 Antibody Products:

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    Search for Antibodies for MARCH11 at Abcam
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    Search ThermoFisher Antibodies for MARCH11
    antibodies-online antibodies for MARCH11 (26 products) 

    MARCH11 Assay Products:

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    GenScript Custom Assay Services for MARCH11
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for MARCH11 
    antibodies-online kits for MARCH11 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers
    MARCH: MARCH membrane-associated ring fingers

    2 InterPro protein domains:
     IPR013083 Znf_RING/FYVE/PHD
     IPR011016 Znf_RING-CH

    Graphical View of Domain Structure for InterPro Entry A6NNE9

    ProtoNet protein and cluster: A6NNE9

    UniProtKB/Swiss-Prot: MARHB_HUMAN, A6NNE9
    Domain: The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity)
    Similarity: Contains 1 RING-CH-type zinc finger


    Find genes that share domains with MARCH11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARHB_HUMAN, A6NNE9
    Function: E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept
    ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the
    ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting
    spermatids (By similarity)

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with MARCH11           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MARCH11

    miRNA
    Products:
        
    miRTarBase miRNAs that target MARCH11:
    hsa-mir-124-3p (MIRT022757), hsa-mir-335-5p (MIRT018073)

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    Browse Sino Biological Human cDNA Clones
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MARCH11

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MARHB_HUMAN, A6NNE9: Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome2
    cytosol1
    extracellular1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--
    GO:0030659cytoplasmic vesicle membrane IEA--

    Find genes that share ontologies with MARCH11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: MARHB_HUMAN, A6NNE9
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including MARCH11: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MARCH11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MARCH11 (A6NNE93 ENSP000003331814) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LIN7AO149103, ENSP000002612034I2D: score=1 STRING: ENSP00000261203
    LIN7CQ9NUP93, ENSP000002781934I2D: score=1 STRING: ENSP00000278193
    AP1M1Q9BXS53, ENSP000003889964I2D: score=1 STRING: ENSP00000388996
    NPLOC4ENSP000003314874STRING: ENSP00000331487
    UBE2G2ENSP000003383484STRING: ENSP00000338348
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    Find genes that share ontologies with MARCH11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MARCH11 (MARHB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MARCH11 gene: 
    NM_001102562.1  

    Unigene Cluster for MARCH11:

    Membrane-associated ring finger (C3HC4) 11
    Hs.662216  [show with all ESTs]
    Unigene Representative Sequence: NM_001102562
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332432(uc010itw.1 uc003jfo.2) ENST00000507111 ENST00000505509

    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat MARCH11

    Additional mRNA sequence: 

    BC150513.1 BC150514.1 

    2 DOTS entries:

    DT.206078  DT.92040294 

    21 AceView cDNA sequences:

    BX097533 AW070319 CR590337 AA781829 BF990882 AI216127 BX332938 BU941442 
    AA868748 AI554146 BF990862 BF311739 BX332939 AI823335 AI300637 BG185745 
    BG209034 AA383208 BF368822 CD243948 BG219530 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MARCH11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGACTTATC
    MARCH11 Expression
    About this image


    MARCH11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Testis (Reproductive System)
             Mature Sertoli Cells Seminiferous Tubules
    MARCH11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MARCH11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.662216
        Pathway & Disease-focused RT2 Profiler PCR Array including MARCH11: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MARCH11 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia March111 , 5 membrane-associated ring finger (C3HC4) 111, 5 88.01(n)1
    89.24(a)1
      15 (9.77 cM)5
    2111471  NM_177597.51  NP_808265.21 
     263090485 
    chicken
    (Gallus gallus)
    Aves MARCH116
    membrane-associated ring finger (C3HC4) 11
    81(a)
    1 ↔ 1
    2(75756312-75788084)
    lizard
    (Anolis carolinensis)
    Reptilia MARCH116
    membrane-associated ring finger (C3HC4) 11
    90(a)
    1 ↔ 1
    4(60306620-60321404)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia march111 membrane-associated ring finger (C3HC4) 11 78.01(n)
    88.09(a)
      100487933  XM_002933124.2  XP_002933170.1 
    zebrafish
    (Danio rerio)
    Actinopterygii march111 membrane-associated ring finger (C3HC4) 11 64.74(n)
    67.11(a)
      798174  XM_001338596.2  XP_001338632.1 


    ENSEMBL Gene Tree for MARCH11 (if available)
    TreeFam Gene Tree for MARCH11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MARCH11 gene
    MARCH42  MARCH92  
    2 SIMAP similar genes for MARCH11 using alignment to 2 protein entries:     MARHB_HUMAN (see all proteins):
    MARCH9    MARCH4

    Find genes that share paralogs with MARCH11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MARCH11 (see all 2334)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1441796781,2
    --16067019(+) CTCTCC/TGTTTC 1 -- ds50010--------
    rs1465591461,2
    --16067044(+) AAGACA/GTAAGT 1 -- ds50010--------
    rs1813189401,2
    --16067211(+) CTTAAC/TCATTT 1 -- ds50010--------
    rs1867318781,2
    --16067223(+) TAACAA/GGTCTG 1 -- ds50010--------
    rs1404010391,2
    --16067247(+) AGAGCA/GAAAGC 1 -- ds50010--------
    rs1441640851,2
    --16067258(+) TTTCAC/TAAAAA 1 -- ds50010--------
    rs1884525141,2
    --16067300(+) TGGCCG/TTAAGG 1 -- ds50010--------
    rs1816431201,2
    --16067365(+) TCAAGC/TACCAA 1 -- ds50010--------
    rs65549091,2
    C,F,A--16067431(+) GAAAAA/TTGTAT 1 -- ds50013Minor allele frequency- T:0.18CSA WA 122
    rs1857200011,2
    --16067450(+) CAAATA/GTTCAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MARCH11 (16067248 - 16180871 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MARCH11 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2729828CNV Deletion23290073
    esv2659075CNV Deletion23128226
    esv2676039CNV Deletion23128226
    esv1968274CNV Deletion18987734
    esv2567134CNV Deletion19546169
    nsv507233CNV Insertion20534489
    esv25878CNV Loss19812545
    nsv471738CNV Loss16327809
    nsv330082CNV Loss16902084
    esv25496CNV Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613338    OMIM disorders: --


    Find genes that share disorders with MARCH11           About GenesLikeMe

    Genetic Association Database (GAD): MARCH11
    Human Genome Epidemiology (HuGE) Navigator: MARCH11 (1 document)

    Export disorders for MARCH11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MARCH11 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MARCH11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. MARCH-XI, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids. (PubMed id 17604280)1, 3 Morokuma Y....Hirose S. (J. Biol. Chem. 2007)
    3. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)
    4. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 441061 HGNC: 33609 AceView: LOC441061 Ensembl:ENSG00000183654 euGenes: HUgn441061
    ECgene: MARCH11 H-InvDB: MARCH11

    (According to HUGE)
    About This Section

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MARCH11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MARCH11 gene:
    Search GeneIP for patents involving MARCH11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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