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Aliases for MARCH11 Gene

Aliases for MARCH11 Gene

  • Membrane-Associated Ring Finger (C3HC4) 11 2 3
  • Membrane-Associated RING Finger Protein 11 3 4
  • Membrane-Associated RING-CH Protein XI 3 4
  • MARCH-XI 3 4
  • E3 Ubiquitin-Protein Ligase MARCH11 3
  • EC 6.3.2.- 4

External Ids for MARCH11 Gene

Previous GeneCards Identifiers for MARCH11 Gene

  • GC05M016123

Summaries for MARCH11 Gene

Entrez Gene Summary for MARCH11 Gene

  • MARCH11 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). These enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their intracellular transport. March11 appears to have a role in ubiquitin-mediated protein sorting in the trans-Golgi network (TGN)-multivesicular body (MVB) transport pathway (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]

GeneCards Summary for MARCH11 Gene

MARCH11 (Membrane-Associated Ring Finger (C3HC4) 11) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is MARCH4.

UniProtKB/Swiss-Prot for MARCH11 Gene

  • E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH11 Gene

Genomics for MARCH11 Gene

Regulatory Elements for MARCH11 Gene

Genomic Location for MARCH11 Gene

Start:
16,067,139 bp from pter
End:
16,180,762 bp from pter
Size:
113,624 bases
Orientation:
Minus strand

Genomic View for MARCH11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARCH11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH11 Gene

Proteins for MARCH11 Gene

  • Protein details for MARCH11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NNE9-MARHB_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MARCH11
    Protein Accession:
    A6NNE9
    Secondary Accessions:
    • A7E2S6

    Protein attributes for MARCH11 Gene

    Size:
    402 amino acids
    Molecular mass:
    43878 Da
    Quaternary structure:
    • Interacts (YXXL motif) with AP1M1. Interacts (via PDZ-binding motif) with LIN7A. Interacts with unidentified fucose glycoproteins (By similarity).

    Alternative splice isoforms for MARCH11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARCH11 Gene

Proteomics data for MARCH11 Gene at MOPED

Post-translational modifications for MARCH11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MARCH11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MARCH11 Gene

Domains for MARCH11 Gene

Gene Families for MARCH11 Gene

HGNC:
  • MARCH :MARCH membrane-associated ring fingers
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for MARCH11 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A6NNE9

UniProtKB/Swiss-Prot:

MARHB_HUMAN :
  • A6NNE9
Domain:
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
Similarity:
  • Contains 1 RING-CH-type zinc finger.
genes like me logo Genes that share domains with MARCH11: view

No data available for Suggested Antigen Peptide Sequences for MARCH11 Gene

Function for MARCH11 Gene

Molecular function for MARCH11 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids (By similarity).

Enzyme Numbers (IUBMB) for MARCH11 Gene

Gene Ontology (GO) - Molecular Function for MARCH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with MARCH11: view

Animal Model Products

CRISPR Products

miRNA for MARCH11 Gene

miRTarBase miRNAs that target MARCH11

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MARCH11 Gene

Localization for MARCH11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCH11 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MARCH11 Gene COMPARTMENTS Subcellular localization image for MARCH11 gene
Compartment Confidence
endosome 2
cytosol 1
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MARCH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with MARCH11: view

Pathways for MARCH11 Gene

SuperPathways for MARCH11 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat

UniProtKB/Swiss-Prot A6NNE9-MARHB_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for MARCH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MARCH11: view

No data available for Pathways by source for MARCH11 Gene

Transcripts for MARCH11 Gene

mRNA/cDNA for MARCH11 Gene

(21) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MARCH11 Gene

Membrane-associated ring finger (C3HC4) 11:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MARCH11

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MARCH11
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH11 Gene

No ASD Table

Relevant External Links for MARCH11 Gene

GeneLoc Exon Structure for
MARCH11
ECgene alternative splicing isoforms for
MARCH11

Expression for MARCH11 Gene

mRNA expression in normal human tissues for MARCH11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MARCH11 Gene

This gene is overexpressed in Testis (27.9) and Pituitary (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MARCH11 Gene

SOURCE GeneReport for Unigene cluster for MARCH11 Gene Hs.662216

genes like me logo Genes that share expressions with MARCH11: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MARCH11 Gene

Orthologs for MARCH11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCH11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARCH11 35
  • 98.92 (n)
  • 98.51 (a)
MARCH11 36
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MARCH11 35
  • 91.03 (n)
  • 93.15 (a)
MARCH11 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MARCH11 35
  • 93.72 (n)
  • 99.55 (a)
MARCH11 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia March11 35
  • 88.01 (n)
  • 89.24 (a)
March11 16
March11 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MARCH11 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MARCH11 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia March11 35
  • 87.78 (n)
  • 89.49 (a)
chicken
(Gallus gallus)
Aves MARCH11 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MARCH11 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia march11 35
  • 78.01 (n)
  • 88.09 (a)
zebrafish
(Danio rerio)
Actinopterygii march11 35
  • 64.74 (n)
  • 67.11 (a)
march11 36
  • 58 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for MARCH11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARCH11 Gene

ENSEMBL:
Gene Tree for MARCH11 (if available)
TreeFam:
Gene Tree for MARCH11 (if available)

Paralogs for MARCH11 Gene

Paralogs for MARCH11 Gene

Selected SIMAP similar genes for MARCH11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MARCH11: view

Variants for MARCH11 Gene

Sequence variations from dbSNP and Humsavar for MARCH11 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs163726 -- 16,174,754(+) GACTT(C/T)ATGAG intron-variant
rs168210 -- 16,177,118(+) ACTAG(C/T)TCAGT intron-variant
rs168263 -- 16,167,916(+) AAGTA(A/C)CAATT intron-variant
rs171058 -- 16,174,614(+) CAACA(C/T)GGTAA intron-variant
rs171097 -- 16,167,430(+) ccagc(A/G)tgaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH11 Gene

Variant ID Type Subtype PubMed ID
nsv830217 CNV Gain 17160897
esv2567134 CNV Deletion 19546169
nsv507233 CNV Insertion 20534489
nsv471738 CNV Loss 16327809
esv2676039 CNV Deletion 23128226
esv25496 CNV Loss 19812545
esv2659075 CNV Deletion 23128226
nsv330082 CNV Loss 16902084
esv29154 CNV Loss 19812545
esv6332 OTHER Inversion 19470904
esv1968274 CNV Deletion 18987734
esv2729828 CNV Deletion 23290073
esv25878 CNV Loss 19812545

Relevant External Links for MARCH11 Gene

HapMap Linkage Disequilibrium report
MARCH11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH11 Gene

Disorders for MARCH11 Gene

Relevant External Links for MARCH11

Genetic Association Database (GAD)
MARCH11
Human Genome Epidemiology (HuGE) Navigator
MARCH11
genes like me logo Genes that share disorders with MARCH11: view

No data available for UniProtKB/Swiss-Prot for MARCH11 Gene

Publications for MARCH11 Gene

  1. MARCH-XI, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids. (PMID: 17604280) Morokuma Y. … Hirose S. (J. Biol. Chem. 2007) 2 3
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel D.P. … Karasik D. (BMC Med. Genet. 2007) 48
  4. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for MARCH11 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MARCH11
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MARCH11
    • Block miRNA regulation of MARCH11 using miScript Target Protectors

    Sources for MARCH11 Gene

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