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Aliases for MARCH10 Gene

Aliases for MARCH10 Gene

  • Membrane Associated Ring-CH-Type Finger 10 2 3 5
  • Membrane-Associated Ring Finger (C3HC4) 10, E3 Ubiquitin Protein Ligase 2 3
  • Membrane-Associated RING Finger Protein 10 3 4
  • RING-Type E3 Ubiquitin Transferase MARCH10 3 4
  • Membrane-Associated RING-CH Protein X 3 4
  • Ring Finger Protein 190 2 3
  • MARCH-X 3 4
  • RNF190 3 4
  • Testis Secretory Sperm-Binding Protein Li 228n 3
  • Probable E3 Ubiquitin-Protein Ligase MARCH10 3
  • Membrane-Associated Ring Finger (C3HC4) 10 2
  • Membrane Associated Ring Finger 10 3
  • RING Finger Protein 190 4
  • EC 2.3.2.27 4

External Ids for MARCH10 Gene

Previous HGNC Symbols for MARCH10 Gene

  • RNF190

Previous GeneCards Identifiers for MARCH10 Gene

  • GC17M058134
  • GC17M060778
  • GC17M056145

Summaries for MARCH10 Gene

Entrez Gene Summary for MARCH10 Gene

  • MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]

GeneCards Summary for MARCH10 Gene

MARCH10 (Membrane Associated Ring-CH-Type Finger 10) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is MARCH7.

UniProtKB/Swiss-Prot for MARCH10 Gene

  • E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH10 Gene

Genomics for MARCH10 Gene

Regulatory Elements for MARCH10 Gene

Enhancers for MARCH10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G062750 1.1 FANTOM5 ENCODE 20.8 +57.7 57716 0.6 CTCF SUZ12 ZIC2 ZBTB7B ZKSCAN1 GATA3 POLR2A ZNF207 FOSL2 EZH2 MARCH10 EFCAB3 GC17M062752 GC17P062742
GH17G062789 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.6 +16.2 16224 5.9 HDGF PKNOX1 FOXA2 SIN3A YBX1 FEZF1 ZBTB7B ZNF207 FOS SP3 DDX42 INTS2 MED13 MIR633 STRADA MARCH10 GC17M062789 GC17M062752
GH17G062759 0.8 ENCODE 12.8 +48.1 48081 1.2 HDGF PKNOX1 ARNT NFRKB FEZF1 GLIS2 ZSCAN5C SCRT2 CEBPB OVOL3 MARCH10 RNU6-446P MRC2 MIR633 GC17M062752 GC17M062789
GH17G062723 1.5 Ensembl ENCODE dbSUPER 6.8 +83.2 83230 2.7 PKNOX1 WRNIP1 SIN3A FEZF1 ZBTB7B CBX5 ZNF143 FOS ZNF263 ZHX2 MIR633 MARCH10 LOC105371855 MRC2 GC17M062741
GH17G062761 0.8 ENCODE 12.7 +46.3 46337 0.2 GTF2F1 KLF1 TEAD4 KLF17 FEZF1 RAD21 ZIC2 CTBP1 GATA3 SCRT2 MARCH10 RNU6-446P MRC2 MIR633 GC17M062752 GC17M062789
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MARCH10 on UCSC Golden Path with GeneCards custom track

Promoters for MARCH10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000096718 -19 401 PKNOX1 NFIB SIN3A BMI1 RAD21 ELK1 EGR1 HSF1 EGR2 SP3

Genomic Location for MARCH10 Gene

Chromosome:
17
Start:
62,701,314 bp from pter
End:
62,808,381 bp from pter
Size:
107,068 bases
Orientation:
Minus strand

Genomic View for MARCH10 Gene

Genes around MARCH10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCH10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCH10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH10 Gene

Proteins for MARCH10 Gene

  • Protein details for MARCH10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NA82-MARHA_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase MARCH10
    Protein Accession:
    Q8NA82
    Secondary Accessions:
    • D3DU09
    • Q8IYS7
    • Q8N7Z7

    Protein attributes for MARCH10 Gene

    Size:
    808 amino acids
    Molecular mass:
    90511 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH35021.1; Type=Erroneous termination; Positions=658; Note=Translated as Leu.; Evidence={ECO:0000305}; Sequence=BAC05079.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MARCH10 Gene

Post-translational modifications for MARCH10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MARCH10 Gene

Domains & Families for MARCH10 Gene

Protein Domains for MARCH10 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NA82

UniProtKB/Swiss-Prot:

MARHA_HUMAN :
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
Domain:
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
genes like me logo Genes that share domains with MARCH10: view

No data available for Suggested Antigen Peptide Sequences for MARCH10 Gene

Function for MARCH10 Gene

Molecular function for MARCH10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for MARCH10 Gene

Gene Ontology (GO) - Molecular Function for MARCH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MARCH10: view
genes like me logo Genes that share phenotypes with MARCH10: view

Animal Model Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MARCH10 Gene

Localization for MARCH10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARCH10 gene
Compartment Confidence
cytosol 3
plasma membrane 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MARCH10 Gene

Pathways & Interactions for MARCH10 Gene

SuperPathways for MARCH10 Gene

No Data Available

UniProtKB/Swiss-Prot Q8NA82-MARHA_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MARCH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MARCH10: view

No data available for Pathways by source and SIGNOR curated interactions for MARCH10 Gene

Drugs & Compounds for MARCH10 Gene

(3) Drugs for MARCH10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for MARCH10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with MARCH10: view

Transcripts for MARCH10 Gene

Unigene Clusters for MARCH10 Gene

Membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for MARCH10 Gene

GeneLoc Exon Structure for
MARCH10
ECgene alternative splicing isoforms for
MARCH10

Expression for MARCH10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MARCH10 Gene

mRNA differential expression in normal tissues according to GTEx for MARCH10 Gene

This gene is overexpressed in Testis (x35.5).

Protein differential expression in normal tissues from HIPED for MARCH10 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MARCH10 Gene



Protein tissue co-expression partners for MARCH10 Gene

- Elite partner

SOURCE GeneReport for Unigene cluster for MARCH10 Gene:

Hs.665663

Evidence on tissue expression from TISSUES for MARCH10 Gene

  • Adrenal gland(2.2)
  • Lung(2.2)
  • Pancreas(2.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with MARCH10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARCH10 Gene

Orthologs for MARCH10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCH10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARCH10 34 35
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia MARCH10 34 35
  • 84.15 (n)
cow
(Bos Taurus)
Mammalia MARCH10 34 35
  • 79.97 (n)
mouse
(Mus musculus)
Mammalia March10 34 16 35
  • 74.21 (n)
rat
(Rattus norvegicus)
Mammalia March10 34
  • 73.85 (n)
oppossum
(Monodelphis domestica)
Mammalia MARCH10 35
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MARCH10 35
  • 24 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MARCH10 35
  • 36 (a)
OneToOne
Species where no ortholog for MARCH10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MARCH10 Gene

ENSEMBL:
Gene Tree for MARCH10 (if available)
TreeFam:
Gene Tree for MARCH10 (if available)

Paralogs for MARCH10 Gene

Paralogs for MARCH10 Gene

(3) SIMAP similar genes for MARCH10 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MARCH10: view

Variants for MARCH10 Gene

Sequence variations from dbSNP and Humsavar for MARCH10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000026204 -- 62,787,256(+) TCTAC(A/C)TCTAT intron-variant
rs1000085879 -- 62,701,049(+) AGTCC(C/T)GACTT downstream-variant-500B
rs1000088082 -- 62,740,769(+) CTACA(C/G)GTGCA intron-variant
rs1000091224 -- 62,799,645(+) GGACG(C/T)GGAGG intron-variant
rs1000152299 -- 62,701,234(+) TGGGC(C/T)GTGAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MARCH10 Gene

Variant ID Type Subtype PubMed ID
esv2658945 CNV deletion 23128226
esv2666912 CNV deletion 23128226
esv26867 CNV loss 19812545
nsv1133236 CNV tandem duplication 24896259
nsv2115 CNV insertion 18451855
nsv509665 CNV insertion 20534489
nsv516921 CNV gain+loss 19592680

Variation tolerance for MARCH10 Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MARCH10 Gene

Human Gene Mutation Database (HGMD)
MARCH10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MARCH10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH10 Gene

Disorders for MARCH10 Gene

Relevant External Links for MARCH10

Genetic Association Database (GAD)
MARCH10
Human Genome Epidemiology (HuGE) Navigator
MARCH10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MARCH10

No disorders were found for MARCH10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MARCH10 Gene

Publications for MARCH10 Gene

  1. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 64
  2. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 64
  3. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PMID: 19724895) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2009) 3 46 64
  4. MARCH-XI, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids. (PMID: 17604280) Morokuma Y. … Hirose S. (J. Biol. Chem. 2007) 2 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for MARCH10 Gene

Sources for MARCH10 Gene

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