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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MARCH10 Gene

protein-coding   GIFtS: 47
GCID: GC17M060778

membrane-associated ring finger (C3HC4) 10, E3 ubiquitin...

(Previous names: ring finger protein 190, membrane-associated ring finger...)
(Previous symbol: RNF190)
  Search for MARCH10
in our new
 Human Malady Compendium 
Biological research products
for MARCH10
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Membrane-Associated Ring Finger (C3HC4) 10, E3 Ubiquitin Protein Ligase1 2     Membrane-Associated RING-CH Protein X2 3
RING Finger Protein 1901 2 3     FLJ357571
MARCH-X1 2 3     Membrane-Associated Ring Finger (C3HC4) 101
RNF1901 2 3     Probable E3 Ubiquitin-Protein Ligase MARCH102
Membrane-Associated RING Finger Protein 102 3     EC 6.3.2.-3

External Ids:    HGNC: 266551   Entrez Gene: 1623332   Ensembl: ENSG000001738387   OMIM: 6133375   UniProtKB: Q8NA823   

Export aliases for MARCH10 gene to outside databases

Previous GC identifers: GC17M058134 GC17M056145


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MARCH10:
MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add
ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport
between membrane compartments (Morokuma et al., 2007 (PubMed 17604280)).(supplied by OMIM, Apr 2010)

UniProtKB/Swiss-Prot: MARHA_HUMAN, Q8NA82
Function: E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2
ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted
substrates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MARCH10 gene promoter:
         RORalpha1   AML1a   AP-2alpha isoform 2   AP-2alpha   Hlf   FOXL1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MARCH10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARCH10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2   Ensembl cytogenetic band:  17q23.2   HGNC cytogenetic band: 17q23.3

MARCH10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARCH10 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M060778:  view genomic region     (about GC identifiers)

Start:
60,778,675 bp from pter      End:
60,885,705 bp from pter
Size:
107,031 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MARHA_HUMAN, Q8NA82 (See protein sequence)
Recommended Name: Probable E3 ubiquitin-protein ligase MARCH10  
Size: 808 amino acids; 90511 Da
Sequence caution: Sequence=AAH35021.1; Type=Erroneous termination; Positions=658; Note=Translated as Leu;
Sequence=BAC05079.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: D3DU09 Q8IYS7 Q8N7Z7

Explore the universe of human proteins at neXtProt for MARCH10: NX_Q8NA82

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NA82

  • MARCH10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001094345.1  NP_689811.2  

    ENSEMBL proteins: 
     ENSP00000463207   ENSP00000464220   ENSP00000416177   ENSP00000311496   ENSP00000463080  
     ENSP00000443746   ENSP00000463572   ENSP00000463029  

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    OriGene Protein Over-expression Lysate (see all 3): MARCH10
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    Novus Biologicals MARCH10 Proteins
    Novus Biologicals MARCH10 Lysates
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    Browse Proteins at Uscn


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    Browse ELISAs and CLIAs at Uscn


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MARCH10 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR013083 Znf_RING/FYVE/PHD
     IPR011016 Znf_RING-CH

    Graphical View of Domain Structure for InterPro Entry Q8NA82

    ProtoNet protein and cluster: Q8NA82

    1 Blocks protein family: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: MARHA_HUMAN, Q8NA82
    Domain: The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity)
    Similarity: Contains 1 RING-CH-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MARHA_HUMAN, Q8NA82
    Function: E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2
    ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted
    substrates

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARCH10

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--


    MARCH10 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MARCH10:
     Large cells 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: MARHA_HUMAN, Q8NA82
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MARCH10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for MARCH10 (Q8NA822, 3 ENSP000003114964) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2HP622563, ENSP000003478364I2D: score=2 STRING: ENSP00000347836
    --P310162MINT-8105979
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--


    MARCH10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MARCH10

    4 HMDB Compounds for MARCH10    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about MARCH10 / MARHA 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MARCH10 gene (2 alternative transcripts): 
    NM_001100875.1  NM_152598.2  

    Unigene Cluster for MARCH10:

    Membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
    Hs.665663  [show with all ESTs]
    Unigene Representative Sequence: AK122947
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000582358 ENST00000579620 ENST00000580520 ENST00000456609(uc010ddr.3)
    ENST00000311269 ENST00000583600(uc002jag.4 uc010dds.3) ENST00000544856(uc002jah.2)
    ENST00000582568 ENST00000578346 ENST00000583803

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    hsa-miR-1321 hsa-miR-222* hsa-miR-583
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    Additional cDNA sequence: 

    AK093076.1 AK097506.1 AK122947.1 BC035021.1 BX648705.1 

    6 DOTS entries:

    DT.92415232  DT.100743063  DT.101978959  DT.99989849  DT.91665499  DT.40307114 

    24/32 AceView cDNA sequences (see all 32):

    AK122947 BX105355 AA884615 AI418361 AI262871 AX747906 BX091948 AK093076 
    AI911418 AW274501 AW138484 AK097506 AI285835 AI001159 BX648705 BX106388 
    AI148036 BC035021 NM_152598 AW473122 AI142320 AW269755 AI910935 AW024402 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MARCH10 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
    SP1:                          -     -                 -                                                     -     -               
    SP2:                          -     -                 -           -                                         -     -               
    SP3:                          -                       -           -                                                               
    SP4:                                -                 -           -                                                               
    SP5:                          -     -                                                                                             


    ECgene alternative splicing isoforms for MARCH10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MARCH10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTCATTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MARCH10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MARCH10

    SOURCE GeneReport for Unigene cluster: Hs.665663
        SABiosciences Custom PCR Arrays for MARCH10
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MARCH10 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia March101 , 5 membrane-associated ring finger (C3HC4) 101, 5 75.7(n)1
    64.19(a)1
      11 (68.73 cM)5
    6326871  NM_172568.21  NP_766156.21 
     1053607985 
    lizard
    (Anolis carolinensis)
    Reptilia MARCH106
    --
    40(a)
    1 ↔ 1
    6(61598311-61621534)
    zebrafish
    (Danio rerio)
    Actinopterygii march76
    march76
    membrane-associated ring finger (C3HC4) 7
    20(a)
    20(a)
    many ↔ many
    many ↔ many
    6(11676288-11723015)
    6(11676288-11723171)


    ENSEMBL Gene Tree for MARCH10 (if available)
    TreeFam Gene Tree for MARCH10 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MARCH10 gene
    MARCH72  
    3 SIMAP similar genes for MARCH10 using alignment to 7 protein entries:     MARHA_HUMAN (see all proteins):
    MARCH7    MARCH6    MARCH1

    MARCH10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1865 NCBI SNPs in MARCH10 are shown (see all 1865    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1875412481,2
    --60778236(+) TCCTCA/GGCTTC 2 -- int10--------
    rs564140581,2
    C,--60778320(+) TTTTTA/TAAACA 2 -- int14Minor allele frequency- T:0.12WA NA 8
    rs671534431,2
    C--60778328(+) AAAAAA/CACACA 2 -- int11Minor allele frequency- C:0.00NA 2
    rs800450901,2
    --60778330(+) AAAAAA/CACACA 2 -- int10--------
    rs285626431,2
    --60778332(+) AAACAC/AACACA 2 -- int11Minor allele frequency- A:0.00NA 2
    rs728382711,2
    C,--60778345(+) CACACT/ACGTAC 2 -- int11Minor allele frequency- A:0.50NA 2
    rs24602971,2
    C,F--60778348(+) ACACGC/TACTCA 2 -- int12Minor allele frequency- T:0.50NA 4
    rs711559501,2
    C,--60778348(-) TGAGTGCGAGTGTG
    TTTGAGT
    /-
    ACGTG
    2 -- int11Minor allele frequency- -:0.00NA 2
    rs752772181,2
    --60778367(+) CGCACA/TCACAA 2 -- int10--------
    rs1909689431,2
    --60778396(+) GACCTC/TCCACC 2 -- int10--------

    HapMap Linkage Disequilibrium report for MARCH10 (60778675 - 60885705 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for MARCH10
         1 CNV: 49907
         1 Indel: 72997

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MARCH10 for disorders           About MalaCards

    MARCH10 for disorders           About GeneDecksing

    OMIM gene information: 613337    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: MARCH10 (3 documents)

    Export disorders for MARCH10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MARCH10 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with MARCH10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MARCH-XI, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids. (PubMed id 17604280)1, 3 Morokuma Y....Hirose S. (2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. GWAS for discovery and replication of genetic loci as sociated with sudden cardiac arrest in patients with coronary artery disease. (PubMed id 21658281)1 Aouizerat B.E....Tseng Z.H. (2011)
    5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    6. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1 Oguri M....Yamada Y. (2010)
    7. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1 Yoshida T....Yamada Y. (2010)
    8. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
    9. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PubMed id 19724895)1 Yoshida T....Yamada Y. (2009)
    10. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 162333 HGNC: 26655 AceView: FLJ35757 Ensembl:ENSG00000173838 euGenes: HUgn162333
    ECgene: MARCH10 H-InvDB: MARCH10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MARCH10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MARCH10 gene:
    Search GeneIP for patents involving MARCH10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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