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Aliases for MARCH10 Gene

Aliases for MARCH10 Gene

  • Membrane-Associated Ring Finger (C3HC4) 10, E3 Ubiquitin Protein Ligase 2 3
  • Membrane-Associated RING Finger Protein 10 3 4
  • Membrane-Associated RING-CH Protein X 3 4
  • Ring Finger Protein 190 2 3
  • MARCH-X 3 4
  • RNF190 3 4
  • Probable E3 Ubiquitin-Protein Ligase MARCH10 3
  • Membrane-Associated Ring Finger (C3HC4) 10 2
  • RING Finger Protein 190 4
  • EC 6.3.2.- 4

External Ids for MARCH10 Gene

Previous HGNC Symbols for MARCH10 Gene

  • RNF190

Previous GeneCards Identifiers for MARCH10 Gene

  • GC17M058134
  • GC17M060778
  • GC17M056145

Summaries for MARCH10 Gene

Entrez Gene Summary for MARCH10 Gene

  • MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]

GeneCards Summary for MARCH10 Gene

MARCH10 (Membrane-Associated Ring Finger (C3HC4) 10, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is MARCH7.

UniProtKB/Swiss-Prot for MARCH10 Gene

  • E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH10 Gene

Genomics for MARCH10 Gene

Regulatory Elements for MARCH10 Gene

Genomic Location for MARCH10 Gene

Start:
62,701,314 bp from pter
End:
62,808,381 bp from pter
Size:
107,068 bases
Orientation:
Minus strand

Genomic View for MARCH10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARCH10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH10 Gene

Proteins for MARCH10 Gene

  • Protein details for MARCH10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NA82-MARHA_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase MARCH10
    Protein Accession:
    Q8NA82
    Secondary Accessions:
    • D3DU09
    • Q8IYS7
    • Q8N7Z7

    Protein attributes for MARCH10 Gene

    Size:
    808 amino acids
    Molecular mass:
    90511 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH35021.1; Type=Erroneous termination; Positions=658; Note=Translated as Leu.; Evidence={ECO:0000305}; Sequence=BAC05079.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MARCH10 Gene

Proteomics data for MARCH10 Gene at MOPED

Post-translational modifications for MARCH10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MARCH10 Gene

Domains for MARCH10 Gene

Gene Families for MARCH10 Gene

HGNC:
  • MARCH :MARCH membrane-associated ring fingers
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for MARCH10 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8NA82

UniProtKB/Swiss-Prot:

MARHA_HUMAN :
  • Q8NA82
Domain:
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
Similarity:
  • Contains 1 RING-CH-type zinc finger.
genes like me logo Genes that share domains with MARCH10: view

No data available for Suggested Antigen Peptide Sequences for MARCH10 Gene

Function for MARCH10 Gene

Molecular function for MARCH10 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for MARCH10 Gene

Gene Ontology (GO) - Molecular Function for MARCH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with MARCH10: view

Phenotypes for MARCH10 Gene

GenomeRNAi human phenotypes for MARCH10:
genes like me logo Genes that share phenotypes with MARCH10: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MARCH10 Gene

Localization for MARCH10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MARCH10 Gene COMPARTMENTS Subcellular localization image for MARCH10 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MARCH10 Gene

Pathways for MARCH10 Gene

SuperPathways for MARCH10 Gene

No Data Available

UniProtKB/Swiss-Prot Q8NA82-MARHA_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for MARCH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MARCH10: view

No data available for Pathways by source for MARCH10 Gene

Compounds for MARCH10 Gene

(4) HMDB Compounds for MARCH10 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with MARCH10: view

Transcripts for MARCH10 Gene

Unigene Clusters for MARCH10 Gene

Membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MARCH10

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MARCH10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for MARCH10 Gene

GeneLoc Exon Structure for
MARCH10
ECgene alternative splicing isoforms for
MARCH10

Expression for MARCH10 Gene

mRNA expression in normal human tissues for MARCH10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MARCH10 Gene

This gene is overexpressed in Testis (35.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MARCH10 Gene

SOURCE GeneReport for Unigene cluster for MARCH10 Gene Hs.665663

genes like me logo Genes that share expressions with MARCH10: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MARCH10 Gene

Orthologs for MARCH10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCH10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARCH10 35
  • 99.25 (n)
  • 98.35 (a)
MARCH10 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MARCH10 35
  • 79.97 (n)
  • 71.07 (a)
MARCH10 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MARCH10 35
  • 84.15 (n)
  • 74.59 (a)
MARCH10 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia March10 35
  • 74.21 (n)
  • 62.66 (a)
March10 16
March10 36
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MARCH10 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MARCH10 36
  • 24 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia March10 35
  • 73.85 (n)
  • 62.88 (a)
lizard
(Anolis carolinensis)
Reptilia MARCH10 36
  • 36 (a)
OneToOne
Species with no ortholog for MARCH10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MARCH10 Gene

ENSEMBL:
Gene Tree for MARCH10 (if available)
TreeFam:
Gene Tree for MARCH10 (if available)

Paralogs for MARCH10 Gene

Paralogs for MARCH10 Gene

Selected SIMAP similar genes for MARCH10 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MARCH10: view

Variants for MARCH10 Gene

Sequence variations from dbSNP and Humsavar for MARCH10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs740699 -- 62,714,421(+) CGCAA(A/C)ACCAA intron-variant, reference, synonymous-codon
rs758519 -- 62,744,203(-) TTTGG(C/T)GTTTT intron-variant
rs766038 -- 62,738,689(-) TGGTG(C/T)CCCCC intron-variant
rs917560 -- 62,758,467(-) TCCAC(C/T)AATAT intron-variant
rs1003782 -- 62,749,158(-) TCCCA(A/G)CATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH10 Gene

Variant ID Type Subtype PubMed ID
nsv908680 CNV Loss 21882294
nsv516921 CNV Gain+Loss 19592680
nsv2115 CNV Insertion 18451855
nsv509665 CNV Insertion 20534489
esv26867 CNV Loss 19812545
esv2658945 CNV Deletion 23128226
esv2666912 CNV Deletion 23128226

Relevant External Links for MARCH10 Gene

HapMap Linkage Disequilibrium report
MARCH10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH10 Gene

Disorders for MARCH10 Gene

Relevant External Links for MARCH10

Genetic Association Database (GAD)
MARCH10
Human Genome Epidemiology (HuGE) Navigator
MARCH10
genes like me logo Genes that share disorders with MARCH10: view

No data available for UniProtKB/Swiss-Prot for MARCH10 Gene

Publications for MARCH10 Gene

  1. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PMID: 19724895) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2009) 3 48
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 48
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 48
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MARCH10 Gene

Sources for MARCH10 Gene

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