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Aliases for MARCH1 Gene

Aliases for MARCH1 Gene

  • Membrane Associated Ring-CH-Type Finger 1 2 3 5
  • Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase 2 3
  • Membrane-Associated RING Finger Protein 1 3 4
  • Membrane-Associated RING-CH Protein I 3 4
  • RING Finger Protein 171 3 4
  • MARCH-I 3 4
  • RNF171 3 4
  • Membrane-Associated Ring Finger (C3HC4) 1 2
  • E3 Ubiquitin-Protein Ligase MARCH1 3
  • Membrane Associated Ring Finger 1 3
  • EC 6.3.2.- 4
  • EC 6.3.2 61

External Ids for MARCH1 Gene

Previous GeneCards Identifiers for MARCH1 Gene

  • GC04M164806
  • GC04M164668
  • GC04M164448
  • GC04M160199

Summaries for MARCH1 Gene

Entrez Gene Summary for MARCH1 Gene

  • MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010]

GeneCards Summary for MARCH1 Gene

MARCH1 (Membrane Associated Ring-CH-Type Finger 1) is a Protein Coding gene. GO annotations related to this gene include ligase activity and MHC protein binding. An important paralog of this gene is MARCH8.

UniProtKB/Swiss-Prot for MARCH1 Gene

  • E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH1 Gene

Genomics for MARCH1 Gene

Regulatory Elements for MARCH1 Gene

Enhancers for MARCH1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F163493 1.5 FANTOM5 ENCODE 47.3 +889.3 889311 3.4 PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 MARCH1 ENSG00000273449 TMA16 NAF1 TKTL2
GH04F163544 0.9 Ensembl ENCODE 48.7 +839.1 839130 1.4 CTCF ZNF654 ZFP37 TRIM22 REST RAD21 FOXK2 MBD1 ZNF143 SMC3 MARCH1 TMA16 TKTL2 ENSG00000273449 PIR37872
GH04F163540 0.5 ENCODE 53.2 +842.6 842570 1.8 JUND FOS ZBTB33 MARCH1 TMA16 TKTL2 ENSG00000273449 PIR37872
GH04F163549 1.3 FANTOM5 Ensembl ENCODE 19.9 +833.7 833749 1.0 GTF2F1 CTCF CBX3 USF1 TBL1XR1 MAX ZNF384 RAD21 ZNF143 SMC3 MARCH1 TMA16 TKTL2 ENSG00000273449 PIR37872
GH04F163535 0.4 ENCODE 47.7 +847.8 847785 1.0 CTCF MARCH1 TMA16 TKTL2 ENSG00000273449 PIR37872
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MARCH1 on UCSC Golden Path with GeneCards custom track

Promoters for MARCH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001437045 349 1399 CTCF RNF2 SUZ12 ZIC2 JUND SMARCA4 ZNF692 CTBP2 PRDM10 KDM1A

Genomic Location for MARCH1 Gene

Chromosome:
4
Start:
163,524,298 bp from pter
End:
164,384,050 bp from pter
Size:
859,753 bases
Orientation:
Minus strand

Genomic View for MARCH1 Gene

Genes around MARCH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH1 Gene

Proteins for MARCH1 Gene

  • Protein details for MARCH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCQ1-MARH1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MARCH1
    Protein Accession:
    Q8TCQ1
    Secondary Accessions:
    • D3DP29
    • Q9NWR0

    Protein attributes for MARCH1 Gene

    Size:
    289 amino acids
    Molecular mass:
    32308 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MARCH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARCH1 Gene

Selected DME Specific Peptides for MARCH1 Gene

Q8TCQ1:
  • QDICRICHCEGD
  • FIMETKLKPLRKWEKLQMT
  • LEWPFWTKLVVVAIGFTGGL
  • RLKAYNRVI

Post-translational modifications for MARCH1 Gene

  • Has a short half-life. Instability/short half-life permits rapid changes that allow efficient induction of antigen presentation once antigen presenting cells, APCs, receive maturation signals. Small changes in protein levels significantly alter the cell surface display of MHC class II proteins (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MARCH1 Gene

Protein Domains for MARCH1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TCQ1

UniProtKB/Swiss-Prot:

MARH1_HUMAN :
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
  • Contains 1 RING-CH-type zinc finger.
Domain:
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
Similarity:
  • Contains 1 RING-CH-type zinc finger.
genes like me logo Genes that share domains with MARCH1: view

No data available for Suggested Antigen Peptide Sequences for MARCH1 Gene

Function for MARCH1 Gene

Molecular function for MARCH1 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.
UniProtKB/Swiss-Prot Induction:
By IL10/interleukin-10.

Enzyme Numbers (IUBMB) for MARCH1 Gene

Gene Ontology (GO) - Molecular Function for MARCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 14722266
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0042287 MHC protein binding IDA 18389477
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MARCH1: view
genes like me logo Genes that share phenotypes with MARCH1: view

Animal Models for MARCH1 Gene

MGI Knock Outs for MARCH1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MARCH1 Gene

Localization for MARCH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCH1 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARCH1 gene
Compartment Confidence
plasma membrane 5
lysosome 5
endosome 5
endoplasmic reticulum 4
golgi apparatus 4
mitochondrion 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MARCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA,IDA 14722266
GO:0005765 lysosomal membrane ISS --
GO:0005768 endosome IEA,IDA 14722266
GO:0005789 endoplasmic reticulum membrane ISS --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with MARCH1: view

Pathways & Interactions for MARCH1 Gene

SuperPathways for MARCH1 Gene

No Data Available

UniProtKB/Swiss-Prot Q8TCQ1-MARH1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MARCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 19117940
GO:0002376 immune system process IEA --
GO:0002495 antigen processing and presentation of peptide antigen via MHC class II IDA 18389477
GO:0006955 immune response IDA 18305173
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MARCH1: view

No data available for Pathways by source and SIGNOR curated interactions for MARCH1 Gene

Drugs & Compounds for MARCH1 Gene

(3) Drugs for MARCH1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for MARCH1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with MARCH1: view

Transcripts for MARCH1 Gene

mRNA/cDNA for MARCH1 Gene

(6) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MARCH1 Gene

Membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH1 Gene

No ASD Table

Relevant External Links for MARCH1 Gene

GeneLoc Exon Structure for
MARCH1
ECgene alternative splicing isoforms for
MARCH1

Expression for MARCH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MARCH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MARCH1 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MARCH1 Gene



Protein tissue co-expression partners for MARCH1 Gene

SOURCE GeneReport for Unigene cluster for MARCH1 Gene:

Hs.592804

mRNA Expression by UniProt/SwissProt for MARCH1 Gene:

Q8TCQ1-MARH1_HUMAN
Tissue specificity: Expressed in antigen presenting cells, APCs, located in lymph nodes and spleen. Also expressed in lung. Expression is high in follicular B-cells, moderate in dendritic cells and low in splenic T-cells.
genes like me logo Genes that share expression patterns with MARCH1: view

Primer Products

No data available for mRNA differential expression in normal tissues for MARCH1 Gene

Orthologs for MARCH1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MARCH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARCH1 34 35
  • 99.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MARCH1 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MARCH1 34 35
  • 91.46 (n)
mouse
(Mus musculus)
Mammalia March1 34 16 35
  • 91.35 (n)
cow
(Bos Taurus)
Mammalia MARCH1 34 35
  • 81.38 (n)
oppossum
(Monodelphis domestica)
Mammalia MARCH1 35
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves MARCH1 35
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MARCH1 35
  • 87 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii march1 35
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4080 35
  • 16 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSM4 35
  • 3 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
OneToMany
Species where no ortholog for MARCH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARCH1 Gene

ENSEMBL:
Gene Tree for MARCH1 (if available)
TreeFam:
Gene Tree for MARCH1 (if available)

Paralogs for MARCH1 Gene

Paralogs for MARCH1 Gene

(4) SIMAP similar genes for MARCH1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MARCH1: view

Variants for MARCH1 Gene

Sequence variations from dbSNP and Humsavar for MARCH1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000599 -- 163,980,900(+) TCTAA(C/G)TCTGT intron-variant
rs10001082 -- 164,037,474(+) CTTTA(C/T)CAGCA intron-variant
rs10001272 -- 164,037,687(+) cagta(C/T)gtaaa intron-variant
rs10001526 -- 164,211,815(+) atttt(G/T)agaga intron-variant
rs10001689 -- 163,571,243(+) CCACT(G/T)TCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH1 Gene

Variant ID Type Subtype PubMed ID
dgv1539e212 CNV loss 25503493
dgv1540e212 CNV loss 25503493
dgv1541e212 CNV loss 25503493
dgv1542e212 CNV loss 25503493
dgv2931n106 CNV deletion 24896259
dgv5458n100 CNV gain 25217958
dgv5459n100 CNV loss 25217958
dgv5460n100 CNV gain 25217958
dgv9367n54 CNV loss 21841781
dgv9368n54 CNV loss 21841781
esv1002929 CNV deletion 20482838
esv1471717 CNV insertion 17803354
esv1594178 CNV deletion 17803354
esv1773945 CNV deletion 17803354
esv2184592 CNV deletion 18987734
esv2224163 CNV deletion 18987734
esv22863 CNV loss 19812545
esv2293577 CNV deletion 18987734
esv2453665 CNV deletion 19546169
esv26379 CNV loss 19812545
esv2663902 CNV deletion 23128226
esv2665160 CNV deletion 23128226
esv2665814 CNV deletion 23128226
esv2671056 CNV deletion 23128226
esv2671614 CNV deletion 23128226
esv2672728 CNV deletion 23128226
esv2674636 CNV deletion 23128226
esv2676542 CNV deletion 23128226
esv2677589 CNV deletion 23128226
esv2728666 CNV deletion 23290073
esv2728667 CNV deletion 23290073
esv2728668 CNV deletion 23290073
esv2728669 CNV deletion 23290073
esv2728670 CNV deletion 23290073
esv2728671 CNV deletion 23290073
esv2728672 CNV deletion 23290073
esv2728674 CNV deletion 23290073
esv2728675 CNV deletion 23290073
esv2728676 CNV deletion 23290073
esv2728677 CNV deletion 23290073
esv2728678 CNV deletion 23290073
esv2728679 CNV deletion 23290073
esv2760839 CNV loss 21179565
esv2762472 CNV loss 21179565
esv29373 CNV loss 19812545
esv29511 CNV gain 19812545
esv3297829 CNV deletion 24192839
esv3303597 CNV mobile element insertion 20981092
esv3304345 CNV mobile element insertion 20981092
esv3308638 CNV mobile element insertion 20981092
esv3309308 CNV mobile element insertion 20981092
esv3329057 CNV insertion 20981092
esv3339212 CNV insertion 20981092
esv3371675 CNV insertion 20981092
esv3375283 CNV insertion 20981092
esv3564916 CNV deletion 23714750
esv3564917 CNV deletion 23714750
esv3564918 CNV deletion 23714750
esv3564919 CNV deletion 23714750
esv3564928 CNV deletion 23714750
esv3564929 CNV deletion 23714750
esv3569797 CNV loss 25503493
esv3569801 CNV loss 25503493
esv3575787 CNV gain 25503493
esv3575788 CNV gain 25503493
esv3575789 CNV gain 25503493
esv3602962 CNV loss 21293372
esv3602964 CNV loss 21293372
esv3602966 CNV loss 21293372
esv3602967 CNV loss 21293372
esv3602968 CNV loss 21293372
esv3602969 CNV loss 21293372
esv3602970 CNV loss 21293372
esv3602974 CNV loss 21293372
esv3602975 CNV gain 21293372
esv3602976 CNV loss 21293372
esv3602979 CNV loss 21293372
esv3602980 CNV loss 21293372
esv3602982 CNV loss 21293372
esv3602984 CNV loss 21293372
esv3602985 CNV loss 21293372
esv3602988 CNV loss 21293372
esv3602991 CNV loss 21293372
esv3894065 CNV loss 25118596
esv4777 CNV loss 18987735
esv6963 CNV loss 19470904
esv992191 CNV deletion 20482838
esv993008 CNV deletion 20482838
esv995521 CNV deletion 20482838
nsv1019140 CNV gain 25217958
nsv1019387 CNV gain 25217958
nsv1026744 CNV gain 25217958
nsv1029451 CNV loss 25217958
nsv1030184 CNV loss 25217958
nsv1074233 CNV deletion 25765185
nsv1074234 CNV deletion 25765185
nsv1114594 CNV deletion 24896259
nsv1117401 CNV tandem duplication 24896259
nsv1123861 CNV deletion 24896259
nsv1126049 CNV deletion 24896259
nsv1131837 CNV deletion 24896259
nsv1139326 CNV deletion 24896259
nsv1139822 CNV duplication 24896259
nsv1148331 CNV deletion 26484159
nsv1152187 CNV insertion 26484159
nsv1153533 CNV deletion 26484159
nsv292001 CNV deletion 16902084
nsv293053 CNV deletion 16902084
nsv436419 CNV deletion 17901297
nsv4586 CNV insertion 18451855
nsv4588 CNV deletion 18451855
nsv474278 CNV novel sequence insertion 20440878
nsv476552 CNV novel sequence insertion 20440878
nsv477493 CNV novel sequence insertion 20440878
nsv509943 OTHER sequence alteration 20534489
nsv513174 CNV loss 21212237
nsv521840 CNV loss 19592680
nsv525419 CNV loss 19592680
nsv526583 CNV gain 19592680
nsv596024 CNV loss 21841781
nsv596025 CNV loss 21841781
nsv818295 CNV loss 17921354
nsv819593 CNV gain 19587683
nsv821217 CNV deletion 20802225
nsv822813 CNV loss 20364138
nsv822814 CNV gain+loss 20364138
nsv830138 CNV gain 17160897
nsv955647 CNV deletion 24416366
nsv956381 CNV deletion 24416366
nsv958227 CNV deletion 24416366
nsv964107 CNV duplication 23825009
nsv964108 CNV duplication 23825009
nsv966334 CNV duplication 23825009
nsv966335 CNV duplication 23825009
nsv966375 CNV duplication 23825009
nsv966562 CNV deletion 23825009
nsv967846 CNV duplication 23825009
nsv980269 CNV duplication 23825009
nsv980270 CNV duplication 23825009
nsv980497 CNV deletion 23825009

Variation tolerance for MARCH1 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MARCH1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MARCH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH1 Gene

Disorders for MARCH1 Gene

Relevant External Links for MARCH1

Genetic Association Database (GAD)
MARCH1
Human Genome Epidemiology (HuGE) Navigator
MARCH1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MARCH1

No disorders were found for MARCH1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MARCH1 Gene

Publications for MARCH1 Gene

  1. MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. (PMID: 18305173) De Gassart A. … Gatti E. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 22 64
  2. Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes. (PMID: 18389477) Thibodeau J. … Steimle V. (Eur. J. Immunol. 2008) 3 4 22 64
  3. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E. … Frueh K. (J. Virol. 2004) 2 3 4 64
  4. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PMID: 21490949) Sim X. … Tai E.S. (PLoS Genet. 2011) 3 46 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for MARCH1 Gene

Sources for MARCH1 Gene

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