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Aliases for MARCH1 Gene

Aliases for MARCH1 Gene

  • Membrane Associated Ring-CH-Type Finger 1 2 3 5
  • Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase 2 3
  • Membrane-Associated RING Finger Protein 1 3 4
  • Membrane-Associated RING-CH Protein I 3 4
  • RING Finger Protein 171 3 4
  • MARCH-I 3 4
  • RNF171 3 4
  • Membrane-Associated Ring Finger (C3HC4) 1 2
  • Membrane Associated Ring Finger 1 3
  • EC 6.3.2.- 4
  • EC 6.3.2 63

External Ids for MARCH1 Gene

Previous GeneCards Identifiers for MARCH1 Gene

  • GC04M164806
  • GC04M164668
  • GC04M164448
  • GC04M160199

Summaries for MARCH1 Gene

Entrez Gene Summary for MARCH1 Gene

  • MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010]

GeneCards Summary for MARCH1 Gene

MARCH1 (Membrane Associated Ring-CH-Type Finger 1) is a Protein Coding gene. GO annotations related to this gene include ligase activity and MHC protein binding. An important paralog of this gene is MARCH6.

UniProtKB/Swiss-Prot for MARCH1 Gene

  • E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCH1 Gene

Genomics for MARCH1 Gene

Regulatory Elements for MARCH1 Gene

Enhancers for MARCH1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MARCH1 on UCSC Golden Path with GeneCards custom track

Promoters for MARCH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MARCH1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MARCH1 Gene

Chromosome:
4
Start:
163,524,298 bp from pter
End:
164,384,050 bp from pter
Size:
859,753 bases
Orientation:
Minus strand

Genomic View for MARCH1 Gene

Genes around MARCH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCH1 Gene

Proteins for MARCH1 Gene

  • Protein details for MARCH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCQ1-MARH1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MARCH1
    Protein Accession:
    Q8TCQ1
    Secondary Accessions:
    • D3DP29
    • Q9NWR0

    Protein attributes for MARCH1 Gene

    Size:
    289 amino acids
    Molecular mass:
    32308 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MARCH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARCH1 Gene

Proteomics data for MARCH1 Gene at MOPED

Selected DME Specific Peptides for MARCH1 Gene

Post-translational modifications for MARCH1 Gene

  • Has a short half-life. Instability/short half-life permits rapid changes that allow efficient induction of antigen presentation once antigen presenting cells, APCs, receive maturation signals. Small changes in protein levels significantly alter the cell surface display of MHC class II proteins (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MARCH1 Gene

Domains & Families for MARCH1 Gene

Protein Domains for MARCH1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TCQ1

UniProtKB/Swiss-Prot:

MARH1_HUMAN :
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
  • Contains 1 RING-CH-type zinc finger.
Domain:
  • The RING-CH-type zinc finger domain is required for E3 ligase activity.
Similarity:
  • Contains 1 RING-CH-type zinc finger.
genes like me logo Genes that share domains with MARCH1: view

No data available for Suggested Antigen Peptide Sequences for MARCH1 Gene

Function for MARCH1 Gene

Molecular function for MARCH1 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.
UniProtKB/Swiss-Prot Induction:
By IL10/interleukin-10.

Enzyme Numbers (IUBMB) for MARCH1 Gene

Gene Ontology (GO) - Molecular Function for MARCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 14722266
GO:0016874 ligase activity IEA --
GO:0061630 ubiquitin protein ligase activity IEA --
genes like me logo Genes that share ontologies with MARCH1: view
genes like me logo Genes that share phenotypes with MARCH1: view

Animal Models for MARCH1 Gene

MGI Knock Outs for MARCH1:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MARCH1 Gene

Localization for MARCH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCH1 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MARCH1 Gene COMPARTMENTS Subcellular localization image for MARCH1 gene
Compartment Confidence
endosome 5
lysosome 5
plasma membrane 5
vacuole 5
endoplasmic reticulum 4
golgi apparatus 4
cytosol 2
mitochondrion 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MARCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 14722266
GO:0005765 lysosomal membrane ISS --
GO:0005768 endosome IDA 14722266
GO:0031901 early endosome membrane IDA 19117940
GO:0031902 late endosome membrane IDA 19117940
genes like me logo Genes that share ontologies with MARCH1: view

Pathways & Interactions for MARCH1 Gene

SuperPathways for MARCH1 Gene

No Data Available

UniProtKB/Swiss-Prot Q8TCQ1-MARH1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MARCH1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MARCH1 Gene

Drugs & Compounds for MARCH1 Gene

(3) Drugs for MARCH1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for MARCH1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with MARCH1: view

Transcripts for MARCH1 Gene

mRNA/cDNA for MARCH1 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MARCH1 Gene

Membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MARCH1 Gene

No ASD Table

Relevant External Links for MARCH1 Gene

GeneLoc Exon Structure for
MARCH1
ECgene alternative splicing isoforms for
MARCH1

Expression for MARCH1 Gene

mRNA expression in normal human tissues for MARCH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MARCH1 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MARCH1 Gene



SOURCE GeneReport for Unigene cluster for MARCH1 Gene Hs.592804

mRNA Expression by UniProt/SwissProt for MARCH1 Gene

Q8TCQ1-MARH1_HUMAN
Tissue specificity: Expressed in antigen presenting cells, APCs, located in lymph nodes and spleen. Also expressed in lung. Expression is high in follicular B-cells, moderate in dendritic cells and low in splenic T-cells.
genes like me logo Genes that share expression patterns with MARCH1: view

Protein tissue co-expression partners for MARCH1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MARCH1 Gene

Orthologs for MARCH1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MARCH1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MARCH1 35
  • 81.38 (n)
  • 86.64 (a)
MARCH1 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MARCH1 35
  • 91.46 (n)
  • 96.54 (a)
MARCH1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia March1 35
  • 91.35 (n)
  • 95.44 (a)
March1 16
March1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MARCH1 35
  • 99.08 (n)
  • 99.31 (a)
MARCH1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MARCH1 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MARCH1 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves MARCH1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MARCH1 36
  • 87 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii march1 36
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4080 36
  • 16 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSM4 36
  • 3 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for MARCH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARCH1 Gene

ENSEMBL:
Gene Tree for MARCH1 (if available)
TreeFam:
Gene Tree for MARCH1 (if available)

Paralogs for MARCH1 Gene

Paralogs for MARCH1 Gene

(4) SIMAP similar genes for MARCH1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MARCH1: view

Variants for MARCH1 Gene

Sequence variations from dbSNP and Humsavar for MARCH1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs4722 -- 163,933,172(+) TCATG(C/T)AGTTG intron-variant
rs16853 -- 163,643,623(+) TTTGT(A/G)TAAGT intron-variant
rs877210 -- 163,623,169(-) TCTGC(A/G)CTGCC intron-variant
rs978401 -- 163,858,999(-) TGAAC(A/T)TCTCT intron-variant
rs978402 -- 163,858,968(-) ATCCT(A/G)CTTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARCH1 Gene

Variant ID Type Subtype PubMed ID
nsv4586 CNV Insertion 18451855
esv2293577 CNV Deletion 18987734
esv4777 CNV Deletion 18987735
esv2728666 CNV Deletion 23290073
esv2663902 CNV Deletion 23128226
esv6963 CNV Loss 19470904
nsv292001 CNV Loss 16902084
esv995521 CNV Deletion 20482838
esv1594178 CNV Deletion 17803354
esv2453665 CNV Deletion 19546169
esv2728667 CNV Deletion 23290073
esv2224163 CNV Deletion 18987734
esv2728668 CNV Deletion 23290073
esv2671614 CNV Deletion 23128226
esv1773945 CNV Deletion 17803354
esv2728669 CNV Deletion 23290073
esv2676542 CNV Deletion 23128226
esv26379 CNV Loss 19812545
nsv818295 CNV Loss 17921354
nsv513174 CNV Loss 21212237
esv2728670 CNV Deletion 23290073
esv2665814 CNV Deletion 23128226
nsv293053 CNV Loss 16902084
esv992191 CNV Deletion 20482838
nsv881156 CNV Loss 21882294
nsv830138 CNV Gain 17160897
esv2674636 CNV Deletion 23128226
esv1471717 CNV Insertion 17803354
esv268624 CNV Insertion 20981092
nsv525419 CNV Loss 19592680
esv272911 CNV Insertion 20981092
nsv436419 CNV Deletion 17901297
esv2665160 CNV Deletion 23128226
esv22863 CNV Loss 19812545
esv2728671 CNV Deletion 23290073
esv2728672 CNV Deletion 23290073
esv2728674 CNV Deletion 23290073
esv2728675 CNV Deletion 23290073
esv2728676 CNV Deletion 23290073
nsv521840 CNV Loss 19592680
nsv509943 CNV Loss 20534489
dgv5816n71 CNV Loss 21882294
nsv4588 CNV Loss 18451855
nsv881073 CNV Loss 21882294
nsv881505 CNV Loss 21882294
dgv5817n71 CNV Loss 21882294
nsv880412 CNV Loss 21882294
esv267876 CNV Insertion 20981092
esv273581 CNV Insertion 20981092
esv29373 CNV Loss 19812545
esv2671056 CNV Deletion 23128226
nsv526583 CNV Gain 19592680
nsv821217 CNV Deletion 20802225
nsv822813 CNV Loss 20364138
esv29511 CNV Gain 19812545
nsv819593 CNV Gain 19587683
nsv822814 CNV Gain+Loss 20364138
esv2672728 CNV Deletion 23128226
esv2728677 CNV Deletion 23290073
esv2677589 CNV Deletion 23128226
esv2728678 CNV Deletion 23290073
esv2184592 CNV Deletion 18987734
esv2728679 CNV Deletion 23290073
esv1002929 CNV Deletion 20482838
esv993008 CNV Deletion 20482838

Variation tolerance for MARCH1 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MARCH1 Gene

HapMap Linkage Disequilibrium report
MARCH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCH1 Gene

Disorders for MARCH1 Gene

Relevant External Links for MARCH1

Genetic Association Database (GAD)
MARCH1
Human Genome Epidemiology (HuGE) Navigator
MARCH1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MARCH1

No disorders were found for MARCH1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MARCH1 Gene

Publications for MARCH1 Gene

  1. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. (PMID: 14722266) Bartee E. … Frueh K. (J. Virol. 2004) 2 3 4 67
  2. MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. (PMID: 18305173) De Gassart A. … Gatti E. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23
  3. Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes. (PMID: 18389477) Thibodeau J. … Steimle V. (Eur. J. Immunol. 2008) 3 23
  4. Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis. (PMID: 24578125) Olden M. … Devuyst O. (J. Am. Soc. Nephrol. 2014) 3
  5. Identification of a novel motif that affects the conformation and activity of the MARCH1 E3 ubiquitin ligase. (PMID: 23264739) Bourgeois-Daigneault M.C. … Thibodeau J. (J. Cell. Sci. 2013) 3

Products for MARCH1 Gene

Sources for MARCH1 Gene

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