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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MARC2 Gene

protein-coding   GIFtS: 47
GCID: GC01P220922

Mitochondrial Amidoxime Reducing Component 2

(Previous name: MOCO sulphurase C-terminal domain containing 2)
(Previous symbol: MOSC2)
  Search for MARC2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrial Amidoxime Reducing Component 21 2 3     RP11-270A6.12
MOSC21 2 3     MOSC Domain-Containing Protein 2, Mitochondrial2
MOCO Sulphurase C-Terminal Domain Containing 21 2     EC 1.-.-.-3
Moco Sulfurase C-Terminal Domain-Containing Protein 22 3     mARC23
Molybdenum Cofactor Sulfurase C-Terminal Domain-Containing Protein 22 3     

External Ids:    HGNC: 260641   Entrez Gene: 549962   Ensembl: ENSG000001177917   OMIM: 6141275   UniProtKB: Q969Z33   

Export aliases for MARC2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MARC2 Gene: 
MARC2 (mitochondrial amidoxime reducing component 2) is a protein-coding gene. GO annotations related to this gene include molybdenum ion binding and pyridoxal phosphate binding. An important paralog of this gene is MARC1.

UniProtKB/Swiss-Prot: MOSC2_HUMAN, Q969Z3
Function: As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated
prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and
N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively

Gene Wiki entry for MARC2 (MOSC2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MARC2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMARC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MARC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q41

MARC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARC2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P220922:  view genomic region     (about GC identifiers)

Start:
220,921,567 bp from pter      End:
220,958,150 bp from pter
Size:
36,584 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MOSC2_HUMAN, Q969Z3 (See protein sequence)
Recommended Name: MOSC domain-containing protein 2, mitochondrial precursor  
Size: 335 amino acids; 38023 Da
Cofactor: Molybdenum (Probable)
Subunit: Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MOSC2 (By
similarity)
Subcellular location: Mitochondrion outer membrane; Peripheral membrane protein. Peroxisome (By similarity)
Sequence caution: Sequence=BAA91287.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAH70306.1; Type=Erroneous gene model prediction; Sequence=CAH71880.1; Type=Erroneous gene model
prediction;
Secondary accessions: B2D0R5 D3DTB3 Q0JSK7 Q5VT67 Q5VXC7 Q7L317 Q9H066 Q9NWU0
Alternative splicing: 2 isoforms:  Q969Z3-1   Q969Z3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MARC2: NX_Q969Z3

Explore proteomics data for MARC2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q969Z3

  • MARC2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MARC2 Protein Expression
    REFSEQ proteins: NP_060368.2  
    ENSEMBL proteins: 
     ENSP00000435450   ENSP00000352266   ENSP00000355880   ENSP00000416442  

    Human Recombinant Protein Products for MARC2: 
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    OriGene MassSpec for MARC2 
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    GenScript Custom Purified and Recombinant Proteins Services for MARC2
    Novus Biologicals MARC2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS--
    GO:0005741mitochondrial outer membrane IEA--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005777peroxisome IEA--

    MARC2 for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR005303 MOSC_N
     IPR005302 MoCF_Sase_C
     IPR011037 Pyrv_Knase-like_insert_dom

    Graphical View of Domain Structure for InterPro Entry Q969Z3

    ProtoNet protein and cluster: Q969Z3

    1 Blocks protein domain: IPB005302 MOSC domain

    UniProtKB/Swiss-Prot: MOSC2_HUMAN, Q969Z3
    Similarity: Contains 1 MOSC domain


    MARC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOSC2_HUMAN, Q969Z3
    Function: As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated
    prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and
    N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively
    Biophysicochemical properties: Kinetic parameters: KM=830 uM for benzamidoxime; KM=3 mM for NOHA; KM=3.7 mM for
    NHAM; Vmax=307 nmol/min/mg enzyme toward benzamidoxime; Vmax=373 nmol/min/mg enzyme toward NOHA; Vmax=36.5
    nmol/min/mg enzyme toward NHAM;

         Enzyme Number (IUBMB): EC 1.-.-.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0008940nitrate reductase activity IDA--
    GO:0030151molybdenum ion binding IDA--
    GO:0030170pyridoxal phosphate binding IEA--
    GO:0043546molybdopterin cofactor binding IDA--
         
    MARC2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MARC2:
     Decreased circadian period len 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Marc2):
     adipose tissue  behavior/neurological  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system 

    MARC2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MARC2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MARC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MARC2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MARC2 

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MARC2
    SwitchGear 3'UTR luciferase reporter plasmidMARC2 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARC2
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                         Customized lentivirus expression plasmids for stable overexpression of MARC2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARC2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MARC2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for MARC2 (Q969Z33 ENSP000003558804) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319463I2D: score=1 
    NDUFS2ENSP000003569724STRING: ENSP00000356972
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042126nitrate metabolic process IDA--
    GO:0051410detoxification of nitrogen compound NAS--
    GO:0055114oxidation-reduction process IDA--

    MARC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MARC2 (MOSC2)

    Search CenterWatch for drugs/clinical trials and news about MARC2 / MOSC2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MARC2 gene: 
    NM_017898.3  

    Unigene Cluster for MARC2:

    Mitochondrial amidoxime reducing component 2
    Hs.369042  [show with all ESTs]
    Unigene Representative Sequence: AK125512
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469583 ENST00000359316 ENST00000366913(uc001hmq.3 uc001hmr.3 uc009xdx.3)
    ENST00000425560 ENST00000496078 ENST00000472447
    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MARC2
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    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MARC2
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    Sirion Biotech Customized lentivirus for stable overexpression of MARC2 
                         Customized lentivirus expression plasmids for stable overexpression of MARC2 
    Primer
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    OriGene qPCR primer pairs and template standards for MARC2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARC2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARC2

    Additional mRNA sequence: 

    AK000583.1 AK000612.1 AK125512.1 AL136931.1 BC010366.1 BC011973.1 BC015829.2 BC016859.1 

    5 DOTS entries:

    DT.215529  DT.101958880  DT.92425176  DT.86840490  DT.92425177 

    24/144 AceView cDNA sequences (see all 144):

    AI379634 AI570738 AA779383 AI283785 AI572411 CA394968 BQ889002 AI080050 
    AI522268 AI457991 AI650791 BC011973 CA312814 CB267441 NM_017898 AI400354 
    AL136931 AA704232 AA854382 CB161890 AK000612 BE046902 AA677965 AI422191 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MARC2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c
    SP1:                          -                                   -     -           -                                 
    SP2:                          -                                   -     -           -                                 
    SP3:                                                                    -           -                                 
    SP4:                    -     -                                                                                       
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for MARC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MARC2 expression in normal human tissues (normalized intensities)      MARC2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTATTACAC
    MARC2 Expression
    About this image


    MARC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             seminal vesicle ; glandular cells   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             liver ; bile duct cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             colon ; endothelial cells   
     
     Uterus (Reproductive System)    fully expand to see all 2 entries
             uterus, post-menopause ; glandular cells   
     
     Thyroid (Endocrine System)    fully expand to see all 2 entries
             thyroid gland ; glandular cells   

    See MARC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MARC2

    SOURCE GeneReport for Unigene cluster: Hs.369042
        SABiosciences Custom PCR Arrays for MARC2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MARC2 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Marc25
    Mosc21
    MOCO sulphurase C-terminal domain containing 21, 5 79.2(n)1
    75.22(a)1
      1 (89.12 cM)5
    672471  NM_133684.31  NP_598445.11 
     1848130685 
    chicken
    (Gallus gallus)
    Aves MARC21 mitochondrial amidoxime reducing component 2 68.05(n)
    62.42(a)
      428563  XM_426119.2  XP_426119.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    --

    57(a)
    (see all 4)
    possible ortholog
    many ↔ many
    (see all 4)
    GL344100.1(36229-61934)
    1(243573954-243586585)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1107831 zgc:110783 55.7(n)
    48.68(a)
      378742  NM_001014367.1  NP_001014389.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG16656
    --
    23(a)
    1 → many
    2R(5727283-5728667)
    worm
    (Caenorhabditis elegans)
    Secernentea F56A11.56
    F22B8.76
    (see all 3)
    Protein F22B8.7
    (see all 3)
    30(a)
    28(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    IV(568373-570843)
    V(16095224-16097320)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G447201 molybdenum cofactor sulfurase family protein 45.98(n)
    37.07(a)
      834501  NM_123839.3  NP_199285.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g05608001 hypothetical protein 45.11(n)
    34.21(a)
      4347854  NM_001070465.1  NP_001063930.1 


    ENSEMBL Gene Tree for MARC2 (if available)
    TreeFam Gene Tree for MARC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MARC2 gene
    MARC12  MOCOS2  
    1 SIMAP similar gene for MARC2 using alignment to 2 protein entries:     MOSC2_HUMAN (see all proteins):
    MARC1

    MARC2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MARC2
    PGOHUM00000237925


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1071 SNPs in MARC2 are shown (see all 1071)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0622754
    ----see VAR_0622752 A S mis40--------
    rs1505647881,2
    --220919703(+) ACTCCC/TGCCAC 1 -- us2k10--------
    rs741398921,2
    C,F--220919809(+) TGCACG/ATGCTG 1 -- us2k12Minor allele frequency- A:0.04WA 120
    rs1906120261,2
    --220919886(+) CCAAAC/GCTCCG 1 -- us2k10--------
    rs121336631,2
    C,F,A,H--220920083(+) AGGACG/AAAGCC 1 -- us2k114Minor allele frequency- A:0.03NS EA NA 1182
    rs724723641,2
    C,F--220920305(+) ACACCA/CTGCTT 1 -- us2k17Minor allele frequency- C:0.01NS NA 310
    rs127385661,2
    C,F--220920374(+) GGACTA/GATTCT 1 -- us2k18Minor allele frequency- G:0.03NA NS 312
    rs118006541,2
    C,F,H--220920386(+) CTGGCC/TTGAGG 1 -- us2k17Minor allele frequency- T:0.03NS NA WA 306
    rs1829647581,2
    C--220920492(+) CTTCCC/TGGAGT 1 -- us2k10--------
    rs724723651,2
    C,F--220920518(+) AGAACG/CGGCCC 1 -- us2k19Minor allele frequency- C:0.06NS NA WA EA 550

    HapMap Linkage Disequilibrium report for MARC2 (220921567 - 220958150 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MARC2: --
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MARC2 for disorders           About MalaCards
    OMIM gene information: 614127    OMIM disorders: --


    MARC2 for disorders           About GeneDecksing


    Export disorders for MARC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MARC2 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with MARC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Reduction of N(I8)-hydroxy-L-arginine by the mitochond rial amidoxime reducing component (mARC). (PubMed id 21029045)1, 2 Kotthaus J....Clement B. (2010)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases. (PubMed id 11886751)1, 3 Anantharaman V. and Aravind L. (2002)
    6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    7. The involvement of mitochondrial amidoxime reducing co mponents 1 and 2 and mitochondrial cytochrome b5 in N-reductive metabolism in hu man cells. (PubMed id 23703616)1 Plitzko B....Havemeyer A. (2013)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Structural studies of the molybdenum center of mitoch ondrial amidoxime reducing component (mARC) by pulsed EPR spectroscopy and 17O- labeling. (PubMed id 21916412)1 Rajapakshe A....Enemark J.H. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54996 HGNC: 26064 AceView: FLJ20605 Ensembl:ENSG00000117791 euGenes: HUgn54996
    ECgene: MARC2 H-InvDB: MARC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MARC2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mosc2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MARC2 gene:
    Search GeneIP for patents involving MARC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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