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Aliases for MARC2 Gene

Aliases for MARC2 Gene

  • Mitochondrial Amidoxime Reducing Component 2 2 3
  • Molybdenum Cofactor Sulfurase C-Terminal Domain-Containing Protein 2 3 4
  • Moco Sulfurase C-Terminal Domain-Containing Protein 2 3 4
  • MOCO Sulphurase C-Terminal Domain Containing 2 2 3
  • MOSC2 3 4
  • MOSC Domain-Containing Protein 2, Mitochondrial 3
  • MOSC Domain-Containing Protein 2 4
  • EC 1.-.-.- 4
  • MOSC2, 6
  • MARC2 4

External Ids for MARC2 Gene

Previous HGNC Symbols for MARC2 Gene

  • MOSC2

Previous GeneCards Identifiers for MARC2 Gene

  • GC01P220922

Summaries for MARC2 Gene

GeneCards Summary for MARC2 Gene

MARC2 (Mitochondrial Amidoxime Reducing Component 2) is a Protein Coding gene. GO annotations related to this gene include pyridoxal phosphate binding and molybdenum ion binding. An important paralog of this gene is MARC1.

UniProtKB/Swiss-Prot for MARC2 Gene

  • As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively.

Gene Wiki entry for MARC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARC2 Gene

Genomics for MARC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MARC2 Gene

Start:
220,747,987 bp from pter
End:
220,784,815 bp from pter
Size:
36,829 bases
Orientation:
Plus strand

Genomic View for MARC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARC2 Gene

No data available for Regulatory Elements for MARC2 Gene

Proteins for MARC2 Gene

  • Protein details for MARC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969Z3-MARC2_HUMAN
    Recommended name:
    Mitochondrial amidoxime reducing component 2
    Protein Accession:
    Q969Z3
    Secondary Accessions:
    • B2D0R5
    • D3DTB3
    • Q0JSK7
    • Q5VT67
    • Q5VXC7
    • Q7L317
    • Q9H066
    • Q9NWU0

    Protein attributes for MARC2 Gene

    Size:
    335 amino acids
    Molecular mass:
    38023 Da
    Cofactor:
    Name=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302; Note=Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.;
    Quaternary structure:
    • Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MARC2.
    SequenceCaution:
    • Sequence=BAA91287.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH70306.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH71880.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MARC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARC2 Gene

Proteomics data for MARC2 Gene at MOPED

Post-translational modifications for MARC2 Gene

  • Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
  • Ubiquitination at Lys59, Lys156, Lys166, and Lys173
  • Modification sites at PhosphoSitePlus

Other Protein References for MARC2 Gene

No data available for DME Specific Peptides for MARC2 Gene

Domains for MARC2 Gene

Protein Domains for MARC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q969Z3

UniProtKB/Swiss-Prot:

MARC2_HUMAN :
  • Q969Z3
Domain:
  • Contains 1 MOSC domain.
genes like me logo Genes that share domains with MARC2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MARC2 Gene

Function for MARC2 Gene

Molecular function for MARC2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=830 uM for benzamidoxime {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; KM=400 uM for benzamidoxime (PubMed:24423752, at pH 6.0 and 37 degrees Celsius) {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; KM=3 mM for NOHA {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; KM=3.7 mM for NHAM {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; Vmax=307 nmol/min/mg enzyme toward benzamidoxime {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; Vmax=119 nmol/min/mg enzyme toward benzamidoxime (PubMed:24423752, at pH 6.0 and 37 degrees Celsius) {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; Vmax=373 nmol/min/mg enzyme toward NOHA {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; Vmax=36.5 nmol/min/mg enzyme toward NHAM {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752};
UniProtKB/Swiss-Prot Function: As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively.

Enzyme Numbers (IUBMB) for MARC2 Gene

Gene Ontology (GO) - Molecular Function for MARC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0008940 nitrate reductase activity IDA 20861021
GO:0030151 molybdenum ion binding IDA 20861021
GO:0030170 pyridoxal phosphate binding IEA --
GO:0043546 molybdopterin cofactor binding IDA 20861021
genes like me logo Genes that share ontologies with MARC2: view
genes like me logo Genes that share phenotypes with MARC2: view

Animal Model Products

CRISPR Products

miRNA for MARC2 Gene

miRTarBase miRNAs that target MARC2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MARC2 Gene

Localization for MARC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARC2 Gene

Mitochondrion outer membrane; Peripheral membrane protein. Peroxisome.

Gene Ontology (GO) - Cellular Components for MARC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0005741 mitochondrial outer membrane IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005777 peroxisome IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MARC2: view

No data available for Subcellular locations from COMPARTMENTS for MARC2 Gene

Pathways for MARC2 Gene

SuperPathways for MARC2 Gene

No Data Available

Interacting Proteins for MARC2 Gene

Gene Ontology (GO) - Biological Process for MARC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0042126 nitrate metabolic process IDA 20861021
GO:0051410 detoxification of nitrogen compound NAS 20861021
GO:0055114 oxidation-reduction process IDA 20861021
genes like me logo Genes that share ontologies with MARC2: view

No data available for Pathways by source for MARC2 Gene

Transcripts for MARC2 Gene

Unigene Clusters for MARC2 Gene

Mitochondrial amidoxime reducing component 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MARC2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARC2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5:
SP6: - -
SP7:

Relevant External Links for MARC2 Gene

GeneLoc Exon Structure for
MARC2
ECgene alternative splicing isoforms for
MARC2

Expression for MARC2 Gene

mRNA expression in normal human tissues for MARC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MARC2 Gene

This gene is overexpressed in Liver (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MARC2 Gene

SOURCE GeneReport for Unigene cluster for MARC2 Gene Hs.369042

genes like me logo Genes that share expressions with MARC2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MARC2 Gene

Orthologs for MARC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MARC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOSC2 35
  • 98.91 (n)
  • 99.1 (a)
MOSC2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MARC2 36
  • 79 (a)
OneToOne
MOSC2 35
  • 83.78 (n)
  • 79.4 (a)
dog
(Canis familiaris)
Mammalia MARC2 35
  • 82.51 (n)
  • 77.05 (a)
MARC2 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Marc2 35
  • 79.2 (n)
  • 75.22 (a)
Marc2 16
Marc2 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MARC2 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MARC2 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910481 35
  • 79.2 (n)
  • 74.93 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia marc1 35
  • 56.61 (n)
  • 49.82 (a)
zebrafish
(Danio rerio)
Actinopterygii MARC2 36
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1665 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F22B8.7 36
  • 29 (a)
ManyToMany
F53E10.1 36
  • 28 (a)
ManyToMany
F56A11.5 36
  • 30 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G44720 35
  • 46.12 (n)
  • 37.07 (a)
rice
(Oryza sativa)
Liliopsida Os09g0560800 35
  • 45.65 (n)
  • 33.58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
OneToMany
Species with no ortholog for MARC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARC2 Gene

ENSEMBL:
Gene Tree for MARC2 (if available)
TreeFam:
Gene Tree for MARC2 (if available)

Paralogs for MARC2 Gene

Paralogs for MARC2 Gene

Selected SIMAP similar genes for MARC2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MARC2 Gene

genes like me logo Genes that share paralogs with MARC2: view

Variants for MARC2 Gene

Sequence variations from dbSNP and Humsavar for MARC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs182872 -- 220,763,078(-) GAGCA(C/T)GATGC intron-variant
rs337137 -- 220,761,514(-) AGAAG(C/T)GCAAG intron-variant
rs337138 -- 220,761,497(-) GAGTA(C/G)AGTGT intron-variant
rs337139 -- 220,760,735(-) atttg(G/T)tttgt intron-variant
rs337140 -- 220,760,584(-) gaaat(C/T)aaatg intron-variant

Relevant External Links for MARC2 Gene

HapMap Linkage Disequilibrium report
MARC2
Human Gene Mutation Database (HGMD)
MARC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MARC2 Gene

Disorders for MARC2 Gene

No disorders were found for MARC2 Gene.

No data available for UniProtKB/Swiss-Prot for MARC2 Gene

Publications for MARC2 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  2. MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases. (PMID: 11886751) Anantharaman V. … Aravind L. (FEMS Microbiol. Lett. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for MARC2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MARC2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MARC2
    • Block miRNA regulation of MARC2 using miScript Target Protectors

    Sources for MARC2 Gene

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