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Aliases for MARC2 Gene

Aliases for MARC2 Gene

  • Mitochondrial Amidoxime Reducing Component 2 2 3 5
  • Molybdenum Cofactor Sulfurase C-Terminal Domain-Containing Protein 2 3 4
  • Moco Sulfurase C-Terminal Domain-Containing Protein 2 3 4
  • MOCO Sulphurase C-Terminal Domain Containing 2 2 3
  • MOSC2 3 4
  • MOSC Domain-Containing Protein 2, Mitochondrial 3
  • MOSC Domain-Containing Protein 2 4
  • EC 1.-.-.- 4
  • MARC2 4

External Ids for MARC2 Gene

Previous HGNC Symbols for MARC2 Gene

  • MOSC2

Previous GeneCards Identifiers for MARC2 Gene

  • GC01P220922

Summaries for MARC2 Gene

Entrez Gene Summary for MARC2 Gene

  • The protein encoded by this gene is an enzyme found in the outer mitochondrial membrane that reduces N-hydroxylated substrates. The encoded protein uses molybdenum as a cofactor and cytochrome b5 type B and NADH cytochrome b5 reductase as accessory proteins. One type of substrate used is N-hydroxylated nucleotide base analogues, which can be toxic to a cell. Other substrates include N(omega)-hydroxy-L-arginine (NOHA) and amidoxime prodrugs, which are activated by the encoded enzyme. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for MARC2 Gene

MARC2 (Mitochondrial Amidoxime Reducing Component 2) is a Protein Coding gene. GO annotations related to this gene include pyridoxal phosphate binding and molybdenum ion binding. An important paralog of this gene is MARC1.

UniProtKB/Swiss-Prot for MARC2 Gene

  • As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively.

Gene Wiki entry for MARC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARC2 Gene

Genomics for MARC2 Gene

Regulatory Elements for MARC2 Gene

Enhancers for MARC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MARC2 on UCSC Golden Path with GeneCards custom track

Promoters for MARC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MARC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MARC2 Gene

Chromosome:
1
Start:
220,747,502 bp from pter
End:
220,784,815 bp from pter
Size:
37,314 bases
Orientation:
Plus strand

Genomic View for MARC2 Gene

Genes around MARC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARC2 Gene

Proteins for MARC2 Gene

  • Protein details for MARC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969Z3-MARC2_HUMAN
    Recommended name:
    Mitochondrial amidoxime reducing component 2
    Protein Accession:
    Q969Z3
    Secondary Accessions:
    • B2D0R5
    • D3DTB3
    • Q0JSK7
    • Q5VT67
    • Q5VXC7
    • Q7L317
    • Q9H066
    • Q9NWU0

    Protein attributes for MARC2 Gene

    Size:
    335 amino acids
    Molecular mass:
    38023 Da
    Cofactor:
    Name=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302;
    Quaternary structure:
    • Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MARC2.
    SequenceCaution:
    • Sequence=BAA91287.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH70306.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH71880.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MARC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARC2 Gene

Proteomics data for MARC2 Gene at MOPED

Post-translational modifications for MARC2 Gene

  • Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
  • Ubiquitination at Lys 59, Lys 138, Lys 144, Lys 166, Lys 173, Lys 187, Lys 287, and Lys 294
  • Modification sites at PhosphoSitePlus

Other Protein References for MARC2 Gene

No data available for DME Specific Peptides for MARC2 Gene

Domains & Families for MARC2 Gene

Protein Domains for MARC2 Gene

Suggested Antigen Peptide Sequences for MARC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969Z3

UniProtKB/Swiss-Prot:

MARC2_HUMAN :
  • Contains 1 MOSC domain.
Domain:
  • Contains 1 MOSC domain.
genes like me logo Genes that share domains with MARC2: view

No data available for Gene Families for MARC2 Gene

Function for MARC2 Gene

Molecular function for MARC2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=830 uM for benzamidoxime {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; KM=400 uM for benzamidoxime (at pH 6.0 and 37 degrees Celsius) {ECO:0000269 PubMed:24423752}; KM=3 mM for NOHA {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; KM=3.7 mM for NHAM {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; Vmax=307 nmol/min/mg enzyme toward benzamidoxime {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; Vmax=119 nmol/min/mg enzyme toward benzamidoxime (at pH 6.0 and 37 degrees Celsius) {ECO:0000269 PubMed:24423752}; Vmax=373 nmol/min/mg enzyme toward NOHA {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; Vmax=36.5 nmol/min/mg enzyme toward NHAM {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752};
UniProtKB/Swiss-Prot Function:
As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively.

Enzyme Numbers (IUBMB) for MARC2 Gene

Gene Ontology (GO) - Molecular Function for MARC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030151 molybdenum ion binding IEA,IDA 20861021
genes like me logo Genes that share ontologies with MARC2: view
genes like me logo Genes that share phenotypes with MARC2: view

Animal Models for MARC2 Gene

MGI Knock Outs for MARC2:

Animal Model Products

  • Taconic Biosciences Mouse Models for MARC2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MARC2 Gene

Localization for MARC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARC2 Gene

Mitochondrion outer membrane; Peripheral membrane protein. Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MARC2 Gene COMPARTMENTS Subcellular localization image for MARC2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 3
peroxisome 3
golgi apparatus 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MARC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005777 peroxisome IEA --
genes like me logo Genes that share ontologies with MARC2: view

Pathways & Interactions for MARC2 Gene

SuperPathways for MARC2 Gene

No Data Available

Interacting Proteins for MARC2 Gene

Gene Ontology (GO) - Biological Process for MARC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042126 nitrate metabolic process IDA 20861021
genes like me logo Genes that share ontologies with MARC2: view

No data available for Pathways by source and SIGNOR curated interactions for MARC2 Gene

Drugs & Compounds for MARC2 Gene

(2) Drugs for MARC2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Molybdenum Pharma 28
NADH Nutra 0
genes like me logo Genes that share compounds with MARC2: view

Transcripts for MARC2 Gene

Unigene Clusters for MARC2 Gene

Mitochondrial amidoxime reducing component 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MARC2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5:
SP6: - -
SP7:

Relevant External Links for MARC2 Gene

GeneLoc Exon Structure for
MARC2
ECgene alternative splicing isoforms for
MARC2

Expression for MARC2 Gene

mRNA expression in normal human tissues for MARC2 Gene

mRNA differential expression in normal tissues according to GTEx for MARC2 Gene

This gene is overexpressed in Liver (x8.8).

Protein differential expression in normal tissues from HIPED for MARC2 Gene

This gene is overexpressed in Liver (19.0) and Kidney (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MARC2 Gene



SOURCE GeneReport for Unigene cluster for MARC2 Gene Hs.369042

genes like me logo Genes that share expression patterns with MARC2: view

Protein tissue co-expression partners for MARC2 Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MARC2 Gene

Orthologs for MARC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MARC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MOSC2 35
  • 83.78 (n)
  • 79.4 (a)
MARC2 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MARC2 35
  • 82.51 (n)
  • 77.05 (a)
MARC2 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Marc2 35
  • 79.2 (n)
  • 75.22 (a)
Marc2 16
Marc2 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MOSC2 35
  • 98.91 (n)
  • 99.1 (a)
MOSC2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910481 35
  • 79.2 (n)
  • 74.93 (a)
oppossum
(Monodelphis domestica)
Mammalia MARC2 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MARC2 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia marc1 35
  • 56.61 (n)
  • 49.82 (a)
zebrafish
(Danio rerio)
Actinopterygii MARC2 36
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1665 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F22B8.7 36
  • 29 (a)
ManyToMany
F53E10.1 36
  • 28 (a)
ManyToMany
F56A11.5 36
  • 30 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G44720 35
  • 46.12 (n)
  • 37.07 (a)
rice
(Oryza sativa)
Liliopsida Os09g0560800 35
  • 45.65 (n)
  • 33.58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
OneToMany
Species with no ortholog for MARC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARC2 Gene

ENSEMBL:
Gene Tree for MARC2 (if available)
TreeFam:
Gene Tree for MARC2 (if available)

Paralogs for MARC2 Gene

Paralogs for MARC2 Gene

(1) SIMAP similar genes for MARC2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MARC2 Gene

genes like me logo Genes that share paralogs with MARC2: view

Variants for MARC2 Gene

Sequence variations from dbSNP and Humsavar for MARC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3795535 - 220,763,030(-) ACAGC(C/T)GGTCA nc-transcript-variant, reference, missense
VAR_062275 -
rs76664695 - 220,763,035(+) GGCTG(G/T)GATGC nc-transcript-variant, reference, missense
rs234223 -- 220,745,890(-) gatca(C/G)gaggt upstream-variant-2KB
rs182872 -- 220,763,078(-) GAGCA(C/T)GATGC intron-variant

Variation tolerance for MARC2 Gene

Residual Variation Intolerance Score: 71.8% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MARC2 Gene

HapMap Linkage Disequilibrium report
MARC2
Human Gene Mutation Database (HGMD)
MARC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MARC2 Gene

Disorders for MARC2 Gene

Relevant External Links for MARC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MARC2

No disorders were found for MARC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MARC2 Gene

Publications for MARC2 Gene

  1. Functional characterization of protein variants encoded by non- synonymous SNPs in MARC1 and MARC2 in healthy Caucasians. (PMID: 24423752) Ott G. … Havemeyer A. (Drug Metab. Dispos. 2014) 3 4 67
  2. MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases. (PMID: 11886751) Anantharaman V. … Aravind L. (FEMS Microbiol. Lett. 2002) 2 3
  3. The mammalian molybdenum enzymes of mARC. (PMID: 25425164) Ott G. … Clement B. (J. Biol. Inorg. Chem. 2015) 3
  4. The pivotal role of the mitochondrial amidoxime reducing component 2 in protecting human cells against apoptotic effects of the base analog N6-hydroxylaminopurine. (PMID: 25713076) Plitzko B. … Clement B. (J. Biol. Chem. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for MARC2 Gene

Sources for MARC2 Gene

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