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Aliases for MARC1 Gene

Aliases for MARC1 Gene

  • Mitochondrial Amidoxime Reducing Component 1 2 3
  • Molybdenum Cofactor Sulfurase C-Terminal Domain-Containing Protein 1 3 4
  • Moco Sulfurase C-Terminal Domain-Containing Protein 1 3 4
  • MOCO Sulphurase C-Terminal Domain Containing 1 2 3
  • MOSC1 3 4
  • MOSC Domain-Containing Protein 1, Mitochondrial 3
  • MOSC Domain-Containing Protein 1 4
  • EC 1.-.-.- 4
  • MARC1 4

External Ids for MARC1 Gene

Previous HGNC Symbols for MARC1 Gene

  • MOSC1

Previous GeneCards Identifiers for MARC1 Gene

  • GC01P220961

Summaries for MARC1 Gene

GeneCards Summary for MARC1 Gene

MARC1 (Mitochondrial Amidoxime Reducing Component 1) is a Protein Coding gene. GO annotations related to this gene include pyridoxal phosphate binding and molybdenum ion binding. An important paralog of this gene is MOCOS.

UniProtKB/Swiss-Prot for MARC1 Gene

  • As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARC1 Gene

Genomics for MARC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MARC1 Gene

Chromosome:
1
Start:
220,786,697 bp from pter
End:
220,819,657 bp from pter
Size:
32,961 bases
Orientation:
Plus strand

Genomic View for MARC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARC1 Gene

No data available for Regulatory Elements for MARC1 Gene

Proteins for MARC1 Gene

  • Protein details for MARC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VT66-MARC1_HUMAN
    Recommended name:
    Mitochondrial amidoxime-reducing component 1
    Protein Accession:
    Q5VT66
    Secondary Accessions:
    • A8K447
    • B2D078
    • Q5VVS9
    • Q5VVT0
    • Q5VVT1
    • Q8N9P5
    • Q96FN8
    • Q9H6C7

    Protein attributes for MARC1 Gene

    Size:
    337 amino acids
    Molecular mass:
    37499 Da
    Cofactor:
    Name=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302; Note=Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.;
    Quaternary structure:
    • Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase and MARC1
    SequenceCaution:
    • Sequence=BAB15333.1; Type=Frameshift; Positions=139; Evidence={ECO:0000305}; Sequence=CAH72118.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MARC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MARC1 Gene

Proteomics data for MARC1 Gene at MOPED

Post-translational modifications for MARC1 Gene

  • Ubiquitination at Lys 310
  • Modification sites at PhosphoSitePlus

Other Protein References for MARC1 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MARC1

No data available for DME Specific Peptides for MARC1 Gene

Domains & Families for MARC1 Gene

Protein Domains for MARC1 Gene

Suggested Antigen Peptide Sequences for MARC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VT66

UniProtKB/Swiss-Prot:

MARC1_HUMAN :
  • Contains 1 MOSC domain.
Domain:
  • Contains 1 MOSC domain.
genes like me logo Genes that share domains with MARC1: view

No data available for Gene Families for MARC1 Gene

Function for MARC1 Gene

Molecular function for MARC1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=180 uM for benzamidoxime {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; KM=86 uM for NOHA {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; KM=272 uM for NHAM {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; Vmax=34 nmol/min/mg enzyme toward benzamidoxime {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; Vmax=105 nmol/min/mg enzyme toward benzamidoxime (PubMed:24423752, at pH 6.0 and 37 degrees Celsius) {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; Vmax=55 nmol/min/mg enzyme toward NOHA {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752}; Vmax=43 nmol/min/mg enzyme toward NHAM {ECO:0000269 PubMed:21029045, ECO:0000269 PubMed:24423752};
UniProtKB/Swiss-Prot Function:
As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively.

Enzyme Numbers (IUBMB) for MARC1 Gene

Gene Ontology (GO) - Molecular Function for MARC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0008940 nitrate reductase activity IDA 20861021
GO:0030151 molybdenum ion binding IDA 20861021
GO:0030170 pyridoxal phosphate binding IEA --
GO:0043546 molybdopterin cofactor binding IDA 20861021
genes like me logo Genes that share ontologies with MARC1: view

Phenotypes for MARC1 Gene

GenomeRNAi human phenotypes for MARC1:
genes like me logo Genes that share phenotypes with MARC1: view

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for MARC1 Gene

Localization for MARC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARC1 Gene

Mitochondrion outer membrane; Single-pass type II membrane protein. Note=Mitochondrial import is mediated by AA 1-40 and requires ATP.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MARC1 Gene COMPARTMENTS Subcellular localization image for MARC1 gene
Compartment Confidence
mitochondrion 4

Gene Ontology (GO) - Cellular Components for MARC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS 20861021
GO:0005741 mitochondrial outer membrane IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MARC1: view

Pathways & Interactions for MARC1 Gene

SuperPathways for MARC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MARC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0042126 nitrate metabolic process IDA 20861021
GO:0051410 detoxification of nitrogen compound NAS 20861021
GO:0055114 oxidation-reduction process IDA 20861021
genes like me logo Genes that share ontologies with MARC1: view

No data available for Pathways by source and SIGNOR curated interactions for MARC1 Gene

Drugs & Compounds for MARC1 Gene

(1) Drugs for MARC1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Molybdenum Pharma 24
genes like me logo Genes that share compounds with MARC1: view

Transcripts for MARC1 Gene

Unigene Clusters for MARC1 Gene

Mitochondrial amidoxime reducing component 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MARC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARC1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: - -
SP2: -
SP3: -
SP4: -

Relevant External Links for MARC1 Gene

GeneLoc Exon Structure for
MARC1
ECgene alternative splicing isoforms for
MARC1

Expression for MARC1 Gene

mRNA expression in normal human tissues for MARC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MARC1 Gene

This gene is overexpressed in Whole Blood (x8.1), Adipose - Visceral (Omentum) (x7.6), and Adipose - Subcutaneous (x6.3).

Protein differential expression in normal tissues from HIPED for MARC1 Gene

This gene is overexpressed in Testis (19.5), Nasopharynx (19.3), and Monocytes (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MARC1 Gene



SOURCE GeneReport for Unigene cluster for MARC1 Gene Hs.497816

genes like me logo Genes that share expression patterns with MARC1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MARC1 Gene

Orthologs for MARC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MARC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MARC1 35
  • 86.21 (n)
  • 86.61 (a)
MARC1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MARC1 35
  • 86.45 (n)
  • 88.62 (a)
MARC1 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Marc1 35
  • 79.34 (n)
  • 79.04 (a)
Marc1 16
Marc1 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MOSC1 35
  • 99.31 (n)
  • 99.11 (a)
MARC1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Marc1 35
  • 80.17 (n)
  • 77.53 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia MARC1 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves MARC2 35
  • 67.59 (n)
  • 63.08 (a)
-- 36
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 6 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487963 35
  • 58.88 (n)
  • 56.07 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25253 35
zebrafish
(Danio rerio)
Actinopterygii zgc:110783 35
  • 58.36 (n)
  • 50.9 (a)
MARC2 36
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1665 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F56A11.5 35
  • 48.63 (n)
  • 37.99 (a)
F22B8.7 36
  • 29 (a)
ManyToMany
F53E10.1 36
  • 29 (a)
ManyToMany
F56A11.5 36
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
OneToMany
Species with no ortholog for MARC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARC1 Gene

ENSEMBL:
Gene Tree for MARC1 (if available)
TreeFam:
Gene Tree for MARC1 (if available)

Paralogs for MARC1 Gene

Paralogs for MARC1 Gene

(1) SIMAP similar genes for MARC1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MARC1: view

Variants for MARC1 Gene

Sequence variations from dbSNP and Humsavar for MARC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs746767 -- 220,785,617(+) GGGAT(A/G)ACACA upstream-variant-2KB
rs867772 -- 220,799,001(+) TCTGC(A/G)CTGGC intron-variant, utr-variant-3-prime, nc-transcript-variant
rs868494 -- 220,786,175(-) CCTCA(A/G)TCACT upstream-variant-2KB
rs881995 -- 220,811,152(+) ACCCT(C/T)TGACA intron-variant
rs883847 -- 220,798,986(+) CGGCT(C/G)GTTTC intron-variant, utr-variant-3-prime, nc-transcript-variant

Variation tolerance for MARC1 Gene

Residual Variation Intolerance Score: 91.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MARC1 Gene

HapMap Linkage Disequilibrium report
MARC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MARC1 Gene

Disorders for MARC1 Gene

Relevant External Links for MARC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MARC1
genes like me logo Genes that share disorders with MARC1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MARC1 Gene

Publications for MARC1 Gene

  1. MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases. (PMID: 11886751) Anantharaman V. … Aravind L. (FEMS Microbiol. Lett. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Functional characterization of protein variants encoded by non- synonymous SNPs in MARC1 and MARC2 in healthy Caucasians. (PMID: 24423752) Ott G. … Havemeyer A. (Drug Metab. Dispos. 2014) 67
  4. Nitrite reductase and nitric-oxide synthase activity of the mitochondrial molybdopterin enzymes mARC1 and mARC2. (PMID: 24500710) Sparacino-Watkins C.E. … Gladwin M.T. (J. Biol. Chem. 2014) 67
  5. The involvement of mitochondrial amidoxime reducing components 1 and 2 and mitochondrial cytochrome b5 in N-reductive metabolism in human cells. (PMID: 23703616) Plitzko B. … Havemeyer A. (J. Biol. Chem. 2013) 67

Products for MARC1 Gene

Sources for MARC1 Gene

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