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MAPT Gene

protein-coding   GIFtS: 73
GCID: GC17P043971

Microtubule-Associated Protein Tau


(Previous symbols: DDPAC, MAPTL)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microtubule-Associated Protein Tau1 2     PHF-tau2 3
MAPTL1 2 3     TAU2 3
DDPAC1 2 5     MSTD2 5
MTBT12 3 5     Isoform 41
G Protein Beta1/Gamma2 Subunit-Interacting Factor 11 2     FTDP-172
Neurofibrillary Tangle Protein2 3     MTBT22
Paired Helical Filament-Tau2 3     PPND2

External Ids:    HGNC: 68931   Entrez Gene: 41372   Ensembl: ENSG000001868687   OMIM: 1571405   UniProtKB: P106363   

Export aliases for MAPT gene to outside databases

Previous GC identifers: GC17P043566 GC17P046217 GC17P043982 GC17P044447 GC17P041327 GC17P039635


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPT Gene:
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated
alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the
nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been
associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal
dementia, cortico-basal degeneration and progressive supranuclear palsy. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAPT Gene:
MAPT (microtubule-associated protein tau) is a protein-coding gene. Diseases associated with MAPT include parkinson's disease, and pick's disease. GO annotations related to this gene include microtubule binding and protein kinase binding. An important paralog of this gene is MAP4.

UniProtKB/Swiss-Prot: TAU_HUMAN, P10636
Function: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance
of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane
components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by
TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short
isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its
stabilization

Gene Wiki entry for MAPT (Tau protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NT_187663.1  NT_167251.2  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPT gene promoter:
         CREB   ATF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAPT promoter sequence
   Search Chromatin IP Primers for MAPT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.1   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21

MAPT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPT gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P043971:  view genomic region     (about GC identifiers)

Start:
43,971,748 bp from pter      End:
44,105,700 bp from pter
Size:
133,953 bases      Orientation:
plus strand

2 alternative locations:
Chr17-,NT_167251 766,170-827,995      Chr17-,ALT_REF_LOCI_9 44,150,125-44,280,402     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TAU_HUMAN, P10636 (See protein sequence)
Recommended Name: Microtubule-associated protein tau  
Size: 758 amino acids; 78928 Da
Subunit: Interacts with PSMC2 through SQSTM1 (By similarity). Interacts with SQSTM1 when polyubiquitinated.
Interacts with FKBP4 (By similarity). Binds to CSNK1D. Interacts with SGK1
Developmental stage: Four-repeat (type II) TAU/MAPT is expressed in an adult-specific manner and is not found in
fetal brain, whereas three-repeat (type I) TAU/MAPT is found in both adult and fetal brain
5 PDB 3D structures from and Proteopedia for MAPT:
1I8H (3D)        3OVL (3D)        4FL5 (3D)        4GLR (3D)        4NP8 (3D)    
Secondary accessions: P18518 Q14799 Q15549 Q15550 Q15551 Q1RMF6 Q53YB1 Q5CZI7 Q5XWF0 Q6QT54
Q9UDJ3 Q9UMH0 Q9UQ96
Alternative splicing: 9 isoforms:  P10636-1   P10636-2   P10636-3   P10636-4   P10636-5   P10636-6   P10636-7   P10636-8   
P10636-9   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAPT: NX_P10636

Explore proteomics data for MAPT at MOPED

Post-translational modifications: 

  • Phosphorylation at serine and threonine residues in S-P or T-P motifs by proline-directed protein kinases (PDPK1:
    CDK1, CDK5, GSK3, MAPK) (only 2-3 sites per protein in interphase, seven-fold increase in mitosis, and in the
    form associated with paired helical filaments (PHF-tau)), and at serine residues in K-X-G-S motifs by
    MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their
    disassembly. Phosphorylation decreases with age. Phosphorylation within tau/MAP's repeat domain or in flanking
    regions seems to reduce tau/MAP's interaction with, respectively, microtubules or plasma membrane components.
    Phosphorylation on Ser-610, Ser-622, Ser-641 and Ser-673 in several isoforms during mitosis. Phosphorylation at
    Ser-548 by GSK3B reduces ability to bind and stabilize microtubules. Phosphorylation at Ser-579 by BRSK1 and
    BRSK2 in neurons affects ability to bind microtubules and plays a role in neuron polarization. Phosphorylated at
    Ser-554, Ser-579, Ser-602, Ser-606 and Ser-669 by PHK. Phosphorylation at Ser-214 by SGK1 mediates microtubule
    depolymerization and neurite formation in hippocampal neurons. There is a reciprocal down-regulation of
    phosphorylation and O-GlcNAcylation. Phosphorylation on Ser-717 completely abolishes the O-GlcNAcylation on this
    site, while phosphorylation on Ser-713 and Ser-721 reduces glycosylation by a factor of 2 and 4 respectively.
    Phosphorylation on Ser-721 is reduced by about 41.5% by GlcNAcylation on Ser-717. Dephosphorylated at several
    serine and threonine residues by the serine/threonine phosphatase PPP5C1
  • Polyubiquitinated. Requires functional TRAF6 and may provoke SQSTM1-dependent degradation by the proteasome (By
    similarity). PHF-tau can be modified by three different forms of polyubiquitination. 'Lys-48'-linked
    polyubiquitination is the major form, 'Lys-6'-linked and 'Lys-11'-linked polyubiquitination also occur1
  • O-glycosylated. O-GlcNAcylation content is around 8.2%. There is reciprocal down-regulation of phosphorylation and
    O-GlcNAcylation. Phosphorylation on Ser-717 completely abolishes the O-GlcNAcylation on this site, while
    phosphorylation on Ser-713 and Ser-721 reduces O-GlcNAcylation by a factor of 2 and 4 respectively.
    O-GlcNAcylation on Ser-717 decreases the phosphorylation on Ser-721 by about 41.5%1
  • Glycation of PHF-tau, but not normal brain TAU/MAPT. Glycation is a non-enzymatic post-translational modification
    that involves a covalent linkage between a sugar and an amino group of a protein molecule forming ketoamine.
    Subsequent oxidation, fragmentation and/or cross-linking of ketoamine leads to the production of advanced
    glycation endproducts (AGES). Glycation may play a role in stabilizing PHF aggregation leading to tangle
    formation in AD1
  • Glycosylation2 at Lys87, Lys383, Lys467, Lys480, Lys491, Ser525, Lys542, Lys551, Ser555, Lys576,
                                 Lys597, Lys598, Lys664, Lys670, Lys686, Ser717
  • Modification sites at PhosphoSitePlus

  • See MAPT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001116538.2  NP_001116539.1  NP_001190180.1  NP_001190181.1  NP_005901.2  NP_058518.1  NP_058519.3  NP_058525.1  

    ENSEMBL proteins: 
     ENSP00000460048   ENSP00000334886   ENSP00000408975   ENSP00000413056   ENSP00000410838  
     ENSP00000458742   ENSP00000460965   ENSP00000389250   ENSP00000458621   ENSP00000340820  
     ENSP00000262410   ENSP00000303214   ENSP00000340438   ENSP00000443028   ENSP00000302706  
    Reactome Protein details: P10636

    MAPT Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MAPT Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for MAPT
    OriGene Purified Proteins for MAPT
    OriGene Protein Over-expression Lysate for MAPT
    OriGene MassSpec for MAPT
    OriGene Custom Protein Services for MAPT
    GenScript Custom Purified and Recombinant Proteins Services for MAPT
    Novus Biologicals MAPT Proteins
    Novus Biologicals MAPT Lysates
    Sino Biological Recombinant Protein for MAPT
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MAPT
    Browse Proteins at Cloud-Clone Corp.

    MAPT Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPT
    R&D Systems Antibodies for MAPT (Tau)
    Cell Signaling Technology (CST) Antibodies for MAPT  (tau iso8)
    OriGene Antibodies for MAPT
    OriGene Custom Antibody Services for MAPT
    Novus Biologicals MAPT Antibodies
    Abcam antibodies for MAPT
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for MAPT
    LSBio Antibodies in human, mouse, rat for MAPT

    MAPT Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAPT
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAPT
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR027324 MAP2/MAP4/Tau
     IPR002955 Tau
     IPR001084 MAP_tubulin-bd_rpt

    Graphical View of Domain Structure for InterPro Entry P10636

    ProtoNet protein and cluster: P10636

    2 Blocks protein domains:
    IPB001084 Tubulin-binding Tau protein
    IPB002955 Tau protein signature


    UniProtKB/Swiss-Prot: TAU_HUMAN, P10636
    Domain: The tau/MAP repeat binds to tubulin. Type I isoforms contain 3 repeats while type II isoforms contain 4
    repeats
    Similarity: Contains 4 Tau/MAP repeats


    MAPT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAU_HUMAN, P10636
    Function: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance
    of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane
    components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by
    TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short
    isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its
    stabilization

         Genatlas biochemistry entry for MAPT:
    microtubule (beta) associated protein tau 1,primary component of paired helical filaments with six alternatively
    spliced forms in normal adult brain,regulating the transport of vesicles or organelles along
    microtubules,phosphorylated by CDK5 and other kinases with decrease of affinity for microtubules,forming tangles
    of paired helical filaments (PHF) consisting of hyperphosphorylated tau protein observed in Alzheimer disease
    (triplet PHF-tau),overexpressed in extraskeletal myxoid chondrosarcoma and chordoma

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005200structural constituent of cytoskeleton TAS2498079
    GO:0005515protein binding IPI10987820
    GO:0008017microtubule binding IDA1918161
    GO:0015631tubulin binding ----
    GO:0017124SH3 domain binding IPI9763511
         
    MAPT for ontologies           About GeneDecksing


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 20 alleles(MGI details for Mapt) (see all 16):
     behavior/neurological  cellular  growth/size/body  hematopoietic system  immune system 
     integument  mortality/aging  muscle  nervous system  no phenotypic analysis 
     normal  other  renal/urinary system  taste/olfaction  tumorigenesis 

    MAPT for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MAPT: Mapttm1Aha Mapttm1Noh Mapttm1Hnd

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAPT
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAPT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPT

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAPT:
    hsa-mir-34c-5p (MIRT007189)

    Block miRNA regulation of human, mouse, rat MAPT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPT (see all 62):
    hsa-miR-579 hsa-miR-582-3p hsa-miR-513a-5p hsa-miR-146a hsa-miR-3616-5p hsa-miR-219-5p hsa-miR-759 hsa-miR-766
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAPT
    Predesigned siRNA for gene silencing in human, mouse, rat MAPT

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAPT

    Clone
    Products:
         
    OriGene clones in human, mouse for MAPT (see all 37)
    OriGene ORF clones in mouse, rat for MAPT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): MAPT (NM_001203251)
    Sino Biological Human cDNA Clone for MAPT
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPT

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAPT
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAPT 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TAU_HUMAN, P10636: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm,
    cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association
    with plasma membrane components
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    nucleus5
    plasma membrane5
    vacuole3
    endoplasmic reticulum2
    extracellular2
    lysosome2
    mitochondrion2
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005874microtubule IEA--
    GO:0005875microtubule associated complex TAS10747907

    MAPT for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPT About   (see all 22)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3Alzheimer's disease
    Alzheimers Disease0.44
    Alzheimer's disease0.44
    4Apoptotic cleavage of cellular proteins
    Apoptotic cleavage of cellular proteins0.74
    Caspase-mediated cleavage of cytoskeletal proteins0.00
    Apoptotic execution phase0.74
    5Apoptotic Pathways in Synovial Fibroblasts
    DHA Signaling0.74

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAPT
        DHA Signaling
    Reelin Pathway (Cajal-Retzius cells)
    Alzheimers Disease Pathway
    CDK5 Pathway
    14-3-3 Induced Intracellular Signaling

    2 Cell Signaling Technology (CST) Pathways for MAPT
        Neuroscience
    Cytoskeletal Signaling

    3 GeneGo (Thomson Reuters) Pathways for MAPT
        Neurophysiological process Receptor-mediated axon growth repulsion
    Development Slit-Robo signaling
    Cytoskeleton remodeling Reverse signaling by ephrin B

    Selected BioSystems Pathways for MAPT (see all 9)
        MAPK signaling pathway
    BDNF signaling pathway
    IL-6 Signaling Pathway
    IL-2 Signaling pathway
    Integrated Pancreatic Cancer Pathway


    1 Reactome Pathway for MAPT
        Caspase-mediated cleavage of cytoskeletal proteins

    1 PharmGKB Pathway for MAPT
        Taxane Pathway, Pharmacokinetics

    2 Kegg Pathways  (Kegg details for MAPT):
        MAPK signaling pathway
    Alzheimer's disease


    MAPT for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPT: 
              Parkinson's Disease in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Alzheimer's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAPT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPT (P106361, 2, 3 ENSP000003408204) via UniProtKB, MINT, STRING, and/or I2D (see all 120)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498411, 2, 3, ENSP000003248064EBI-366233,EBI-373586 MINT-3974171 MINT-8211409 MINT-8211397 MINT-8211467 MINT-8210275 MINT-3974216 MINT-8211419 I2D: score=4 STRING: ENSP00000324806
    DCTN1Q142031, 2, ENSP000003547914EBI-366233,EBI-724352 MINT-6174402 MINT-6174455 MINT-6174443 MINT-6174393 MINT-6174470 MINT-6174367 MINT-6174383 MINT-6174419 STRING: ENSP00000354791
    YWHAZP631041, 2, 3, ENSP000003095034EBI-7145070,EBI-347088 MINT-8009131 MINT-7233346 MINT-7233334 MINT-7233310 MINT-8009145 MINT-7233285 MINT-8009138 MINT-8008750 MINT-7233372 MINT-7233358 MINT-7233384 MINT-7233323 MINT-7233297 I2D: score=4 STRING: ENSP00000309503
    AATFQ9NY612, 3, ENSP000002254024MINT-49642 MINT-49641 I2D: score=4 STRING: ENSP00000225402
    RPS6KB1P234432, 3, ENSP000002255774MINT-74872 MINT-74874 I2D: score=1 STRING: ENSP00000225577
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IDA1057175
    GO:0001764neuron migration IEA--
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0007409axonogenesis ----

    MAPT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAPT (TAU)

    2 DrugBank Compounds for MAPT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DocetaxelDocetaxel anhydrous (see all 4)114977-28-5target--18068131
    Paclitaxel7-epi-Paclitaxel (see all 8)33069-62-4target--18068131

    Selected Novoseek inferred chemical compound relationships for MAPT gene (see all 103)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 75.5 236 8809831 (5), 15075227 (4), 16951581 (3), 9666118 (3) (see all 99)
    ammonium polyphosphate 65.8 7 8797796 (3), 16877359 (1), 9839715 (1)
    thioflavine s 64.9 10 1759562 (2), 10446806 (1), 15814784 (1), 20448485 (1) (see all 7)
    okadaic acid 61.2 87 8494335 (4), 7723735 (4), 8414191 (3), 7693894 (3) (see all 39)
    thioflavin 60.7 6 19266322 (2), 17082178 (1), 14975751 (1)
    map4 59.4 9 15642108 (2), 1905296 (1), 7854050 (1), 9144194 (1) (see all 8)
    threonine 49.9 32 15913839 (2), 17362433 (1), 9736660 (1), 11078890 (1) (see all 22)
    silver 47.4 29 9708963 (2), 10768809 (2), 7692696 (1), 7521944 (1) (see all 21)
    serine 44.9 49 8486651 (3), 9079670 (2), 9199504 (2), 15913839 (2) (see all 33)
    maltolate 39.4 1 9401741 (1)



    MAPT for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAPT gene (8 alternative transcripts): 
    NM_001123066.3  NM_001123067.3  NM_001203251.1  NM_001203252.1  NM_005910.5  NM_016834.4  NM_016835.4  NM_016841.4  

    Unigene Cluster for MAPT:

    Microtubule-associated protein tau
    Hs.101174  [show with all ESTs]
    Unigene Representative Sequence: NM_001123066
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000571311 ENST00000570299 ENST00000334239 ENST00000446361 ENST00000420682
    ENST00000415613 ENST00000571987 ENST00000574436 ENST00000431008 ENST00000576518
    ENST00000572440 ENST00000576238(uc021tyx.1) ENST00000577017 ENST00000344290(uc010dau.3)
    ENST00000262410(uc002ijr.4) ENST00000351559(uc002ijs.4) ENST00000340799(uc002ijx.4 uc002ijt.4)
    ENST00000535772(uc021tyv.1 uc021tyw.1 uc002iju.4)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MAPT (see all 62):
    hsa-miR-579 hsa-miR-582-3p hsa-miR-513a-5p hsa-miR-146a hsa-miR-3616-5p hsa-miR-219-5p hsa-miR-759 hsa-miR-766
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    Predesigned siRNA for gene silencing in human, mouse, rat MAPT
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    OriGene ORF clones in mouse, rat for MAPT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): MAPT (NM_001203251)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPT
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      QuantiTect SYBR Green Assays in human, mouse, rat MAPT
      QuantiFast Probe-based Assays in human, mouse, rat MAPT

    Additional mRNA sequence: 

    AB073354.1 AF456477.1 AK055986.1 AK095802.1 AK299658.1 AK299704.1 AY526356.1 AY730549.1 
    BC000558.2 BC032572.1 BC040444.1 BC061892.1 BC071830.1 BC094805.1 BC098281.1 BC099721.1 
    BC101936.1 BC114504.1 BC114948.1 BT006772.1 J03778.1 X14474.1 

    20 DOTS entries:

    DT.100836823  DT.415460  DT.97813963  DT.100836827  DT.100000370  DT.100836820  DT.91775673  DT.100836816 
    DT.100836818  DT.75182379  DT.91775685  DT.100836817  DT.100836831  DT.95166690  DT.95166953  DT.95166983 
    DT.95193501  DT.75102946  DT.91775667  DT.95176899 

    Selected AceView cDNA sequences (see all 343):

    BM547659 BG911100 BX425932 F07752 AA223656 BX420493 AI365507 BG056860 
    BM714407 X14474 BC032572 BM722070 AW157488 BQ068264 AA323128 BC000558 
    AI363314 BX097824 BE221835 T16312 BG056178 AW250075 F03259 AK055986 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAPT (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b
    SP1:                                      -                                                                                 
    SP2:                          -           -     -     -           -           -                                             
    SP3:                    -     -           -     -     -           -           -                                             
    SP4:                    -     -           -     -     -           -           -           -                                 
    SP5:                          -     -     -     -     -           -           -           -                                 


    ECgene alternative splicing isoforms for MAPT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAPT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATCATCTT
    MAPT Expression
    About this image


    MAPT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 6 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Endothelial Cells Blood Brain Barrier
             Pons
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
    MAPT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.101174

    UniProtKB/Swiss-Prot: TAU_HUMAN, P10636
    Tissue specificity: Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the
    others are expressed in the central nervous system

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPT: 
              Parkinson's Disease in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Alzheimer's Disease in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MAPT gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapt1 , 5 microtubule-associated protein tau1, 5 84.92(n)1
    90(a)1
      11 (67.79 cM)5
    177621  NM_001038609.21  NP_001033698.11 
     1042313905 
    chicken
    (Gallus gallus)
    Aves MAPT1 microtubule-associated protein tau 78.37(n)
    83.97(a)
      426737  NM_001199193.1  NP_001186122.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAPT6
    microtubule-associated protein tau
    72(a)
    1 ↔ 1
    6(66953395-67038336)
    African clawed frog
    (Xenopus laevis)
    Amphibia AY032848.12   -- 77.54(n)    AY032848.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI981282.12   -- 74.26(n)    BI981282.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tau6
    tau
    27(a)
    1 → many
    3R(23466365-23482718)
    worm
    (Caenorhabditis elegans)
    Secernentea ptl-16
    Protein PTL-1, isoform b
    16(a)
    1 → many
    III(763810-771390) WBGene00004212


    ENSEMBL Gene Tree for MAPT (if available)
    TreeFam Gene Tree for MAPT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAPT gene
    MAP42  MAP22  
    3 SIMAP similar genes for MAPT using alignment to 4 protein entries:     TAU_HUMAN (see all proteins):
    4R-MAP2    DKFZp547H1810    MAP4

    MAPT for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAPT (see all 3163)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs637509591,2,,4
    C,FProgressive supranuclear palsy 1 (PSNP1)4 pathogenic145236737(+) GCCCCA/G/TCCAGG 24 H R L mis11EA 212
    VAR_0103444
    Pick disease of the brain (PIDB)4--see VAR_0103442 K T mis40--------
    VAR_0374404
    Frontotemporal dementia (FTD)4--see VAR_0374402 K M mis40--------
    VAR_0196664
    Frontotemporal dementia (FTD)4--see VAR_0196662 E V mis40--------
    VAR_0103514
    Frontotemporal dementia (FTD)4--see VAR_0103512 V M mis40--------
    VAR_0103464
    Frontotemporal dementia (FTD)4--see VAR_0103462 N K mis40--------
    VAR_0196654
    Pick disease of the brain (PIDB)4--see VAR_0196652 S F mis40--------
    VAR_0103494
    Frontotemporal dementia (FTD)4--see VAR_0103492 P S mis40--------
    VAR_0196624
    Frontotemporal dementia (FTD)4--see VAR_0196622 L V mis40--------
    VAR_0103504
    Frontotemporal dementia (FTD)4--see VAR_0103502 S N mis40--------

    HapMap Linkage Disequilibrium report for MAPT (43971748 - 44105700 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAPT (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715976CNV Deletion23290073
    esv2676042CNV Deletion23128226
    nsv2068CNV Insertion18451855
    nsv469705CNV Loss16826518
    nsv510714CNV Loss20534489
    esv6819CNV Gain19470904
    dgv128e55CNV Gain17911159
    dgv127e55CNV Gain17911159
    esv2751686CNV Gain17911159
    nsv471698CNV Gain+Loss15918152

    Human Gene Mutation Database (HGMD): MAPT
    Locus Specific Mutation Databases (LSDB): MAPT

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAPT
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 157140   
    OMIM disorders: 600274  172700  601104  260540  168600  
    UniProtKB/Swiss-Prot: TAU_HUMAN, P10636
  • Note=In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced
    by tangles of paired helical filaments (PHF) and straight filaments, mainly composed of hyperphosphorylated forms
    of TAU (PHF-TAU or AD P-TAU). O-GlcNAcylation is greatly reduced in Alzheimer disease brain cerebral cortex
    leading to an increase in TAU/MAPT phosphorylations
  • Frontotemporal dementia (FTD) [MIM:600274]: A form of dementia characterized by pathologic finding of
    frontotemporal lobar degeneration, presenile dementia with behavioral changes, deterioration of cognitive
    capacities and loss of memory. In some cases, parkinsonian symptoms are prominent. Neuropathological changes
    include frontotemporal atrophy often associated with atrophy of the basal ganglia, substantia nigra, amygdala. In
    most cases, protein tau deposits are found in glial cells and/or neurons. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Pick disease of the brain (PIDB) [MIM:172700]: A rare form of dementia pathologically defined by severe
    atrophy, neuronal loss and gliosis. It is characterized by the occurrence of tau-positive inclusions, swollen
    neurons (Pick cells) and argentophilic neuronal inclusions known as Pick bodies that disproportionally affect the
    frontal and temporal cortical regions. Clinical features include aphasia, apraxia, confusion, anomia, memory loss
    and personality deterioration. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • Note=Defects in MAPT are a cause of corticobasal degeneration (CBD). It is marked by extrapyramidal signs
    and apraxia and can be associated with memory loss. Neuropathologic features may overlap Alzheimer disease,
    progressive supranuclear palsy, and Parkinson disease
  • Progressive supranuclear palsy 1 (PSNP1) [MIM:601104]: Characterized by akinetic-rigid syndrome,
    supranuclear gaze palsy, pyramidal tract dysfunction, pseudobulbar signs and cognitive capacities deterioration.
    Neurofibrillary tangles and gliosis but no amyloid plaques are found in diseased brains. Most cases appear to be
    sporadic, with a significant association with a common haplotype including the MAPT gene and the flanking
    regions. Familial cases show an autosomal dominant pattern of transmission with incomplete penetrance; genetic
    analysis of a few cases showed the occurrence of tau mutations, including a deletion of Asn-613. Note=The disease
    is caused by mutations affecting the gene represented in this entry
  • Parkinson-dementia syndrome (PARDE) [MIM:260540]: A syndrome characterized by parkinsonism, tremor,
    rigidity, dementia, ophthalmoparesis and pyramidal signs. Neurofibrillary degeneration occurs in the hippocampus,
    basal ganglia and brainstem nuclei. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • Selected diseases for MAPT (see all 126):    
    About MalaCards
    parkinson's disease    pick's disease    progressive non-fluent aphasia    progressive supranuclear palsy atypical
    progressive supranuclear palsy - progressive non fluent aphasia    corticobasal degeneration    progressive supranuclear palsy - pure akinesia with gait freezing    posterior cortical atrophy
    progressive supranuclear palsy    progressive supranuclear palsy - corticobasal syndrome    tauopathy    frontotemporal dementia with parkinsonism-17
    mapt-related disorders    dementia, frontotemporal, with or without parkinsonism    tauopathy and respiratory failure    dementia
    spinocerebellar ataxia type 11    semantic dementia    frontotemporal dementia, ubiquitin-positive    frontotemporal dementia

    11 diseases from the University of Copenhagen DISEASES database for MAPT:
    Frontotemporal dementia     Alzheimer's disease     Progressive supranuclear palsy     Pick's disease
    Aphasia     Parkinson's disease     Lewy body dementia     Pelvic inflammatory disease
    Toxic encephalopathy     Amyotrophic lateral sclerosis     Apraxia

    MAPT for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for MAPT gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tauopathies 97.7 677 11810404 (5), 15814784 (5), 18346207 (5), 12435607 (5) (see all 99)
    paired helical filament 97.6 517 18783251 (3), 1639844 (3), 9062894 (3), 7694533 (3) (see all 99)
    neurofibrillary tangles 97.1 610 11932941 (4), 15056457 (3), 9686275 (3), 11786218 (3) (see all 99)
    frontotemporal dementia 96 581 18591058 (4), 15376481 (4), 11585254 (3), 10436346 (3) (see all 99)
    alzheimers disease 94.8 1534 17168644 (5), 7838376 (5), 7830071 (5), 8506352 (4) (see all 99)
    supranuclear palsy progressive 93.7 219 10209184 (4), 12151839 (3), 10534245 (3), 9781517 (2) (see all 99)
    picks disease 92 143 8960316 (5), 8928611 (4), 12368187 (4), 11117542 (3) (see all 76)
    neuropil threads 90.5 48 1904481 (2), 16106214 (2), 8396836 (1), 7521944 (1) (see all 34)
    senile plaques 89.8 149 15977985 (3), 15658002 (3), 1652752 (2), 7680597 (1) (see all 99)
    neurodegenerative diseases 89.8 450 11578782 (4), 10320789 (4), 15056452 (4), 15495240 (3) (see all 99)

    GeneTests: MAPT
    GeneReviews: MAPT
    Genetic Association Database (GAD): MAPT
    Human Genome Epidemiology (HuGE) Navigator: MAPT (139 documents)

    Export disorders for MAPT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPT gene, integrated from 10 sources (see all 2480):
    (articles sorted by number of sources associating them with MAPT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Familial atypical progressive supranuclear palsy associated with homozygosity for the delN296 mutation in the tau gene. (PubMed id 11220749)1, 2, 4, 9 Pastor P.... Oliva R. (Ann. Neurol. 2001)
    2. Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17. (PubMed id 9641683)1, 2, 4, 9 Hutton M.... Heutink P. (Nature 1998)
    3. Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. (PubMed id 3131773)1, 2, 3 Goedert M.... Klug A. (Proc. Natl. Acad. Sci. U.S.A. 1988)
    4. The role of tau (MAPT) in frontotemporal dementia and related tauopathies. (PubMed id 15365985)1, 2, 9 Rademakers R.... van Broeckhoven C. (Hum. Mutat. 2004)
    5. A polymorphism within intron 11 of the tau gene is not increased in frequency in patients with sporadic Alzheimer's disease, nor does it influence the extent of tau pathology in the brain. (PubMed id 11988340)1, 4, 9 Green E.K....Mann D.M. (Neurosci. Lett. 2002)
    6. Lack of association of APOE and tau polymorphisms with dementia in Parkinson's disease. (PubMed id 18930114)1, 4, 9 Ezquerra M....Tolosa E. (Neurosci. Lett. 2008)
    7. Effect of MAPT and APOE on prognosis of progressive supranuclear palsy. (PubMed id 16839689)1, 4, 9 Baba Y....Dickson D.W. (Neurosci. Lett. 2006)
    8. Frequency of tau gene mutations in familial and sporadic cases of non-Alzheimer dementia. (PubMed id 11255441)1, 4, 9 Poorkaj P....Bird T.D. (Arch. Neurol. 2001)
    9. Pick's disease is associated with mutations in the tau gene. (PubMed id 11117542)1, 2, 9 Pickering-Brown S.... Hutton M. (Ann. Neurol. 2000)
    10. Mutational analysis of the tau gene in progressive supranuclear palsy. (PubMed id 10534245)1, 2, 9 Higgins J.J.... Loveless J.M. (Neurology 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4137 HGNC: 6893 AceView: MAPT Ensembl:ENSG00000186868 euGenes: HUgn4137
    ECgene: MAPT Kegg: 4137 H-InvDB: MAPT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAPT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPT Genetics and Cytogenetics in Oncology and Haematology
    Alzheimer Research Forumhttp://www.alzforum.org/res/com/mut/tau/default.asp
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/068
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=MAPT[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/Tau_protein

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAPT gene:
    Search GeneIP for patents involving MAPT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     MAPT lysates
     Antibodies for MAPT
     See all of Abcam's Antibodies, Kits and Proteins for MAPT
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     Abcam protocols and scientific support
     Recombinant Protein for MAPT
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for MAPT
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPT
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MAPT
     SwitchGear Promoter luciferase reporter plasmids for MAPT
     ThermoFisher Antibody for MAPT
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPT
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAPT
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAPT
     LSBio Antibodies in human, mouse, rat for MAPT
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
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     Tissue-specific gene expresssion
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     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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