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MAPRE3 Gene

protein-coding   GIFtS: 60
GCID: GC02P027193

Microtubule-Associated Protein, RP/EB Family, Member 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microtubule-Associated Protein, RP/EB Family, Member 31 2     EB1 Protein Family Member 32 3
EB32 3 5     EBF3-S2
EBF32 3 5     APC Binding Protein2
RP32 3 5     Microtubule-Associated Protein RP/EB Family Member 32
End-Binding Protein 32 3     

External Ids:    HGNC: 68921   Entrez Gene: 229242   Ensembl: ENSG000000847647   OMIM: 6057885   UniProtKB: Q9UPY83   

Export aliases for MAPRE3 gene to outside databases

Previous GC identifers: GC02P027114 GC02P027286 GC02P027168 GC02P027105 GC02P026935


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPRE3 Gene:
The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the
cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAPRE3 Gene:
MAPRE3 (microtubule-associated protein, RP/EB family, member 3) is a protein-coding gene. Diseases associated with MAPRE3 include burkitt's lymphoma, and herpes simplex. GO annotations related to this gene include microtubule binding and small GTPase regulator activity. An important paralog of this gene is MAPRE2.

UniProtKB/Swiss-Prot: MARE3_HUMAN, Q9UPY8
Function: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton.
Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them
at centrosomes. May play a role in cell migration (By similarity)

Gene Wiki entry for MAPRE3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPRE3 gene promoter:
         MEF-2A   Sox5   Pax-5   AML1a   FOXO1a   aMEF-2   NF-kappaB1   Ik-3   LCR-F1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAPRE3 promoter sequence
   Search Chromatin IP Primers for MAPRE3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPRE3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3-p23.1   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3-p23.1

MAPRE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPRE3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P027193:  view genomic region     (about GC identifiers)

Start:
27,193,480 bp from pter      End:
27,250,087 bp from pter
Size:
56,608 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MARE3_HUMAN, Q9UPY8 (See protein sequence)
Recommended Name: Microtubule-associated protein RP/EB family member 3  
Size: 281 amino acids; 31982 Da
Subunit: Interacts with APC2 (By similarity). Homodimer. Heterodimer with MAPRE1. Interacts with DCTN1 and SRCIN1.
Binds to the C-terminal domain of APC. Binds monomeric and polymerized tubulin. Interacts (via C-terminus) with
CLIP1. Interacts with SLAIN2
Sequence caution: Sequence=AAK07556.1; Type=Erroneous initiation; Sequence=AAK07557.1; Type=Erroneous initiation;
Sequence=CAA72060.1; Type=Frameshift; Positions=199;
3 PDB 3D structures from and Proteopedia for MAPRE3:
1WYO (3D)        3CO1 (3D)        3TQ7 (3D)    
Secondary accessions: B7WPK5 O00265 Q6FHB0 Q6FI15 Q9BZP7 Q9BZP8
Alternative splicing: 2 isoforms:  Q9UPY8-1   Q9UPY8-2   

Explore the universe of human proteins at neXtProt for MAPRE3: NX_Q9UPY8

Explore proteomics data for MAPRE3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys113, Lys229
  • Modification sites at PhosphoSitePlus

  • See MAPRE3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036458.2  
    ENSEMBL proteins: 
     ENSP00000233121   ENSP00000383915   ENSP00000391705   ENSP00000385715  

    MAPRE3 Human Recombinant Protein Products:

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    MAPRE3 Antibody Products:

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    MAPRE3 Assay Products:

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    Cloud-Clone Corp. CLIAs for MAPRE3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001715 CH-domain
     IPR027328 MAPRE
     IPR027738 EB3
     IPR004953 EB1_C

    Graphical View of Domain Structure for InterPro Entry Q9UPY8

    ProtoNet protein and cluster: Q9UPY8

    2 Blocks protein domains:
    IPB001715 Calponin-like actin-binding
    IPB004953 EB1 protein


    UniProtKB/Swiss-Prot: MARE3_HUMAN, Q9UPY8
    Domain: Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved
    in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC
    and DCTN1
    Similarity: Belongs to the MAPRE family
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 EB1 C-terminal domain


    MAPRE3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARE3_HUMAN, Q9UPY8
    Function: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton.
    Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them
    at centrosomes. May play a role in cell migration (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005083small GTPase regulator activity ----
    GO:0005515protein binding IPI10644998
    GO:0008017microtubule binding ISS17310996
         
    MAPRE3 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mapre3):
     hematopoietic system  homeostasis/metabolism 

    MAPRE3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAPRE3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPRE3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPRE3

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAPRE3:
    hsa-mir-130b-3p (MIRT020202), hsa-mir-93-5p (MIRT028081), hsa-mir-19b-3p (MIRT031142)

    Block miRNA regulation of human, mouse, rat MAPRE3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPRE3 (see all 32):
    hsa-miR-106a hsa-miR-301a hsa-miR-3133 hsa-miR-519a hsa-miR-888* hsa-miR-93 hsa-miR-330-3p hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidMAPRE3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MAPRE3
    Predesigned siRNA for gene silencing in human, mouse, rat MAPRE3

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for MAPRE3 (see all 6)
    OriGene ORF clones in mouse, rat for MAPRE3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAPRE3 (NM_012326)
    Sino Biological Human cDNA Clone for MAPRE3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPRE3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPRE3

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPRE3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MARE3_HUMAN, Q9UPY8: Cytoplasm, cytoskeleton. Note=Associated with the microtubule network. Detected at the plus
    end of microtubules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus2
    plasma membrane2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS17310996
    GO:0005874microtubule ISS17310996
    GO:0005881cytoplasmic microtubule IDA10644998
    GO:0030496midbody ISS17310996
    GO:0048471perinuclear region of cytoplasm IDA10644998

    MAPRE3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPRE3 About    
    See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    Epithelial Adherens Junctions0.36
    2Remodeling of Adherens Junctions
    Remodeling of Adherens Junctions

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAPRE3
        Remodeling of Adherens Junctions
    Epithelial Adherens Junctions



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAPRE3
    Interactions:

        GeneGlobe Interaction Network for MAPRE3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPRE3 (Q9UPY81, 2, 3 ENSP000002331214) via UniProtKB, MINT, STRING, and/or I2D (see all 229)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB1AP628202, 3MINT-63975 I2D: score=4 
    JUNP054121, 3EBI-726739,EBI-852823 I2D: score=1 
    APC2O959961, 3, ENSP000002336074EBI-726739,EBI-1053045 I2D: score=3 STRING: ENSP00000233607
    LMO2P257912, 3, ENSP000002578184MINT-67170 I2D: score=6 STRING: ENSP00000257818
    MAPRE2Q155552, 3, ENSP000003002494MINT-67922 I2D: score=5 STRING: ENSP00000300249
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle ----
    GO:0007067mitosis IEA--
    GO:0045737positive regulation of cyclin-dependent protein kinase activity ISS17310996
    GO:0045893positive regulation of transcription, DNA-templated ISS17310996

    MAPRE3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAPRE3 (MARE3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAPRE3 gene: 
    NM_012326.2  

    Unigene Cluster for MAPRE3:

    Microtubule-associated protein, RP/EB family, member 3
    Hs.515860  [show with all ESTs]
    Unigene Representative Sequence: AB025186
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233121(uc002rhw.3) ENST00000494788 ENST00000405074 ENST00000475633(uc010yld.2)
    ENST00000481222 ENST00000491354 ENST00000474367 ENST00000458529 ENST00000402218

    miRNA
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    Block miRNA regulation of human, mouse, rat MAPRE3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPRE3 (see all 32):
    hsa-miR-106a hsa-miR-301a hsa-miR-3133 hsa-miR-519a hsa-miR-888* hsa-miR-93 hsa-miR-330-3p hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidMAPRE3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MAPRE3
    Predesigned siRNA for gene silencing in human, mouse, rat MAPRE3
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAPRE3 (NM_012326)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPRE3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPRE3
    Primer
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    OriGene qPCR primer pairs and template standards for MAPRE3
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPRE3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPRE3
      QuantiTect SYBR Green Assays in human, mouse, rat MAPRE3
      QuantiFast Probe-based Assays in human, mouse, rat MAPRE3

    Additional mRNA sequence: 

    AB025186.1 AK302950.1 AK312342.1 BC011557.1 CR536523.1 CR541845.1 Y11174.1 

    10 DOTS entries:

    DT.85105547  DT.100811501  DT.86855336  DT.120974681  DT.100811503  DT.120974705  DT.100764323  DT.100811500 
    DT.92424386  DT.97769206 

    Selected AceView cDNA sequences (see all 291):

    BU741205 BU786925 AA708009 BQ219352 BU686534 AI950333 BM709601 AI346860 
    BC011557 H03977 BU076069 AI128444 AI086479 BM676677 CA843390 AI937479 
    AI368168 AI042477 BQ632055 CB178822 AA987784 BM128315 CA774780 BM694546 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAPRE3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:                    -     -     -           -           -     -                 -                           
    SP2:                                            -           -     -                 -                           
    SP3:                                            -           -     -           -     -                           
    SP4:                    -     -     -           -                                                               
    SP5:                          -     -           -                                                               


    ECgene alternative splicing isoforms for MAPRE3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAPRE3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGGGATGG
    MAPRE3 Expression
    About this image


    MAPRE3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    MAPRE3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPRE3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515860

    UniProtKB/Swiss-Prot: MARE3_HUMAN, Q9UPY8
    Tissue specificity: Predominantly expressed in brain and muscle

        Custom PCR Arrays for MAPRE3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPRE3
    QuantiTect SYBR Green Assays in human, mouse, rat MAPRE3
    QuantiFast Probe-based Assays in human, mouse, rat MAPRE3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPRE3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAPRE3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapre31 , 5 microtubule-associated protein, RP/EB family, member more1, 5 91.81(n)1
    99.29(a)1
      5 (16.90 cM)5
    1007321  NM_133350.11  NP_579928.11 
     308146415 
    chicken
    (Gallus gallus)
    Aves LOC1008577321 microtubule-associated protein RP/EB family member more 79.37(n)
    85.64(a)
      100857732  XM_003641069.2  XP_003641117.2 
    lizard
    (Anolis carolinensis)
    Reptilia MAPRE36
    microtubule-associated protein, RP/EB family, memb...
    88(a)
    1 ↔ 1
    GL343593.1(101146-150050)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686672 hypothetical protein MGC68667 79.67(n)    BC060416.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mapre3a6
    mapre3b6
    (see all 3)
    microtubule-associated protein, RP/EB family, memb...
    microtubule-associated protein, RP/EB family, memb...
    (see all 3)
    83(a)
    81(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    17(37034799-37064078) ENSDARG00000020231
    4(492034-496267) ENSDARG00000059344
    fruit fly
    (Drosophila melanogaster)
    Insecta Eb13 microtubule-based process microtubule
    binding
    53(a)
    (best of 2)
      42C7   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y59A8B.73   -- 51(a)
    (best of 2)
      V(18046176-18054907)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BIM16
    Microtubule-binding protein that together with Kar...
    27(a)
    1 → many
    V(188277-189311) YER016W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EB1A1 EB1A 49.42(n)
    43.04(a)
      823923  NM_114637.4  NP_190353.3 


    ENSEMBL Gene Tree for MAPRE3 (if available)
    TreeFam Gene Tree for MAPRE3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAPRE3 gene
    MAPRE22  MAPRE12  
    2 SIMAP similar genes for MAPRE3 using alignment to 2 protein entries:     MARE3_HUMAN (see all proteins):
    MAPRE2    MAPRE1

    MAPRE3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAPRE3 (see all 935)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1473983061,2
    --26933738(+) GGGAGA/CTAGAC 1 -- us2k10--------
    rs1855102381,2
    --26933885(+) TAGGGG/TATGAT 1 -- us2k10--------
    rs747022771,2
    C,F--26933944(+) AGTCAC/TGGGGT 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1888548911,2
    --26934023(+) GGCGAA/GGATTC 1 -- us2k10--------
    rs1808459181,2
    --26934060(+) ATTAAA/CAGGAT 1 -- us2k10--------
    rs1860816511,2
    --26934111(+) TACTAA/CAAGAC 1 -- us2k10--------
    rs1380349521,2
    C--26934150(+) GGACTA/GGGACT 1 -- us2k10--------
    rs1434851081,2
    C--26934169(+) GTTAGC/GCCAGA 1 -- us2k10--------
    rs1922090181,2
    --26934229(+) ATTTCG/TCAGAA 1 -- us2k10--------
    rs1471424201,2
    --26934230(+) TTTCTC/TAGAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAPRE3 (27193480 - 27250087 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MAPRE3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv455974CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAPRE3
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPRE3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605788    OMIM disorders: --

    8 diseases for MAPRE3:    
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    burkitt's lymphoma    herpes simplex    colorectal cancer    tonsillitis
    malaria    cerebritis    neuronitis    thyroiditis


    MAPRE3 for disorders           About GeneDecksing


    Export disorders for MAPRE3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPRE3 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with MAPRE3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells. (PubMed id 9233623)1, 2, 3 Renner C.... Pfreundschuh M. (J. Immunol. 1997)
    2. Characterization of human MAPRE genes and their proteins. (PubMed id 11161807)1, 2, 9 Su L.-K. and Qi Y. (Genomics 2001)
    3. Mammalian end binding proteins control persistent microtubule growth. (PubMed id 19255245)1, 2, 9 Komarova Y.... Akhmanova A. (J. Cell Biol. 2009)
    4. Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. (PubMed id 19146815)1, 2 Jaworski J.... Hoogenraad C.C. (Neuron 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Characterization of functional domains of human EB1 family proteins. (PubMed id 14514668)1, 2 Bu W. and Su L.-K. (J. Biol. Chem. 2003)
    7. EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue. (PubMed id 10644998)1, 2 Nakagawa H.... Nakamura Y. (Oncogene 2000)
    8. EB/RP gene family encodes tubulin binding proteins. (PubMed id 10188731)1, 2 Juwana J.-P.... Renner C. (Int. J. Cancer 1999)
    9. Mitotic regulation of the stability of microtubule plus-end tracking protein EB3 by ubiquitin ligase SIAH-1 and Aurora mitotic kinases. (PubMed id 19696028)1, 9 Ban R....Urano T. (J. Biol. Chem. 2009)
    10. Molecular insights into mammalian end-binding protein heterodimerization. (PubMed id 20008324)1, 9 De Groot C.O....Steinmetz M.O. (J. Biol. Chem. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22924 HGNC: 6892 AceView: MAPRE3 Ensembl:ENSG00000084764 euGenes: HUgn22924
    ECgene: MAPRE3 H-InvDB: MAPRE3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAPRE3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPRE3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAPRE3 gene:
    Search GeneIP for patents involving MAPRE3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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