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Aliases for MAPRE3 Gene

Aliases for MAPRE3 Gene

  • Microtubule Associated Protein RP/EB Family Member 3 2 3 5
  • EB1 Protein Family Member 3 3 4
  • End-Binding Protein 3 3 4
  • EBF3 3 4
  • RP3 3 4
  • EB3 3 4
  • Microtubule-Associated Protein, RP/EB Family, Member 3 3
  • APC Binding Protein 3
  • EBF3-S 3

External Ids for MAPRE3 Gene

Previous GeneCards Identifiers for MAPRE3 Gene

  • GC02P027114
  • GC02P027286
  • GC02P027168
  • GC02P027105
  • GC02P027193

Summaries for MAPRE3 Gene

Entrez Gene Summary for MAPRE3 Gene

  • The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPRE3 Gene

MAPRE3 (Microtubule Associated Protein RP/EB Family Member 3) is a Protein Coding gene. Diseases associated with MAPRE3 include adenomatous polyposis coli and mature b-cell neoplasm. Among its related pathways are PAK Pathway and Remodeling of Adherens Junctions. GO annotations related to this gene include microtubule binding. An important paralog of this gene is MAPRE2.

UniProtKB/Swiss-Prot for MAPRE3 Gene

  • Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).

Gene Wiki entry for MAPRE3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPRE3 Gene

Genomics for MAPRE3 Gene

Regulatory Elements for MAPRE3 Gene

Promoters for MAPRE3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAPRE3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAPRE3 Gene

Chromosome:
2
Start:
26,970,371 bp from pter
End:
27,027,219 bp from pter
Size:
56,849 bases
Orientation:
Plus strand

Genomic View for MAPRE3 Gene

Genes around MAPRE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPRE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPRE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPRE3 Gene

Proteins for MAPRE3 Gene

  • Protein details for MAPRE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPY8-MARE3_HUMAN
    Recommended name:
    Microtubule-associated protein RP/EB family member 3
    Protein Accession:
    Q9UPY8
    Secondary Accessions:
    • B7WPK5
    • O00265
    • Q6FHB0
    • Q6FI15
    • Q9BZP7
    • Q9BZP8

    Protein attributes for MAPRE3 Gene

    Size:
    281 amino acids
    Molecular mass:
    31982 Da
    Quaternary structure:
    • Interacts with APC2 (By similarity). Homodimer. Heterodimer with MAPRE1. Interacts with DCTN1 and SRCIN1. Binds to the C-terminal domain of APC. Binds monomeric and polymerized tubulin. Interacts (via C-terminus) with CLIP1. Interacts with SLAIN2.
    SequenceCaution:
    • Sequence=AAK07556.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK07557.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA72060.1; Type=Frameshift; Positions=199; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAPRE3 Gene

    Alternative splice isoforms for MAPRE3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPRE3 Gene

Proteomics data for MAPRE3 Gene at MOPED

Post-translational modifications for MAPRE3 Gene

  • Ubiquitination at Lys 229
  • Modification sites at PhosphoSitePlus

Other Protein References for MAPRE3 Gene

Antibody Products

No data available for DME Specific Peptides for MAPRE3 Gene

Domains & Families for MAPRE3 Gene

Protein Domains for MAPRE3 Gene

Suggested Antigen Peptide Sequences for MAPRE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UPY8

UniProtKB/Swiss-Prot:

MARE3_HUMAN :
  • Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.
  • Belongs to the MAPRE family.
Domain:
  • Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 EB1 C-terminal domain.
Family:
  • Belongs to the MAPRE family.
genes like me logo Genes that share domains with MAPRE3: view

No data available for Gene Families for MAPRE3 Gene

Function for MAPRE3 Gene

Molecular function for MAPRE3 Gene

UniProtKB/Swiss-Prot Function:
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).
genes like me logo Genes that share phenotypes with MAPRE3: view

Animal Models for MAPRE3 Gene

MGI Knock Outs for MAPRE3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPRE3 Gene

Localization for MAPRE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPRE3 Gene

Cytoplasm, cytoskeleton. Note=Associated with the microtubule network. Detected at the plus end of microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPRE3 Gene COMPARTMENTS Subcellular localization image for MAPRE3 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MAPRE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035371 microtubule plus-end IEA --
genes like me logo Genes that share ontologies with MAPRE3: view

Pathways & Interactions for MAPRE3 Gene

genes like me logo Genes that share pathways with MAPRE3: view

Pathways by source for MAPRE3 Gene

SIGNOR curated interactions for MAPRE3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAPRE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity ISS 17310996
genes like me logo Genes that share ontologies with MAPRE3: view

Drugs & Compounds for MAPRE3 Gene

No Compound Related Data Available

Transcripts for MAPRE3 Gene

Unigene Clusters for MAPRE3 Gene

Microtubule-associated protein, RP/EB family, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPRE3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - -
SP6:
SP7: - - -

Relevant External Links for MAPRE3 Gene

GeneLoc Exon Structure for
MAPRE3
ECgene alternative splicing isoforms for
MAPRE3

Expression for MAPRE3 Gene

mRNA expression in normal human tissues for MAPRE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAPRE3 Gene

This gene is overexpressed in Frontal cortex (19.4), Brain (13.8), Fetal Brain (11.9), and Retina (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPRE3 Gene



SOURCE GeneReport for Unigene cluster for MAPRE3 Gene Hs.515860

mRNA Expression by UniProt/SwissProt for MAPRE3 Gene

Q9UPY8-MARE3_HUMAN
Tissue specificity: Predominantly expressed in brain and muscle.
genes like me logo Genes that share expression patterns with MAPRE3: view

Protein tissue co-expression partners for MAPRE3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MAPRE3 Gene

Orthologs for MAPRE3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAPRE3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAPRE3 35
  • 94.49 (n)
  • 99.62 (a)
MAPRE3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPRE3 35
  • 94.9 (n)
  • 99.64 (a)
MAPRE3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapre3 35
  • 91.81 (n)
  • 99.29 (a)
Mapre3 16
Mapre3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapre3 35
  • 92.88 (n)
  • 99.29 (a)
oppossum
(Monodelphis domestica)
Mammalia MAPRE3 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPRE3 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAPRE3 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857732 35
  • 79.37 (n)
  • 85.64 (a)
MAPRE3 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPRE3 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68667 35
zebrafish
(Danio rerio)
Actinopterygii mapre3a 36
  • 83 (a)
OneToMany
mapre3b 36
  • 81 (a)
OneToMany
mapre3b 36
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG18190 37
  • 34 (a)
Eb1 37
  • 53 (a)
Eb1 36
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea VW02B12L.3 37
  • 34 (a)
Y59A8B.7 37
  • 51 (a)
ebp-1 36
  • 40 (a)
ManyToMany
ebp-2 36
  • 31 (a)
ManyToMany
ebp-3 36
  • 28 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BIM1 36
  • 27 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons EB1A 35
  • 49.42 (n)
  • 43.04 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4467 35
Species with no ortholog for MAPRE3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MAPRE3 Gene

ENSEMBL:
Gene Tree for MAPRE3 (if available)
TreeFam:
Gene Tree for MAPRE3 (if available)

Paralogs for MAPRE3 Gene

Paralogs for MAPRE3 Gene

(2) SIMAP similar genes for MAPRE3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MAPRE3: view

Variants for MAPRE3 Gene

Sequence variations from dbSNP and Humsavar for MAPRE3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10224 -- 27,025,895(-) TGTCA(A/G)CTTCA reference, synonymous-codon
rs12328 -- 27,026,573(+) ACCCA(C/T)CCTAT utr-variant-3-prime
rs14628 -- 27,025,901(-) ATCCA(A/C)TGTCA reference, missense
rs893790 -- 26,978,989(+) AAGAG(C/T)TGGAC intron-variant
rs1058547 -- 27,022,256(+) CAGTG(A/G/T)AAATC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MAPRE3 Gene

Variant ID Type Subtype PubMed ID
nsv455974 CNV Loss 19166990

Variation tolerance for MAPRE3 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPRE3 Gene

HapMap Linkage Disequilibrium report
MAPRE3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPRE3 Gene

Disorders for MAPRE3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAPRE3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
adenomatous polyposis coli
  • brain tumor-polyposis syndrome 2
mature b-cell neoplasm
  • mature b-cell lymphocytic neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAPRE3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPRE3
genes like me logo Genes that share disorders with MAPRE3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPRE3 Gene

Publications for MAPRE3 Gene

  1. RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells. (PMID: 9233623) Renner C. … Pfreundschuh M. (J. Immunol. 1997) 2 3 4 67
  2. Molecular insights into mammalian end-binding protein heterodimerization. (PMID: 20008324) De Groot C.O. … Steinmetz M.O. (J. Biol. Chem. 2010) 3 23
  3. Mammalian end binding proteins control persistent microtubule growth. (PMID: 19255245) Komarova Y. … Akhmanova A. (J. Cell Biol. 2009) 3 23
  4. Mitotic regulation of the stability of microtubule plus-end tracking protein EB3 by ubiquitin ligase SIAH-1 and Aurora mitotic kinases. (PMID: 19696028) Ban R. … Urano T. (J. Biol. Chem. 2009) 3 23
  5. Characterization of human MAPRE genes and their proteins. (PMID: 11161807) Su L.-K. … Qi Y. (Genomics 2001) 3 23

Products for MAPRE3 Gene

Sources for MAPRE3 Gene

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