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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPRE3 Gene

protein-coding   GIFtS: 59
GCID: GC02P027193

Microtubule-Associated Protein, RP/EB Family, Member 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Microtubule-Associated Protein, RP/EB Family, Member 31 2     EB1 Protein Family Member 32 3
EB32 3 5     EBF3-S2
EBF32 3 5     APC Binding Protein2
RP32 3 5     Microtubule-Associated Protein RP/EB Family Member 32
End-Binding Protein 32 3     

External Ids:    HGNC: 68921   Entrez Gene: 229242   Ensembl: ENSG000000847647   OMIM: 6057885   UniProtKB: Q9UPY83   

Export aliases for MAPRE3 gene to outside databases

Previous GC identifers: GC02P027114 GC02P027286 GC02P027168 GC02P027105 GC02P026935


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAPRE3 Gene:
The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the
cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAPRE3 Gene: 
MAPRE3 (microtubule-associated protein, RP/EB family, member 3) is a protein-coding gene. Diseases associated with MAPRE3 include herpes simplex, and burkitt's lymphoma, and among its related super-pathways are PAK Pathway. GO annotations related to this gene include microtubule binding and small GTPase regulator activity. An important paralog of this gene is MAPRE2.

UniProtKB/Swiss-Prot: MARE3_HUMAN, Q9UPY8
Function: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton.
Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them
at centrosomes. May play a role in cell migration (By similarity)

Gene Wiki entry for MAPRE3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPRE3 gene promoter:
         MEF-2A   Sox5   Pax-5   AML1a   FOXO1a   aMEF-2   NF-kappaB1   Ik-3   LCR-F1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAPRE3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAPRE3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPRE3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3-p23.1   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3-p23.1

MAPRE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPRE3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P027193:  view genomic region     (about GC identifiers)

Start:
27,193,480 bp from pter      End:
27,250,087 bp from pter
Size:
56,608 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MARE3_HUMAN, Q9UPY8 (See protein sequence)
Recommended Name: Microtubule-associated protein RP/EB family member 3  
Size: 281 amino acids; 31982 Da
Subunit: Interacts with APC2 (By similarity). Homodimer. Heterodimer with MAPRE1. Interacts with DCTN1 and SRCIN1.
Binds to the C-terminal domain of APC. Binds monomeric and polymerized tubulin. Interacts (via C-terminus) with
CLIP1. Interacts with SLAIN2
Subcellular location: Cytoplasm, cytoskeleton. Note=Associated with the microtubule network. Detected at the plus
end of microtubules
Sequence caution: Sequence=AAK07556.1; Type=Erroneous initiation; Sequence=AAK07557.1; Type=Erroneous initiation;
Sequence=CAA72060.1; Type=Frameshift; Positions=199;
3 PDB 3D structures from and Proteopedia for MAPRE3:
1WYO (3D)        3CO1 (3D)        3TQ7 (3D)    
Secondary accessions: B7WPK5 O00265 Q6FHB0 Q6FI15 Q9BZP7 Q9BZP8
Alternative splicing: 2 isoforms:  Q9UPY8-1   Q9UPY8-2   

Explore the universe of human proteins at neXtProt for MAPRE3: NX_Q9UPY8

Explore proteomics data for MAPRE3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UPY8

  • MAPRE3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAPRE3 Protein Expression
    REFSEQ proteins: NP_036458.2  
    ENSEMBL proteins: 
     ENSP00000233121   ENSP00000383915   ENSP00000391705   ENSP00000385715  

    Human Recombinant Protein Products for MAPRE3: 
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    Novus Biologicals MAPRE3 Proteins
    Novus Biologicals MAPRE3 Lysates
    Sino Biological Recombinant Protein for MAPRE3
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MAPRE3
    Cloud-Clone Corp. Proteins for MAPRE3 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS17310996
    GO:0005874microtubule ISS17310996
    GO:0005881cytoplasmic microtubule IDA10644998
    GO:0030496midbody ISS17310996
    GO:0048471perinuclear region of cytoplasm IDA10644998

    MAPRE3 for ontologies           About GeneDecksing



    MAPRE3 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for MAPRE3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001715 CH-domain
     IPR027328 MAPRE
     IPR004953 EB1_C

    Graphical View of Domain Structure for InterPro Entry Q9UPY8

    ProtoNet protein and cluster: Q9UPY8

    2 Blocks protein domains:
    IPB001715 Calponin-like actin-binding
    IPB004953 EB1 protein


    UniProtKB/Swiss-Prot: MARE3_HUMAN, Q9UPY8
    Domain: Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved
    in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC
    and DCTN1
    Similarity: Belongs to the MAPRE family
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 EB1 C-terminal domain


    MAPRE3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARE3_HUMAN, Q9UPY8
    Function: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton.
    Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them
    at centrosomes. May play a role in cell migration (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005083small GTPase regulator activity NAS--
    GO:0005515protein binding IPI10644998
    GO:0008017microtubule binding ISS17310996
         
    MAPRE3 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mapre3):
     hematopoietic system  homeostasis/metabolism 

    MAPRE3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAPRE3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAPRE3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPRE3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPRE3 

    miRNA
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    hsa-miR-106a hsa-miR-301a hsa-miR-3133 hsa-miR-519a hsa-miR-888* hsa-miR-93 hsa-miR-330-3p hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidMAPRE3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPRE3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAPRE3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    Epithelial Adherens Junctions0.36
    2Remodeling of Adherens Junctions
    Remodeling of Adherens Junctions

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPRE3
        Remodeling of Adherens Junctions
    Epithelial Adherens Junctions



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPRE3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for MAPRE3 (Q9UPY81, 2, 3 ENSP000002331214) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LMO2P257912, 3, ENSP000002578184MINT-67170 I2D: score=6 STRING: ENSP00000257818
    RAB1AP628202, 3MINT-63975 I2D: score=4 
    JUNP054121, 3EBI-726739,EBI-852823 I2D: score=1 
    MAPRE2Q155552, 3, ENSP000003002494MINT-67922 I2D: score=5 STRING: ENSP00000300249
    CLASP1Q7Z4603, ENSP000002637104I2D: score=3 STRING: ENSP00000263710
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle ISS17310996
    GO:0007067mitosis IEA--
    GO:0045893positive regulation of transcription, DNA-dependent ISS17310996
    GO:0051301cell division IEA--

    MAPRE3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAPRE3 (MARE3)

    Search CenterWatch for drugs/clinical trials and news about MAPRE3 / MARE3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAPRE3 gene: 
    NM_012326.2  

    Unigene Cluster for MAPRE3:

    Microtubule-associated protein, RP/EB family, member 3
    Hs.515860  [show with all ESTs]
    Unigene Representative Sequence: AB025186
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233121(uc002rhw.3) ENST00000494788 ENST00000405074 ENST00000475633(uc010yld.2)
    ENST00000481222 ENST00000491354 ENST00000474367 ENST00000458529 ENST00000402218

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    hsa-miR-106a hsa-miR-301a hsa-miR-3133 hsa-miR-519a hsa-miR-888* hsa-miR-93 hsa-miR-330-3p hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidMAPRE3 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB025186.1 AK302950.1 AK312342.1 BC011557.1 CR536523.1 CR541845.1 Y11174.1 

    10 DOTS entries:

    DT.85105547  DT.100811501  DT.86855336  DT.120974681  DT.100811503  DT.120974705  DT.100764323  DT.100811500 
    DT.92424386  DT.97769206 

    24/291 AceView cDNA sequences (see all 291):

    H03977 AA757439 BM726937 BF115307 AA448655 BU741205 BU686534 CB177843 
    AA708009 AI148618 CB178690 AI950333 AI086479 AI343940 BU076069 BM701401 
    BM694546 BM700297 AW028772 BM544345 AA987784 AI937479 BQ632055 AI042477 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MAPRE3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:                    -     -     -           -           -     -                 -                           
    SP2:                                            -           -     -                 -                           
    SP3:                                            -           -     -           -     -                           
    SP4:                    -     -     -           -                                                               
    SP5:                          -     -           -                                                               


    ECgene alternative splicing isoforms for MAPRE3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPRE3 expression in normal human tissues (normalized intensities)      MAPRE3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGGGATGG
    MAPRE3 Expression
    About this image


    MAPRE3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             caudate nucleus   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             reticulocytes   
     
     Colon (Gastrointestinal Tract)
             colon ; peripheral nerve/ganglion   
     
     Peripheral Nervous System (Nervous System)
             colon ; peripheral nerve/ganglion   
     
     Nose (Sensory Organs)
             nasopharynx ; respiratory epithelial cells   

    See MAPRE3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPRE3

    SOURCE GeneReport for Unigene cluster: Hs.515860

    UniProtKB/Swiss-Prot: MARE3_HUMAN, Q9UPY8
    Tissue specificity: Predominantly expressed in brain and muscle

        SABiosciences Custom PCR Arrays for MAPRE3
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPRE3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPRE3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAPRE3 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapre31 , 5 microtubule-associated protein, RP/EB family, member more1, 5 91.81(n)1
    99.29(a)1
      5 (16.90 cM)5
    1007321  NM_133350.11  NP_579928.11 
     308146415 
    chicken
    (Gallus gallus)
    Aves MAPRE36
    microtubule-associated protein, RP/EB family, memb...
    60(a)
    1 ↔ 1
    3(104213713-104218289)
    lizard
    (Anolis carolinensis)
    Reptilia MAPRE36
    microtubule-associated protein, RP/EB family, memb...
    87(a)
    1 ↔ 1
    GL343593.1(101146-150050)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686672 hypothetical protein MGC68667 79.67(n)    BC060416.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mapre3a1 microtubule-associated protein, RP/EB family, member more 75.16(n)
    83.4(a)
      559217  NM_001030127.1  NP_001025298.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eb11 , 3 microtubule-based process microtubule
    binding3
    CG3265-PA1
    53(a)
    (best of 2)3
    58.74(n)1
    57.25(a)1
      42C73
    355841  NM_165487.31  NP_724495.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y59A8B.73   -- 51(a)
    (best of 2)
      V(18046176-18054907)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BIM16
    Microtubule-binding protein that together with Kar...
    24(a)
    1 → many
    V(188277-189311)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EB1A1 microtubule end binding protein EB1A 49.42(n)
    43.04(a)
      823923  NM_114637.4  NP_190353.3 


    ENSEMBL Gene Tree for MAPRE3 (if available)
    TreeFam Gene Tree for MAPRE3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPRE3 gene
    MAPRE22  MAPRE12  
    2 SIMAP similar genes for MAPRE3 using alignment to 2 protein entries:     MARE3_HUMAN (see all proteins):
    MAPRE2    MAPRE1

    MAPRE3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/935 SNPs in MAPRE3 are shown (see all 935)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1473983061,2
    --26933738(+) GGGAGA/CTAGAC 1 -- us2k10--------
    rs1855102381,2
    --26933885(+) TAGGGG/TATGAT 1 -- us2k10--------
    rs747022771,2
    C,F--26933944(+) AGTCAC/TGGGGT 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1888548911,2
    --26934023(+) GGCGAA/GGATTC 1 -- us2k10--------
    rs1808459181,2
    --26934060(+) ATTAAA/CAGGAT 1 -- us2k10--------
    rs1860816511,2
    --26934111(+) TACTAA/CAAGAC 1 -- us2k10--------
    rs1380349521,2
    C--26934150(+) GGACTA/GGGACT 1 -- us2k10--------
    rs1434851081,2
    C--26934169(+) GTTAGC/GCCAGA 1 -- us2k10--------
    rs1922090181,2
    --26934229(+) ATTTCG/TCAGAA 1 -- us2k10--------
    rs1471424201,2
    --26934230(+) TTTCTC/TAGAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAPRE3 (27193480 - 27250087 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MAPRE3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv455974CNV Loss19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MAPRE3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605788    OMIM disorders: --

    4 diseases for MAPRE3:    About MalaCards
    herpes simplex    burkitt's lymphoma    colorectal cancer    neuronitis


    MAPRE3 for disorders           About GeneDecksing


    Export disorders for MAPRE3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPRE3 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with MAPRE3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells. (PubMed id 9233623)1, 2, 3 Renner C.... Pfreundschuh M. (1997)
    2. Characterization of human MAPRE genes and their proteins. (PubMed id 11161807)1, 2, 9 Su L.-K. and Qi Y. (2001)
    3. Mammalian end binding proteins control persistent microtubule growth. (PubMed id 19255245)1, 2, 9 Komarova Y....Akhmanova A. (2009)
    4. Dynamic microtubules regulate dendritic spine morphol ogy and synaptic plasticity. (PubMed id 19146815)1, 2 Jaworski J....Hoogenraad C.C. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Characterization of functional domains of human EB1 family proteins. (PubMed id 14514668)1, 2 Bu W. and Su L.-K. (2003)
    7. EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue. (PubMed id 10644998)1, 2 Nakagawa H.... Nakamura Y. (2000)
    8. EB/RP gene family encodes tubulin binding proteins. (PubMed id 10188731)1, 2 Juwana J.-P.... Renner C. (1999)
    9. Mitotic regulation of the stability of microtubule pl us-end tracking protein EB3 by ubiquitin ligase SIAH-1 and Aurora mitotic kinas es. (PubMed id 19696028)1, 9 Ban R....Urano T. (2009)
    10. Molecular insights into mammalian end-binding protein heterodimerization. (PubMed id 20008324)1, 9 De Groot C.O....Steinmetz M.O. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22924 HGNC: 6892 AceView: MAPRE3 Ensembl:ENSG00000084764 euGenes: HUgn22924
    ECgene: MAPRE3 H-InvDB: MAPRE3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPRE3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPRE3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAPRE3 gene:
    Search GeneIP for patents involving MAPRE3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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