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MAPRE2 Gene

protein-coding   GIFtS: 65
GCID: GC18P032556

Microtubule-Associated Protein, RP/EB Family, Member 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microtubule-Associated Protein, RP/EB Family, Member 21 2     APC-Binding Protein EB22 3
EB22 3 5     EB12
RP12 3 5     Microtubule-Associated Protein RP/EB Family Member 22
APC-Binding Protein EB11 2     T-Cell Activation Protein, EB1 Family2
End-Binding Protein 22 3     

External Ids:    HGNC: 68911   Entrez Gene: 109822   Ensembl: ENSG000001669747   OMIM: 6057895   UniProtKB: Q155553   

Export aliases for MAPRE2 gene to outside databases

Previous GC identifers: GC18P032655 GC18P032440 GC18P030873 GC18P030875 GC18P029416


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPRE2 Gene:
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC)
protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle
symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the
proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants.
(provided by RefSeq, Jan 2012)

GeneCards Summary for MAPRE2 Gene:
MAPRE2 (microtubule-associated protein, RP/EB family, member 2) is a protein-coding gene. Diseases associated with MAPRE2 include colorectal cancer, and familial adenomatous polyposis. GO annotations related to this gene include microtubule binding. An important paralog of this gene is MAPRE3.

UniProtKB/Swiss-Prot: MARE2_HUMAN, Q15555
Function: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and
anchoring them at centrosomes. May play a role in cell migration (By similarity)

Gene Wiki entry for MAPRE2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPRE2 gene promoter:
         HEN1   AREB6   NF-1   Chx10   CUTL1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): MAPRE2 promoter sequence
   Search Chromatin IP Primers for MAPRE2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPRE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.1   Ensembl cytogenetic band:  18q12.1   HGNC cytogenetic band: 18q12.1

MAPRE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPRE2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P032556:  view genomic region     (about GC identifiers)

Start:
32,556,892 bp from pter      End:
32,723,434 bp from pter
Size:
166,543 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MARE2_HUMAN, Q15555 (See protein sequence)
Recommended Name: Microtubule-associated protein RP/EB family member 2  
Size: 327 amino acids; 37031 Da
Subunit: Interacts with DCTN1. Binds to the C-terminal domain of APC. Binds monomeric and polymerized tubulin
Sequence caution: Sequence=BAA83375.1; Type=Erroneous initiation;
Secondary accessions: B2RE21 B3KR39 B7Z2L3 E9PHR3 F5H1V8 Q9UQ33
Alternative splicing: 4 isoforms:  Q15555-1   Q15555-2   Q15555-3   Q15555-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAPRE2: NX_Q15555

Explore proteomics data for MAPRE2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys156, Lys165, Lys271
  • Modification sites at PhosphoSitePlus

  • See MAPRE2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001137298.1  NP_001137299.1  NP_001243349.1  NP_055083.1  

    ENSEMBL proteins: 
     ENSP00000468216   ENSP00000465939   ENSP00000466871   ENSP00000407723   ENSP00000468904  
     ENSP00000300249   ENSP00000446343   ENSP00000468588   ENSP00000464921   ENSP00000396074  

    MAPRE2 Human Recombinant Protein Products:

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    Novus Biologicals MAPRE2 Proteins
    Novus Biologicals MAPRE2 Lysates
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    ProSpec Recombinant Protein for MAPRE2
    Cloud-Clone Corp. Proteins for MAPRE2

    MAPRE2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for MAPRE2

    MAPRE2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for MAPRE2
    Cloud-Clone Corp. CLIAs for MAPRE2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR027735 RP1/EB2
     IPR001715 CH-domain
     IPR027328 MAPRE
     IPR004953 EB1_C

    Graphical View of Domain Structure for InterPro Entry Q15555

    ProtoNet protein and cluster: Q15555

    2 Blocks protein domains:
    IPB001715 Calponin-like actin-binding
    IPB004953 EB1 protein


    UniProtKB/Swiss-Prot: MARE2_HUMAN, Q15555
    Domain: Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved
    in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC
    and DCTN1
    Similarity: Belongs to the MAPRE family
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 EB1 C-terminal domain


    MAPRE2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARE2_HUMAN, Q15555
    Function: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and
    anchoring them at centrosomes. May play a role in cell migration (By similarity)

         Genatlas biochemistry entry for MAPRE2:
    microtubule-associated protein,RP/EB family,member 2,highly homolog to MAPRE1,APC binding gene
    family,differentially expressed in activated T cells,putatively belonging to the immediate/early gene
    family,which controls the signal transduction cascade downstream of the TCR,may be involved in the tumorigenesis
    of colorectal cancers but may also play a role in the proliferative control of normal cells

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008017microtubule binding IEA--
         
    MAPRE2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MAPRE2:
     Decreased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAPRE2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAPRE2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPRE2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPRE2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAPRE2:
    hsa-mir-204-5p (MIRT005836), hsa-mir-455-3p (MIRT037823)

    Block miRNA regulation of human, mouse, rat MAPRE2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPRE2 (see all 50):
    hsa-miR-300 hsa-miR-128 hsa-miR-200a hsa-miR-29a hsa-miR-1260b hsa-miR-578 hsa-miR-3074-3p hsa-miR-766
    SwitchGear 3'UTR luciferase reporter plasmidMAPRE2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAPRE2
    Predesigned siRNA for gene silencing in human, mouse, rat MAPRE2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAPRE2

    Clone
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    OriGene clones in human, mouse for MAPRE2 (see all 16)
    OriGene ORF clones in mouse, rat for MAPRE2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MAPRE2 (NM_001143827)
    Sino Biological Human cDNA Clone for MAPRE2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPRE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPRE2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MAPRE2
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAPRE2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPRE2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MARE2_HUMAN, Q15555: Cytoplasm, cytoskeleton. Note=Associated with the microtubule network. Accumulates at the
    plus end of microtubules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule IEA--
    GO:0015630microtubule cytoskeleton IDA--

    MAPRE2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPRE2 About    
    See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    Epithelial Adherens Junctions0.36
    2Remodeling of Adherens Junctions
    Remodeling of Adherens Junctions

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAPRE2
        Remodeling of Adherens Junctions
    Epithelial Adherens Junctions



        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPRE2: 
              Cytoskeleton Regulators in human mouse rat
              Adherens Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAPRE2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPRE2 (Q155552, 3 ENSP000003002494) via UniProtKB, MINT, STRING, and/or I2D (see all 170)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LMO2P257912, 3, ENSP000002578184MINT-66036 I2D: score=5 STRING: ENSP00000257818
    MAPRE3Q9UPY82, 3, ENSP000002331214MINT-67922 I2D: score=5 STRING: ENSP00000233121
    NIF3L1Q9GZT82, 3, ENSP000003863944MINT-67424 I2D: score=5 STRING: ENSP00000386394
    APCP250543, ENSP000002574304I2D: score=1 STRING: ENSP00000257430
    PHLDA3Q9Y5J53, ENSP000003562784I2D: score=1 STRING: ENSP00000356278
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis IEA--
    GO:0007165signal transduction TAS9233623
    GO:0008283cell proliferation TAS9233623

    MAPRE2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAPRE2 (MARE2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAPRE2 gene (4 alternative transcripts): 
    NM_001143826.2  NM_001143827.2  NM_001256420.1  NM_014268.3  

    Unigene Cluster for MAPRE2:

    Microtubule-associated protein, RP/EB family, member 2
    Hs.532824  [show with all ESTs]
    Unigene Representative Sequence: NM_001143827
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000591734 ENST00000589180 ENST00000590793 ENST00000587359 ENST00000436190(uc010xcc.2)
    ENST00000588349 ENST00000300249(uc002kyf.2 uc002kyg.3 uc002kyh.3 uc010xcd.2)
    ENST00000538170 ENST00000588910 ENST00000585592 ENST00000589699 ENST00000588085
    ENST00000413393(uc010xcb.2)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MAPRE2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPRE2 (see all 50):
    hsa-miR-300 hsa-miR-128 hsa-miR-200a hsa-miR-29a hsa-miR-1260b hsa-miR-578 hsa-miR-3074-3p hsa-miR-766
    SwitchGear 3'UTR luciferase reporter plasmidMAPRE2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MAPRE2
    Predesigned siRNA for gene silencing in human, mouse, rat MAPRE2
    Clone
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    OriGene clones in human, mouse for MAPRE2 (see all 16)
    OriGene ORF clones in mouse, rat for MAPRE2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MAPRE2 (NM_001143827)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPRE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPRE2
    Primer
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    OriGene qPCR primer pairs and template standards for MAPRE2
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPRE2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPRE2
      QuantiTect SYBR Green Assays in human, mouse, rat MAPRE2
      QuantiFast Probe-based Assays in human, mouse, rat MAPRE2

    Additional mRNA sequence: 

    AB016823.1 AK090945.1 AK294833.1 AK296251.1 AK315766.1 BC007318.2 BT020086.1 CR536545.1 
    NR_046177.1 U90437.1 X94232.1 

    16 DOTS entries:

    DT.449645  DT.100658664  DT.91935975  DT.100658659  DT.100849633  DT.101965704  DT.95256923  DT.101980771 
    DT.121097184  DT.121097218  DT.100641597  DT.95256927  DT.100644918  DT.91864725  DT.95256928  DT.75175813 

    Selected AceView cDNA sequences (see all 335):

    Z38725 BX493438 BP365371 T33659 BM720228 AA912397 AL601280 BG741762 
    AI520997 AW151749 CD367646 BQ718293 AV709636 AA234084 BM475609 AI217283 
    BM989577 AL536492 BP344065 AA970508 AA232674 BX457144 BM680618 AI581022 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MAPRE2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
    SP1:                                            -               
    SP2:                    -                       -               
    SP3:                                                            


    ECgene alternative splicing isoforms for MAPRE2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAPRE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAATTCATA
    MAPRE2 Expression
    About this image


    MAPRE2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Arteries
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
    MAPRE2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPRE2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532824

    UniProtKB/Swiss-Prot: MARE2_HUMAN, Q15555
    Tissue specificity: Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPRE2: 
              Cytoskeleton Regulators in human mouse rat
              Adherens Junctions in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MAPRE2
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPRE2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPRE2
    QuantiTect SYBR Green Assays in human, mouse, rat MAPRE2
    QuantiFast Probe-based Assays in human, mouse, rat MAPRE2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPRE2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAPRE2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapre25 microtubule-associated protein, RP/EB family, member more   --   18 (12.08 cM) 23752333 
    chicken
    (Gallus gallus)
    Aves MAPRE21 microtubule-associated protein, RP/EB family, member more 86.31(n)
    93.1(a)
      421105  NM_001031017.1  NP_001026188.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAPRE26
    microtubule-associated protein, RP/EB family, memb...
    93(a)
    1 ↔ 1
    GL343207.1(1974442-2017301)
    African clawed frog
    (Xenopus laevis)
    Amphibia mapre2-A2 microtubule-associated protein, RP/EB family, member more 83.48(n)    BC044671.1 
    zebrafish
    (Danio rerio)
    Actinopterygii MAPRE26
    microtubule-associated protein, RP/EB family, memb...
    74(a)
    1 ↔ 1
    24(37175601-37204029) ENSDARG00000028771
    fruit fly
    (Drosophila melanogaster)
    Insecta Eb13 microtubule-based process microtubule
    binding
    47(a)
    (best of 2)
      42C7   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y59A8B.73   -- 46(a)
    (best of 2)
      V(18046176-18054907)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BIM16
    Microtubule-binding protein that together with Kar...
    25(a)
    1 → many
    V(188277-189311) YER016W


    ENSEMBL Gene Tree for MAPRE2 (if available)
    TreeFam Gene Tree for MAPRE2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAPRE2 gene
    MAPRE32  MAPRE12  
    2 SIMAP similar genes for MAPRE2 using alignment to 6 protein entries:     MARE2_HUMAN (see all proteins):
    MAPRE3    MAPRE1

    MAPRE2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAPRE2 (see all 3184)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1910836641,2
    --32554899(+) TCTTTC/TGGGTA 1 -- us2k10--------
    rs1175633961,2
    C,F--32555044(+) GGTACG/AGATTC 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs4897441,2
    C,F,O,A,H--32555153(+) GGAAAT/CACTCA 1 -- us2k118Minor allele frequency- C:0.38MN NS EA NA WA 1392
    rs1822672171,2
    --32555174(+) ACAGAC/GAGAGA 1 -- us2k10--------
    rs1849380791,2
    --32555258(+) ATCTTC/TATTAA 1 -- us2k10--------
    rs1167075581,2
    F--32555318(+) TGTACT/CAAACC 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1431717251,2
    --32555385(+) CTGGAC/TATTAT 1 -- us2k10--------
    rs1909255021,2
    C--32555388(+) GACATC/TATCTG 1 -- us2k10--------
    rs1389448151,2
    --32555414(+) TGATTC/TTTTAA 1 -- us2k10--------
    rs1830701771,2
    --32555424(+) ATTCAA/GTGTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAPRE2 (32556892 - 32723434 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MAPRE2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2362277CNV Deletion18987734
    esv2458354CNV Deletion19546169
    esv2676768CNV Deletion23128226
    esv2716954CNV Deletion23290073
    nsv132225CNV Loss16902084
    dgv3406n71CNV Loss21882294
    esv7024CNV Loss19470904
    nsv516682CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAPRE2
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPRE2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 605789    OMIM disorders: --

    16 diseases for MAPRE2:    
    About MalaCards
    colorectal cancer    familial adenomatous polyposis    eye disease    burkitt's lymphoma
    esophageal squamous cell carcinoma    herpes simplex    squamous cell carcinoma    esophagitis
    parkinson's disease    pancreatic cancer    tonsillitis    pancreatitis
    retinitis    endotheliitis    breast cancer    cerebritis

    1 disease from the University of Copenhagen DISEASES database for MAPRE2:
    Burkitt's lymphoma

    MAPRE2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    4 Novoseek inferred disease relationships for MAPRE2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    familial adenomatous polyposis 67.3 4 11470413 (1), 11857735 (1), 9233623 (1), 16763565 (1)
    ebv infections 35.6 1 10725330 (1)
    colorectal cancer 12.8 2 9233623 (1), 11593399 (1)
    herpes simplex 11.3 3 16500893 (1), 12208942 (1)

    Genetic Association Database (GAD): MAPRE2
    Human Genome Epidemiology (HuGE) Navigator: MAPRE2 (1 document)

    Export disorders for MAPRE2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPRE2 gene, integrated from 10 sources (see all 96):
    (articles sorted by number of sources associating them with MAPRE2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells. (PubMed id 9233623)1, 2, 3, 9 Renner C.... Pfreundschuh M. (J. Immunol. 1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Characterization of functional domains of human EB1 family proteins. (PubMed id 14514668)1, 2 Bu W. and Su L.-K. (J. Biol. Chem. 2003)
    8. EB1 targets to kinetochores with attached, polymerizing microtubules. (PubMed id 12475954)1, 3 Tirnauer J.S....Mitchison T.J. (Mol. Biol. Cell 2002)
    9. EB/RP gene family encodes tubulin binding proteins. (PubMed id 10188731)1, 2 Juwana J.-P.... Renner C. (Int. J. Cancer 1999)
    10. Interactions between EB1 and microtubules: dramatic effect of affinity tags and evidence for cooperative behavior. (PubMed id 19778897)1, 9 Zhu Z.C....Goodson H.V. (J. Biol. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 10982 HGNC: 6891 AceView: MAPRE2 Ensembl:ENSG00000166974 euGenes: HUgn10982
    ECgene: MAPRE2 H-InvDB: MAPRE2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAPRE2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPRE2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MAPRE2 gene:
    Search GeneIP for patents involving MAPRE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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