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Aliases for MAPRE2 Gene

Aliases for MAPRE2 Gene

  • Microtubule Associated Protein RP/EB Family Member 2 2 3 5
  • APC-Binding Protein EB1 2 3
  • APC-Binding Protein EB2 3 4
  • End-Binding Protein 2 3 4
  • EB2 3 4
  • RP1 3 4
  • Microtubule-Associated Protein, RP/EB Family, Member 2 3
  • T-Cell Activation Protein, EB1 Family 3
  • CSCSC2 3
  • EB1 3

External Ids for MAPRE2 Gene

Previous GeneCards Identifiers for MAPRE2 Gene

  • GC18P032655
  • GC18P032440
  • GC18P030873
  • GC18P030875
  • GC18P029416
  • GC18P032556

Summaries for MAPRE2 Gene

Entrez Gene Summary for MAPRE2 Gene

  • The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for MAPRE2 Gene

MAPRE2 (Microtubule Associated Protein RP/EB Family Member 2) is a Protein Coding gene. Diseases associated with MAPRE2 include multiple benign circumferential skin creases on limbs and adenomatous polyposis coli. Among its related pathways are PAK Pathway and Remodeling of Adherens Junctions. GO annotations related to this gene include microtubule binding. An important paralog of this gene is MAPRE3.

UniProtKB/Swiss-Prot for MAPRE2 Gene

  • May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).

Gene Wiki entry for MAPRE2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPRE2 Gene

Genomics for MAPRE2 Gene

Regulatory Elements for MAPRE2 Gene

Promoters for MAPRE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAPRE2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAPRE2 Gene

Chromosome:
18
Start:
34,976,928 bp from pter
End:
35,143,470 bp from pter
Size:
166,543 bases
Orientation:
Plus strand

Genomic View for MAPRE2 Gene

Genes around MAPRE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPRE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPRE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPRE2 Gene

Proteins for MAPRE2 Gene

  • Protein details for MAPRE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15555-MARE2_HUMAN
    Recommended name:
    Microtubule-associated protein RP/EB family member 2
    Protein Accession:
    Q15555
    Secondary Accessions:
    • B2RE21
    • B3KR39
    • B4DJV4
    • B7Z2L3
    • E9PHR3
    • F5H1V8
    • G5E9I6
    • Q9UQ33

    Protein attributes for MAPRE2 Gene

    Size:
    327 amino acids
    Molecular mass:
    37031 Da
    Quaternary structure:
    • Interacts with DCTN1. Binds to the C-terminal domain of APC. Binds monomeric and polymerized tubulin.
    SequenceCaution:
    • Sequence=BAA83375.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MAPRE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPRE2 Gene

Proteomics data for MAPRE2 Gene at MOPED

Post-translational modifications for MAPRE2 Gene

  • Ubiquitination at Lys 156 and Lys 165
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for MAPRE2 Gene

Domains & Families for MAPRE2 Gene

Protein Domains for MAPRE2 Gene

Suggested Antigen Peptide Sequences for MAPRE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15555

UniProtKB/Swiss-Prot:

MARE2_HUMAN :
  • Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.
  • Belongs to the MAPRE family.
Domain:
  • Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 EB1 C-terminal domain.
Family:
  • Belongs to the MAPRE family.
genes like me logo Genes that share domains with MAPRE2: view

No data available for Gene Families for MAPRE2 Gene

Function for MAPRE2 Gene

Molecular function for MAPRE2 Gene

GENATLAS Biochemistry:
microtubule-associated protein,RP/EB family,member 2,highly homolog to MAPRE1,APC binding gene family,differentially expressed in activated T cells,putatively belonging to the immediate/early gene family,which controls the signal transduction cascade downstream of the TCR,may be involved in the tumorigenesis of colorectal cancers but may also play a role in the proliferative control of normal cells
UniProtKB/Swiss-Prot Function:
May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).
genes like me logo Genes that share phenotypes with MAPRE2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MAPRE2

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAPRE2 Gene

Localization for MAPRE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPRE2 Gene

Cytoplasm, cytoskeleton. Note=Associated with the microtubule network. Accumulates at the plus end of microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPRE2 Gene COMPARTMENTS Subcellular localization image for MAPRE2 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAPRE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035371 microtubule plus-end IEA --
genes like me logo Genes that share ontologies with MAPRE2: view

Pathways & Interactions for MAPRE2 Gene

genes like me logo Genes that share pathways with MAPRE2: view

Pathways by source for MAPRE2 Gene

Gene Ontology (GO) - Biological Process for MAPRE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0008283 cell proliferation TAS 9233623
genes like me logo Genes that share ontologies with MAPRE2: view

No data available for SIGNOR curated interactions for MAPRE2 Gene

Drugs & Compounds for MAPRE2 Gene

No Compound Related Data Available

Transcripts for MAPRE2 Gene

Unigene Clusters for MAPRE2 Gene

Microtubule-associated protein, RP/EB family, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPRE2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2: - -
SP3:

Relevant External Links for MAPRE2 Gene

GeneLoc Exon Structure for
MAPRE2
ECgene alternative splicing isoforms for
MAPRE2

Expression for MAPRE2 Gene

mRNA expression in normal human tissues for MAPRE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAPRE2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.0), Platelet (11.5), and Frontal cortex (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPRE2 Gene



SOURCE GeneReport for Unigene cluster for MAPRE2 Gene Hs.532824

mRNA Expression by UniProt/SwissProt for MAPRE2 Gene

Q15555-MARE2_HUMAN
Tissue specificity: Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes.
genes like me logo Genes that share expression patterns with MAPRE2: view

Protein tissue co-expression partners for MAPRE2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MAPRE2 Gene

Orthologs for MAPRE2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPRE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPRE2 35
  • 99.59 (n)
  • 99.69 (a)
MAPRE2 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAPRE2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPRE2 36
  • 86 (a)
OneToOne
MAPRE2 35
  • 93.25 (n)
  • 97.47 (a)
mouse
(Mus musculus)
Mammalia Mapre2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAPRE2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPRE2 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAPRE2 36
  • 88 (a)
OneToOne
MAPRE2 35
  • 86.31 (n)
  • 93.1 (a)
lizard
(Anolis carolinensis)
Reptilia MAPRE2 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mapre2-A 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.999 35
zebrafish
(Danio rerio)
Actinopterygii MAPRE2 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG18190 37
  • 35 (a)
Eb1 37
  • 47 (a)
Eb1 36
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea VW02B12L.3 37
  • 34 (a)
Y59A8B.7 37
  • 46 (a)
ebp-1 36
  • 36 (a)
ManyToMany
ebp-3 36
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BIM1 36
  • 25 (a)
OneToMany
Species with no ortholog for MAPRE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MAPRE2 Gene

ENSEMBL:
Gene Tree for MAPRE2 (if available)
TreeFam:
Gene Tree for MAPRE2 (if available)

Paralogs for MAPRE2 Gene

Paralogs for MAPRE2 Gene

(2) SIMAP similar genes for MAPRE2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MAPRE2: view

Variants for MAPRE2 Gene

Sequence variations from dbSNP and Humsavar for MAPRE2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs11538993 - 35,102,034(+) TAACT(A/G)CGATG nc-transcript-variant, reference, missense
rs965 -- 35,047,524(-) AATTG(C/T)AGGTT intron-variant
rs992 -- 35,047,521(-) TGCAG(C/G/T)TTTCC intron-variant
rs273356 -- 35,017,498(-) aggag(A/T)actac intron-variant
rs273357 -- 35,017,273(-) caaag(A/C)aatcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPRE2 Gene

Variant ID Type Subtype PubMed ID
dgv3406n71 CNV Loss 21882294
nsv516682 CNV Loss 19592680
nsv132225 CNV Loss 16902084
esv2458354 CNV Deletion 19546169
esv2362277 CNV Deletion 18987734
esv2716954 CNV Deletion 23290073
esv7024 CNV Loss 19470904
esv2676768 CNV Deletion 23128226

Variation tolerance for MAPRE2 Gene

Residual Variation Intolerance Score: 46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPRE2 Gene

HapMap Linkage Disequilibrium report
MAPRE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPRE2 Gene

Disorders for MAPRE2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAPRE2 Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
multiple benign circumferential skin creases on limbs
  • michelin tire baby syndrome
adenomatous polyposis coli
  • brain tumor-polyposis syndrome 2
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAPRE2

Genetic Association Database (GAD)
MAPRE2
Human Genome Epidemiology (HuGE) Navigator
MAPRE2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPRE2
genes like me logo Genes that share disorders with MAPRE2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPRE2 Gene

Publications for MAPRE2 Gene

  1. RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells. (PMID: 9233623) Renner C. … Pfreundschuh M. (J. Immunol. 1997) 2 3 4 23 67
  2. Molecular insights into mammalian end-binding protein heterodimerization. (PMID: 20008324) De Groot C.O. … Steinmetz M.O. (J. Biol. Chem. 2010) 3 23
  3. Interactions between EB1 and microtubules: dramatic effect of affinity tags and evidence for cooperative behavior. (PMID: 19778897) Zhu Z.C. … Goodson H.V. (J. Biol. Chem. 2009) 3 23
  4. Structural basis of microtubule plus end tracking by XMAP215, CLIP- 170, and EB1. (PMID: 17889670) Slep K.C. … Vale R.D. (Mol. Cell 2007) 3 23
  5. Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells. (PMID: 16763565) Draviam V.M. … Sorger P.K. (EMBO J. 2006) 3 23

Products for MAPRE2 Gene

Sources for MAPRE2 Gene

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