Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MAPRE2 Gene

Aliases for MAPRE2 Gene

  • Microtubule-Associated Protein, RP/EB Family, Member 2 2 3
  • EB2 3 4 6
  • RP1 3 4 6
  • APC-Binding Protein EB1 2 3
  • APC-Binding Protein EB2 3 4
  • End-Binding Protein 2 3 4
  • Microtubule-Associated Protein RP/EB Family Member 2 3
  • T-Cell Activation Protein, EB1 Family 3
  • EB1 3

External Ids for MAPRE2 Gene

Previous GeneCards Identifiers for MAPRE2 Gene

  • GC18P032655
  • GC18P032440
  • GC18P030873
  • GC18P030875
  • GC18P029416
  • GC18P032556

Summaries for MAPRE2 Gene

Entrez Gene Summary for MAPRE2 Gene

  • The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for MAPRE2 Gene

MAPRE2 (Microtubule-Associated Protein, RP/EB Family, Member 2) is a Protein Coding gene. Diseases associated with MAPRE2 include adenomatous polyposis coli. Among its related pathways are PAK Pathway and Remodeling of Adherens Junctions. GO annotations related to this gene include microtubule binding. An important paralog of this gene is MAPRE3.

UniProtKB/Swiss-Prot for MAPRE2 Gene

  • May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).

Gene Wiki entry for MAPRE2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPRE2 Gene

Genomics for MAPRE2 Gene

Regulatory Elements for MAPRE2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAPRE2 Gene

Start:
34,976,928 bp from pter
End:
35,143,470 bp from pter
Size:
166,543 bases
Orientation:
Plus strand

Genomic View for MAPRE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAPRE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPRE2 Gene

Proteins for MAPRE2 Gene

  • Protein details for MAPRE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15555-MARE2_HUMAN
    Recommended name:
    Microtubule-associated protein RP/EB family member 2
    Protein Accession:
    Q15555
    Secondary Accessions:
    • B2RE21
    • B3KR39
    • B4DJV4
    • B7Z2L3
    • E9PHR3
    • F5H1V8
    • G5E9I6
    • Q9UQ33

    Protein attributes for MAPRE2 Gene

    Size:
    327 amino acids
    Molecular mass:
    37031 Da
    Quaternary structure:
    • Interacts with DCTN1. Binds to the C-terminal domain of APC. Binds monomeric and polymerized tubulin.
    SequenceCaution:
    • Sequence=BAA83375.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MAPRE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPRE2 Gene

Proteomics data for MAPRE2 Gene at MOPED

Post-translational modifications for MAPRE2 Gene

  • Ubiquitination at Lys156, Lys165, and Lys271
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MAPRE2 Gene

Domains for MAPRE2 Gene

Protein Domains for MAPRE2 Gene

Suggested Antigen Peptide Sequences for MAPRE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15555

UniProtKB/Swiss-Prot:

MARE2_HUMAN :
  • Q15555
Domain:
  • Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 EB1 C-terminal domain.
Family:
  • Belongs to the MAPRE family.
genes like me logo Genes that share domains with MAPRE2: view

No data available for Gene Families for MAPRE2 Gene

Function for MAPRE2 Gene

Molecular function for MAPRE2 Gene

GENATLAS Biochemistry: microtubule-associated protein,RP/EB family,member 2,highly homolog to MAPRE1,APC binding gene family,differentially expressed in activated T cells,putatively belonging to the immediate/early gene family,which controls the signal transduction cascade downstream of the TCR,may be involved in the tumorigenesis of colorectal cancers but may also play a role in the proliferative control of normal cells
UniProtKB/Swiss-Prot Function: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).

Gene Ontology (GO) - Molecular Function for MAPRE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with MAPRE2: view

Phenotypes for MAPRE2 Gene

GenomeRNAi human phenotypes for MAPRE2:
genes like me logo Genes that share phenotypes with MAPRE2: view

Animal Model Products

CRISPR Products

miRNA for MAPRE2 Gene

miRTarBase miRNAs that target MAPRE2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAPRE2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAPRE2 Gene

Localization for MAPRE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPRE2 Gene

Cytoplasm, cytoskeleton. Note=Associated with the microtubule network. Accumulates at the plus end of microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPRE2 Gene COMPARTMENTS Subcellular localization image for MAPRE2 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAPRE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16791210
GO:0015630 microtubule cytoskeleton IDA --
GO:0035371 microtubule plus-end IEA --
genes like me logo Genes that share ontologies with MAPRE2: view

Pathways for MAPRE2 Gene

genes like me logo Genes that share pathways with MAPRE2: view

Pathways by source for MAPRE2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MAPRE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0007165 signal transduction TAS 9233623
GO:0008283 cell proliferation TAS 9233623
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with MAPRE2: view

Transcripts for MAPRE2 Gene

Unigene Clusters for MAPRE2 Gene

Microtubule-associated protein, RP/EB family, member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAPRE2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPRE2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2: - -
SP3:

Relevant External Links for MAPRE2 Gene

GeneLoc Exon Structure for
MAPRE2
ECgene alternative splicing isoforms for
MAPRE2

Expression for MAPRE2 Gene

mRNA expression in normal human tissues for MAPRE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPRE2 Gene

SOURCE GeneReport for Unigene cluster for MAPRE2 Gene Hs.532824

mRNA Expression by UniProt/SwissProt for MAPRE2 Gene

Q15555-MARE2_HUMAN
Tissue specificity: Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes.
genes like me logo Genes that share expressions with MAPRE2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MAPRE2 Gene

Orthologs for MAPRE2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPRE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPRE2 35
  • 99.59 (n)
  • 99.69 (a)
MAPRE2 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAPRE2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPRE2 35
  • 93.25 (n)
  • 97.47 (a)
MAPRE2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapre2 16
Mapre2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAPRE2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPRE2 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAPRE2 35
  • 86.31 (n)
  • 93.1 (a)
MAPRE2 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPRE2 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mapre2-A 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.999 35
zebrafish
(Danio rerio)
Actinopterygii MAPRE2 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Eb1 36
  • 46 (a)
OneToMany
CG18190 37
  • 35 (a)
Eb1 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea ebp-1 36
  • 36 (a)
ManyToMany
ebp-3 36
  • 22 (a)
ManyToMany
VW02B12L.3 37
  • 34 (a)
Y59A8B.7 37
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BIM1 36
  • 25 (a)
OneToMany
Species with no ortholog for MAPRE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MAPRE2 Gene

ENSEMBL:
Gene Tree for MAPRE2 (if available)
TreeFam:
Gene Tree for MAPRE2 (if available)

Paralogs for MAPRE2 Gene

Paralogs for MAPRE2 Gene

Selected SIMAP similar genes for MAPRE2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MAPRE2: view

Variants for MAPRE2 Gene

Sequence variations from dbSNP and Humsavar for MAPRE2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs965 -- 35,047,524(-) AATTG(C/T)AGGTT intron-variant
rs992 -- 35,047,521(-) TGCAG(C/G/T)TTTCC intron-variant
rs12922 -- 35,142,953(+) TTAGT(A/C)CCCCC utr-variant-3-prime, nc-transcript-variant
rs13512 -- 35,142,190(+) TATAC(A/C)CAGCA utr-variant-3-prime, nc-transcript-variant
rs14936 -- 35,141,703(-) CCAGG(A/T)AGGGA utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPRE2 Gene

Variant ID Type Subtype PubMed ID
dgv3406n71 CNV Loss 21882294
nsv516682 CNV Loss 19592680
nsv132225 CNV Loss 16902084
esv2458354 CNV Deletion 19546169
esv2362277 CNV Deletion 18987734
esv2716954 CNV Deletion 23290073
esv7024 CNV Loss 19470904
esv2676768 CNV Deletion 23128226

Relevant External Links for MAPRE2 Gene

HapMap Linkage Disequilibrium report
MAPRE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPRE2 Gene

Disorders for MAPRE2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MAPRE2 Gene including...

Search for MAPRE2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for MAPRE2 Gene

(4) Novoseek inferred disease relationships for MAPRE2 Gene

Disease -log(P) Hits PubMed IDs
familial adenomatous polyposis 67.3 4
ebv infections 35.6 1
colorectal cancer 12.8 2
herpes simplex 11.3 2

Relevant External Links for MAPRE2

Genetic Association Database (GAD)
MAPRE2
Human Genome Epidemiology (HuGE) Navigator
MAPRE2
genes like me logo Genes that share disorders with MAPRE2: view

No data available for UniProtKB/Swiss-Prot for MAPRE2 Gene

Publications for MAPRE2 Gene

  1. RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells. (PMID: 9233623) Renner C. … Pfreundschuh M. (J. Immunol. 1997) 2 3 4 23
  2. Characterization of human MAPRE genes and their proteins. (PMID: 11161807) Su L.-K. … Qi Y. (Genomics 2001) 3 23
  3. Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization. (PMID: 11470413) Nakamura M. … Lu K.P. (Curr. Biol. 2001) 3 23
  4. Chromosomal localization and promoter analysis of the adenomatous polyposis coli binding protein RP1. (PMID: 11593399) Wadle A. … Renner C. (Oncogene 2001) 3 23
  5. Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells. (PMID: 16763565) Draviam V.M. … Sorger P.K. (EMBO J. 2006) 3 23

Products for MAPRE2 Gene

Sources for MAPRE2 Gene

Back to Top

Content