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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPRE2 Gene

protein-coding   GIFtS: 63
GCID: GC18P032556

microtubule-associated protein, RP/EB family, member 2
 Explore 14 diseases affiliated with
MAPRE2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAPRE2    

Aliases
for MAPRE2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Microtubule-Associated Protein, RP/EB Family, Member 21 2     APC-Binding Protein EB22 3
EB21 2 3 5     APC-Binding Protein EB12
RP11 2 3 5     Microtubule-Associated Protein RP/EB Family Member 22
EB11 2     T-Cell Activation Protein, EB1 Family2
End-Binding Protein 22 3     

External Ids:    HGNC: 68911   Entrez Gene: 109822   Ensembl: ENSG000001669747   OMIM: 6057895   UniProtKB: Q155553   

Export aliases for MAPRE2 gene to outside databases

Previous GC identifers: GC18P032655 GC18P032440 GC18P030873 GC18P030875 GC18P029416


Summaries
for MAPRE2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAPRE2:
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding
EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during
mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of
normal cells. Alternative splicing of this gene results in multiple transcript variants. (provided by RefSeq, Jan
2012)

UniProtKB/Swiss-Prot: MARE2_HUMAN, Q15555
Function: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring
them at centrosomes. May play a role in cell migration (By similarity)

Gene Wiki entry for MAPRE2


Genomic Views
for MAPRE2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010966.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPRE2 gene promoter:
         HEN1   AREB6   NF-1   Chx10   CUTL1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): MAPRE2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAPRE2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPRE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.1   Ensembl cytogenetic band:  18q12.1   HGNC cytogenetic band: 18q12.1

MAPRE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPRE2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P032556:  view genomic region     (about GC identifiers)

Start:
 32,556,892 bp from pter      End:
 32,723,434 bp from pter
Size:
 166,543 bases      Orientation:
 plus strand

Proteins
for MAPRE2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MARE2_HUMAN, Q15555 (See protein sequence)
Recommended Name: Microtubule-associated protein RP/EB family member 2  
Size: 327 amino acids; 37031 Da
Subunit: Interacts with DCTN1. Binds to the C-terminal domain of APC. Binds monomeric and polymerized tubulin
Subcellular location: Cytoplasm, cytoskeleton. Note=Associated with the microtubule network. Accumulates at the plus
end of microtubules
Sequence caution: Sequence=BAA83375.1; Type=Erroneous initiation;
Secondary accessions: B2RE21 B3KR39 B7Z2L3 E9PHR3 F5H1V8 Q9UQ33
Alternative splicing: 4 isoforms:  Q15555-1   Q15555-2   Q15555-3   Q15555-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAPRE2: NX_Q15555

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15555

    • MAPRE2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001137298.1  NP_001137299.1  NP_001243349.1  NP_055083.1  

    ENSEMBL proteins: 
     ENSP00000468216   ENSP00000465939   ENSP00000466871   ENSP00000407723   ENSP00000300249  
     ENSP00000446343   ENSP00000468588   ENSP00000464921   ENSP00000396074  

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    OriGene Purified Protein: MAPRE2
    OriGene Protein Over-expression Lysate (see all 3): MAPRE2
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    Novus Biologicals MAPRE2 Proteins
    Novus Biologicals MAPRE2 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for MAPRE2
    Uscn Proteins for MAPRE2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule IEA--
    GO:0015630microtubule cytoskeleton IDA--


    MAPRE2 for ontologies           About GeneDecksing



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    Uscn Antibodies for MAPRE2
    ThermoFisher Antibodies for MAPRE2

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    Uscn ELISAs and CLIAs for MAPRE2

    Protein Domains /
    Families
    for MAPRE2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAPRE2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001715 CH-domain
     IPR004953 EB1_C

    Graphical View of Domain Structure for InterPro Entry Q15555

    ProtoNet protein and cluster: Q15555

    2 Blocks protein families:
    IPB001715 Calponin-like actin-binding
    IPB004953 EB1 protein


    UniProtKB/Swiss-Prot: MARE2_HUMAN, Q15555
    Domain: Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in
    microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1
    Similarity: Belongs to the MAPRE family
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 EB1 C-terminal domain


    Function
    for MAPRE2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MARE2_HUMAN, Q15555
    Function: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring
    them at centrosomes. May play a role in cell migration (By similarity)

         Genatlas biochemistry entry for MAPRE2:
    microtubule-associated protein,RP/EB family,member 2,highly homolog to MAPRE1,APC binding gene family,differentially
    expressed in activated T cells,putatively belonging to the immediate/early gene family,which controls the signal
    transduction cascade downstream of the TCR,may be involved in the tumorigenesis of colorectal cancers but may also
    play a role in the proliferative control of normal cells

    miRNA
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    hsa-mir-204 (MIRT005836)

    OriGene 3'-UTR Clone (see all 3): MAPRE2
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPRE2
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    hsa-miR-300 hsa-miR-128 hsa-miR-200a hsa-miR-29a hsa-miR-1260b hsa-miR-578 hsa-miR-3074-3p hsa-miR-766
    SwitchGear 3'UTR luciferase reporter plasmid: MAPRE2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPRE2 (see all 7)
    OriGene shRNA RFP: MAPRE2
    OriGene siRNA: MAPRE2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPRE2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAPRE2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPRE2 (see all 7)
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    GenScript: all cDNA clones in your preferred vector (see all 3): MAPRE2 (NM_001143827)
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    Cell Line
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    Search LifeMap BioReagents cell lines for MAPRE2

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPRE2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008017microtubule binding IEA--


    MAPRE2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MAPRE2:
     Decreased circadian period len 


    Pathways & Interactions
    for MAPRE2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Remodeling of Adherens Junctions
    		Remodeling of Adherens Junctions1.00
    2PAK Pathway
    		Epithelial Adherens Junctions0.36

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPRE2
        Remodeling of Adherens Junctions
    Epithelial Adherens Junctions


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPRE2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for MAPRE2 (Q155552, 3 ENSP000003002494) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LMO2P257912, 3, ENSP000002578184MINT-66036 I2D: score=5 STRING: ENSP00000257818
    MAPRE3Q9UPY82, 3, ENSP000002331214MINT-67922 I2D: score=5 STRING: ENSP00000233121
    NIF3L1Q9GZT82, 3, ENSP000003863944MINT-67424 I2D: score=5 STRING: ENSP00000386394
    APCP250543, ENSP000002574304I2D: score=1 STRING: ENSP00000257430
    CLIP1P306223, ENSP000003516654I2D: score=1 STRING: ENSP00000351665
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis IEA--
    GO:0007165signal transduction TAS9233623
    GO:0008283cell proliferation TAS9233623
    GO:0051301cell division IEA--


    MAPRE2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAPRE2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAPRE2
    Search CenterWatch for drugs/clinical trials and news about MAPRE2 / MARE2 

    Transcripts
    for MAPRE2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAPRE2 gene (4 alternative transcripts): 
    NM_001143826.2  NM_001143827.2  NM_001256420.1  NM_014268.3  

    Unigene Cluster for MAPRE2:

    Microtubule-associated protein, RP/EB family, member 2
    Hs.532824  [show with all ESTs]
    Unigene Representative Sequence: NM_001143827
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000591734 ENST00000589180 ENST00000590793 ENST00000587359 ENST00000436190(uc010xcc.2)
    ENST00000300249(uc002kyf.2 uc002kyg.3 uc002kyh.3 uc010xcd.2)
    ENST00000538170 ENST00000588910 ENST00000585592 ENST00000589699 ENST00000588349
    ENST00000588085 ENST00000413393(uc010xcb.2)

    miRNA
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    hsa-miR-300 hsa-miR-128 hsa-miR-200a hsa-miR-29a hsa-miR-1260b hsa-miR-578 hsa-miR-3074-3p hsa-miR-766
    SwitchGear 3'UTR luciferase reporter plasmid: MAPRE2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPRE2 (see all 7)
    OriGene shRNA RFP: MAPRE2
    OriGene siRNA: MAPRE2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPRE2
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): MAPRE2 (NM_001143827)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPRE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPRE2 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAPRE2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPRE2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPRE2

    Additional cDNA sequence: 

    AB016823.1 AK090945.1 AK294833.1 AK296251.1 AK315766.1 BC007318.2 BT020086.1 CR536545.1 
    NR_046177.1 U90437.1 X94232.1 

    16 DOTS entries:

    DT.449645  DT.100658664  DT.91935975  DT.100658659  DT.101965704  DT.100849633  DT.95256923  DT.101980771 
    DT.121097184  DT.121097218  DT.100641597  DT.95256927  DT.100644918  DT.91864725  DT.95256928  DT.75175813 

    24/335 AceView cDNA sequences (see all 335):

    BM989577 AW513644 BP365371 BC007318 AL134382 AL536492 AX746696 AK090945 
    AA912397 AA765615 BP344065 AA234084 AA232674 AI218281 CR536545 AV709636 
    BX493438 BM765983 CA426135 AI581022 AL038940 CR597075 AI866641 BM462012 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MAPRE2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
    SP1:                                            -               
    SP2:                    -                       -               
    SP3:                                                            


    ECgene alternative splicing isoforms for MAPRE2

    Expression
    for MAPRE2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPRE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAATTCATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAPRE2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobulePeriportal HepatocytesLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MAPRE2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPRE2

    SOURCE GeneReport for Unigene cluster: Hs.532824

    UniProtKB/Swiss-Prot: MARE2_HUMAN, Q15555
    Tissue specificity: Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAPRE2: 
              Cytoskeleton Regulators in human mouse rat
              Adherens Junctions in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPRE2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPRE2

    Orthologs
    for MAPRE2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAPRE2 gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAPRE21 microtubule-associated protein, RP/EB family, member more 86.31(n)
    93.1(a)    		   421105  NM_001031017.1  NP_001026188.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MAPRE26
    		 --
    		 93(a)
    		 1 ↔ 1
    		 GL343207.1(1974442-2017298)
    African clawed frog
    (Xenopus laevis)    		 Amphibia mapre2-A2 microtubule-associated protein, RP/EB family, member more 83.48(n)    BC044671.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1717881 zgc:171788 73.06(n)
    80.5(a)    		   557679  NM_001109702.1  NP_001103172.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Eb13 microtubule-based process microtubule
    binding    		 47(a)
    (best of 2)    		   42C7   --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y59A8B.73   -- 46(a)
    (best of 2)    		   V(18046176-18054907)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATEB1B6
    ATEB1A6
    (see all 3)    		 microtubule end binding protein EB1A
    (see all 3)    		 30(a)
    30(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 5(25092641-25095244)
    3(17581096-17583586)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 ATEB1A-like microtubule associated protein, putati...
    ATEB1A-like microtubule associated protein, putati...
    		 32(a)
    25(a)
    		 many ↔ many
    many ↔ many
    		 4(32499434-32502511)
    10(18962442-18964878)


    ENSEMBL Gene Tree for MAPRE2 (if available)
    TreeFam Gene Tree for MAPRE2 (if available) 

    Paralogs
    for MAPRE2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPRE2 gene
    MAPRE32  MAPRE12  
    2 SIMAP similar genes for MAPRE2 using alignment to 6 protein entries:     MARE2_HUMAN (see all proteins):
    MAPRE3    MAPRE1

    MAPRE2 for paralogs           About GeneDecksing



    Genomic Variants
    for MAPRE2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2676 NCBI SNPs in MAPRE2 are shown (see all 2676)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1910836641,2
    		--32554899(+) TCTTTC/TGGGTA 1 -- us2k10--------
    rs1175633961,2
    		F,--32555044(+) GGTACG/AGATTC 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs4897441,2
    		C,F,O,A,H,--32555153(+) GGAAAT/CACTCA 1 -- us2k118Minor allele frequency- C:0.38MN NS EA NA WA 1392
    rs1822672171,2
    		--32555174(+) ACAGAC/GAGAGA 1 -- us2k10--------
    rs1849380791,2
    		--32555258(+) ATCTTC/TATTAA 1 -- us2k10--------
    rs1167075581,2
    		F,--32555318(+) TGTACT/CAAACC 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1431717251,2
    		--32555385(+) CTGGAC/TATTAT 1 -- us2k10--------
    rs1909255021,2
    		--32555388(+) GACATC/TATCTG 1 -- us2k10--------
    rs1389448151,2
    		--32555414(+) TGATTC/TTTTAA 1 -- us2k10--------
    rs1830701771,2
    		--32555424(+) ATTCAA/GTGTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAPRE2 (32556892 - 32723434 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for MAPRE2
         2 CNVs: 49975 102633
         2 Indels: 45643 61610

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    Disorders / Diseases
    for MAPRE2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAPRE2 for disorders           About GeneDecksing

    OMIM gene information: 605789    OMIM disorders: --

    14 diseases for MAPRE2:    About MalaCards
    adenomatous polyposis coli    polyposis    colorectal cancer    familial adenomatous polyposis
    esophageal squamous cell carcinoma    squamous cell carcinoma    burkitt's lymphoma    eye disease
    esophagitis    pancreatic cancer    breast cancer    pancreatitis
    carcinoma    malaria

    1 disease from the University of Copenhagen DISEASES database for MAPRE2:
    Burkitt's lymphoma

    4 Novoseek disease relationships for MAPRE2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    familial adenomatous polyposis 67.3 4 11470413 (1), 11857735 (1), 9233623 (1), 16763565 (1)
    ebv infections 35.6 1 10725330 (1)
    colorectal cancer 12.8 2 9233623 (1), 11593399 (1)
    herpes simplex 11.3 3 16500893 (1), 12208942 (1)

    Genetic Association Database (GAD): MAPRE2
    Human Genome Epidemiology (HuGE) Navigator: MAPRE2 (1 document)

    Export disorders for MAPRE2 gene to outside databases

    Publications
    for MAPRE2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPRE2 gene, integrated from 9 sources (see all 86):
    (articles sorted by number of sources associating them with MAPRE2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells. (PubMed id 9233623)1, 2, 3, 9 Renner C.... Pfreundschuh M. (1997)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Characterization of functional domains of human EB1 family proteins. (PubMed id 14514668)1, 2 Bu W. and Su L.-K. (2003)
    7. EB1 targets to kinetochores with attached, polymerizi ng microtubules. (PubMed id 12475954)1, 3 Tirnauer J.S....Mitchison T.J. (2002)
    8. EB/RP gene family encodes tubulin binding proteins. (PubMed id 10188731)1, 2 Juwana J.-P.... Renner C. (1999)
    9. Interactions between EB1 and microtubules: dramatic e ffect of affinity tags and evidence for cooperative behavior. (PubMed id 19778897)1, 9 Zhu Z.C....Goodson H.V. (2009)
    10. Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization. (PubMed id 11470413)1, 9 Nakamura M....Lu K.P. (2001)

    External Searches for MAPRE2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing MAPRE2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10982 HGNC: 6891 AceView: MAPRE2 Ensembl:ENSG00000166974 euGenes: HUgn10982
    ECgene: MAPRE2 H-InvDB: MAPRE2

    Other Databases showing MAPRE2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAPRE2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPRE2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPRE2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MAPRE2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAPRE2 gene:
    Search GeneIP for patents involving MAPRE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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