Aliases for MAPRE1 Gene
External Ids for MAPRE1 Gene
Previous GeneCards Identifiers for MAPRE1 Gene
The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAPRE1 Gene
MAPRE1 (Microtubule Associated Protein RP/EB Family Member 1) is a Protein Coding gene. Diseases associated with MAPRE1 include Adenomatous Polyposis Coli and Colorectal Cancer. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Remodeling of Adherens Junctions. GO annotations related to this gene include poly(A) RNA binding and protein C-terminus binding. An important paralog of this gene is MAPRE3.
UniProtKB/Swiss-Prot for MAPRE1 Gene
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.