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Aliases for MAPRE1 Gene

Aliases for MAPRE1 Gene

  • Microtubule-Associated Protein, RP/EB Family, Member 1 2 3
  • EB1 3 4 6
  • Adenomatous Polyposis Coli-Binding Protein EB1 2 3
  • APC-Binding Protein EB1 3 4
  • End-Binding Protein 1 3 4
  • Microtubule-Associated Protein RP/EB Family Member 1 3

External Ids for MAPRE1 Gene

Previous GeneCards Identifiers for MAPRE1 Gene

  • GC20P031166
  • GC20P032076
  • GC20P032123
  • GC20P030871
  • GC20P031407
  • GC20P028194

Summaries for MAPRE1 Gene

Entrez Gene Summary for MAPRE1 Gene

  • The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPRE1 Gene

MAPRE1 (Microtubule-Associated Protein, RP/EB Family, Member 1) is a Protein Coding gene. Diseases associated with MAPRE1 include pediatric ependymoma and adenomatous polyposis coli. Among its related pathways are PAK Pathway and Cell Cycle, Mitotic. GO annotations related to this gene include protein C-terminus binding and microtubule plus-end binding. An important paralog of this gene is MAPRE2.

UniProtKB/Swiss-Prot for MAPRE1 Gene

  • Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.

Gene Wiki entry for MAPRE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPRE1 Gene

Genomics for MAPRE1 Gene

Regulatory Elements for MAPRE1 Gene

Genomic Location for MAPRE1 Gene

Start:
32,819,893 bp from pter
End:
32,850,405 bp from pter
Size:
30,513 bases
Orientation:
Plus strand

Genomic View for MAPRE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAPRE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPRE1 Gene

Proteins for MAPRE1 Gene

  • Protein details for MAPRE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15691-MARE1_HUMAN
    Recommended name:
    Microtubule-associated protein RP/EB family member 1
    Protein Accession:
    Q15691
    Secondary Accessions:
    • B2R6I7
    • E1P5M8
    • Q3KQS8

    Protein attributes for MAPRE1 Gene

    Size:
    268 amino acids
    Molecular mass:
    29999 Da
    Quaternary structure:
    • Homodimer. Heterodimer with MAPRE3. Interacts with DCTN1, DCTN2, DIAPH1, DIAPH2, TERF1 and dynein intermediate chain. Interacts with APC (via C-terminal domain), CLASP2, DST, KIF2C and STIM1; probably required for their targeting to the growing microtubule plus ends. Interacts with MTUS2; interaction is direct and probably targets MTUS2 to microtubules. Interacts with APC2. Interacts with CLASP1. Interacts with CDK5RAP2. Interacts with MACF1 (By similarity). Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity). Interacts with KCNAB2 (By similarity). Interacts (via C-terminus) with CLIP1. Interacts with SLAIN2. Interacts with KIF18B; this interaction is required for efficient accumulation of KIF18B at microtubule plus ends. Interacts with MISP. Interacts with KNSTRN.

    Three dimensional structures from OCA and Proteopedia for MAPRE1 Gene

neXtProt entry for MAPRE1 Gene

Proteomics data for MAPRE1 Gene at MOPED

Post-translational modifications for MAPRE1 Gene

  • Ubiquitination at Lys66, Lys76, Lys83, Lys100, Lys113, Lys151, Lys174, Lys182, Lys212, and Lys220
  • Modification sites at PhosphoSitePlus

Other Protein References for MAPRE1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAPRE1 (EB1)

No data available for DME Specific Peptides for MAPRE1 Gene

Domains for MAPRE1 Gene

Protein Domains for MAPRE1 Gene

Suggested Antigen Peptide Sequences for MAPRE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15691

UniProtKB/Swiss-Prot:

MARE1_HUMAN :
  • Q15691
Domain:
  • Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 EB1 C-terminal domain.
Family:
  • Belongs to the MAPRE family.
genes like me logo Genes that share domains with MAPRE1: view

No data available for Gene Families for MAPRE1 Gene

Function for MAPRE1 Gene

Molecular function for MAPRE1 Gene

GENATLAS Biochemistry: Microtubule-associated protein, RP/EB family, member 1,component of the microtubule cytoskeleton,colocalyzing both to cytoplasmic microtubules in interphase cells and to spindle microtubules during mitosis,associating with the C terminal region of APC
UniProtKB/Swiss-Prot Function: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.

Gene Ontology (GO) - Molecular Function for MAPRE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10226031
GO:0008017 microtubule binding --
GO:0008022 protein C-terminus binding TAS 7606712
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0051010 microtubule plus-end binding IDA 15631994
genes like me logo Genes that share ontologies with MAPRE1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAPRE1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAPRE1 Gene

Localization for MAPRE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPRE1 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with the microtubule network at the growing distal tip of microtubules. Also enriched at the centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPRE1 Gene COMPARTMENTS Subcellular localization image for MAPRE1 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
golgi apparatus 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MAPRE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IEA --
GO:0005813 centrosome IDA --
GO:0005819 colocalizes_with spindle IDA 11943150
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAPRE1: view

Pathways for MAPRE1 Gene

genes like me logo Genes that share pathways with MAPRE1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MAPRE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006996 organelle organization TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with MAPRE1: view

Compounds for MAPRE1 Gene

(2) Novoseek inferred chemical compound relationships for MAPRE1 Gene

Compound -log(P) Hits PubMed IDs
mal-3 84 2
nocodazole 58.6 4
genes like me logo Genes that share compounds with MAPRE1: view

Transcripts for MAPRE1 Gene

mRNA/cDNA for MAPRE1 Gene

(655) Selected AceView cDNA sequences:
(9) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAPRE1 Gene

Microtubule-associated protein, RP/EB family, member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAPRE1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPRE1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - -
SP6: -
SP7:

Relevant External Links for MAPRE1 Gene

GeneLoc Exon Structure for
MAPRE1
ECgene alternative splicing isoforms for
MAPRE1

Expression for MAPRE1 Gene

mRNA expression in normal human tissues for MAPRE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPRE1 Gene

SOURCE GeneReport for Unigene cluster for MAPRE1 Gene Hs.472437

mRNA Expression by UniProt/SwissProt for MAPRE1 Gene

Q15691-MARE1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with MAPRE1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MAPRE1 Gene

Orthologs for MAPRE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAPRE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPRE1 35
  • 99.5 (n)
  • 99.25 (a)
MAPRE1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAPRE1 35
  • 91.83 (n)
  • 96.89 (a)
MAPRE1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
MAPRE1 35
  • 93.9 (n)
  • 97.67 (a)
MAPRE1 36
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mapre1 35
  • 91.31 (n)
  • 96.89 (a)
Mapre1 16
Mapre1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAPRE1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPRE1 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapre1 35
  • 90.14 (n)
  • 96.5 (a)
chicken
(Gallus gallus)
Aves MAPRE1 35
  • 80.3 (n)
  • 90.28 (a)
MAPRE1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPRE1 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mapre1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mapre1 35
  • 73.93 (n)
  • 84.82 (a)
MGC75947 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8649 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
mapre1a 36
  • 71 (a)
OneToMany
mapre1b 35
  • 71.62 (n)
  • 79.92 (a)
mapre1b 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Eb1 36
  • 53 (a)
OneToMany
CG18190 37
  • 38 (a)
Eb1 37
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea ebp-1 36
  • 43 (a)
ManyToMany
ebp-3 36
  • 31 (a)
ManyToMany
VW02B12L.3 37
  • 34 (a)
Y59A8B.7 37
  • 55 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR024W 35
  • 49.93 (n)
  • 43.51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BIM1 35
  • 50.57 (n)
  • 42.67 (a)
BIM1 36
  • 28 (a)
OneToMany
BIM1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B11550g 35
  • 48.92 (n)
  • 41.13 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons EB1C 35
  • 50.28 (n)
  • 41.88 (a)
rice
(Oryza sativa)
Liliopsida Os10g0498900 35
  • 50.88 (n)
  • 43.42 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00243 35
  • 50.63 (n)
  • 45.61 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mal3 35
  • 48.18 (n)
  • 41.05 (a)
Species with no ortholog for MAPRE1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPRE1 Gene

ENSEMBL:
Gene Tree for MAPRE1 (if available)
TreeFam:
Gene Tree for MAPRE1 (if available)

Paralogs for MAPRE1 Gene

Paralogs for MAPRE1 Gene

Selected SIMAP similar genes for MAPRE1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MAPRE1 Gene

genes like me logo Genes that share paralogs with MAPRE1: view

Variants for MAPRE1 Gene

Sequence variations from dbSNP and Humsavar for MAPRE1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs8183 -- 32,850,362(+) TTTTT(C/T)TACTT utr-variant-3-prime
rs14688 -- 32,850,276(+) TCTTT(A/T)GTGGC utr-variant-3-prime
rs20654 -- 32,830,490(+) CTTCC(A/G)GTGTC intron-variant
rs187178 -- 32,822,473(+) CGTGC(A/G)AGATG intron-variant
rs242533 -- 32,844,472(+) ttttg(G/T)ggcgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPRE1 Gene

Variant ID Type Subtype PubMed ID
nsv833957 CNV Gain+Loss 17160897
nsv833959 CNV Loss 17160897
nsv179909 CNV Loss 16902084
nsv179907 CNV Loss 16902084
esv2722348 CNV Deletion 23290073

Relevant External Links for MAPRE1 Gene

HapMap Linkage Disequilibrium report
MAPRE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPRE1 Gene

Disorders for MAPRE1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for MAPRE1 Gene including...

Search for MAPRE1 Gene in MalaCards »

(4) Novoseek inferred disease relationships for MAPRE1 Gene

Disease -log(P) Hits PubMed IDs
familial adenomatous polyposis 83.8 11
colorectal cancer 24.5 3
chromosomal aberrations 6.44 1
tumors 2.75 9

Relevant External Links for MAPRE1

Genetic Association Database (GAD)
MAPRE1
Human Genome Epidemiology (HuGE) Navigator
MAPRE1
genes like me logo Genes that share disorders with MAPRE1: view

No data available for UniProtKB/Swiss-Prot for MAPRE1 Gene

Publications for MAPRE1 Gene

  1. APC binds to the novel protein EB1. (PMID: 7606712) Su L.-K. … Kinzler K.W. (Cancer Res. 1995) 2 3 4 23
  2. The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain. (PMID: 10226031) Berrueta L. … Bierer B.E. (Curr. Biol. 1999) 3 4 23
  3. Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome. (PMID: 12388762) Askham J.M. … Morrison E.E. (Mol. Biol. Cell 2002) 3 4 23
  4. Crystal structure of the amino-terminal microtubule-binding domain of end-binding protein 1 (EB1). (PMID: 12857735) Hayashi I. … Ikura M. (J. Biol. Chem. 2003) 3 4 23
  5. Structural insights into the EB1-APC interaction. (PMID: 15616574) Honnappa S. … Steinmetz M.O. (EMBO J. 2005) 3 4 23

Products for MAPRE1 Gene

Sources for MAPRE1 Gene

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