Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MAPRE1 Gene

Aliases for MAPRE1 Gene

  • Microtubule Associated Protein RP/EB Family Member 1 2 3 5
  • Adenomatous Polyposis Coli-Binding Protein EB1 2 3
  • APC-Binding Protein EB1 3 4
  • End-Binding Protein 1 3 4
  • EB1 3 4
  • Microtubule-Associated Protein, RP/EB Family, Member 1 3

External Ids for MAPRE1 Gene

Previous GeneCards Identifiers for MAPRE1 Gene

  • GC20P031166
  • GC20P032076
  • GC20P032123
  • GC20P030871
  • GC20P031407
  • GC20P028194

Summaries for MAPRE1 Gene

Entrez Gene Summary for MAPRE1 Gene

  • The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPRE1 Gene

MAPRE1 (Microtubule Associated Protein RP/EB Family Member 1) is a Protein Coding gene. Diseases associated with MAPRE1 include adenomatous polyposis coli. Among its related pathways are Cytoskeletal Signaling and DNA Damage. GO annotations related to this gene include poly(A) RNA binding and protein C-terminus binding. An important paralog of this gene is MAPRE2.

UniProtKB/Swiss-Prot for MAPRE1 Gene

  • Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.

Gene Wiki entry for MAPRE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPRE1 Gene

Genomics for MAPRE1 Gene

Regulatory Elements for MAPRE1 Gene

Enhancers for MAPRE1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAPRE1 on UCSC Golden Path with GeneCards custom track

Promoters for MAPRE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAPRE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAPRE1 Gene

Chromosome:
20
Start:
32,819,780 bp from pter
End:
32,850,405 bp from pter
Size:
30,626 bases
Orientation:
Plus strand

Genomic View for MAPRE1 Gene

Genes around MAPRE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPRE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPRE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPRE1 Gene

Proteins for MAPRE1 Gene

  • Protein details for MAPRE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15691-MARE1_HUMAN
    Recommended name:
    Microtubule-associated protein RP/EB family member 1
    Protein Accession:
    Q15691
    Secondary Accessions:
    • B2R6I7
    • E1P5M8
    • Q3KQS8

    Protein attributes for MAPRE1 Gene

    Size:
    268 amino acids
    Molecular mass:
    29999 Da
    Quaternary structure:
    • Homodimer. Heterodimer with MAPRE3. Interacts with DCTN1, DCTN2, DIAPH1, DIAPH2, TERF1 and dynein intermediate chain. Interacts with APC (via C-terminal domain), CLASP2, DST, KIF2C and STIM1; probably required for their targeting to the growing microtubule plus ends. Interacts with MTUS2; interaction is direct and probably targets MTUS2 to microtubules. Interacts with APC2. Interacts with CLASP1. Interacts with CDK5RAP2. Interacts with MACF1 (By similarity). Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity). Interacts with KCNAB2 (By similarity). Interacts (via C-terminus) with CLIP1. Interacts with SLAIN2. Interacts with KIF18B; this interaction is required for efficient accumulation of KIF18B at microtubule plus ends. Interacts with MISP. Interacts with KNSTRN. Interacts with NCKAP5L (PubMed:26485573).

    Three dimensional structures from OCA and Proteopedia for MAPRE1 Gene

neXtProt entry for MAPRE1 Gene

Proteomics data for MAPRE1 Gene at MOPED

Post-translational modifications for MAPRE1 Gene

  • Ubiquitination at Lys 83, Lys 100, Lys 174, Lys 182, and Lys 212
  • Modification sites at PhosphoSitePlus

Other Protein References for MAPRE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAPRE1 (EB1)

No data available for DME Specific Peptides for MAPRE1 Gene

Domains & Families for MAPRE1 Gene

Protein Domains for MAPRE1 Gene

Suggested Antigen Peptide Sequences for MAPRE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15691

UniProtKB/Swiss-Prot:

MARE1_HUMAN :
  • Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.
  • Belongs to the MAPRE family.
Domain:
  • Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 EB1 C-terminal domain.
Family:
  • Belongs to the MAPRE family.
genes like me logo Genes that share domains with MAPRE1: view

No data available for Gene Families for MAPRE1 Gene

Function for MAPRE1 Gene

Molecular function for MAPRE1 Gene

GENATLAS Biochemistry:
Microtubule-associated protein, RP/EB family, member 1,component of the microtubule cytoskeleton,colocalyzing both to cytoplasmic microtubules in interphase cells and to spindle microtubules during mitosis,associating with the C terminal region of APC
UniProtKB/Swiss-Prot Function:
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.
genes like me logo Genes that share phenotypes with MAPRE1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAPRE1 Gene

Localization for MAPRE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPRE1 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with the microtubule network at the growing distal tip of microtubules. Also enriched at the centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPRE1 Gene COMPARTMENTS Subcellular localization image for MAPRE1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
plasma membrane 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for MAPRE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 21399614
GO:0035371 microtubule plus-end IEA --
genes like me logo Genes that share ontologies with MAPRE1: view

Pathways & Interactions for MAPRE1 Gene

genes like me logo Genes that share pathways with MAPRE1: view

Pathways by source for MAPRE1 Gene

SIGNOR curated interactions for MAPRE1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAPRE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007062 sister chromatid cohesion TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with MAPRE1: view

Drugs & Compounds for MAPRE1 Gene

(1) Drugs for MAPRE1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for MAPRE1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAPRE1: view

Transcripts for MAPRE1 Gene

mRNA/cDNA for MAPRE1 Gene

Unigene Clusters for MAPRE1 Gene

Microtubule-associated protein, RP/EB family, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPRE1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - -
SP6: -
SP7:

Relevant External Links for MAPRE1 Gene

GeneLoc Exon Structure for
MAPRE1
ECgene alternative splicing isoforms for
MAPRE1

Expression for MAPRE1 Gene

mRNA expression in normal human tissues for MAPRE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPRE1 Gene



SOURCE GeneReport for Unigene cluster for MAPRE1 Gene Hs.472437

mRNA Expression by UniProt/SwissProt for MAPRE1 Gene

Q15691-MARE1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with MAPRE1: view

Protein tissue co-expression partners for MAPRE1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for MAPRE1 Gene

Orthologs for MAPRE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAPRE1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAPRE1 35
  • 91.83 (n)
  • 96.89 (a)
MAPRE1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPRE1 35
  • 93.9 (n)
  • 97.67 (a)
-- 36
  • 84 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
MAPRE1 36
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mapre1 35
  • 91.31 (n)
  • 96.89 (a)
Mapre1 16
Mapre1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAPRE1 35
  • 99.5 (n)
  • 99.25 (a)
MAPRE1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapre1 35
  • 90.14 (n)
  • 96.5 (a)
oppossum
(Monodelphis domestica)
Mammalia MAPRE1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPRE1 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAPRE1 35
  • 80.3 (n)
  • 90.28 (a)
MAPRE1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPRE1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapre1 35
  • 73.93 (n)
  • 84.82 (a)
MGC75947 35
African clawed frog
(Xenopus laevis)
Amphibia mapre1-prov 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
mapre1b 35
  • 71.62 (n)
  • 79.92 (a)
mapre1a 36
  • 71 (a)
OneToMany
mapre1b 36
  • 62 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8649 35
fruit fly
(Drosophila melanogaster)
Insecta CG18190 37
  • 38 (a)
Eb1 37
  • 52 (a)
Eb1 36
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea VW02B12L.3 37
  • 34 (a)
Y59A8B.7 37
  • 55 (a)
ebp-1 36
  • 43 (a)
ManyToMany
ebp-3 36
  • 31 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR024W 35
  • 49.93 (n)
  • 43.51 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B11550g 35
  • 48.92 (n)
  • 41.13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BIM1 35
  • 50.57 (n)
  • 42.67 (a)
BIM1 36
  • 28 (a)
OneToMany
BIM1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons EB1C 35
  • 50.28 (n)
  • 41.88 (a)
rice
(Oryza sativa)
Liliopsida Os10g0498900 35
  • 50.88 (n)
  • 43.42 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00243 35
  • 50.63 (n)
  • 45.61 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mal3 35
  • 48.18 (n)
  • 41.05 (a)
Species with no ortholog for MAPRE1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPRE1 Gene

ENSEMBL:
Gene Tree for MAPRE1 (if available)
TreeFam:
Gene Tree for MAPRE1 (if available)

Paralogs for MAPRE1 Gene

Paralogs for MAPRE1 Gene

(2) SIMAP similar genes for MAPRE1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MAPRE1 Gene

genes like me logo Genes that share paralogs with MAPRE1: view

Variants for MAPRE1 Gene

Sequence variations from dbSNP and Humsavar for MAPRE1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs8183 -- 32,850,362(+) TTTTT(C/T)TACTT utr-variant-3-prime
rs14688 -- 32,850,276(+) TCTTT(A/T)GTGGC utr-variant-3-prime
rs20654 -- 32,830,490(+) CTTCC(A/G)GTGTC intron-variant
rs187178 -- 32,822,473(+) CGTGC(A/G)AGATG intron-variant
rs447749 -- 32,842,059(+) GTAGC(C/T)AACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPRE1 Gene

Variant ID Type Subtype PubMed ID
nsv833957 CNV Gain+Loss 17160897
nsv833959 CNV Loss 17160897
nsv179909 CNV Loss 16902084
nsv179907 CNV Loss 16902084
esv2722348 CNV Deletion 23290073

Variation tolerance for MAPRE1 Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPRE1 Gene

HapMap Linkage Disequilibrium report
MAPRE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPRE1 Gene

Disorders for MAPRE1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAPRE1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
adenomatous polyposis coli
  • brain tumor-polyposis syndrome 2
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAPRE1

Genetic Association Database (GAD)
MAPRE1
Human Genome Epidemiology (HuGE) Navigator
MAPRE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPRE1
genes like me logo Genes that share disorders with MAPRE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPRE1 Gene

Publications for MAPRE1 Gene

  1. APC binds to the novel protein EB1. (PMID: 7606712) Su L.-K. … Kinzler K.W. (Cancer Res. 1995) 2 3 4 23 67
  2. TIP150 interacts with and targets MCAK at the microtubule plus ends. (PMID: 19543227) Jiang K. … Yao X. (EMBO Rep. 2009) 3 23
  3. Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6. (PMID: 19737819) Zilberman Y. … Bershadsky A. (J. Cell. Sci. 2009) 3 23
  4. Proteomic profiling reveals the prognostic value of adenomatous polyposis coli-end-binding protein 1 in hepatocellular carcinoma. (PMID: 18937283) Orimo T. … Kondo T. (Hepatology 2008) 3 23
  5. Microtubule binding proteins CLIP-170, EB1, and p150Glued form distinct plus-end complexes. (PMID: 16455083) Ligon L.A. … Holzbaur E.L. (FEBS Lett. 2006) 3 23

Products for MAPRE1 Gene

Sources for MAPRE1 Gene

Content