MAPRE1 Gene
protein-coding GIFtS: 62
GCID: GC20P031407
|
|
microtubule-associated protein, RP/EB family, member 1
| |
Aliases
for MAPRE1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Microtubule-Associated Protein, RP/EB Family, Member 11 2 | | EB11 2 3 5 | | End-Binding Protein 12 3 | | APC-Binding Protein EB12 3 | | Adenomatous Polyposis Coli-Binding Protein EB12 | | Microtubule-Associated Protein RP/EB Family Member 12 |
Export aliases for MAPRE1 gene to outside databasesPrevious GC identifers: GC20P031166 GC20P032076 GC20P032123 GC20P030871 GC20P028194 |
Summaries
for MAPRE1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAPRE1:
The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated infamilial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends,in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. Theprotein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein.Because of these associations, it is thought that this protein is involved in the regulation of microtubule structuresand chromosome stability. This gene is a member of the RP/EB family. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MARE1_HUMAN, Q15691Function: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotescytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules andanchoring them at centrosomes. May play a role in cell migration
Gene Wiki entry for MAPRE1
|
Genomic Views
for MAPRE1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAPRE1 gene promoter:
N-Myc Egr-3 AML1a HFH-1 NF-YC LCR-F1 Evi-1 E47 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAPRE1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPRE1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q11.1-q11.23 Ensembl cytogenetic band: 20q11.21 HGNC cytogenetic band: 20q11.1-q11.3MAPRE1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P031407: view genomic region
(about GC identifiers)
Start:
|
31,407,699 bp from pter |
End:
|
31,438,211 bp from pter |
Size:
|
30,513 bases |
Orientation:
|
plus strand |
|
Proteins
for MAPRE1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MARE1_HUMAN, Q15691 (See
protein sequence)Recommended Name: Microtubule-associated protein RP/EB family member 1 Size: 268 amino acids; 29999 Da
Subunit: Homodimer. Heterodimer with MAPRE3. Interacts with DCTN1, DCTN2, DIAPH1, DIAPH2, TERF1 and dynein intermediatechain. Interacts with APC (via C-terminal domain), CLASP2, DST, KIF2C and STIM1; probably required for their targetingto the growing microtubule plus ends. Interacts with MTUS2; interaction is direct and probably targets MTUS2 tomicrotubules. Interacts with APC2. Interacts with CLASP1. Interacts with CDK5RAP2. Interacts with MACF1 (Bysimilarity). Interacts (via C-terminus) with CLIP1. Interacts with SLAIN2. Interacts with KIF18B; this interaction isrequired for efficient accumulation of KIF18B at microtubule plus ends
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Note=Associated with themicrotubule network at the growing distal tip of microtubules. Also enriched at the centrosome
6/14 PDB 3D structures from  and Proteopedia  for MAPRE1 (see all 14):1PA7 (3D)
1TXQ (3D)
1UEG (3D)
1VKA (3D)
1WU9 (3D)
1YIB (3D)
Secondary accessions: B2R6I7 E1P5M8 Q3KQS8Explore the universe of human proteins at neXtProt for MAPRE1: NX_Q15691
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15691
MAPRE1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036457.1
ENSEMBL proteins: ENSP00000364721 Reactome Protein details: Q15691
Human Recombinant Protein Products:
Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table
MAPRE1 for ontologies About GeneDecksing
MAPRE1 Antibody Products:
Assay Products for MAPRE1: |
Protein
Domains /
Families
for MAPRE1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAPRE1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15691ProtoNet protein and cluster: Q15691 2 Blocks protein families: IPB001715 Calponin-like actin-binding IPB004953 EB1 protein
UniProtKB/Swiss-Prot: MARE1_HUMAN, Q15691Domain: Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved inmicrotubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1Similarity: Belongs to the MAPRE familySimilarity: Contains 1 CH (calponin-homology) domainSimilarity: Contains 1 EB1 C-terminal domain |
Function
for MAPRE1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MARE1_HUMAN, Q15691Function: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotescytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules andanchoring them at centrosomes. May play a role in cell migration Genatlas biochemistry entry for MAPRE1:Microtubule-associated protein, RP/EB family, member 1,component of the microtubule cytoskeleton,colocalyzing both tocytoplasmic microtubules in interphase cells and to spindle microtubules during mitosis,associating with the Cterminal region of APC
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPRE1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPRE1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MAPRE1 (NM_012325) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAPRE1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPRE1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPRE1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
MAPRE1 for ontologies About GeneDecksing
|
Pathways & Interactions
for MAPRE1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Recruitment of mitotic centrosome proteins and complexes | | | 2 | M Phase | | | 3 | Resolution of Sister Chromatid Cohesion | | | 4 | Cell Cycle | | | 5 | Cytoskeletal Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPRE1
2 
Cell Signaling Technology (CST) Pathways for MAPRE1
1  BioSystems Pathway for MAPRE1
5/16 
Reactome Pathways for MAPRE1 (see all 16)
MAPRE1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPRE1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/298 Interacting proteins for MAPRE1 (Q156911, 2, 3 ENSP000003647214) via UniProtKB, MINT, STRING, and/or I2D (see all 298)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| TERF1 | P542741, 2, 3, ENSP000002766034 | EBI-1004115,EBI-710997 MINT-13642 MINT-17741 MINT-17739 MINT-17740 I2D:
score=5 STRING: ENSP00000276603 | | MTUS2 | Q5JR592, 3 | MINT-7256299 MINT-7256149 MINT-7256258 MINT-7256350 MINT-7256110 MINT-7256165 MINT-7256121 I2D:
score=1 | | KIF2C | Q996612, 3, ENSP000003612984 | MINT-7256299 MINT-7256258 MINT-7256324 MINT-7256284 I2D:
score=2 STRING: ENSP00000361298 | | APC | P250541, 3, ENSP000002574304 | EBI-1004115,EBI-727707 I2D:
score=5 STRING: ENSP00000257430 | | ENSG00000206435 | P305043 | I2D:
score=1 |
About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
MAPRE1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MAPRE1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MAPRE1 for compounds About GeneDecksing
 Browse Tocris compounds for MAPRE1
2 Novoseek chemical compound relationships for MAPRE1 gene About this table
Search CenterWatch for drugs/clinical trials and news about MAPRE1 / MARE1
|
Transcripts
for MAPRE1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAPRE1 gene: NM_012325.2 Unigene Cluster for MAPRE1: Microtubule-associated protein, RP/EB family, member 1 Hs.472437 [show with all ESTs]Unigene Representative Sequence: NM_0123251 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000375571(uc002wyh.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPRE1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPRE1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MAPRE1 (NM_012325) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAPRE1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPRE1 |
Additional cDNA sequence: AK297273.1 AK310817.1 AK312590.1 BC040410.1 BC106068.1 BC109281.3 BC128441.1 BC128442.1 U24166.1 19 DOTS entries: DT.92387361 DT.452649 DT.100669761 DT.97760068 DT.95373861 DT.100669754 DT.100669759 DT.100669764 DT.121228124 DT.100047713 DT.120824829 DT.91762795 DT.91762797 DT.100047842 DT.120824795 DT.95264231 DT.100700710 DT.120824794 DT.120824853 24/655 AceView cDNA sequences (see all 655): CK903837 AI291676 AI587464 BM667248 BU170433 AA580879 BU507783 AI355938 AA665868 BG775948 AA960880 BU609046 BI793142 BP340954 CB146269 AW474024 AA644616 AA593841 BU857993 CB131068 AA452323 AI285247 BM785435 AA252119
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MAPRE1 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b |
|---|
|
| SP1: | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MAPRE1
|
Expression
for MAPRE1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAPRE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTGTGTGG
About this image
See MAPRE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAPRE1
SOURCE GeneReport for Unigene cluster: Hs.472437
UniProtKB/Swiss-Prot: MARE1_HUMAN, Q15691Tissue specificity: Ubiquitously expressed
SABiosciences Expression via Pathway-Focused PCR Arrays including MAPRE1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAPRE1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAPRE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPRE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPRE1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPRE1 |
Orthologs
for MAPRE1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MAPRE1 gene from 10/33 species (see all 33) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mapre11 , 5 |
microtubule-associated protein, RP/EB family, member more1, 5 |
91.54(n)1
97.01(a)1 |
|
2 (75.95 cM)5
135891 NM_007896.31 NP_031922.11
1537412745 |
chicken
(Gallus gallus) |
Aves |
MAPRE11 |
microtubule-associated protein, RP/EB family, member more |
80.62(n)
90.31(a) |
|
419288 NM_001030860.1 NP_001026031.1 |
lizard
(Anolis carolinensis) |
Reptilia |
MAPRE16 |
-- |
85(a) |
1 ↔ 1 |
GL343873.1(91780-107226) |
African clawed frog
(Xenopus laevis) |
Amphibia |
mapre1-prov2 |
microtubule-associated protein, RP/EB family, member more |
82.03(n) |
|
AB067727.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC044167.12 |
-- |
79.56(n) |
|
334135 BC044167.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Eb13 |
microtubule-based process microtubule
binding |
52(a)
(best of 2) |
|
42C7 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
Y59A8B.73 |
-- |
55(a)
(best of 2) |
|
V(18046176-18054907) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
BIM1(YER016W)4
BIM11 |
Microtubule-binding protein that together with Kar9p more4
Bim1p1 |
50.64(n)1
41.2(a)1 |
|
5(188277-189311)4
8567361, 4 NP_010932.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
EB1C1 |
end binding protein 1C |
50.28(n)
41.88(a) |
|
836862 NM_126127.3 NP_201528.1 |
rice
(Oryza sativa) |
Liliopsida |
Os10g04989001 |
hypothetical protein |
50.88(n)
43.42(a) |
|
4349023 NM_001071507.1 NP_001064972.1 |
ENSEMBL Gene Tree for MAPRE1 (if available)
TreeFam Gene Tree for MAPRE1 (if available) |
Paralogs
for MAPRE1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAPRE1 gene
- MAPRE22 MAPRE32
2 SIMAP similar genes for MAPRE1 using alignment to 2 protein entries: MARE1_HUMAN (see all proteins):MAPRE3 MAPRE2
MAPRE1 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for MAPRE1
PGOHUM00000241008 PGOHUM00000245494 PGOHUM00000249512
|
Genomic Variants
for MAPRE1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAPRE1 (31407699 - 31438211 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for MAPRE1
2 CNVs: 5133 6087
1 Indel: 12177 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAPRE1 |
|
Disorders
/ Diseases
for MAPRE1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAPRE1 for disorders About GeneDecksing
OMIM gene information: 603108
OMIM disorders: --
20  diseases for MAPRE1: About MalaCardsadenomatous polyposis coli polyposis colorectal cancer familial adenomatous polyposis
pediatric ependymoma gardner syndrome esophageal squamous cell carcinoma squamous cell carcinoma
ependymoma acute lymphoblastic leukemia lymphoblastic leukemia was-related disorders
hepatocellular carcinoma esophagitis gastric cancer leukemia
carcinoma breast cancer malaria neuronitis
4 Novoseek disease relationships for MAPRE1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: MAPRE1 (1 document)
Export disorders for MAPRE1 gene to outside databases
|
Publications
for MAPRE1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAPRE1 gene, integrated from 9 sources (see all 113):
(articles sorted by number of sources associating them with MAPRE1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- APC binds to the novel protein EB1. (PubMed id 7606712)1, 2, 3, 9 Su L.-K.... Kinzler K.W. (1995)
- The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules. (PubMed id 9724749)1, 2, 3 Berrueta L.... Bierer B.E. (1998)
- Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome. (PubMed id 12388762)1, 2, 9 Askham J.M.... Morrison E.E. (2002)
- Crystal structure of the amino-terminal microtubule-binding domain of end-binding protein 1 (EB1). (PubMed id 12857735)1, 2, 9 Hayashi I. and Ikura M. (2003)
- The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain. (PubMed id 10226031)1, 2, 9 Berrueta L.... Bierer B.E. (1999)
- TIP150 interacts with and targets MCAK at the microtubule plus ends. (PubMed id 19543227)1, 2, 9 Jiang K....Yao X. (2009)
- Structural insights into the EB1-APC interaction. (PubMed id 15616574)1, 2, 9 Honnappa S.... Steinmetz M.O. (2005)
- Mammalian end binding proteins control persistent microtubule growth. (PubMed id 19255245)1, 2 Komarova Y....Akhmanova A. (2009)
- An EB1-binding motif acts as a microtubule tip locali zation signal. (PubMed id 19632184)1, 2 Honnappa S....Steinmetz M.O. (2009)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
|
External Searches for MAPRE1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAPRE1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing MAPRE1 gene
(According to HUGE)
About This Section
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Specialized Databases showing MAPRE1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for MAPRE1 gene:
Search GeneIP for patents involving MAPRE1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MAPRE1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MAPRE1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPRE1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAPRE1 | | | OriGene Protein Over-expression Lysate for MAPRE1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAPRE1 | | OriGene 3'-UTR Clone for MAPRE1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPRE1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPRE1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MAPRE1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MAPRE1 | | OriGene Custom Protein Services for MAPRE1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAPRE1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAPRE1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPRE1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPRE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPRE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPRE1 |
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| | Antibodies & Assays for MAPRE1 (EB1) |
| | | | Search Tocris compounds for MAPRE1 |
| |  |  |  |  | | | | | | Recombinant Protein for MAPRE1 |
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 | | | MAPRE1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPRE1 |
|  |  |  | | | | ThermoFisher Antibody for MAPRE1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPRE1 |
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