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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPRE1 Gene

protein-coding   GIFtS: 63
GCID: GC20P031407

Microtubule-Associated Protein, RP/EB Family, Member 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Microtubule-Associated Protein, RP/EB Family, Member 11 2
EB12 3 5
Adenomatous Polyposis Coli-Binding Protein EB11 2
End-Binding Protein 12 3
APC-Binding Protein EB12 3
Microtubule-Associated Protein RP/EB Family Member 12

External Ids:    HGNC: 68901   Entrez Gene: 229192   Ensembl: ENSG000001013677   OMIM: 6031085   UniProtKB: Q156913   

Export aliases for MAPRE1 gene to outside databases

Previous GC identifers: GC20P031166 GC20P032076 GC20P032123 GC20P030871 GC20P028194


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAPRE1 Gene:
The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in
familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing
ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle
microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of
cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation
of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. (provided by
RefSeq, Jul 2008)

GeneCards Summary for MAPRE1 Gene: 
MAPRE1 (microtubule-associated protein, RP/EB family, member 1) is a protein-coding gene. Diseases associated with MAPRE1 include gardner syndrome, and pediatric ependymoma, and among its related super-pathways are G2/M Transition and Mitotic Anaphase. GO annotations related to this gene include microtubule plus-end binding and protein C-terminus binding. An important paralog of this gene is MAPRE3.

UniProtKB/Swiss-Prot: MARE1_HUMAN, Q15691
Function: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton.
Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing
microtubules and anchoring them at centrosomes. May play a role in cell migration

Gene Wiki entry for MAPRE1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPRE1 gene promoter:
         N-Myc   Egr-3   AML1a   HFH-1   NF-YC   LCR-F1   Evi-1   E47   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAPRE1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAPRE1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPRE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.1-q11.23   Ensembl cytogenetic band:  20q11.21   HGNC cytogenetic band: 20q11.1-q11.3

MAPRE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPRE1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P031407:  view genomic region     (about GC identifiers)

Start:
31,407,699 bp from pter      End:
31,438,211 bp from pter
Size:
30,513 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MARE1_HUMAN, Q15691 (See protein sequence)
Recommended Name: Microtubule-associated protein RP/EB family member 1  
Size: 268 amino acids; 29999 Da
Subunit: Homodimer. Heterodimer with MAPRE3. Interacts with DCTN1, DCTN2, DIAPH1, DIAPH2, TERF1 and dynein
intermediate chain. Interacts with APC (via C-terminal domain), CLASP2, DST, KIF2C and STIM1; probably required
for their targeting to the growing microtubule plus ends. Interacts with MTUS2; interaction is direct and
probably targets MTUS2 to microtubules. Interacts with APC2. Interacts with CLASP1. Interacts with CDK5RAP2.
Interacts with MACF1 (By similarity). Interacts (via C-terminus) with CLIP1. Interacts with SLAIN2. Interacts
with KIF18B; this interaction is required for efficient accumulation of KIF18B at microtubule plus ends.
Interacts with MISP
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Note=Associated with the microtubule network at the growing distal tip of microtubules. Also enriched at the
centrosome
6/14 PDB 3D structures from and Proteopedia for MAPRE1 (see all 14):
1PA7 (3D)        1TXQ (3D)        1UEG (3D)        1VKA (3D)        1WU9 (3D)        1YIB (3D)    
Secondary accessions: B2R6I7 E1P5M8 Q3KQS8

Explore the universe of human proteins at neXtProt for MAPRE1: NX_Q15691

Explore proteomics data for MAPRE1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15691

  • MAPRE1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAPRE1 Protein Expression
    REFSEQ proteins: NP_036457.1  
    ENSEMBL proteins: 
     ENSP00000364721  
    Reactome Protein details: Q15691
    Human Recombinant Protein Products for MAPRE1: 
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    Cloud-Clone Corp. Proteins for MAPRE1 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IEA--
    GO:0005813centrosome IDA--
    GO:0005819colocalizes with spindle IDA11943150
    GO:0005829cytosol TAS--

    MAPRE1 for ontologies           About GeneDecksing



    MAPRE1 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for MAPRE1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001715 CH-domain
     IPR027328 MAPRE
     IPR004953 EB1_C

    Graphical View of Domain Structure for InterPro Entry Q15691

    ProtoNet protein and cluster: Q15691

    2 Blocks protein domains:
    IPB001715 Calponin-like actin-binding
    IPB004953 EB1 protein


    UniProtKB/Swiss-Prot: MARE1_HUMAN, Q15691
    Domain: Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved
    in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC
    and DCTN1
    Similarity: Belongs to the MAPRE family
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 EB1 C-terminal domain


    MAPRE1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MARE1_HUMAN, Q15691
    Function: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton.
    Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing
    microtubules and anchoring them at centrosomes. May play a role in cell migration

         Genatlas biochemistry entry for MAPRE1:
    Microtubule-associated protein, RP/EB family, member 1,component of the microtubule cytoskeleton,colocalyzing both
    to cytoplasmic microtubules in interphase cells and to spindle microtubules during mitosis,associating with the C
    terminal region of APC

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10226031
    GO:0008017microtubule binding ----
    GO:0008022protein C-terminus binding TAS7606712
    GO:0051010microtubule plus-end binding IDA15631994
         
    MAPRE1 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAPRE1 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Recruitment of mitotic centrosome proteins and complexes
    Recruitment of mitotic centrosome proteins and complexes0.83
    Mitotic G2-G2/M phases0.81
    Centrosome maturation0.83
    Loss of Nlp from mitotic centrosomes0.78
    G2/M Transition0.83
    Loss of proteins required for interphase microtubule organization,from the centrosome0.78
    2M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    3Resolution of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion0.93
    Mitotic Prometaphase0.93
    4Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    5PAK Pathway
    Epithelial Adherens Junctions0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPRE1
        Remodeling of Adherens Junctions
    Epithelial Adherens Junctions

    2 Cell Signaling Technology (CST) Pathways for MAPRE1
        Cell Cycle / Checkpoint Control
    Cytoskeletal Signaling

    2 BioSystems Pathways for MAPRE1
        N-cadherin signaling events
    Regulation of Microtubule Cytoskeleton

    5/15        Reactome Pathways for MAPRE1 (see all 15)
        Mitotic Metaphase and Anaphase
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Centrosome maturation
    Mitotic Anaphase



    MAPRE1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPRE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/298 Interacting proteins for MAPRE1 (Q156911, 2, 3 ENSP000003647214) via UniProtKB, MINT, STRING, and/or I2D (see all 298)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TERF1P542741, 2, 3, ENSP000002766034EBI-1004115,EBI-710997 MINT-13642 MINT-17741 MINT-17739 MINT-17740 I2D: score=5 STRING: ENSP00000276603
    MTUS2Q5JR592, 3MINT-7256299 MINT-7256149 MINT-7256258 MINT-7256350 MINT-7256110 MINT-7256165 MINT-7256121 I2D: score=1 
    KIF2CQ996612, 3, ENSP000003612984MINT-7256299 MINT-7256258 MINT-7256324 MINT-7256284 I2D: score=2 STRING: ENSP00000361298
    APCP250541, 3, ENSP000002574304EBI-1004115,EBI-727707 I2D: score=5 STRING: ENSP00000257430
    ENSG00000206435P305043I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--
    GO:0008283cell proliferation TAS7606712
    GO:0031115negative regulation of microtubule polymerization IDA11943150

    MAPRE1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAPRE1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MAPRE1 (MARE1)

    2 Novoseek inferred chemical compound relationships for MAPRE1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mal-3 84 2 10226031 (1), 16294010 (1)
    nocodazole 58.6 4 10030671 (2), 12475954 (1), 14620743 (1)

    Search CenterWatch for drugs/clinical trials and news about MAPRE1 / MARE1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAPRE1 gene: 
    NM_012325.2  

    Unigene Cluster for MAPRE1:

    Microtubule-associated protein, RP/EB family, member 1
    Hs.472437  [show with all ESTs]
    Unigene Representative Sequence: NM_012325
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000375571(uc002wyh.3)
    miRNA
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    Additional mRNA sequence: 

    AK297273.1 AK310817.1 AK312590.1 BC040410.1 BC106068.1 BC109281.3 BC128441.1 BC128442.1 
    U24166.1 

    19 DOTS entries:

    DT.92387361  DT.452649  DT.100669761  DT.97760068  DT.95373861  DT.100669754  DT.100669759  DT.100669764 
    DT.121228124  DT.100047713  DT.120824829  DT.91762795  DT.91762797  DT.100047842  DT.120824795  DT.95264231 
    DT.100700710  DT.120824794  DT.120824853 

    24/655 AceView cDNA sequences (see all 655):

    AA310071 AA644616 CB143986 AI291676 AI754403 AA242902 AI879986 AI285247 
    BF726622 AA670208 BM480051 AI192401 BM766131 AL559663 CD644080 AI383000 
    Z38235 BU521173 BQ221575 BM929468 CR592459 CB145639 BM835287 BM803639 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MAPRE1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
    SP1:              -     -     -     -     -                                                                                 
    SP2:                          -     -     -                                                                                 
    SP3:                          -     -     -                                                                                 
    SP4:                          -     -     -                 -     -                                                         
    SP5:                          -     -     -           -     -     -                                                         


    ECgene alternative splicing isoforms for MAPRE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPRE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTGTGTGG
    MAPRE1 Expression
    About this image


    See MAPRE1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPRE1

    SOURCE GeneReport for Unigene cluster: Hs.472437

    UniProtKB/Swiss-Prot: MARE1_HUMAN, Q15691
    Tissue specificity: Ubiquitously expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAPRE1: 
              Cytoskeleton Regulators in human mouse rat
              Adherens Junctions in human mouse rat
              Telomeres & Telomerase in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPRE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAPRE1 gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapre11 , 5 microtubule-associated protein, RP/EB family, member more1, 5 91.54(n)1
    97.01(a)1
      2 (75.95 cM)5
    135891  NM_007896.31  NP_031922.11 
     1537412745 
    chicken
    (Gallus gallus)
    Aves MAPRE11 microtubule-associated protein, RP/EB family, member more 80.62(n)
    90.31(a)
      419288  NM_001030860.1  NP_001026031.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAPRE16
    microtubule-associated protein, RP/EB family, memb...
    76(a)
    1 ↔ 1
    GL343873.1(90755-115107)
    African clawed frog
    (Xenopus laevis)
    Amphibia mapre1-prov2 microtubule-associated protein, RP/EB family, member more 82.03(n)    AB067727.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC044167.12   -- 79.56(n)   334135  BC044167.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eb13 microtubule-based process microtubule
    binding
    52(a)
    (best of 2)
      42C7   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y59A8B.73   -- 55(a)
    (best of 2)
      V(18046176-18054907)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BIM1(YER016W)4
    BIM11
    Microtubule-binding protein that together with Kar9p more4
    Bim1p1
    50.64(n)1
    41.2(a)1
      5(188277-189311)4
    8567361, 4  NP_010932.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EB1C1 end binding protein 1C 50.28(n)
    41.88(a)
      836862  NM_126127.3  NP_201528.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g04989001 hypothetical protein 50.88(n)
    43.42(a)
      4349023  NM_001071507.1  NP_001064972.1 


    ENSEMBL Gene Tree for MAPRE1 (if available)
    TreeFam Gene Tree for MAPRE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPRE1 gene
    MAPRE32  MAPRE22  
    2 SIMAP similar genes for MAPRE1 using alignment to 2 protein entries:     MARE1_HUMAN (see all proteins):
    MAPRE2    MAPRE3

    MAPRE1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for MAPRE1
    PGOHUM00000241008 PGOHUM00000245494 PGOHUM00000249512


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/730 SNPs in MAPRE1 are shown (see all 730)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs353434591,2
    C--28220051(+) TGTAC-/TGTATGTATGT
    ATGTATGTATGTA
    TGTAT
    1 -- int10--------
    rs1834078371,2
    --31405999(+) AGAGAC/TGGAGT 1 -- us2k10--------
    rs1489530531,2
    C--31406065(+) CTCGAA/TCTCCT 1 -- us2k10--------
    rs1888015411,2
    --31406067(+) CGAACC/TCCTGG 1 -- us2k10--------
    rs739040471,2
    C,F--31406069(+) AACTCC/TTGGGC 1 -- us2k12Minor allele frequency- T:0.06WA 120
    rs61199741,2
    C,F--31406085(+) cgatcC/Atcctg 1 -- us2k12Minor allele frequency- A:0.07CSA WA 120
    rs761847031,2
    F--31406274(+) TTGGCC/GTCTTT 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1919016041,2
    --31406328(+) TTTTTC/GTTTTT 1 -- us2k10--------
    rs1831059851,2
    --31406413(+) GATTAC/TAGGCG 1 -- us2k10--------
    rs1877873191,2
    --31406417(+) ACAGGC/TGCCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAPRE1 (31407699 - 31438211 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MAPRE1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2722348CNV Deletion23290073
    nsv179909CNV Loss16902084
    nsv833959CNV Loss17160897
    nsv179907CNV Loss16902084
    nsv833957CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603108    OMIM disorders: --

    18 diseases for MAPRE1:    About MalaCards
    gardner syndrome    pediatric ependymoma    colorectal cancer    familial adenomatous polyposis
    ependymoma    was-related disorders    esophageal squamous cell carcinoma    acute lymphoblastic leukemia
    lymphoblastic leukemia    esophagitis    squamous cell carcinoma    gastric cancer
    obesity    hepatocellular carcinoma    leukemia    alzheimer's disease
    breast cancer    neuronitis


    MAPRE1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for MAPRE1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    familial adenomatous polyposis 83.8 11 10226031 (1), 10773885 (1), 9624007 (1), 11206549 (1) (see all 11)
    colorectal cancer 24.5 3 9823979 (2), 19928351 (1)
    chromosomal aberrations 6.44 1 15751040 (1)
    tumors 2.75 11 16007168 (2), 10226031 (1), 10346819 (1), 15616574 (1) (see all 8)

    Genetic Association Database (GAD): MAPRE1
    Human Genome Epidemiology (HuGE) Navigator: MAPRE1 (1 document)

    Export disorders for MAPRE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPRE1 gene, integrated from 9 sources (see all 128):
    (articles sorted by number of sources associating them with MAPRE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. APC binds to the novel protein EB1. (PubMed id 7606712)1, 2, 3, 9 Su L.-K.... Kinzler K.W. (1995)
    2. The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules. (PubMed id 9724749)1, 2, 3 Berrueta L.... Bierer B.E. (1998)
    3. Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome. (PubMed id 12388762)1, 2, 9 Askham J.M.... Morrison E.E. (2002)
    4. Crystal structure of the amino-terminal microtubule-binding domain of end-binding protein 1 (EB1). (PubMed id 12857735)1, 2, 9 Hayashi I. and Ikura M. (2003)
    5. The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain. (PubMed id 10226031)1, 2, 9 Berrueta L.... Bierer B.E. (1999)
    6. TIP150 interacts with and targets MCAK at the microtubule plus ends. (PubMed id 19543227)1, 2, 9 Jiang K....Yao X. (2009)
    7. Structural insights into the EB1-APC interaction. (PubMed id 15616574)1, 2, 9 Honnappa S.... Steinmetz M.O. (2005)
    8. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    9. Mammalian end binding proteins control persistent microtubule growth. (PubMed id 19255245)1, 2 Komarova Y....Akhmanova A. (2009)
    10. An EB1-binding motif acts as a microtubule tip locali zation signal. (PubMed id 19632184)1, 2 Honnappa S....Steinmetz M.O. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22919 HGNC: 6890 AceView: MAPRE1 Ensembl:ENSG00000101367 euGenes: HUgn22919
    ECgene: MAPRE1 H-InvDB: MAPRE1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPRE1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPRE1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAPRE1 gene:
    Search GeneIP for patents involving MAPRE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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