Aliases for MAPRE1 Gene
External Ids for MAPRE1 Gene
The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAPRE1 Gene
MAPRE1 (Microtubule-Associated Protein, RP/EB Family, Member 1) is a Protein Coding gene. Diseases associated with MAPRE1 include colorectal cancer and adenomatous polyposis coli. Among its related pathways are PAK Pathway and Cell Cycle, Mitotic. GO annotations related to this gene include protein C-terminus binding and microtubule plus-end binding. An important paralog of this gene is MAPRE2.
UniProtKB/Swiss-Prot for MAPRE1 Gene
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.