Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MAPKBP1 Gene

protein-coding   GIFtS: 51
GCID: GC15P042067

Mitogen-Activated Protein Kinase Binding Protein 1

(Previous name: mitogen activated protein kinase binding protein 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Mitogen-Activated Protein Kinase Binding Protein 11 2     Mitogen-Activated Protein Kinase-Binding Protein 12
Mitogen Activated Protein Kinase Binding Protein 11 2     JNKBP13
JNKBP-12 3     KIAA05963
JNK-Binding Protein 12 3     

External Ids:    HGNC: 295361   Entrez Gene: 230052   Ensembl: ENSG000001378027   UniProtKB: O603363   

Export aliases for MAPKBP1 gene to outside databases

Previous GC identifers: GC15P037434 GC15P034962 GC15P039645 GC15P039782 GC15P039855 GC15P018915


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for MAPKBP1 Gene:
MAPKBP1 (mitogen-activated protein kinase binding protein 1) is a protein-coding gene. Diseases associated with MAPKBP1 include microcephaly, and ataxia. An important paralog of this gene is WDR62.

UniProtKB/Swiss-Prot: MABP1_HUMAN, O60336
Function: Involved in JNK signaling pathway (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPKBP1 gene promoter:
         Nkx3-1   HFH-3   Brachyury   SREBP-1c   SREBP-1b   Evi-1   AREB6   FOXI1   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAPKBP1 promoter sequence
   Search Chromatin IP Primers for MAPKBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPKBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.1   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q15.1

MAPKBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPKBP1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P042067:  view genomic region     (about GC identifiers)

Start:
42,066,632 bp from pter      End:
42,120,053 bp from pter
Size:
53,422 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MABP1_HUMAN, O60336 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase-binding protein 1  
Size: 1514 amino acids; 163818 Da
Subunit: Interacts with MAPK10 (By similarity)
Sequence caution: Sequence=BAA25522.2; Type=Erroneous initiation;
Secondary accessions: A6NM93 A8K8P9 Q14CB5 Q14CD8 Q49AJ8 Q5W9G9
Alternative splicing: 6 isoforms:  O60336-1   O60336-2   O60336-3   O60336-4   O60336-5   O60336-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAPKBP1: NX_O60336

Explore proteomics data for MAPKBP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MAPKBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001122080.1  NP_001252540.1  NP_055809.2  

    ENSEMBL proteins: 
     ENSP00000427582   ENSP00000397570   ENSP00000421891   ENSP00000393099   ENSP00000426154  
     ENSP00000422132   ENSP00000221214   ENSP00000260357  

    MAPKBP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MAPKBP1
    GenScript Custom Purified and Recombinant Proteins Services for MAPKBP1
    Novus Biologicals MAPKBP1 Protein
    Novus Biologicals MAPKBP1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAPKBP1

    MAPKBP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MAPKBP1
    Novus Biologicals MAPKBP1 Antibodies
    Abcam antibodies for MAPKBP1
    Cloud-Clone Corp. Antibodies for MAPKBP1
    Search ThermoFisher Antibodies for MAPKBP1
    LSBio Antibodies in human, mouse, rat for MAPKBP1

    MAPKBP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAPKBP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAPKBP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAPKBP1
    Cloud-Clone Corp. CLIAs for MAPKBP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry O60336

    ProtoNet protein and cluster: O60336

    UniProtKB/Swiss-Prot: MABP1_HUMAN, O60336
    Similarity: Contains 12 WD repeats


    MAPKBP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MABP1_HUMAN, O60336
    Function: Involved in JNK signaling pathway (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003743translation initiation factor activity ----
    GO:0005515protein binding ----
         
    MAPKBP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MAPKBP1:
     Decreased viability of wild-ty 

         1 MGI phenotypic allele for Mapkbp1 (no phenotypes)

    MAPKBP1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAPKBP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAPKBP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPKBP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPKBP1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MAPKBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPKBP1 (see all 53):
    hsa-miR-607 hsa-miR-3194-5p hsa-miR-485-3p hsa-miR-29a hsa-miR-3138 hsa-miR-486-3p hsa-miR-650 hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidMAPKBP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAPKBP1
    Predesigned siRNA for gene silencing in human, mouse, rat MAPKBP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAPKBP1

    Clone
    Products:
         
    OriGene clones in human, mouse for MAPKBP1 (see all 11)
    OriGene ORF clones in mouse, rat for MAPKBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MAPKBP1 (NM_014994)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPKBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPKBP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAPKBP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAPKBP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPKBP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAPKBP1
    Interactions:

        Search GeneGlobe Interaction Network for MAPKBP1

    Selected Interacting proteins for MAPKBP1 (O603362, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APTXQ7Z2E32, 3MINT-2870118 I2D: score=3 
    MAPK10P537793I2D: score=3 
    MAPK9P459843I2D: score=3 
    MAPK8P459833I2D: score=2 
    MAP3K7O433183I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007256activation of JNKK activity ----

    MAPKBP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAPKBP1 (MABP1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MAPKBP1 gene (3 alternative transcripts): 
    NM_001128608.1  NM_001265611.1  NM_014994.2  

    Unigene Cluster for MAPKBP1:

    Mitogen-activated protein kinase binding protein 1
    Hs.513661  [show with all ESTs]
    Unigene Representative Sequence: NM_001128608
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512970 ENST00000457542(uc001zok.4 uc001zoj.4 uc010bcj.3 uc010bci.3 uc010udb.2 uc010bck.3 uc010bcl.3)
    ENST00000505373 ENST00000456763 ENST00000514566 ENST00000502292 ENST00000510535
    ENST00000505061 ENST00000507762 ENST00000515164 ENST00000507147 ENST00000503526
    ENST00000508050 ENST00000506301 ENST00000502695 ENST00000512433 ENST00000221214
    ENST00000260357
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MAPKBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPKBP1 (see all 53):
    hsa-miR-607 hsa-miR-3194-5p hsa-miR-485-3p hsa-miR-29a hsa-miR-3138 hsa-miR-486-3p hsa-miR-650 hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidMAPKBP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MAPKBP1
    Predesigned siRNA for gene silencing in human, mouse, rat MAPKBP1
    Clone
    Products:
         
    OriGene clones in human, mouse for MAPKBP1 (see all 11)
    OriGene ORF clones in mouse, rat for MAPKBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MAPKBP1 (NM_014994)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPKBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPKBP1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPKBP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPKBP1
      QuantiTect SYBR Green Assays in human, mouse, rat MAPKBP1
      QuantiFast Probe-based Assays in human, mouse, rat MAPKBP1

    Additional mRNA sequence: 

    AB011168.2 AB177850.1 AK091616.1 AK292414.1 AK302482.1 AL833267.1 AL834413.1 BC111090.1 
    BC113983.1 BC114493.1 BX648786.1 NR_049761.1 NR_049762.1 

    19 DOTS entries:

    DT.100814991  DT.409769  DT.97836514  DT.95366070  DT.411781  DT.97767632  DT.100711128  DT.100036105 
    DT.102823467  DT.75117545  DT.91663210  DT.100814990  DT.95366069  DT.121073181  DT.70100075  DT.91714025 
    DT.97783563  DT.100036106  DT.91653804 

    Selected AceView cDNA sequences (see all 91):

    AI368862 BQ959299 AL046558 CK904274 CR609233 BM476443 AB011168 AI871091 
    BQ045172 BX648786 D80617 AI674759 AL833267 BM810533 BX640787 CO245500 
    AK091616 BQ072196 BE890024 BM559468 AA321864 BQ961394 BM555830 AI041286 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAPKBP1 (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19 ^ 20a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                -           -     -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20b ^ 21a · 21b ^ 22a · 22b · 22c · 22d ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29
    SP1:                                                                                                      
    SP2:                                                                                                      
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for MAPKBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MAPKBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCGGGGGC
    MAPKBP1 Expression
    About this image


    MAPKBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Brain (Nervous System)
             Medulla Oblongata
     
     Spinal Cord (Nervous System)
    MAPKBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPKBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513661
        Custom PCR Arrays for MAPKBP1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPKBP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPKBP1
    QuantiTect SYBR Green Assays in human, mouse, rat MAPKBP1
    QuantiFast Probe-based Assays in human, mouse, rat MAPKBP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPKBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MAPKBP1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapkbp11 , 5 mitogen-activated protein kinase binding protein 11, 5 85.5(n)1
    86.28(a)1
      2 (60.03 cM)5
    263901  NM_011941.31  NP_036071.31 
     1199726995 
    chicken
    (Gallus gallus)
    Aves MAPKBP11 mitogen-activated protein kinase binding protein 1 67.09(n)
    69.68(a)
      771487  XM_004941643.1  XP_004941700.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAPKBP16
    mitogen-activated protein kinase binding protein 1...
    65(a)
    1 ↔ 1
    1(40873601-40927600)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mapkbp11 mitogen-activated protein kinase binding protein 1 62.93(n)
    63.65(a)
      100495737  XM_002933721.2  XP_002933767.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005353861 mitogen-activated protein kinase-binding protein 1-like 66.59(n)
    67.46(a)
      100535386  XM_003200317.2  XP_003200365.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73376
    --
    18(a)
    1 → many
    2L(1884622-1944289)
    worm
    (Caenorhabditis elegans)
    Secernentea H24G06.11 H24G06.1 40.15(n)
    31.7(a)
      179326  NM_073041.2  NP_505442.2 


    ENSEMBL Gene Tree for MAPKBP1 (if available)
    TreeFam Gene Tree for MAPKBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MAPKBP1 gene
    WDR622  
    1 SIMAP similar gene for MAPKBP1 using alignment to 7 protein entries:     MABP1_HUMAN (see all proteins):
    WDR62

    MAPKBP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MAPKBP1 (see all 1146)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs359239961,2
    C--18931857(+) AAAAC-/AG/GA 
            
    ATCTT
    5 -- int10--------
    rs1870473841,2
    --42064694(+) GTGGCA/GCGTGC 5 -- us2k10--------
    rs1444405321,2
    --42064708(+) TAATCC/TCAGCT 5 -- us2k10--------
    rs1898434671,2
    --42064781(+) GATCGC/TCACTG 5 -- us2k10--------
    rs680257531,2
    C--42064832(+) AAAAA-/AAA   
      AAAAAA
    AAAAA
    8 -- us2k1 cds11Minor allele frequency- AAAAAAAAA:0.00NA 2
    rs569428101,2
    F--42065017(+) ATGATC/TTGGAG 5 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1459646371,2
    C--42065035(+) GGGACA/GGCTCT 5 -- us2k10--------
    rs1398805381,2
    --42065215(+) GTAGCC/TAATGG 5 -- us2k10--------
    rs1164877771,2
    F--42065220(+) TAATGG/CTTCTT 5 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1825202861,2
    --42065230(+) TGCCTC/TCTTCT 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAPKBP1 (42066632 - 42120053 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAPKBP1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663912CNV Deletion23128226
    esv1008860CNV Deletion20482838
    nsv1506CNV Insertion18451855
    nsv904115CNV Loss21882294
    nsv517631CNV Loss19592680
    dgv2365n71CNV Loss21882294
    dgv2364n71CNV Loss21882294
    nsv904119CNV Loss21882294
    nsv904116CNV Loss21882294
    nsv9244CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAPKBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPKBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    2 diseases for MAPKBP1:    
    About MalaCards
    microcephaly    ataxia

    1 disease from the University of Copenhagen DISEASES database for MAPKBP1:
    Microcephaly

    MAPKBP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MAPKBP1
    Human Genome Epidemiology (HuGE) Navigator: MAPKBP1 (4 documents)

    Export disorders for MAPKBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MAPKBP1 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with MAPKBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (DNA Res. 1998)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Alternative splice variants encoding unstable protein domains exist in the human brain. (PubMed id 15491607)1, 2 Homma K.... Nishikawa K. (J. Mol. Biol. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1. (PubMed id 10471813)1, 3 Koyano S....Yoshioka K. (FEBS Lett. 1999)
    6. Identification and analysis of a novel dimerization domain shared by various members of c-Jun N-terminal kinase (JNK) scaffold proteins. (PubMed id 23341463)1 Cohen-Katsenelson K....Aronheim A. (J. Biol. Chem. 2013)
    7. The c-Jun N-terminal kinase (JNK)-binding protein (JNKBP1) acts as a negative regulator of NOD2 protein signaling by inhibiting its oligomerization process. (PubMed id 22700971)1 Lecat A....Legrand-Poels S. (J. Biol. Chem. 2012)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    10. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23005 HGNC: 29536 AceView: MAPKBP1 Ensembl:ENSG00000137802 euGenes: HUgn23005
    ECgene: MAPKBP1 H-InvDB: MAPKBP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0596

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MAPKBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MAPKBP1 gene:
    Search GeneIP for patents involving MAPKBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MAPKBP1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MAPKBP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for MAPKBP1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MAPKBP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MAPKBP1   OriGene Custom Protein Services for MAPKBP1  

     
     
     Block miRNA regulation of human, mouse, rat MAPKBP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MAPKBP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPKBP1 Predesigned siRNA for gene silencing in human, mouse, rat MAPKBP1
     QuantiFast Probe-based Assays in human, mouse, rat MAPKBP1 QuantiTect SYBR Green Assays in human, mouse, rat MAPKBP1
     Custom PCR Arrays for MAPKBP1 Search Chromatin IP Primers for MAPKBP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPKBP1  Search GeneGlobe Interaction Network for MAPKBP1
     Regulatory tfbs in MAPKBP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MAPKBP1 GenScript cDNA clones with any tag delivered in your preferred vector for MAPKBP1
     GenScript Custom Assay Services for MAPKBP1 GenScript Custom overexpressing Cell Line Services for MAPKBP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MAPKBP1 (MABP1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MAPKBP1 antibodies
     MAPKBP1 proteins
     MAPKBP1 lysates
     Antibodies for MAPKBP1
     See all of Abcam's Antibodies, Kits and Proteins for MAPKBP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MAPKBP1
     Antibodies for MAPKBP1
     ELISAs for MAPKBP1
     CLIAs for MAPKBP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for MAPKBP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPKBP1
     SwitchGear 3'UTR luciferase reporter plasmids for MAPKBP1
     SwitchGear Promoter luciferase reporter plasmids for MAPKBP1
     Search ThermoFisher Antibodies for MAPKBP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPKBP1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAPKBP1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAPKBP1
     LSBio Antibodies in human, mouse, rat for MAPKBP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MAPKBP1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4