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Aliases for MAPKBP1 Gene

Aliases for MAPKBP1 Gene

  • Mitogen-Activated Protein Kinase Binding Protein 1 2 3
  • Mitogen Activated Protein Kinase Binding Protein 1 2 3
  • JNK-Binding Protein 1 3 4
  • JNKBP-1 3 4
  • KIAA0596 4
  • JNKBP1 4

External Ids for MAPKBP1 Gene

Previous GeneCards Identifiers for MAPKBP1 Gene

  • GC15P037434
  • GC15P034962
  • GC15P039645
  • GC15P039782
  • GC15P039855
  • GC15P042067
  • GC15P018915

Summaries for MAPKBP1 Gene

GeneCards Summary for MAPKBP1 Gene

MAPKBP1 (Mitogen-Activated Protein Kinase Binding Protein 1) is a Protein Coding gene. An important paralog of this gene is WDR62.

UniProtKB/Swiss-Prot for MAPKBP1 Gene

  • Involved in JNK signaling pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPKBP1 Gene

Genomics for MAPKBP1 Gene

Regulatory Elements for MAPKBP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAPKBP1 Gene

Chromosome:
15
Start:
41,774,434 bp from pter
End:
41,827,855 bp from pter
Size:
53,422 bases
Orientation:
Plus strand

Genomic View for MAPKBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAPKBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPKBP1 Gene

Proteins for MAPKBP1 Gene

  • Protein details for MAPKBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60336-MABP1_HUMAN
    Recommended name:
    Mitogen-activated protein kinase-binding protein 1
    Protein Accession:
    O60336
    Secondary Accessions:
    • A6NM93
    • A8K8P9
    • Q14CB5
    • Q14CD8
    • Q49AJ8
    • Q5W9G9

    Protein attributes for MAPKBP1 Gene

    Size:
    1514 amino acids
    Molecular mass:
    163818 Da
    Quaternary structure:
    • Interacts with MAPK10.
    SequenceCaution:
    • Sequence=BAA25522.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAPKBP1 Gene

neXtProt entry for MAPKBP1 Gene

Proteomics data for MAPKBP1 Gene at MOPED

Post-translational modifications for MAPKBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for MAPKBP1 Gene

Domains & Families for MAPKBP1 Gene

Gene Families for MAPKBP1 Gene

Protein Domains for MAPKBP1 Gene

Suggested Antigen Peptide Sequences for MAPKBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60336

UniProtKB/Swiss-Prot:

MABP1_HUMAN :
  • Contains 12 WD repeats.
Similarity:
  • Contains 12 WD repeats.
genes like me logo Genes that share domains with MAPKBP1: view

Function for MAPKBP1 Gene

Molecular function for MAPKBP1 Gene

UniProtKB/Swiss-Prot Function:
Involved in JNK signaling pathway.

Gene Ontology (GO) - Molecular Function for MAPKBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MAPKBP1: view
genes like me logo Genes that share phenotypes with MAPKBP1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAPKBP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MAPKBP1 Gene

Localization for MAPKBP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPKBP1 Gene COMPARTMENTS Subcellular localization image for MAPKBP1 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for MAPKBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with MAPKBP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAPKBP1 Gene

Pathways & Interactions for MAPKBP1 Gene

SuperPathways for MAPKBP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAPKBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007256 activation of JNKK activity IEA --
genes like me logo Genes that share ontologies with MAPKBP1: view

No data available for Pathways by source and SIGNOR curated interactions for MAPKBP1 Gene

Drugs & Compounds for MAPKBP1 Gene

No Compound Related Data Available

Transcripts for MAPKBP1 Gene

Unigene Clusters for MAPKBP1 Gene

Mitogen-activated protein kinase binding protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAPKBP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPKBP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19 ^ 20a ·
SP1:
SP2: - - -
SP3:
SP4:
SP5:
SP6:
SP7: - - -
SP8:
SP9:
SP10: -
SP11:
SP12: - -
SP13:

ExUns: 20b ^ 21a · 21b ^ 22a · 22b · 22c · 22d ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MAPKBP1 Gene

GeneLoc Exon Structure for
MAPKBP1
ECgene alternative splicing isoforms for
MAPKBP1

Expression for MAPKBP1 Gene

mRNA expression in normal human tissues for MAPKBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPKBP1 Gene

This gene is overexpressed in Brain - Cerebellum (x5.4) and Brain - Cerebellar Hemisphere (x4.7).

Protein differential expression in normal tissues from HIPED for MAPKBP1 Gene

This gene is overexpressed in Cervix (56.2) and Testis (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPKBP1 Gene



SOURCE GeneReport for Unigene cluster for MAPKBP1 Gene Hs.513661

genes like me logo Genes that share expression patterns with MAPKBP1: view

Protein tissue co-expression partners for MAPKBP1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MAPKBP1 Gene

Orthologs for MAPKBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAPKBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAPKBP1 35
  • 88.84 (n)
  • 90.35 (a)
MAPKBP1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPKBP1 35
  • 89.08 (n)
  • 91.66 (a)
MAPKBP1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapkbp1 35
  • 85.5 (n)
  • 86.28 (a)
Mapkbp1 16
Mapkbp1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAPKBP1 35
  • 99.1 (n)
  • 98.97 (a)
rat
(Rattus norvegicus)
Mammalia Mapkbp1 35
  • 85.06 (n)
  • 86.72 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MAPKBP1 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAPKBP1 35
  • 67.09 (n)
  • 69.68 (a)
MAPKBP1 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPKBP1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapkbp1 35
  • 62.93 (n)
  • 63.65 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100535386 35
  • 66.59 (n)
  • 67.46 (a)
MAPKBP1 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7337 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea H24G06.1 35
  • 40.15 (n)
  • 31.7 (a)
H24G06.1 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for MAPKBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPKBP1 Gene

ENSEMBL:
Gene Tree for MAPKBP1 (if available)
TreeFam:
Gene Tree for MAPKBP1 (if available)

Paralogs for MAPKBP1 Gene

Paralogs for MAPKBP1 Gene

(1) SIMAP similar genes for MAPKBP1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MAPKBP1: view

Variants for MAPKBP1 Gene

Sequence variations from dbSNP and Humsavar for MAPKBP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs890497 -- 41,819,735(-) CAGTA(C/T)CCTAC intron-variant
rs890498 -- 41,819,100(-) AGGCT(C/G)ACATC intron-variant
rs919142 -- 41,804,974(+) GTCTC(A/C)CTGCT intron-variant
rs1061010 -- 41,825,892(-) GTGCA(A/G)GTAGA utr-variant-3-prime, nc-transcript-variant
rs1081022 -- 41,782,925(+) TATCC(G/T)TACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPKBP1 Gene

Variant ID Type Subtype PubMed ID
dgv740e1 CNV Complex 17122850
dgv2363n71 CNV Gain 21882294
esv2663912 CNV Deletion 23128226
nsv904115 CNV Loss 21882294
nsv904116 CNV Loss 21882294
nsv517631 CNV Loss 19592680
nsv9243 CNV Gain 18304495
dgv2364n71 CNV Loss 21882294
nsv904119 CNV Loss 21882294
dgv2365n71 CNV Loss 21882294
nsv9244 CNV Gain 18304495
esv1008860 CNV Deletion 20482838
nsv1506 CNV Insertion 18451855

Variation tolerance for MAPKBP1 Gene

Residual Variation Intolerance Score: 68.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.81; 89.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPKBP1 Gene

HapMap Linkage Disequilibrium report
MAPKBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPKBP1 Gene

Disorders for MAPKBP1 Gene

Relevant External Links for MAPKBP1

Genetic Association Database (GAD)
MAPKBP1
Human Genome Epidemiology (HuGE) Navigator
MAPKBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPKBP1
genes like me logo Genes that share disorders with MAPKBP1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAPKBP1 Gene

Publications for MAPKBP1 Gene

  1. A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1. (PMID: 10471813) Koyano S. … Yoshioka K. (FEBS Lett. 1999) 2 67
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67
  5. Identification and analysis of a novel dimerization domain shared by various members of c-Jun N-terminal kinase (JNK) scaffold proteins. (PMID: 23341463) Cohen-Katsenelson K. … Aronheim A. (J. Biol. Chem. 2013) 67

Products for MAPKBP1 Gene

Sources for MAPKBP1 Gene

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