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Aliases for MAPKBP1 Gene

Aliases for MAPKBP1 Gene

  • Mitogen-Activated Protein Kinase Binding Protein 1 2 3 5
  • JNK-Binding Protein 1 3 4
  • JNKBP-1 3 4
  • JNKBP1 3 4
  • Mitogen Activated Protein Kinase Binding Protein 1 2
  • Mitogen-Activated Protein Kinase-Binding Protein 1 3
  • KIAA0596 4

External Ids for MAPKBP1 Gene

Previous GeneCards Identifiers for MAPKBP1 Gene

  • GC15P037434
  • GC15P034962
  • GC15P039645
  • GC15P039782
  • GC15P039855
  • GC15P042067
  • GC15P018915

Summaries for MAPKBP1 Gene

GeneCards Summary for MAPKBP1 Gene

MAPKBP1 (Mitogen-Activated Protein Kinase Binding Protein 1) is a Protein Coding gene. An important paralog of this gene is WDR62.

UniProtKB/Swiss-Prot for MAPKBP1 Gene

  • Involved in JNK signaling pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPKBP1 Gene

Genomics for MAPKBP1 Gene

Regulatory Elements for MAPKBP1 Gene

Enhancers for MAPKBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F042056 1.7 FANTOM5 Ensembl ENCODE 11.6 +283.2 283225 2.0 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF48 BRCA1 GLIS2 ZNF143 FOS CDAN1 MAPKBP1 PLA2G4D PLA2G4E ENSG00000260814 LRRC57 EHD4 MGA SNAP23 TMEM87A
GH15F041800 0.9 Ensembl ENCODE 21.1 +29.8 29827 7.0 ZNF263 CTCF TFAP4 CBX3 ZNF146 NFIA NFYC MNT ZIC2 RAD21 JMJD7 MAPKBP1 JMJD7-PLA2G4B ENSG00000250379 PLA2G4B LOC105370792 SPTBN5 TYRO3 RPAP1 RNU6-1169P
GH15F041925 1.7 FANTOM5 Ensembl ENCODE 10.9 +162.4 162392 23.4 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 BRCA1 YY1 GATA2 ZNF143 SPTBN5 EHD4 LOC105370792 LTK JMJD7 PLA2G4E-AS1 ENSG00000250379 JMJD7-PLA2G4B MAPKBP1 PLA2G4E
GH15F041811 1 Ensembl ENCODE 18.4 +37.1 37068 0.6 GTF2F1 CTCF ARID4B MAX RAD21 RFX5 ZNF143 SMC3 ZNF600 DEK MAPKBP1 JMJD7 RNU6-1169P GC15P041819 ENSG00000279937
GH15F041492 1.5 FANTOM5 ENCODE 11.6 -279.6 -279615 5.1 ZFP64 ARID4B DMAP1 ZNF2 YY1 SLC30A9 KLF13 ZNF263 SP3 SP5 NDUFAF1 RTF1 RAD51-AS1 RPAP1 ENSG00000260814 MAPKBP1 TYRO3 RNU6-1169P RPUSD2 ITPKA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAPKBP1 on UCSC Golden Path with GeneCards custom track

Promoters for MAPKBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001451687 166 1601 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 ZNF143
ENSR00001794322 1466 201 ARID1B OSR2 SMARCA4 HLF CEBPB MAX

Genomic Location for MAPKBP1 Gene

41,774,434 bp from pter
41,827,855 bp from pter
53,422 bases
Plus strand

Genomic View for MAPKBP1 Gene

Genes around MAPKBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPKBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPKBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPKBP1 Gene

Proteins for MAPKBP1 Gene

  • Protein details for MAPKBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitogen-activated protein kinase-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • A6NM93
    • A8K8P9
    • Q14CB5
    • Q14CD8
    • Q49AJ8
    • Q5W9G9

    Protein attributes for MAPKBP1 Gene

    1514 amino acids
    Molecular mass:
    163818 Da
    Quaternary structure:
    • Interacts with MAPK10.
    • Sequence=BAA25522.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAPKBP1 Gene

neXtProt entry for MAPKBP1 Gene

Post-translational modifications for MAPKBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for MAPKBP1
  • Santa Cruz Biotechnology (SCBT) Antibodies for MAPKBP1

No data available for DME Specific Peptides for MAPKBP1 Gene

Domains & Families for MAPKBP1 Gene

Gene Families for MAPKBP1 Gene

Protein Domains for MAPKBP1 Gene

Suggested Antigen Peptide Sequences for MAPKBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 12 WD repeats.
  • Contains 12 WD repeats.
genes like me logo Genes that share domains with MAPKBP1: view

Function for MAPKBP1 Gene

Molecular function for MAPKBP1 Gene

UniProtKB/Swiss-Prot Function:
Involved in JNK signaling pathway.

Gene Ontology (GO) - Molecular Function for MAPKBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MAPKBP1: view
genes like me logo Genes that share phenotypes with MAPKBP1: view

Animal Models for MAPKBP1 Gene

MGI Knock Outs for MAPKBP1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPKBP1 Gene

Localization for MAPKBP1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPKBP1 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAPKBP1 Gene

Pathways & Interactions for MAPKBP1 Gene

SuperPathways for MAPKBP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAPKBP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for MAPKBP1 Gene

Transcripts for MAPKBP1 Gene

Unigene Clusters for MAPKBP1 Gene

Mitogen-activated protein kinase binding protein 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPKBP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19 ^ 20a ·
SP2: - - -
SP7: - - -
SP10: -
SP12: - -

ExUns: 20b ^ 21a · 21b ^ 22a · 22b · 22c · 22d ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29

Relevant External Links for MAPKBP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAPKBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAPKBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPKBP1 Gene

This gene is overexpressed in Brain - Cerebellum (x5.4) and Brain - Cerebellar Hemisphere (x4.7).

Protein differential expression in normal tissues from HIPED for MAPKBP1 Gene

This gene is overexpressed in Cervix (56.2) and Testis (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAPKBP1 Gene

Protein tissue co-expression partners for MAPKBP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAPKBP1 Gene:


SOURCE GeneReport for Unigene cluster for MAPKBP1 Gene:

genes like me logo Genes that share expression patterns with MAPKBP1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MAPKBP1 Gene

Orthologs for MAPKBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAPKBP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAPKBP1 34
  • 99.1 (n)
(Canis familiaris)
Mammalia MAPKBP1 34 35
  • 89.08 (n)
(Bos Taurus)
Mammalia MAPKBP1 34 35
  • 88.84 (n)
(Ornithorhynchus anatinus)
Mammalia MAPKBP1 35
  • 87 (a)
(Mus musculus)
Mammalia Mapkbp1 34 16 35
  • 85.5 (n)
(Rattus norvegicus)
Mammalia Mapkbp1 34
  • 85.06 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 74 (a)
-- 35
  • 68 (a)
(Gallus gallus)
Aves MAPKBP1 34 35
  • 67.09 (n)
(Anolis carolinensis)
Reptilia MAPKBP1 35
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mapkbp1 34
  • 62.93 (n)
(Danio rerio)
Actinopterygii LOC100535386 34
  • 66.59 (n)
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7337 35
  • 18 (a)
(Caenorhabditis elegans)
Secernentea H24G06.1 34 35
  • 40.15 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
Species where no ortholog for MAPKBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPKBP1 Gene

Gene Tree for MAPKBP1 (if available)
Gene Tree for MAPKBP1 (if available)

Paralogs for MAPKBP1 Gene

Paralogs for MAPKBP1 Gene

(1) SIMAP similar genes for MAPKBP1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MAPKBP1: view

Variants for MAPKBP1 Gene

Sequence variations from dbSNP and Humsavar for MAPKBP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1043627 -- 41,827,702(-) AAACA(A/G)GGCGG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1061010 -- 41,825,892(-) GTGCA(A/G)GTAGA nc-transcript-variant, utr-variant-3-prime
rs10629541 -- 41,782,275(+) TCTCA(-/AA/AAA)AAAAA intron-variant
rs10634609 -- 41,827,126(+) CCTGT(-/CT/TC)CTACT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1081022 -- 41,782,925(+) TATCC(G/T)TACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPKBP1 Gene

Variant ID Type Subtype PubMed ID
dgv2581n100 CNV gain 25217958
dgv2582n100 CNV gain 25217958
dgv449e214 CNV gain 21293372
esv1008860 CNV deletion 20482838
esv2663912 CNV deletion 23128226
esv2760027 CNV loss 17122850
esv3636248 CNV loss 21293372
esv3636249 CNV loss 21293372
esv3636250 CNV loss 21293372
nsv1035998 CNV gain 25217958
nsv1038894 CNV gain 25217958
nsv1049514 CNV gain 25217958
nsv1134437 CNV deletion 24896259
nsv1506 CNV insertion 18451855
nsv517631 CNV loss 19592680
nsv9243 CNV gain 18304495
nsv9244 CNV gain 18304495
nsv952613 CNV deletion 24416366

Variation tolerance for MAPKBP1 Gene

Residual Variation Intolerance Score: 68.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.81; 89.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPKBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPKBP1 Gene

Disorders for MAPKBP1 Gene

Relevant External Links for MAPKBP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MAPKBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAPKBP1 Gene

Publications for MAPKBP1 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Alternative splice variants encoding unstable protein domains exist in the human brain. (PMID: 15491607) Homma K. … Nishikawa K. (J. Mol. Biol. 2004) 3 4 64
  5. A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1. (PMID: 10471813) Koyano S. … Yoshioka K. (FEBS Lett. 1999) 2 3 64

Products for MAPKBP1 Gene

Sources for MAPKBP1 Gene

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