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MAPKAPK5-AS1 Gene

RNA gene   GIFtS: 23
GCID: GC12M112279

MAPKAPK5 Antisense RNA 1

(Previous names: chromosome 12 open reading frame 47, MAPKAPK5 antisense...)
(Previous symbol: C12orf47)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): antisense

Quality score for this RNA gene is 3

Aliases
MAPKAPK5 Antisense RNA 11 2 3
C12orf471 2 3
Chromosome 12 Open Reading Frame 471
MAPKAPK5 Antisense RNA 1 (Non-Protein Coding)1
MAPKAPK5 Antisense Gene Protein 13

External Ids:    HGNC: 240911   Entrez Gene: 512752   Ensembl: ENSG000002346087   UniProtKB: Q8N8E13   
ORGUL members:         

Export aliases for MAPKAPK5-AS1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MAPKAPK5-AS1 Gene:
MAPKAPK5-AS1 (MAPKAPK5 antisense RNA 1) is an RNA gene, and is affiliated with the antisense RNA class.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MAPKAPK5-AS1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MAPKAPK5-AS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPKAPK5-AS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.12   Ensembl cytogenetic band:  12q24.12   HGNC cytogenetic band: 12q24.12

MAPKAPK5-AS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPKAPK5-AS1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M112279:  view genomic region     (about GC identifiers)

Start:
112,277,571 bp from pter      End:
112,280,706 bp from pter
Size:
3,136 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MAPKAPK5-AS1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MAAS1_HUMAN, Q8N8E1 (See protein sequence)
Recommended Name: Putative uncharacterized protein encoded by MAPKAPK5-AS1  
Size: 139 amino acids; 13175 Da
Caution: Product of a dubious CDS prediction

Explore the universe of human proteins at neXtProt for MAPKAPK5-AS1: NX_Q8N8E1

Explore proteomics data for MAPKAPK5-AS1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MAPKAPK5-AS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LNCRNA: Long non-coding RNAs

    ProtoNet protein and cluster: Q8N8E1


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MAPKAPK5-AS1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAPKAPK5-AS1
    Interactions:

        Search GeneGlobe Interaction Network for MAPKAPK5-AS1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MAPKAPK5-AS1 (MAAS1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAPKAPK5-AS1 gene: 
    NM_016534.2  

    Unigene Cluster for MAPKAPK5-AS1:

    MAPKAPK5 antisense RNA 1
    Hs.333120  [show with all ESTs]
    Unigene Representative Sequence: AK096935
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000443596(lincRNA) ENST00000456429(lincRNA)(uc001tsw.2 uc001tsx.2) ENST00000428207(lincRNA)(uc001tsv.2 uc001tsy.2)
    ENST00000442119(lincRNA)(uc001tsu.1) ENST00000590479(lincRNA) ENST00000609228(lincRNA) ENST00000609983(lincRNA)

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    Additional mRNA sequence: 

    AK096935.1 AK124158.1 BC007973.2 BC015633.2 BC023547.2 BC032560.1 BC071748.1 BC071984.1 
    BC107695.1 BC136540.1 NR_015404.1 

    10 DOTS entries:

    DT.101981945  DT.100787424  DT.215279  DT.100787425  DT.316676  DT.100730501  DT.316677  DT.40133227 
    DT.97841896  DT.95171417 

    Selected AceView cDNA sequences (see all 164):

    BE079549 AA233166 AA815207 BE298160 AK096935 BU683052 CB130940 BG939350 
    BC007973 BQ018566 CB154504 H92193 AA830938 AI660185 BC071748 BI829025 
    BM970651 BQ576337 BM829240 BM782061 CD365443 BC023547 BE694064 AI913954 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    Expression evidence for MAPKAPK5-AS1:none

    MAPKAPK5-AS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MAPKAPK5-AS1 Expression
    About this image

    MAPKAPK5-AS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPKAPK5-AS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.333120
        Custom PCR Arrays for MAPKAPK5-AS1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    ENSEMBL Gene Tree for MAPKAPK5-AS1 (if available)
    TreeFam Gene Tree for MAPKAPK5-AS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAPKAPK5-AS1 (see all 23)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs123707701,2
    C,F,H--112277084(+) tccgcC/Ttcaaa 1 -- ds500110Minor allele frequency- T:0.03NS EA NA 1000
    rs1442667681,2
    --112277207(+) AGTTGA/CACAGC 1 -- ds50010--------
    rs762419011,2
    C,F--112277227(+) AGCTGC/TTTGAG 1 -- ds50011Minor allele frequency- T:0.02NA 120
    rs64898101,2
    C,F,A,H--112277406(+) CATTAC/TTTTTA 1 -- ds500111Minor allele frequency- T:0.49NA WA CSA EA 375
    rs1400403721,2
    C--112277501(+) TTCATC/TGCGGG 1 -- ds50010--------
    rs1899003811,2
    --112277559(+) CAAAAA/GACTCA 1 -- ds50010--------
    rs31776471,2
    C,F,A,H--112277576(-) TGACCG/ATTTAC 1 -- nc-transcript-variant26Minor allele frequency- A:0.25NS EA NA WA CSA 2775
    rs605796961,2
    C--112277592(+) GTTTA-/TTTTAT 1 -- nc-transcript-variant0--------
    rs1823785141,2
    --112277617(+) ACTGAA/GTGGAT 1 -- nc-transcript-variant0--------
    rs1870534721,2
    --112277654(+) CTCCAC/TTTAGG 1 -- nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for MAPKAPK5-AS1 (112277571 - 112280706 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MAPKAPK5-AS1: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MAPKAPK5-AS1
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPKAPK5-AS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPKAPK5-AS1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MAPKAPK5-AS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51275 HGNC: 24091 AceView: FLJ39616 Ensembl:ENSG00000234608 euGenes: HUgn51275
    ECgene: MAPKAPK5-AS1 H-InvDB: MAPKAPK5-AS1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAPKAPK5-AS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAPKAPK5-AS1 gene:
    Search GeneIP for patents involving MAPKAPK5-AS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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      Search antibodies-online for antibodies for MAPKAPK5-AS1
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