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MAPKAPK5 Gene

protein-coding   GIFtS: 63
GCID: GC12P112282

Mitogen-Activated Protein Kinase-Activated Protein Kinase...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase-Activated Protein Kinase 51 2     MAPK-Activated Protein Kinase 52 3
PRAK2 3 5     MAPKAP Kinase 52 3
MAPKAP-K52 3     P38-Regulated/Activated Protein Kinase2 3
MAPKAPK-52 3     EC 2.7.11.13 8
MK-52 3     MAP Kinase-Activated Protein Kinase 52
MK52 3     EC 2.7.118

External Ids:    HGNC: 68891   Entrez Gene: 85502   Ensembl: ENSG000000890227   OMIM: 6067235   UniProtKB: Q8IW413   

Export aliases for MAPKAPK5 gene to outside databases

Previous GC identifers: GC12P111177 GC12P111802 GC12P112062 GC12P110692 GC12P110691 GC12P110742 GC12P109293


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPKAPK5 Gene:
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In
response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation
by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the
nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat
shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this
gene encoding distinct isoforms have been reported. (provided by RefSeq, Nov 2012)

GeneCards Summary for MAPKAPK5 Gene:
MAPKAPK5 (mitogen-activated protein kinase-activated protein kinase 5) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and MAP kinase kinase activity. An important paralog of this gene is RPS6KA6.

UniProtKB/Swiss-Prot: MAPK5_HUMAN, Q8IW41
Function: Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional
regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor
suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional
regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear
localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that
bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling
by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with
ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear,
but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6
or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of
MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in
response to PKA/PRKACA stimulation, inducing F-actin rearrangement

Gene Wiki entry for MAPKAPK5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPKAPK5 gene promoter:
         p53   AP-2beta   AP-2gamma   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAPKAPK5 promoter sequence
   Search Chromatin IP Primers for MAPKAPK5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPKAPK5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.13   Ensembl cytogenetic band:  12q24.12   HGNC cytogenetic band: 12q24.13

MAPKAPK5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPKAPK5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P112282:  view genomic region     (about GC identifiers)

Start:
112,279,782 bp from pter      End:
112,334,343 bp from pter
Size:
54,562 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MAPK5_HUMAN, Q8IW41 (See protein sequence)
Recommended Name: MAP kinase-activated protein kinase 5  
Size: 473 amino acids; 54220 Da
Subunit: Interacts with ERK3/MAPK6 and ERK4/MAPK4 (via FRIEDE motif); the interaction is direct (By similarity).
Interacts with YWHAE; the interaction prevents phosphorylation of HSP27/HSPB1 leading to disrupt F-actin
polymerization. Interacts with SQSTM1
Caution: The role of p38 MAPK kinases is unclear in phosphorylation and activation of MAPKAPK5. According to some
reports, it interacts and is phosphorylated by p38-alpha/MAPK14 and p38-beta/MAPK11 (PubMed:9628874 and
PubMed:12808055). According to other reports, it is not activated by p38-alpha/MAPK14 and p38-beta/MAPK11. An
explanation for these discrepancies, might be that the interaction with p38 MAPK kinases is weak and occurs only
under specific conditions
Secondary accessions: B3KVA5 O60491 Q86X46 Q9BVX9 Q9UG86
Alternative splicing: 2 isoforms:  Q8IW41-1   Q8IW41-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAPKAPK5: NX_Q8IW41

Explore proteomics data for MAPKAPK5 at MOPED

Post-translational modifications: 

  • Phosphorylated on Thr-182 ERK3/MAPK6 or ERK4/MAPK4; which is the regulatory phosphorylation site and is located on
    the T-loop/loop 12, leading to activation. Phosphorylation at Thr-182 by p38-alpha/MAPK14, p38-beta/MAPK11 is
    subject to debate. Phosphorylated at Ser-115 by PKA/PRKACA, leading to localization to the cytoplasm.
    Autophosphorylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for MAPKAPK5 (Q8IW41)
     TPYYVAP  LKPENLL  RDLKPEN  DLWSLGV 


    See MAPKAPK5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003659.2  NP_620777.1  

    ENSEMBL proteins: 
     ENSP00000449667   ENSP00000473541   ENSP00000448408   ENSP00000449381   ENSP00000473467  
    Reactome Protein details: Q8IW41

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase-activated protein kinase 5
    MAPKAPK subfamily

    5 InterPro protein domains:
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom
     IPR027442 MAPKAPK_C

    Graphical View of Domain Structure for InterPro Entry Q8IW41

    ProtoNet protein and cluster: Q8IW41

    UniProtKB/Swiss-Prot: MAPK5_HUMAN, Q8IW41
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with MAPKAPK5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAPK5_HUMAN, Q8IW41
    Function: Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional
    regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor
    suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional
    regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear
    localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that
    bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling
    by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with
    ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear,
    but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6
    or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of
    MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in
    response to PKA/PRKACA stimulation, inducing F-actin rearrangement
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated following phosphorylation at Thr-182 by p38-alpha/MAPK14, p38-beta/MAPK11,
    ERK2/MAPK1, ERK3/MAPK6, and ERK4/MAPK4. Activated by stress-related extracellular stimuli; such as H(2)O(2),
    arsenite, anisomycin TNF alpha and also PMA and the calcium ionophore A23187; but to a lesser extent. In vitro,
    activated by SQSTM1. Inhibited by diterpenoid alkaloid noroxoaconitine
    Induction: Directly regulated by MYC: expression is activated by MYC, suggesting the existence of a feedback
    regulatory loop

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IDA17254968
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA17254968
    GO:0004708MAP kinase kinase activity TAS9628874
    GO:0004713protein tyrosine kinase activity ----
         
    Find genes that share ontologies with MAPKAPK5           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for MAPKAPK5:
     Decreased substrate adherent c  Decreased telomerase activity  Increased cell death HMECs cel  Synthetic lethal with Ras 
     Synthetic lethal with c-Myc af 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mapkapk5):
     cellular  integument  mortality/aging  normal  tumorigenesis 

    Find genes that share phenotypes with MAPKAPK5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MAPKAPK5: Mapkapk5tm1Mgl Mapkapk5tm1Pqs

       genOway: Develop your customized and physiologically relevant rodent model for MAPKAPK5

    miRNA
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    miRTarBase miRNAs that target MAPKAPK5:
    hsa-mir-615-3p (MIRT039763)

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    2 qRT-PCR Assays for microRNAs that regulate MAPKAPK5:
    hsa-miR-186 hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidMAPKAPK5 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAPK5_HUMAN, Q8IW41: Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following phosphorylation and
    activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein
    kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also
    induces nuclear export
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016020membrane ----

    Find genes that share ontologies with MAPKAPK5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPKAPK5 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    3Akt Signaling
    p38 Signaling0.60
    4TGF-Beta Pathway
    MAPK Family Pathway0.60
    5Immune response Fc epsilon RI pathway
    VEGF - VEGF R2 Signaling Pathways0.35


    Find genes that share SuperPaths with MAPKAPK5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for MAPKAPK5
        VEGF - VEGF R2 Signaling Pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAPKAPK5
        p38 Signaling
    MAPK Family Pathway

    1 Cell Signaling Technology (CST) Pathway for MAPKAPK5
        MAP Kinase Signaling

    3 BioSystems Pathways for MAPKAPK5
        MAPK signaling pathway
    p38 MAPK Signaling Pathway
    Signaling mediated by p38-alpha and p38-beta


    1 Reactome Pathway for MAPKAPK5
        Oxidative Stress Induced Senescence


    1 Kegg Pathway  (Kegg details for MAPKAPK5):
        MAPK signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAPKAPK5
    Interactions:

        GeneGlobe Interaction Network for MAPKAPK5

    Selected Interacting proteins for MAPKAPK5 (Q8IW411, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166591, 2, 3EBI-1201460,EBI-1384105 MINT-8261384 I2D: score=5 
    TP53P046371, 3EBI-1201460,EBI-366083 I2D: score=4 
    HSPB1P047921, 3EBI-1201460,EBI-352682 I2D: score=3 
    RPL13P263732, 3MINT-8262797 I2D: score=2 
    TAB1Q157502, 3MINT-8260185 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade TAS9628874
    GO:0000187activation of MAPK activity TAS9628874
    GO:0006417regulation of translation IDA--
    GO:0006468protein phosphorylation ----
    GO:0007165signal transduction TAS9628874

    Find genes that share ontologies with MAPKAPK5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MAPKAPK5 (MAPK5)

    3 HMDB Compounds for MAPKAPK5    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAPKAPK5 gene (2 alternative transcripts): 
    NM_003668.3  NM_139078.2  

    Unigene Cluster for MAPKAPK5:

    Mitogen-activated protein kinase-activated protein kinase 5
    Hs.413901  [show with all ESTs]
    Unigene Representative Sequence: AK122767
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000550735 ENST00000547305 ENST00000553053 ENST00000546394 ENST00000551404
    ENST00000549875 ENST00000602983 ENST00000552111 ENST00000547067 ENST00000547915

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    Additional mRNA sequence: 

    AF462689.1 AK122767.1 AL110301.1 BC000833.1 BC041049.1 BC047284.1 

    17 DOTS entries:

    DT.215279  DT.101981945  DT.100787424  DT.75103422  DT.91658989  DT.100726735  DT.100787415  DT.100027769 
    DT.121204599  DT.95171419  DT.95274200  DT.95329771  DT.100787416  DT.101960945  DT.86857809  DT.92046948 
    DT.95171417 

    Selected AceView cDNA sequences (see all 180):

    AA236747 AL538648 BC041049 BU623945 BM840868 BM786599 AW299569 BM737767 
    BM929316 BM981265 BQ002656 AI381300 BQ189132 BQ023791 BM665331 BX101151 
    AI459236 AA626202 CA950646 BC047284 BM929434 NM_003668 AA677909 CR618097 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAPK5 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17
    SP1:                                                                    -                                                                                 
    SP2:                                                                    -                                                                                 
    SP3:                                                                    -                                                                                 
    SP4:                                                                                                                                                      
    SP5:                                                                    -                                                                                 


    ECgene alternative splicing isoforms for MAPKAPK5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAPKAPK5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAATGGAGC
    MAPKAPK5 Expression
    About this image


    MAPKAPK5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    MAPKAPK5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPKAPK5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.413901

    UniProtKB/Swiss-Prot: MAPK5_HUMAN, Q8IW41
    Tissue specificity: Expressed ubiquitously

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAPKAPK5 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapkapk51 , 5 MAP kinase-activated protein kinase 51, 5 90.7(n)1
    97.25(a)1
      5 (61.84 cM)5
    171651  NM_010765.21  NP_034895.11 
     1215186135 
    chicken
    (Gallus gallus)
    Aves MAPKAPK51 mitogen-activated protein kinase-activated protein more 85.88(n)
    96.34(a)
      373929  NM_001199807.1  NP_001186736.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAPKAPK56
    mitogen-activated protein kinase-activated protein...
    94(a)
    1 ↔ 1
    GL343282.1(37793-62633)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.178452 Transcribed sequence with strong similarity to protein more 81.06(n)    BX750226.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK026380.12   -- 78.86(n)    CK026380.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RCK16
    RCK26
    Protein kinase involved in the response to oxidati...
    Protein kinase involved in the response to oxidati...
    22(a)
    18(a)
    many ↔ many
    many ↔ many
    VII(207033-208571) YGL158W
    XII(634252-636084) YLR248W


    ENSEMBL Gene Tree for MAPKAPK5 (if available)
    TreeFam Gene Tree for MAPKAPK5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAPKAPK5 gene
    RPS6KA62  MAPKAPK32  RPS6KA12  RPS6KA52  MAPKAPK22  RPS6KA42  MKNK12  MKNK22  
    RPS6KA32  RPS6KA22  
    14 SIMAP similar genes for MAPKAPK5 using alignment to 4 protein entries:     MAPK5_HUMAN (see all proteins):
    MAPKAPK2    MKNK2    MAPKAPK3    DAPK3    PRKD1    TRIB1
    PNCK    CAMK1    MKNK1    AKT2    AURKC    RPS6KA5
    CAMK1D    RPS6KA1

    Find genes that share paralogs with MAPKAPK5           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MAPKAPK5
    PGOHUM00000238913


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAPKAPK5 (see all 896)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1402796281,2
    --112282765(+) GCCTTC/GTAGGC 2 -- int10--------
    rs1838609711,2
    --112282772(+) AGGCCA/GTCGTA 2 -- int10--------
    rs1879298981,2
    --112282774(+) GCCATC/TGTAAG 2 -- int10--------
    rs577868271,2
    C,F--112282838(+) AAGAGA/GGACAT 2 -- int15Minor allele frequency- G:0.10NA WA CSA 243
    rs1502263401,2
    C--112282914(+) GGTAGA/GCTCAG 2 -- int10--------
    rs564116371,2
    C--112282998(+) ATCTCA/GGCTCA 2 -- int10--------
    rs122304101,2
    C--112283040(+) tcttgG/Tgcctt 2 -- int12Minor allele frequency- T:0.46WA EA 122
    rs122288441,2
    C--112283050(+) tggccC/Gtccga 2 -- int13Minor allele frequency- G:0.30WA EA 240
    rs1419893271,2
    --112283089(+) ACGCCC/TGGCTA 2 -- int10--------
    rs1463044321,2
    --112283282(+) TAGCCA/GTGTGT 2 -- int10--------

    HapMap Linkage Disequilibrium report for MAPKAPK5 (112279782 - 112334343 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MAPKAPK5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1010936CNV Deletion20482838
    esv2746359CNV Deletion23290073
    esv2665280CNV Deletion23128226
    esv6864CNV Loss19470904
    nsv515716CNV Gain19592680
    dgv1492n71CNV Gain21882294
    nsv470317CNV Gain18288195
    nsv455715CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606723    OMIM disorders: --


    Find genes that share disorders with MAPKAPK5           About GenesLikeMe


    Export disorders for MAPKAPK5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPKAPK5 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with MAPKAPK5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PRAK, a novel protein kinase regulated by the p38 MAP kinase. (PubMed id 9628874)1, 2, 3, 9 New L.... Han J. (EMBO J. 1998)
    2. Regulation of PRAK subcellular location by p38 MAP kinases. (PubMed id 12808055)1, 2, 9 New L.... Han J. (Mol. Biol. Cell 2003)
    3. PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5. (PubMed id 19166925)1, 2 Kostenko S.... Moens U. (Cell. Signal. 2009)
    4. PRAK is essential for ras-induced senescence and tumor suppression. (PubMed id 17254968)1, 2 Sun P.... Han J. (Cell 2007)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. p62 functions as a p38 MAP kinase regulator. (PubMed id 10708586)1, 2 Sudo T.... Osada H. (Biochem. Biophys. Res. Commun. 2000)
    8. Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. (PubMed id 18720373)1, 9 DAclAcris P....Meloche S. (J. Cell. Physiol. 2008)
    9. A posttranslational modification cascade involving p38, Tip60, and PRAK mediates oncogene-induced senescence. (PubMed id 23685072)1 Zheng H....Sun P. (Mol. Cell 2013)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8550 HGNC: 6889 AceView: MAPKAPK5 Ensembl:ENSG00000089022 euGenes: HUgn8550
    ECgene: MAPKAPK5 Kegg: 8550 H-InvDB: MAPKAPK5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAPKAPK5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPKAPK5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAPKAPK5 gene:
    Search GeneIP for patents involving MAPKAPK5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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