MAPKAPK5 Gene
protein-coding GIFtS: 59
GCID: GC12P112282
|
|
mitogen-activated protein kinase-activated protein kinase...
| |
Aliases
for MAPKAPK5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitogen-Activated Protein Kinase-Activated Protein Kinase 51 2 | | MAPK-Activated Protein Kinase 52 3 | | PRAK1 2 3 5 | | MAPKAP Kinase 52 3 | | MAPKAP-K52 3 | | P38-Regulated/Activated Protein Kinase2 3 | | MAPKAPK-52 3 | | EC 2.7.11.13 8 | | MK-52 3 | | MAP Kinase-Activated Protein Kinase 52 | | MK52 3 | | EC 2.7.118 |
Export aliases for MAPKAPK5 gene to outside databasesPrevious GC identifers: GC12P111177 GC12P111802 GC12P112062 GC12P110692 GC12P110691 GC12P110742 GC12P109293 |
Summaries
for MAPKAPK5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAPKAPK5:
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response tocellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinasesincluding MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus buttranslocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinctisoforms have been reported. (provided by RefSeq, Nov 2012)
UniProtKB/Swiss-Prot: MAPK5_HUMAN, Q8IW41Function: Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptionalregulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressorby mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYCby mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3,enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYCtranscript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylationand inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: theprecise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complexset of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (orERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turnphosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACAstimulation, inducing F-actin rearrangement
Gene Wiki entry for MAPKAPK5
|
Genomic Views
for MAPKAPK5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009775.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAPKAPK5 gene promoter:
p53 AP-2beta AP-2gamma
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAPKAPK5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPKAPK5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.13 Ensembl cytogenetic band: 12q24.12 HGNC cytogenetic band: 12q24.13MAPKAPK5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P112282: view genomic region
(about GC identifiers)
Start:
|
112,279,782 bp from pter |
End:
|
112,334,343 bp from pter |
Size:
|
54,562 bases |
Orientation:
|
plus strand |
|
Proteins
for MAPKAPK5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAPK5_HUMAN, Q8IW41 (See
protein sequence)Recommended Name: MAP kinase-activated protein kinase 5 Size: 473 amino acids; 54220 Da
Subunit: Interacts with ERK3/MAPK6 and ERK4/MAPK4 (via FRIEDE motif); the interaction is direct (By similarity).Interacts with YWHAE; the interaction prevents phosphorylation of HSP27/HSPB1 leading to disrupt F-actinpolymerization. Interacts with SQSTM1
Subcellular location: Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following phosphorylation and activation.Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity,followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export
Caution: The role of p38 MAPK kinases is unclear in phosphorylation and activation of MAPKAPK5. According to somereports, it interacts and is phosphorylated by p38-alpha/MAPK14 and p38-beta/MAPK11 (PubMed:9628874 andPubMed:12808055). According to other reports, it is not activated by p38-alpha/MAPK14 and p38-beta/MAPK11. Anexplanation for these discrepancies, might be that the interaction with p38 MAPK kinases is weak and occurs only underspecific conditions
Secondary accessions: B3KVA5 O60491 Q86X46 Q9BVX9 Q9UG86Alternative splicing: 2 isoforms: Q8IW41-1 Q8IW41-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MAPKAPK5: NX_Q8IW41
Post-translational modifications:
Phosphorylated on Thr-182 ERK3/MAPK6 or ERK4/MAPK4; which is the regulatory phosphorylation site and is located on theT-loop/loop 12, leading to activation. Phosphorylation at Thr-182 by p38-alpha/MAPK14, p38-beta/MAPK11 is subject todebate. Phosphorylated at Ser-115 by PKA/PRKACA, leading to localization to the cytoplasm. Autophosphorylated (Bysimilarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IW41
4 DME Specific Peptides for MAPKAPK5 (Q8IW41)
MAPKAPK5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_003659.2 NP_620777.1
ENSEMBL proteins: ENSP00000449667 ENSP00000448408 ENSP00000449594 ENSP00000449381 ENSP00000448283 ENSP00000448727 ENSP00000202788 ENSP00000409640
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MAPKAPK5 for ontologies About GeneDecksing
MAPKAPK5 Antibody Products:
Assay Products for MAPKAPK5: |
Protein
Domains /
Families
for MAPKAPK5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAPKAPK5 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IW41ProtoNet protein and cluster: Q8IW41 UniProtKB/Swiss-Prot: MAPK5_HUMAN, Q8IW41Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase familySimilarity: Contains 1 protein kinase domain |
Function
for MAPKAPK5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MAPK5_HUMAN, Q8IW41Function: Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptionalregulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressorby mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYCby mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3,enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYCtranscript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylationand inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: theprecise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complexset of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (orERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turnphosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACAstimulation, inducing F-actin rearrangementCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated following phosphorylation at Thr-182 by p38-alpha/MAPK14, p38-beta/MAPK11, ERK2/MAPK1,ERK3/MAPK6, and ERK4/MAPK4. Activated by stress-related extracellular stimuli; such as H(2)O(2), arsenite, anisomycinTNF alpha and also PMA and the calcium ionophore A23187; but to a lesser extent. In vitro, activated by SQSTM1.Inhibited by diterpenoid alkaloid noroxoaconitineInduction: Directly regulated by MYC: expression is activated by MYC, suggesting the existence of a feedback regulatoryloopEnzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAPK5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAPK5 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MAPKAPK5 (NM_003668) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAPKAPK5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPKAPK5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPKAPK5 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
MAPKAPK5 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for MAPKAPK5:
Animal Models:
Mouse knock-outs for MAPKAPK5: Mapkapk5tm1Mgl Mapkapk5tm1Pqs
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Mapkapk5):
MAPKAPK5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MAPKAPK5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | MAPK signaling pathway | | | 2 | MAP Kinase Signaling | | | 3 | p38 MAPK Signaling Pathway | | | 4 | Signaling mediated by p38-alpha and p38-beta | | | 5 | Akt Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPKAPK5
1 
Cell Signaling Technology (CST) Pathway for MAPKAPK5
3  BioSystems Pathways for MAPKAPK5
1 
Kegg Pathway (Kegg details for MAPKAPK5):
MAPKAPK5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPKAPK5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/33 Interacting proteins for MAPKAPK5 (Q8IW411, 2, 3 ENSP000002027884) via UniProtKB, MINT, STRING, and/or I2D (see all 33)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| TP53 | P046371, 3, ENSP000002693054 | EBI-1201460,EBI-366083 I2D:
score=4 STRING: ENSP00000269305 | | HSPB1 | P047921, 3, ENSP000002485534 | EBI-1201460,EBI-352682 I2D:
score=3 STRING: ENSP00000248553 | | TAB1 | Q157502, 3, ENSP000002161604 | MINT-8260185 I2D:
score=2 STRING: ENSP00000216160 | | ZNF282 | Q9UDV72, 3, ENSP000002620854 | MINT-8262808 I2D:
score=2 STRING: ENSP00000262085 | | RPL13 | P263732, 3 | MINT-8262797 I2D:
score=2 |
About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
MAPKAPK5 for ontologies About GeneDecksing
|
Drugs & Compounds
for MAPKAPK5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAPKAPK5
3 HMDB Compounds for MAPKAPK5 About this table
Search CenterWatch for drugs/clinical trials and news about MAPKAPK5 / MAPK5
|
Transcripts
for MAPKAPK5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAPKAPK5 gene (2 alternative transcripts): NM_003668.3 NM_139078.2 Unigene Cluster for MAPKAPK5: Mitogen-activated protein kinase-activated protein kinase 5 Hs.413901 [show with all ESTs]Unigene Representative Sequence: AK12276711 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000550735 ENST00000547305 ENST00000553053 ENST00000546394 ENST00000551404
ENST00000549875 ENST00000552111 ENST00000547067 ENST00000547915 ENST00000202788(uc001tta.3)
ENST00000428907(uc001tsz.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAPK5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAPK5 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MAPKAPK5 (NM_003668) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAPKAPK5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPKAPK5 |
Additional cDNA sequence: AK122767.1 AL110301.1 BC000833.1 BC041049.1 BC047284.1 16 DOTS entries: DT.215279 DT.101981945 DT.100787424 DT.75103422 DT.91658989 DT.100726735 DT.100787415 DT.100027769 DT.121204599 DT.95171419 DT.95274200 DT.100787416 DT.101960945 DT.86857809 DT.92046948 DT.95171417 24/180 AceView cDNA sequences (see all 180): BI962681 AI381300 CA950406 AL556217 BM840868 CA394127 AW299569 BG413516 BX101151 AL538648 BC041049 AI799703 BE250784 AA626202 BM929316 AI560943 CR618097 BE784522 BM982274 CA950646 AA746505 BM786599 AK122767 NM_139078
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAPK5 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | ^ | 16 | ^ | 17 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MAPKAPK5
|
Expression
for MAPKAPK5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAPKAPK5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAATGGAGC
About this image
See MAPKAPK5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAPKAPK5
SOURCE GeneReport for Unigene cluster: Hs.413901
UniProtKB/Swiss-Prot: MAPK5_HUMAN, Q8IW41Tissue specificity: Expressed ubiquitously
SABiosciences Custom PCR Arrays for MAPKAPK5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAPKAPK5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAPKAPK5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPKAPK5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPKAPK5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPKAPK5 |
Orthologs
for MAPKAPK5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MAPKAPK5 gene from 4/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MAPKAPK51 |
mitogen-activated protein kinase-activated protein more |
85.88(n)
96.34(a) |
|
373929 NM_001199807.1 NP_001186736.1 |
lizard
(Anolis carolinensis) |
Reptilia |
MAPKAPK56 |
-- |
94(a) |
1 ↔ 1 |
GL343282.1(45377-62633) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.178452 |
Transcribed sequence with strong similarity to protein more |
81.06(n) |
|
BX750226.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
CK026380.12 |
-- |
78.86(n) |
|
CK026380.1 |
ENSEMBL Gene Tree for MAPKAPK5 (if available)
TreeFam Gene Tree for MAPKAPK5 (if available) |
Paralogs
for MAPKAPK5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAPKAPK5 gene
- MAPKAPK32 MAPKAPK22 MKNK12 MKNK22
18/42 SIMAP similar genes for MAPKAPK5 using alignment to 7 protein entries: MAPK5_HUMAN (see all proteins)
(see all similar genes):CHEK2 PRKD2 DCLK2 MGC45428 MAPKAPK2 CAMK2G
CAMK4 MAPKAPK3 CAMK2B CAMKV MKNK2 PRKD1
CAMK2A CASK DAPK2 STK33 CAMK2D DCLK3
MAPKAPK5 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MAPKAPK5
PGOHUM00000238913
|
Genomic Variants
for MAPKAPK5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAPKAPK5 (112279782 - 112334343 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MAPKAPK5
1 CNV: 61278 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAPKAPK5 |
|
Disorders
/ Diseases
for MAPKAPK5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAPKAPK5 for disorders About GeneDecksing
OMIM gene information: 606723
OMIM disorders: --
8  diseases for MAPKAPK5: About MalaCardsal amyloidosis yellow fever amyloidosis prostate cancer
pneumonia prostatitis malaria alcoholism
Export disorders for MAPKAPK5 gene to outside databases
|
Publications
for MAPKAPK5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAPKAPK5 gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with MAPKAPK5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- PRAK, a novel protein kinase regulated by the p38 MAP kinase. (PubMed id 9628874)1, 2, 3, 9 New L.... Han J. (1998)
- Regulation of PRAK subcellular location by p38 MAP kinases. (PubMed id 12808055)1, 2, 9 New L....Han J. (2003)
- PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5. (PubMed id 19166925)1, 2 Kostenko S....Moens U. (2009)
- PRAK is essential for ras-induced senescence and tumor suppression. (PubMed id 17254968)1, 2 Sun P....Han J. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- p62 functions as a p38 MAP kinase regulator. (PubMed id 10708586)1, 2 Sudo T.... Osada H. (2000)
- Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. (PubMed id 18720373)1, 9 Deleris P....Meloche S. (2008)
- IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling. (PubMed id 22279049)1 Stohr N....Huttelmaier S. (2012)
- Cross-talk between protein kinase A and the MAPK-acti vated protein kinases RSK1 and MK5. (PubMed id 20849292)1 Kostenko S....Moens U. (2011)
|
External Searches for MAPKAPK5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAPKAPK5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAPKAPK5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAPKAPK5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MAPKAPK5 gene:
Search GeneIP for patents involving MAPKAPK5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAPKAPK5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for MAPKAPK5 | | OriGene shRNA RFP for MAPKAPK5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPKAPK5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAPKAPK5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAPKAPK5 | | OriGene 3'-UTR Clone for MAPKAPK5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAPK5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAPK5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MAPKAPK5 | | OriGene Custom Protein Services for MAPKAPK5 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAPKAPK5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAPKAPK5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPKAPK5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPKAPK5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPKAPK5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPKAPK5 |
| |
 |  |  |  | |
| | | |  |  |  |  | | | | |
 |
 |
 |
 | | | MAPKAPK5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPKAPK5 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPKAPK5 |
|
|
|
|
